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ONTOLOGY REPORT - ANNOTATIONS

Term:nuclear exosome (RNase complex)
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Accession:GO:0000176 term browser browse the term
Definition:A ribonuclease complex that has 3-prime to 5-prime processive and distributive hydrolytic exoribonuclease activity and endoribonuclease activity, producing 5-prime-phosphomonoesters. Participates in a multitude of cellular RNA processing and degradation events preventing nuclear export and/or translation of aberrant RNAs. Restricted to processing linear and circular single-stranded RNAs (ssRNA) only. RNAs with complex secondary structures may have to be unwound or pre-processed by co-factors prior to entering the complex, esp if the 3-prime end is structured.
Synonyms:exact_synonym: eukaryotic exosome multienzyme ribonuclease complex;   nuclear exosome (ribonuclease complex);   nuclear exosome multienzyme ribonuclease complex


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nuclear exosome (RNase complex) term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Dis3 DIS3 homolog, exosome endoribonuclease and 3'-5' exoribonuclease part_of ISO
IBA
IEA 		(PMID:20531386)
GO_REF:0000033
GO_REF:0000107
GO_REF:0000117 		RGD
GO_Central
Ensembl
UniProt		 PMID:20531386 GO_REF:0000033 GO_REF:0000107 GO_REF:0000117 NCBI chr15:82,231,922...82,258,299
Ensembl chr15:82,231,283...82,258,333 		JBrowse link
G Exosc1 exosome component 1 part_of IBA GO_REF:0000033 GO_Central GO_REF:0000033 NCBI chr 1:250,684,746...250,694,748
Ensembl chr 1:250,684,750...250,694,748 		JBrowse link
G Exosc10 exosome component 10 part_of ISO
IEA
IBA 		(PMID:26166824)
GO_REF:0000002
GO_REF:0000033
GO_REF:0000107 		RGD
InterPro
GO_Central
Ensembl		 PMID:26166824 GO_REF:0000002 GO_REF:0000033 GO_REF:0000107 NCBI chr 5:164,278,414...164,302,067
Ensembl chr 5:164,278,440...164,302,067 		JBrowse link
G Exosc2 exosome component 2 part_of ISO
IBA
IEA 		(PMID:26166824)
GO_REF:0000033
GO_REF:0000107 		RGD
GO_Central
Ensembl		 PMID:26166824 GO_REF:0000033 GO_REF:0000107 NCBI chr 3:35,360,652...35,370,948
Ensembl chr 3:35,360,666...35,371,373 		JBrowse link
G Exosc3 exosome component 3 part_of ISO
IBA
IEA 		(PMID:11110791)
GO_REF:0000033
GO_REF:0000107 		RGD
GO_Central
Ensembl		 PMID:11110791 GO_REF:0000033 GO_REF:0000107 NCBI chr 5:64,369,495...64,374,711
Ensembl chr 5:64,369,495...64,374,902 		JBrowse link
G Exosc4 exosome component 4 part_of IBA GO_REF:0000033 GO_Central GO_REF:0000033 NCBI chr 7:109,928,491...109,931,233
Ensembl chr 7:109,928,498...109,931,820 		JBrowse link
G Exosc5 exosome component 5 part_of IBA GO_REF:0000033 GO_Central GO_REF:0000033 NCBI chr 1:90,295,495...90,305,047
Ensembl chr 1:90,293,797...90,305,046 		JBrowse link
G Exosc6 exosome component 6 part_of IBA GO_REF:0000033 GO_Central GO_REF:0000033 NCBI chr19:55,931,523...55,932,937
Ensembl chr19:55,931,523...55,932,937 		JBrowse link
G Exosc7 exosome component 7 part_of IBA GO_REF:0000033 GO_Central GO_REF:0000033 NCBI chr 8:131,650,988...131,676,399
Ensembl chr 8:131,651,050...131,696,825 		JBrowse link
G Exosc8 exosome component 8 part_of IBA GO_REF:0000033 GO_Central GO_REF:0000033 NCBI chr 2:141,080,568...141,087,112
Ensembl chr 2:141,080,568...141,087,229 		JBrowse link
G Exosc9 exosome component 9 part_of ISO
IBA
IEA 		(PMID:22791713)
GO_REF:0000033
GO_REF:0000107 		RGD
GO_Central
Ensembl		 PMID:22791713 GO_REF:0000033 GO_REF:0000107 NCBI chr 2:121,344,154...121,355,110
Ensembl chr 2:121,344,175...121,374,232 		JBrowse link
G Mphosph6 M phase phosphoprotein 6 located_in ISO (PMID:26166824) RGD PMID:26166824 NCBI chr19:62,768,909...62,778,874
Ensembl chr19:62,768,909...62,778,950 		JBrowse link
G Mtrex Mtr4 exosome RNA helicase located_in ISO
IEA 		(PMID:26166824)
GO_REF:0000107 		RGD
Ensembl		 PMID:26166824 GO_REF:0000107 NCBI chr 2:46,233,528...46,293,827
Ensembl chr 2:46,194,647...46,293,827 		JBrowse link
G Nvl nuclear VCP-like located_in ISO (PMID:26166824) RGD PMID:26166824 NCBI chr13:95,385,389...95,438,490
Ensembl chr13:95,372,641...95,442,291 		JBrowse link
G Wdr74 WD repeat domain 74 located_in ISO
IEA 		(PMID:26456651)
GO_REF:0000107 		RGD
Ensembl		 PMID:26456651 GO_REF:0000107 NCBI chr 1:215,060,901...215,065,687
Ensembl chr 1:215,060,961...215,066,336 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  cellular_component 19485
    protein-containing complex 6265
      nuclear protein-containing complex 1368
        nuclear exosome (RNase complex) 15
          nucleolar exosome (RNase complex) 0
Path 2
Term Annotations click to browse term
  cellular_component 19485
    cellular anatomical structure 19353
      organelle 13686
        membrane-bounded organelle 12471
          intracellular membrane-bounded organelle 11899
            nucleus 7471
              nuclear lumen 4263
                nuclear exosome (RNase complex) 15
                  nucleolar exosome (RNase complex) 0
paths to the root