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EXPERIMENTAL FACTOR ONTOLOGY - ANNOTATIONS

Term:primary myelofibrosis
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Accession:EFO:0002430 term browser browse the term
Definition:Myelofibrosis with myeloid metaplasia is a myeloproliferative disease with annual incidence of approximately 1 case per 100,000 individuals and age at diagnosis around 60 (an increased prevalence is noted in Ashkenazi Jews). Clinical manifestations depend on the type of blood cell affected and may include anemia, pallor, splenomegaly, hypermetabolic state, petechiae, ecchymosis, bleeding, lymphadenopathy, hepatomegaly, portal hypertension.
Synonyms:exact_synonym: AMM;   Agnogenic myeloid metaplasia;   CIMF;   aleukemic myelosis;   bone marrow fibrosis;   chronic idiopathic myelofibrosis;   idiopathic bone marrow fibrosis;   idiopathic myelofibrosis;   megakaryocytic myelosclerosis;   myelofibrosis with myeloid metaplasia, somatic;   myelofibrosis, somatic;   myelosclerosis;   myelosclerosis with myeloid metaplasia;   osteomyelofibrosis
 narrow_synonym: myelofibrosis with myeloid metaplasia
 related_synonym: myelofibrosis;   myeloid metaplasia
 xref: COHD:133169;   DOID:4971;   GARD:8618;   ICD10:D47.4;   ICD10:D75.81;   ICD9:238.76;   ICD9:289.83;   ICDO:9961/3;   MEDGEN:7929;   MESH:D055728;   MIM:254450;   MONDO:0009692;   NCI:C2862;   NORD:1611;   ONCOTREE:PMF;   ORDO:824;   UMLS:C0001815;   UMLS:C0948968;   UMLS:C2355576;   icd11.foundation:1407285327;   icd11.foundation:336704235


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  experimental factor 0
    material property 0
      disposition 0
        disease 0
          chronic disease 0
            chronic myeloproliferative disorder 0
              primary myelofibrosis 0
                familial myelofibrosis 0
Path 2
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  experimental factor 0
    material property 0
      disposition 0
        disease 0
          cancer or benign tumor 0
            neoplastic disease or syndrome 0
              neoplasm 0
                cancer 0
                  musculoskeletal system cancer 0
                    Malignant Bone Neoplasm 0
                      bone marrow cancer 0
                        chronic myeloproliferative disorder 0
                          primary myelofibrosis 0
                            familial myelofibrosis 0
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