ONTOLOGY REPORT - ANNOTATIONS
Term: exosome (RNase complex)
Accession: GO:0000178
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Definition: A ribonuclease complex that has 3-prime to 5-prime exoribonuclease activity and possibly endoribonuclease activity, producing 5-prime-phosphomonoesters. Participates in a multitude of cellular RNA processing and degradation events preventing nuclear export and/or translation of aberrant RNAs. Restricted to processing linear and circular single-stranded RNAs (ssRNA) only. RNAs with complex secondary structures may have to be unwound or pre-processed by co-factors prior to entering the complex, esp if the 3-prime end is structured.
Comment: Note that this term should not be confused with 'exosome' used in the context of vesicles released from multivesicular bodies.
Synonyms: exact_synonym: exosome (ribonucleasease complex); exosome multienzyme ribonuclease complex
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C1d
C1D nuclear receptor corepressor
part_of
IBA
GO_REF:0000033
GO_Central
GO_REF:0000033
NCBI chr14:91,660,951...91,673,177
Ensembl chr14:91,660,989...91,672,852
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Exosc1
exosome component 1
part_of
ISO
(PMID:20531389)
RGD
PMID:20531389
NCBI chr 1:240,734,777...240,745,431
Ensembl chr 1:240,734,773...240,745,438
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Exosc10
exosome component 10
part_of
ISO
(PMID:20531389)
RGD
PMID:20531389
NCBI chr 5:158,995,313...159,018,940
Ensembl chr 5:158,995,313...159,018,940
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Exosc2
exosome component 2
part_of
ISO
(PMID:12419256), (PMID:20531389)
RGD
PMID:12419256 PMID:20531389
NCBI chr 3:14,962,930...14,973,645
Ensembl chr 3:14,962,917...14,973,575
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Exosc3
exosome component 3
part_of
ISO
(PMID:20531389)
RGD
PMID:20531389
NCBI chr 5:59,573,849...59,579,065
Ensembl chr 5:59,573,886...59,579,060
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Exosc4
exosome component 4
part_of
ISO
(PMID:20531389)
RGD
PMID:20531389
NCBI chr 7:108,047,831...108,050,573
Ensembl chr 7:108,047,831...108,050,573
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Exosc5
exosome component 5
part_of
ISO
(PMID:20531389)
RGD
PMID:20531389
NCBI chr 1:81,168,128...81,177,266
Ensembl chr 1:81,166,023...81,177,265
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Exosc6
exosome component 6
part_of
ISO
(PMID:20531389)
RGD
PMID:20531389
NCBI chr19:39,022,171...39,023,585
Ensembl chr19:39,022,183...39,023,515
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Exosc7
exosome component 7
part_of
ISO
(PMID:20531389)
RGD
PMID:20531389
NCBI chr 8:122,773,607...122,798,943
Ensembl chr 8:122,773,591...122,799,270
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Exosc8
exosome component 8
part_of
ISO
(PMID:20531389)
RGD
PMID:20531389
NCBI chr 2:138,930,405...138,937,009
Ensembl chr 2:138,930,405...138,936,928
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Exosc9
exosome component 9
part_of
ISS IEA ISO
GO_REF:0000024 GO_REF:0000043 (PMID:20531389)
UniProt RGD
PMID:20531389
GO_REF:0000024 GO_REF:0000043
NCBI chr 2:119,416,028...119,426,981
Ensembl chr 2:119,388,715...119,427,051
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Mphosph6
M phase phosphoprotein 6
part_of located_in
ISO
(PMID:20531389) (PMID:11719186)
RGD
PMID:11719186 PMID:20531389
NCBI chr19:45,860,152...45,870,117
