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ONTOLOGY REPORT - ANNOTATIONS

Term:mRNA regulatory element binding translation repressor activity
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Accession:GO:0000900 term browser browse the term
Definition:Antagonizes the ribosome-mediated translation of mRNA into a polypeptide via direct binding (through a selective and non-covalent interaction) to nucleic acid.
Synonyms:broad_synonym: translation repressor activity, nucleic acid binding
 xref: Reactome:R-HSA-5690886 "ACO1, IREB2 bind IREs in TFRC, ALAD, FTL, FTH1 mRNAs"


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mRNA regulatory element binding translation repressor activity term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ACO1 aconitase 1 enables EXP (PMID:1946430), (PMID:7983023), (PMID:8041788) Reactome PMID:1946430 PMID:7983023 PMID:8041788 NCBI chr 9:32,384,643...32,454,769
Ensembl chr 9:32,384,603...32,454,769 		JBrowse link
G CELF1 CUGBP Elav-like family member 1 enables NAS (PMID:10893231) UniProt PMID:10893231 NCBI chr11:47,465,937...47,565,539
Ensembl chr11:47,465,933...47,565,569 		JBrowse link
G CELF4 CUGBP Elav-like family member 4 enables NAS (PMID:10893231) UniProt PMID:10893231 NCBI chr18:37,242,844...37,565,798
Ensembl chr18:37,243,040...37,565,827 		JBrowse link
G CPEB1 cytoplasmic polyadenylation element binding protein 1 enables ISS
IBA		 UniProt
GO_Central		 GO_REF:0000024 GO_REF:0000033 NCBI chr15:82,543,201...82,648,795
Ensembl chr15:82,543,201...82,648,861 		JBrowse link
G CPEB2 cytoplasmic polyadenylation element binding protein 2 enables ISS
IBA		 UniProt
GO_Central		 GO_REF:0000024 GO_REF:0000033 NCBI chr 4:15,002,481...15,070,151
Ensembl chr 4:15,002,481...15,070,153 		JBrowse link
G CPEB3 cytoplasmic polyadenylation element binding protein 3 enables ISS
IBA		 UniProt
GO_Central		 GO_REF:0000024 GO_REF:0000033 NCBI chr10:92,046,692...92,291,233
Ensembl chr10:92,046,692...92,291,078 		JBrowse link
G CPEB4 cytoplasmic polyadenylation element binding protein 4 enables IBA GO_Central GO_REF:0000033 NCBI chr 5:173,888,349...173,961,980
Ensembl chr 5:173,888,349...173,961,980 		JBrowse link
G DHFR dihydrofolate reductase enables IDA (PMID:8490020) CAFA PMID:8490020 NCBI chr 5:80,626,226...80,654,983
Ensembl chr 5:80,626,226...80,654,983 		JBrowse link
G DHFRP1 dihydrofolate reductase pseudogene 1 enables IDA (PMID:8490020) CAFA PMID:8490020 NCBI chr18:26,167,862...26,171,357
Ensembl chr18:26,170,726...26,171,284 		JBrowse link
G IREB2 iron responsive element binding protein 2 enables EXP (PMID:1946430), (PMID:7983023), (PMID:8041788) Reactome PMID:1946430 PMID:7983023 PMID:8041788 NCBI chr15:78,437,431...78,501,453
Ensembl chr15:78,437,431...78,501,453 		JBrowse link
G PAIP2 poly(A) binding protein interacting protein 2 enables IEA InterPro GO_REF:0000002 NCBI chr 5:139,341,854...139,369,717
Ensembl chr 5:139,341,587...139,369,720 		JBrowse link
G PAIP2B poly(A) binding protein interacting protein 2B enables IDA
IEA		 (PMID:16804161) HGNC-UCL
InterPro		 PMID:16804161 GO_REF:0000002 NCBI chr 2:71,182,738...71,227,103
Ensembl chr 2:71,182,738...71,227,103 		JBrowse link
G PURA purine rich element binding protein A enables IEA
ISS		 Ensembl
BHF-UCL		 GO_REF:0000024 GO_REF:0000107 NCBI chr 5:140,114,109...140,125,619
Ensembl chr 5:140,107,777...140,125,619 		JBrowse link
G PURB purine rich element binding protein B enables ISS BHF-UCL GO_REF:0000024 NCBI chr 7:44,876,299...44,885,530
Ensembl chr 7:44,876,299...44,885,530 		JBrowse link
G RARA retinoic acid receptor alpha enables ISO
IEA		 RGD
Ensembl		 PMID:19073915 GO_REF:0000107 RGD:2314253 NCBI chr17:40,309,180...40,357,643
Ensembl chr17:40,309,180...40,357,643 		JBrowse link
G SHMT1 serine hydroxymethyltransferase 1 enables IDA (PMID:10995219) CAFA PMID:10995219 NCBI chr17:18,327,873...18,363,550
Ensembl chr17:18,327,873...18,363,550 		JBrowse link
G TYMS thymidylate synthetase enables IDA (PMID:1924359) CAFA PMID:1924359 NCBI chr18:657,653...673,578
Ensembl chr18:657,653...673,578 		JBrowse link
G ZNF540 zinc finger protein 540 enables IMP (PMID:16815308) UniProt PMID:16815308 NCBI chr19:37,551,374...37,614,179
Ensembl chr19:37,551,406...37,614,179 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  molecular_function 19542
    translation regulator activity 503
      translation repressor activity 374
        mRNA regulatory element binding translation repressor activity 18
Path 2
Term Annotations click to browse term
  molecular_function 19542
    binding 18020
      nucleic acid binding 4629
        translation regulator activity, nucleic acid binding 133
          mRNA regulatory element binding translation repressor activity 18
paths to the root