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ONTOLOGY REPORT - ANNOTATIONS

Term:immunological synapse formation
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Accession:GO:0001771 term browser browse the term
Definition:The formation of an area of close contact between a lymphocyte (T-, B-, or natural killer cell) and a target cell through the clustering of particular signaling and adhesion molecules and their associated membrane rafts on both the lymphocyte and target cell, which facilitates activation of the lymphocyte, transfer of membrane from the target cell to the lymphocyte, and in some situations killing of the target cell through release of secretory granules and/or death-pathway ligand-receptor interaction.
Synonyms:exact_synonym: formation of immunological synapse

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immunological synapse formation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ccl19 C-C motif chemokine ligand 19 involved_in ISO (PMID:15845453) BHF-UCL PMID:15845453 NCBI chrNW_004955472:1,444,598...1,446,488
Ensembl chrNW_004955472:1,444,316...1,446,490 		JBrowse link
G Ccl21 C-C motif chemokine ligand 21 involved_in ISO (PMID:15845453) BHF-UCL PMID:15845453 NCBI chrNW_004955472:1,427,660...1,428,771
Ensembl chrNW_004955472:1,427,710...1,429,102 		JBrowse link
G Cd2ap CD2 associated protein acts_upstream_of_or_within ISO (PMID:14512504) MGI PMID:14512504 NCBI chrNW_004955437:12,005,399...12,087,014
Ensembl chrNW_004955437:11,983,311...12,091,100 		JBrowse link
G Cd6 CD6 molecule involved_in ISO (PMID:15294938) UniProt PMID:15294938 NCBI chrNW_004955511:5,592,176...5,617,421 JBrowse link
G Cd81 CD81 molecule involved_in ISO (PMID:23858057) UniProt PMID:23858057 NCBI chrNW_004955422:14,155,682...14,175,181
Ensembl chrNW_004955422:14,155,682...14,175,181 		JBrowse link
G Coro1a coronin 1A NOT|involved_in ISO (PMID:24760828) UniProt PMID:24760828 NCBI chrNW_004955493:6,815,148...6,820,295
Ensembl chrNW_004955493:6,811,430...6,826,485 		JBrowse link
G Dlg1 discs large MAGUK scaffold protein 1 acts_upstream_of_or_within ISO (PMID:15699074) MGI PMID:15699074 NCBI chrNW_004955420:13,068,289...13,273,805
Ensembl chrNW_004955420:13,068,289...13,273,805 		JBrowse link
G Dock2 dedicator of cytokinesis 2 acts_upstream_of_or_within ISO (PMID:12871644) MGI PMID:12871644 NCBI chrNW_004955408:22,630,375...23,059,832
Ensembl chrNW_004955408:22,630,364...23,059,899 		JBrowse link
G Dock8 dedicator of cytokinesis 8 acts_upstream_of_or_within ISO (PMID:22006977) MGI PMID:22006977 NCBI chrNW_004955434:4,849,147...5,050,545
Ensembl chrNW_004955434:4,867,016...5,049,118 		JBrowse link
G Ephb1 EPH receptor B1 acts_upstream_of_or_within ISO PMID:17310244 MGI PMID:17310244 RGD:10047256 NCBI chrNW_004955501:3,424,112...3,821,727
Ensembl chrNW_004955501:3,423,977...3,821,890 		JBrowse link
G Git1 GIT ArfGAP 1 acts_upstream_of_or_within ISO PMID:17310244 MGI PMID:17310244 RGD:10047256 NCBI chrNW_004955481:3,671,728...3,681,279
Ensembl chrNW_004955481:3,670,111...3,685,051 		JBrowse link
G Msn moesin involved_in ISO (PMID:27405666) UniProt PMID:27405666 NCBI chrNW_004955475:5,301,856...5,370,378
Ensembl chrNW_004955475:5,301,910...5,370,691 		JBrowse link
G Nck2 NCK adaptor protein 2 acts_upstream_of_or_within ISO PMID:17310244 MGI PMID:17310244 RGD:10047256 NCBI chrNW_004955470:10,487,962...10,593,046
Ensembl chrNW_004955470:10,487,481...10,593,046 		JBrowse link
G Prf1 perforin 1 involved_in ISO (PMID:21438968) UniProt PMID:21438968 NCBI chrNW_004955437:20,700,912...20,705,076
Ensembl chrNW_004955437:20,700,718...20,706,929 		JBrowse link
negative regulation of immunological synapse formation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Havcr2 hepatitis A virus cellular receptor 2 involved_in ISO (PMID:24337741) UniProt PMID:24337741 NCBI chrNW_004955408:11,289,920...11,311,216
Ensembl chrNW_004955408:11,291,937...11,311,320 		JBrowse link
G Lgals3 galectin 3 involved_in ISO (PMID:19706535) BHF-UCL PMID:19706535 NCBI chrNW_004955409:8,448,120...8,452,437
Ensembl chrNW_004955409:8,447,774...8,452,438 		JBrowse link
positive regulation of glycoprotein biosynthetic process involved in immunological synapse formation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ccr7 C-C motif chemokine receptor 7 involved_in ISO (PMID:15845453) BHF-UCL PMID:15845453 NCBI chrNW_004955451:15,086,119...15,101,862
Ensembl chrNW_004955451:15,086,119...15,095,561 		JBrowse link
positive regulation of immunological synapse formation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ccr7 C-C motif chemokine receptor 7 involved_in ISO (PMID:15845453) BHF-UCL PMID:15845453 NCBI chrNW_004955451:15,086,119...15,101,862
Ensembl chrNW_004955451:15,086,119...15,095,561 		JBrowse link
G Nedd9 neural precursor cell expressed, developmentally down-regulated 9 involved_in ISO (PMID:27359298) UniProt PMID:27359298 NCBI chrNW_004955465:3,101,409...3,281,481
Ensembl chrNW_004955465:3,129,707...3,282,632 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 12561
    cellular process 12000
      cell recognition 127
        cell-cell recognition 60
          immunological synapse formation 18
            negative regulation of immunological synapse formation 2
            positive regulation of glycoprotein biosynthetic process involved in immunological synapse formation 1
            positive regulation of immunological synapse formation 2
            regulation of immunological synapse formation + 4
Path 2
Term Annotations click to browse term
  biological_process 12561
    cellular process 12000
      cell activation 1045
        leukocyte activation 910
          lymphocyte activation 739
            immunological synapse formation 18
              negative regulation of immunological synapse formation 2
              positive regulation of glycoprotein biosynthetic process involved in immunological synapse formation 1
              positive regulation of immunological synapse formation 2
              regulation of immunological synapse formation + 4
paths to the root