|
G |
Adipoq |
adiponectin, C1Q and collagen domain containing |
|
ISO |
|
RGD |
PMID:20935231 |
RGD:5686887 |
NCBI chr11:91,226,524...91,240,244
|
|
G |
Ager |
advanced glycosylation end product-specific receptor |
|
ISO |
CTD Direct Evidence: marker/mechanism |
CTD |
PMID:30659203 |
|
NCBI chr20:4,152,758...4,155,956
|
|
G |
Alb |
albumin |
|
ISO |
|
RGD |
PMID:24365562 |
RGD:11035274 |
NCBI chr14:17,891,564...17,907,043
|
|
G |
Bloc1s6 |
biogenesis of lysosomal organelles complex 1 subunit 6 |
|
ISS |
OMIM:130700 |
MouseDO |
|
|
NCBI chr 3:109,816,397...109,826,528
|
|
G |
Ccl11 |
C-C motif chemokine ligand 11 |
disease_progression |
ISO |
associated with Pulmonary Disease, Chronic Obstructive;protein:increased expression:lung |
RGD |
PMID:17983873 |
RGD:4145393 |
NCBI chr10:67,525,975...67,530,576
|
|
G |
Ccl2 |
C-C motif chemokine ligand 2 |
disease_progression |
ISO |
associated with Pulmonary Disease, Chronic Obstructive;protein:increased expression:sputum |
RGD |
PMID:20966041 |
RGD:4891458 |
NCBI chr10:67,503,077...67,504,875
|
|
G |
Ccr5 |
C-C motif chemokine receptor 5 |
|
ISO |
mRNA, protein:increased expression:lung (mouse) protein:increased expression:lung, lymphocyte (human) |
RGD |
PMID:16284650 PMID:15526056 PMID:17883726 |
RGD:4892098, RGD:4892104, RGD:4892090 |
NCBI chr 8:132,629,097...132,660,980
|
|
G |
Chi3l1 |
chitinase 3 like 1 |
|
ISO |
|
RGD |
PMID:20656949 |
RGD:4892658 |
NCBI chr13:45,641,802...45,649,787
|
|
G |
Clptm1l |
CLPTM1-like |
severity |
ISO |
associated with smoking; DNA:SNP:intron:rs31489(human) |
RGD |
PMID:21622582 |
RGD:150530642 |
NCBI chr 1:29,667,545...29,683,530
|
|
G |
Csf3 |
colony stimulating factor 3 |
treatment |
ISO |
|
RGD |
PMID:19537526 |
RGD:11039438 |
NCBI chr10:84,157,485...84,159,860
|
|
G |
Cx3cl1 |
C-X3-C motif chemokine ligand 1 |
|
ISO |
|
RGD |
PMID:18772344 |
RGD:4891888 |
NCBI chr19:10,233,326...10,244,856
|
|
G |
Cxcl1 |
C-X-C motif chemokine ligand 1 |
|
ISO |
mRNA:increased expression:lung |
RGD |
PMID:17023518 |
RGD:5135245 |
NCBI chr14:17,477,542...17,479,321
|
|
G |
Cxcl10 |
C-X-C motif chemokine ligand 10 |
|
ISO |
protein:increased expression:lung, lymphocyte |
RGD |
PMID:15526056 |
RGD:4892104 |
NCBI chr14:15,989,066...15,991,263
|
|
G |
Cxcl3 |
C-X-C motif chemokine ligand 3 |
|
ISO |
mRNA:increased expression:lung |
RGD |
PMID:17023518 |
RGD:5135245 |
NCBI chr14:17,571,900...17,573,624
|
|
G |
Cxcl6 |
C-X-C motif chemokine ligand 6 |
|
ISO |
mRNA:increased expression:lung |
RGD |
PMID:17023518 |
RGD:5135245 |
NCBI chr14:17,310,790...17,312,250
|
|
G |
Cxcl9 |
C-X-C motif chemokine ligand 9 |
|
ISO |
protein:increased expression:lung, lymphocyte |
RGD |
PMID:15526056 |
RGD:4892104 |
NCBI chr14:16,007,166...16,012,077
|
|
G |
Cxcr3 |
C-X-C motif chemokine receptor 3 |
|
ISO |
|
RGD |
PMID:15526056 |
RGD:4892104 |
NCBI chr X:66,844,318...66,846,969
|
|
G |
Defb1 |
defensin beta 1 |
|
ISO |
mRNA:decreased expression:lung |
