Send us a Message
Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   
Search RGD Grant Resources Citing RGD About Us Contact Us
Genes Variants Community Projects QTLs Strains Markers Genome Information Ontologies Cell Lines References Download Submit Data
OntoMate (Literature Search) JBrowse (Genome Browser) Synteny Browser (VCMap) Variant Visualizer Multi-Ontology Enrichment (MOET) Gene-Ortholog Location Finder (GOLF) InterViewer (Protein-Protein Interactions) PhenoMiner (Quatitative Phenotypes) Gene Annotator OLGA (Gene List Generator) AllianceMine GViewer (Genome Viewer)
Aging & Age-Related Disease Cancer & Neoplastic Disease Cardiovascular Disease Coronavirus Disease Developmental Disease Diabetes Hematologic Disease Immune & Inflammatory Disease Infectious Disease Liver Disease Neurological Disease Obesity & Metabolic Syndrome Renal Disease Respiratory Disease Sensory Organ Disease
Find Models Genetic Models Autism Models Rat PhenoMiner (Quantitative Phenotypes) Chinchilla PhenoMiner Expected Ranges (Quantitative Phenotype) PhenoMiner Term Comparison Hybrid Rat Diversity Panel Phenotypes Phenotypes in Other Animal Models Animal Husbandry Strain Medical Records Phylogenetics Strain Availability Calendar Rats 101 Submissions Photo Archive
Pathways
Rat Community Forum Directory of Rat Laboratories Video Tutorials News RGD Publications RGD Presentations Archive Nomenclature Guidelines Resource Links Laboratory Resources Employment Resources
Advanced Search (OLGA)

RGD DISEASE ONTOLOGY - ANNOTATIONS

RGD uses the Human Disease Ontology (DO, https://disease-ontology.org/) for disease curation across species. RGD automatically downloads each new release of the ontology on a monthly basis. Some additional terms which are required for RGD's curation purposes but are not currently covered in the official version of DO have been added. As corresponding terms are added to DO, these custom terms are retired and the DO terms substituted in existing annotations and subsequently used for curation.
Term:type 2 diabetes mellitus
go back to main search page
Accession:DOID:9352 term browser browse the term
Definition:A diabetes mellitus that is characterized by high blood sugar, insulin resistance, and relative lack of insulin. (DO)
Synonyms:exact_synonym: Diabetes Mellitus, Type II;   Diabetes mellitus with hyperinsulinemia;   IRS1-RELATED CONDITION;   IRS2-RELATED CONDITION;   Ketosis-Resistant Diabetes Mellitus;   MTNR1B-RELATED CONDITION;   Maturity Onset Diabetes Mellitus;   Maturity-Onset Diabetes;   NIDDM;   Non-Insulin-Dependent Diabetes Mellitus;   PPP1R3A-RELATED CONDITION;   SLC30A8-RELATED CONDITION;   T2D;   TCF7L2-RELATED CONDITION;   adult-onset diabetes mellitus;   diabetes mellitus, noninsulin-dependent, late-onset;   insulin-resistant diabetes mellitus;   noninsulin-dependent diabetes mellitus;   slow-onset diabetes mellitus;   stable diabetes mellitus;   type 2 diabetes
 narrow_synonym: DIABETES MELLITUS, NONINSULIN-DEPENDENT, MATERNALLY TRANSMITTED;   DIABETES MELLITUS, NONINSULIN-DEPENDENT, WITH ACANTHOSIS NIGRICANS AND HYPERTENSION;   DIABETES MELLITUS, TYPE II, DIGENIC;   INSULIN RESISTANCE, SEVERE, DIGENIC;   PTPN1-RELATED CONDITION
 related_synonym: DIABETES MELLITUS TYPE 2, SUSCEPTIBILITY TO;   DIABETES MELLITUS, TYPE II, SUSCEPTIBILITY TO;   FABP2 POLYMORPHISM;   GPD2-RELATED CONDITION;   HYPERTENSION, INSULIN RESISTANCE-RELATED, SUSCEPTIBILITY TO;   MATURITY-ONSET DIABETES INSULIN RESISTANCE, SUSCEPTIBILITY TO;   NEUROD1-RELATED CONDITION;   UCP3 polymorphism G/A;   diabetes mellitus type 2, protection against;   noninsulin-dependent diabetes mellitus, association with
 xref: EFO:0001360;   EFO:0010164;   ICD10CM:E11;   MESH:D003924;   MIM:125853;   MONDO:0005148;   NCI:C26747


show annotations for term's descendants           Sort by:
type 2 diabetes mellitus term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Aanat aralkylamine N-acetyltransferase IDA mRNA, protein:increased expression, decreased activity:pineal gland RGD PMID:16441550 RGD:2301037 NCBI chr10:102,323,647...102,330,639
Ensembl chr10:101,827,301...101,831,801 		JBrowse link
G Abca1 ATP binding cassette subfamily A member 1 onset ISO DNA:SNP:exon:p.R230C (rs9282541) (human) RGD PMID:18003760 RGD:2312576 NCBI chr 5:72,473,676...72,596,563
Ensembl chr 5:67,681,297...67,801,170 		JBrowse link
G Abcb1a ATP binding cassette subfamily B member 1A ISO DNA:polymorphism:exon (human) RGD PMID:19470683 RGD:2312331 NCBI chr 4:26,312,403...26,488,456
Ensembl chr 4:25,158,362...25,442,709 		JBrowse link
G Abcc2 ATP binding cassette subfamily C member 2 IEP
ISO		 mRNA: decreased expression: liver
protein: increased expression
mRNA:decreased expression:liver		 RGD PMID:15319330 PMID:18189363 PMID:25152023 RGD:2312736, RGD:2312726, RGD:14700811 NCBI chr 1:252,613,875...252,672,459
Ensembl chr 1:242,664,657...242,723,238 		JBrowse link
G Abcc8 ATP binding cassette subfamily C member 8 susceptibility ISO DNA:missense mutations: :p.R248Q, p.K1521N, p.Y356C (human)
DNA:missense mutation::A1369S (human)
DNA:polymorphism:exon:
DNA:polymorphism:intron:IVS16-3T>C (human)
DNA:polymorphism: :p.S1369A (human)
CTD Direct Evidence: marker/mechanism
ClinVar Annotator: match by term: Type 2 diabetes mellitus
ClinVar Annotator: match by term: Diabetes mellitus type 2, susceptibility to | ClinVar Annotator: match by term: Type 2 diabetes mellitus
ClinVar Annotator: match by term: Diabetes Mellitus, Noninsulin-Dependent, with Acanthosis Nigricans and Hypertension | ClinVar Annotator: match by term: Type 2 diabetes mellitus | ClinVar Annotator: match by term: Type II diabetes mellitus
ClinVar Annotator: match by term: Diabetes mellitus, noninsulin-dependent, late onset | ClinVar Annotator: match by term: Type 2 diabetes mellitus | ClinVar Annotator: match by term: Type II diabetes mellitus		 OMIM
CTD
ClinVar
RGD		 PMID:1021286 PMID:3202066 PMID:7716548 PMID:7908292 PMID:8650576 More... RGD:2301901, RGD:1598640, RGD:2313628, RGD:737749, RGD:2301897, RGD:2301898 NCBI chr 1:105,734,992...105,816,272
Ensembl chr 1:96,598,647...96,679,510 		JBrowse link
G Abcg2 ATP binding cassette subfamily G member 2 IEP mRNA:decreased expression:liver RGD PMID:25152023 RGD:14700811 NCBI chr 4:89,006,056...89,132,915
Ensembl chr 4:87,745,319...87,802,409 		JBrowse link
G Acads acyl-CoA dehydrogenase short chain ISO ClinVar Annotator: match by term: Type 2 diabetes mellitus ClinVar PMID:18523805 PMID:25741868 PMID:28492532 NCBI chr12:47,154,259...47,163,580
Ensembl chr12:41,493,626...41,502,898 		JBrowse link
G Ace angiotensin I converting enzyme susceptibility ISO DNA:deletion:intron:IVS16+1464-1751del (human) GAD
RGD		 PMID:15118671 PMID:24452036 RGD:1331525, RGD:8142353 NCBI chr10:91,410,129...91,430,246
Ensembl chr10:90,910,316...90,931,131 		JBrowse link
G Acot2 acyl-CoA thioesterase 2 IDA RGD PMID:16979414 RGD:1625728 NCBI chr 6:109,341,426...109,352,818
Ensembl chr 6:103,611,544...103,619,245 		JBrowse link
G Acp1 acid phosphatase 1 ISO RGD PMID:15281007 RGD:2313183 NCBI chr 6:53,233,937...53,249,576
Ensembl chr 6:47,506,380...47,522,021 		JBrowse link
G Acp7 acid phosphatase 7, tartrate resistant ISO ClinVar Annotator: match by term: Type 2 diabetes mellitus ClinVar PMID:28492532 NCBI chr 1:93,022,801...93,048,484
Ensembl chr 1:83,898,153...83,920,634 		JBrowse link
G Actn4 actinin alpha 4 ISO ClinVar Annotator: match by term: Type 2 diabetes mellitus ClinVar PMID:28492532 NCBI chr 1:93,310,294...93,379,369
Ensembl chr 1:84,182,788...84,251,847 		JBrowse link
G Ada adenosine deaminase ISO protein:increased expression:serum RGD PMID:15168879 RGD:2313539 NCBI chr 3:172,818,174...172,842,283
Ensembl chr 3:152,398,747...152,447,088 		JBrowse link
G Adam17 ADAM metallopeptidase domain 17 ISO protein:increased activity:artery smooth muscle
protein:increased activity:skeletal muscle tissue		 RGD PMID:19581416 PMID:19633828 RGD:2313250, RGD:2312470 NCBI chr 6:46,601,583...46,663,690
Ensembl chr 6:40,872,856...40,920,639 		JBrowse link
G Adamts9 ADAM metallopeptidase with thrombospondin type 1 motif, 9 ISO CTD Direct Evidence: marker/mechanism CTD PMID:18372903 PMID:23967108 NCBI chr 4:126,847,726...127,019,924
Ensembl chr 4:125,291,490...125,462,929 		JBrowse link
G Adcy5 adenylate cyclase 5 ISO
IEP		 CTD Direct Evidence: marker/mechanism CTD
RGD		 PMID:20081858 PMID:23202124 PMID:12607610 RGD:13464136 NCBI chr11:78,976,861...79,123,343
Ensembl chr11:65,471,612...65,618,974 		JBrowse link
G Adipoq adiponectin, C1Q and collagen domain containing ISO
IEP		 protein:decreased expression:plasma, myocardium:
associated with myocardial infarction;protein:decreased expression: :
DNA:SNP: :g.45T>G (human)
CTD Direct Evidence: marker/mechanism		 CTD
RGD		 PMID:12114044 PMID:12354786 PMID:15734870 PMID:19622782 PMID:19708766 More... RGD:2313238, RGD:2313230, RGD:5686359, RGD:5686752, RGD:5686807, RGD:8694412, RGD:14975146 NCBI chr11:91,226,524...91,240,244
Ensembl chr11:77,721,912...77,735,564 		JBrowse link
G Adipor2 adiponectin receptor 2 no_association ISO RGD PMID:18075289 PMID:19631916 PMID:18548168 PMID:18363889 RGD:2312490, RGD:2312476, RGD:2312480, RGD:2312486 NCBI chr 4:154,195,440...154,261,141
Ensembl chr 4:152,524,623...152,559,355 		JBrowse link
G Adm adrenomedullin ISO protein:increased expression:plasma RGD PMID:17557032 RGD:2313313 NCBI chr 1:174,164,178...174,182,372
Ensembl chr 1:164,745,466...164,747,654 		JBrowse link
G Adra2a adrenoceptor alpha 2A susceptibility IEP
ISO		 mRNA, protein:increased expression:pancreatic islet
DNA:SNP:3' utr:rs553668 (human)		 RGD PMID:19965390 PMID:19965390 RGD:2316628, RGD:2316628 NCBI chr 1:263,066,780...263,069,580
Ensembl chr 1:253,060,218...253,064,365 		JBrowse link
G Adra2b adrenoceptor alpha 2B onset ISO DNA:polymorphism (human) RGD PMID:17039423 PMID:17277585 RGD:2313544, RGD:2313543 NCBI chr 3:135,038,481...135,042,527
Ensembl chr 3:114,585,169...114,589,355 		JBrowse link
G Adrb2 adrenoceptor beta 2 no_association ISO DNA:polymorphisms: :p.R16G, p.Q27E RGD
GAD		 PMID:17221209 PMID:15118671 RGD:1601119, RGD:1331525 NCBI chr18:57,912,760...57,914,802
Ensembl chr18:55,502,903...55,644,512 		JBrowse link
G Adrb3 adrenoceptor beta 3 onset
no_association
susceptibility		 ISO DNA:missense mutation: :p.I62M (human)
DNA:missense mutation:cds:p.W64R rs4994 (human)
DNA:polymorphism: :p.W64R (human)		 RGD PMID:16444766 PMID:19659999 PMID:17727676 RGD:2313163, RGD:2313148, RGD:2313149 NCBI chr16:71,544,603...71,547,410
Ensembl chr16:64,841,788...64,844,552 		JBrowse link
G Agap2 ArfGAP with GTPase domain, ankyrin repeat and PH domain 2 ISO RGD PMID:20068140 RGD:13838849 NCBI chr 7:64,782,618...64,799,624
Ensembl chr 7:62,897,282...62,914,295 		JBrowse link
G Ager advanced glycosylation end product-specific receptor treatment
no_association		 ISO
IDA
IEP		 protein:increased expression:jejunum, intestinal villi (rat)
DNA:SNPs:promoter:-374T>A, -429T/C (human)
DNA:polymorphisms, deletion:promoter, :-374T>A, -429T>C (human)
DNA:SNP: :2245A>G (human)
DNA:SNP: :1704G>T, 2184A>G (human)
DNA:SNP: :557G>A (rs2070600, p.G82S) (human)		 RGD PMID:23630304 PMID:19735169 PMID:23403079 PMID:22154374 PMID:15896660 More... RGD:7243184, RGD:7244245, RGD:7244262, RGD:8695962, RGD:8695969, RGD:8695991, RGD:8695991, RGD:8548676 NCBI chr20:4,152,758...4,155,956
Ensembl chr20:4,147,890...4,151,078 		JBrowse link
G Agrp agouti related neuropeptide IEP
ISO		 mRNA:decreased expression:hypothalamus
DNA:polymorphism:promoter:-38C>T (human)		 RGD PMID:18001323 PMID:11554767 RGD:2311538, RGD:2314000 NCBI chr19:50,357,899...50,396,758
Ensembl chr19:33,447,992...33,449,584 		JBrowse link
G Agt angiotensinogen no_association ISO mRNA, protein:increased expression:smooth muscle cell, carotid artery
DNA:polymorphism: :p.T174M, p.M235T (human)		 RGD PMID:17170378 PMID:9258285 RGD:1601138, RGD:8548863 NCBI chr19:69,426,540...69,447,017
Ensembl chr19:52,529,185...52,540,977 		JBrowse link
G Agtr2 angiotensin II receptor, type 2 IEP mRNA, protein:increased expression:aorta RGD PMID:18463192 RGD:2313550 NCBI chr  X:116,914,320...116,918,504
Ensembl chr  X:112,120,228...112,124,057 		JBrowse link
G Ahi1 Abelson helper integration site 1 ISO mRNA:increased expression:vastus lateralis RGD PMID:20045148 RGD:11537398 NCBI chr 1:17,580,859...17,711,775
