neoplasm of mature B-cells - Ontology Report

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Term:	neoplasm of mature B-cells	go back to main search page
Accession:	EFO:0000096	browse the term
Definition:	A neoplasm of follicle center B cells which has at least a partial follicular pattern. Follicular lymphomas comprise about 35% of adult non-Hodgkin lymphomas in the U.S. and 22% worldwide. Most patients have widespread disease at diagnosis. Morphologically, follicular lymphomas are classified as Grade 1, Grade 2, and Grade 3, depending on the percentage of the large lymphocytes present. The vast majority of cases (70-95%) express the BCL-2 rearrangement [t(14;18)]. Histological grade correlates with prognosis. Grades 1 and 2 follicular lymphomas are indolent and grade 3 is more aggressive (adapted from WHO, 2001).
Comment:	Editor note: is a non-hodgkin in ONCOTREE
Synonyms:	exact_synonym:	mature B-cell lymphocytic neoplasm; mature B-cell neoplasm
	related_synonym:	mature B-cell neoplasms
	xref:	DOID:706; ICD9:202.0; MEDGEN:235305; MONDO:0004949; NCI:C27910; NCI:C3457; ONCOTREE:MBN; SCTID:269476000; UMLS:C1334633; VT:0010898

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Term paths to the root

Path 1
Term	Annotations
experimental factor	0
material property	0
disposition	0
disease	0
immune system disease	0
leukocyte disorder	0
B-cell neoplasm	0
neoplasm of mature B-cells	0
B-Cell Prolymphocytic Leukemia	0
Burkitts lymphoma +	0
Central Nervous System Lymphoma +	0
MALT lymphoma +	0
chronic lymphocytic leukemia +	0
diffuse large B-cell lymphoma +	0
follicular lymphoma	0
plasma cell neoplasm +	0
Path 2
Term	Annotations
experimental factor	0
material property	0
disposition	0
disease	0
cancer or benign tumor	0
neoplastic disease or syndrome	0
neoplasm	0
hematopoietic and lymphoid system neoplasm	0
hematopoietic and lymphoid cell neoplasm	0
lymphoid neoplasm	0
lymphoma	0
B-cell neoplasm	0
neoplasm of mature B-cells	0
B-Cell Prolymphocytic Leukemia	0
Burkitts lymphoma +	0
Central Nervous System Lymphoma +	0
MALT lymphoma +	0
chronic lymphocytic leukemia +	0
diffuse large B-cell lymphoma +	0
follicular lymphoma	0
plasma cell neoplasm +	0

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