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ONTOLOGY REPORT - ANNOTATIONS

Term:3-beta-hydroxysteroid dehydrogenase [NAD(P)+]/C4-decarboxylase activity
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Accession:GO:0000252 term browser browse the term
Definition:Catalysis of the reaction: a 3-beta-hydroxysteroid-4-alpha-carboxylate + NADP+ = a 3-oxosteroid + CO2 + NADPH.
Synonyms:exact_synonym: 3beta-hydroxy-4beta-methyl-5alpha-cholest-7-ene-4alpha-carboxylate:NAD(P)+ 3-oxidoreductase (decarboxylating);   C-3 sterol dehydrogenase (C-4 sterol decarboxylase) activity
 related_synonym: 3beta-hydroxy-4alpha-methylcholestenecarboxylate 3-dehydrogenase (decarboxylating);   3beta-hydroxy-4beta-methylcholestenecarboxylate 3-dehydrogenase (decarboxylating);   3beta-hydroxy-4beta-methylcholestenoate dehydrogenase activity;   C-3 sterol dehydrogenase (C-4 decarboxylase) activity;   C-3 sterol dehydrogenase activity;   sterol 4alpha-carboxylic decarboxylase activity;   sterol-4-carboxylate 3-dehydrogenase (decarboxylating) activity;   sterol-4alpha-carboxylate 3-dehydrogenase (decarboxylating)
 xref: EC:1.1.1.170;   reactome:R-HSA-194642 "4-methyl,4-carboxycholesta-8(9),24-dien-3beta-ol is decarboxylated and oxidized to form 4-methylcholesta-8(9),24-dien-3-one";   reactome:R-HSA-194718 "4-carboxycholesta-8(9),24-dien-3beta-ol is decarboxylated and oxidized to form cholesta-8(9),24-dien-3-one (zymosterone)"


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3-beta-hydroxysteroid dehydrogenase [NAD(P)+]/C4-decarboxylase activity term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Nsdhl NAD(P) dependent steroid dehydrogenase-like enables IEA GO_REF:0000003 UniProt GO_REF:0000003 NCBI chr  X:150,775,034...150,807,161
Ensembl chr  X:150,775,080...150,807,142 		JBrowse link
3-beta-hydroxysteroid dehydrogenase (NAD+)/C4-decarboxylase activity term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Nsdhl NAD(P) dependent steroid dehydrogenase-like enables IEA GO_REF:0000116 RHEA GO_REF:0000116 NCBI chr  X:150,775,034...150,807,161
Ensembl chr  X:150,775,080...150,807,142 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  molecular_function 20633
    catalytic activity 6032
      oxidoreductase activity 854
        steroid dehydrogenase activity 41
          steroid dehydrogenase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor 30
            3-beta-hydroxysteroid dehydrogenase [NAD(P)+]/C4-decarboxylase activity 1
              3-beta-hydroxysteroid dehydrogenase (NAD+)/C4-decarboxylase activity 1
Path 2
Term Annotations click to browse term
  molecular_function 20633
    catalytic activity 6032
      oxidoreductase activity 854
        oxidoreductase activity, acting on CH-OH group of donors 161
          oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor 152
            steroid dehydrogenase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor 30
              3-beta-hydroxysteroid dehydrogenase [NAD(P)+]/C4-decarboxylase activity 1
                3-beta-hydroxysteroid dehydrogenase (NAD+)/C4-decarboxylase activity 1
paths to the root