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ONTOLOGY REPORT - ANNOTATIONS


Term:immunological synapse formation
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Accession:GO:0001771 term browser browse the term
Definition:The formation of an area of close contact between a lymphocyte (T-, B-, or natural killer cell) and a target cell through the clustering of particular signaling and adhesion molecules and their associated membrane rafts on both the lymphocyte and target cell, which facilitates activation of the lymphocyte, transfer of membrane from the target cell to the lymphocyte, and in some situations killing of the target cell through release of secretory granules and/or death-pathway ligand-receptor interaction.
Synonyms:exact_synonym: formation of immunological synapse



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immunological synapse formation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G CCL19 C-C motif chemokine ligand 19 involved_in ISO (PMID:15845453) BHF-UCL PMID:15845453 NCBI chr11:51,357,706...51,359,207
Ensembl chr11:51,340,530...51,359,365
JBrowse link
G CCL21 C-C motif chemokine ligand 21 involved_in ISO (PMID:15845453) BHF-UCL PMID:15845453 NCBI chr11:51,375,107...51,375,790 JBrowse link
G CD2AP CD2 associated protein involved_in
acts_upstream_of_or_within
IEA
ISO
(PMID:14512504) Ensembl
MGI
PMID:14512504 GO_REF:0000107 NCBI chr12:15,538,215...15,683,619
Ensembl chr12:15,538,356...15,681,011
JBrowse link
G CD6 CD6 molecule involved_in IEA Ensembl GO_REF:0000107 NCBI chr18:55,296,116...55,336,014
Ensembl chr18:55,296,986...55,335,880
JBrowse link
G CD81 CD81 molecule involved_in ISO (PMID:23858057) UniProt PMID:23858057 NCBI chr18:46,466,484...46,474,236
Ensembl chr18:46,466,499...46,473,868
JBrowse link
G CORO1A coronin 1A NOT|involved_in ISO (PMID:24760828) UniProt PMID:24760828 NCBI chr 6:18,161,850...18,167,915
Ensembl chr 6:18,160,601...18,167,818
JBrowse link
G DLG1 discs large MAGUK scaffold protein 1 involved_in
acts_upstream_of_or_within
IEA
ISO
(PMID:15699074) Ensembl
MGI
PMID:15699074 GO_REF:0000107 NCBI chr33:30,016,323...30,253,180
Ensembl chr33:30,016,600...30,253,547
JBrowse link
G DOCK2 dedicator of cytokinesis 2 involved_in
acts_upstream_of_or_within
IEA
ISO
(PMID:12871644) Ensembl
MGI
PMID:12871644 GO_REF:0000107 NCBI chr 4:41,779,950...42,177,957
Ensembl chr 4:41,780,436...42,235,177
JBrowse link
G DOCK8 dedicator of cytokinesis 8 involved_in
acts_upstream_of_or_within
IEA
ISO
(PMID:22006977) Ensembl
MGI
PMID:22006977 GO_REF:0000107 NCBI chr 1:89,152,456...89,379,203
Ensembl chr 1:89,150,856...89,378,013
JBrowse link
G EPHB1 EPH receptor B1 acts_upstream_of_or_within ISO PMID:17310244 MGI PMID:17310244 RGD:10047256 NCBI chr23:31,485,701...31,918,754
Ensembl chr23:31,485,534...31,917,393
JBrowse link
G GIT1 GIT ArfGAP 1 acts_upstream_of_or_within ISO PMID:17310244 MGI PMID:17310244 RGD:10047256 NCBI chr 9:43,676,707...43,686,566
Ensembl chr 9:43,677,899...43,693,177
JBrowse link
G MSN moesin involved_in ISO (PMID:27405666) UniProt PMID:27405666 NCBI chr  X:50,708,913...50,775,404
Ensembl chr  X:50,708,704...50,773,762
JBrowse link
G NCK2 NCK adaptor protein 2 acts_upstream_of_or_within ISO PMID:17310244 MGI PMID:17310244 RGD:10047256 NCBI chr10:37,584,351...37,734,388
Ensembl chr10:37,585,565...37,732,994
JBrowse link
G PRF1 perforin 1 involved_in IEA
IBA
Ensembl
GO_Central
GO_REF:0000033 GO_REF:0000107 NCBI chr 4:21,497,865...21,502,429
Ensembl chr 4:21,498,249...21,500,864
JBrowse link
negative regulation of immunological synapse formation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G HAVCR2 hepatitis A virus cellular receptor 2 involved_in IEA Ensembl GO_REF:0000107 NCBI chr 4:53,018,990...53,032,035
Ensembl chr 4:53,012,234...53,033,393
JBrowse link
G LGALS3 galectin 3 involved_in ISO (PMID:19706535) BHF-UCL PMID:19706535 NCBI chr 8:30,977,438...30,994,711
Ensembl chr 8:30,983,633...30,994,705
JBrowse link
positive regulation of glycoprotein biosynthetic process involved in immunological synapse formation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G CCR7 C-C motif chemokine receptor 7 involved_in IEA Ensembl GO_REF:0000107 NCBI chr 9:22,077,976...22,092,818
Ensembl chr 9:22,068,775...22,090,656
JBrowse link
positive regulation of immunological synapse formation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G CCR7 C-C motif chemokine receptor 7 involved_in IEA Ensembl GO_REF:0000107 NCBI chr 9:22,077,976...22,092,818
Ensembl chr 9:22,068,775...22,090,656
JBrowse link
G NEDD9 neural precursor cell expressed, developmentally down-regulated 9 involved_in IEA Ensembl GO_REF:0000107 NCBI chr35:10,852,334...11,033,656
Ensembl chr35:10,854,295...10,964,650
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 22100
    cellular process 21630
      cell recognition 163
        cell-cell recognition 84
          immunological synapse formation 18
            negative regulation of immunological synapse formation 2
            positive regulation of glycoprotein biosynthetic process involved in immunological synapse formation 1
            positive regulation of immunological synapse formation 2
            regulation of immunological synapse formation + 4
Path 2
Term Annotations click to browse term
  biological_process 22100
    cellular process 21630
      cell activation 1192
        leukocyte activation 1044
          lymphocyte activation 850
            immunological synapse formation 18
              negative regulation of immunological synapse formation 2
              positive regulation of glycoprotein biosynthetic process involved in immunological synapse formation 1
              positive regulation of immunological synapse formation 2
              regulation of immunological synapse formation + 4
paths to the root