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ONTOLOGY REPORT - ANNOTATIONS


Term:immunological synapse formation
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Accession:GO:0001771 term browser browse the term
Definition:The formation of an area of close contact between a lymphocyte (T-, B-, or natural killer cell) and a target cell through the clustering of particular signaling and adhesion molecules and their associated membrane rafts on both the lymphocyte and target cell, which facilitates activation of the lymphocyte, transfer of membrane from the target cell to the lymphocyte, and in some situations killing of the target cell through release of secretory granules and/or death-pathway ligand-receptor interaction.
Synonyms:exact_synonym: formation of immunological synapse


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immunological synapse formation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ccl19 C-C motif chemokine ligand 19 involved_in ISO (PMID:15845453) BHF-UCL PMID:15845453 NCBI chrNW_004936524:2,765,271...2,767,259
Ensembl chrNW_004936524:2,765,267...2,767,385
JBrowse link
G Ccl21 C-C motif chemokine ligand 21 involved_in ISO (PMID:15845453) BHF-UCL PMID:15845453 NCBI chrNW_004936524:2,787,963...2,789,116
Ensembl chrNW_004936524:2,788,341...2,789,016
JBrowse link
G Cd2ap CD2 associated protein involved_in
acts_upstream_of_or_within
IEA
ISO
(PMID:14512504) Ensembl
MGI
PMID:14512504 GO_REF:0000107 NCBI chrNW_004936476:12,890,595...12,989,046
Ensembl chrNW_004936476:12,890,468...12,987,843
JBrowse link
G Cd6 CD6 molecule involved_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004936581:1,932,596...1,943,671
Ensembl chrNW_004936581:1,932,668...1,969,126
JBrowse link
G Cd81 CD81 molecule involved_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004936794:664,089...670,294
Ensembl chrNW_004936794:664,115...669,800
JBrowse link
G Coro1a coronin 1A NOT|involved_in ISO (PMID:24760828) UniProt PMID:24760828 NCBI chrNW_004936501:12,338,542...12,344,236
Ensembl chrNW_004936501:12,338,542...12,344,265
JBrowse link
G Dlg1 discs large MAGUK scaffold protein 1 involved_in
acts_upstream_of_or_within
IEA
ISO
(PMID:15699074) Ensembl
MGI
PMID:15699074 GO_REF:0000107 NCBI chrNW_004936833:551,989...843,064
Ensembl chrNW_004936833:551,799...844,121
JBrowse link
G Dock2 dedicator of cytokinesis 2 involved_in
acts_upstream_of_or_within
IEA
ISO
(PMID:12871644) Ensembl
MGI
PMID:12871644 GO_REF:0000107 NCBI chrNW_004936609:4,695,202...5,099,038
Ensembl chrNW_004936609:4,695,628...5,099,038
JBrowse link
G Dock8 dedicator of cytokinesis 8 acts_upstream_of_or_within
involved_in
ISO
IEA
(PMID:22006977) MGI
Ensembl
PMID:22006977 GO_REF:0000107 NCBI chrNW_004936503:4,362,573...4,575,307
Ensembl chrNW_004936503:4,363,926...4,574,932
JBrowse link
G Ephb1 EPH receptor B1 acts_upstream_of_or_within ISO PMID:17310244 MGI PMID:17310244 RGD:10047256 NCBI chrNW_004936529:8,006,780...8,261,923
Ensembl chrNW_004936529:7,839,768...8,261,942
JBrowse link
G Git1 GIT ArfGAP 1 acts_upstream_of_or_within ISO PMID:17310244 MGI PMID:17310244 RGD:10047256 NCBI chrNW_004936538:5,684,660...5,694,779
Ensembl chrNW_004936538:5,684,644...5,695,043
JBrowse link
G Msn moesin involved_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004936635:2,390,390...2,461,870
Ensembl chrNW_004936635:2,389,823...2,461,930
JBrowse link
G Nck2 NCK adaptor protein 2 acts_upstream_of_or_within ISO PMID:17310244 MGI PMID:17310244 RGD:10047256 NCBI chrNW_004936764:141,159...185,482
Ensembl chrNW_004936764:140,946...185,529
JBrowse link
G Prf1 perforin 1 involved_in IEA TreeGrafter
Ensembl
GO_REF:0000107 GO_REF:0000118 NCBI chrNW_004936521:8,057,874...8,060,695
Ensembl chrNW_004936521:8,057,874...8,060,695
JBrowse link
negative regulation of immunological synapse formation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Havcr2 hepatitis A virus cellular receptor 2 involved_in ISO (PMID:24337741) UniProt PMID:24337741 NCBI chrNW_004936515:6,001,324...6,015,407 JBrowse link
G Lgals3 galectin 3 involved_in ISO (PMID:19706535) BHF-UCL PMID:19706535 NCBI chrNW_004936697:20,861...38,568
Ensembl chrNW_004936697:27,145...38,586
JBrowse link
positive regulation of glycoprotein biosynthetic process involved in immunological synapse formation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ccr7 C-C motif chemokine receptor 7 involved_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004936490:15,575,764...15,579,766
Ensembl chrNW_004936490:15,575,764...15,579,757
JBrowse link
positive regulation of immunological synapse formation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ccr7 C-C motif chemokine receptor 7 involved_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004936490:15,575,764...15,579,766
Ensembl chrNW_004936490:15,575,764...15,579,757
JBrowse link
G Nedd9 neural precursor cell expressed, developmentally down-regulated 9 involved_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004936534:1,816,755...1,863,200
Ensembl chrNW_004936534:1,760,142...1,863,565
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 17411
    cellular process 17014
      cell recognition 145
        cell-cell recognition 72
          immunological synapse formation 18
            negative regulation of immunological synapse formation 2
            positive regulation of glycoprotein biosynthetic process involved in immunological synapse formation 1
            positive regulation of immunological synapse formation 2
            regulation of immunological synapse formation + 4
Path 2
Term Annotations click to browse term
  biological_process 17411
    cellular process 17014
      cell activation 1088
        leukocyte activation 943
          lymphocyte activation 769
            immunological synapse formation 18
              negative regulation of immunological synapse formation 2
              positive regulation of glycoprotein biosynthetic process involved in immunological synapse formation 1
              positive regulation of immunological synapse formation 2
              regulation of immunological synapse formation + 4
paths to the root