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EXPERIMENTAL FACTOR ONTOLOGY - ANNOTATIONS

Term:C4BP measurement
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Accession:EFO:0004572 term browser browse the term
Definition:A C4BP measurement is the quantification of C4BP, it controls the classical pathway of complement activation. It binds as a cofactor to C3b/C4b inactivator (C3bINA), which then hydrolyzes the complement fragment C4b. It also accelerates the degradation of the C4bC2a complex (C3 convertase) by dissociating the complement fragment C2a. Alpha chain binds C4b. It interacts also with anticoagulant protein S and with serum amyloid P component. (Uniprot defintion).\nBuil et al, 2010 propose that C4BP may be a susceptibility locus for venous thrombosis based on GWAS and gene expression studies.
Comment:"http://en.wikipedia.org/wiki/C4b-binding_protein"
Synonyms:exact_synonym: C4b binding protein levels;   C4b-binding protein measurement
 external_ontology: is_about is_about EFO:0000319;   is_about EFO:CHEBI:17089


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  experimental factor 0
    information entity 0
      measurement 0
        cardiovascular measurement 0
          cardiovascular disease biomarker measurement 0
            C4BP measurement 0
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