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ONTOLOGY REPORT - ANNOTATIONS


Term:exosome (RNase complex)
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Accession:GO:0000178 term browser browse the term
Definition:A ribonuclease complex that has 3-prime to 5-prime exoribonuclease activity and possibly endoribonuclease activity, producing 5-prime-phosphomonoesters. Participates in a multitude of cellular RNA processing and degradation events preventing nuclear export and/or translation of aberrant RNAs. Restricted to processing linear and circular single-stranded RNAs (ssRNA) only. RNAs with complex secondary structures may have to be unwound or pre-processed by co-factors prior to entering the complex, esp if the 3-prime end is structured.
Comment:Note that this term should not be confused with 'exosome' used in the context of vesicles released from multivesicular bodies.
Synonyms:exact_synonym: exosome (ribonucleasease complex);   exosome multienzyme ribonuclease complex



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exosome (RNase complex) term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G C1d C1D nuclear receptor corepressor part_of IBA GO_REF:0000033 GO_Central GO_REF:0000033 NCBI chr14:91,660,951...91,673,177
Ensembl chr14:91,660,989...91,672,852
JBrowse link
G Exosc1 exosome component 1 part_of ISO (PMID:20531389) RGD PMID:20531389 NCBI chr 1:240,734,777...240,745,431
Ensembl chr 1:240,734,773...240,745,438
JBrowse link
G Exosc10 exosome component 10 part_of ISO (PMID:20531389) RGD PMID:20531389 NCBI chr 5:158,995,313...159,018,940
Ensembl chr 5:158,995,313...159,018,940
JBrowse link
G Exosc2 exosome component 2 part_of ISO (PMID:12419256), (PMID:20531389) RGD PMID:12419256 PMID:20531389 NCBI chr 3:14,962,930...14,973,645
Ensembl chr 3:14,962,917...14,973,575
JBrowse link
G Exosc3 exosome component 3 part_of ISO (PMID:20531389) RGD PMID:20531389 NCBI chr 5:59,573,849...59,579,065
Ensembl chr 5:59,573,886...59,579,060
JBrowse link
G Exosc4 exosome component 4 part_of ISO (PMID:20531389) RGD PMID:20531389 NCBI chr 7:108,047,831...108,050,573
Ensembl chr 7:108,047,831...108,050,573
JBrowse link
G Exosc5 exosome component 5 part_of ISO (PMID:20531389) RGD PMID:20531389 NCBI chr 1:81,168,128...81,177,266
Ensembl chr 1:81,166,023...81,177,265
JBrowse link
G Exosc6 exosome component 6 part_of ISO (PMID:20531389) RGD PMID:20531389 NCBI chr19:39,022,171...39,023,585
Ensembl chr19:39,022,183...39,023,515
JBrowse link
G Exosc7 exosome component 7 part_of ISO (PMID:20531389) RGD PMID:20531389 NCBI chr 8:122,773,607...122,798,943
Ensembl chr 8:122,773,591...122,799,270
JBrowse link
G Exosc8 exosome component 8 part_of ISO (PMID:20531389) RGD PMID:20531389 NCBI chr 2:138,930,405...138,937,009
Ensembl chr 2:138,930,405...138,936,928
JBrowse link
G Exosc9 exosome component 9 part_of ISS
IEA
ISO
GO_REF:0000024
GO_REF:0000043
(PMID:20531389)
UniProt
RGD
PMID:20531389 GO_REF:0000024 GO_REF:0000043 NCBI chr 2:119,416,028...119,426,981
Ensembl chr 2:119,388,715...119,427,051
JBrowse link
G Mphosph6 M phase phosphoprotein 6 part_of
located_in
ISO (PMID:20531389)
(PMID:11719186)
RGD PMID:11719186 PMID:20531389 NCBI chr19:45,860,152...45,870,117
Ensembl chr19:45,860,154...45,870,170
JBrowse link
G Mtrex Mtr4 exosome RNA helicase located_in ISO (PMID:11719186) RGD PMID:11719186 NCBI chr 2:44,500,326...44,560,624
Ensembl chr 2:44,461,444...44,560,627
JBrowse link
G Zfc3h1 zinc finger, C3H1-type containing part_of IBA GO_REF:0000033 GO_Central GO_REF:0000033 NCBI chr 7:51,008,251...51,064,666
