Send us a Message
Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   
Search RGD Grant Resources Citing RGD About Us Contact Us
Genes Variants Community Projects QTLs Strains Markers Genome Information Ontologies Cell Lines References Download Submit Data
OntoMate (Literature Search) JBrowse (Genome Browser) Synteny Browser (VCMap) Variant Visualizer Multi-Ontology Enrichment (MOET) Gene-Ortholog Location Finder (GOLF) InterViewer (Protein-Protein Interactions) PhenoMiner (Quatitative Phenotypes) Gene Annotator OLGA (Gene List Generator) AllianceMine GViewer (Genome Viewer)
Aging & Age-Related Disease Cancer & Neoplastic Disease Cardiovascular Disease Coronavirus Disease Developmental Disease Diabetes Hematologic Disease Immune & Inflammatory Disease Infectious Disease Liver Disease Neurological Disease Obesity & Metabolic Syndrome Renal Disease Respiratory Disease Sensory Organ Disease
Find Models Genetic Models Autism Models Rat PhenoMiner (Quantitative Phenotypes) Chinchilla PhenoMiner Expected Ranges (Quantitative Phenotype) PhenoMiner Term Comparison Hybrid Rat Diversity Panel Phenotypes Phenotypes in Other Animal Models Animal Husbandry Strain Medical Records Phylogenetics Strain Availability Calendar Rats 101 Submissions Photo Archive
Pathways
Rat Community Forum Directory of Rat Laboratories Video Tutorials News RGD Publications RGD Presentations Archive Nomenclature Guidelines Resource Links Laboratory Resources Employment Resources
Advanced Search (OLGA)

EXPERIMENTAL FACTOR ONTOLOGY - ANNOTATIONS

Term:hepatocellular carcinoma
go back to main search page
Accession:EFO:0000182 term browser browse the term
Definition:A malignant tumor that arises from hepatocytes. Hepatocellular carcinoma is relatively rare in the United States but very common in all African countries south of the Sahara and in Southeast Asia. Most cases are seen in patients over the age of 50 years, but this tumor can also occur in younger individuals and even in children. Hepatocellular carcinoma is more common in males than females and is associated with hepatitis B, hepatitis C, chronic alcohol abuse and cirrhosis. Serum elevation of alpha-fetoprotein occurs in a large percentage of patients with hepatocellular carcinoma. Grossly, hepatocellular carcinoma may present as a single mass, as multiple nodules, or as diffuse liver involvement. Microscopically, there is a wide range of differentiation from tumor to tumor (well differentiated to poorly differentiated tumors). Hepatocellular carcinomas quickly metastasize to regional lymph nodes and lung. The overall median survival of untreated liver cell carcinoma is about 4 months. The most effective treatment of hepatocellular carcinoma is complete resection of the tumor. Lately, an increasing number of tumors have been treated with liver transplantation.
Synonyms:exact_synonym: DOID:684;   DOID:686;   HCC;   NCIT:C3099;   Orphanet:88673;   carcinoma of liver;   carcinoma of liver cells;   carcinoma of the liver cells;   carcinoma, hepatocellular, malignant;   hepatoblastoma, somatic;   hepatocellular adenocarcinoma;   hepatocellular cancer;   hepatocellular cancer, somatic;   hepatocellular carcinoma, childhood type, somatic;   hepatocellular carcinoma, somatic;   hepatoma;   http://identifiers.org/meddra/10049010;   http://identifiers.org/medgen/389187;   http://identifiers.org/mesh/D006528;   http://identifiers.org/omim/114550;   http://linkedlifedata.com/resource/umls/id/C2239176;   http://purl.obolibrary.org/obo/mondo/sources/icd11foundation/1294035808;   https://omim.org/entry/114550;   liver cell cancer (hepatocellular carcinoma);   liver cell carcinoma;   primary carcinoma of liver cells;   primary carcinoma of the liver cells
 synonym: NCIT:C7711;   http://identifiers.org/mesh/D008113;   http://identifiers.org/snomedct/25370001;   http://linkedlifedata.com/resource/umls/id/C0019204;   http://linkedlifedata.com/resource/umls/id/C2676033
 narrow_synonym: adult hepatoma;   adult primary hepatocellular carcinoma;   liver carcinoma
 related_synonym: hepatoblastoma;   hepatoblastoma caused by somatic mutation;   liver and intrahepatic bile duct carcinoma;   liver cancer
 xref: COHD:4001171;   DOID:684;   DOID:686;   GARD:16773;   HP:0001402;   ICD10:C22.0;   ICDO:8170/3;   MEDGEN:389187;   MESH:D006528;   MIM:114550;   MONDO:0007256;   MedDRA:10007416;   MedDRA:10024658;   MedDRA:10049010;   NANDO:2200047;   NCI:C3099;   NORD:1907;   ONCOTREE:HCC;   ORDO:88673;   UMLS:C2239176;   VT:0010547;   icd11.foundation:1294035808
 external_ontology: has_disease_location EFO:UBERON:0002107


show annotations for term's descendants           Sort by:
Term paths to the root
Path 1
Term Annotations click to browse term
  experimental factor 0
    material property 0
      disposition 0
        disease 0
          digestive system disease 0
            digestive system cancer 0
              liver cancer 0
                carcinoma of liver and intrahepatic biliary tract 0
                  hepatocellular carcinoma 0
                    Fibrolamellar Carcinoma 0
                    Hepatoblastoma 0
                    Liver Diffuse Large B-Cell Lymphoma 0
                    adult hepatocellular carcinoma 0
                    hepatitis virus-related hepatocellular carcinoma + 0
                    hepatocellular clear cell carcinoma 0
                    pediatric hepatocellular carcinoma 0
Path 2
Term Annotations click to browse term
  experimental factor 0
    material property 0
      disposition 0
        disease 0
          cancer or benign tumor 0
            neoplastic disease or syndrome 0
              neoplasm 0
                digestive system neoplasm 0
                  Hepatobiliary Neoplasm 0
                    liver and intrahepatic bile duct neoplasm 0
                      liver cancer 0
                        carcinoma of liver and intrahepatic biliary tract 0
                          hepatocellular carcinoma 0
                            Fibrolamellar Carcinoma 0
                            Hepatoblastoma 0
                            Liver Diffuse Large B-Cell Lymphoma 0
                            adult hepatocellular carcinoma 0
                            hepatitis virus-related hepatocellular carcinoma + 0
                            hepatocellular clear cell carcinoma 0
                            pediatric hepatocellular carcinoma 0
paths to the root