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ONTOLOGY REPORT - ANNOTATIONS


Term:immunological synapse formation
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Accession:GO:0001771 term browser browse the term
Definition:The formation of an area of close contact between a lymphocyte (T-, B-, or natural killer cell) and a target cell through the clustering of particular signaling and adhesion molecules and their associated membrane rafts on both the lymphocyte and target cell, which facilitates activation of the lymphocyte, transfer of membrane from the target cell to the lymphocyte, and in some situations killing of the target cell through release of secretory granules and/or death-pathway ligand-receptor interaction.
Synonyms:exact_synonym: formation of immunological synapse



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immunological synapse formation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ccl19 C-C motif chemokine ligand 19 involved_in IDA (PMID:15845453) BHF-UCL PMID:15845453 NCBI chr 4:42,754,525...42,756,558
Ensembl chr 4:42,754,525...42,756,577
JBrowse link
G Ccl21a C-C motif chemokine ligand 21 (serine) involved_in IDA (PMID:15845453) BHF-UCL PMID:15845453 NCBI chr 4:42,772,860...42,773,991
Ensembl chr 4:42,772,860...42,773,993
JBrowse link
G Cd2ap CD2-associated protein acts_upstream_of_or_within IMP (PMID:14512504) MGI PMID:14512504 NCBI chr17:43,059,857...43,187,593
Ensembl chr17:43,103,842...43,187,556
JBrowse link
G Cd6 CD6 antigen involved_in ISO
ISS
GO_Central
UniProt
GO_REF:0000024 GO_REF:0000119 NCBI chr19:10,766,703...10,807,427
Ensembl chr19:10,766,705...10,807,422
JBrowse link
G Cd81 CD81 antigen involved_in ISS
ISO
UniProt
GO_Central
GO_REF:0000024 GO_REF:0000119 NCBI chr 7:142,606,487...142,621,667
Ensembl chr 7:142,606,476...142,621,671
JBrowse link
G Coro1a coronin, actin binding protein 1A NOT|involved_in ISO (PMID:24760828) UniProt PMID:24760828 NCBI chr 7:126,298,946...126,303,925
Ensembl chr 7:126,298,945...126,306,959
JBrowse link
G Dlg1 discs large MAGUK scaffold protein 1 acts_upstream_of_or_within IMP (PMID:15699074) MGI PMID:15699074 NCBI chr16:31,482,261...31,692,174
Ensembl chr16:31,482,261...31,693,947
JBrowse link
G Dock2 dedicator of cyto-kinesis 2 acts_upstream_of_or_within IMP (PMID:12871644) MGI PMID:12871644 NCBI chr11:34,176,815...34,674,732
Ensembl chr11:34,176,815...34,674,719
JBrowse link
G Dock8 dedicator of cytokinesis 8 acts_upstream_of_or_within IMP (PMID:22006977) MGI PMID:22006977 NCBI chr19:24,976,753...25,179,796
Ensembl chr19:24,976,898...25,179,796
JBrowse link
G Ephb1 Eph receptor B1 acts_upstream_of_or_within ISO (PMID:17310244) MGI PMID:17310244 NCBI chr 9:101,799,327...102,231,892
Ensembl chr 9:101,799,327...102,231,892
JBrowse link
G Git1 GIT ArfGAP 1 acts_upstream_of_or_within ISO (PMID:17310244) MGI PMID:17310244 NCBI chr11:77,384,114...77,398,600
Ensembl chr11:77,384,388...77,398,612
JBrowse link
G Msn moesin involved_in ISS
ISO
UniProt
GO_Central
GO_REF:0000024 GO_REF:0000119 NCBI chr  X:95,139,651...95,212,159
Ensembl chr  X:95,139,648...95,212,158
JBrowse link
G Nck2 non-catalytic region of tyrosine kinase adaptor protein 2 acts_upstream_of_or_within ISO (PMID:17310244) MGI PMID:17310244 NCBI chr 1:43,484,643...43,609,678
Ensembl chr 1:43,483,739...43,609,675
JBrowse link
G Prf1 perforin 1 (pore forming protein) involved_in IBA
IEA
ISO
GO_Central
Ensembl
GO_REF:0000033 GO_REF:0000107 GO_REF:0000119 NCBI chr10:61,133,530...61,140,463
Ensembl chr10:61,133,612...61,140,459
JBrowse link
negative regulation of immunological synapse formation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Havcr2 hepatitis A virus cellular receptor 2 involved_in IMP (PMID:24337741) UniProt PMID:24337741 NCBI chr11:46,345,758...46,372,082
Ensembl chr11:46,345,762...46,372,082
JBrowse link
G Lgals3 lectin, galactose binding, soluble 3 involved_in IMP (PMID:19706535) BHF-UCL PMID:19706535 NCBI chr14:47,611,317...47,623,624
Ensembl chr14:47,605,208...47,623,617
JBrowse link
positive regulation of glycoprotein biosynthetic process involved in immunological synapse formation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ccr7 C-C motif chemokine receptor 7 involved_in IMP (PMID:15845453) BHF-UCL PMID:15845453 NCBI chr11:99,035,025...99,045,903
Ensembl chr11:99,035,022...99,045,903
JBrowse link
positive regulation of immunological synapse formation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ccr7 C-C motif chemokine receptor 7 involved_in IMP (PMID:15845453) BHF-UCL PMID:15845453 NCBI chr11:99,035,025...99,045,903
Ensembl chr11:99,035,022...99,045,903
JBrowse link
G Clec2i C-type lectin domain family 2, member i involved_in NAS (PMID:16143319) BHF-UCL PMID:16143319 NCBI chr 6:128,864,550...128,875,131
Ensembl chr 6:128,864,551...128,875,130
JBrowse link
G Nedd9 neural precursor cell expressed, developmentally down-regulated gene 9 involved_in IMP (PMID:27359298) UniProt PMID:27359298 NCBI chr13:41,463,392...41,640,836
Ensembl chr13:41,463,057...41,640,838
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 28633
    cellular process 18391
      cell recognition 176
        cell-cell recognition 85
          immunological synapse formation 19
            negative regulation of immunological synapse formation 2
            positive regulation of glycoprotein biosynthetic process involved in immunological synapse formation 1
            positive regulation of immunological synapse formation 3
            regulation of immunological synapse formation + 5
Path 2
Term Annotations click to browse term
  biological_process 28633
    cellular process 18391
      cell activation 1306
        leukocyte activation 1148
          lymphocyte activation 944
            immunological synapse formation 19
              negative regulation of immunological synapse formation 2
              positive regulation of glycoprotein biosynthetic process involved in immunological synapse formation 1
              positive regulation of immunological synapse formation 3
              regulation of immunological synapse formation + 5
paths to the root