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ONTOLOGY REPORT - ANNOTATIONS

Term:natural killer cell differentiation
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Accession:GO:0001779 term browser browse the term
Definition:The process in which a relatively unspecialized cell acquires the specialized features of a natural killer cell.
Comment:Note that immunologists typically use the word 'development' to refer to cells of B or T cell lineages undergoing the process that GO describes as 'cell differentiation'.
Synonyms:exact_synonym: NK cell differentiation
 related_synonym: natural killer cell development


show annotations for term's descendants           Sort by:
natural killer cell differentiation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Axl Axl receptor tyrosine kinase involved_in
acts_upstream_of_or_within		 IBA
ISO		 GO_REF:0000033
MGI:104294|MGI:96965 (PMID:16751775)		 GO_Central
RGD		 PMID:16751775 GO_REF:0000033 NCBI chr 1:90,392,864...90,424,123
Ensembl chr 1:81,265,088...81,296,265 		JBrowse link
G Flt3lg Fms related receptor tyrosine kinase 3 ligand acts_upstream_of
involved_in		 ISO MGI:2158499 (PMID:14607906)
(PMID:38701783)		 RGD PMID:14607906 PMID:38701783 NCBI chr 1:104,751,518...104,756,925
Ensembl chr 1:95,609,370...95,620,463 		JBrowse link
G Hectd1 HECT domain E3 ubiquitin protein ligase 1 acts_upstream_of_or_within ISO MGI:2137552 (PMID:24855001) RGD PMID:24855001 NCBI chr 6:74,916,803...75,003,408
Ensembl chr 6:69,181,436...69,268,053 		JBrowse link
G Id2 inhibitor of DNA binding 2 acts_upstream_of_or_within ISO MGI:2384134|MGI:98510 (PMID:17452521) RGD PMID:17452521 NCBI chr 6:47,469,162...47,470,995
Ensembl chr 6:41,728,946...41,744,400 		JBrowse link
G Ikzf1 IKAROS family zinc finger 1 acts_upstream_of_or_within ISO MGI:2158738 (PMID:7923373) RGD PMID:7923373 NCBI chr14:90,468,696...90,556,522
Ensembl chr14:86,255,065...86,342,416 		JBrowse link
G Il11ra1 interleukin 11 receptor subunit alpha 1 acts_upstream_of_or_within ISO MGI:2177774 (PMID:15499555) RGD PMID:15499555 NCBI chr 5:61,727,650...61,737,265
Ensembl chr 5:56,935,516...56,941,408 		JBrowse link
G Il15 interleukin 15 acts_upstream_of ISO
IEA		 MGI:2136897 (PMID:14607906)
GO_REF:0000107		 RGD
Ensembl		 PMID:14607906 GO_REF:0000107 NCBI chr19:42,536,160...42,611,349
Ensembl chr19:25,640,251...25,706,820 		JBrowse link
G Il15ra interleukin 15 receptor subunit alpha acts_upstream_of ISO
IEA		 MGI:1934016 (PMID:14607906)
GO_REF:0000107		 RGD
Ensembl		 PMID:14607906 GO_REF:0000107 NCBI chr17:71,712,141...71,742,072
Ensembl chr17:66,802,334...66,832,278 		JBrowse link
G Il21 interleukin 21 acts_upstream_of ISO (PMID:14764669) RGD PMID:14764669 NCBI chr 2:122,045,240...122,055,142
Ensembl chr 2:120,119,444...120,126,996 		JBrowse link
G Kat7 lysine acetyltransferase 7 involved_in ISS
IEA
ISO		 GO_REF:0000024
GO_REF:0000107
(PMID:27733580)		 UniProt
Ensembl
RGD		 PMID:27733580 GO_REF:0000024 GO_REF:0000107 NCBI chr10:80,718,335...80,752,387
Ensembl chr10:80,221,524...80,255,567 		JBrowse link
G Kctd9 potassium channel tetramerization domain containing 9 acts_upstream_of_or_within ISO (PMID:31024568) RGD PMID:31024568 NCBI chr15:46,117,211...46,145,258
Ensembl chr15:41,942,381...41,969,862 		JBrowse link