Ensembl chr19:45,860,154...45,870,170
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Mtrex
Mtr4 exosome RNA helicase
located_in
ISO
(PMID:11719186)
RGD
PMID:11719186
NCBI chr 2:44,500,326...44,560,624
Ensembl chr 2:44,461,444...44,560,627
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Zfc3h1
zinc finger, C3H1-type containing
part_of
IBA
GO_REF:0000033
GO_Central
GO_REF:0000033
NCBI chr 7:51,008,251...51,064,666
Ensembl chr 7:51,007,984...51,064,661
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Zfp36
zinc finger protein 36
part_of NOT|located_in
IEA ISS ISO
GO_REF:0000043 GO_REF:0000024 (PMID:11719186)
UniProt RGD
PMID:11719186
GO_REF:0000024 GO_REF:0000043
NCBI chr 1:83,669,084...83,671,564
Ensembl chr 1:83,669,084...83,671,564
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Carhsp1
calcium regulated heat stable protein 1
located_in part_of
ISS ISO
GO_REF:0000024 (PMID:21078874)
UniProt RGD
PMID:21078874
GO_REF:0000024
NCBI chr10:6,946,036...6,960,556
Ensembl chr10:6,946,959...7,020,019
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Dis3
DIS3 homolog, exosome endoribonuclease and 3'-5' exoribonuclease
part_of
IBA
GO_REF:0000033
GO_Central
GO_REF:0000033
NCBI chr15:75,820,040...75,850,450
Ensembl chr15:75,823,436...75,850,642
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Dis3l
DIS3-like exosome 3'-5' exoribonuclease
part_of
ISO IBA ISS
(PMID:20531386), (PMID:20531389) GO_REF:0000033 GO_REF:0000024
RGD GO_Central UniProt
PMID:20531386 PMID:20531389
GO_REF:0000024 GO_REF:0000033
NCBI chr 8:64,803,925...64,840,306
Ensembl chr 8:64,803,927...64,840,165
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Exosc2
exosome component 2
part_of
IBA
GO_REF:0000033
GO_Central
GO_REF:0000033
NCBI chr 3:14,962,930...14,973,645
Ensembl chr 3:14,962,917...14,973,575
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Exosc3
exosome component 3
part_of
ISO IBA
(PMID:11110791) GO_REF:0000033
RGD GO_Central
PMID:11110791
GO_REF:0000033
NCBI chr 5:59,573,849...59,579,065
Ensembl chr 5:59,573,886...59,579,060
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Exosc4
exosome component 4
part_of
IBA
GO_REF:0000033
GO_Central
GO_REF:0000033
NCBI chr 7:108,047,831...108,050,573
Ensembl chr 7:108,047,831...108,050,573
G
Exosc5
exosome component 5
part_of
IBA
GO_REF:0000033
GO_Central
GO_REF:0000033
NCBI chr 1:81,168,128...81,177,266
Ensembl chr 1:81,166,023...81,177,265
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Exosc6
exosome component 6
part_of
IBA
GO_REF:0000033
GO_Central
GO_REF:0000033
NCBI chr19:39,022,171...39,023,585
Ensembl chr19:39,022,183...39,023,515
G
Exosc7
exosome component 7
part_of
IBA
GO_REF:0000033
GO_Central
GO_REF:0000033
NCBI chr 8:122,773,607...122,798,943
Ensembl chr 8:122,773,591...122,799,270
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Exosc8
exosome component 8
part_of
IBA
GO_REF:0000033
GO_Central
GO_REF:0000033
NCBI chr 2:138,930,405...138,937,009
Ensembl chr 2:138,930,405...138,936,928
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Exosc9
exosome component 9
part_of
IBA
GO_REF:0000033
GO_Central
GO_REF:0000033
NCBI chr 2:119,416,028...119,426,981
Ensembl chr 2:119,388,715...119,427,051
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Gtpbp1
GTP binding protein 1
part_of
IDA
PMID:21515746
UniProt
PMID:21515746
RGD:8553842
NCBI chr 7:111,248,254...111,272,705
Ensembl chr 7:111,248,254...111,272,705
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Pnpt1
