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RGD DISEASE ONTOLOGY - ANNOTATIONS

RGD uses the Human Disease Ontology (DO, https://disease-ontology.org/) for disease curation across species. RGD automatically downloads each new release of the ontology on a monthly basis. Some additional terms which are required for RGD's curation purposes but are not currently covered in the official version of DO have been added. As corresponding terms are added to DO, these custom terms are retired and the DO terms substituted in existing annotations and subsequently used for curation.
Term:neonatal abstinence syndrome
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Accession:DOID:9828 term browser browse the term
Definition:A withdrawal disorder that is characterized by a group of problems that occur in a newborn who was exposed to addictive illegal or prescription drugs while in the mother's womb or postnatally following the discontinuance of drug treatment. (DO)
Synonyms:exact_synonym: Neonatal Abstinence Syndromes;   Neonatal Passive Addiction;   Neonatal Passive Addictions;   Neonatal Substance Withdrawal;   Neonatal Substance Withdrawals;   Neonatal Withdrawal Syndrome;   Neonatal Withdrawal Syndromes;   drug withdrawal syndrome in newborn
 primary_id: MESH:D009357
 xref: EFO:0005799;   ICD10CM:P96.1;   ICD9CM:779.5;   NCI:C35808;   NCI:C87101


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neonatal abstinence syndrome term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Comt catechol-O-methyltransferase treatment
ameliorates		 ISO DNA:SNPs:cds: (rs4680,rs750603) c.158A>G (human)
DNA:SNP: 158A>G (rs4680) (human)
associated with maternal opioid abuse;DNA:SNP:intron (rs740603) (human)		 RGD PMID:27983768 PMID:23632726 PMID:26233486 RGD:401950496, RGD:11097592, RGD:11079504 NCBI chr11:82,568,052...82,587,642
Ensembl chr11:82,568,025...82,587,642 		JBrowse link
G Cyp2b3 cytochrome P450, family 2, subfamily b, polypeptide 3 treatment ISO DNA:SNP: :CYP2B6*6 (516G>T,785A>G) ((human) RGD PMID:28320034 RGD:401901176 NCBI chr 1:81,652,762...81,732,153
Ensembl chr 1:81,652,787...81,732,143 		JBrowse link
G Grin2a glutamate ionotropic receptor NMDA type subunit 2A ISO mRNA:decreased expression:placenta RGD PMID:34352367 RGD:401938659 NCBI chr10:5,629,683...6,053,262
Ensembl chr10:5,631,369...6,044,637 		JBrowse link
G Oprk1 opioid receptor, kappa 1 severity ISO associated with maternal opioid abuse;DNA:SNP:intron (rs702764) (human) RGD PMID:26233486 RGD:11079504 NCBI chr 5:13,860,016...13,877,823
Ensembl chr 5:13,860,021...13,877,823 		JBrowse link
G Oprm1 opioid receptor, mu 1 treatment
ameliorates		 ISO DNA:SNP: 118A>G (rs1799971) (human)
associated with maternal opioid abuse;DNA:SNP:intron (rs1799971) (human)		 RGD PMID:23632726 PMID:26233486 RGD:11097592, RGD:11079504 NCBI chr 1:43,160,057...43,413,409
Ensembl chr 1:43,160,057...43,413,409 		JBrowse link
G Pnoc prepronociceptin severity ISO associated with maternal opioid abuse;DNA:SNP:intron (rs732636|rs351776|rs2614095 ) (human) RGD PMID:26233486 RGD:11079504 NCBI chr15:39,624,635...39,652,463
Ensembl chr15:39,624,641...39,651,867 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  disease 19137
    syndrome 11372
      neonatal abstinence syndrome 6
Path 2
Term Annotations click to browse term
  disease 19137
    disease of anatomical entity 18450
      nervous system disease 14357
        central nervous system disease 12630
          brain disease 11847
            disease of mental health 8443
              substance-related disorder 758
                withdrawal disorder 105
                  neonatal abstinence syndrome 6
paths to the root