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ONTOLOGY REPORT - ANNOTATIONS


Term:immunological synapse formation
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Accession:GO:0001771 term browser browse the term
Definition:The formation of an area of close contact between a lymphocyte (T-, B-, or natural killer cell) and a target cell through the clustering of particular signaling and adhesion molecules and their associated membrane rafts on both the lymphocyte and target cell, which facilitates activation of the lymphocyte, transfer of membrane from the target cell to the lymphocyte, and in some situations killing of the target cell through release of secretory granules and/or death-pathway ligand-receptor interaction.
Synonyms:exact_synonym: formation of immunological synapse



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immunological synapse formation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G CCL19 C-C motif chemokine ligand 19 involved_in ISS BHF-UCL GO_REF:0000024 NCBI chr 9:34,689,570...34,691,276
Ensembl chr 9:34,689,570...34,691,276
JBrowse link
G CCL21 C-C motif chemokine ligand 21 involved_in ISS BHF-UCL GO_REF:0000024 NCBI chr 9:34,709,005...34,710,136
Ensembl chr 9:34,709,005...34,710,136
JBrowse link
G CD2AP CD2 associated protein involved_in
acts_upstream_of_or_within
IEA
ISO
(PMID:14512504) Ensembl
MGI
PMID:14512504 GO_REF:0000107 NCBI chr 6:47,477,789...47,627,263
Ensembl chr 6:47,477,789...47,627,263
JBrowse link
G CD6 CD6 molecule involved_in IMP (PMID:15294938) UniProt PMID:15294938 NCBI chr11:60,971,680...61,020,377
Ensembl chr11:60,971,680...61,020,377
JBrowse link
G CD81 CD81 molecule involved_in IMP (PMID:23858057) UniProt PMID:23858057 NCBI chr11:2,376,180...2,397,397
Ensembl chr11:2,376,177...2,397,802
JBrowse link
G CORO1A coronin 1A NOT|involved_in IMP (PMID:24760828) UniProt PMID:24760828 NCBI chr16:30,183,602...30,189,076
Ensembl chr16:30,182,827...30,189,076
JBrowse link
G DLG1 discs large MAGUK scaffold protein 1 involved_in
acts_upstream_of_or_within
IEA
ISO
(PMID:15699074) Ensembl
MGI
PMID:15699074 GO_REF:0000107 NCBI chr 3:197,042,560...197,299,321
Ensembl chr 3:197,042,560...197,299,330
JBrowse link
G DOCK2 dedicator of cytokinesis 2 involved_in
acts_upstream_of_or_within
IEA
ISO
(PMID:12871644) Ensembl
MGI
PMID:12871644 GO_REF:0000107 NCBI chr 5:169,637,275...170,083,382
Ensembl chr 5:169,637,268...170,083,382
JBrowse link
G DOCK8 dedicator of cytokinesis 8 involved_in
acts_upstream_of_or_within
IEA
ISO
(PMID:22006977) Ensembl
MGI
PMID:22006977 GO_REF:0000107 NCBI chr 9:211,257...465,255
Ensembl chr 9:214,854...465,259
JBrowse link
G EPHB1 EPH receptor B1 acts_upstream_of_or_within
involved_in
ISO
IEA
PMID:17310244 MGI
Ensembl
PMID:17310244 GO_REF:0000107 RGD:10047256 NCBI chr 3:134,795,260...135,260,467
Ensembl chr 3:134,795,260...135,260,467
JBrowse link
G GIT1 GIT ArfGAP 1 acts_upstream_of_or_within ISO PMID:17310244 MGI PMID:17310244 RGD:10047256 NCBI chr17:29,573,475...29,589,648
Ensembl chr17:29,573,475...29,594,054
JBrowse link
G MSN moesin involved_in IDA (PMID:27405666) UniProt PMID:27405666 NCBI chr  X:65,588,377...65,741,931
Ensembl chr  X:65,588,377...65,741,931
JBrowse link
G NCK2 NCK adaptor protein 2 acts_upstream_of_or_within
involved_in
ISO
IEA
PMID:17310244 MGI
Ensembl
PMID:17310244 GO_REF:0000107 RGD:10047256 NCBI chr 2:105,744,453...105,894,272
Ensembl chr 2:105,744,912...105,894,274
JBrowse link
G PRF1 perforin 1 involved_in IDA
IBA
(PMID:21438968) UniProt
GO_Central
PMID:21438968 GO_REF:0000033 NCBI chr10:70,597,348...70,602,741
Ensembl chr10:70,597,348...70,602,759
JBrowse link
negative regulation of immunological synapse formation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G HAVCR2 hepatitis A virus cellular receptor 2 involved_in IEA Ensembl GO_REF:0000107 NCBI chr 5:157,085,832...157,109,044
Ensembl chr 5:157,085,422...157,142,869
JBrowse link
G LGALS3 galectin 3 involved_in ISS (PMID:19706535) BHF-UCL PMID:19706535 NCBI chr14:55,129,252...55,145,430
Ensembl chr14:55,124,110...55,145,423
JBrowse link
positive regulation of glycoprotein biosynthetic process involved in immunological synapse formation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G CCR7 C-C motif chemokine receptor 7 involved_in ISS
IEA
BHF-UCL
Ensembl
GO_REF:0000024 GO_REF:0000107 NCBI chr17:40,553,769...40,565,472
Ensembl chr17:40,551,081...40,565,472
JBrowse link
positive regulation of immunological synapse formation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G CCR7 C-C motif chemokine receptor 7 involved_in IEA
ISS
Ensembl
BHF-UCL
GO_REF:0000024 GO_REF:0000107 NCBI chr17:40,553,769...40,565,472
Ensembl chr17:40,551,081...40,565,472
JBrowse link
G NEDD9 neural precursor cell expressed, developmentally down-regulated 9 involved_in ISS
IEA
UniProt
Ensembl
GO_REF:0000024 GO_REF:0000107 NCBI chr 6:11,183,298...11,382,348
Ensembl chr 6:11,183,298...11,382,348
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 20484
    cellular process 19726
      cell recognition 187
        cell-cell recognition 89
          immunological synapse formation 18
            negative regulation of immunological synapse formation 2
            positive regulation of glycoprotein biosynthetic process involved in immunological synapse formation 1
            positive regulation of immunological synapse formation 2
            regulation of immunological synapse formation + 4
Path 2
Term Annotations click to browse term
  biological_process 20484
    cellular process 19726
      cell activation 1325
        leukocyte activation 1149
          lymphocyte activation 945
            immunological synapse formation 18
              negative regulation of immunological synapse formation 2
              positive regulation of glycoprotein biosynthetic process involved in immunological synapse formation 1
              positive regulation of immunological synapse formation 2
              regulation of immunological synapse formation + 4
paths to the root