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ONTOLOGY REPORT - ANNOTATIONS

Term:immunological synapse
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Accession:GO:0001772 term browser browse the term
Definition:An area of close contact between a lymphocyte (T-, B-, or natural killer cell) and a target cell formed through the clustering of particular signaling and adhesion molecules and their associated membrane rafts on both the lymphocyte and the target cell and facilitating activation of the lymphocyte, transfer of membrane from the target cell to the lymphocyte, and in some situations killing of the target cell through release of secretory granules and/or death-pathway ligand-receptor interaction.
Synonyms:exact_synonym: supramolecular activation cluster
 narrow_synonym: c-SMAC
 xref: Wikipedia:Immunological_synapse


show annotations for term's descendants           Sort by:
immunological synapse term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Alcam activated leukocyte cell adhesion molecule located_in ISO
ISS
IEA		 (PMID:15294938)
GO_REF:0000024
GO_REF:0000107		 RGD
UniProt
Ensembl		 PMID:15294938 GO_REF:0000024 GO_REF:0000107 NCBI chr11:48,336,123...48,536,296
Ensembl chr11:48,336,169...48,537,954 		JBrowse link
G Arhgdia Rho GDP dissociation inhibitor alpha located_in ISO (PMID:11728336) RGD PMID:11728336 NCBI chr10:105,854,526...105,858,020
Ensembl chr10:105,854,533...105,858,023 		JBrowse link
G Atp2b1 ATPase plasma membrane Ca2+ transporting 1 located_in ISS
ISO
IEA		 GO_REF:0000024
(MGI:6114568|PMID:28827723)
GO_REF:0000107
(PMID:28827723)		 UniProt
RGD
Ensembl		 PMID:28827723 GO_REF:0000024 GO_REF:0000107 MGI:6114568 NCBI chr 7:33,735,595...33,845,226
Ensembl chr 7:33,735,871...33,843,295 		JBrowse link
G Bcl10 BCL10, immune signaling adaptor located_in ISO (PMID:14724296) RGD PMID:14724296 NCBI chr 2:234,840,880...234,850,520
Ensembl chr 2:234,840,858...234,850,523 		JBrowse link
G Calhm6 calcium homeostasis modulator family member 6 located_in IEA
ISO		 GO_REF:0000107
(PMID:36861806)		 Ensembl
RGD		 PMID:36861806 GO_REF:0000107 NCBI chr20:26,095,591...26,097,336
Ensembl chr20:26,095,592...26,097,278 		JBrowse link
G Card11 caspase recruitment domain family, member 11 located_in ISO (PMID:23793062) RGD PMID:23793062 NCBI chr12:13,621,140...13,758,115
Ensembl chr12:13,621,087...13,758,112 		JBrowse link
G Carmil2 capping protein regulator and myosin 1 linker 2 located_in ISO (PMID:23793062) RGD PMID:23793062 NCBI chr19:33,571,255...33,586,783
Ensembl chr19:33,574,257...33,586,965 		JBrowse link
G Cd28 Cd28 molecule located_in ISO (PMID:23793062) RGD PMID:23793062 NCBI chr 9:62,166,324...62,194,674
Ensembl chr 9:62,166,192...62,194,685 		JBrowse link
G Cd37 CD37 molecule located_in ISO
IEA		 (PMID:21930792)
GO_REF:0000107		 RGD
Ensembl		 PMID:21930792 GO_REF:0000107 NCBI chr 1:95,719,171...95,724,662
Ensembl chr 1:95,719,190...95,724,648 		JBrowse link
