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ONTOLOGY REPORT - ANNOTATIONS


Term:immunological synapse formation
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Accession:GO:0001771 term browser browse the term
Definition:The formation of an area of close contact between a lymphocyte (T-, B-, or natural killer cell) and a target cell through the clustering of particular signaling and adhesion molecules and their associated membrane rafts on both the lymphocyte and target cell, which facilitates activation of the lymphocyte, transfer of membrane from the target cell to the lymphocyte, and in some situations killing of the target cell through release of secretory granules and/or death-pathway ligand-receptor interaction.
Synonyms:exact_synonym: formation of immunological synapse



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immunological synapse formation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G CCL19 C-C motif chemokine ligand 19 involved_in ISO (PMID:15845453) BHF-UCL PMID:15845453 NCBI chr 9:34,525,820...34,527,628
Ensembl chr 9:35,334,353...35,336,108
JBrowse link
G CCL21 C-C motif chemokine ligand 21 involved_in ISO (PMID:15845453) BHF-UCL PMID:15845453 NCBI chr 9:34,545,248...34,546,801
Ensembl chr 9:35,353,768...35,354,924
JBrowse link
G CD2AP CD2 associated protein involved_in
acts_upstream_of_or_within
IEA
ISO
(PMID:14512504) Ensembl
MGI
PMID:14512504 GO_REF:0000107 NCBI chr 6:47,065,284...47,210,746
Ensembl chr 6:48,328,863...48,474,163
JBrowse link
G CD6 CD6 molecule involved_in IEA Ensembl GO_REF:0000107 NCBI chr11:56,269,585...56,283,516
Ensembl chr11:59,675,221...59,722,916
JBrowse link
G CD81 CD81 molecule involved_in IEA Ensembl GO_REF:0000107 NCBI chr11:2,400,503...2,421,132
Ensembl chr11:2,437,991...2,449,308
JBrowse link
G CORO1A coronin 1A NOT|involved_in ISO (PMID:24760828) UniProt PMID:24760828 Ensembl chr16:30,550,383...30,556,196 JBrowse link
G DLG1 discs large MAGUK scaffold protein 1 involved_in
acts_upstream_of_or_within
IEA
ISO
(PMID:15699074) Ensembl
MGI
PMID:15699074 GO_REF:0000107 NCBI chr 3:194,386,263...194,648,015
Ensembl chr 3:204,323,724...204,584,987
JBrowse link
G DOCK2 dedicator of cytokinesis 2 involved_in
acts_upstream_of_or_within
IEA
ISO
(PMID:12871644) Ensembl
MGI
PMID:12871644 GO_REF:0000107 NCBI chr 5:165,000,368...165,447,148
Ensembl chr 5:171,778,952...172,206,238
JBrowse link
G DOCK8 dedicator of cytokinesis 8 involved_in
acts_upstream_of_or_within
IEA
ISO
(PMID:22006977) Ensembl
MGI
PMID:22006977 GO_REF:0000107 NCBI chr 9:6,791...256,837
Ensembl chr 9:201,156...446,910
JBrowse link
G EPHB1 EPH receptor B1 acts_upstream_of_or_within ISO PMID:17310244 MGI PMID:17310244 RGD:10047256 NCBI chr 3:131,841,459...132,309,082
Ensembl chr 3:139,313,387...139,776,802
JBrowse link
G GIT1 GIT ArfGAP 1 acts_upstream_of_or_within ISO PMID:17310244 MGI PMID:17310244 RGD:10047256 NCBI chr17:27,185,025...27,201,146
Ensembl chr17:27,706,776...27,717,857
JBrowse link
G MSN moesin involved_in IEA Ensembl GO_REF:0000107 NCBI chr  X:54,785,309...54,859,364
Ensembl chr  X:64,781,550...64,933,292
JBrowse link
G NCK2 NCK adaptor protein 2 acts_upstream_of_or_within ISO PMID:17310244 MGI PMID:17310244 RGD:10047256 NCBI chr2A:95,939,197...96,089,163
Ensembl chr2A:106,898,547...106,976,363
JBrowse link
G PRF1 perforin 1 involved_in IEA Ensembl
TreeGrafter
GO_REF:0000107 GO_REF:0000118 NCBI chr10:67,071,141...67,078,057
Ensembl chr10:69,597,574...69,603,070
JBrowse link
negative regulation of immunological synapse formation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G HAVCR2 hepatitis A virus cellular receptor 2 involved_in IEA Ensembl GO_REF:0000107 NCBI chr 5:152,486,125...152,514,004
Ensembl chr 5:159,108,915...159,131,007
JBrowse link
G LGALS3 galectin 3 involved_in ISO (PMID:19706535) BHF-UCL PMID:19706535 NCBI chr14:35,715,850...35,732,263
Ensembl chr14:53,990,023...54,006,412
JBrowse link
positive regulation of glycoprotein biosynthetic process involved in immunological synapse formation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G CCR7 C-C motif chemokine receptor 7 involved_in IEA Ensembl GO_REF:0000107 NCBI chr17:16,720,236...16,731,955
Ensembl chr17:16,949,119...16,956,370
JBrowse link
positive regulation of immunological synapse formation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G CCR7 C-C motif chemokine receptor 7 involved_in IEA Ensembl GO_REF:0000107 NCBI chr17:16,720,236...16,731,955
Ensembl chr17:16,949,119...16,956,370
JBrowse link
G NEDD9 neural precursor cell expressed, developmentally down-regulated 9 involved_in IEA Ensembl GO_REF:0000107 NCBI chr 6:11,022,321...11,071,747
Ensembl chr 6:11,297,701...11,420,186
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 19444
    cellular process 18997
      cell recognition 161
        cell-cell recognition 81
          immunological synapse formation 18
            negative regulation of immunological synapse formation 2
            positive regulation of glycoprotein biosynthetic process involved in immunological synapse formation 1
            positive regulation of immunological synapse formation 2
            regulation of immunological synapse formation + 4
Path 2
Term Annotations click to browse term
  biological_process 19444
    cellular process 18997
      cell activation 1153
        leukocyte activation 994
          lymphocyte activation 808
            immunological synapse formation 18
              negative regulation of immunological synapse formation 2
              positive regulation of glycoprotein biosynthetic process involved in immunological synapse formation 1
              positive regulation of immunological synapse formation 2
              regulation of immunological synapse formation + 4
paths to the root