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ONTOLOGY REPORT - ANNOTATIONS

Term:immunological synapse formation
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Accession:GO:0001771 term browser browse the term
Definition:The formation of an area of close contact between a lymphocyte (T-, B-, or natural killer cell) and a target cell through the clustering of particular signaling and adhesion molecules and their associated membrane rafts on both the lymphocyte and target cell, which facilitates activation of the lymphocyte, transfer of membrane from the target cell to the lymphocyte, and in some situations killing of the target cell through release of secretory granules and/or death-pathway ligand-receptor interaction.
Synonyms:exact_synonym: formation of immunological synapse


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immunological synapse formation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ccl19 C-C motif chemokine ligand 19 involved_in ISO (PMID:15845453) RGD PMID:15845453 NCBI chr 5:56,963,364...56,965,308 JBrowse link
G Ccl21 C-C motif chemokine ligand 21 involved_in ISO (PMID:15845453) RGD PMID:15845453 NCBI chr 5:56,980,557...56,981,661 JBrowse link
G Cd2ap CD2-associated protein involved_in
acts_upstream_of_or_within		 IEA
ISO		 GO_REF:0000107
MGI:2664945 (PMID:14512504)		 Ensembl
RGD		 PMID:14512504 GO_REF:0000107 NCBI chr 9:18,086,744...18,182,744 JBrowse link
G Cd6 Cd6 molecule involved_in ISO (PMID:15294938) RGD PMID:15294938 NCBI chr 1:207,442,873...207,481,703 JBrowse link
G Cd81 Cd81 molecule involved_in ISS
ISO
IEA		 GO_REF:0000024
(PMID:23858057)
GO_REF:0000107		 UniProt
RGD
Ensembl		 PMID:23858057 GO_REF:0000024 GO_REF:0000107 NCBI chr 1:207,665,274...207,681,094 JBrowse link
G Coro1a coronin 1A NOT|involved_in ISO (PMID:24760828) RGD PMID:24760828 NCBI chr 1:181,295,561...181,300,566 JBrowse link
G Dlg1 discs large MAGUK scaffold protein 1 involved_in
acts_upstream_of_or_within		 IEA
ISO		 GO_REF:0000107
(PMID:15699074)		 Ensembl
RGD		 PMID:15699074 GO_REF:0000107 NCBI chr11:82,416,853...82,607,797 JBrowse link
G Dock2 dedicator of cytokinesis 2 acts_upstream_of_or_within ISO MGI:2152031 (PMID:12871644) RGD PMID:12871644 NCBI chr10:19,331,412...19,748,987 JBrowse link
G Dock8 dedicator of cytokinesis 8 acts_upstream_of_or_within ISO MGI:3835421 (PMID:22006977) RGD PMID:22006977 NCBI chr 1:232,075,468...232,268,830 JBrowse link
G Ephb1 Eph receptor B1 acts_upstream_of_or_within IGI PMID:17310244 MGI PMID:17310244 PMID:17310244 RGD:10047256, RGD:10047256 NCBI chr 8:111,386,432...111,823,759 JBrowse link
G Git1 GIT ArfGAP 1 acts_upstream_of_or_within IGI PMID:17310244 MGI PMID:17310244 PMID:17310244 RGD:10047256, RGD:10047256 NCBI chr10:62,342,082...62,356,379 JBrowse link
G Msn moesin involved_in ISO
IEA
ISS		 (PMID:27405666)
GO_REF:0000107
GO_REF:0000024		 RGD
Ensembl
UniProt		 PMID:27405666 GO_REF:0000024 GO_REF:0000107 NCBI chr  X:60,996,043...61,064,011 JBrowse link
G Nck2 NCK adaptor protein 2 acts_upstream_of_or_within IGI PMID:17310244 MGI PMID:17310244 PMID:17310244 RGD:10047256, RGD:10047256 NCBI chr 9:53,206,006...53,332,417 JBrowse link
G Prf1 perforin 1 involved_in ISO
IBA
IEA		 (PMID:21438968)
GO_REF:0000033
GO_REF:0000107		 RGD
GO_Central
Ensembl		 PMID:21438968 GO_REF:0000033 GO_REF:0000107 NCBI chr20:29,246,202...29,251,712 JBrowse link
negative regulation of immunological synapse formation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Havcr2 hepatitis A virus cellular receptor 2 involved_in ISO (PMID:24337741) RGD PMID:24337741 NCBI chr10:30,882,484...30,914,018 JBrowse link
G Lgals3 galectin 3 involved_in ISO (PMID:19706535) RGD PMID:19706535 NCBI chr15:20,620,083...20,632,019 JBrowse link
positive regulation of glycoprotein biosynthetic process involved in immunological synapse formation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ccr7 C-C motif chemokine receptor 7 involved_in ISO (PMID:15845453) RGD PMID:15845453 NCBI chr10:84,098,193...84,108,309 JBrowse link
positive regulation of immunological synapse formation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ccr7 C-C motif chemokine receptor 7 involved_in ISO (PMID:15845453) RGD PMID:15845453 NCBI chr10:84,098,193...84,108,309 JBrowse link
G Nedd9 neural precursor cell expressed, developmentally down-regulated 9 involved_in ISO (PMID:27359298) RGD PMID:27359298 NCBI chr17:23,289,793...23,468,026 JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 20534
    cellular process 19523
      cell recognition 162
        cell-cell recognition 82
          immunological synapse formation 18
            negative regulation of immunological synapse formation 2
            positive regulation of glycoprotein biosynthetic process involved in immunological synapse formation 1
            positive regulation of immunological synapse formation 2
            regulation of immunological synapse formation + 4
Path 2
Term Annotations click to browse term
  biological_process 20534
    cellular process 19523
      cell activation 1226
        leukocyte activation 1070
          lymphocyte activation 867
            immunological synapse formation 18
              negative regulation of immunological synapse formation 2
              positive regulation of glycoprotein biosynthetic process involved in immunological synapse formation 1
              positive regulation of immunological synapse formation 2
              regulation of immunological synapse formation + 4
paths to the root