Send us a Message
Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   
Search RGD Grant Resources Citing RGD About Us Contact Us
Genes Variants Community Projects QTLs Strains Markers Genome Information Ontologies Cell Lines References Download Submit Data
OntoMate (Literature Search) JBrowse (Genome Browser) Synteny Browser (VCMap) Variant Visualizer Multi-Ontology Enrichment (MOET) Gene-Ortholog Location Finder (GOLF) InterViewer (Protein-Protein Interactions) PhenoMiner (Quatitative Phenotypes) Gene Annotator OLGA (Gene List Generator) AllianceMine GViewer (Genome Viewer)
Aging & Age-Related Disease Behavioral & Substance Use Disorder Cancer & Neoplastic Disease Cardiovascular Disease Coronavirus Disease Developmental Disease Diabetes Hematologic Disease Immune & Inflammatory Disease Infectious Disease Liver Disease Neurological Disease Obesity & Metabolic Syndrome Renal Disease Respiratory Disease Sensory Organ Disease
Find Models Genetic Models Autism Models Rat PhenoMiner (Quantitative Phenotypes) Chinchilla PhenoMiner Expected Ranges (Quantitative Phenotype) PhenoMiner Term Comparison Hybrid Rat Diversity Panel Phenotypes Phenotypes in Other Animal Models Animal Husbandry Strain Medical Records Phylogenetics Strain Availability Calendar Rats 101 Submissions Photo Archive
Pathways
Rat Community Forum Directory of Rat Laboratories Video Tutorials News RGD Publications RGD Presentations Archive Nomenclature Guidelines Resource Links Laboratory Resources Employment Resources
Advanced Search (OLGA)

ONTOLOGY REPORT - ANNOTATIONS

Term:immunological synapse formation
go back to main search page
Accession:GO:0001771 term browser browse the term
Definition:The formation of an area of close contact between a lymphocyte (T-, B-, or natural killer cell) and a target cell through the clustering of particular signaling and adhesion molecules and their associated membrane rafts on both the lymphocyte and target cell, which facilitates activation of the lymphocyte, transfer of membrane from the target cell to the lymphocyte, and in some situations killing of the target cell through release of secretory granules and/or death-pathway ligand-receptor interaction.
Synonyms:exact_synonym: formation of immunological synapse


