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ONTOLOGY REPORT - ANNOTATIONS

Term:mRNA regulatory element binding translation repressor activity
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Accession:GO:0000900 term browser browse the term
Definition:Antagonizes the ribosome-mediated translation of mRNA into a polypeptide via direct binding (through a selective and non-covalent interaction) to nucleic acid.
Synonyms:broad_synonym: translation repressor activity, nucleic acid binding
 xref: Reactome:R-HSA-5690886 "ACO1, IREB2 bind IREs in TFRC, ALAD, FTL, FTH1 mRNAs"


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mRNA regulatory element binding translation repressor activity term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Aco1 aconitase 1 enables ISO (PMID:1946430), (PMID:7983023), (PMID:8041788) RGD PMID:1946430 PMID:7983023 PMID:8041788 NCBI chr 5:55,259,841...55,315,872
Ensembl chr 5:55,259,827...55,316,391 		JBrowse link
G Cpeb1 cytoplasmic polyadenylation element binding protein 1 enables ISS
IBA
ISO		 GO_REF:0000024
GO_REF:0000033
(PMID:18752464)		 UniProt
GO_Central
RGD		 PMID:18752464 GO_REF:0000024 GO_REF:0000033 NCBI chr 1:135,300,048...135,407,688
Ensembl chr 1:135,300,461...135,409,760 		JBrowse link
G Cpeb2 cytoplasmic polyadenylation element binding protein 2 enables IDA
IBA
ISO		 PMID:22157746
GO_REF:0000033
(PMID:18752464)		 GO_Central
RGD		 PMID:18752464 PMID:22157746 GO_REF:0000033, RGD:8553654 NCBI chr14:67,787,503...67,839,973
Ensembl chr14:67,787,507...67,840,743 		JBrowse link
G Cpeb3 cytoplasmic polyadenylation element binding protein 3 enables IBA
ISO		 GO_REF:0000033
(PMID:22157746)		 GO_Central
RGD		 PMID:22157746 GO_REF:0000033 NCBI chr 1:234,749,138...234,931,219
Ensembl chr 1:234,751,733...234,931,560 		JBrowse link
G Cpeb4 cytoplasmic polyadenylation element binding protein 4 enables IBA GO_REF:0000033 GO_Central GO_REF:0000033 NCBI chr10:15,717,794...15,780,482
Ensembl chr10:15,717,794...15,780,603 		JBrowse link
G Dhfr dihydrofolate reductase enables ISO (PMID:8490020) RGD PMID:8490020 NCBI chr 2:23,585,876...23,611,199
Ensembl chr 2:23,586,031...23,613,713 		JBrowse link
G Ireb2 iron responsive element binding protein 2 enables ISO (PMID:1946430), (PMID:7983023), (PMID:8041788) RGD PMID:1946430 PMID:7983023 PMID:8041788 NCBI chr 8:55,228,080...55,311,613
Ensembl chr 8:55,228,085...55,311,611 		JBrowse link
G Paip2 poly(A) binding protein interacting protein 2 enables IEA GO_REF:0000002 InterPro GO_REF:0000002 NCBI chr18:27,199,762...27,218,359
Ensembl chr18:27,199,796...27,214,863
Ensembl chr 1:27,199,796...27,214,863 		JBrowse link
G Paip2b poly(A) binding protein interacting protein 2B enables ISO (PMID:16804161) RGD PMID:16804161 NCBI chr 4:116,292,001...116,323,387
Ensembl chr 4:116,292,020...116,323,379 		JBrowse link
G Pura purine rich element binding protein A enables ISO
IEA		 (PMID:12933792)
GO_REF:0000107		 RGD
Ensembl		 PMID:12933792 GO_REF:0000107 NCBI chr18:27,885,071...27,905,509
Ensembl chr18:27,884,556...27,905,513 		JBrowse link
G Purb purine rich element binding protein B enables IDA PMID:12933792 HGNC-UCL PMID:12933792 RGD:1581942 NCBI chr14:81,342,374...81,344,857
Ensembl chr14:81,336,448...81,351,432 		JBrowse link
G Rara retinoic acid receptor, alpha IDA RGD PMID:19073915 RGD:2314253 NCBI chr10:83,883,490...83,928,932
Ensembl chr10:83,893,384...83,928,142 		JBrowse link
G Shmt1 serine hydroxymethyltransferase 1 enables ISO (PMID:10995219) RGD PMID:10995219 NCBI chr10:45,468,698...45,490,833
Ensembl chr10:45,468,700...45,497,820 		JBrowse link
G Tyms thymidylate synthetase enables ISO (PMID:1924359) RGD PMID:1924359 NCBI chr 9:113,313,454...113,329,551
Ensembl chr 9:113,313,452...113,329,536 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  molecular_function 21087
    translation regulator activity 344
      translation repressor activity 220
        mRNA regulatory element binding translation repressor activity 14
Path 2
Term Annotations click to browse term
  molecular_function 21087
    binding 18096
      nucleic acid binding 3967
        translation regulator activity, nucleic acid binding 123
          mRNA regulatory element binding translation repressor activity 14
paths to the root