Ensembl chr 1:15,762,462...15,891,041 		JBrowse link
G Ahsg alpha-2-HS-glycoprotein susceptibility ISO DNA:polymorphism: :-469T>G (rs2077119) (human) RGD PMID:18316360 PMID:18633113 RGD:2313812, RGD:2313811 NCBI chr11:91,625,975...91,632,583
Ensembl chr11:78,117,918...78,145,999 		JBrowse link
G Ak1 adenylate kinase 1 IEP protein:increased expression:gastrocnemius muscle (rat) RGD PMID:20127051 RGD:5134362 NCBI chr 3:36,310,113...36,320,760
Ensembl chr 3:15,912,485...15,923,041 		JBrowse link
G Akr1b1 aldo-keto reductase family 1 member B1 susceptibility ISO DNA:repeat, snp:promoter:g.(AC)n, g.-106C>T (human) RGD PMID:15569136 RGD:8548678 NCBI chr 4:63,899,222...63,913,315
Ensembl chr 4:62,932,031...62,946,157 		JBrowse link
G Akt1 AKT serine/threonine kinase 1 treatment ISO
IDA
IEP		 protein:increased serine phosphorylation:vascular associated smooth muscle cell
CTD Direct Evidence: marker/mechanism		 CTD
RGD		 PMID:31626838 PMID:19289493 PMID:19052261 PMID:24735788 RGD:2311130, RGD:2313556, RGD:39128151 NCBI chr 6:137,534,810...137,555,131
Ensembl chr 6:131,713,720...131,733,921 		JBrowse link
G Akt2 AKT serine/threonine kinase 2 ISO
ISS		 DNA:missense mutation:cds:p.R274H (human)
protein:decreased activity, phosphorylation:vastus lateralis (human)
ClinVar Annotator: match by term: Type 2 diabetes mellitus
CTD Direct Evidence: marker/mechanism
OMIM:125853 | OMIM:601283 | OMIM:601407 | OMIM:603694 | OMIM:608036
ClinVar Annotator: match by term: Diabetes mellitus, noninsulin-dependent, late onset | ClinVar Annotator: match by term: Type 2 diabetes mellitus		 OMIM
ClinVar
CTD
MouseDO
RGD		 PMID:9536098 PMID:15166380 PMID:16722806 PMID:17327441 PMID:17576681 More... RGD:2313408, RGD:2313405, RGD:2307342, RGD:2311130, RGD:734545 NCBI chr 1:92,004,705...92,061,420
Ensembl chr 1:82,883,547...82,933,817 		JBrowse link
G Aldh2 aldehyde dehydrogenase 2 family member ISO RGD PMID:15563966 RGD:2311149 NCBI chr12:40,610,244...40,643,220
Ensembl chr12:34,901,219...34,982,521 		JBrowse link
G Aldob aldolase, fructose-bisphosphate B IDA
ISO
IEP		 DNA:SNP:intron: (human)
mRNA:decreased expression:soleus (rat)		 RGD PMID:19106228 PMID:12646233 PMID:19106228 RGD:2313414, RGD:2313434, RGD:2313414 NCBI chr 5:68,684,541...68,697,582
Ensembl chr 5:63,889,046...63,902,116 		JBrowse link
G Alms1 ALMS1, centrosome and basal body associated protein no_association ISO DNA:SNPs: :rs1320374, rs1881245, rs3820700 (human) RGD PMID:16601972 RGD:8696017 NCBI chr 4:119,683,085...119,783,471
Ensembl chr 4:118,125,607...118,226,005 		JBrowse link
G Alox12 arachidonate 12-lipoxygenase, 12S type ISO protein:decreased activity:platelet (human) RGD PMID:9500559 RGD:2313877 NCBI chr10:55,456,923...55,469,239
Ensembl chr10:54,958,271...54,970,542 		JBrowse link
G Angpt2 angiopoietin 2 ISO protein:increased expression:plasma RGD PMID:15823283 RGD:2313815 NCBI chr16:77,790,760...77,841,241
Ensembl chr16:71,088,364...71,138,804 		JBrowse link
G Angptl3 angiopoietin-like 3 ISO protein:increased expression:liver RGD PMID:15094378 RGD:2314234 NCBI chr 5:118,818,494...118,825,531
Ensembl chr 5:113,703,012...113,709,957 		JBrowse link
G Ankrd23 ankyrin repeat domain 23 IEP RNA:altered expression:heart, brown adipose tissue, skeletal muscle tissue RGD PMID:12456686 RGD:2314859 NCBI chr 9:46,269,107...46,274,578
Ensembl chr 9:38,773,240...38,779,839 		JBrowse link
G Aoc3 amine oxidase, copper containing 3 ISO
IDA		 protein:increased expression:serum RGD PMID:14656718 PMID:12663473 PMID:19336232 RGD:2313822, RGD:2313823, RGD:2313820 NCBI chr10:86,773,018...86,780,961 JBrowse link
G Ap3s2 adaptor related protein complex 3 subunit sigma 2 ISO CTD Direct Evidence: marker/mechanism CTD PMID:21874001 NCBI chr 1:143,228,131...143,268,573
Ensembl chr 1:133,818,825...133,859,322 		JBrowse link
G Apln apelin ISO protein:decreased expression:plasma RGD PMID:18484561 RGD:2313944 NCBI chr  X:132,058,739...132,091,518
Ensembl chr  X:127,203,823...127,213,391 		JBrowse link
G Aplnr apelin receptor ISO protein:decreased expression:renal artery RGD PMID:17692936 RGD:2313945 NCBI chr 3:90,624,055...90,627,700
Ensembl chr 3:70,217,385...70,221,050 		JBrowse link
G Apoa1 apolipoprotein A1 ISO protein:altered localization:plasma lipoprotein particle
protein:increased expression, increased glycation:plasma		 RGD PMID:9649952 PMID:18079481 RGD:2313961, RGD:7241576 NCBI chr 8:55,423,945...55,425,729
Ensembl chr 8:46,527,144...46,529,035 		JBrowse link
G Apoa2 apolipoprotein A2 ISO protein:altered localization:plasma lipoprotein particle
protein:decreased expression:serum		 RGD PMID:9649952 PMID:19817643 RGD:2313961, RGD:2313955 NCBI chr13:86,176,767...86,178,819
Ensembl chr13:83,644,470...83,646,355 		JBrowse link
G Apoa5 apolipoprotein A5 no_association ISO DNA:polymorphism: :c.553G>T (human)
DNA:polymorphism: :-1131T>C (human)		 RGD PMID:17087641 PMID:16039297 PMID:17548321 RGD:2313319, RGD:2313321, RGD:2313318 NCBI chr 8:55,446,329...55,460,509
Ensembl chr 8:46,561,229...46,563,816 		JBrowse link
G Apob apolipoprotein B treatment ISO RGD PMID:18945923 PMID:15161783 RGD:2313981, RGD:11354945 NCBI chr 6:36,563,704...36,603,300
Ensembl chr 6:30,844,368...30,892,497 		JBrowse link
G Apoc1 apolipoprotein C1 ISO protein:decreased expression:plasma RGD PMID:3757210 RGD:2313953 NCBI chr 1:88,475,018...88,479,052
Ensembl chr 1:79,346,136...79,350,375 		JBrowse link
G Apoc2 apolipoprotein C2 ISO protein:increased expression:plasma RGD PMID:3757210 PMID:12733353 RGD:2313953, RGD:2313966 NCBI chr 1:88,457,397...88,462,365
Ensembl chr 1:79,329,428...79,334,476 		JBrowse link
G Apod apolipoprotein D ISO DNA:polymorphism RGD PMID:15369805 PMID:7895459 RGD:2311177, RGD:2311178 NCBI chr11:82,936,216...82,957,264
Ensembl chr11:69,431,260...69,452,305 		JBrowse link
G Apoe apolipoprotein E ISO protein:increased expression:pancreatic islet RGD
GAD		 PMID:18950899 PMID:15118671 RGD:2317556, RGD:1331525 NCBI chr 1:88,481,889...88,485,816
Ensembl chr 1:79,353,916...79,357,932 		JBrowse link
G Apoh apolipoprotein H ISO RGD PMID:16126948 RGD:2313984 NCBI chr10:93,841,992...93,855,897
Ensembl chr10:93,310,977...93,356,329 		JBrowse link
G Apom apolipoprotein M susceptibility ISO DNA:SNP:promoter:g.-778T>C(rs805296)(human) RGD PMID:16572495 RGD:2314248 NCBI chr20:3,695,618...3,698,218
Ensembl chr20:3,688,413...3,693,550 		JBrowse link
G Aqp7 aquaporin 7 ISO protein:increased expression:skeletal muscle: RGD PMID:29783856 RGD:13782361 NCBI chr 5:60,968,495...60,982,618
Ensembl chr 5:56,172,519...56,186,642 		JBrowse link
G Ar androgen receptor ISS OMIM:125853 | OMIM:601283 | OMIM:601407 | OMIM:603694 | OMIM:608036 MouseDO NCBI chr  X:67,135,317...67,304,476
Ensembl chr  X:63,104,771...63,273,925 		JBrowse link
G Arnt aryl hydrocarbon receptor nuclear translocator ISO mRNA:decreased expression:pancreatic islet RGD PMID:16096055 RGD:2313995 NCBI chr 2:185,686,703...185,745,546
Ensembl chr 2:182,997,736...183,056,580 		JBrowse link
G Arrb2 arrestin, beta 2 treatment IEP RGD PMID:24337852 RGD:13506901 NCBI chr10:55,645,539...55,653,485
Ensembl chr10:55,146,818...55,154,850 		JBrowse link
G Arx aristaless related homeobox IEP RGD PMID:16772326 RGD:1599258 NCBI chr  X:62,010,097...62,022,009
Ensembl chr  X:58,016,233...58,028,142 		JBrowse link
G Asip agouti signaling protein ISO
ISS		 mRNA:increased expression:adipose tissue
OMIM:125853 | OMIM:601283 | OMIM:601407 | OMIM:603694 | OMIM:608036
CTD Direct Evidence: marker/mechanism		 MouseDO
CTD
RGD		 PMID:8146154 PMID:14633851 RGD:2313999 NCBI chr 3:163,933,768...164,021,377
Ensembl chr 3:143,555,696...143,561,171 		JBrowse link
G Asl argininosuccinate lyase ISO mRNA:increased expression:leukocyte RGD PMID:16121806 RGD:2314010 NCBI chr12:32,295,779...32,313,257
Ensembl chr12:26,659,565...26,679,662 		JBrowse link
G Atf3 activating transcription factor 3 ISO CTD Direct Evidence: marker/mechanism CTD PMID:16123366 NCBI chr13:105,274,103...105,331,653
Ensembl chr13:102,751,321...102,764,631 		JBrowse link
G Atp2a1 ATPase sarcoplasmic/endoplasmic reticulum Ca2+ transporting 1 IEP RGD PMID:22009485 RGD:6771327 NCBI chr 1:190,457,198...190,475,410
Ensembl chr 1:181,026,608...181,044,838 		JBrowse link
G Atp2a2 ATPase sarcoplasmic/endoplasmic reticulum Ca2+ transporting 2 IEP
ISO
IDA		 mRNA:decreased expression:heart left ventricle
CTD Direct Evidence: marker/mechanism		 CTD
RGD		 PMID:16123366 PMID:21216827 PMID:22009485 PMID:27222135 RGD:6892953, RGD:6771327, RGD:13782085 NCBI chr12:39,733,519...39,782,942
Ensembl chr12:34,072,683...34,122,101 		JBrowse link
G Atp2a3 ATPase sarcoplasmic/endoplasmic reticulum Ca2+ transporting 3 ISO CTD Direct Evidence: marker/mechanism CTD PMID:16123366 NCBI chr10:58,079,710...58,111,279
Ensembl chr10:57,582,128...57,612,748 		JBrowse link
G Atp5f1b ATP synthase F1 subunit beta IEP protein:decreased expression:islet of Langerhans (rat) RGD PMID:21117707 RGD:13792619 NCBI chr 7:1,100,058...1,106,461
Ensembl chr 7:515,460...567,273 		JBrowse link
G Auts2 activator of transcription and developmental regulator AUTS2 ISO CTD Direct Evidence: marker/mechanism CTD PMID:30718926 NCBI chr12:29,739,138...30,830,386
Ensembl chr12:24,104,192...25,194,416 		JBrowse link
G Avp arginine vasopressin IEP protein:increased expression:hypothalamus RGD PMID:17940875 RGD:2301922 NCBI chr 3:138,246,544...138,248,522
Ensembl chr 3:117,793,457...117,795,425 		JBrowse link
G Axl Axl receptor tyrosine kinase ISO RGD PMID:10528229 RGD:2325834 NCBI chr 1:90,392,864...90,424,123
Ensembl chr 1:81,265,088...81,296,265 		JBrowse link
G B2m beta-2 microglobulin ISO protein:increased expression:serum RGD PMID:15127324 RGD:2311236 NCBI chr 3:129,549,236...129,555,354
Ensembl chr 3:109,095,729...109,101,766 		JBrowse link
G Bace2 beta-secretase 2 treatment ISO RGD PMID:28337562 RGD:13782177 NCBI chr11:50,176,852...50,258,948
Ensembl chr11:36,707,458...36,789,546 		JBrowse link
G Bad BCL2-associated agonist of cell death IEP RGD PMID:23032698 RGD:10053698 NCBI chr 1:213,562,719...213,572,034
Ensembl chr 1:204,131,501...204,142,823 		JBrowse link
G Bax BCL2 associated X, apoptosis regulator treatment IEP
ISO		 CTD Direct Evidence: marker/mechanism CTD
RGD		 PMID:31626838 PMID:22543177 RGD:10054139 NCBI chr 1:105,076,472...105,081,906
Ensembl chr 1:95,938,808...95,945,368 		JBrowse link
G Bche butyrylcholinesterase susceptibility ISO DNA:polymorphism: :p.A539T (human) RGD
GAD		 PMID:11793025 PMID:15118671 PMID:16442234 RGD:2306782, RGD:1331525, RGD:2306780 NCBI chr 2:160,607,289...160,699,760
Ensembl chr 2:158,307,584...158,401,148 		JBrowse link
G Bcl2 BCL2, apoptosis regulator IEP
ISO		 CTD Direct Evidence: marker/mechanism CTD
RGD		 PMID:16959961 PMID:31626838 PMID:23032698 RGD:10053698 NCBI chr13:23,204,464...23,366,900
Ensembl chr13:22,684,989...22,853,743
Ensembl chr13:22,684,989...22,853,743 		JBrowse link
G Bcl2l1 Bcl2-like 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:16959961 NCBI chr 3:161,713,777...161,764,844
Ensembl chr 3:141,253,523...141,303,479
Ensembl chr 1:141,253,523...141,303,479 		JBrowse link
G Bcl2l11 Bcl2-like 11 ISO CTD Direct Evidence: marker/mechanism CTD PMID:28869590 NCBI chr 3:135,820,042...135,857,330
Ensembl chr 3:115,366,646...115,404,068 		JBrowse link
G Bdnf brain-derived neurotrophic factor ISO protein:decreased expression:plasma RGD PMID:17151862 RGD:10059350 NCBI chr 3:116,619,633...116,670,212
Ensembl chr 3:96,165,042...96,215,615 		JBrowse link
G Becn1 beclin 1 treatment IEP RGD PMID:21820301 RGD:11561956 NCBI chr10:86,731,649...86,747,002
Ensembl chr10:86,231,388...86,246,742 		JBrowse link
G Bglap bone gamma-carboxyglutamate protein ISO protein:decreased expression:serum: RGD PMID:15747054 RGD:7207410 NCBI chr 2:176,136,341...176,137,318
Ensembl chr 2:173,838,518...173,839,495 		JBrowse link
G Bhmt betaine-homocysteine S-methyltransferase ISO CTD Direct Evidence: marker/mechanism CTD PMID:23665415 NCBI chr 2:26,594,852...26,614,429
Ensembl chr 2:24,859,873...24,879,742 		JBrowse link
G Bmal2 basic helix-loop-helix ARNT like 2 ISO DNA:SNPs: :rs7950226, rs11022775(human) RGD PMID:17728404 RGD:2314371 NCBI chr 4:181,429,097...181,478,384
Ensembl chr 4:179,699,502...179,746,949 		JBrowse link
G Braf B-Raf proto-oncogene, serine/threonine kinase ISO CTD Direct Evidence: marker/mechanism CTD PMID:28869590 NCBI chr 4:69,329,772...69,476,931
