ONTOLOGY REPORT - ANNOTATIONS
Term: immunological synapse formation
Accession: GO:0001771
browse the term
Definition: The formation of an area of close contact between a lymphocyte (T-, B-, or natural killer cell) and a target cell through the clustering of particular signaling and adhesion molecules and their associated membrane rafts on both the lymphocyte and target cell, which facilitates activation of the lymphocyte, transfer of membrane from the target cell to the lymphocyte, and in some situations killing of the target cell through release of secretory granules and/or death-pathway ligand-receptor interaction.
Synonyms: exact_synonym: formation of immunological synapse
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CCL19
C-C motif chemokine ligand 19
involved_in
ISO
(PMID:15845453)
BHF-UCL
PMID:15845453
NCBI chr10:32,110,366...32,112,529
Ensembl chr10:32,110,065...32,112,734
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CCL21
C-C motif chemokine ligand 21
involved_in
ISO
(PMID:15845453)
BHF-UCL
PMID:15845453
NCBI chr10:32,093,783...32,094,482
Ensembl chr10:32,093,763...32,096,224
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CD2AP
CD2 associated protein
involved_in acts_upstream_of_or_within
IEA ISO
(PMID:14512504)
Ensembl MGI
PMID:14512504
GO_REF:0000107
NCBI chr 7:42,218,016...42,332,523
Ensembl chr 7:42,218,290...42,332,518
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CD6
CD6 molecule
involved_in
IEA
Ensembl
GO_REF:0000107
NCBI chr 2:10,739,560...10,785,548
Ensembl chr 2:10,738,471...10,785,516
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CD81
CD81 molecule
involved_in
IEA
Ensembl
GO_REF:0000107
NCBI chr 2:1,625,728...1,641,662
Ensembl chr 2:1,625,736...1,641,663
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CORO1A
coronin 1A
NOT|involved_in
ISO
(PMID:24760828)
UniProt
PMID:24760828
NCBI chr 3:18,336,813...18,342,381
Ensembl chr 3:18,336,898...18,342,396
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DLG1
discs large MAGUK scaffold protein 1
involved_in acts_upstream_of_or_within
IEA ISO
(PMID:15699074)
Ensembl MGI
PMID:15699074
GO_REF:0000107
NCBI chr13:132,819,931...133,084,880
Ensembl chr13:132,820,870...133,086,841
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DOCK2
dedicator of cytokinesis 2
involved_in acts_upstream_of_or_within
IEA ISO
(PMID:12871644)
Ensembl MGI
PMID:12871644
GO_REF:0000107
NCBI chr16:53,843,248...54,248,708
Ensembl chr16:53,843,252...54,248,638
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DOCK8
dedicator of cytokinesis 8
involved_in acts_upstream_of_or_within
IEA ISO
(PMID:22006977)
Ensembl MGI
PMID:22006977
GO_REF:0000107
NCBI chr 1:221,257,771...221,491,889
Ensembl chr 1:221,256,009...221,491,953
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EPHB1
EPH receptor B1
acts_upstream_of_or_within
ISO
PMID:17310244
MGI
PMID:17310244
RGD:10047256
NCBI chr13:75,904,678...76,351,540
Ensembl chr13:75,905,676...76,345,534
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GIT1
GIT ArfGAP 1
acts_upstream_of_or_within
ISO
PMID:17310244
MGI
PMID:17310244
RGD:10047256
NCBI chr12:45,768,172...45,783,652
Ensembl chr12:45,768,176...45,783,658
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MSN
moesin
involved_in
ISS IEA
UniProt Ensembl
GO_REF:0000024 GO_REF:0000107
NCBI chr X:51,844,197...51,967,674
Ensembl chr X:51,844,156...51,970,107
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NCK2
NCK adaptor protein 2
acts_upstream_of_or_within
ISO
PMID:17310244
MGI
PMID:17310244
RGD:10047256
NCBI chr 3:49,063,813...49,222,274
Ensembl chr 3:49,063,991...49,198,664
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PRF1
perforin 1
involved_in
IEA IBA
Ensembl GO_Central
GO_REF:0000033 GO_REF:0000107
NCBI chr14:73,515,306...73,520,256
Ensembl chr14:73,512,769...73,520,202
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HAVCR2
hepatitis A virus cellular receptor 2
involved_in
IEA
Ensembl
GO_REF:0000107
NCBI chr16:66,138,157...66,160,568
Ensembl chr16:66,139,535...66,160,538
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LGALS3
galectin 3
involved_in
ISO
(PMID:19706535)
BHF-UCL
PMID:19706535
NCBI chr 1:184,478,639...184,496,155
Ensembl chr 1:184,478,710...184,497,951
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CCR7
C-C motif chemokine receptor 7
involved_in
IEA
Ensembl
GO_REF:0000107
NCBI chr12:21,857,286...21,869,211
Ensembl chr12:21,857,286...21,872,475
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CCR7
C-C motif chemokine receptor 7
involved_in
IEA
Ensembl
GO_REF:0000107
NCBI chr12:21,857,286...21,869,211
Ensembl chr12:21,857,286...21,872,475
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NEDD9
neural precursor cell expressed, developmentally down-regulated 9
involved_in
IEA
Ensembl
GO_REF:0000107
NCBI chr 7:7,807,042...8,093,553
Ensembl chr 7:7,807,044...7,914,061
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