polyribonucleotide nucleotidyltransferase 1
part_of
ISO
(PMID:19509288), (PMID:29967381)
RGD
PMID:19509288 PMID:29967381
NCBI chr14:102,877,553...102,908,696
Ensembl chr14:102,877,553...102,908,696
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Supv3l1
Suv3 like RNA helicase
part_of
ISS ISO IEA IBA
GO_REF:0000024 (PMID:19509288), (PMID:29967381) GO_REF:0000107 GO_REF:0000033
UniProt RGD Ensembl GO_Central
PMID:19509288 PMID:29967381
GO_REF:0000024 GO_REF:0000033 GO_REF:0000107
NCBI chr20:30,378,542...30,399,076
Ensembl chr20:30,378,550...30,399,054
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Dis3
DIS3 homolog, exosome endoribonuclease and 3'-5' exoribonuclease
part_of
ISO IBA
(PMID:20531386) GO_REF:0000033
RGD GO_Central
PMID:20531386
GO_REF:0000033
NCBI chr15:75,820,040...75,850,450
Ensembl chr15:75,823,436...75,850,642
G
Exosc1
exosome component 1
part_of
IBA
GO_REF:0000033
GO_Central
GO_REF:0000033
NCBI chr 1:240,734,777...240,745,431
Ensembl chr 1:240,734,773...240,745,438
G
Exosc10
exosome component 10
part_of
ISO IBA IEA
(PMID:26166824) GO_REF:0000033 GO_REF:0000002
RGD GO_Central InterPro
PMID:26166824
GO_REF:0000002 GO_REF:0000033
NCBI chr 5:158,995,313...159,018,940
Ensembl chr 5:158,995,313...159,018,940
G
Exosc2
exosome component 2
part_of
ISO IBA
(PMID:26166824) GO_REF:0000033
RGD GO_Central
PMID:26166824
GO_REF:0000033
NCBI chr 3:14,962,930...14,973,645
Ensembl chr 3:14,962,917...14,973,575
G
Exosc3
exosome component 3
part_of
ISO IBA
(PMID:11110791) GO_REF:0000033
RGD GO_Central
PMID:11110791
GO_REF:0000033
NCBI chr 5:59,573,849...59,579,065
Ensembl chr 5:59,573,886...59,579,060
G
Exosc4
exosome component 4
part_of
IBA
GO_REF:0000033
GO_Central
GO_REF:0000033
NCBI chr 7:108,047,831...108,050,573
Ensembl chr 7:108,047,831...108,050,573
G
Exosc5
exosome component 5
part_of
IBA
GO_REF:0000033
GO_Central
GO_REF:0000033
NCBI chr 1:81,168,128...81,177,266
Ensembl chr 1:81,166,023...81,177,265
G
Exosc6
exosome component 6
part_of
IBA
GO_REF:0000033
GO_Central
GO_REF:0000033
NCBI chr19:39,022,171...39,023,585
Ensembl chr19:39,022,183...39,023,515
G
Exosc7
exosome component 7
part_of
IBA
GO_REF:0000033
GO_Central
GO_REF:0000033
NCBI chr 8:122,773,607...122,798,943
Ensembl chr 8:122,773,591...122,799,270
G
Exosc8
exosome component 8
part_of
IBA
GO_REF:0000033
GO_Central
GO_REF:0000033
NCBI chr 2:138,930,405...138,937,009
Ensembl chr 2:138,930,405...138,936,928
G
Exosc9
exosome component 9
part_of
ISO IBA
(PMID:22791713) GO_REF:0000033
RGD GO_Central
PMID:22791713
GO_REF:0000033
NCBI chr 2:119,416,028...119,426,981
Ensembl chr 2:119,388,715...119,427,051
G
Mphosph6
M phase phosphoprotein 6
located_in
ISO
(PMID:26166824)
RGD
PMID:26166824
NCBI chr19:45,860,152...45,870,117
Ensembl chr19:45,860,154...45,870,170
G
Mtrex
Mtr4 exosome RNA helicase
located_in
ISO
(PMID:26166824)
RGD
PMID:26166824
NCBI chr 2:44,500,326...44,560,624
Ensembl chr 2:44,461,444...44,560,627
G
Nvl
nuclear VCP-like
located_in
ISO
(PMID:26166824)
RGD
PMID:26166824
NCBI chr13:92,851,023...92,906,749
Ensembl chr13:92,853,650...92,906,049
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Wdr74
WD repeat domain 74
located_in
ISO
(PMID:26456651)
RGD
PMID:26456651
NCBI chr 1:205,631,769...205,636,558
Ensembl chr 1:205,631,824...205,636,563
G
Zfc3h1
zinc finger, C3H1-type containing
part_of
ISO
(PMID:27871484)
RGD
PMID:27871484
NCBI chr 7:51,008,251...51,064,666
Ensembl chr 7:51,007,984...51,064,661
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