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ONTOLOGY REPORT - ANNOTATIONS

Term:mRNA regulatory element binding translation repressor activity
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Accession:GO:0000900 term browser browse the term
Definition:Antagonizes the ribosome-mediated translation of mRNA into a polypeptide via direct binding (through a selective and non-covalent interaction) to nucleic acid.
Synonyms:broad_synonym: translation repressor activity, nucleic acid binding
 xref: Reactome:R-HSA-5690886 "ACO1, IREB2 bind IREs in TFRC, ALAD, FTL, FTH1 mRNAs"


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mRNA regulatory element binding translation repressor activity term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ACO1 aconitase 1 enables ISO (PMID:1946430), (PMID:7983023), (PMID:8041788) Reactome PMID:1946430 PMID:7983023 PMID:8041788 NCBI chr10:33,937,833...34,001,895
Ensembl chr10:33,937,833...34,001,900 		JBrowse link
G CPEB1 cytoplasmic polyadenylation element binding protein 1 enables IBA GO_Central GO_REF:0000033 NCBI chr 7:52,329,054...52,382,408
Ensembl chr 7:52,304,472...52,383,732 		JBrowse link
G CPEB2 cytoplasmic polyadenylation element binding protein 2 enables IBA GO_Central GO_REF:0000033 NCBI chr 8:10,401,350...10,472,141
Ensembl chr 8:10,401,350...10,472,136 		JBrowse link
G CPEB3 cytoplasmic polyadenylation element binding protein 3 enables IBA GO_Central GO_REF:0000033 NCBI chr14:103,675,164...103,871,245
Ensembl chr14:103,675,175...103,871,227 		JBrowse link
G CPEB4 cytoplasmic polyadenylation element binding protein 4 enables IBA GO_Central GO_REF:0000033 NCBI chr16:50,430,345...50,499,086
Ensembl chr16:50,430,348...50,498,938 		JBrowse link
G DHFR dihydrofolate reductase enables ISO (PMID:8490020) CAFA PMID:8490020 NCBI chr 2:89,230,660...89,255,830 JBrowse link
G IREB2 iron responsive element binding protein 2 enables ISO (PMID:1946430), (PMID:7983023), (PMID:8041788) Reactome PMID:1946430 PMID:7983023 PMID:8041788 NCBI chr 7:47,481,539...47,529,199
Ensembl chr 7:47,478,706...47,529,242 		JBrowse link
G PAIP2 poly(A) binding protein interacting protein 2 enables IEA InterPro GO_REF:0000002 NCBI chr 2:141,237,417...141,260,207
Ensembl chr 2:141,237,438...141,261,125 		JBrowse link
G PAIP2B poly(A) binding protein interacting protein 2B enables IEA InterPro
Ensembl		 GO_REF:0000002 GO_REF:0000107 NCBI chr 3:71,452,753...71,500,176
Ensembl chr 3:71,452,538...71,499,500 		JBrowse link
G PURA purine rich element binding protein A enables IEA Ensembl GO_REF:0000107 NCBI chr 2:141,877,775...141,899,259
Ensembl chr 2:141,884,155...141,886,330 		JBrowse link
G PURB purine rich element binding protein B enables ISO PMID:12933792 HGNC-UCL PMID:12933792 RGD:1581942 NCBI chr18:50,510,010...50,518,965
Ensembl chr18:50,510,182...50,511,108 		JBrowse link
G RARA retinoic acid receptor alpha ISO RGD PMID:19073915 RGD:2314253 NCBI chr12:22,047,449...22,085,759
Ensembl chr12:22,047,443...22,085,673 		JBrowse link
G SHMT1 serine hydroxymethyltransferase 1 enables IEA Ensembl GO_REF:0000107 NCBI chr12:60,414,421...60,435,451
Ensembl chr12:60,416,463...60,435,450 		JBrowse link
G TYMS thymidylate synthetase enables IEA Ensembl GO_REF:0000107 NCBI chr 6:105,642,730...105,660,279
Ensembl chr 6:105,642,381...105,660,578 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  molecular_function 19428
    translation regulator activity 301
      translation repressor activity 174
        mRNA regulatory element binding translation repressor activity 14
Path 2
Term Annotations click to browse term
  molecular_function 19428
    binding 16980
      nucleic acid binding 4103
        translation regulator activity, nucleic acid binding 127
          mRNA regulatory element binding translation repressor activity 14
paths to the root