ONTOLOGY REPORT - ANNOTATIONS
Term: immunological synapse formation
Accession: GO:0001771
browse the term
Definition: The formation of an area of close contact between a lymphocyte (T-, B-, or natural killer cell) and a target cell through the clustering of particular signaling and adhesion molecules and their associated membrane rafts on both the lymphocyte and target cell, which facilitates activation of the lymphocyte, transfer of membrane from the target cell to the lymphocyte, and in some situations killing of the target cell through release of secretory granules and/or death-pathway ligand-receptor interaction.
Synonyms: exact_synonym: formation of immunological synapse
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Ccl19
C-C motif chemokine ligand 19
involved_in
IDA
(PMID:15845453)
BHF-UCL
PMID:15845453
NCBI chr 4:42,754,525...42,756,558
Ensembl chr 4:42,754,525...42,756,577
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Ccl21a
C-C motif chemokine ligand 21 (serine)
involved_in
IDA
(PMID:15845453)
BHF-UCL
PMID:15845453
NCBI chr 4:42,772,860...42,773,991
Ensembl chr 4:42,772,860...42,773,993
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Cd2ap
CD2-associated protein
acts_upstream_of_or_within
IMP
(PMID:14512504)
MGI
PMID:14512504
NCBI chr17:43,059,857...43,187,593
Ensembl chr17:43,103,842...43,187,556
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Cd6
CD6 antigen
involved_in
ISO ISS
GO_Central UniProt
GO_REF:0000024 GO_REF:0000119
NCBI chr19:10,766,703...10,807,427
Ensembl chr19:10,766,705...10,807,422
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Cd81
CD81 antigen
involved_in
ISS ISO
UniProt GO_Central
GO_REF:0000024 GO_REF:0000119
NCBI chr 7:142,606,487...142,621,667
Ensembl chr 7:142,606,476...142,621,671
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Coro1a
coronin, actin binding protein 1A
NOT|involved_in
ISO
(PMID:24760828)
UniProt
PMID:24760828
NCBI chr 7:126,298,946...126,303,925
Ensembl chr 7:126,298,945...126,306,959
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Dlg1
discs large MAGUK scaffold protein 1
acts_upstream_of_or_within
IMP
(PMID:15699074)
MGI
PMID:15699074
NCBI chr16:31,482,261...31,692,174
Ensembl chr16:31,482,261...31,693,947
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Dock2
dedicator of cyto-kinesis 2
acts_upstream_of_or_within
IMP
(PMID:12871644)
MGI
PMID:12871644
NCBI chr11:34,176,815...34,674,732
Ensembl chr11:34,176,815...34,674,719
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Dock8
dedicator of cytokinesis 8
acts_upstream_of_or_within
IMP
(PMID:22006977)
MGI
PMID:22006977
NCBI chr19:24,976,753...25,179,796
Ensembl chr19:24,976,898...25,179,796
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Ephb1
Eph receptor B1
acts_upstream_of_or_within
ISO
(PMID:17310244)
MGI
PMID:17310244
NCBI chr 9:101,799,327...102,231,892
Ensembl chr 9:101,799,327...102,231,892
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Git1
GIT ArfGAP 1
acts_upstream_of_or_within
ISO
(PMID:17310244)
MGI
PMID:17310244
NCBI chr11:77,384,114...77,398,600
Ensembl chr11:77,384,388...77,398,612
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Msn
moesin
involved_in
ISS ISO
UniProt GO_Central
GO_REF:0000024 GO_REF:0000119
NCBI chr X:95,139,651...95,212,159
Ensembl chr X:95,139,648...95,212,158
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Nck2
non-catalytic region of tyrosine kinase adaptor protein 2
acts_upstream_of_or_within
ISO
(PMID:17310244)
MGI
PMID:17310244
NCBI chr 1:43,484,643...43,609,678
Ensembl chr 1:43,483,739...43,609,675
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Prf1
perforin 1 (pore forming protein)
involved_in
IBA IEA ISO
GO_Central Ensembl
GO_REF:0000033 GO_REF:0000107 GO_REF:0000119
NCBI chr10:61,133,530...61,140,463
Ensembl chr10:61,133,612...61,140,459
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Havcr2
hepatitis A virus cellular receptor 2
involved_in
IMP
(PMID:24337741)
UniProt
PMID:24337741
NCBI chr11:46,345,758...46,372,082
Ensembl chr11:46,345,762...46,372,082
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Lgals3
lectin, galactose binding, soluble 3
involved_in
IMP
(PMID:19706535)
BHF-UCL
PMID:19706535
NCBI chr14:47,611,317...47,623,624
Ensembl chr14:47,605,208...47,623,617
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Ccr7
C-C motif chemokine receptor 7
involved_in
IMP
(PMID:15845453)
BHF-UCL
PMID:15845453
NCBI chr11:99,035,025...99,045,903
Ensembl chr11:99,035,022...99,045,903
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Ccr7
C-C motif chemokine receptor 7
involved_in
IMP
(PMID:15845453)
BHF-UCL
PMID:15845453
NCBI chr11:99,035,025...99,045,903
Ensembl chr11:99,035,022...99,045,903
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Clec2i
C-type lectin domain family 2, member i
involved_in
NAS
(PMID:16143319)
BHF-UCL
PMID:16143319
NCBI chr 6:128,864,550...128,875,131
Ensembl chr 6:128,864,551...128,875,130
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Nedd9
neural precursor cell expressed, developmentally down-regulated gene 9
involved_in
IMP
(PMID:27359298)
UniProt
PMID:27359298
NCBI chr13:41,463,392...41,640,836
Ensembl chr13:41,463,057...41,640,838
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