ONTOLOGY REPORT - ANNOTATIONS
Term: immunological synapse formation
Accession: GO:0001771
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Definition: The formation of an area of close contact between a lymphocyte (T-, B-, or natural killer cell) and a target cell through the clustering of particular signaling and adhesion molecules and their associated membrane rafts on both the lymphocyte and target cell, which facilitates activation of the lymphocyte, transfer of membrane from the target cell to the lymphocyte, and in some situations killing of the target cell through release of secretory granules and/or death-pathway ligand-receptor interaction.
Synonyms: exact_synonym: formation of immunological synapse
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CCL19
C-C motif chemokine ligand 19
involved_in
ISO
(PMID:15845453)
BHF-UCL
PMID:15845453
NCBI chr12:45,928,212...45,930,897
Ensembl chr12:45,929,071...45,930,904
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CCL21
C-C motif chemokine ligand 21
involved_in
ISO
(PMID:15845453)
BHF-UCL
PMID:15845453
NCBI chr12:45,787,118...45,788,506
Ensembl chr12:45,787,356...45,908,711
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CD2AP
CD2 associated protein
involved_in acts_upstream_of_or_within
IEA ISO
(PMID:14512504)
Ensembl MGI
PMID:14512504
GO_REF:0000107
NCBI chr17:24,664,245...24,815,786
Ensembl chr17:24,663,872...24,815,829
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CD6
CD6 molecule
involved_in
IEA
Ensembl
GO_REF:0000107
NCBI chr 1:12,827,238...12,878,304
Ensembl chr 1:12,828,285...12,877,704
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CD81
CD81 molecule
involved_in
IEA
Ensembl
GO_REF:0000107
NCBI chr 1:2,190,896...2,211,838
Ensembl chr 1:2,190,845...2,211,389
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CORO1A
coronin 1A
NOT|involved_in
ISO
(PMID:24760828)
UniProt
PMID:24760828
NCBI chr 5:26,482,269...26,488,537
Ensembl chr 5:26,480,753...26,487,929
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DLG1
discs large MAGUK scaffold protein 1
acts_upstream_of_or_within
ISO
(PMID:15699074)
MGI
PMID:15699074
NCBI chr15:89,937,900...90,214,976
Ensembl chr15:90,055,964...90,215,652
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DOCK2
dedicator of cytokinesis 2
involved_in acts_upstream_of_or_within
IEA ISO
(PMID:12871644)
Ensembl MGI
PMID:12871644
GO_REF:0000107
NCBI chr23:71,866,196...72,299,066
Ensembl chr23:71,866,251...72,299,056
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DOCK8
dedicator of cytokinesis 8
involved_in acts_upstream_of_or_within
IEA ISO
(PMID:22006977)
Ensembl MGI
PMID:22006977
GO_REF:0000107
NCBI chr12:79,060,579...79,298,145
Ensembl chr12:79,060,425...79,298,164
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EPHB1
EPH receptor B1
acts_upstream_of_or_within
ISO
PMID:17310244
MGI
PMID:17310244
RGD:10047256
NCBI chr15:55,144,178...55,592,252
Ensembl chr15:55,143,630...55,589,862
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GIT1
GIT ArfGAP 1
acts_upstream_of_or_within
ISO
PMID:17310244
MGI
PMID:17310244
RGD:10047256
NCBI chr16:23,313,629...23,329,665
Ensembl chr16:23,315,439...23,329,469
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MSN
moesin
involved_in
IEA
Ensembl
GO_REF:0000107
NCBI chr X:55,660,262...55,734,605
Ensembl chr X:55,660,234...55,735,191
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NCK2
NCK adaptor protein 2
acts_upstream_of_or_within
ISO
PMID:17310244
MGI
PMID:17310244
RGD:10047256
NCBI chr14:9,412,677...9,515,565
Ensembl chr14:9,437,301...9,515,561
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PRF1
perforin 1
involved_in
IEA
TreeGrafter Ensembl
GO_REF:0000107 GO_REF:0000118
NCBI chr 9:60,692,544...60,698,000
Ensembl chr 9:60,692,600...60,698,465
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HAVCR2
hepatitis A virus cellular receptor 2
involved_in
IEA
Ensembl
GO_REF:0000107
NCBI chr23:59,479,794...59,501,532
Ensembl chr23:59,475,826...59,500,836
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LGALS3
galectin 3
involved_in
ISO
(PMID:19706535)
BHF-UCL
PMID:19706535
NCBI chr24:32,311,343...32,328,335
Ensembl chr24:32,311,271...32,328,339
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CCR7
C-C motif chemokine receptor 7
involved_in
IEA
Ensembl
GO_REF:0000107
NCBI chr16:65,620,632...65,632,394
Ensembl chr16:65,620,665...65,632,984
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CCR7
C-C motif chemokine receptor 7
involved_in
IEA
Ensembl
GO_REF:0000107
NCBI chr16:65,620,632...65,632,394
Ensembl chr16:65,620,665...65,632,984
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NEDD9
neural precursor cell expressed, developmentally down-regulated 9
involved_in
IEA
Ensembl
GO_REF:0000107
NCBI chr17:60,759,411...60,959,558
Ensembl chr17:60,911,264...60,959,603
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