Ensembl chr 7:51,007,984...51,064,661
JBrowse link
G Zfp36 zinc finger protein 36 part_of
NOT|located_in
IEA
ISS
ISO
GO_REF:0000043
GO_REF:0000024
(PMID:11719186)
UniProt
RGD
PMID:11719186 GO_REF:0000024 GO_REF:0000043 NCBI chr 1:83,669,084...83,671,564
Ensembl chr 1:83,669,084...83,671,564
JBrowse link
cytoplasmic exosome (RNase complex) term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Carhsp1 calcium regulated heat stable protein 1 located_in
part_of
ISS
ISO
GO_REF:0000024
(PMID:21078874)
UniProt
RGD
PMID:21078874 GO_REF:0000024 NCBI chr10:6,946,036...6,960,556
Ensembl chr10:6,946,959...7,020,019
JBrowse link
G Dis3 DIS3 homolog, exosome endoribonuclease and 3'-5' exoribonuclease part_of IBA GO_REF:0000033 GO_Central GO_REF:0000033 NCBI chr15:75,820,040...75,850,450
Ensembl chr15:75,823,436...75,850,642
JBrowse link
G Dis3l DIS3-like exosome 3'-5' exoribonuclease part_of ISO
IBA
ISS
(PMID:20531386), (PMID:20531389)
GO_REF:0000033
GO_REF:0000024
RGD
GO_Central
UniProt
PMID:20531386 PMID:20531389 GO_REF:0000024 GO_REF:0000033 NCBI chr 8:64,803,925...64,840,306
Ensembl chr 8:64,803,927...64,840,165
JBrowse link
G Exosc2 exosome component 2 part_of IBA GO_REF:0000033 GO_Central GO_REF:0000033 NCBI chr 3:14,962,930...14,973,645
Ensembl chr 3:14,962,917...14,973,575
JBrowse link
G Exosc3 exosome component 3 part_of ISO
IBA
(PMID:11110791)
GO_REF:0000033
RGD
GO_Central
PMID:11110791 GO_REF:0000033 NCBI chr 5:59,573,849...59,579,065
Ensembl chr 5:59,573,886...59,579,060
JBrowse link
G Exosc4 exosome component 4 part_of IBA GO_REF:0000033 GO_Central GO_REF:0000033 NCBI chr 7:108,047,831...108,050,573
Ensembl chr 7:108,047,831...108,050,573
JBrowse link
G Exosc5 exosome component 5 part_of IBA GO_REF:0000033 GO_Central GO_REF:0000033 NCBI chr 1:81,168,128...81,177,266
Ensembl chr 1:81,166,023...81,177,265
JBrowse link
G Exosc6 exosome component 6 part_of IBA GO_REF:0000033 GO_Central GO_REF:0000033 NCBI chr19:39,022,171...39,023,585
Ensembl chr19:39,022,183...39,023,515
JBrowse link
G Exosc7 exosome component 7 part_of IBA GO_REF:0000033 GO_Central GO_REF:0000033 NCBI chr 8:122,773,607...122,798,943
Ensembl chr 8:122,773,591...122,799,270
JBrowse link
G Exosc8 exosome component 8 part_of IBA GO_REF:0000033 GO_Central GO_REF:0000033 NCBI chr 2:138,930,405...138,937,009
Ensembl chr 2:138,930,405...138,936,928
JBrowse link
G Exosc9 exosome component 9 part_of IBA GO_REF:0000033 GO_Central GO_REF:0000033 NCBI chr 2:119,416,028...119,426,981
Ensembl chr 2:119,388,715...119,427,051
JBrowse link
G Gtpbp1 GTP binding protein 1 part_of IDA PMID:21515746 UniProt PMID:21515746 RGD:8553842 NCBI chr 7:111,248,254...111,272,705
Ensembl chr 7:111,248,254...111,272,705
JBrowse link
mitochondrial degradosome term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Pnpt1 polyribonucleotide nucleotidyltransferase 1 part_of ISO (PMID:19509288), (PMID:29967381) RGD PMID:19509288 PMID:29967381 NCBI chr14:102,877,553...102,908,696
Ensembl chr14:102,877,553...102,908,696
JBrowse link
G Supv3l1 Suv3 like RNA helicase part_of ISS
ISO
IEA
IBA
GO_REF:0000024
(PMID:19509288), (PMID:29967381)
GO_REF:0000107
GO_REF:0000033
UniProt
RGD
Ensembl
GO_Central
PMID:19509288 PMID:29967381 GO_REF:0000024 GO_REF:0000033 GO_REF:0000107 NCBI chr20:30,378,542...30,399,076
Ensembl chr20:30,378,550...30,399,054
JBrowse link
nuclear exosome (RNase complex) term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Dis3 DIS3 homolog, exosome endoribonuclease and 3'-5' exoribonuclease part_of ISO