RGD |
PMID:18699806 |
RGD:4892249 |
NCBI chr16:70,298,862...70,313,604
|
|
G |
Ednra |
endothelin receptor type A |
|
IMP |
|
RGD |
PMID:19897563 |
RGD:4892307 |
NCBI chr19:47,137,360...47,207,961
|
|
G |
Egr1 |
early growth response 1 |
resistance |
ISO |
mRNA, protein:increased expression:lung (human) associated with Tobacco Use Disorder;protein:increased expression:lung, epithelial cell (mouse) |
RGD |
PMID:11021835 PMID:16601242 PMID:18830406 |
RGD:5131973, RGD:5131892, RGD:5131853 |
NCBI chr18:26,737,078...26,740,877
|
|
G |
Elane |
elastase, neutrophil expressed |
|
IMP |
|
RGD |
PMID:12186827 |
RGD:10450557 |
NCBI chr 7:9,817,251...9,819,174
|
|
G |
Eln |
elastin |
|
ISO |
CTD Direct Evidence: marker/mechanism |
CTD |
PMID:25106431 |
|
NCBI chr12:27,604,983...27,648,413
|
|
G |
Ephx1 |
epoxide hydrolase 1 |
no_association susceptibility |
ISO |
associated with Pulmonary Disease, Chronic Obstructive;DNA:SNPs (human) DNA:SNPs:exons:p.Y113H (rs1051740), p.H139R (rs2234922) (human) DNA:SNP:exon:p.Y113H (rs1051740) (human) CTD Direct Evidence: marker/mechanism |
CTD RGD |
PMID:9288046 PMID:20525719 PMID:10853854 PMID:9288046 PMID:12579334 |
RGD:4140935, RGD:4889406, RGD:1601065, RGD:4889405 |
NCBI chr13:95,246,079...95,275,852
|
|
G |
Fga |
fibrinogen alpha chain |
|
IEP |
protein:increased expression:plasma (rat) |
RGD |
PMID:20949089 |
RGD:11040553 |
NCBI chr 2:170,672,169...170,679,572
|
|
G |
Fstl1 |
follistatin-like 1 |
|
ISS |
OMIM:130700 |
MouseDO |
|
|
NCBI chr11:62,895,391...62,948,581
|
|
G |
Fut8 |
fucosyltransferase 8 |
|
ISS |
OMIM:130700 |
MouseDO |
|
|
NCBI chr 6:95,949,246...96,176,677
|
|
G |
Gclc |
glutamate-cysteine ligase, catalytic subunit |
|
IDA |
|
RGD |
PMID:19879314 |
RGD:5134681 |
NCBI chr 8:87,510,251...87,548,896
|
|
G |
Gstm1 |
glutathione S-transferase mu 1 |
susceptibility |
ISO |
DNA:deletion: : |
RGD |
PMID:20495862 |
RGD:4140927 |
NCBI chr 2:198,338,005...198,346,007
|
|
G |
Gstm3 |
glutathione S-transferase mu 3 |
|
ISO |
|
RGD |
PMID:19723343 |
RGD:5135041 |
NCBI chr 2:195,590,450...195,612,578
|
|
G |
Gstm5 |
glutathione S-transferase, mu 5 |
|
ISO |
|
RGD |
PMID:19723343 |
RGD:5135041 |
NCBI chr 2:195,531,599...195,534,562
|
|
G |
Gstp1 |
glutathione S-transferase pi 1 |
|
ISO |
associated with Pulmonary Disease, Chronic Obstructive;DNA:SNP (human) |
RGD |
PMID:20525719 |
RGD:4140935 |
NCBI chr 1:210,767,237...210,770,242
|
|
G |
Hdac2 |
histone deacetylase 2 |
treatment |
IEP ISO |
mRNA,proetin:increased expression,increased activity,hyperphosphorylation,hypercarbonylation:lung: |
RGD |
PMID:23326540 PMID:24040961 |
RGD:9590245, RGD:9590320 |
NCBI chr20:42,101,815...42,126,486
|
|
G |
Hhip |
Hedgehog-interacting protein |
|
ISO |
DNA:haplotype insufficiency: : |
RGD |
PMID:25763110 |
RGD:11552596 |
NCBI chr19:27,863,684...27,952,528
|
|
G |
Hmox1 |
heme oxygenase 1 |
susceptibility |
ISO |
CTD Direct Evidence: marker/mechanism |