show annotations for term's descendants           Sort by:
immunological synapse formation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ccl19 C-C motif chemokine ligand 19 involved_in ISO (PMID:15845453) RGD PMID:15845453 NCBI chr 5:61,759,220...61,761,164
Ensembl chr 5:61,759,220...61,772,022 		JBrowse link
G Ccl21 C-C motif chemokine ligand 21 involved_in ISO (PMID:15845453) RGD PMID:15845453 NCBI chr 5:61,776,411...61,777,515
Ensembl chr 5:61,776,413...61,777,540 		JBrowse link
G Cd2ap CD2-associated protein acts_upstream_of_or_within ISO MGI:2664945 (PMID:14512504) RGD PMID:14512504 NCBI chr 9:25,580,071...25,679,968
Ensembl chr 9:25,583,975...25,679,968 		JBrowse link
G Cd6 Cd6 molecule involved_in ISO
IEA 		(PMID:15294938)
GO_REF:0000107 		RGD
Ensembl		 PMID:15294938 GO_REF:0000107 NCBI chr 1:216,867,767...216,906,642
Ensembl chr 1:216,867,771...216,879,432 		JBrowse link
G Cd81 Cd81 molecule involved_in ISS
ISO 		GO_REF:0000024
(PMID:23858057) 		UniProt
RGD		 PMID:23858057 GO_REF:0000024 NCBI chr 1:207,665,274...207,681,094
Ensembl chr 1:207,664,885...207,681,092 		JBrowse link
G Coro1a coronin 1A NOT|involved_in ISO (PMID:24760828) RGD PMID:24760828 NCBI chr 1:190,726,129...190,731,133
Ensembl chr 1:190,726,130...190,731,102 		JBrowse link
G Dlg1 discs large MAGUK scaffold protein 1 acts_upstream_of_or_within IEA
ISO 		GO_REF:0000107
(PMID:15699074) 		Ensembl
RGD		 PMID:15699074 GO_REF:0000107 NCBI chr11:82,416,853...82,607,797
Ensembl chr11:82,416,853...82,607,797 		JBrowse link
G Dock2 dedicator of cytokinesis 2 acts_upstream_of_or_within IEA
ISO 		GO_REF:0000107
MGI:2152031 (PMID:12871644) 		Ensembl
RGD		 PMID:12871644 GO_REF:0000107 NCBI chr10:19,331,412...19,748,987
Ensembl chr10:19,331,412...19,748,969 		JBrowse link
G Dock8 dedicator of cytokinesis 8 acts_upstream_of_or_within IEA
ISO 		GO_REF:0000107
MGI:3835421 (PMID:22006977) 		Ensembl
RGD		 PMID:22006977 GO_REF:0000107 NCBI chr 1:232,075,468...232,268,830
Ensembl chr 1:232,075,588...232,268,833 		JBrowse link
G Ephb1 Eph receptor B1 acts_upstream_of_or_within IGI PMID:17310244 MGI PMID:17310244 PMID:17310244 RGD:10047256, RGD:10047256 NCBI chr 8:111,386,432...111,823,759
Ensembl chr 8:111,386,432...111,823,759 		JBrowse link
G Git1 GIT ArfGAP 1 acts_upstream_of_or_within IGI PMID:17310244 MGI PMID:17310244 PMID:17310244 RGD:10047256, RGD:10047256 NCBI chr10:62,840,165...62,854,508
Ensembl chr10:62,840,394...62,854,508 		JBrowse link
G Msn moesin involved_in ISO
IEA
ISS 		(PMID:27405666)
GO_REF:0000107
GO_REF:0000024 		RGD
Ensembl
UniProt		 PMID:27405666 GO_REF:0000024 GO_REF:0000107 NCBI chr  X:65,005,546...65,073,512
Ensembl chr  X:65,005,458...65,075,129 		JBrowse link
G Nck2 NCK adaptor protein 2 acts_upstream_of_or_within IGI PMID:17310244 MGI PMID:17310244 PMID:17310244 RGD:10047256, RGD:10047256 NCBI chr 9:53,206,006...53,332,417
Ensembl chr 9:53,231,381...53,332,394 		JBrowse link
G Prf1 perforin 1 involved_in ISO
IBA
IEA 		(PMID:21438968)
GO_REF:0000033
GO_REF:0000107 		RGD
GO_Central
Ensembl		 PMID:21438968 GO_REF:0000033 GO_REF:0000107 NCBI chr20:29,789,040...29,794,550
Ensembl chr20:29,788,972...29,795,124 		JBrowse link
negative regulation of immunological synapse formation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Havcr2 hepatitis A virus cellular receptor 2 involved_in ISO (PMID:24337741) RGD PMID:24337741 NCBI chr10:31,383,801...31,415,334
Ensembl chr10:31,383,925...31,413,872 		JBrowse link
G Lgals3 galectin 3 involved_in ISO (PMID:19706535) RGD PMID:19706535 NCBI chr15:23,099,795...23,111,731
Ensembl chr15:23,086,841...23,111,737 		JBrowse link
positive regulation of glycoprotein biosynthetic process involved in immunological synapse formation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ccr7 C-C motif chemokine receptor 7 involved_in IEA
ISO 		GO_REF:0000107
(PMID:15845453) 		Ensembl
RGD		 PMID:15845453 GO_REF:0000107 NCBI chr10:84,594,399...84,604,514
Ensembl chr10:84,593,594...84,604,501 		JBrowse link
positive regulation of immunological synapse formation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ccr7 C-C motif chemokine receptor 7 involved_in IEA
ISO 		GO_REF:0000107
(PMID:15845453) 		Ensembl
RGD		 PMID:15845453 GO_REF:0000107 NCBI chr10:84,594,399...84,604,514
Ensembl chr10:84,593,594...84,604,501 		JBrowse link
G Nedd9 neural precursor cell expressed, developmentally down-regulated 9 involved_in ISO (PMID:27359298) RGD PMID:27359298 NCBI chr17:23,495,531...23,673,780
Ensembl chr17:23,495,492...23,675,668 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 19315
    cellular process 18484
      cell recognition 174
        cell-cell recognition 86
          immunological synapse formation 18
            negative regulation of immunological synapse formation 2
            positive regulation of glycoprotein biosynthetic process involved in immunological synapse formation 1
            positive regulation of immunological synapse formation 2
            regulation of immunological synapse formation + 4
Path 2
Term Annotations click to browse term
  biological_process 19315
    cellular process 18484
      cell activation 1226
        leukocyte activation 1068
          lymphocyte activation 867
            immunological synapse formation 18
              negative regulation of immunological synapse formation 2
              positive regulation of glycoprotein biosynthetic process involved in immunological synapse formation 1
              positive regulation of immunological synapse formation 2
              regulation of immunological synapse formation + 4
paths to the root