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ONTOLOGY REPORT - ANNOTATIONS

Term:mRNA regulatory element binding translation repressor activity
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Accession:GO:0000900 term browser browse the term
Definition:Antagonizes the ribosome-mediated translation of mRNA into a polypeptide via direct binding (through a selective and non-covalent interaction) to nucleic acid.
Synonyms:broad_synonym: translation repressor activity, nucleic acid binding
 xref: Reactome:R-HSA-5690886 "ACO1, IREB2 bind IREs in TFRC, ALAD, FTL, FTH1 mRNAs"

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mRNA regulatory element binding translation repressor activity term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Aco1 aconitase 1 enables ISO (PMID:1946430), (PMID:7983023), (PMID:8041788) Reactome PMID:1946430 PMID:7983023 PMID:8041788 NCBI chrNW_004955472:3,141,473...3,170,959
Ensembl chrNW_004955472:3,141,257...3,170,959 		JBrowse link
G Cpeb1 cytoplasmic polyadenylation element binding protein 1 enables ISO (PMID:18752464) UniProt PMID:18752464 NCBI chrNW_004955416:13,963,300...14,038,691
Ensembl chrNW_004955416:13,981,657...14,039,705 		JBrowse link
G Cpeb2 cytoplasmic polyadenylation element binding protein 2 enables ISO PMID:22157746
(PMID:18752464)		 UniProt PMID:18752464 PMID:22157746 RGD:8553654 NCBI chrNW_004955480:8,853,449...8,906,859 JBrowse link
G Cpeb3 cytoplasmic polyadenylation element binding protein 3 enables ISO (PMID:22157746) UniProt PMID:22157746 NCBI chrNW_004955425:1,032,446...1,224,300
Ensembl chrNW_004955425:1,057,575...1,224,300 		JBrowse link
G Dhfr dihydrofolate reductase enables ISO (PMID:8490020) CAFA PMID:8490020 NCBI chrNW_004955418:29,274,170...29,283,028 JBrowse link
G Ireb2 iron responsive element binding protein 2 enables ISO (PMID:1946430), (PMID:7983023), (PMID:8041788) Reactome PMID:1946430 PMID:7983023 PMID:8041788 NCBI chrNW_004955450:852,554...898,908
Ensembl chrNW_004955450:852,554...900,011 		JBrowse link
G Paip2b poly(A) binding protein interacting protein 2B enables ISO (PMID:16804161) HGNC-UCL PMID:16804161 NCBI chrNW_004955424:14,157,358...14,190,865
Ensembl chrNW_004955424:14,156,768...14,190,865 		JBrowse link
G Pura purine rich element binding protein A enables ISO (PMID:12933792) HGNC-UCL PMID:12933792 NCBI chrNW_004955418:538,883...548,605 JBrowse link
G Purb purine rich element binding protein B enables ISO PMID:12933792 HGNC-UCL PMID:12933792 RGD:1581942 NCBI chrNW_004955456:7,322,973...7,323,529 JBrowse link
G Rara retinoic acid receptor alpha ISO RGD PMID:19073915 RGD:2314253 NCBI chrNW_004955451:14,876,663...14,917,134
Ensembl chrNW_004955451:14,897,726...14,917,134 		JBrowse link
G Shmt1 serine hydroxymethyltransferase 1 enables ISO (PMID:10995219) CAFA PMID:10995219 NCBI chrNW_004955478:10,972,791...11,001,535
Ensembl chrNW_004955478:10,978,139...11,001,202 		JBrowse link
G Tyms thymidylate synthetase enables ISO (PMID:1924359) CAFA PMID:1924359 NCBI chrNW_004955402:9,295,862...9,304,952
Ensembl chrNW_004955402:9,296,321...9,306,631 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  molecular_function 14380
    translation regulator activity 83
      translation repressor activity 21
        mRNA regulatory element binding translation repressor activity 12
Path 2
Term Annotations click to browse term
  molecular_function 14380
    binding 13664
      nucleic acid binding 1892
        translation regulator activity, nucleic acid binding 66
          mRNA regulatory element binding translation repressor activity 12
paths to the root