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ONTOLOGY REPORT - ANNOTATIONS

Term:complement activation, lectin pathway
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Accession:GO:0001867 term browser browse the term
Definition:Any process involved in the activation of any of the steps of the lectin pathway of the complement cascade which allows for the direct killing of microbes and the regulation of other immune processes.
Comment:Note that proteins such as mannose-binding lectin (MBL) and certain serum ficolins can activate the lectin complement pathway.
Synonyms:exact_synonym: complement cascade, lectin pathway
 xref: Reactome:R-HSA-166662 "Lectin pathway of complement activation"


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complement activation, lectin pathway term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G COLEC10 collectin subfamily member 10 involved_in IEA Ensembl GO_REF:0000107 NCBI chr 8:115,758,592...115,798,548
Ensembl chr 8:118,277,484...118,317,271 		JBrowse link
G COLEC11 collectin subfamily member 11 involved_in IEA Ensembl GO_REF:0000107 NCBI chr2A:3,610,679...3,659,739
Ensembl chr2A:3,529,358...3,579,517 		JBrowse link
G FCN3 ficolin 3 involved_in IEA Ensembl
TreeGrafter		 GO_REF:0000107 GO_REF:0000118 NCBI chr 1:26,620,373...26,636,424
Ensembl chr 1:27,676,866...27,683,861 		JBrowse link
G LOC100970659 keratin, type II cytoskeletal 1 involved_in IEA Ensembl GO_REF:0000107 NCBI chr12:36,083,858...36,089,521
Ensembl chr12:36,861,585...36,866,725 		JBrowse link
G LOC100994627 ficolin-2 involved_in IEA Ensembl
TreeGrafter		 GO_REF:0000107 GO_REF:0000118 NCBI chr 9:105,995,807...106,020,389
Ensembl chr 9:134,997,038...135,018,992 		JBrowse link
G LOC100994951 ficolin-1 involved_in IEA TreeGrafter GO_REF:0000118 NCBI chr 9:106,039,315...106,047,648
Ensembl chr 9:135,040,310...135,049,111 		JBrowse link
G MASP1 MBL associated serine protease 1 involved_in IEA TreeGrafter
Ensembl		 GO_REF:0000107 GO_REF:0000118 NCBI chr 3:184,241,611...184,317,272
Ensembl chr 3:192,707,784...192,782,196 		JBrowse link
G MASP2 MBL associated serine protease 2 involved_in IEA Ensembl
TreeGrafter		 GO_REF:0000107 GO_REF:0000118 NCBI chr 1:9,787,565...9,810,276
Ensembl chr 1:11,009,760...11,030,734 		JBrowse link
G MBL2 mannose binding lectin 2 involved_in
acts_upstream_of_or_within 		IEA UniProt
Ensembl		 GO_REF:0000043 GO_REF:0000107 NCBI chr10:49,401,364...49,409,328
Ensembl chr10:51,527,758...51,543,432 		JBrowse link
negative regulation of complement activation, lectin pathway term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G LOC100979269 alpha-2-macroglobulin involved_in IEA Ensembl GO_REF:0000107 NCBI chr12:9,154,457...9,202,833
Ensembl chr12:9,385,359...9,433,979 		JBrowse link
G SERPING1 serpin family G member 1 involved_in IEA Ensembl GO_REF:0000107 NCBI chr11:52,838,502...52,855,781
Ensembl chr11:56,309,686...56,326,639 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 19315
    immune system process 2524
      immune response 1638
        innate immune response 845
          complement activation, lectin pathway 11
            negative regulation of complement activation, lectin pathway 2
            positive regulation of complement activation, lectin pathway 0
            regulation of complement activation, lectin pathway + 2
Path 2
Term Annotations click to browse term
  biological_process 19315
    biological regulation 11855
      regulation of biological process 11474
        positive regulation of biological process 6453
          positive regulation of response to stimulus 2445
            positive regulation of immune response 758
              activation of immune response 558
                complement activation 52
                  complement activation, lectin pathway 11
                    negative regulation of complement activation, lectin pathway 2
                    positive regulation of complement activation, lectin pathway 0
                    regulation of complement activation, lectin pathway + 2
paths to the root