G Mertk MER proto-oncogene, tyrosine kinase acts_upstream_of_or_within ISO
IEA		 MGI:104294|MGI:1347244 (PMID:16751775)
GO_REF:0000107		 RGD
Ensembl		 PMID:16751775 GO_REF:0000107 NCBI chr 3:136,391,936...136,498,366
Ensembl chr 3:115,939,351...116,046,554 		JBrowse link
G Nfil3 nuclear factor, interleukin 3 regulated involved_in ISS
ISO		 GO_REF:0000024
(PMID:32190943)		 UniProt
RGD		 PMID:32190943 GO_REF:0000024 NCBI chr17:12,432,376...12,447,605
Ensembl chr17:12,280,484...12,295,858 		JBrowse link
G Pbx1 PBX homeobox 1 involved_in ISO
IEA		 (PMID:32190943)
GO_REF:0000107		 RGD
Ensembl		 PMID:32190943 GO_REF:0000107 NCBI chr13:82,811,664...83,121,447
Ensembl chr13:80,278,770...80,588,594 		JBrowse link
G Ptprc protein tyrosine phosphatase, receptor type, C involved_in ISO (PMID:15557316) RGD PMID:15557316 NCBI chr13:52,147,717...52,259,810
Ensembl chr13:49,596,193...49,708,692 		JBrowse link
G Rabl3 RAB, member of RAS oncogene family-like 3 involved_in ISO
IEA		 (PMID:32220963)
GO_REF:0000107		 RGD
Ensembl		 PMID:32220963 GO_REF:0000107 NCBI chr11:76,658,723...76,687,681
Ensembl chr11:63,152,792...63,182,671 		JBrowse link
G Slamf1 signaling lymphocytic activation molecule family member 1 involved_in ISO
IEA		 (PMID:18031695)
GO_REF:0000107		 RGD
Ensembl		 PMID:18031695 GO_REF:0000107 NCBI chr13:86,802,708...86,837,890
Ensembl chr13:84,270,316...84,305,497 		JBrowse link
G Slamf6 SLAM family member 6 involved_in ISO (PMID:18031695) RGD PMID:18031695 NCBI chr13:86,916,956...86,937,697
Ensembl chr13:84,383,742...84,405,300 		JBrowse link
G Sp3 Sp3 transcription factor acts_upstream_of_or_within ISO
IEA		 MGI:2182438 (PMID:12676787)
GO_REF:0000107		 RGD
Ensembl		 PMID:12676787 GO_REF:0000107 NCBI chr 3:78,219,421...78,272,318
Ensembl chr 3:57,812,075...57,860,342 		JBrowse link
G Stat5a signal transducer and activator of transcription 5A acts_upstream_of_or_within ISO
IEA		 MGI:103035 (PMID:10072077)
GO_REF:0000107
MGI:1857249 (PMID:9841920)		 RGD
Ensembl		 PMID:9841920 PMID:10072077 GO_REF:0000107 NCBI chr10:86,285,859...86,310,187
Ensembl chr10:85,785,537...85,809,866 		JBrowse link
G Stat5b signal transducer and activator of transcription 5B acts_upstream_of_or_within ISO
IEA		 MGI:103036 (PMID:10072077)
GO_REF:0000107
MGI:2181592 (PMID:9841920)		 RGD
Ensembl		 PMID:9841920 PMID:10072077 GO_REF:0000107 NCBI chr10:86,205,148...86,276,178
Ensembl chr10:85,705,670...85,775,668 		JBrowse link
G Tcf3 transcription factor 3 acts_upstream_of_or_within ISO MGI:96397 (PMID:17452521) RGD PMID:17452521 NCBI chr 7:9,931,251...9,952,994
Ensembl chr 7:9,280,571...9,302,314 		JBrowse link
G Tox thymocyte selection-associated high mobility group box involved_in ISO
IEA		 (PMID:21126536)
GO_REF:0000107		 RGD
Ensembl		 PMID:21126536 GO_REF:0000107 NCBI chr 5:24,672,487...24,968,754
Ensembl chr 5:19,874,467...20,171,272 		JBrowse link
G Tusc2 tumor suppressor 2, mitochondrial calcium regulator acts_upstream_of_or_within ISO
IEA		 MGI:103014|MGI:3706236 (PMID:17318811)
GO_REF:0000107		 RGD
Ensembl		 PMID:17318811 GO_REF:0000107 NCBI chr 8:117,115,479...117,118,697
Ensembl chr 8:108,236,838...108,240,056 		JBrowse link
G Tyro3 TYRO3 protein tyrosine kinase acts_upstream_of_or_within ISO
