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EXPERIMENTAL FACTOR ONTOLOGY - ANNOTATIONS

Term:carcinoid heart disease
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Accession:EFO:1001769 term browser browse the term
Definition:Cardiac manifestation of gastrointestinal CARCINOID TUMOR that metastasizes to the liver. Substances secreted by the tumor cells, including SEROTONIN, promote fibrous plaque formation in ENDOCARDIUM and its underlying layers. These deposits cause distortion of the TRICUSPID VALVE and the PULMONARY VALVE eventually leading to STENOSIS and valve regurgitation.
Synonyms:xref: DOID:9005906;   MeSH:D002275;   MedDRA:10069010;   SNOMEDCT:36222008


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  experimental factor 0
    material property 0
      disposition 0
        disease 0
          cardiovascular disease 0
            cardiovascular neoplasm 0
              carcinoid heart disease 0
Path 2
Term Annotations click to browse term
  experimental factor 0
    material property 0
      disposition 0
        disease 0
          cancer or benign tumor 0
            neoplastic disease or syndrome 0
              neoplasm 0
                endocrine neoplasm 0
                  neuroendocrine neoplasm 0
                    carcinoid tumor 0
                      carcinoid heart disease 0
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