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EXPERIMENTAL FACTOR ONTOLOGY - ANNOTATIONS

Term:celiac disease
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Accession:EFO:0001060 term browser browse the term
Definition:A food allergy that is caused by a reaction located_in small intestine to gliadin, a prolamin (gluten protein) found in wheat, and similar proteins found in the crops of the tribe Triticeae. The disease is associated with HLA-DQ gene. It has_symptom abdominal pain, has_symptom constipation, has_symptom diarrhea, has_symptom nausea and vomiting, and has_symptom loss of appetite. A food hypersensitivity that is caused by a reaction located_in small intestine to gliadin, a prolamin (gluten protein) found in wheat, and similar proteins found in the crops of the tribe Triticeae. The disease is associated with HLA-DQ gene. It has_symptom abdominal pain, has_symptom constipation, has_symptom diarrhea, has_symptom nausea and vomiting, and has_symptom loss of appetite. A malabsorption syndrome that is precipitated by the ingestion of foods containing GLUTEN, such as wheat, rye, and barley. It is characterized by INFLAMMATION of the SMALL INTESTINE, loss of MICROVILLI structure, failed INTESTINAL ABSORPTION, and MALNUTRITION. A malabsorption syndrome that is precipitated by the ingestion of GLUTEN-containing foods, such as wheat, rye, and barley. It is characterized by INFLAMMATION of the SMALL INTESTINE, loss of MICROVILLI structure, failed INTESTINAL ABSORPTION, and MALNUTRITION. An autoimmune genetic disorder with an unknown pattern of inheritance that primarily affects the digestive tract. It is caused by intolerance to dietary gluten. Consumption of gluten protein triggers an immune response which damages small intestinal villi and prevents adequate absorption of nutrients. Clinical signs include abdominal cramping, diarrhea or constipation and weight loss. If untreated, the clinical course may progress to malnutrition, anemia, osteoporosis and an increased risk of intestinal malignancies. However, the prognosis is favorable with successful avoidance of gluten in the diet.
Synonyms:exact_synonym: CD - Celiac disease;   CD - Coeliac disease;   CELIAC DIS;   CS - Celiac sprue;   CS - Coeliac sprue;   Celiac Sprue;   Celiac disease (disorder);   Celiac disease NOS;   Celiac disease NOS (disorder);   Celiac rickets;   Celiac rickets (disorder);   Celiac syndrome;   Coeliac disease;   Coeliac disease NOS;   Coeliac disease [Ambiguous];   Coeliac rickets;   Coeliac sprue;   Coeliac syndrome;   DOID:10608;   GSE - Gluten-sensitive enteropathy;   Gluten Enteropathies;   Gluten Sensitive Enteropathy;   Gluten enteropathy;   Gluten-Induced Enteropathy;   Gluten-Sensitive Enteropathies;   Gluten-induced enteropathy syndrome;   Gluten-responsive sprue;   Idiopathic steatorrhea;   Idiopathic steatorrhoea;   NCIT:C26714;   Non Tropical Sprue;   Nontropical Sprue;   Sprue;   Wheat-sensitive enteropathy;   gluten intolerance;   http://identifiers.org/medgen/3291;   http://identifiers.org/mesh/D002446;   http://identifiers.org/snomedct/396331005;   http://linkedlifedata.com/resource/umls/id/C0007570;   http://purl.bioontology.org/ontology/ICD10CM/K90.0;   https://omim.org/phenotypicSeries/PS212750
 xref: DOID:10608;   HP:0002608;   ICD10CM:K90.0;   ICD9:579.0;   MEDGEN:3291;   MESH:D002446;   MIM:212750;   MIM:609753;   MIM:609755;   MIM:612011;   MIM:PS212750;   MONDO:0005130;   MedDRA:10007864;   NCI:C26714;   ORDO:555;   SCTID:396331005;   SNOMEDCT:396331005;   UMLS:C0007570
 external_ontology: has_disease_location EFO:UBERON:0002108


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  experimental factor 0
    material property 0
      disposition 0
        disease 0
          genetic disorder 0
            celiac disease 0
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  experimental factor 0
    material property 0
      disposition 0
        disease 0
          digestive system disease 0
            gastrointestinal disease 0
              intestinal disease 0
                malabsorption syndrome 0
                  celiac disease 0
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