IEA		 MGI:1347244|MGI:96965 (PMID:16751775)
GO_REF:0000107		 RGD
Ensembl		 PMID:16751775 GO_REF:0000107 NCBI chr 3:127,231,468...127,254,806
Ensembl chr 3:106,777,635...106,797,142 		JBrowse link
G Zfp683 zinc finger protein 683 acts_upstream_of_or_within ISO MGI:4276801 (PMID:22885984) RGD PMID:22885984 NCBI chr 5:151,558,880...151,569,937
Ensembl chr 5:146,278,978...146,285,000 		JBrowse link
negative regulation of natural killer cell differentiation involved in immune response term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Pglyrp1 peptidoglycan recognition protein 1 acts_upstream_of_or_within ISO MGI:2670590 (PMID:20709292) RGD PMID:20709292 NCBI chr 1:87,659,863...87,665,048
Ensembl chr 1:78,531,815...78,537,001 		JBrowse link
G Pglyrp2 peptidoglycan recognition protein 2 acts_upstream_of_or_within ISO
IEA		 MGI:5297105 (PMID:20709292)
GO_REF:0000107		 RGD
Ensembl		 PMID:20709292 GO_REF:0000107 NCBI chr 7:12,069,414...12,082,437
Ensembl chr 7:11,418,880...11,427,773 		JBrowse link
G Pglyrp3 peptidoglycan recognition protein 3 acts_upstream_of_or_within ISO MGI:5297106 (PMID:20709292) RGD PMID:20709292 NCBI chr 2:180,174,931...180,186,007
Ensembl chr 2:177,477,407...177,490,736
Ensembl chr 2:177,477,407...177,490,736 		JBrowse link
G Pglyrp4 peptidoglycan recognition protein 4 acts_upstream_of_or_within ISO MGI:5297107 (PMID:20709292) RGD PMID:20709292 NCBI chr 2:178,500,238...178,669,328
Ensembl chr 2:176,218,519...176,242,251 		JBrowse link
positive regulation of natural killer cell differentiation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Axl Axl receptor tyrosine kinase involved_in ISO (PMID:18840707) RGD PMID:18840707 NCBI chr 1:90,392,864...90,424,123
Ensembl chr 1:81,265,088...81,296,265 		JBrowse link
G Flt3lg Fms related receptor tyrosine kinase 3 ligand acts_upstream_of_or_within ISO MGI:2158499 (PMID:14607906) RGD PMID:14607906 NCBI chr 1:104,751,518...104,756,925
Ensembl chr 1:95,609,370...95,620,463 		JBrowse link
G Gas6 growth arrest specific 6 involved_in ISS
IEA
ISO		 GO_REF:0000024
GO_REF:0000107
(PMID:18840707)		 UniProt
Ensembl
RGD		 PMID:18840707 GO_REF:0000024 GO_REF:0000107 NCBI chr16:82,747,676...82,778,090
Ensembl chr16:76,045,426...76,075,904 		JBrowse link
G Il15 interleukin 15 acts_upstream_of_or_within ISO
IEA		 MGI:1931086|MGI:2136897 (PMID:14607906), (PMID:17318811)
GO_REF:0000107		 RGD
Ensembl		 PMID:14607906 PMID:17318811 GO_REF:0000107 NCBI chr19:42,536,160...42,611,349
Ensembl chr19:25,640,251...25,706,820 		JBrowse link
G Il15ra interleukin 15 receptor subunit alpha acts_upstream_of_or_within ISO
IEA		 MGI:1934016 (PMID:14607906)
GO_REF:0000107		 RGD
Ensembl		 PMID:14607906 GO_REF:0000107 NCBI chr17:71,712,141...71,742,072
Ensembl chr17:66,802,334...66,832,278 		JBrowse link
G Il21 interleukin 21 acts_upstream_of_or_within ISO (PMID:14764669) RGD PMID:14764669 NCBI chr 2:122,045,240...122,055,142
Ensembl chr 2:120,119,444...120,126,996 		JBrowse link
G Rasgrp1 RAS guanyl releasing protein 1 involved_in IEA
ISO		 GO_REF:0000107
(PMID:21957144)		 Ensembl
RGD		 PMID:21957144 GO_REF:0000107 NCBI chr 3:124,624,039...124,684,079
Ensembl chr 3:104,170,013...104,230,056 		JBrowse link
G Stat5a signal transducer and activator of transcription 5A acts_upstream_of_or_within ISO