Ensembl chr 4:68,384,649...68,510,463 		JBrowse link
G Bscl2 BSCL2 lipid droplet biogenesis associated, seipin no_association IAGP RGD PMID:12584444 RGD:1600600 NCBI chr 1:215,160,764...215,172,540
Ensembl chr 1:205,733,872...205,743,421 		JBrowse link
G Btc betacellulin susceptibility ISO DNA:polymorphism:promoter:-226A/G (human)
DNA:polymorphism:exon:p.C7G (human)		 RGD PMID:16306376 PMID:15793259 RGD:2306967, RGD:2306973 NCBI chr14:16,992,668...17,031,178
Ensembl chr14:16,707,982...16,747,049 		JBrowse link
G C12h12orf43 similar to human chromosome 12 open reading frame 43 ISO ClinVar Annotator: match by term: Type 2 diabetes mellitus ClinVar PMID:25057215 PMID:25741868 NCBI chr12:47,332,740...47,338,461
Ensembl chr12:41,672,114...41,677,714 		JBrowse link
G C17h10orf67 similar to human chromosome 10 open reading frame 67 ISO ClinVar Annotator: match by term: Type 2 diabetes mellitus ClinVar NCBI chr17:86,970,801...87,082,723
Ensembl chr17:82,071,838...82,174,353 		JBrowse link
G C1h19orf47 similar to human chromosome 19 open reading frame 47 ISO ClinVar Annotator: match by term: Type 2 diabetes mellitus ClinVar PMID:28492532 NCBI chr 1:91,971,879...92,010,938
Ensembl chr 1:82,844,286...82,868,320 		JBrowse link
G C2cd4a C2 calcium-dependent domain containing 4A ISO CTD Direct Evidence: marker/mechanism CTD PMID:20818381 NCBI chr 8:77,348,161...77,359,996
Ensembl chr 8:68,466,664...68,470,031 		JBrowse link
G C2cd4b C2 calcium-dependent domain containing 4B ISO CTD Direct Evidence: marker/mechanism CTD PMID:20818381 NCBI chr 8:77,254,327...77,277,620
Ensembl chr 8:68,384,847...68,396,328 		JBrowse link
G C3 complement C3 ISO CTD Direct Evidence: marker/mechanism CTD PMID:20504758 NCBI chr 9:2,174,412...2,201,339
Ensembl chr 9:2,087,437...2,114,429 		JBrowse link
G Cacna1d calcium voltage-gated channel subunit alpha1 D susceptibility ISO DNA:SNPs: :rs9841978,rs312486(human)
mRNA:decreased expression:pancreatic islet:		 RGD PMID:23229155 PMID:23229155 RGD:13506727, RGD:13506727 NCBI chr16:5,233,682...5,527,549
Ensembl chr16:5,228,306...5,668,215 		JBrowse link
G Cadm2 cell adhesion molecule 2 ISO DNA:SNP: :rs13078807 (human) RGD PMID:28401323 RGD:15092076 NCBI chr11:17,994,856...18,971,895
Ensembl chr11:4,555,159...5,525,400 		JBrowse link
G Calca calcitonin-related polypeptide alpha IEP
ISO		 protein:decreased expression:dorsal root ganglion, neuron RGD PMID:17151309 PMID:19816194 RGD:2314035, RGD:2314032 NCBI chr 1:178,312,636...178,317,588
Ensembl chr 1:168,878,214...168,883,105 		JBrowse link
G Calm1 calmodulin 1 IEP mRNA:decreased expression:heart RGD PMID:21216827 RGD:6892953 NCBI chr 6:125,217,191...125,227,855
Ensembl chr 6:119,487,621...119,498,227 		JBrowse link
G Capn10 calpain 10 ISO
IEP
IAGP		 mRNA:increased expression:pancreas
mRNA:decreased expression
DNA:SNP
DNA:polymorphism
associated with Hypertension;DNA:SNPs:intron:rs3792267, rs2975760 (human)
DNA:SNP:intron:rs2975760 (human)
CTD Direct Evidence: marker/mechanism		 CTD
RGD		 PMID:23349674 PMID:19688040 PMID:14646187 PMID:14658759 PMID:16721485 More... RGD:4107074, RGD:1625063, RGD:737693, RGD:1625049, RGD:7247733, RGD:7247734, RGD:7247735 NCBI chr 9:100,943,665...100,957,910
Ensembl chr 9:93,498,478...93,510,494 		JBrowse link
G Capn12 calpain 12 ISO ClinVar Annotator: match by term: Type 2 diabetes mellitus ClinVar PMID:28492532 NCBI chr 1:93,298,571...93,311,220
Ensembl chr 1:84,171,059...84,183,119 		JBrowse link
G Cartpt CART prepropeptide IEP
ISO		 protein:increased expression:pancreatic B cell
mRNA:increased expression:pancreatic islet:		 RGD PMID:16443761 PMID:27338624 PMID:27338624 RGD:2313632, RGD:597805937, RGD:597805937 NCBI chr 2:32,989,215...32,991,794
Ensembl chr 2:31,255,098...31,290,713 		JBrowse link
G Casp12 caspase 12 IEP RGD PMID:23032698 RGD:10053698 NCBI chr 8:10,927,188...10,954,442
Ensembl chr 8:2,642,434...2,674,037 		JBrowse link
G Casp3 caspase 3 ISO protein:increased activity:pancreatic B cell
CTD Direct Evidence: marker/mechanism		 CTD
RGD		 PMID:15531508 PMID:19100955 RGD:2311446 NCBI chr16:52,395,539...52,413,794
Ensembl chr16:45,662,910...45,684,648 		JBrowse link
G Casp7 caspase 7 IEP RGD PMID:23032698 RGD:10053698 NCBI chr 1:265,442,647...265,481,938
Ensembl chr 1:255,437,172...255,476,729 		JBrowse link
G Casp8 caspase 8 ISO CTD Direct Evidence: marker/mechanism CTD
RGD		 PMID:15531508 PMID:17563067 RGD:2311429 NCBI chr 9:67,747,109...67,806,699
Ensembl chr 9:60,264,075...60,312,542 		JBrowse link
G Casp9 caspase 9 ISO DNA:SNP (human) RGD PMID:16038259 RGD:2311246 Ensembl chr 5:154,109,046...154,126,626 JBrowse link
G Casq1 calsequestrin 1 no_association ISO DNA:snp: :rs617698(human)
DNA:snps: :multiple
DNA:snp: :rs2275703(human)		 RGD PMID:18269685 PMID:15561963 PMID:15561962 PMID:17681849 RGD:2314133, RGD:2314135, RGD:2314136, RGD:2314134 NCBI chr13:87,203,021...87,212,710
Ensembl chr13:84,670,649...84,680,339 		JBrowse link
G Cat catalase ISO protein:decreased activity:plasma:
CTD Direct Evidence: marker/mechanism|therapeutic		 CTD
RGD		 PMID:15111504 PMID:15531508 PMID:12357295 RGD:9068922 NCBI chr 3:110,297,340...110,329,526
Ensembl chr 3:89,842,399...89,874,478 		JBrowse link
G Cbs cystathionine beta synthase ISO CTD Direct Evidence: marker/mechanism CTD PMID:23665415 NCBI chr20:9,709,394...9,733,925
Ensembl chr20:9,708,090...9,732,764 		JBrowse link
G Ccdc92 coiled-coil domain containing 92 ISO CTD Direct Evidence: marker/mechanism CTD PMID:28869590 NCBI chr12:37,457,676...37,484,080
Ensembl chr12:31,796,684...31,823,337 		JBrowse link
G Cckar cholecystokinin A receptor IAGP DNA:deletion RGD PMID:16815799 RGD:1625200 NCBI chr14:61,505,270...61,513,618
Ensembl chr14:57,292,397...57,300,747 		JBrowse link
G Ccl2 C-C motif chemokine ligand 2 treatment IEP protein:increased expression:urine RGD PMID:18388116 PMID:25899686 RGD:2301862, RGD:14995493 NCBI chr10:67,503,077...67,504,875
Ensembl chr10:67,005,424...67,007,226 		JBrowse link
G Ccl5 C-C motif chemokine ligand 5 ISO protein:increased expression:serum RGD PMID:17966842 RGD:2307064 NCBI chr10:68,820,330...68,824,906
Ensembl chr10:68,322,829...68,327,377 		JBrowse link
G Ccn2 cellular communication network factor 2 IEP mRNA, protein:increased expression:left ventricle (rat) RGD PMID:19902320 RGD:2314357 NCBI chr 1:22,621,498...22,624,614
Ensembl chr 1:20,802,199...20,805,734 		JBrowse link
G Ccnd2 cyclin D2 ISO CTD Direct Evidence: marker/mechanism CTD PMID:24464100 NCBI chr 4:161,653,048...161,675,422
Ensembl chr 4:159,962,363...159,989,495 		JBrowse link
G Ccr2 C-C motif chemokine receptor 2 ISO protein:increased expression:monocyte RGD PMID:16631114 RGD:2313561 NCBI chr 8:132,611,883...132,619,106
Ensembl chr 8:123,734,430...123,742,100 		JBrowse link
G Ccr5 C-C motif chemokine receptor 5 treatment ISO
IEP		 protein:increased expression:monocyte RGD PMID:17966842 PMID:23063706 RGD:2307064, RGD:8552229 NCBI chr 8:132,629,097...132,660,980
Ensembl chr 8:123,752,325...123,759,260 		JBrowse link
G Cd36 CD36 molecule severity ISO
IEP		 protein:increased expression:plasma
protein:increased expression:aorta
DNA:SNP:promoter
DNA:nonsense mutation: :p.L360X
protein:increased expression:heart
protein:increased expression:platelet
CTD Direct Evidence: marker/mechanism
ClinVar Annotator: match by term: Type 2 diabetes mellitus		 CTD
ClinVar
RGD		 PMID:16911630 PMID:16952981 PMID:25741868 PMID:31626838 PMID:32347024 More... RGD:2307212, RGD:2307211, RGD:2307213, RGD:2307218, RGD:2307219, RGD:6893499, RGD:11040908 NCBI chr 4:18,209,088...18,302,142
Ensembl chr 4:17,354,466...17,513,903 		JBrowse link
G Cd38 CD38 molecule ISO
IEP		 mRNA:decreased expression:pancreatic islet
DNA:missense mutation: :p.R140W (human)		 RGD PMID:12242463 PMID:7669044 PMID:9754820 RGD:2307232, RGD:2307234, RGD:2307233 NCBI chr14:71,384,532...71,424,794
Ensembl chr14:67,172,063...67,211,986 		JBrowse link
G Cd40lg CD40 ligand ISO protein:increased expression:serum
associated with non-alcoholic steatohepatitis;mRNA:increased expression:visceral abdominal adipose tissue		 RGD PMID:16423632 PMID:19280268 RGD:2314214, RGD:5688143 NCBI chr  X:140,164,341...140,176,057
Ensembl chr  X:135,126,969...135,138,306 		JBrowse link
G Cdk4 cyclin-dependent kinase 4 no_association ISO DNA:polymorphism:intron:IVS4-40G>A (human) RGD PMID:18678431 PMID:19695727 RGD:2314611, RGD:2314610 NCBI chr 7:64,771,453...64,774,891
Ensembl chr 7:62,883,105...62,942,403 		JBrowse link
G Cdkal1 CDK5 regulatory subunit associated protein 1-like 1 ISO
ISS		 DNA:snps: :multiple
DNA:snp: :rs7754840(human)
CTD Direct Evidence: marker/mechanism
ClinVar Annotator: match by term: Type 2 diabetes mellitus
OMIM:125853 | OMIM:601283 | OMIM:601407 | OMIM:603694 | OMIM:608036		 CTD
ClinVar
MouseDO
RGD		 PMID:17460697 PMID:17463246 PMID:17463248 PMID:17463249 PMID:23104008 More... RGD:2313941, RGD:2313949, RGD:2313947 NCBI chr17:34,927,221...35,479,827
Ensembl chr17:34,718,687...35,407,524 		JBrowse link
G Cdo1 cysteine dioxygenase type 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:23665415 NCBI chr18:41,619,076...41,633,719
Ensembl chr18:39,432,474...39,447,296 		JBrowse link
G Cel carboxyl ester lipase ISO DNA:deletion:exon
ClinVar Annotator: match by term: Type 2 diabetes mellitus		 ClinVar
RGD		 PMID:25741868 PMID:16369531 RGD:2313964 NCBI chr 3:32,281,518...32,289,019
Ensembl chr 3:11,883,532...11,891,035 		JBrowse link
G Chi3l1 chitinase 3 like 1 ISO protein:increased secretion:plasma (human) RGD PMID:21143859 RGD:4892628 NCBI chr13:48,193,839...48,201,822
Ensembl chr13:45,641,802...45,649,787 		JBrowse link
G Cisd2 CDGSH iron sulfur domain 2 ISO CTD Direct Evidence: marker/mechanism CTD PMID:28869590 NCBI chr 2:226,502,517...226,527,325
Ensembl chr 2:223,828,937...223,868,946 		JBrowse link
G Clps colipase susceptibility ISO DNA:polymorphism:exon:p.R109C (human) RGD PMID:16189801 RGD:2314627 NCBI chr20:6,622,234...6,624,414
Ensembl chr20:6,620,529...6,622,689 		JBrowse link
G Cmip c-Maf-inducing protein ISO CTD Direct Evidence: marker/mechanism CTD PMID:28869590 NCBI chr19:62,213,402...62,419,443
Ensembl chr19:45,304,031...45,508,709 		JBrowse link
G Cnksr2 connector enhancer of kinase suppressor of Ras 2 ISO CTD Direct Evidence: marker/mechanism CTD PMID:30718926 NCBI chr  X:40,722,843...40,971,730
Ensembl chr  X:36,907,850...37,150,555 		JBrowse link
G Cnr1 cannabinoid receptor 1 ISO RGD PMID:18678611 RGD:2314632 NCBI chr 5:53,204,867...53,230,396
Ensembl chr 5:48,408,574...48,435,099 		JBrowse link
G Col3a1 collagen type III alpha 1 chain IEP RGD PMID:20836762 RGD:7257556 NCBI chr 9:54,866,646...54,902,578
Ensembl chr 9:47,374,593...47,410,547 		JBrowse link
G Cp ceruloplasmin ISO protein:increased expression:serum RGD PMID:19834873 RGD:2314681 NCBI chr 2:104,368,336...104,427,119
Ensembl chr 2:102,439,624...102,498,075 		JBrowse link
G Cpb2 carboxypeptidase B2 ISO protein:increased expression, increased activity:plasma RGD PMID:11836301 RGD:2313645 NCBI chr15:56,967,128...57,015,964
Ensembl chr15:50,557,717...50,606,556 		JBrowse link
G Cpe carboxypeptidase E onset
no_association		 ISO DNA:SNP:cds (rs1583645) (human) RGD PMID:11462236 PMID:9662053 PMID:23776430 RGD:1626183, RGD:1626184, RGD:405650683 NCBI chr16:29,796,707...29,908,647
Ensembl chr16:25,030,276...25,142,233 		JBrowse link
G Cpt1a carnitine palmitoyltransferase 1A IEP
ISO		 CTD Direct Evidence: marker/mechanism CTD
RGD		 PMID:16123366 PMID:19553925 RGD:2311344 NCBI chr 1:209,993,881...210,056,329
Ensembl chr 1:200,565,613...200,627,055 		JBrowse link
G Crhr1 corticotropin releasing hormone receptor 1 IEP mRNA:decreased expression:hypothalamus (rat) RGD PMID:20472052 RGD:5507823 NCBI chr10:89,540,192...89,583,466
Ensembl chr10:89,040,203...89,083,481 		JBrowse link
G Crp C-reactive protein ISO RGD PMID:16764962 RGD:9491772 NCBI chr13:87,694,062...87,695,978
Ensembl chr13:85,124,977...85,175,178 		JBrowse link
G Crtc2 CREB regulated transcription coactivator 2 treatment IMP RGD PMID:23595987 PMID:19706791 RGD:9685169, RGD:9685172 NCBI chr 2:178,007,233...178,017,397
Ensembl chr 2:175,709,644...175,719,763 		JBrowse link
G Cst3 cystatin C ISO protein:increased expression:serum (human) RGD PMID:19887833 RGD:2314295 NCBI chr 3:156,790,061...156,794,116
Ensembl chr 3:136,336,920...136,340,822 		JBrowse link