G Cd3e CD3 epsilon subunit of T-cell receptor complex located_in ISO (PMID:14635057), (PMID:15064761) RGD PMID:14635057 PMID:15064761 NCBI chr 8:45,303,848...45,315,005
Ensembl chr 8:45,303,852...45,315,022 		JBrowse link
G Cd53 Cd53 molecule located_in ISO (PMID:21930792) RGD PMID:21930792 NCBI chr 2:194,352,139...194,399,668
Ensembl chr 2:194,352,139...194,399,657 		JBrowse link
G Cd6 Cd6 molecule located_in ISO (PMID:15294938) RGD PMID:15294938 NCBI chr 1:207,442,873...207,481,703
Ensembl chr 1:207,442,877...207,481,634 		JBrowse link
G Cd81 Cd81 molecule located_in ISO
ISS
IEA		 (PMID:21930792), (PMID:23858057)
GO_REF:0000024
GO_REF:0000107		 RGD
UniProt
Ensembl		 PMID:21930792 PMID:23858057 GO_REF:0000024 GO_REF:0000107 NCBI chr 1:198,235,861...198,251,660
Ensembl chr 1:198,241,484...198,251,660 		JBrowse link
G Coro1a coronin 1A located_in ISO (PMID:24760828)
(PMID:18199416)		 RGD PMID:18199416 PMID:24760828 NCBI chr 1:181,295,561...181,300,566
Ensembl chr 1:181,295,562...181,300,534 		JBrowse link
G Cracr2a calcium release activated channel regulator 2A located_in ISO (PMID:27016526) RGD PMID:27016526 NCBI chr 4:160,428,987...160,517,427
Ensembl chr 4:160,408,077...160,518,107 		JBrowse link
G Crtam cytotoxic and regulatory T cell molecule located_in ISO (MGI:3834299|PMID:18329370)
(PMID:18329370)		 RGD PMID:18329370 MGI:3834299 NCBI chr 8:41,340,117...41,377,381
Ensembl chr 8:41,340,837...41,377,343 		JBrowse link
G Dlg1 discs large MAGUK scaffold protein 1 located_in ISO
IEA		 (PMID:20551903)
GO_REF:0000107
(PMID:15699074)		 RGD
Ensembl		 PMID:15699074 PMID:20551903 GO_REF:0000107 NCBI chr11:68,911,883...69,103,230
Ensembl chr11:68,911,883...69,102,689 		JBrowse link
G Dusp3 dual specificity phosphatase 3 located_in ISO (PMID:12447358) RGD PMID:12447358 NCBI chr10:86,920,014...86,933,739
Ensembl chr10:86,920,014...86,933,962 		JBrowse link
G Ezr ezrin located_in IEA
ISO		 GO_REF:0000107
(PMID:17911601), (PMID:20551903)		 Ensembl
RGD		 PMID:17911601 PMID:20551903 GO_REF:0000107 NCBI chr 1:46,967,961...47,011,505
Ensembl chr 1:46,967,658...47,011,505 		JBrowse link
G Fyb2 FYN binding protein 2 located_in ISO (PMID:27335501) RGD PMID:27335501 NCBI chr 5:119,677,116...119,800,911
Ensembl chr 5:119,677,204...119,800,910 		JBrowse link
G Havcr2 hepatitis A virus cellular receptor 2 located_in ISO (MGI:5705214|PMID:24337741)
(PMID:24337741)		 RGD PMID:24337741 MGI:5705214 NCBI chr10:30,882,484...30,914,018
Ensembl chr10:30,882,606...30,909,137 		JBrowse link
G Icam1 intercellular adhesion molecule 1 located_in ISO (MGI:6838590|PMID:27359298), (PMID:14973438) RGD PMID:14973438 PMID:27359298 MGI:6838590 NCBI chr 8:19,553,063...19,565,438
Ensembl chr 8:19,553,645...19,565,438 		JBrowse link
G Il4i1 interleukin 4 induced 1 located_in ISO (PMID:28891065) RGD PMID:28891065 NCBI chr 1:95,299,457...95,324,564
Ensembl chr 1:95,295,601...95,324,562 		JBrowse link
