ONTOLOGY REPORT - ANNOTATIONS
Term: immunological synapse formation
Accession: GO:0001771
browse the term
Definition: The formation of an area of close contact between a lymphocyte (T-, B-, or natural killer cell) and a target cell through the clustering of particular signaling and adhesion molecules and their associated membrane rafts on both the lymphocyte and target cell, which facilitates activation of the lymphocyte, transfer of membrane from the target cell to the lymphocyte, and in some situations killing of the target cell through release of secretory granules and/or death-pathway ligand-receptor interaction.
Synonyms: exact_synonym: formation of immunological synapse
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CCL19
C-C motif chemokine ligand 19
involved_in
ISS
BHF-UCL
GO_REF:0000024
NCBI chr 9:34,689,570...34,691,276
Ensembl chr 9:34,689,570...34,691,276
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CCL21
C-C motif chemokine ligand 21
involved_in
ISS
BHF-UCL
GO_REF:0000024
NCBI chr 9:34,709,005...34,710,136
Ensembl chr 9:34,709,005...34,710,136
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CD2AP
CD2 associated protein
involved_in acts_upstream_of_or_within
IEA ISO
(PMID:14512504)
Ensembl MGI
PMID:14512504
GO_REF:0000107
NCBI chr 6:47,477,789...47,627,263
Ensembl chr 6:47,477,789...47,627,263
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CD6
CD6 molecule
involved_in
IMP
(PMID:15294938)
UniProt
PMID:15294938
NCBI chr11:60,971,680...61,020,377
Ensembl chr11:60,971,680...61,020,377
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CD81
CD81 molecule
involved_in
IMP
(PMID:23858057)
UniProt
PMID:23858057
NCBI chr11:2,376,180...2,397,397
Ensembl chr11:2,376,177...2,397,802
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CORO1A
coronin 1A
NOT|involved_in
IMP
(PMID:24760828)
UniProt
PMID:24760828
NCBI chr16:30,183,602...30,189,076
Ensembl chr16:30,182,827...30,189,076
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DLG1
discs large MAGUK scaffold protein 1
involved_in acts_upstream_of_or_within
IEA ISO
(PMID:15699074)
Ensembl MGI
PMID:15699074
GO_REF:0000107
NCBI chr 3:197,042,560...197,299,321
Ensembl chr 3:197,042,560...197,299,330
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DOCK2
dedicator of cytokinesis 2
involved_in acts_upstream_of_or_within
IEA ISO
(PMID:12871644)
Ensembl MGI
PMID:12871644
GO_REF:0000107
NCBI chr 5:169,637,275...170,083,382
Ensembl chr 5:169,637,268...170,083,382
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DOCK8
dedicator of cytokinesis 8
involved_in acts_upstream_of_or_within
IEA ISO
(PMID:22006977)
Ensembl MGI
PMID:22006977
GO_REF:0000107
NCBI chr 9:211,257...465,255
Ensembl chr 9:214,854...465,259
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EPHB1
EPH receptor B1
acts_upstream_of_or_within involved_in
ISO IEA
PMID:17310244
MGI Ensembl
PMID:17310244
GO_REF:0000107 RGD:10047256
NCBI chr 3:134,795,260...135,260,467
Ensembl chr 3:134,795,260...135,260,467
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GIT1
GIT ArfGAP 1
acts_upstream_of_or_within
ISO
PMID:17310244
MGI
PMID:17310244
RGD:10047256
NCBI chr17:29,573,475...29,589,648
Ensembl chr17:29,573,475...29,594,054
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MSN
moesin
involved_in
IDA
(PMID:27405666)
UniProt
PMID:27405666
NCBI chr X:65,588,377...65,741,931
Ensembl chr X:65,588,377...65,741,931
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NCK2
NCK adaptor protein 2
acts_upstream_of_or_within involved_in
ISO IEA
PMID:17310244
MGI Ensembl
PMID:17310244
GO_REF:0000107 RGD:10047256
NCBI chr 2:105,744,453...105,894,272
Ensembl chr 2:105,744,912...105,894,274
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PRF1
perforin 1
involved_in
IDA IBA
(PMID:21438968)
UniProt GO_Central
PMID:21438968
GO_REF:0000033
NCBI chr10:70,597,348...70,602,741
Ensembl chr10:70,597,348...70,602,759
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HAVCR2
hepatitis A virus cellular receptor 2
involved_in
IEA
Ensembl
GO_REF:0000107
NCBI chr 5:157,085,832...157,109,044
Ensembl chr 5:157,085,422...157,142,869
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LGALS3
galectin 3
involved_in
ISS
(PMID:19706535)
BHF-UCL
PMID:19706535
NCBI chr14:55,129,252...55,145,430
Ensembl chr14:55,124,110...55,145,423
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CCR7
C-C motif chemokine receptor 7
involved_in
ISS IEA
BHF-UCL Ensembl
GO_REF:0000024 GO_REF:0000107
NCBI chr17:40,553,769...40,565,472
Ensembl chr17:40,551,081...40,565,472
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CCR7
C-C motif chemokine receptor 7
involved_in
IEA ISS
Ensembl BHF-UCL
GO_REF:0000024 GO_REF:0000107
NCBI chr17:40,553,769...40,565,472
Ensembl chr17:40,551,081...40,565,472
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NEDD9
neural precursor cell expressed, developmentally down-regulated 9
involved_in
ISS IEA
UniProt Ensembl
GO_REF:0000024 GO_REF:0000107
NCBI chr 6:11,183,298...11,382,348
Ensembl chr 6:11,183,298...11,382,348
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