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EXPERIMENTAL FACTOR ONTOLOGY - ANNOTATIONS

Term:obstructive sleep apnea
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Accession:EFO:0003918 term browser browse the term
Definition:A disorder characterized by recurrent apneas during sleep despite persistent respiratory efforts. It is due to upper airway obstruction. The respiratory pauses may induce HYPERCAPNIA or HYPOXIA. Cardiac arrhythmias and elevation of systemic and pulmonary arterial pressures may occur. Frequent partial arousals occur throughout sleep, resulting in relative SLEEP DEPRIVATION and daytime tiredness. Associated conditions include OBESITY; ACROMEGALY; MYXEDEMA; micrognathia; MYOTONIC DYSTROPHY; adenotonsilar dystrophy; and NEUROMUSCULAR DISEASES. (From Adams et al., Principles of Neurology, 6th ed, p395) A disorder characterized by recurrent episodic disruptions of breathing during sleep. It is caused by the intermittent relaxation of pharyngeal muscles leading to the narrowing or complete blockage of the upper airway. This results in compensatory arousal from sleep to breathe again. An anatomically narrow airway from body habitus or enlarged pharyngeal structures may also predispose to obstruction. Clinical presentation usually includes snoring, daytime sleepiness, difficulty concentrating and fatigue. Clinical course may progress to chronic hypoxemia with cardiovascular and cerebrovascular sequelae. Cessation of air flow during sleep due to upper airway obstruction.
Synonyms:exact_synonym: DOID:0050848;   NCIT:C27168;   http://identifiers.org/medgen/101045;   http://identifiers.org/mesh/D020181;   http://identifiers.org/snomedct/78275009;   http://linkedlifedata.com/resource/umls/id/C0520679;   http://purl.bioontology.org/ontology/ICD10CM/G47.33;   https://omim.org/entry/107650
 related_synonym: OSAHS;   Osa;   obstructive sleep Apneas;   sleep apnea hypopnea syndrome;   sleep apnea syndrome, obstructive;   upper airway resistance sleep apnea syndrome
 xref: DOID:0050848;   HP:0002870;   ICD10CM:G47.33;   ICD9:327.23;   ICD9:780.57;   MEDGEN:101045;   MESH:D020181;   MIM:107650;   MONDO:0007147;   NCI:C116337;   NCI:C27168;   NCIm:CL455363;   SCTID:78275009;   SNOMEDCT:78275009;   UMLS:C0520679


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  experimental factor 0
    material property 0
      disposition 0
        disease 0
          syndromic disease 0
            obstructive sleep apnea 0
              complex sleep apnea 0
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  experimental factor 0
    material property 0
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        disease 0
          nervous system disease 0
            central nervous system disease 0
              brain disease 0
                mental or behavioural disorder 0
                  Sleep Disorder 0
                    sleep-wake disorder 0
                      sleep apnea 0
                        obstructive sleep apnea 0
                          complex sleep apnea 0
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