G Itgal integrin subunit alpha L located_in ISO (PMID:15064761) RGD PMID:15064761 NCBI chr 1:181,918,183...181,955,735
Ensembl chr 1:181,918,183...181,955,732 		JBrowse link
G Lat linker for activation of T cells located_in
is_active_in		 ISO
IBA		 (PMID:12646565)
GO_REF:0000033
(PMID:14635057)		 RGD
GO_Central		 PMID:12646565 PMID:14635057 GO_REF:0000033 NCBI chr 1:180,936,536...180,941,561
Ensembl chr 1:180,936,534...180,941,578 		JBrowse link
G Lck LCK proto-oncogene, Src family tyrosine kinase located_in ISO
IEA		 (PMID:20007709)
GO_REF:0000107		 RGD
Ensembl		 PMID:20007709 GO_REF:0000107 NCBI chr 5:141,888,318...141,916,945
Ensembl chr 5:141,888,326...141,903,794 		JBrowse link
G Lgals3 galectin 3 located_in
is_active_in		 ISO
IEA
IBA		 (PMID:19706535)
(MGI:4355752|PMID:19706535)
GO_REF:0000107
GO_REF:0000033		 RGD
Ensembl
GO_Central		 PMID:19706535 GO_REF:0000033 GO_REF:0000107 MGI:4355752 NCBI chr15:20,620,083...20,632,019
Ensembl chr15:20,607,692...20,632,025 		JBrowse link
G Myh9 myosin, heavy chain 9 located_in ISO
IEA		 (PMID:15064761)
GO_REF:0000107		 RGD
Ensembl		 PMID:15064761 GO_REF:0000107 NCBI chr 7:109,343,718...109,424,457
Ensembl chr 7:109,343,706...109,424,457 		JBrowse link
G Nedd9 neural precursor cell expressed, developmentally down-regulated 9 located_in ISO (MGI:6838590|PMID:27359298)
(PMID:27359298)		 RGD PMID:27359298 MGI:6838590 NCBI chr17:23,289,793...23,468,026
Ensembl chr17:23,282,326...23,468,019 		JBrowse link
G Nptn neuroplastin located_in ISS
ISO
IEA		 GO_REF:0000024
(MGI:6114568|PMID:28827723)
GO_REF:0000107		 UniProt
RGD
Ensembl		 PMID:28827723 GO_REF:0000024 GO_REF:0000107 MGI:6114568 NCBI chr 8:58,996,873...59,063,402
Ensembl chr 8:58,996,887...59,063,401 		JBrowse link
G Pdcd6ip programmed cell death 6 interacting protein located_in ISO (PMID:19706535) RGD PMID:19706535 NCBI chr 8:113,590,998...113,646,795
Ensembl chr 8:113,590,998...113,646,773 		JBrowse link
G Prf1 perforin 1 located_in
is_active_in		 IEA
ISO		 GO_REF:0000107
(PMID:8164737)		 Ensembl
RGD		 PMID:8164737 GO_REF:0000107 NCBI chr20:29,246,202...29,251,712
Ensembl chr20:29,246,202...29,251,701 		JBrowse link
G Prkar1a protein kinase cAMP-dependent type I regulatory subunit alpha located_in IEA
ISO		 GO_REF:0000107
(PMID:17911601)		 Ensembl
RGD		 PMID:17911601 GO_REF:0000107 NCBI chr10:94,621,042...94,639,534
Ensembl chr10:94,620,039...94,639,041 		JBrowse link
G Prkcq protein kinase C, theta located_in IEA
ISO		 GO_REF:0000107
(PMID:11728336), (PMID:12867038), (PMID:15117976), (PMID:15128768), (PMID:23793062)		 Ensembl
RGD		 PMID:11728336 PMID:12867038 PMID:15117976 PMID:15128768 PMID:23793062 GO_REF:0000107 NCBI chr17:67,246,394...67,379,049
Ensembl chr17:67,246,394...67,378,704 		JBrowse link
G Ptprj protein tyrosine phosphatase, receptor type, J located_in ISO (PMID:12913111)
(MGI:4942249|PMID:12913111)		 RGD PMID:12913111 MGI:4942249 NCBI chr 3:76,405,917...76,561,842
Ensembl chr 3:76,405,927...76,562,260 		JBrowse link
