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ONTOLOGY REPORT - ANNOTATIONS

Term:immunological synapse formation
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Accession:GO:0001771 term browser browse the term
Definition:The formation of an area of close contact between a lymphocyte (T-, B-, or natural killer cell) and a target cell through the clustering of particular signaling and adhesion molecules and their associated membrane rafts on both the lymphocyte and target cell, which facilitates activation of the lymphocyte, transfer of membrane from the target cell to the lymphocyte, and in some situations killing of the target cell through release of secretory granules and/or death-pathway ligand-receptor interaction.
Synonyms:exact_synonym: formation of immunological synapse

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immunological synapse formation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ccl19 C-C motif chemokine ligand 19 involved_in ISO (PMID:15845453) BHF-UCL PMID:15845453 NCBI chrNW_004624736:39,088,741...39,090,745
Ensembl chrNW_004624736:39,088,921...39,090,394 		JBrowse link
G Ccl21 C-C motif chemokine ligand 21 involved_in ISO (PMID:15845453) BHF-UCL PMID:15845453 NCBI chrNW_004624736:39,121,575...39,122,708
Ensembl chrNW_004624736:39,121,466...39,122,962 		JBrowse link
G Cd2ap CD2 associated protein acts_upstream_of_or_within ISO (PMID:14512504) MGI PMID:14512504 NCBI chrNW_004624754:13,420,594...13,511,672
Ensembl chrNW_004624754:13,420,603...13,511,523 		JBrowse link
G Cd6 CD6 molecule involved_in ISO (PMID:15294938) UniProt PMID:15294938 NCBI chrNW_004624926:325,327...333,405
Ensembl chrNW_004624926:324,828...333,246 		JBrowse link
G Cd81 CD81 molecule involved_in ISO (PMID:23858057) UniProt PMID:23858057 NCBI chrNW_004624767:15,192,446...15,210,923
Ensembl chrNW_004624767:15,192,452...15,210,922 		JBrowse link
G Coro1a coronin 1A NOT|involved_in ISO (PMID:24760828) UniProt PMID:24760828 NCBI chrNW_004624782:13,106,416...13,111,394
Ensembl chrNW_004624782:13,105,153...13,111,357 		JBrowse link
G Dlg1 discs large MAGUK scaffold protein 1 acts_upstream_of_or_within ISO (PMID:15699074) MGI PMID:15699074 NCBI chrNW_004624730:62,001,547...62,223,098
Ensembl chrNW_004624730:62,002,280...62,223,319 		JBrowse link
G Dock2 dedicator of cytokinesis 2 acts_upstream_of_or_within ISO (PMID:12871644) MGI PMID:12871644 NCBI chrNW_004624733:19,882,234...20,315,211
Ensembl chrNW_004624733:19,883,027...20,315,128 		JBrowse link
G Dock8 dedicator of cytokinesis 8 acts_upstream_of_or_within ISO (PMID:22006977) MGI PMID:22006977 NCBI chrNW_004624736:4,959,482...5,195,182
Ensembl chrNW_004624736:4,959,634...5,193,928 		JBrowse link
G Ephb1 EPH receptor B1 acts_upstream_of_or_within ISO PMID:17310244 MGI PMID:17310244 RGD:10047256 NCBI chrNW_004624730:11,120,018...11,564,972
Ensembl chrNW_004624730:11,119,909...11,565,293 		JBrowse link
G Git1 GIT ArfGAP 1 acts_upstream_of_or_within ISO PMID:17310244 MGI PMID:17310244 RGD:10047256 NCBI chrNW_004624786:2,071,376...2,086,929
Ensembl chrNW_004624786:2,071,382...2,086,910 		JBrowse link
G Msn moesin involved_in ISO (PMID:27405666) UniProt PMID:27405666 NCBI chrNW_004624898:1,525,795...1,601,402
Ensembl chrNW_004624898:1,525,388...1,601,539 		JBrowse link
G Nck2 NCK adaptor protein 2 acts_upstream_of_or_within ISO PMID:17310244 MGI PMID:17310244 RGD:10047256 NCBI chrNW_004624749:9,765,308...9,884,472 JBrowse link
G Prf1 perforin 1 involved_in IEA TreeGrafter GO_REF:0000118 NCBI chrNW_004624754:4,679,451...4,681,627
Ensembl chrNW_004624754:4,679,521...4,681,627 		JBrowse link
negative regulation of immunological synapse formation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Havcr2 hepatitis A virus cellular receptor 2 involved_in ISO (PMID:24337741) UniProt PMID:24337741 NCBI chrNW_004624733:32,521,318...32,527,499 JBrowse link
G Lgals3 galectin 3 involved_in ISO (PMID:19706535) BHF-UCL PMID:19706535 NCBI chrNW_004624731:14,300,138...14,307,843
Ensembl chrNW_004624731:14,298,201...14,304,637 		JBrowse link
positive regulation of glycoprotein biosynthetic process involved in immunological synapse formation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ccr7 C-C motif chemokine receptor 7 involved_in ISO (PMID:15845453) BHF-UCL PMID:15845453 NCBI chrNW_004624795:2,777,766...2,787,664
Ensembl chrNW_004624795:2,779,627...2,788,897 		JBrowse link
positive regulation of immunological synapse formation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ccr7 C-C motif chemokine receptor 7 involved_in ISO (PMID:15845453) BHF-UCL PMID:15845453 NCBI chrNW_004624795:2,777,766...2,787,664
Ensembl chrNW_004624795:2,779,627...2,788,897 		JBrowse link
G Nedd9 neural precursor cell expressed, developmentally down-regulated 9 involved_in ISO (PMID:27359298) UniProt PMID:27359298 NCBI chrNW_004624756:14,663,114...14,850,132
Ensembl chrNW_004624756:14,737,054...14,850,708 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 17808
    cellular process 17314
      cell recognition 147
        cell-cell recognition 74
          immunological synapse formation 18
            negative regulation of immunological synapse formation 2
            positive regulation of glycoprotein biosynthetic process involved in immunological synapse formation 1
            positive regulation of immunological synapse formation 2
            regulation of immunological synapse formation + 4
Path 2
Term Annotations click to browse term
  biological_process 17808
    cellular process 17314
      cell activation 1079
        leukocyte activation 929
          lymphocyte activation 751
            immunological synapse formation 18
              negative regulation of immunological synapse formation 2
              positive regulation of glycoprotein biosynthetic process involved in immunological synapse formation 1
              positive regulation of immunological synapse formation 2
              regulation of immunological synapse formation + 4
paths to the root