G Ctf1 cardiotrophin 1 ISS OMIM:125853 | OMIM:601283 | OMIM:601407 | OMIM:603694 | OMIM:608036 MouseDO NCBI chr 1:191,758,512...191,771,259
Ensembl chr 1:182,328,090...182,333,335 		JBrowse link
G Ctsb cathepsin B ISO mRNA:decreased expression:pancreatic islet (human) RGD PMID:19367387 RGD:2315527 NCBI chr15:41,565,607...41,586,479
Ensembl chr15:37,389,629...37,410,500 		JBrowse link
G Ctsl cathepsin L susceptibility ISO mRNA:increased expression:gastrocnemius muscle (mouse)
protein:increased expression:right auricular appendage (human)		 RGD PMID:12941783 PMID:19074676 RGD:2315625, RGD:2315622 NCBI chr17:770,104...776,266
Ensembl chr17:764,309...770,548 		JBrowse link
G Cxcl10 C-X-C motif chemokine ligand 10 ISO RGD PMID:19187771 RGD:2311356 NCBI chr14:15,989,066...15,991,263
Ensembl chr14:15,704,758...15,706,975 		JBrowse link
G Cxcl12 C-X-C motif chemokine ligand 12 ISO protein:increased expression:plasma RGD PMID:18451752 RGD:2306553 NCBI chr 4:152,060,781...152,073,628
Ensembl chr 4:150,388,325...150,401,168 		JBrowse link
G Cyb5r4 cytochrome b5 reductase 4 ISO
ISS		 DNA:deletion:intron:IVSV+7TC (human)
OMIM:125853 | OMIM:601283 | OMIM:601407 | OMIM:603694 | OMIM:608036		 MouseDO
RGD		 PMID:15504981 RGD:2315647 NCBI chr 8:96,860,415...96,925,789
Ensembl chr 8:87,981,116...88,045,832 		JBrowse link
G Cyba cytochrome b-245 alpha chain ISO CTD Direct Evidence: marker/mechanism CTD PMID:15531508 NCBI chr19:67,396,143...67,404,214
Ensembl chr19:50,487,597...50,495,721 		JBrowse link
G Cyp11a1 cytochrome P450, family 11, subfamily a, polypeptide 1 IEP mRNA:decreased expression:testis, Leydig cell (rat) RGD PMID:18481435 RGD:4889107 NCBI chr 8:67,318,665...67,330,196
Ensembl chr 8:58,404,669...58,434,338 		JBrowse link
G Cyp11b2 cytochrome P450, family 11, subfamily b, polypeptide 2 ISO DNA:polymorphism:promoter:-344C>T (human) RGD PMID:18771471 RGD:2307288 NCBI chr 7:108,719,349...108,726,024
Ensembl chr 7:106,838,590...106,845,004 		JBrowse link
G Cyp11b3 cytochrome P450, family 11, subfamily b, polypeptide 3 ISO DNA:polymorphism:promoter:-344C>T (human) RGD PMID:18771471 RGD:2307288 NCBI chr 7:108,689,319...108,694,808
Ensembl chr 7:106,808,559...106,814,048 		JBrowse link
G Cyp1a1 cytochrome P450, family 1, subfamily a, polypeptide 1 ISO DNA:polymorphism:3' UTR:5639T>C (human) RGD PMID:11996959 RGD:2307073 NCBI chr 8:66,991,940...66,998,014
Ensembl chr 8:58,096,077...58,102,125 		JBrowse link
G Cyp1a2 cytochrome P450, family 1, subfamily a, polypeptide 2 ISO CTD Direct Evidence: marker/mechanism CTD PMID:22244987 NCBI chr 8:66,971,261...66,978,149
Ensembl chr 8:58,075,367...58,082,312 		JBrowse link
G Cyp2c6 cytochrome P450, family 2, subfamily C, polypeptide 6 treatment IEP RGD PMID:32742601 RGD:124713564 NCBI chr 1:247,879,058...247,916,804
Ensembl chr 1:237,693,094...238,057,596 		JBrowse link
G Cyp2e1 cytochrome P450, family 2, subfamily e, polypeptide 1 ISO
IEP		 mRNA:increased expression:leukocyte
mRNA, protein:decreased expression:liver
mRNA:decreased expression:liver		 RGD PMID:12534643 PMID:10679205 PMID:10049703 RGD:2313686, RGD:2313687, RGD:2313688 NCBI chr 1:205,269,967...205,280,365
Ensembl chr 1:195,840,058...195,864,023 		JBrowse link
G Cyp3a2 cytochrome P450, family 3, subfamily a, polypeptide 2 EXP CTD Direct Evidence: marker/mechanism CTD PMID:22244987 NCBI chr12:14,321,771...14,343,886
Ensembl chr12:9,015,383...9,285,008 		JBrowse link
G Cyp3a23-3a1 cytochrome P450, family 3, subfamily a, polypeptide 23-polypeptide 1 EXP CTD Direct Evidence: marker/mechanism CTD PMID:22244987 NCBI chr12:14,369,950...14,398,803
Ensembl chr12:9,254,475...9,285,030
Ensembl chr12:9,254,475...9,285,030 		JBrowse link
G Dag1 dystroglycan 1 IEP protein:decreased expression:skeletal muscle RGD PMID:16323284 RGD:1581689 NCBI chr 8:117,769,517...117,834,347
Ensembl chr 8:108,890,929...108,952,325 		JBrowse link
G Dcn decorin ISO protein:increased expression:plasma RGD PMID:18414424 RGD:2311410 NCBI chr 7:34,167,973...34,208,004
Ensembl chr 7:32,281,252...32,321,270 		JBrowse link
G Dcx doublecortin IEP protein:decreased expression:dentate gyrus RGD PMID:18982449 RGD:12904763 NCBI chr  X:112,227,455...112,370,291
Ensembl chr  X:107,430,767...107,507,476 		JBrowse link
G Defb1 defensin beta 1 IEP RGD PMID:14521940 RGD:4892271 NCBI chr16:77,001,326...77,016,068
Ensembl chr16:70,298,863...70,313,604 		JBrowse link
G Dgkd diacylglycerol kinase, delta ISO CTD Direct Evidence: marker/mechanism CTD PMID:30718926 NCBI chr 9:95,964,507...96,055,160
Ensembl chr 9:88,516,715...88,607,345 		JBrowse link
G Dio2 iodothyronine deiodinase 2 no_association ISO DNA:SNP: :rs225014, p.T92A (human) RGD PMID:17077128 RGD:1626439 NCBI chr 6:115,396,308...115,410,594
Ensembl chr 6:109,665,523...109,679,809 		JBrowse link
G Dll3 delta like canonical Notch ligand 3 ISO ClinVar Annotator: match by term: Type 2 diabetes mellitus ClinVar PMID:28492532 NCBI chr 1:92,689,577...92,698,125
Ensembl chr 1:83,562,014...83,569,750 		JBrowse link
G Dnm1l dynamin 1-like treatment IEP RGD PMID:21820301 RGD:11561956 NCBI chr11:98,084,049...98,135,663
Ensembl chr11:84,581,216...84,631,482 		JBrowse link
G Dnmt1 DNA methyltransferase 1 IEP mRNA:increased expression:liver: RGD PMID:21818837 RGD:7207079 NCBI chr 8:27,716,797...27,763,405
Ensembl chr 8:19,440,611...19,486,659 		JBrowse link
G Dpp4 dipeptidylpeptidase 4 ISO RGD PMID:19705345 RGD:2313700 NCBI chr 3:67,370,794...67,452,422
Ensembl chr 3:46,962,243...47,043,901 		JBrowse link
G Drd2 dopamine receptor D2 ISO DNA:polymorphism:exon:32806C>T (human) RGD PMID:18834717 RGD:2311601 NCBI chr 8:58,605,403...58,669,339
Ensembl chr 8:49,708,927...49,772,875 		JBrowse link
G Dyrk1b dual specificity tyrosine phosphorylation regulated kinase 1B ISO ClinVar Annotator: match by term: Type 2 diabetes mellitus ClinVar PMID:28492532 NCBI chr 1:92,606,743...92,624,089
Ensembl chr 1:83,479,147...83,487,169 		JBrowse link
G Ece1 endothelin converting enzyme 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:16387788 NCBI chr 5:155,361,031...155,462,723
Ensembl chr 5:150,077,644...150,179,371 		JBrowse link
G Ech1 enoyl-CoA hydratase 1 ISO ClinVar Annotator: match by term: Type 2 diabetes mellitus ClinVar PMID:28492532 NCBI chr 1:93,241,076...93,248,314
Ensembl chr 1:84,112,751...84,120,795 		JBrowse link
G Edn1 endothelin 1 ISO
IEP		 mRNA:increased expression:blood vessel endothelial cell
protein:increased expression:mesenteric artery
CTD Direct Evidence: marker/mechanism		 CTD
RGD		 PMID:16387788 PMID:19581418 PMID:19286964 RGD:2313278, RGD:2313280 NCBI chr17:22,660,799...22,666,687
Ensembl chr17:22,454,420...22,460,885 		JBrowse link
G Ednra endothelin receptor type A IEP
ISO		 protein:increased expression:mesenteric artery
CTD Direct Evidence: marker/mechanism		 CTD
RGD		 PMID:16387788 PMID:19286964 RGD:2313280 NCBI chr19:47,137,360...47,207,961
Ensembl chr19:30,233,571...30,297,049 		JBrowse link
G Ednrb endothelin receptor type B IDA
ISO		 CTD Direct Evidence: marker/mechanism CTD
RGD		 PMID:16387788 PMID:19286964 RGD:2313280 NCBI chr15:87,055,490...87,086,765
Ensembl chr15:80,643,043...80,672,115 		JBrowse link
G Egfr epidermal growth factor receptor ISO CTD Direct Evidence: marker/mechanism CTD PMID:22238402 NCBI chr14:95,378,626...95,551,358
Ensembl chr14:91,177,067...91,344,382 		JBrowse link
G Eid2 EP300 interacting inhibitor of differentiation 2 ISO ClinVar Annotator: match by term: Type 2 diabetes mellitus ClinVar PMID:28492532 NCBI chr 1:92,665,837...92,667,162 JBrowse link
G Eid2b EP300 interacting inhibitor of differentiation 2B ISO ClinVar Annotator: match by term: Type 2 diabetes mellitus ClinVar PMID:28492532 NCBI chr 1:92,673,119...92,674,899
Ensembl chr 1:83,545,563...83,546,734 		JBrowse link
G Eif3f eukaryotic translation initiation factor 3, subunit F IEP RGD PMID:12875716 RGD:10755506 NCBI chr 1:172,369,062...172,378,043
Ensembl chr 1:162,934,212...162,943,204 		JBrowse link
G Enpp1 ectonucleotide pyrophosphatase/phosphodiesterase 1 ISO NIDDM,OMIM:125853;DNA:polymorphism
CTD Direct Evidence: marker/mechanism
ClinVar Annotator: match by term: DIABETES MELLITUS, TYPE 2, PROTECTION AGAINST | ClinVar Annotator: match by term: Diabetes mellitus type 2, susceptibility to | ClinVar Annotator: match by term: Diabetes mellitus, noninsulin-dependent, late onset | ClinVar Annotator: match by term: Type 2 diabetes mellitus | ClinVar Annotator: match by term: Type II diabetes mellitus		 CTD
ClinVar
OMIM
RGD		 PMID:8960499 PMID:9662402 PMID:10453738 PMID:10480624 PMID:11739459 More... RGD:1601042 NCBI chr 1:22,518,051...22,583,044
Ensembl chr 1:20,698,764...20,763,715 		JBrowse link
G Ep300 E1A binding protein p300 ISO protein:increased serine phosphorylation:renal glomerulus (mouse) RGD PMID:23737551 RGD:7257568 NCBI chr 7:114,987,857...115,058,652
Ensembl chr 7:113,106,247...113,136,088
Ensembl chr 7:113,106,247...113,136,088 		JBrowse link
G Epas1 endothelial PAS domain protein 1 IEP RGD PMID:17914354 RGD:10395377 NCBI chr 6:13,543,252...13,626,147
Ensembl chr 6:7,790,647...7,871,228 		JBrowse link
G Epc2 enhancer of polycomb homolog 2 ISO CTD Direct Evidence: marker/mechanism CTD PMID:30718926 NCBI chr 3:54,276,187...54,376,373
Ensembl chr 3:33,867,219...33,967,150 		JBrowse link
G Epo erythropoietin ISO mRNA:increased expression:retina
protein:decreased expression:plasma		 RGD PMID:16936148 PMID:16911620 RGD:2313840, RGD:2313842 NCBI chr12:24,841,285...24,844,725
Ensembl chr12:19,204,508...19,207,946 		JBrowse link
G Esr1 estrogen receptor 1 ISO DNA:polymorphism
DNA:SNPs:introns: rs3020314, rs985694, rs1884051 (human)		 RGD PMID:17097034 PMID:18854778 RGD:2314012, RGD:2314003 NCBI chr 1:43,511,685...43,904,454
Ensembl chr 1:41,210,475...41,495,002 		JBrowse link
G Esrra estrogen related receptor, alpha no_association ISO RGD PMID:16755280 RGD:1625637 NCBI chr 1:213,533,309...213,543,432
Ensembl chr 1:204,104,101...204,114,268 		JBrowse link
G Ets1 ETS proto-oncogene 1, transcription factor ISO protein:increased expression:nucleus
CTD Direct Evidence: marker/mechanism		 CTD
RGD		 PMID:30718926 PMID:19225563 PMID:19225563 RGD:2313847, RGD:2313847 NCBI chr 8:39,303,936...39,426,022
Ensembl chr 8:31,045,945...31,168,010 		JBrowse link
G F12 coagulation factor XII ISO protein:increased activity:plasma (human) RGD PMID:7974333 RGD:2312416 NCBI chr17:9,212,819...9,220,664
Ensembl chr17:9,207,683...9,215,530 		JBrowse link
G F2 coagulation factor II, thrombin ISO protein:increased expression:plasma
associated with Myocardial Infarction		 RGD PMID:17971179 PMID:18487475 RGD:2313852, RGD:2313851 NCBI chr 3:98,051,958...98,065,246
Ensembl chr 3:77,596,198...77,609,486 		JBrowse link
G F3 coagulation factor III, tissue factor ISO protein:increased activity:plasma RGD PMID:17785358 RGD:2312381 NCBI chr 2:212,511,675...212,523,375
Ensembl chr 2:209,826,959...209,838,668 		JBrowse link
G F7 coagulation factor VII susceptibility
no_association		 ISO
IDA		 associated with Kidney Failure; protein:increased expression:plasma (human)
associated with Brain Infarction; protein:increased activity:plasma (human)		 RGD PMID:10332679 PMID:15860378 PMID:18000605 PMID:17785358 PMID:11689270 More... RGD:2312388, RGD:2312383, RGD:2312380, RGD:2312381, RGD:2312382, RGD:2312394, RGD:2312386 NCBI chr16:83,191,896...83,202,775
Ensembl chr16:76,489,717...76,500,610 		JBrowse link
G F8 coagulation factor VIII ISO protein:increased activity:plasma (human) RGD PMID:7974333 RGD:2312416 NCBI chr18:155,237...187,186
Ensembl chr18:140,955...171,857 		JBrowse link
G F9 coagulation factor IX ISO protein:increased activity:plasma (human) RGD PMID:7974333 RGD:2312416 NCBI chr  X:143,388,642...143,433,143
Ensembl chr  X:138,352,298...138,396,835 		JBrowse link
G Fabp2 fatty acid binding protein 2 no_association ISO ClinVar Annotator: match by term: FABP2 POLYMORPHISM ClinVar
RGD		 PMID:7883976 PMID:9253345 PMID:10946885 PMID:10999802 PMID:12161503 More... RGD:1626401 NCBI chr 2:213,724,629...213,728,686
Ensembl chr 2:211,040,032...211,044,089 		JBrowse link
G Fabp3 fatty acid binding protein 3 susceptibility ISO DNA:deletion:3' utr:c.634+483delT (human) RGD PMID:12872269 RGD:1578461 NCBI chr 5:147,936,027...147,942,870
Ensembl chr 5:142,651,956...142,658,718 		JBrowse link