CTD RGD |
PMID:10631150 PMID:10631150 |
RGD:1601606 |
NCBI chr19:13,452,365...13,479,823
|
|
G |
Il13 |
interleukin 13 |
|
ISO |
|
RGD |
PMID:11067861 |
RGD:4145652 |
NCBI chr10:38,290,926...38,293,483
|
|
G |
Il17ra |
interleukin 17 receptor A |
|
ISO |
|
RGD |
PMID:21647421 |
RGD:5144212 |
NCBI chr 4:153,667,534...153,690,174
|
|
G |
Il18 |
interleukin 18 |
|
ISO IEP |
mRNA, protein:increased expression:respiratory system fluid/secretion, macrophage |
RGD |
PMID:17400729 PMID:23392573 |
RGD:4889590, RGD:8655969 |
NCBI chr 8:59,802,072...59,829,275
|
|
G |
Il1rl1 |
interleukin 1 receptor-like 1 |
treatment |
ISO |
associated with common cold; |
RGD |
PMID:30952808 |
RGD:40400740 |
NCBI chr 9:42,661,694...42,727,266
|
|
G |
Itgb6 |
integrin subunit beta 6 |
|
ISO ISS |
CTD Direct Evidence: marker/mechanism OMIM:130700 |
CTD MouseDO RGD |
PMID:12634787 PMID:12634787 |
RGD:737734 |
NCBI chr 3:45,046,295...45,170,532
|
|
G |
Jun |
Jun proto-oncogene, AP-1 transcription factor subunit |
|
ISS |
OMIM:130700 |
MouseDO |
|
|
NCBI chr 5:115,009,900...115,012,993
|
|
G |
Keap1 |
Kelch-like ECH-associated protein 1 |
onset |
ISO |
protein:increased expression:lung (human) |
RGD |
PMID:18559366 PMID:19520915 |
RGD:5134973, RGD:6893395 |
NCBI chr 8:19,768,375...19,777,862
|
|
G |
Kl |
Klotho |
|
ISS |
OMIM:130700 |
MouseDO |
|
|
NCBI chr12:490,402...531,417
|
|
G |
Lox |
lysyl oxidase |
|
ISO |
ClinVar Annotator: match by term: Pulmonary emphysema |
ClinVar |
PMID:25741868 PMID:28492532 |
|
NCBI chr18:45,964,544...45,977,431
|
|
G |
Mmp1 |
matrix metallopeptidase 1 |
|
ISO |
DNA:insertion:promoter:g.-1607insG rs1799750 (human) |
RGD |
PMID:17363767 |
RGD:4890375 |
NCBI chr 8:12,943,453...12,963,966
|
|
G |
Mmp12 |
matrix metallopeptidase 12 |
|
ISO |
CTD Direct Evidence: marker/mechanism |
CTD |
PMID:12634787 PMID:25106431 |
|
NCBI chr 8:4,581,785...4,591,687
|
|
G |
Mmp2 |
matrix metallopeptidase 2 |
|
IEP ISO |
protein:increased activity:lung CTD Direct Evidence: marker/mechanism |
CTD RGD |
PMID:25106431 PMID:19897563 |
RGD:4892307 |
NCBI chr19:30,327,643...30,355,856
|
|
G |
Mmp9 |
matrix metallopeptidase 9 |
treatment |
IEP ISO |
protein:increased activity:lung CTD Direct Evidence: marker/mechanism |
CTD RGD |
PMID:25106431 PMID:19897563 PMID:18408070 PMID:14605041 |
RGD:4892307, RGD:5130151, RGD:8547887 |
NCBI chr 3:174,103,474...174,111,434
|
|
G |
Mus81 |
MUS81 structure-specific endonuclease subunit |
|
ISS |
OMIM:130700 |
MouseDO |
|
|
NCBI chr 1:202,790,295...202,796,008
|
|
G |
Nfe2l2 |
NFE2 like bZIP transcription factor 2 |
|
ISO |
protein:decreased expression:lung: |
RGD |
PMID:18559366 |
RGD:5134973 |
NCBI chr 3:81,001,529...81,031,165
|
|
G |
Nfkbia |
NFKB inhibitor alpha |
treatment |
IDA |
|
RGD |
PMID:20472710 |
RGD:4891488 |
NCBI chr 6:78,593,844...78,597,307
|
|
G |
Nos2 |
nitric oxide synthase 2 |
|
IEP ISO |
protein:increased expression:lung mRNA,protein:increased expression:lung |
