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ONTOLOGY REPORT - ANNOTATIONS

Term:complement activation, lectin pathway
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Accession:GO:0001867 term browser browse the term
Definition:Any process involved in the activation of any of the steps of the lectin pathway of the complement cascade which allows for the direct killing of microbes and the regulation of other immune processes.
Comment:Note that proteins such as mannose-binding lectin (MBL) and certain serum ficolins can activate the lectin complement pathway.
Synonyms:exact_synonym: complement cascade, lectin pathway
 xref: Reactome:R-HSA-166662 "Lectin pathway of complement activation"


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complement activation, lectin pathway term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G COLEC10 collectin subfamily member 10 involved_in IEA Ensembl GO_REF:0000107 NCBI chr13:18,291,168...18,331,918
Ensembl chr13:18,291,051...18,330,617 		JBrowse link
G COLEC11 collectin subfamily member 11 involved_in IEA Ensembl GO_REF:0000107 NCBI chr17:2,147,679...2,180,096
Ensembl chr17:2,147,882...2,180,098 		JBrowse link
G FCN2 ficolin 2 involved_in IBA GO_Central GO_REF:0000033 NCBI chr 9:50,868,942...50,876,001
Ensembl chr 9:50,868,973...50,875,792 		JBrowse link
G FCN3 ficolin 3 involved_in ISO (PMID:11907111) UniProt PMID:11907111
G KRT1 keratin 1 involved_in ISO (PMID:11549596) UniProt PMID:11549596 NCBI chr27:2,422,150...2,427,160 JBrowse link
G MASP1 MBL associated serine protease 1 involved_in IBA
IEA 		GO_Central
Ensembl		 GO_REF:0000033 GO_REF:0000107 NCBI chr34:19,689,426...19,750,669
Ensembl chr34:19,691,630...19,750,587 		JBrowse link
G MASP2 MBL associated serine protease 2 involved_in IEA
IBA 		Ensembl
GO_Central		 GO_REF:0000033 GO_REF:0000107 NCBI chr 2:84,976,366...84,987,376
Ensembl chr 2:84,976,456...84,989,797 		JBrowse link
G MBL1 mannose binding lectin 1 acts_upstream_of_or_within
involved_in 		ISO (PMID:15148336)
(PMID:11549596)
(PMID:22691502), (PMID:35102342) 		MGI
UniProt
ComplexPortal		 PMID:11549596 PMID:15148336 PMID:22691502 PMID:35102342 NCBI chr 4:29,419,886...29,424,377 JBrowse link
negative regulation of complement activation, lectin pathway term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G A2M alpha-2-macroglobulin involved_in IEA Ensembl GO_REF:0000107 NCBI chr27:36,654,328...36,695,775 JBrowse link
G SERPING1 serpin family G member 1 involved_in IEA Ensembl GO_REF:0000107 NCBI chr18:38,570,354...38,580,751
Ensembl chr18:38,570,607...38,581,665 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 22130
    immune system process 2648
      immune response 1728
        innate immune response 934
          complement activation, lectin pathway 10
            negative regulation of complement activation, lectin pathway 2
            positive regulation of complement activation, lectin pathway 0
            regulation of complement activation, lectin pathway + 2
Path 2
Term Annotations click to browse term
  biological_process 22130
    biological regulation 12559
      regulation of biological process 12177
        positive regulation of biological process 6621
          positive regulation of response to stimulus 2499
            positive regulation of immune response 755
              activation of immune response 556
                complement activation 51
                  complement activation, lectin pathway 10
                    negative regulation of complement activation, lectin pathway 2
                    positive regulation of complement activation, lectin pathway 0
                    regulation of complement activation, lectin pathway + 2
paths to the root