G Fam234a family with sequence similarity 234, member A ISO CTD Direct Evidence: marker/mechanism CTD PMID:28869590 NCBI chr10:15,736,741...15,768,043
Ensembl chr10:15,232,278...15,263,488 		JBrowse link
G Fas Fas cell surface death receptor ISO CTD Direct Evidence: marker/mechanism CTD PMID:16123366 NCBI chr 1:241,212,155...241,245,774
Ensembl chr 1:231,798,960...231,832,591 		JBrowse link
G Faslg Fas ligand ISO DNA:repeats:3' utr (human) RGD PMID:16691186 RGD:2315750 NCBI chr13:76,680,885...76,706,042
Ensembl chr13:74,154,954...74,162,215 		JBrowse link
G Fbl fibrillarin ISO ClinVar Annotator: match by term: Type 2 diabetes mellitus ClinVar PMID:28492532 NCBI chr 1:92,597,407...92,606,507
Ensembl chr 1:83,469,832...83,478,932 		JBrowse link
G Fbn1 fibrillin 1 IEP RGD PMID:20836762 RGD:7257556 NCBI chr 3:133,007,693...133,204,277
Ensembl chr 3:112,554,925...112,750,889 		JBrowse link
G Fbxo17 F-box protein 17 ISO ClinVar Annotator: match by term: Type 2 diabetes mellitus ClinVar PMID:28492532 NCBI chr 1:93,129,776...93,151,983
Ensembl chr 1:84,002,267...84,024,453 		JBrowse link
G Fbxo27 F-box protein 27 ISO ClinVar Annotator: match by term: Type 2 diabetes mellitus ClinVar PMID:28492532 NCBI chr 1:93,092,900...93,115,312
Ensembl chr 1:83,965,986...83,987,778 		JBrowse link
G Fcgbp Fc gamma binding protein ISO ClinVar Annotator: match by term: Type 2 diabetes mellitus ClinVar PMID:28492532 NCBI chr 1:92,502,461...92,540,658
Ensembl chr 1:83,372,127...83,413,083 		JBrowse link
G Fem1b fem-1 homolog B ISS OMIM:125853 | OMIM:601283 | OMIM:601407 | OMIM:603694 | OMIM:608036 MouseDO NCBI chr 8:72,160,722...72,173,996
Ensembl chr 8:63,265,301...63,278,577 		JBrowse link
G Ffar1 free fatty acid receptor 1 ameliorates ISO RGD PMID:19401434 PMID:19758793 RGD:150517551, RGD:2315761 NCBI chr 1:95,238,785...95,239,689
Ensembl chr 1:86,111,368...86,112,272 		JBrowse link
G Fga fibrinogen alpha chain ISO protein:increased activity:plasma (human) RGD PMID:7974333 RGD:2312416 NCBI chr 2:170,672,169...170,679,572
Ensembl chr 2:168,374,120...168,381,528 		JBrowse link
G Fgb fibrinogen beta chain ISO protein:increased expression:plasma RGD PMID:7974333 RGD:2312416 NCBI chr 2:170,693,966...170,700,875
Ensembl chr 2:168,394,916...168,405,979 		JBrowse link
G Fgf2 fibroblast growth factor 2 ISO protein:increased expression:serum RGD PMID:18279437 RGD:2315844 NCBI chr 2:122,164,454...122,218,796
Ensembl chr 2:120,236,328...120,291,221 		JBrowse link
G Fgf21 fibroblast growth factor 21 treatment ISO CTD Direct Evidence: therapeutic CTD
RGD		 PMID:26797127 PMID:21293445 RGD:10401914 NCBI chr 1:105,219,825...105,221,376
Ensembl chr 1:96,083,441...96,090,454 		JBrowse link
G Fgfr1 Fibroblast growth factor receptor 1 ISO RGD PMID:22174314 RGD:10401888 NCBI chr16:73,194,631...73,249,855
Ensembl chr16:66,494,042...66,547,350 		JBrowse link
G Fgg fibrinogen gamma chain ISO protein:increased activity:plasma (human) RGD PMID:7974333 RGD:2312416 NCBI chr 2:170,652,929...170,660,372
Ensembl chr 2:168,355,013...168,362,322 		JBrowse link
G Flt1 Fms related receptor tyrosine kinase 1 ISO mRNA, protein:decreased expression:skeletal muscle RGD PMID:17823371 RGD:2313719 NCBI chr12:12,333,050...12,504,750
Ensembl chr12:7,297,292...7,468,626 		JBrowse link
G Foxa2 forkhead box A2 no_association ISO DNA:missense mutation:p.A86T (human)
DNA:SNP, repeat: :rs1055080 (human)
DNA:transversion, transitions:promoter, exon:multiple		 RGD PMID:11043867 PMID:18797817 PMID:10868949 RGD:2313245, RGD:2313242, RGD:2313246 NCBI chr 3:155,923,305...155,927,508
Ensembl chr 3:135,470,131...135,474,326 		JBrowse link
G Foxc2 forkhead box C2 no_association ISO DNA:polymorphism:5'ut:-512C>T,-350G>T, 3'ut:1548C>T
DNA:insertion:1006insA		 RGD PMID:12540636 PMID:15523639 RGD:1601220, RGD:1601217 NCBI chr19:66,094,718...66,097,420
Ensembl chr19:49,185,662...49,188,737 		JBrowse link
G Foxm1 forkhead box M1 ISS OMIM:125853 | OMIM:601283 | OMIM:601407 | OMIM:603694 | OMIM:608036 MouseDO NCBI chr 4:163,325,628...163,338,100
Ensembl chr 4:161,638,816...161,650,684 		JBrowse link
G Foxo1 forkhead box O1 treatment ISO protein:altered localization:nucleus, islet cell: RGD PMID:22417654 PMID:20736318 RGD:10044264, RGD:10044265 NCBI chr 2:138,462,974...138,541,420
Ensembl chr 2:136,312,168...136,387,790 		JBrowse link
G Frzb frizzled-related protein ISO protein, decreased expression:skeletal muscle, serum (human) RGD PMID:28240822 RGD:32716394 NCBI chr 3:85,739,162...85,772,168
Ensembl chr 3:65,332,277...65,365,208 		JBrowse link
G Fto FTO, alpha-ketoglutarate dependent dioxygenase susceptibility
no_association		 ISO
IEP		 CTD Direct Evidence: marker/mechanism
DNA:SNP: :rs17817449 (human)
DNA:SNP: :rs9939609 (human)
DNA:SNP: :rs1421085 (human)
DNA:SNP:intron:rs9939609 (human)
DNA:SNPs: :multiple
mRNA:increased expression:blood		 CTD
RGD		 PMID:23104008 PMID:29154870 PMID:21294771 PMID:32061761 PMID:28890888 More... RGD:329813082, RGD:329901762, RGD:329901771, RGD:329901773, RGD:329901856, RGD:329951010 NCBI chr19:31,456,749...31,865,011
Ensembl chr19:15,349,696...15,692,083 		JBrowse link
G Fuca1 alpha-L-fucosidase 1 ISO protein:increased activity:serum RGD PMID:16176171 RGD:2315931 NCBI chr 5:153,436,262...153,453,512
Ensembl chr 5:148,152,700...148,169,972 		JBrowse link
G Fxn frataxin no_association ISO DNA:repeats:intron:GAA (human) RGD PMID:10102715 PMID:9588463 RGD:2307051, RGD:2307050 NCBI chr 1:231,300,457...231,323,989
Ensembl chr 1:221,872,420...221,897,540 		JBrowse link
G G6pc1 glucose-6-phosphatase catalytic subunit 1 ISO
IDA		 protein:increased activity:liver RGD PMID:8865366 PMID:16396963 PMID:10866049 RGD:728661, RGD:2315959, RGD:2315966 NCBI chr10:86,807,659...86,819,023
Ensembl chr10:86,257,668...86,333,804 		JBrowse link
G G6pd glucose-6-phosphate dehydrogenase ISO protein:decreased expression:reticulocyte, erythrocyte RGD PMID:12853069 RGD:2307349 NCBI chr  X:157,352,364...157,372,144
Ensembl chr  X:152,201,098...152,220,801 		JBrowse link
G Gadd45gip1 GADD45G interacting protein 1 ISS OMIM:125853 | OMIM:601283 | OMIM:601407 | OMIM:603694 | OMIM:608036 MouseDO NCBI chr19:40,225,503...40,228,052
Ensembl chr19:23,320,159...23,323,236 		JBrowse link
G Gal galanin and GMAP prepropeptide ISO protein:increased expression:blood RGD PMID:15735230 RGD:2313738 NCBI chr 1:210,079,709...210,084,572
Ensembl chr 1:200,650,439...200,654,959 		JBrowse link
G Gapdh glyceraldehyde-3-phosphate dehydrogenase ISO protein:decreased acetylation RGD PMID:28258188 RGD:13792662 NCBI chr 4:159,648,592...159,653,436
Ensembl chr 4:157,962,343...157,966,235 		JBrowse link
G Gcg glucagon ISO CTD Direct Evidence: marker/mechanism CTD PMID:23466488 NCBI chr 3:67,522,489...67,531,533
Ensembl chr 3:47,113,914...47,122,929 		JBrowse link
G Gcgr glucagon receptor ISO DNA:mutation:exon:G40S
ClinVar Annotator: match by term: Type 2 diabetes mellitus		 ClinVar
RGD		 PMID:7773293 PMID:8563746 PMID:25741868 PMID:28492532 PMID:7773293 RGD:1625208 NCBI chr10:106,306,803...106,314,970
Ensembl chr10:105,808,473...105,816,640 		JBrowse link
G Gch1 GTP cyclohydrolase 1 ISO DNA:SNPs,haplotypes: :multiple RGD PMID:25369080 RGD:329961331 NCBI chr15:22,884,006...22,917,412
Ensembl chr15:20,402,527...20,437,698 		JBrowse link
G Gck glucokinase no_association
treatment		 ISO
IDA
ISS		 DNA:polymorphisms:multiple:no association between multiple SSLP and SNP alleles and T2DM in a Japanese population (human)
DNA:microsatellite marker genotypes:3', 5':no association between genotypes of upstream or downstream microsatellite markers and T2DM in Welsh Caucasians (human)
MODY2, OMIM:125851;DNA:point mutation:E279X
protein:altered localization:hepatocyte:impaired translocation from nucleus to cytoplasm in Zucker diabetic fatty rats
DNA:polymorphisms::significant association between alleles of two SSLPs and T2DM in a Japanese population (human)
CTD Direct Evidence: marker/mechanism
ClinVar Annotator: match by term: Type 2 diabetes mellitus
OMIM:125853 | OMIM:601283 | OMIM:601407 | OMIM:603694 | OMIM:608036
ClinVar Annotator: match by term: Diabetes mellitus, noninsulin-dependent, late onset | ClinVar Annotator: match by term: Type 2 diabetes mellitus		 OMIM
CTD
ClinVar
MouseDO
RGD		 PMID:1360036 PMID:1397713 PMID:1502186 PMID:2555564 PMID:7553875 More... RGD:2301887, RGD:2301883, RGD:1601292, RGD:1582633, RGD:2301889, RGD:7488969 NCBI chr14:84,999,019...85,041,098
Ensembl chr14:80,785,060...80,826,995 		JBrowse link
G Gckr glucokinase regulator ISO DNA:polymorphism: :rs780094 (human)
DNA:SNP::rs1260326(human)
CTD Direct Evidence: marker/mechanism		 CTD
RGD		 PMID:20081858 PMID:19241058 PMID:18556336 PMID:11473043 PMID:21411509 RGD:2315983, RGD:2315985, RGD:2315986, RGD:7242280 NCBI chr 6:30,765,071...30,795,627
Ensembl chr 6:25,045,100...25,075,654 		JBrowse link
G Gclc glutamate-cysteine ligase, catalytic subunit ISO CTD Direct Evidence: therapeutic CTD PMID:32715377 NCBI chr 8:87,510,251...87,548,896
Ensembl chr 8:78,630,127...78,668,544 		JBrowse link
G Gclm glutamate cysteine ligase, modifier subunit ISO CTD Direct Evidence: therapeutic CTD PMID:32715377 NCBI chr 2:213,032,135...213,052,192
Ensembl chr 2:210,347,482...210,367,535 		JBrowse link
G Gfpt1 glutamine fructose-6-phosphate transaminase 1 ISO RGD PMID:17574229 RGD:2313352 NCBI chr 4:121,054,023...121,103,799
Ensembl chr 4:119,496,714...119,546,471 		JBrowse link
G Gfpt2 glutamine-fructose-6-phosphate transaminase 2 susceptibility ISO DNA:missense mutation, SNPs:exon, 3' utr:multiple RGD PMID:14764791 RGD:2307362 NCBI chr10:34,616,146...34,662,420
Ensembl chr10:34,115,052...34,161,329 		JBrowse link
G Ggt1 gamma-glutamyltransferase 1 ISO RGD PMID:19936701 RGD:2315593 NCBI chr20:13,074,141...13,103,551
Ensembl chr20:13,074,700...13,108,442 		JBrowse link
G Gh1 growth hormone 1 treatment IEP RGD PMID:26379831 RGD:11352744 NCBI chr10:91,727,883...91,729,860
Ensembl chr10:91,228,103...91,230,078 		JBrowse link
G Ghr growth hormone receptor ISO DNA:deletion:exon (human) RGD PMID:17537658 RGD:2307363 NCBI chr 2:54,269,066...54,532,595
Ensembl chr 2:52,542,594...52,804,735 		JBrowse link
G Ghrl ghrelin and obestatin prepropeptide susceptibility ISO DNA:polymorphism: :p.L72M (human) RGD PMID:18848536 RGD:2313749 NCBI chr 4:148,421,315...148,431,128
Ensembl chr 4:146,865,712...146,869,621 		JBrowse link
G Gip gastric inhibitory polypeptide ISO
IDA		 disease in rat treated with human protein RGD PMID:18937625 PMID:19126188 PMID:19473824 PMID:19056762 RGD:2312589, RGD:2312591, RGD:2312587, RGD:2312529 NCBI chr10:81,465,070...81,473,216
Ensembl chr10:80,968,352...80,976,503 		JBrowse link
G Gipr gastric inhibitory polypeptide receptor ISO
IAGP		 protein:decreased expression:pancreatic islet (human) RGD PMID:19386626 PMID:11334402 RGD:2312454, RGD:68929 NCBI chr 1:87,932,316...87,956,084
Ensembl chr 1:78,805,593...78,814,462 		JBrowse link
G Gja1 gap junction protein, alpha 1 IEP protein:increased phosphorylation:kidney RGD PMID:21573906 RGD:7207393 NCBI chr20:36,302,490...36,315,010
Ensembl chr20:35,755,991...35,768,582 		JBrowse link
G Glis3 GLIS family zinc finger 3 ISO CTD Direct Evidence: marker/mechanism CTD PMID:22158537 NCBI chr 1:235,389,567...235,809,416
Ensembl chr 1:225,976,326...226,395,899 		JBrowse link
G Glo1 glyoxalase 1 ISO DNA:point mutation: :c.332A>C (human) RGD PMID:18413187 RGD:7242567 NCBI chr20:8,665,061...8,683,095
Ensembl chr20:8,662,801...8,681,649 		JBrowse link
G Glp1r glucagon-like peptide 1 receptor ISO CTD Direct Evidence: marker/mechanism CTD PMID:30718926 NCBI chr20:8,973,393...9,011,622
Ensembl chr20:8,972,004...9,010,241 		JBrowse link
G Gmfg glia maturation factor, gamma ISO ClinVar Annotator: match by term: Type 2 diabetes mellitus ClinVar PMID:28492532 NCBI chr 1:92,856,154...92,866,722
Ensembl chr 1:83,728,776...83,739,183 		JBrowse link
G Gnb3 G protein subunit beta 3 ISO DNA:polymorphism: :825C>T (human)
CTD Direct Evidence: marker/mechanism		 CTD
RGD		 PMID:12511541 PMID:18656447 RGD:2313204 NCBI chr 4:159,325,741...159,331,443
Ensembl chr 4:157,639,469...157,645,173 		JBrowse link
G Gp2 glycoprotein 2 ISO CTD Direct Evidence: marker/mechanism CTD PMID:30718926 NCBI chr 1:183,228,395...183,243,954
Ensembl chr 1:173,797,057...173,812,619 		JBrowse link
G Gp6 glycoprotein VI ISO protein:increased expression:plasma (human)