RGD |
PMID:20472710 PMID:20956973 PMID:22000010 |
RGD:4891488, RGD:4891415, RGD:5509103 |
NCBI chr10:64,313,335...64,349,221
|
|
G |
Nos3 |
nitric oxide synthase 3 |
|
ISO |
mRNA,protein:increased expression:lung |
RGD |
PMID:20956973 |
RGD:4891415 |
NCBI chr 4:11,686,088...11,706,604
|
|
G |
Nqo1 |
NAD(P)H quinone dehydrogenase 1 |
|
ISO |
mRNA:decreased expression:lung |
RGD |
PMID:18559366 |
RGD:5134973 |
NCBI chr19:52,205,374...52,220,267
|
|
G |
Pgf |
placental growth factor |
|
ISO |
mRNA, protein:increased expression:lung, plasma |
RGD |
PMID:17023518 |
RGD:5135245 |
NCBI chr 6:110,547,165...110,557,747
|
|
G |
Ppargc1a |
PPARG coactivator 1 alpha |
|
ISO |
|
RGD |
PMID:23144332 |
RGD:7242020 |
NCBI chr14:63,073,505...63,729,215
|
|
G |
Ptgs2 |
prostaglandin-endoperoxide synthase 2 |
|
IMP |
|
RGD |
PMID:20472710 |
RGD:4891488 |
NCBI chr13:64,714,063...64,722,320
|
|
G |
Ptma |
prothymosin alpha |
|
ISS |
OMIM:130700 |
MouseDO |
|
|
NCBI chr 9:94,624,194...94,628,276
|
|
G |
Scnn1b |
sodium channel epithelial 1 subunit beta |
|
ISO |
CTD Direct Evidence: marker/mechanism |
CTD |
PMID:27982104 |
|
NCBI chr 1:185,861,326...185,915,717
|
|
G |
Serpina1 |
serpin family A member 1 |
|
ISO |
CTD Direct Evidence: marker/mechanism |
CTD RGD |
PMID:3485249 PMID:21030517 PMID:19941265 |
RGD:4892126, RGD:4892125 |
NCBI chr 6:128,631,101...128,653,125
|
|
G |
Sftpc |
surfactant protein C |
susceptibility |
ISO |
DNA:polymorphism: :138A>C, 186A>G (human) |
RGD |
PMID:18038590 |
RGD:4144115 |
NCBI chr15:45,596,565...45,599,615
|
|
G |
Smo |
smoothened, frizzled class receptor |
|
ISS |
OMIM:130700 |
MouseDO |
|
|
NCBI chr 4:59,311,084...59,341,280
|
|
G |
Smpd3 |
sphingomyelin phosphodiesterase 3 |
|
ISO |
protein:increased expression:lung: |
RGD |
PMID:20448054 |
RGD:10041059 |
NCBI chr19:34,162,337...34,245,786
|
|
G |
Srfbp1 |
serum response factor binding protein 1 |
|
ISO |
ClinVar Annotator: match by term: Pulmonary emphysema |
ClinVar |
PMID:25741868 PMID:28492532 |
|
NCBI chr18:45,920,389...45,945,385
|
|
G |
Tacr1 |
tachykinin receptor 1 |
|
ISO |
|
RGD |
PMID:19445658 |
RGD:5147818 |
NCBI chr 4:116,478,617...116,647,492
|
|
G |
Tgfb1 |
transforming growth factor, beta 1 |
severity |
ISO |
associated with Pulmonary Disease, Chronic Obstructive;DNA:SNPs:promoter:rs1800469, rs1982073 (human) CTD Direct Evidence: therapeutic |
CTD RGD |
PMID:12634787 PMID:18670143 |
RGD:4145272 |
NCBI chr 1:90,324,312...90,340,627
|
|
G |
Tlr2 |
toll-like receptor 2 |
|
ISO |
protein:increased expression:alveolar macrophage |
RGD |
PMID:18399852 |
RGD:4145342 |
NCBI chr 2:171,499,189...171,504,831
|
|
G |
Tlr4 |
toll-like receptor 4 |
|
ISO ISS |
OMIM:130700 |
MouseDO RGD |
PMID:17053835 |
RGD:4144170 |
NCBI chr 5:85,161,247...85,174,882
|
|
G |
Tnf |
tumor necrosis factor |
|
ISO |
CTD Direct Evidence: marker/mechanism |
CTD |
PMID:25106431 |
|
NCBI chr20:3,626,685...3,629,303
|
|