IBA
(PMID:20531386)
GO_REF:0000033
RGD
GO_Central
PMID:20531386 GO_REF:0000033 NCBI chr15:75,820,040...75,850,450
Ensembl chr15:75,823,436...75,850,642
JBrowse link
G Exosc1 exosome component 1 part_of IBA GO_REF:0000033 GO_Central GO_REF:0000033 NCBI chr 1:240,734,777...240,745,431
Ensembl chr 1:240,734,773...240,745,438
JBrowse link
G Exosc10 exosome component 10 part_of ISO
IBA
IEA
(PMID:26166824)
GO_REF:0000033
GO_REF:0000002
RGD
GO_Central
InterPro
PMID:26166824 GO_REF:0000002 GO_REF:0000033 NCBI chr 5:158,995,313...159,018,940
Ensembl chr 5:158,995,313...159,018,940
JBrowse link
G Exosc2 exosome component 2 part_of ISO
IBA
(PMID:26166824)
GO_REF:0000033
RGD
GO_Central
PMID:26166824 GO_REF:0000033 NCBI chr 3:14,962,930...14,973,645
Ensembl chr 3:14,962,917...14,973,575
JBrowse link
G Exosc3 exosome component 3 part_of ISO
IBA
(PMID:11110791)
GO_REF:0000033
RGD
GO_Central
PMID:11110791 GO_REF:0000033 NCBI chr 5:59,573,849...59,579,065
Ensembl chr 5:59,573,886...59,579,060
JBrowse link
G Exosc4 exosome component 4 part_of IBA GO_REF:0000033 GO_Central GO_REF:0000033 NCBI chr 7:108,047,831...108,050,573
Ensembl chr 7:108,047,831...108,050,573
JBrowse link
G Exosc5 exosome component 5 part_of IBA GO_REF:0000033 GO_Central GO_REF:0000033 NCBI chr 1:81,168,128...81,177,266
Ensembl chr 1:81,166,023...81,177,265
JBrowse link
G Exosc6 exosome component 6 part_of IBA GO_REF:0000033 GO_Central GO_REF:0000033 NCBI chr19:39,022,171...39,023,585
Ensembl chr19:39,022,183...39,023,515
JBrowse link
G Exosc7 exosome component 7 part_of IBA GO_REF:0000033 GO_Central GO_REF:0000033 NCBI chr 8:122,773,607...122,798,943
Ensembl chr 8:122,773,591...122,799,270
JBrowse link
G Exosc8 exosome component 8 part_of IBA GO_REF:0000033 GO_Central GO_REF:0000033 NCBI chr 2:138,930,405...138,937,009
Ensembl chr 2:138,930,405...138,936,928
JBrowse link
G Exosc9 exosome component 9 part_of ISO
IBA
(PMID:22791713)
GO_REF:0000033
RGD
GO_Central
PMID:22791713 GO_REF:0000033 NCBI chr 2:119,416,028...119,426,981
Ensembl chr 2:119,388,715...119,427,051
JBrowse link
G Mphosph6 M phase phosphoprotein 6 located_in ISO (PMID:26166824) RGD PMID:26166824 NCBI chr19:45,860,152...45,870,117
Ensembl chr19:45,860,154...45,870,170
JBrowse link
G Mtrex Mtr4 exosome RNA helicase located_in ISO (PMID:26166824) RGD PMID:26166824 NCBI chr 2:44,500,326...44,560,624
Ensembl chr 2:44,461,444...44,560,627
JBrowse link
G Nvl nuclear VCP-like located_in ISO (PMID:26166824) RGD PMID:26166824 NCBI chr13:92,851,023...92,906,749
Ensembl chr13:92,853,650...92,906,049
JBrowse link
G Wdr74 WD repeat domain 74 located_in ISO (PMID:26456651) RGD PMID:26456651 NCBI chr 1:205,631,769...205,636,558
Ensembl chr 1:205,631,824...205,636,563
JBrowse link
G Zfc3h1 zinc finger, C3H1-type containing part_of ISO (PMID:27871484) RGD PMID:27871484 NCBI chr 7:51,008,251...51,064,666
Ensembl chr 7:51,007,984...51,064,661
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  cellular_component 20824
    cellular anatomical structure 20625
      intracellular anatomical structure 15180
        exosome (RNase complex) 23
          cytoplasmic exosome (RNase complex) + 14
          nuclear exosome (RNase complex) + 16
Path 2
Term Annotations click to browse term
  cellular_component 20824
    protein-containing complex 6552
      catalytic complex 1858
        exoribonuclease complex 26
          exosome (RNase complex) 23
            cytoplasmic exosome (RNase complex) + 14
            nuclear exosome (RNase complex) + 16
paths to the root