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ONTOLOGY REPORT - ANNOTATIONS

Term:mRNA regulatory element binding translation repressor activity
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Accession:GO:0000900 term browser browse the term
Definition:Antagonizes the ribosome-mediated translation of mRNA into a polypeptide via direct binding (through a selective and non-covalent interaction) to nucleic acid.
Synonyms:broad_synonym: translation repressor activity, nucleic acid binding
 xref: Reactome:R-HSA-5690886 "ACO1, IREB2 bind IREs in TFRC, ALAD, FTL, FTH1 mRNAs"


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mRNA regulatory element binding translation repressor activity term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ACO1 aconitase 1 enables ISO (PMID:1946430), (PMID:7983023), (PMID:8041788) Reactome PMID:1946430 PMID:7983023 PMID:8041788 NCBI chr 9:32,157,763...32,225,116
Ensembl chr 9:32,967,993...33,035,177 		JBrowse link
G CPEB1 cytoplasmic polyadenylation element binding protein 1 enables IEA TreeGrafter GO_REF:0000118 NCBI chr15:62,949,264...63,053,994
Ensembl chr15:80,443,096...80,526,948 		JBrowse link
G CPEB2 cytoplasmic polyadenylation element binding protein 2 enables ISO PMID:22157746
(PMID:18752464)		 UniProt PMID:18752464 PMID:22157746 RGD:8553654 NCBI chr 4:9,431,573...9,499,036 JBrowse link
G CPEB3 cytoplasmic polyadenylation element binding protein 3 enables IEA TreeGrafter GO_REF:0000118 NCBI chr10:88,794,186...89,038,808
Ensembl chr10:92,320,240...92,506,089 		JBrowse link
G CPEB4 cytoplasmic polyadenylation element binding protein 4 enables IEA TreeGrafter GO_REF:0000118 NCBI chr 5:169,228,648...169,300,612
Ensembl chr 5:176,133,495...176,205,388 		JBrowse link
G DHFR dihydrofolate reductase enables IEA Ensembl GO_REF:0000107 NCBI chr 5:34,663,210...34,689,467
Ensembl chr 5:34,938,548...34,967,003 		JBrowse link
G IREB2 iron responsive element binding protein 2 enables ISO (PMID:1946430), (PMID:7983023), (PMID:8041788) Reactome PMID:1946430 PMID:7983023 PMID:8041788 NCBI chr15:57,367,314...57,430,322
Ensembl chr15:76,331,610...76,394,476 		JBrowse link
G LOC100986487 zinc finger protein 540 enables IEA Ensembl GO_REF:0000107 NCBI chr19:34,536,659...34,555,850
Ensembl chr19:42,213,165...42,227,855 		JBrowse link
G PAIP2 poly(A) binding protein interacting protein 2 enables IEA InterPro GO_REF:0000002 NCBI chr 5:134,712,834...134,740,747
Ensembl chr 5:140,835,320...140,862,743 		JBrowse link
G PAIP2B poly(A) binding protein interacting protein 2B enables IEA Ensembl
InterPro		 GO_REF:0000002 GO_REF:0000107 NCBI chr2A:71,227,562...71,271,642
Ensembl chr2A:72,733,750...72,772,036 		JBrowse link
G PURA purine rich element binding protein A enables IEA Ensembl GO_REF:0000107 NCBI chr 5:135,541,865...135,610,526
Ensembl chr 5:141,659,224...141,727,870
Ensembl chr 5:141,659,224...141,727,870 		JBrowse link
G PURB purine rich element binding protein B enables ISO PMID:12933792 HGNC-UCL PMID:12933792 RGD:1581942 NCBI chr 7:45,590,183...45,600,089
Ensembl chr 7:45,667,233...45,668,159 		JBrowse link
G RARA retinoic acid receptor alpha ISO RGD PMID:19073915 RGD:2314253 NCBI chr17:16,932,485...16,980,958 JBrowse link
G SHMT1 serine hydroxymethyltransferase 1 enables IEA Ensembl GO_REF:0000107 NCBI chr17:32,870,949...32,905,690
Ensembl chr17:37,849,206...37,884,220 		JBrowse link
G TYMS thymidylate synthetase enables IEA Ensembl GO_REF:0000107 NCBI chr18:13,653,085...13,668,478
Ensembl chr18:17,295,182...17,310,320 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  molecular_function 19165
    translation regulator activity 126
      translation repressor activity 25
        mRNA regulatory element binding translation repressor activity 15
Path 2
Term Annotations click to browse term
  molecular_function 19165
    binding 17477
      nucleic acid binding 4559
        translation regulator activity, nucleic acid binding 104
          mRNA regulatory element binding translation repressor activity 15
paths to the root