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ONTOLOGY REPORT - ANNOTATIONS


Term:immunological synapse formation
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Accession:GO:0001771 term browser browse the term
Definition:The formation of an area of close contact between a lymphocyte (T-, B-, or natural killer cell) and a target cell through the clustering of particular signaling and adhesion molecules and their associated membrane rafts on both the lymphocyte and target cell, which facilitates activation of the lymphocyte, transfer of membrane from the target cell to the lymphocyte, and in some situations killing of the target cell through release of secretory granules and/or death-pathway ligand-receptor interaction.
Synonyms:exact_synonym: formation of immunological synapse



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immunological synapse formation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G CCL19 C-C motif chemokine ligand 19 involved_in ISO (PMID:15845453) BHF-UCL PMID:15845453 NCBI chr10:32,110,366...32,112,529
Ensembl chr10:32,110,065...32,112,734
JBrowse link
G CCL21 C-C motif chemokine ligand 21 involved_in ISO (PMID:15845453) BHF-UCL PMID:15845453 NCBI chr10:32,093,783...32,094,482
Ensembl chr10:32,093,763...32,096,224
JBrowse link
G CD2AP CD2 associated protein involved_in
acts_upstream_of_or_within
IEA
ISO
(PMID:14512504) Ensembl
MGI
PMID:14512504 GO_REF:0000107 NCBI chr 7:42,218,016...42,332,523
Ensembl chr 7:42,218,290...42,332,518
JBrowse link
G CD6 CD6 molecule involved_in IEA Ensembl GO_REF:0000107 NCBI chr 2:10,739,560...10,785,548
Ensembl chr 2:10,738,471...10,785,516
JBrowse link
G CD81 CD81 molecule involved_in IEA Ensembl GO_REF:0000107 NCBI chr 2:1,625,728...1,641,662
Ensembl chr 2:1,625,736...1,641,663
JBrowse link
G CORO1A coronin 1A NOT|involved_in ISO (PMID:24760828) UniProt PMID:24760828 NCBI chr 3:18,336,813...18,342,381
Ensembl chr 3:18,336,898...18,342,396
JBrowse link
G DLG1 discs large MAGUK scaffold protein 1 involved_in
acts_upstream_of_or_within
IEA
ISO
(PMID:15699074) Ensembl
MGI
PMID:15699074 GO_REF:0000107 NCBI chr13:132,819,931...133,084,880
Ensembl chr13:132,820,870...133,086,841
JBrowse link
G DOCK2 dedicator of cytokinesis 2 involved_in
acts_upstream_of_or_within
IEA
ISO
(PMID:12871644) Ensembl
MGI
PMID:12871644 GO_REF:0000107 NCBI chr16:53,843,248...54,248,708
Ensembl chr16:53,843,252...54,248,638
JBrowse link
G DOCK8 dedicator of cytokinesis 8 involved_in
acts_upstream_of_or_within
IEA
ISO
(PMID:22006977) Ensembl
MGI
PMID:22006977 GO_REF:0000107 NCBI chr 1:221,257,771...221,491,889
Ensembl chr 1:221,256,009...221,491,953
JBrowse link
G EPHB1 EPH receptor B1 acts_upstream_of_or_within ISO PMID:17310244 MGI PMID:17310244 RGD:10047256 NCBI chr13:75,904,678...76,351,540
Ensembl chr13:75,905,676...76,345,534
JBrowse link
G GIT1 GIT ArfGAP 1 acts_upstream_of_or_within ISO PMID:17310244 MGI PMID:17310244 RGD:10047256 NCBI chr12:45,768,172...45,783,652
Ensembl chr12:45,768,176...45,783,658
JBrowse link
G MSN moesin involved_in ISS
IEA
UniProt
Ensembl
GO_REF:0000024 GO_REF:0000107 NCBI chr  X:51,844,197...51,967,674
Ensembl chr  X:51,844,156...51,970,107
JBrowse link
G NCK2 NCK adaptor protein 2 acts_upstream_of_or_within ISO PMID:17310244 MGI PMID:17310244 RGD:10047256 NCBI chr 3:49,063,813...49,222,274
Ensembl chr 3:49,063,991...49,198,664
JBrowse link
G PRF1 perforin 1 involved_in IEA
IBA
Ensembl
GO_Central
GO_REF:0000033 GO_REF:0000107 NCBI chr14:73,515,306...73,520,256
Ensembl chr14:73,512,769...73,520,202
JBrowse link
negative regulation of immunological synapse formation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G HAVCR2 hepatitis A virus cellular receptor 2 involved_in IEA Ensembl GO_REF:0000107 NCBI chr16:66,138,157...66,160,568
Ensembl chr16:66,139,535...66,160,538
JBrowse link
G LGALS3 galectin 3 involved_in ISO (PMID:19706535) BHF-UCL PMID:19706535 NCBI chr 1:184,478,639...184,496,155
Ensembl chr 1:184,478,710...184,497,951
JBrowse link
positive regulation of glycoprotein biosynthetic process involved in immunological synapse formation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G CCR7 C-C motif chemokine receptor 7 involved_in IEA Ensembl GO_REF:0000107 NCBI chr12:21,857,286...21,869,211
Ensembl chr12:21,857,286...21,872,475
JBrowse link
positive regulation of immunological synapse formation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G CCR7 C-C motif chemokine receptor 7 involved_in IEA Ensembl GO_REF:0000107 NCBI chr12:21,857,286...21,869,211
Ensembl chr12:21,857,286...21,872,475
JBrowse link
G NEDD9 neural precursor cell expressed, developmentally down-regulated 9 involved_in IEA Ensembl GO_REF:0000107 NCBI chr 7:7,807,042...8,093,553
Ensembl chr 7:7,807,044...7,914,061
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 18932
    cellular process 18474
      cell recognition 154
        cell-cell recognition 80
          immunological synapse formation 18
            negative regulation of immunological synapse formation 2
            positive regulation of glycoprotein biosynthetic process involved in immunological synapse formation 1
            positive regulation of immunological synapse formation 2
            regulation of immunological synapse formation + 4
Path 2
Term Annotations click to browse term
  biological_process 18932
    cellular process 18474
      cell activation 1201
        leukocyte activation 1052
          lymphocyte activation 864
            immunological synapse formation 18
              negative regulation of immunological synapse formation 2
              positive regulation of glycoprotein biosynthetic process involved in immunological synapse formation 1
              positive regulation of immunological synapse formation 2
              regulation of immunological synapse formation + 4
paths to the root