IEA		 MGI:1857249 (PMID:9841920)
GO_REF:0000107		 RGD
Ensembl		 PMID:9841920 GO_REF:0000107 NCBI chr10:86,285,859...86,310,187
Ensembl chr10:85,785,537...85,809,866 		JBrowse link
G Stat5b signal transducer and activator of transcription 5B acts_upstream_of_or_within ISO
IEA		 MGI:2181592 (PMID:9841920)
GO_REF:0000107		 RGD
Ensembl		 PMID:9841920 GO_REF:0000107 NCBI chr10:86,205,148...86,276,178
Ensembl chr10:85,705,670...85,775,668 		JBrowse link
G Tox thymocyte selection-associated high mobility group box acts_upstream_of_or_within ISO
IEA		 MGI:3773716 (PMID:20818394)
GO_REF:0000107		 RGD
Ensembl		 PMID:20818394 GO_REF:0000107 NCBI chr 5:24,672,487...24,968,754
Ensembl chr 5:19,874,467...20,171,272 		JBrowse link
G Zbtb1 zinc finger and BTB domain containing 1 involved_in ISO
IEA		 (PMID:22753936)
GO_REF:0000107		 RGD
Ensembl		 PMID:22753936 GO_REF:0000107 NCBI chr 6:100,832,506...100,864,019
Ensembl chr 6:95,096,387...95,118,996 		JBrowse link
regulation of natural killer cell differentiation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Lgals9 galectin 9 involved_in ISO (PMID:23408620) RGD PMID:23408620 NCBI chr10:64,405,044...64,428,249
Ensembl chr10:63,907,018...63,930,045 		JBrowse link
G Prdm1 PR/SET domain 1 involved_in ISO
IEA		 (PMID:27102484)
GO_REF:0000107		 RGD
Ensembl		 PMID:27102484 GO_REF:0000107 NCBI chr20:49,542,465...49,564,088
Ensembl chr20:47,959,858...47,981,488 		JBrowse link
G Zfp683 zinc finger protein 683 involved_in ISO (PMID:27102484) RGD PMID:27102484 NCBI chr 5:151,558,880...151,569,937
Ensembl chr 5:146,278,978...146,285,000 		JBrowse link
regulation of natural killer cell differentiation involved in immune response term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Zfp683 zinc finger protein 683 involved_in ISO (PMID:22885984) RGD PMID:22885984 NCBI chr 5:151,558,880...151,569,937
Ensembl chr 5:146,278,978...146,285,000 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 20558
    immune system process 3130
      leukocyte activation 1082
        lymphocyte activation 875
          lymphocyte differentiation 453
            natural killer cell differentiation 35
              natural killer cell differentiation involved in immune response + 5
              negative regulation of natural killer cell differentiation + 4
              positive regulation of natural killer cell differentiation + 11
              regulation of natural killer cell differentiation + 18
Path 2
Term Annotations click to browse term
  biological_process 20558
    developmental process 7149
      cellular developmental process 4833
        cell differentiation 4832
          cell development 3350
            hemopoiesis 1083
              leukocyte differentiation 690
                mononuclear cell differentiation 556
                  lymphocyte differentiation 453
                    natural killer cell differentiation 35
                      natural killer cell differentiation involved in immune response + 5
                      negative regulation of natural killer cell differentiation + 4
                      positive regulation of natural killer cell differentiation + 11
                      regulation of natural killer cell differentiation + 18
paths to the root