associated with intermediate coronary syndrome;DNA:missense mutation:CDS: (rs1671152) (human)		 RGD PMID:33859620 PMID:33076381 RGD:401794568, RGD:401794569 NCBI chr 1:78,471,900...78,535,374
Ensembl chr 1:69,465,789...69,491,326 		JBrowse link
G Gpd2 glycerol-3-phosphate dehydrogenase 2 susceptibility ISO CTD Direct Evidence: marker/mechanism
ClinVar Annotator: match by term: GPD2-related condition | ClinVar Annotator: match by term: Type 2 diabetes mellitus		 CTD
OMIM
ClinVar		 PMID:9070847 PMID:16123366 PMID:25741868 PMID:28492532 NCBI chr 3:62,209,432...62,346,590
Ensembl chr 3:41,801,930...41,936,901 		JBrowse link
G Gpt glutamic--pyruvic transaminase IEP protein:increased expression, activity:liver: RGD PMID:25865565 RGD:11342811 NCBI chr 7:110,295,599...110,300,134
Ensembl chr 7:108,416,642...108,419,494 		JBrowse link
G Gpt2 glutamic--pyruvic transaminase 2 IEP protein:increased expression, activity:liver: RGD PMID:25865565 RGD:11342811 NCBI chr19:37,700,023...37,734,551
Ensembl chr19:21,517,621...21,560,610 		JBrowse link
G Gpx1 glutathione peroxidase 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:16123366 PMID:23795780 NCBI chr 8:117,905,462...117,906,588
Ensembl chr 8:109,026,905...109,028,024 		JBrowse link
G Gpx3 glutathione peroxidase 3 treatment ISO protein:decreased expression:plasma (human) RGD PMID:18936159 PMID:24102912 RGD:2312632, RGD:401827847 NCBI chr10:39,529,335...39,537,406
Ensembl chr10:39,028,570...39,037,035 		JBrowse link
G Grb14 growth factor receptor bound protein 14 susceptibility ISO CTD Direct Evidence: marker/mechanism
associated with Environmental Illness; DNA:SNP:: (rs13389219) (Human)		 CTD
RGD		 PMID:21874001 PMID:27281273 RGD:401850598 NCBI chr 3:69,976,331...70,091,921
Ensembl chr 3:49,568,210...49,683,889 		JBrowse link
G Gsk3b glycogen synthase kinase 3 beta treatment ISO
IEP		 RGD PMID:20821187 PMID:27164497 RGD:10045562, RGD:13792739 NCBI chr11:76,004,502...76,154,665
Ensembl chr11:62,504,316...62,648,646 		JBrowse link
G Gstm1 glutathione S-transferase mu 1 no_association
susceptibility		 ISO DNA:deletion: :
CTD Direct Evidence: marker/mechanism		 CTD
RGD		 PMID:22652274 PMID:16413497 PMID:17979505 PMID:20739761 RGD:2306628, RGD:2306627, RGD:5490963 NCBI chr 2:198,338,005...198,346,007
Ensembl chr 2:195,649,845...195,655,411 		JBrowse link
G Gstp1 glutathione S-transferase pi 1 susceptibility ISO DNA:polymorphism:exon:p.I105V (rs1695) (human) RGD PMID:20739761 RGD:5490963 NCBI chr 1:210,767,237...210,770,242
Ensembl chr 1:201,321,672...201,340,226 		JBrowse link
G Gstt1 glutathione S-transferase theta 1 susceptibility ISO RGD PMID:17979505 RGD:2306627 NCBI chr20:12,856,068...12,873,020
Ensembl chr20:12,856,669...12,873,585 		JBrowse link
G H19 H19 imprinted maternally expressed transcript sexual_dimorphism ISO RNA:decrased expression:blood serum (human) RGD PMID:33116722 RGD:243048436 NCBI chr 1:207,160,175...207,162,851
Ensembl chr 1:197,730,698...197,733,134 		JBrowse link
G Hba-a2 hemoglobin alpha, adult chain 2 ISO CTD Direct Evidence: marker/mechanism CTD PMID:16632892 NCBI chr10:15,828,291...15,829,138
Ensembl chr10:15,307,815...15,338,392
Ensembl chr10:15,307,815...15,338,392 		JBrowse link
G Hdac1 histone deacetylase 1 ISO protein:increased activity:kidney: RGD PMID:19553350 RGD:9590229 NCBI chr 5:147,138,328...147,165,387
Ensembl chr 5:141,853,989...141,881,111 		JBrowse link
G Hdac2 histone deacetylase 2 ISO protein:increased activity:kidney: RGD PMID:19553350 RGD:9590229 NCBI chr20:42,101,815...42,126,486
Ensembl chr20:40,548,250...40,571,609 		JBrowse link
G Hectd4 HECT domain E3 ubiquitin protein ligase 4 ISO CTD Direct Evidence: marker/mechanism CTD PMID:35713687 NCBI chr12:40,800,232...40,991,584
Ensembl chr12:35,182,154...35,330,987 		JBrowse link
G Hfe homeostatic iron regulator susceptibility ISO DNA:missense mutation:cds:p.H63D (human)
associated with cystic fibrosis;DNA:missense mutation: :p.C282Y (human)		 RGD PMID:20097100 PMID:30291871 RGD:8694381, RGD:14701045 NCBI chr17:41,841,302...41,849,359
Ensembl chr17:41,413,451...41,421,502 		JBrowse link
G Hhex hematopoietically expressed homeobox ISO CTD Direct Evidence: marker/mechanism CTD PMID:23104008 NCBI chr 1:244,602,945...244,608,532
Ensembl chr 1:235,190,455...235,196,042 		JBrowse link
G Hif1a hypoxia inducible factor 1 subunit alpha susceptibility IEP
ISO		 protein:increased expression:heart blood vessel
DNA:missense mutation:cds:p.P582S (human)
associated with Breast Neoplasms;protein:increased expression:serum (human)		 RGD PMID:12234789 PMID:16046581 PMID:23244125 PMID:17914354 RGD:625730, RGD:8695936, RGD:8695972, RGD:10395377 NCBI chr 6:98,357,788...98,405,068
Ensembl chr 6:92,624,390...92,669,261 		JBrowse link
G Hipk4 homeodomain interacting protein kinase 4 ISO ClinVar Annotator: match by term: Type 2 diabetes mellitus ClinVar PMID:28492532 NCBI chr 1:91,938,308...91,948,680
Ensembl chr 1:82,810,708...82,821,077 		JBrowse link
G Hk1 hexokinase 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:16123366 NCBI chr20:30,773,222...30,874,814
Ensembl chr20:30,230,486...30,332,131 		JBrowse link
G Hk2 hexokinase 2 ISO mRNA:decreased expression:epididymal fat pad, quadriceps RGD PMID:11319725 PMID:7813813 RGD:2313227, RGD:2313229 NCBI chr 4:116,792,258...116,841,275
Ensembl chr 4:115,234,509...115,283,530 		JBrowse link
G Hmg20a high mobility group 20A ISO CTD Direct Evidence: marker/mechanism CTD PMID:21874001 NCBI chr 8:65,715,688...65,791,663
Ensembl chr 8:56,819,659...56,895,656 		JBrowse link
G Hmga1 high mobility group AT-hook 1 susceptibility ISO
ISS		 CTD Direct Evidence: marker/mechanism
ClinVar Annotator: match by term: Diabetes mellitus type 2, susceptibility to
OMIM:125853 | OMIM:601283 | OMIM:601407 | OMIM:603694 | OMIM:608036		 CTD
ClinVar
OMIM
MouseDO		 PMID:15924147 PMID:21364139 PMID:23512162 NCBI chr20:5,612,902...5,620,596
Ensembl chr20:5,611,694...5,618,752 		JBrowse link
G Hmgcr 3-hydroxy-3-methylglutaryl-CoA reductase ISO
IMP		 DNA:polymorphism (human) RGD PMID:17870053 PMID:15312879 RGD:2313753, RGD:2313759 NCBI chr 2:29,732,163...29,754,276
Ensembl chr 2:27,997,525...28,019,703 		JBrowse link
G Hmox1 heme oxygenase 1 treatment ISO
IEP		 DNA:repeat:promoter
associated with Obesity
CTD Direct Evidence: marker/mechanism|therapeutic		 CTD
RGD		 PMID:12136229 PMID:16123366 PMID:16959961 PMID:17991645 PMID:23731386 RGD:10755699, RGD:8695927 NCBI chr19:13,452,365...13,479,823
Ensembl chr19:13,467,244...13,474,079 		JBrowse link
G Hnf1a HNF1 homeobox A susceptibility
onset		 ISO
ISS		 DNA:deletions:exon:multiple
Maturity-onset diabetes of the young type III, OMIM:600496;DNA:insertions, deletions, point mutations: :multiple
DNA:nonsense mutations, missense mutations: :multiple
DNA:SNP::rs1169288 associated with future risk of developing T2DM (p=0.0002) (human)
CTD Direct Evidence: marker/mechanism
ClinVar Annotator: match by term: Diabetes mellitus type 2, susceptibility to | ClinVar Annotator: match by term: Insulin-resistant diabetes mellitus | ClinVar Annotator: match by term: Type 2 diabetes mellitus
DNA:SNP:cds: p.G319S (human)
associated with nicotine dependence; DNA:SNP:cds: p.G319S (human)
OMIM:125853 | OMIM:601283 | OMIM:601407 | OMIM:603694 | OMIM:608036
ClinVar Annotator: match by term: DIABETES MELLITUS, TYPE 2, PROTECTION AGAINST | ClinVar Annotator: match by term: Insulin-resistant diabetes mellitus | ClinVar Annotator: match by term: Type 2 diabetes mellitus | ClinVar Annotator: match by term: Type II diabetes mellitus
ClinVar Annotator: match by term: DIABETES MELLITUS, TYPE 2, PROTECTION AGAINST | ClinVar Annotator: match by term: Diabetes mellitus type 2, susceptibility to | ClinVar Annotator: match by term: Diabetes mellitus, noninsulin-dependent, late onset | ClinVar Annotator: match by term: Insulin-resistant diabetes mellitus | ClinVar Annotator: match by term: Type 2 diabetes mellitus | ClinVar Annotator: match by term: Type II diabetes mellitus		 OMIM
CTD
ClinVar
MouseDO
RGD		 PMID:7842064 PMID:8945470 PMID:9075818 PMID:9112026 PMID:9133564 More... RGD:2301828, RGD:1601479, RGD:2301827, RGD:2301863, RGD:329901814, RGD:329901816, RGD:329901835 NCBI chr12:47,299,171...47,333,457
Ensembl chr12:41,645,587...41,672,104 		JBrowse link
G Hnf1b HNF1 homeobox B susceptibility
no_association		 ISO renal cysts and diabetes syndrome, OMIM:137920;DNA:splice-site mutation:intron:IVS2+1G>A
DNA:deletions:cds:multiple (human)
CTD Direct Evidence: marker/mechanism|therapeutic
ClinVar Annotator: match by term: Diabetes mellitus, noninsulin-dependent, late onset | ClinVar Annotator: match by term: Type 2 diabetes mellitus | ClinVar Annotator: match by term: Type II diabetes mellitus		 OMIM
CTD
ClinVar
RGD		 PMID:9398836 PMID:12148114 PMID:12161522 PMID:14583183 PMID:15068978 More... RGD:1601484, RGD:2312748, RGD:2312750 NCBI chr10:69,233,377...69,287,360
Ensembl chr10:68,735,894...68,789,888 		JBrowse link
G Hnf4a hepatocyte nuclear factor 4, alpha susceptibility ISO
IEP		 DNA:SNPs:promoter:(human)
type I maturity-onset diabetes of the young, OMIM:125850
DNA:missense mutation:exon:p.T130I
DNA:SNP::rs4810424 and rs3212198 nominally associated with future risk of developing T2DM (p=0.04) (human)
CTD Direct Evidence: marker/mechanism
protein:decreased expression:liver:
mRNA:decreased expression:liver,pancreas
ClinVar Annotator: match by term: Diabetes mellitus, noninsulin-dependent, late onset | ClinVar Annotator: match by term: Type 2 diabetes mellitus | ClinVar Annotator: match by term: Type II diabetes mellitus		 OMIM
CTD
ClinVar
RGD		 PMID:9449683 PMID:10227563 PMID:10447526 PMID:10983627 PMID:12627330 More... RGD:2301836, RGD:1601637, RGD:2301839, RGD:2301863, RGD:12904769, RGD:12904770 NCBI chr 3:172,606,220...172,667,758
Ensembl chr 3:152,186,787...152,248,320 		JBrowse link
G Hnrnpl heterogeneous nuclear ribonucleoprotein L ISO ClinVar Annotator: match by term: Type 2 diabetes mellitus ClinVar PMID:28492532 NCBI chr 1:93,226,373...93,239,084
Ensembl chr 1:84,100,879...84,111,553 		JBrowse link
G Hp haptoglobin treatment IEP
ISO		 CTD Direct Evidence: marker/mechanism CTD
RGD		 PMID:16506275 PMID:19996384 RGD:6483015 NCBI chr19:54,449,151...54,453,701
Ensembl chr19:37,539,627...37,544,523 		JBrowse link
G Hpx hemopexin ISO CTD Direct Evidence: marker/mechanism CTD PMID:16506275 NCBI chr 1:169,344,647...169,352,155
Ensembl chr 1:159,932,755...159,940,328 		JBrowse link
G Hsd11b1 hydroxysteroid 11-beta dehydrogenase 1 susceptibility IEP
ISO		 mRNA,protein:increased expression:islet cells:diabetic but not prediabetic Zucker Diabetic Fatty (fa/fa) rats
DNA:SNPs:intron: (rs12086634,rs846910) (human)		 RGD PMID:14697232 PMID:28750217 RGD:1625074, RGD:329901909 NCBI chr13:107,277,526...107,327,462
Ensembl chr13:104,728,539...104,788,687 		JBrowse link
G Hsd11b2 hydroxysteroid 11-beta dehydrogenase 2 ISO mRNA, protein:increased expression:skeletal muscle RGD PMID:17519316 RGD:2308922 NCBI chr19:50,307,569...50,312,812
Ensembl chr19:33,397,656...33,402,899 		JBrowse link
G Hsd17b3 hydroxysteroid (17-beta) dehydrogenase 3 IEP mRNA:decreased expression:testis, Leydig cell (rat) RGD PMID:18481435 RGD:4889107 NCBI chr17:1,032,958...1,064,283
Ensembl chr17:1,027,229...1,058,554 		JBrowse link
G Hsd3b1 hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 1 IEP mRNA:decreased expression:testis, Leydig cell (rat) RGD PMID:18481435 RGD:4889107 NCBI chr 2:188,858,574...188,864,694
Ensembl chr 2:186,169,863...186,175,999 		JBrowse link
G Hsf1 heat shock transcription factor 1 ISO protein:increased expression:heart (mouse) RGD PMID:24496227 RGD:10402557 NCBI chr 7:110,076,710...110,103,665
Ensembl chr 7:108,196,056...108,223,011 		JBrowse link
G Hspa1b heat shock protein family A (Hsp70) member 1B ISO DNA:SNP:CDS:homozygous P2/P2 allele at position 1267 (p=0.001 for all diabetic p RGD PMID:15223990 RGD:1626646 NCBI chr20:3,859,756...3,863,800
Ensembl chr20:3,856,006...3,873,240
Ensembl chr20:3,856,006...3,873,240 		JBrowse link
G Hspa4 heat shock protein family A (Hsp70) member 4 ISO protein:increased expression:serum (human) RGD PMID:22349026 RGD:6218966 NCBI chr10:37,908,866...37,951,994
Ensembl chr10:37,408,025...37,449,001 		JBrowse link
G Htr2c 5-hydroxytryptamine receptor 2C ISS OMIM:125853 | OMIM:601283 | OMIM:601407 | OMIM:603694 | OMIM:608036 MouseDO NCBI chr  X:115,453,190...115,682,325
