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ONTOLOGY REPORT - ANNOTATIONS

Term:complement activation, lectin pathway
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Accession:GO:0001867 term browser browse the term
Definition:Any process involved in the activation of any of the steps of the lectin pathway of the complement cascade which allows for the direct killing of microbes and the regulation of other immune processes.
Comment:Note that proteins such as mannose-binding lectin (MBL) and certain serum ficolins can activate the lectin complement pathway.
Synonyms:exact_synonym: complement cascade, lectin pathway
 xref: Reactome:R-HSA-166662 "Lectin pathway of complement activation"


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complement activation, lectin pathway term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G AABR07006691.1 involved_in
acts_upstream_of_or_within		 IEA GO_REF:0000043
GO_REF:0000107		 UniProt
Ensembl		 GO_REF:0000043 GO_REF:0000107 Ensembl chr 1:228,016,498...228,043,066 JBrowse link
G Cd69 Cd69 molecule TAS RGD PMID:11034393 PMID:15506986 RGD:1354527, RGD:1354528 NCBI chr 4:162,725,446...162,733,364
Ensembl chr 4:162,725,446...162,733,542 		JBrowse link
G Colec10 collectin subfamily member 10 involved_in ISO
IEA		 (PMID:24174618)
GO_REF:0000107		 RGD
Ensembl		 PMID:24174618 GO_REF:0000107 NCBI chr 7:85,744,895...85,806,368
Ensembl chr 7:85,744,895...85,805,675 		JBrowse link
G Colec11 collectin sub-family member 11 involved_in ISO (PMID:24174618), (PMID:25912189) RGD PMID:24174618 PMID:25912189 NCBI chr 6:45,223,974...45,256,640
Ensembl chr 6:45,223,980...45,271,145 		JBrowse link
G Fcna ficolin A involved_in IBA GO_REF:0000033 GO_Central GO_REF:0000033 NCBI chr 3:8,445,904...8,449,128
Ensembl chr 3:8,445,907...8,449,105 		JBrowse link
G Fcnb ficolin B involved_in ISO
IEA
IBA		 (PMID:16116205)
GO_REF:0000043
GO_REF:0000107
GO_REF:0000033		 RGD
UniProt
Ensembl
GO_Central		 PMID:16116205 GO_REF:0000033 GO_REF:0000043 GO_REF:0000107 NCBI chr 3:11,393,713...11,402,198
Ensembl chr 3:11,393,739...11,402,151 		JBrowse link
G Krt1 keratin 1 involved_in ISO
IEA		 UniProtKB:P11226 (PMID:11549596)
GO_REF:0000107		 RGD
Ensembl		 PMID:11549596 GO_REF:0000107 NCBI chr 7:132,976,618...132,981,844
Ensembl chr 7:132,976,620...132,981,844 		JBrowse link
G Masp1 MBL associated serine protease 1 involved_in ISS
IEA
ISO
IBA		 GO_REF:0000024
GO_REF:0000043
(PMID:18424734)
GO_REF:0000033
GO_REF:0000107
(PMID:17182967)		 UniProt
RGD
GO_Central
Ensembl		 PMID:17182967 PMID:18424734 GO_REF:0000024 GO_REF:0000033 GO_REF:0000043 GO_REF:0000107 NCBI chr11:77,334,794...77,405,271
Ensembl chr11:77,334,859...77,402,974 		JBrowse link
G Masp2 MBL associated serine protease 2 involved_in ISO
IBA
IEA		 (PMID:17182967), (PMID:9087411)
GO_REF:0000033
GO_REF:0000107		 RGD
GO_Central
Ensembl		 PMID:9087411 PMID:17182967 GO_REF:0000033 GO_REF:0000107 NCBI chr 5:159,035,892...159,049,561
Ensembl chr 5:159,035,911...159,049,580 		JBrowse link
G Mbl1 mannose binding lectin 1 involved_in
acts_upstream_of_or_within		 IDA
IEA
ISO		 GO_REF:0000043
MGI:96924 (PMID:15148336)		 UniProt
RGD		 PMID:15148336 PMID:16272342 GO_REF:0000043, RGD:1582134 NCBI chr16:17,029,146...17,035,187
Ensembl chr16:17,029,118...17,035,174 		JBrowse link
G Mbl2 mannose binding lectin 2 acts_upstream_of_or_within
involved_in		 ISO
IEA		 (PMID:15148336)
GO_REF:0000107
GO_REF:0000043
MGI:3577339|MGI:96923 (PMID:15148336)
UniProtKB:P04264 (PMID:11549596), (PMID:22691502), (PMID:35102342)		 RGD
Ensembl
UniProt		 PMID:11549596 PMID:15148336 PMID:22691502 PMID:35102342 GO_REF:0000043 GO_REF:0000107 NCBI chr 1:228,016,439...228,024,736 JBrowse link
negative regulation of complement activation, lectin pathway term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G A2m alpha-2-macroglobulin involved_in ISO (PMID:12538697) RGD PMID:12538697 NCBI chr 4:156,570,163...156,619,870
Ensembl chr 4:154,897,877...154,947,786 		JBrowse link
G Serping1 serpin family G member 1 involved_in ISS
ISO
IEA		 GO_REF:0000024
(PMID:10946292)
GO_REF:0000107		 UniProt
RGD
Ensembl		 PMID:10946292 GO_REF:0000024 GO_REF:0000107 NCBI chr 3:69,842,726...69,852,583
Ensembl chr 3:69,842,739...69,852,034 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 20558
    immune system process 3130
      immune response 2236
        innate immune response 1025
          complement activation, lectin pathway 13
            negative regulation of complement activation, lectin pathway 2
            positive regulation of complement activation, lectin pathway 0
            regulation of complement activation, lectin pathway + 2
Path 2
Term Annotations click to browse term
  biological_process 20558
    biological regulation 13833
      regulation of biological process 13394
        positive regulation of biological process 6766
          positive regulation of response to stimulus 2577
            positive regulation of immune response 833
              activation of immune response 598
                complement activation 66
                  complement activation, lectin pathway 13
                    negative regulation of complement activation, lectin pathway 2
                    positive regulation of complement activation, lectin pathway 0
                    regulation of complement activation, lectin pathway + 2
paths to the root