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ONTOLOGY REPORT - ANNOTATIONS


Term:immunological synapse formation
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Accession:GO:0001771 term browser browse the term
Definition:The formation of an area of close contact between a lymphocyte (T-, B-, or natural killer cell) and a target cell through the clustering of particular signaling and adhesion molecules and their associated membrane rafts on both the lymphocyte and target cell, which facilitates activation of the lymphocyte, transfer of membrane from the target cell to the lymphocyte, and in some situations killing of the target cell through release of secretory granules and/or death-pathway ligand-receptor interaction.
Synonyms:exact_synonym: formation of immunological synapse


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immunological synapse formation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G CCL19 C-C motif chemokine ligand 19 involved_in ISO (PMID:15845453) BHF-UCL PMID:15845453 NCBI chr12:45,928,212...45,930,897
Ensembl chr12:45,929,071...45,930,904
JBrowse link
G CCL21 C-C motif chemokine ligand 21 involved_in ISO (PMID:15845453) BHF-UCL PMID:15845453 NCBI chr12:45,787,118...45,788,506
Ensembl chr12:45,787,356...45,908,711
JBrowse link
G CD2AP CD2 associated protein involved_in
acts_upstream_of_or_within
IEA
ISO
(PMID:14512504) Ensembl
MGI
PMID:14512504 GO_REF:0000107 NCBI chr17:24,664,245...24,815,786
Ensembl chr17:24,663,872...24,815,829
JBrowse link
G CD6 CD6 molecule involved_in IEA Ensembl GO_REF:0000107 NCBI chr 1:12,827,238...12,878,304
Ensembl chr 1:12,828,285...12,877,704
JBrowse link
G CD81 CD81 molecule involved_in IEA Ensembl GO_REF:0000107 NCBI chr 1:2,190,896...2,211,838
Ensembl chr 1:2,190,845...2,211,389
JBrowse link
G CORO1A coronin 1A NOT|involved_in ISO (PMID:24760828) UniProt PMID:24760828 NCBI chr 5:26,482,269...26,488,537
Ensembl chr 5:26,480,753...26,487,929
JBrowse link
G DLG1 discs large MAGUK scaffold protein 1 acts_upstream_of_or_within ISO (PMID:15699074) MGI PMID:15699074 NCBI chr15:89,937,900...90,214,976
Ensembl chr15:90,055,964...90,215,652
JBrowse link
G DOCK2 dedicator of cytokinesis 2 involved_in
acts_upstream_of_or_within
IEA
ISO
(PMID:12871644) Ensembl
MGI
PMID:12871644 GO_REF:0000107 NCBI chr23:71,866,196...72,299,066
Ensembl chr23:71,866,251...72,299,056
JBrowse link
G DOCK8 dedicator of cytokinesis 8 involved_in
acts_upstream_of_or_within
IEA
ISO
(PMID:22006977) Ensembl
MGI
PMID:22006977 GO_REF:0000107 NCBI chr12:79,060,579...79,298,145
Ensembl chr12:79,060,425...79,298,164
JBrowse link
G EPHB1 EPH receptor B1 acts_upstream_of_or_within ISO PMID:17310244 MGI PMID:17310244 RGD:10047256 NCBI chr15:55,144,178...55,592,252
Ensembl chr15:55,143,630...55,589,862
JBrowse link
G GIT1 GIT ArfGAP 1 acts_upstream_of_or_within ISO PMID:17310244 MGI PMID:17310244 RGD:10047256 NCBI chr16:23,313,629...23,329,665
Ensembl chr16:23,315,439...23,329,469
JBrowse link
G MSN moesin involved_in IEA Ensembl GO_REF:0000107 NCBI chr  X:55,660,262...55,734,605
Ensembl chr  X:55,660,234...55,735,191
JBrowse link
G NCK2 NCK adaptor protein 2 acts_upstream_of_or_within ISO PMID:17310244 MGI PMID:17310244 RGD:10047256 NCBI chr14:9,412,677...9,515,565
Ensembl chr14:9,437,301...9,515,561
JBrowse link
G PRF1 perforin 1 involved_in IEA TreeGrafter
Ensembl
GO_REF:0000107 GO_REF:0000118 NCBI chr 9:60,692,544...60,698,000
Ensembl chr 9:60,692,600...60,698,465
JBrowse link
negative regulation of immunological synapse formation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G HAVCR2 hepatitis A virus cellular receptor 2 involved_in IEA Ensembl GO_REF:0000107 NCBI chr23:59,479,794...59,501,532
Ensembl chr23:59,475,826...59,500,836
JBrowse link
G LGALS3 galectin 3 involved_in ISO (PMID:19706535) BHF-UCL PMID:19706535 NCBI chr24:32,311,343...32,328,335
Ensembl chr24:32,311,271...32,328,339
JBrowse link
positive regulation of glycoprotein biosynthetic process involved in immunological synapse formation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G CCR7 C-C motif chemokine receptor 7 involved_in IEA Ensembl GO_REF:0000107 NCBI chr16:65,620,632...65,632,394
Ensembl chr16:65,620,665...65,632,984
JBrowse link
positive regulation of immunological synapse formation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G CCR7 C-C motif chemokine receptor 7 involved_in IEA Ensembl GO_REF:0000107 NCBI chr16:65,620,632...65,632,394
Ensembl chr16:65,620,665...65,632,984
JBrowse link
G NEDD9 neural precursor cell expressed, developmentally down-regulated 9 involved_in IEA Ensembl GO_REF:0000107 NCBI chr17:60,759,411...60,959,558
Ensembl chr17:60,911,264...60,959,603
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 19803
    cellular process 19325
      cell recognition 162
        cell-cell recognition 83
          immunological synapse formation 18
            negative regulation of immunological synapse formation 2
            positive regulation of glycoprotein biosynthetic process involved in immunological synapse formation 1
            positive regulation of immunological synapse formation 2
            regulation of immunological synapse formation + 4
Path 2
Term Annotations click to browse term
  biological_process 19803
    cellular process 19325
      cell activation 1213
        leukocyte activation 1031
          lymphocyte activation 845
            immunological synapse formation 18
              negative regulation of immunological synapse formation 2
              positive regulation of glycoprotein biosynthetic process involved in immunological synapse formation 1
              positive regulation of immunological synapse formation 2
              regulation of immunological synapse formation + 4
paths to the root