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EXPERIMENTAL FACTOR ONTOLOGY - ANNOTATIONS

Term:calcium metabolic disease
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Accession:EFO:0005769 term browser browse the term
Definition:Disorders in the processing of calcium in the body: its absorption, transport, storage, and utilization. Disorders of calcium metabolism occur when the body has too little or too much calcium. The serum level of calcium is closely regulated within a fairly limited range in the human body. In a healthy physiology, extracellular calcium levels are maintained within a tight range through the actions of parathyroid hormone, vitamin D and the calcium sensing receptor.[1] Disorders in calcium metabolism can lead to hypocalcemia, decreased plasma levels of calcium or hypercalcemia, elevated plasma calcium levels.
Comment:Consider relocating this as a sibling of metabolic disease. ; Defined in terms of GO calcium ion homeostatis. Also consistent with HPO. Note advice from GO as calcium ions are neither created or destroyed is not metabolic process in terms of go, but name retained for purposes of consistency with e.g. Snomed and Mesh
Synonyms:exact_synonym: Calcium Metabolism Disorders;   calcium metabolic disorder;   disorder of calcium metabolism
 related_synonym: calcium metabolism disease;   calcium metabolism disorder
 xref: DOID:10575;   ICD9:275.4;   ICD9:275.40;   ICD9:275.49;   ICD9CM:275.4;   ICD9CM:275.40;   MEDGEN:714;   MESH:D002128;   MONDO:0005557;   SCTID:71638002;   SNOMEDCT:190863003;   SNOMEDCT:190874007;   SNOMEDCT:267442002;   SNOMEDCT:71638002;   UMLS:C0006705
 external_ontology: disease_disrupts EFO:GO:0055074;   participates_in EFO:GO:0008152;   participates_in EFO:GO:0055074


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  experimental factor 0
    material property 0
      disposition 0
        disease 0
          metabolic disease 0
            mineral metabolism disease 0
              calcium metabolic disease 0
                autosomal dominant hypocalcemia + 0
                calcinosis + 0
                hypercalcemia disease + 0
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