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ONTOLOGY REPORT - ANNOTATIONS

Term:mRNA regulatory element binding translation repressor activity
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Accession:GO:0000900 term browser browse the term
Definition:Antagonizes the ribosome-mediated translation of mRNA into a polypeptide via direct binding (through a selective and non-covalent interaction) to nucleic acid.
Synonyms:broad_synonym: translation repressor activity, nucleic acid binding
 xref: Reactome:R-HSA-5690886 "ACO1, IREB2 bind IREs in TFRC, ALAD, FTL, FTH1 mRNAs"


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mRNA regulatory element binding translation repressor activity term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ACO1 aconitase 1 enables ISO (PMID:1946430), (PMID:7983023), (PMID:8041788) Reactome PMID:1946430 PMID:7983023 PMID:8041788 NCBI chr11:49,699,072...49,758,783
Ensembl chr11:49,699,109...49,923,257 		JBrowse link
G CPEB1 cytoplasmic polyadenylation element binding protein 1 enables IBA GO_Central GO_REF:0000033 NCBI chr 3:54,405,140...54,499,614
Ensembl chr 3:54,405,717...54,500,221 		JBrowse link
G CPEB2 cytoplasmic polyadenylation element binding protein 2 enables IBA GO_Central GO_REF:0000033 NCBI chr 3:65,200,175...65,277,353
Ensembl chr 3:65,203,759...65,267,967 		JBrowse link
G CPEB3 cytoplasmic polyadenylation element binding protein 3 enables IBA GO_Central GO_REF:0000033 NCBI chr28:6,523,894...6,724,010
Ensembl chr28:6,529,212...6,723,454 		JBrowse link
G CPEB4 cytoplasmic polyadenylation element binding protein 4 enables IBA GO_Central GO_REF:0000033
G DHFR dihydrofolate reductase enables ISO (PMID:8490020) CAFA PMID:8490020 NCBI chr 3:26,521,214...26,556,065 JBrowse link
G IREB2 iron responsive element binding protein 2 enables ISO (PMID:1946430), (PMID:7983023), (PMID:8041788) Reactome PMID:1946430 PMID:7983023 PMID:8041788 NCBI chr13:38,398,445...38,441,128
Ensembl chr13:38,400,591...38,441,015 		JBrowse link
G PAIP2 poly(A) binding protein interacting protein 2 enables IEA InterPro GO_REF:0000002 NCBI chr 2:34,671,130...34,695,974
Ensembl chr 2:34,671,150...34,695,299 		JBrowse link
G PAIP2B poly(A) binding protein interacting protein 2B enables IEA InterPro GO_REF:0000002 NCBI chr17:51,381,891...51,388,964
Ensembl chr17:51,385,194...51,413,360 		JBrowse link
G PURA purine rich element binding protein A enables IEA Ensembl GO_REF:0000107 NCBI chr 2:35,325,630...35,345,366
Ensembl chr 2:35,330,902...35,332,835 		JBrowse link
G PURB purine rich element binding protein B enables ISO PMID:12933792 HGNC-UCL PMID:12933792 RGD:1581942
G RARA retinoic acid receptor alpha ISO RGD PMID:19073915 RGD:2314253 NCBI chr 9:22,254,803...22,298,614
Ensembl chr 9:22,254,806...22,289,459 		JBrowse link
G SHMT1 serine hydroxymethyltransferase 1 enables ISO (PMID:10995219) CAFA PMID:10995219 NCBI chr 5:41,221,531...41,248,653
Ensembl chr 5:41,221,562...41,253,166 		JBrowse link
G TYMS thymidylate synthetase enables IEA Ensembl GO_REF:0000107 NCBI chr 7:67,487,927...67,497,747
Ensembl chr 7:67,487,927...67,497,747 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  molecular_function 21949
    translation regulator activity 335
      translation repressor activity 220
        mRNA regulatory element binding translation repressor activity 14
Path 2
Term Annotations click to browse term
  molecular_function 21949
    binding 19839
      nucleic acid binding 6751
        translation regulator activity, nucleic acid binding 113
          mRNA regulatory element binding translation repressor activity 14
paths to the root