Ensembl chr  X:110,641,153...110,870,287 		JBrowse link
G Iapp islet amyloid polypeptide ISO
ISS		 protein:increased expression:pancreatic islet (human)
CTD Direct Evidence: marker/mechanism
OMIM:125853 | OMIM:601283 | OMIM:601407 | OMIM:603694 | OMIM:608036		 CTD
MouseDO
RGD		 PMID:16123366 PMID:23793354 PMID:18641056 PMID:2441214 PMID:19100955 RGD:2313359, RGD:9686128, RGD:2311446 NCBI chr 4:176,968,097...176,975,363
Ensembl chr 4:175,237,115...175,242,920 		JBrowse link
G Icam1 intercellular adhesion molecule 1 IEP
ISO		 mRNA, protein:increased expression:aorta (rat)
protein:increased expression:plasma
CTD Direct Evidence: marker/mechanism		 CTD
RGD		 PMID:24513509 PMID:20388520 PMID:18299691 RGD:4145422, RGD:2312766 NCBI chr 8:27,829,688...27,841,618
Ensembl chr 8:19,553,645...19,565,438 		JBrowse link
G Id1 inhibitor of DNA binding 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:16123366 NCBI chr 3:161,671,525...161,672,691
Ensembl chr 3:141,211,267...141,212,419 		JBrowse link
G Ide insulin degrading enzyme no_association ISO
IAGP		 DNA:SNPs, haplotype: :rs2209972, rs1887922 (human)
DNA:missense mutations, haplotype:exon:p.H18R, p.A890V (rat)
DNA:SNP:cds (rs6583813) (human)		 RGD PMID:12765971 PMID:16380485 PMID:12634421 PMID:10958757 PMID:23776430 RGD:1626697, RGD:1626698, RGD:737718, RGD:737717, RGD:405650683 NCBI chr 1:244,415,495...244,516,925
Ensembl chr 1:234,995,351...235,102,440 		JBrowse link
G Ifng interferon gamma ISO RGD PMID:18852529 RGD:2311491 NCBI chr 7:55,789,180...55,793,216
Ensembl chr 7:53,903,337...53,907,375 		JBrowse link
G Ifnl1 interferon, lambda 1 ISO ClinVar Annotator: match by term: Type 2 diabetes mellitus ClinVar PMID:28492532 NCBI chr 1:92,926,184...92,927,830
Ensembl chr 1:83,798,703...83,800,235 		JBrowse link
G Ifnl3 interferon, lambda 3 ISO ClinVar Annotator: match by term: Type 2 diabetes mellitus ClinVar PMID:28492532 NCBI chr 1:92,941,988...92,943,628
Ensembl chr 1:83,814,564...83,816,096 		JBrowse link
G Igf1 insulin-like growth factor 1 IEP
ISO		 RGD PMID:18986336 PMID:16005252 RGD:2306690, RGD:2313767 NCBI chr 7:24,169,608...24,249,446
Ensembl chr 7:22,282,930...22,359,296 		JBrowse link
G Igf1r insulin-like growth factor 1 receptor IEP protein:decreased expression:pancreas
protein:decreased expression:myocardium, blood vessel endothelial cell		 RGD PMID:17476475 PMID:18986336 RGD:2311504, RGD:2306690 NCBI chr 1:130,959,787...131,248,664
Ensembl chr 1:121,550,743...121,831,777 		JBrowse link
G Igf2 insulin-like growth factor 2 IEP
ISO		 protein:decreased expression:pancreas RGD PMID:17476475 PMID:10727441 RGD:2311504, RGD:5510004 NCBI chr 1:207,243,873...207,261,263
Ensembl chr 1:197,814,410...197,823,018 		JBrowse link
G Igf2bp2 insulin-like growth factor 2 mRNA binding protein 2 susceptibility ISO ClinVar Annotator: match by term: Diabetes mellitus type 2, susceptibility to
CTD Direct Evidence: marker/mechanism		 ClinVar
OMIM
CTD		 PMID:17463246 PMID:17463248 PMID:17463249 NCBI chr11:92,378,908...92,478,893
Ensembl chr11:78,874,414...78,974,377 		JBrowse link
G Igf2r insulin-like growth factor 2 receptor susceptibility ISO DNA:insertion, deletion:3' utr (human) RGD PMID:16868148 RGD:2311514 NCBI chr 1:50,526,878...50,615,265
Ensembl chr 1:47,979,109...48,067,501 		JBrowse link
G Igfbp3 insulin-like growth factor binding protein 3 ISO RGD PMID:16005252 RGD:2313767 NCBI chr14:86,270,208...86,277,944
Ensembl chr14:82,056,347...82,064,083 		JBrowse link
G Ikbkb inhibitor of nuclear factor kappa B kinase subunit beta ISO RGD PMID:15685173 RGD:10045952 NCBI chr16:76,021,968...76,075,717
Ensembl chr16:69,319,554...69,373,250 		JBrowse link
G Il10 interleukin 10 susceptibility ISO DNA:polymorphisms:promoter:g.-1082G>A, g.-819C>T, g.-592C>A (human) RGD PMID:19031431 PMID:28843383 RGD:2308943, RGD:14975146 NCBI chr13:45,024,921...45,029,586
Ensembl chr13:42,472,839...42,477,313 		JBrowse link
G Il13ra1 interleukin 13 receptor subunit alpha 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:30718926 NCBI chr  X:120,213,670...120,294,777
Ensembl chr  X:115,348,860...115,408,681
Ensembl chr11:115,348,860...115,408,681 		JBrowse link
G Il1b interleukin 1 beta susceptibility ISO DNA:snp:exon:g.3968C>T rs1143634 (human) RGD PMID:21205020 PMID:28843383 RGD:7175255, RGD:14975146 NCBI chr 3:137,030,200...137,036,581
Ensembl chr 3:116,577,010...116,583,415 		JBrowse link
G Il1rn interleukin 1 receptor antagonist susceptibility
no_association
disease_progression		 ISO DNA:repeats:intron:IVS2+914_1000dup IL1RN*2, IL1RN*3 (human)
DNA:repeats:intron:IVS2+914_1000dup IL1RN*2 (human)
associated with Metabolic Syndrome X; DNA:snp:intron:IVS3+102A>G rs3213448 (human)		 RGD PMID:17069782 PMID:8786086 PMID:21205020 RGD:6907409, RGD:6907412, RGD:7175255 NCBI chr 3:27,509,836...27,525,738
Ensembl chr 3:7,111,550...7,127,445 		JBrowse link
G Il6 interleukin 6 susceptibility IEP
ISO		 mRNA:increased expression:adipose tissue
DNA:polymorphism:promoter:-572C>G (human)
protein:increased expression:extracellular space (human)
DNA, protein:SNP, increased expression:promoter:serum, -174G>C (human)
CTD Direct Evidence: marker/mechanism
ClinVar Annotator: match by term: Diabetes mellitus type 2, susceptibility to		 CTD
ClinVar
OMIM
RGD		 PMID:9769329 PMID:10720087 PMID:11001912 PMID:11889177 PMID:12519862 More... RGD:2307269, RGD:2307270, RGD:2307266, RGD:14975285 NCBI chr 4:5,889,999...5,894,575
Ensembl chr 4:5,213,394...5,219,178 		JBrowse link
G Inppl1 inositol polyphosphate phosphatase-like 1 ISO DNA:SNPs: :rs2276047,snp8(human)
DNA:deletion:3' utr (human)
CTD Direct Evidence: marker/mechanism		 CTD
RGD		 PMID:12086927 PMID:25635986 PMID:15220217 PMID:12086927 RGD:1626127, RGD:633161 NCBI chr 1:165,595,047...165,609,503
Ensembl chr 1:156,183,059...156,197,500 		JBrowse link
G Ins1 insulin 1 ISO CTD Direct Evidence: marker/mechanism
ClinVar Annotator: match by term: Type 2 diabetes mellitus		 CTD
ClinVar		 PMID:17047922 PMID:17855560 PMID:18162506 PMID:18171712 PMID:19586609 More... NCBI chr 1:261,186,119...261,186,686
Ensembl chr 1:251,244,973...251,245,536 		JBrowse link
G Ins2 insulin 2 ISO
ISS		 CTD Direct Evidence: marker/mechanism|therapeutic
OMIM:125853 | OMIM:601283 | OMIM:601407 | OMIM:603694 | OMIM:608036
ClinVar Annotator: match by term: Type 2 diabetes mellitus		 CTD
MouseDO
ClinVar
RGD		 PMID:3511099 PMID:7573102 PMID:11522680 PMID:11978674 PMID:15531508 More... RGD:1625120, RGD:2311112 NCBI chr 1:207,272,738...207,421,998
Ensembl chr 1:197,843,281...197,864,775 		JBrowse link
G Insr insulin receptor treatment ISO
IDA
IMP
IEP		 protein:increased serine phosphorylation, increased protein binding:liver
protein:decreased expression:kidney
protein:decreased phosphorylation:vastus lateralis:phosphotyrosine (human)
ClinVar Annotator: match by term: Insulin-resistant diabetes mellitus | ClinVar Annotator: match by term: Type 2 diabetes mellitus		 ClinVar
RGD		 PMID:1607076 PMID:1845971 PMID:2040394 PMID:2884728 PMID:4413914 More... RGD:2307334, RGD:2307334, RGD:2307333, RGD:2307341, RGD:2307335, RGD:2290475, RGD:2307342, RGD:10403046, RGD:2314405 NCBI chr12:5,991,135...6,129,275
Ensembl chr12:1,197,100...1,330,883 		JBrowse link
G Irs1 insulin receptor substrate 1 no_association
susceptibility		 ISO
IDA
ISS		 DNA:point mutation:exon:T608R
DNA:polymorphisms: :p.P512A, p.G971R (human)
DNA:SNP:promoter:-446G>A, -7120G>A (human)
CTD Direct Evidence: marker/mechanism
ClinVar Annotator: match by term: IRS1-related condition | ClinVar Annotator: match by term: Type 2 diabetes mellitus
OMIM:125853 | OMIM:601283 | OMIM:601407 | OMIM:603694 | OMIM:608036		 CTD
ClinVar
MouseDO
OMIM
RGD		 PMID:8104271 PMID:8723689 PMID:10430617 PMID:11775217 PMID:12679424 More... RGD:1624975, RGD:6482863, RGD:6483015, RGD:6483016, RGD:7207057 NCBI chr 9:91,001,137...91,053,959
Ensembl chr 9:83,548,944...83,606,122 		JBrowse link
G Irs2 insulin receptor substrate 2 ISO
ISS		 DNA:polymorphism:exon:G1057D
CTD Direct Evidence: marker/mechanism
OMIM:125853 | OMIM:601283 | OMIM:601407 | OMIM:603694 | OMIM:608036
ClinVar Annotator: match by term: IRS2-related condition | ClinVar Annotator: match by term: Type 2 diabetes mellitus		 OMIM
CTD
MouseDO
ClinVar
RGD		 PMID:10525667 PMID:11030756 PMID:11473060 PMID:11600548 PMID:25741868 More... RGD:1625023, RGD:10045938 NCBI chr16:85,190,310...85,214,543
Ensembl chr16:78,485,045...78,512,482 		JBrowse link
G Isl1 ISL LIM homeobox 1 ISO
IEP		 associated with Obesity;DNA:SNP:promoter:g.-47A>G (human)
mRNA,protein:decreased expression:pancreas:		 RGD PMID:11978668 PMID:30341898 RGD:2311117, RGD:243065124 NCBI chr 2:49,813,618...49,823,442
Ensembl chr 2:48,080,522...48,095,584 		JBrowse link
G Itga1 integrin subunit alpha 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:30718926 NCBI chr 2:48,379,181...48,545,336
Ensembl chr 2:46,653,193...46,812,238 		JBrowse link
G Itga2 integrin subunit alpha 2 ISO protein:increased expression:platelet (human) RGD PMID:15025679 RGD:2307425 NCBI chr 2:48,253,412...48,354,509
Ensembl chr 2:46,523,948...46,621,481 		JBrowse link
G Itgam integrin subunit alpha M IEP protein:increased expression:neutrophil (rat) RGD PMID:21699626 RGD:329902064 NCBI chr 1:192,089,496...192,139,947
Ensembl chr 1:182,659,000...182,709,503 		JBrowse link
G Itln1 intelectin 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:23555749 NCBI chr13:86,464,641...86,490,655
Ensembl chr13:83,948,124...83,958,227 		JBrowse link
G Jade2 jade family PHD finger 2 ISO CTD Direct Evidence: marker/mechanism CTD PMID:28869590 NCBI chr10:36,576,187...36,625,129
Ensembl chr10:36,078,917...36,116,984 		JBrowse link
G Jazf1 JAZF zinc finger 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:18372903 NCBI chr 4:83,210,054...83,513,790
Ensembl chr 4:81,881,061...82,183,100 		JBrowse link
G Kcnj11 potassium inwardly-rectifying channel, subfamily J, member 11 ISO
IEP		 polymorphisms in the human gene are linked to altered insulin secretion; E23K polymorphism appears to confer susceptibility to diabetes type-2 in Caucasian population
DNA:polymorphism: :p.E23K (human)
DNA:SNP
DNA:missense mutation::p.E23K (human)
CTD Direct Evidence: marker/mechanism
mRNA:increased expression:heart
ClinVar Annotator: match by term: Diabetes Mellitus, Noninsulin-Dependent, with Acanthosis Nigricans and Hypertension | ClinVar Annotator: match by term: Diabetes mellitus, noninsulin-dependent, late onset | ClinVar Annotator: match by term: Type 2 diabetes mellitus
ClinVar Annotator: match by term: Diabetes mellitus, noninsulin-dependent, late onset | ClinVar Annotator: match by term: Type 2 diabetes mellitus | ClinVar Annotator: match by term: Type II diabetes mellitus
ClinVar Annotator: match by term: Diabetes Mellitus, Noninsulin-Dependent, with Acanthosis Nigricans and Hypertension | ClinVar Annotator: match by term: Diabetes mellitus, noninsulin-dependent, late onset | ClinVar Annotator: match by term: Type 2 diabetes mellitus | ClinVar Annotator: match by term: Type II diabetes mellitus		 CTD
ClinVar
RGD		 PMID:1422196 PMID:9867219 PMID:10559219 PMID:11318841 PMID:11395395 More... RGD:2313610, RGD:2311534, RGD:2311533, RGD:2313628, RGD:12790969 NCBI chr 1:105,727,473...105,731,167
Ensembl chr 1:96,591,049...96,594,082 		JBrowse link
G Kcnk16 potassium two pore domain channel subfamily K member 16 ISO CTD Direct Evidence: marker/mechanism CTD PMID:22158537 NCBI chr15:4,069,495...4,098,836
Ensembl chr15:4,042,506...4,049,652 		JBrowse link
G Kcnmb1 potassium calcium-activated channel subfamily M regulatory beta subunit 1 IEP protein:decreased expression:aorta RGD PMID:18790848 RGD:10412045 NCBI chr10:19,062,014...19,119,005
Ensembl chr10:18,557,904...18,565,798 		JBrowse link
G Kcnn4 potassium calcium-activated channel subfamily N member 4 IEP protein:increased expression:aorta (rat) RGD PMID:21463632 RGD:401794561 NCBI chr 1:89,084,306...89,102,279
Ensembl chr 1:79,959,322...79,974,340 		JBrowse link
G Kcnq1 potassium voltage-gated channel subfamily Q member 1 susceptibility ISO CTD Direct Evidence: marker/mechanism
associated with Environmental Illness; DNA:SNP:: (rs163184) (human)		 CTD
RGD		 PMID:18711366 PMID:18711367 PMID:26551672 PMID:27281273 RGD:401850598 NCBI chr 1:207,721,134...208,054,073
