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ONTOLOGY REPORT - ANNOTATIONS

Term:complement activation, lectin pathway
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Accession:GO:0001867 term browser browse the term
Definition:Any process involved in the activation of any of the steps of the lectin pathway of the complement cascade which allows for the direct killing of microbes and the regulation of other immune processes.
Comment:Note that proteins such as mannose-binding lectin (MBL) and certain serum ficolins can activate the lectin complement pathway.
Synonyms:exact_synonym: complement cascade, lectin pathway
 xref: Reactome:R-HSA-166662 "Lectin pathway of complement activation"


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complement activation, lectin pathway term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Colec10 collectin sub-family member 10 involved_in IEA
ISO 		Ensembl
GO_Central		 GO_REF:0000107 GO_REF:0000119 NCBI chr15:54,274,170...54,329,755
Ensembl chr15:54,274,170...54,329,754 		JBrowse link
G Colec11 collectin sub-family member 11 involved_in ISS
ISO 		UniProt
GO_Central		 GO_REF:0000024 GO_REF:0000119 NCBI chr12:28,644,171...28,673,458
Ensembl chr12:28,644,172...28,673,376 		JBrowse link
G Fcna ficolin A involved_in IBA GO_Central GO_REF:0000033 NCBI chr 2:25,514,677...25,525,448
Ensembl chr 2:25,514,678...25,518,042 		JBrowse link
G Fcnb ficolin B involved_in IEA
IBA 		Ensembl
GO_Central		 GO_REF:0000033 GO_REF:0000107 NCBI chr 2:27,966,491...27,974,921
Ensembl chr 2:27,966,390...27,974,897 		JBrowse link
G Krt1 keratin 1 involved_in IEA
ISO 		Ensembl
GO_Central		 GO_REF:0000107 GO_REF:0000119 NCBI chr15:101,753,861...101,759,221
Ensembl chr15:101,753,861...101,759,229 		JBrowse link
G Masp1 MBL associated serine protease 1 involved_in IBA
IMP
ISO 		(PMID:18424734) GO_Central
UniProt		 PMID:18424734 GO_REF:0000033 GO_REF:0000119 NCBI chr16:23,261,778...23,340,127
Ensembl chr16:23,268,167...23,339,565 		JBrowse link
G Masp2 MBL associated serine protease 2 involved_in IBA
ISO
IEA 		GO_Central
Ensembl		 GO_REF:0000033 GO_REF:0000107 GO_REF:0000119 NCBI chr 4:148,679,079...148,699,939
Ensembl chr 4:148,687,011...148,699,956 		JBrowse link
G Mbl1 mannose-binding lectin (protein A) 1 involved_in
acts_upstream_of_or_within 		ISO
IDA
IGI 		(PMID:15148336) RGD
GO_Central
MGI		 PMID:15148336 PMID:16272342 GO_REF:0000096 RGD:1582134 NCBI chr14:40,873,413...40,885,861
Ensembl chr14:40,873,415...40,881,558 		JBrowse link
G Mbl2 mannose-binding lectin (protein C) 2 acts_upstream_of_or_within
involved_in 		IMP
ISO
IDA
IGI 		(PMID:15148336) MGI
GO_Central		 PMID:15148336 GO_REF:0000008 GO_REF:0000119 NCBI chr19:30,210,306...30,217,087
Ensembl chr19:30,210,342...30,217,087 		JBrowse link
negative regulation of complement activation, lectin pathway term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G A2m alpha-2-macroglobulin involved_in ISO
IEA 		GO_Central
Ensembl		 GO_REF:0000107 GO_REF:0000119 NCBI chr 6:121,612,920...121,656,197
Ensembl chr 6:121,612,335...121,656,186 		JBrowse link
G Serping1 serine (or cysteine) peptidase inhibitor, clade G, member 1 involved_in ISO
ISS 		GO_Central
UniProt		 GO_REF:0000024 GO_REF:0000119 NCBI chr 2:84,595,704...84,605,748
Ensembl chr 2:84,595,731...84,605,788 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 28626
    immune system process 3186
      immune response 2238
        innate immune response 1163
          complement activation, lectin pathway 11
            negative regulation of complement activation, lectin pathway 2
            positive regulation of complement activation, lectin pathway 0
            regulation of complement activation, lectin pathway + 2
Path 2
Term Annotations click to browse term
  biological_process 28626
    biological regulation 13468
      regulation of biological process 13028
        positive regulation of biological process 6990
          positive regulation of response to stimulus 2700
            positive regulation of immune response 876
              activation of immune response 639
                complement activation 67
                  complement activation, lectin pathway 11
                    negative regulation of complement activation, lectin pathway 2
                    positive regulation of complement activation, lectin pathway 0
                    regulation of complement activation, lectin pathway + 2
paths to the root