G Rhoh ras homolog family member H located_in ISO (MGI:3686961|PMID:17028588)
(PMID:17028588)		 RGD PMID:17028588 MGI:3686961 NCBI chr14:42,341,135...42,371,971
Ensembl chr14:42,337,751...42,386,369 		JBrowse link
G RT1-Da RT1 class II, locus Da located_in ISO (PMID:15322540), (PMID:29884618) RGD PMID:15322540 PMID:29884618 NCBI chr20:4,513,464...4,518,457
Ensembl chr20:4,512,911...4,518,455 		JBrowse link
G RT1-Db1 RT1 class II, locus Db1 located_in ISO (PMID:15322540), (PMID:29884618) RGD PMID:15322540 PMID:29884618 NCBI chr20:4,548,664...4,558,237
Ensembl chr20:4,548,666...4,558,258 		JBrowse link
G Scimp SLP adaptor and CSK interacting membrane protein located_in
is_active_in		 ISO
IBA		 (PMID:21930792)
GO_REF:0000033		 RGD
GO_Central		 PMID:21930792 GO_REF:0000033 NCBI chr10:55,507,646...55,527,764
Ensembl chr10:55,507,519...55,528,171 		JBrowse link
G Scrib scribble planar cell polarity protein located_in ISO (MGI:3834299|PMID:18329370)
(PMID:18329370)		 RGD PMID:18329370 MGI:3834299 NCBI chr 7:107,759,343...107,782,364
Ensembl chr 7:107,759,343...107,782,331 		JBrowse link
G Skap1 src kinase associated phosphoprotein 1 located_in ISO
IEA		 (PMID:12652296)
GO_REF:0000107		 RGD
Ensembl		 PMID:12652296 GO_REF:0000107 NCBI chr10:81,425,472...81,732,651
Ensembl chr10:81,425,525...81,732,650 		JBrowse link
G Snx27 sorting nexin 27 located_in ISS
IEA
ISO		 GO_REF:0000024
GO_REF:0000107
(PMID:17644068)		 UniProt
Ensembl
RGD		 PMID:17644068 GO_REF:0000024 GO_REF:0000107 NCBI chr 2:182,135,904...182,218,906
Ensembl chr 2:182,135,905...182,218,906 		JBrowse link
G Socs6 suppressor of cytokine signaling 6 located_in ISO (PMID:20007709) RGD PMID:20007709 NCBI chr18:82,111,866...82,139,193
Ensembl chr18:82,111,827...82,139,219 		JBrowse link
G Stoml2 stomatin like 2 located_in ISO
ISS		 (PMID:22623988)
GO_REF:0000024		 RGD
UniProt		 PMID:22623988 GO_REF:0000024 NCBI chr 5:57,256,227...57,259,824
Ensembl chr 5:57,256,220...57,259,920 		JBrowse link
G Stx7 syntaxin 7 located_in ISO
IEA		 (PMID:21438968)
GO_REF:0000107		 RGD
Ensembl		 PMID:21438968 GO_REF:0000107 NCBI chr 1:21,197,075...21,237,320
Ensembl chr 1:21,197,075...21,237,279 		JBrowse link
G Vav3 vav guanine nucleotide exchange factor 3 part_of ISO (PMID:15708849) RGD PMID:15708849 NCBI chr 2:197,011,901...197,354,321
Ensembl chr 2:197,011,831...197,354,321 		JBrowse link
G Zap70 zeta chain of T cell receptor associated protein kinase 70 located_in ISO (MGI:3686961|PMID:17028588)
(PMID:17028588)		 RGD PMID:17028588 MGI:3686961 NCBI chr 9:38,989,750...39,011,701
Ensembl chr 9:38,989,750...39,011,700 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  cellular_component 20814
    cellular anatomical structure 20574
      immunological synapse 47
Path 2
Term Annotations click to browse term
  cellular_component 20814
    cellular anatomical structure 20574
      membrane 10308
        plasma membrane 6433
          immunological synapse 47
paths to the root