Ensembl chr 1:198,291,766...198,624,669 		JBrowse link
G Kcnu1 potassium calcium-activated channel subfamily U member 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:28869590 NCBI chr16:72,844,692...72,932,216
Ensembl chr16:66,141,976...66,229,465 		JBrowse link
G Kdr kinase insert domain receptor ISO protein:decreased expression:skin, blood vessel RGD PMID:17898089 RGD:5684411 NCBI chr14:32,572,031...32,615,204
Ensembl chr14:32,217,871...32,261,018 		JBrowse link
G Kif6 kinesin family member 6 sexual_dimorphism ISO DNA:SNP: :p.W719R (rs20455) (human) RGD PMID:25629058 RGD:243048454 NCBI chr 9:18,573,925...18,870,789
Ensembl chr 9:11,072,824...11,373,006 		JBrowse link
G Kl Klotho IEP
ISO		 mRNA:decreased expression:kidney:
CTD Direct Evidence: marker/mechanism		 CTD
RGD		 PMID:28869590 PMID:23967103 RGD:10044235 NCBI chr12:5,326,003...5,367,016
Ensembl chr12:490,399...530,080 		JBrowse link
G Klf11 KLF transcription factor 11 ISO DNA:polymorphisms: :p.Q62R, p.A347S, p.T220M (human)
ClinVar Annotator: match by term: Type 2 diabetes mellitus		 ClinVar
RGD		 PMID:15774581 PMID:18199129 PMID:25741868 PMID:28492532 PMID:34393998 More... RGD:2311540 NCBI chr 6:47,014,312...47,026,152
Ensembl chr 6:41,285,842...41,297,550 		JBrowse link
G Klf14 KLF transcription factor 14 ISO CTD Direct Evidence: marker/mechanism CTD PMID:29632379 NCBI chr 4:60,521,363...60,524,285
Ensembl chr 4:59,554,011...59,556,933 		JBrowse link
G Kmt2d lysine methyltransferase 2D ISO RGD PMID:23826075 RGD:9588237 NCBI chr 7:131,859,696...131,901,032
Ensembl chr 7:129,962,887...130,020,325 		JBrowse link
G Ksr2 kinase suppressor of ras 2 ISO CTD Direct Evidence: marker/mechanism
ClinVar Annotator: match by term: Type 2 diabetes mellitus		 CTD
ClinVar		 PMID:24209692 PMID:25741868 PMID:30718926 NCBI chr12:44,462,579...44,848,555
Ensembl chr12:38,802,004...39,188,375 		JBrowse link
G Lcn2 lipocalin 2 ISO protein:increased expression:serum: RGD PMID:19949414 RGD:126779589 NCBI chr 3:36,078,432...36,081,851
Ensembl chr 3:15,680,687...15,684,095 		JBrowse link
G Lep leptin susceptibility IMP
ISO
ISS		 CTD Direct Evidence: therapeutic
DNA:SNP,haplotype:promoter,3'utr: -632G>A, +4998A>C (human)
OMIM:125853 | OMIM:601283 | OMIM:601407 | OMIM:603694 | OMIM:608036		 CTD
MouseDO
RGD		 PMID:15070752 PMID:19289493 PMID:18564365 RGD:2311130, RGD:2311139 NCBI chr 4:58,626,529...58,640,663
Ensembl chr 4:57,661,131...57,675,262 		JBrowse link
G Lepr leptin receptor susceptibility
treatment		 ISO
IAGP
ISS		 DNA:insertion:3' utr (human)
DNA:polymorphisms (human)
associated with nonalcoholic fatty liver disease;DNA:intron:c.2673+1118C>T (rs6700896) (human)
OMIM:125853 | OMIM:601283 | OMIM:601407 | OMIM:603694 | OMIM:608036
DNA:mutations:cds: : (rat)
CTD Direct Evidence: marker/mechanism		 MouseDO
CTD
RGD		 PMID:20175764 PMID:22933112 PMID:24263156 PMID:26939912 PMID:39059604 More... RGD:2311144, RGD:2311141, RGD:10412018, RGD:13432147, RGD:14696694, RGD:401960103 NCBI chr 5:121,409,735...121,593,201
Ensembl chr 5:116,289,823...116,475,908 		JBrowse link
G Leprfa leptin receptor; fa mutant IAGP RGD PMID:23154293 RGD:13432147
G Lgals4 galectin 4 ISO ClinVar Annotator: match by term: Type 2 diabetes mellitus ClinVar PMID:28492532 NCBI chr 1:93,248,463...93,260,002
Ensembl chr 1:84,124,764...84,132,481 		JBrowse link
G Lgals5 galectin 5 ISO ClinVar Annotator: match by term: Type 2 diabetes mellitus ClinVar PMID:28492532 NCBI chr10:64,351,976...64,355,137
Ensembl chr10:63,853,935...63,857,153 		JBrowse link
G Lgals7 galectin 7 ISO ClinVar Annotator: match by term: Type 2 diabetes mellitus ClinVar PMID:28492532 NCBI chr 1:93,275,092...93,279,529
Ensembl chr 1:84,150,252...84,152,015 		JBrowse link
G Lipc lipase C, hepatic type susceptibility ISO DNA:transition:promoter:-250G>A (human)
protein:increased expression:plasma (human)
CTD Direct Evidence: marker/mechanism
ClinVar Annotator: match by term: Diabetes mellitus type 2, susceptibility to | ClinVar Annotator: match by term: Type 2 diabetes mellitus		 OMIM
CTD
ClinVar
RGD		 PMID:1671786 PMID:1883393 PMID:8123642 PMID:8732782 PMID:12777476 More... RGD:2308830, RGD:2308826 NCBI chr 8:80,390,470...80,516,463
Ensembl chr 8:71,509,635...71,635,464 		JBrowse link
G Lipe lipase E, hormone sensitive type ISO mRNA:decreased expression:subcutaneous adipose tissue RGD PMID:15609025 RGD:2313584 NCBI chr 1:90,093,433...90,112,117
Ensembl chr 1:80,965,627...80,984,310 		JBrowse link
G Lmna lamin A/C no_association ISO DNA:SNPs RGD PMID:17327461 PMID:17327437 RGD:1624984, RGD:1624985 NCBI chr 2:176,237,564...176,265,301
Ensembl chr 2:173,939,751...173,960,423 		JBrowse link
G Lnpep leucyl and cystinyl aminopeptidase ISO
IDA		 RGD PMID:11701721 PMID:16967782 RGD:2311542, RGD:2306436 NCBI chr 1:66,931,712...67,027,610
Ensembl chr 1:58,258,642...58,354,544 		JBrowse link
G Lpl lipoprotein lipase treatment ISO
IEP		 associated with Obesity
DNA:SNP:intron:13836C>A (rs343) (human)		 RGD PMID:8641022 PMID:18321693 PMID:18985010 PMID:29981201 RGD:1580537, RGD:2313304, RGD:2313298, RGD:13793399 NCBI chr16:25,596,205...25,621,928
Ensembl chr16:20,829,465...20,855,249 		JBrowse link
G Lrfn1 leucine rich repeat and fibronectin type III domain containing 1 ISO ClinVar Annotator: match by term: Type 2 diabetes mellitus ClinVar PMID:28492532 NCBI chr 1:92,866,864...92,888,984
Ensembl chr 1:83,682,964...83,761,449 		JBrowse link
G Lta lymphotoxin alpha onset
no_association		 ISO DNA:polymorphism: :p.T60N (human) RGD PMID:15729581 PMID:16132956 RGD:1625033, RGD:2313261 NCBI chr20:3,622,291...3,625,852
Ensembl chr20:3,618,853...3,620,859 		JBrowse link
G Madd MAP-kinase activating death domain ISS OMIM:125853 | OMIM:601283 | OMIM:601407 | OMIM:603694 | OMIM:608036 MouseDO NCBI chr 3:97,570,141...97,613,688
Ensembl chr 3:77,114,314...77,157,701 		JBrowse link
G Maea macrophage erythroblast attacher, E3 ubiquitin ligase ISO CTD Direct Evidence: marker/mechanism CTD PMID:22158537 NCBI chr14:81,581,784...81,615,246
Ensembl chr14:77,357,264...77,390,671 		JBrowse link
G Mafa MAF bZIP transcription factor A ISO
ISS		 protein:decreased expression:islet:
protein:decreased expression:beta cells of pancrea
OMIM:125853 | OMIM:601283 | OMIM:601407 | OMIM:603694 | OMIM:608036		 MouseDO
RGD		 PMID:24013263 PMID:20424231 RGD:13506742, RGD:13506745 NCBI chr 7:109,313,021...109,315,813
Ensembl chr 7:107,433,605...107,434,690 		JBrowse link
G Map1lc3a microtubule-associated protein 1 light chain 3 alpha treatment IEP RGD PMID:21820301 RGD:11561956 NCBI chr 3:164,243,204...164,244,850
Ensembl chr 3:143,783,024...143,784,670 		JBrowse link
G Map3k10 mitogen activated protein kinase kinase kinase 10 ISO ClinVar Annotator: match by term: Type 2 diabetes mellitus ClinVar PMID:28492532 NCBI chr 1:92,083,376...92,101,676
Ensembl chr 1:82,955,207...82,974,084 		JBrowse link
G Map3k8 mitogen-activated protein kinase kinase kinase 8 ISO protein:increased activity:serum: RGD PMID:28724746 RGD:151356966 NCBI chr17:58,078,175...58,098,455
Ensembl chr17:53,383,131...53,403,216 		JBrowse link
G Mapk1 mitogen activated protein kinase 1 treatment ISO
IDA		 protein:hyperphosphorylation:pancreas:
protein:increased expression:dorsal horn:
protein:hypophosphorylation:pancreatic islet:		 RGD PMID:26860984 PMID:27259299 PMID:28757391 PMID:21911753 PMID:19164460 RGD:13506775, RGD:13506776, RGD:13506777, RGD:13506785, RGD:13506786 NCBI chr11:97,462,025...97,529,193
Ensembl chr11:83,957,813...84,023,616 		JBrowse link
G Mapk3 mitogen activated protein kinase 3 treatment IDA
ISO		 protein:hypophosphorylation:pancreatic islet:
protein:hyperphosphorylation:pancreas:
protein:increased expression:dorsal horn:		 RGD PMID:21911753 PMID:26860984 PMID:27259299 PMID:28757391 PMID:19164460 RGD:13506785, RGD:13506775, RGD:13506776, RGD:13506777, RGD:13506786 NCBI chr 1:190,797,189...190,803,411
Ensembl chr 1:181,366,637...181,372,863 		JBrowse link
G Mapk8 mitogen-activated protein kinase 8 IDA
ISO		 protein:hyperphosphorylation:pancreatic islet: RGD PMID:21911753 PMID:21911753 RGD:13506785, RGD:13506785 NCBI chr16:8,645,171...8,728,225
Ensembl chr16:8,638,924...8,721,981 		JBrowse link
G Mapk8ip1 mitogen-activated protein kinase 8 interacting protein 1 ISO ClinVar Annotator: match by term: Diabetes mellitus type 2, susceptibility to | ClinVar Annotator: match by term: Type 2 diabetes mellitus
CTD Direct Evidence: marker/mechanism		 OMIM
ClinVar
CTD		 PMID:10700186 NCBI chr 3:98,810,540...98,829,302
Ensembl chr 3:78,355,048...78,372,884 		JBrowse link
G Mapk9 mitogen-activated protein kinase 9 IDA
ISO		 protein:hyperphosphorylation:pancreatic islet: RGD PMID:21911753 PMID:21911753 RGD:13506785, RGD:13506785 NCBI chr10:34,670,750...34,711,972
Ensembl chr10:34,169,675...34,210,178 		JBrowse link
G Mat1a methionine adenosyltransferase 1A ISO CTD Direct Evidence: marker/mechanism CTD PMID:23665415 NCBI chr16:17,017,168...17,035,368
Ensembl chr16:16,983,022...17,001,274 		JBrowse link
G Matn4 matrilin 4 ISO ClinVar Annotator: match by term: Type 2 diabetes mellitus ClinVar NCBI chr 3:173,539,966...173,554,984
Ensembl chr 3:153,120,632...153,135,865 		JBrowse link
G Med29 mediator complex subunit 29 ISO ClinVar Annotator: match by term: Type 2 diabetes mellitus ClinVar PMID:28492532 NCBI chr 1:92,805,505...92,810,908
Ensembl chr 1:83,677,961...83,683,365 		JBrowse link
G Mfn2 mitofusin 2 ISO mRNA:decreased expression:skeletal muscle tissue (human) RGD PMID:16123358 RGD:13204820 NCBI chr 5:163,587,463...163,617,363
Ensembl chr 5:158,304,287...158,335,342 		JBrowse link
G Mif macrophage migration inhibitory factor IEP mRNA, protein:increased expression:kidney cortex, epithelial cell RGD PMID:16571782 RGD:1641984 NCBI chr20:12,767,138...12,791,222
Ensembl chr20:12,790,902...12,799,504
Ensembl chr 4:12,790,902...12,799,504 		JBrowse link
G Mir10b microRNA 10b ISO CTD Direct Evidence: marker/mechanism CTD PMID:28545106 NCBI chr 3:80,035,859...80,035,967
Ensembl chr 3:59,628,438...59,628,546 		JBrowse link
G Mir122 microRNA 122 ISO miRNA:increased expression:serum RGD PMID:27899485 RGD:14401601 NCBI chr18:61,028,817...61,028,901 JBrowse link
G Mir1249 microRNA 1249 ISO CTD Direct Evidence: marker/mechanism CTD PMID:28545106 NCBI chr 7:117,955,517...117,955,636
Ensembl chr 7:116,075,593...116,075,712 		JBrowse link
G Mir125b1 microRNA 125b-1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:24478399 NCBI chr 8:50,850,036...50,850,122
Ensembl chr 8:41,952,966...41,953,052 		JBrowse link
G Mir126a microRNA 126a ISO CTD Direct Evidence: marker/mechanism CTD PMID:24478399 NCBI chr 3:29,813,150...29,813,267
Ensembl chr 3:9,415,063...9,415,180 		JBrowse link
G Mir127 microRNA 127 ISO CTD Direct Evidence: marker/mechanism CTD PMID:28545106 NCBI chr 6:134,328,454...134,328,550
Ensembl chr 6:128,546,215...128,546,311 		JBrowse link
G Mir1306 microRNA 1306 ISO CTD Direct Evidence: marker/mechanism CTD PMID:28545106 NCBI chr11:96,213,960...96,214,032
Ensembl chr11:82,709,637...82,709,719 		JBrowse link
G Mir130b microRNA 130b ISO CTD Direct Evidence: marker/mechanism CTD PMID:24478399 NCBI chr11:97,384,380...97,384,461
Ensembl chr11:83,880,163...83,880,244 		JBrowse link
G Mir140 microRNA 140 ISO CTD Direct Evidence: marker/mechanism CTD PMID:24478399 NCBI chr19:52,375,293...52,375,391
Ensembl chr19:35,465,577...35,465,675 		JBrowse link
G Mir141 microRNA 141 ISO CTD Direct Evidence: marker/mechanism CTD PMID:28545106 NCBI chr 4:159,209,525...159,209,618
Ensembl chr 4:157,523,239...157,523,332 		JBrowse link
G Mir142 microRNA 142 ISO CTD Direct Evidence: marker/mechanism CTD PMID:24478399 NCBI chr10:73,055,104...73,055,190
Ensembl chr10:72,557,857...72,557,967 		JBrowse link
G Mir144 microRNA 144 ISO CTD Direct Evidence: marker/mechanism CTD PMID:28545106 NCBI chr10:63,459,397...63,459,479
Ensembl chr10:62,961,348...62,961,430 		JBrowse link
G Mir146b microRNA 146b ISO RNA:increased expression:arteriole RGD PMID:29374012 RGD:13702880 NCBI chr 1:255,144,860...255,144,947
Ensembl chr 1:245,203,438...245,203,525 		JBrowse link
G Mir151 microRNA 151 ISO CTD Direct Evidence: marker/mechanism CTD PMID:28545106 NCBI chr 7:107,061,380...107,061,476 JBrowse link
G Mir155 microRNA 155 ISO miRNA:decreased expression:serum RGD PMID:30852102 PMID:27711113 RGD:21079478, RGD:25671464 NCBI chr11:37,261,114...37,261,178
Ensembl chr11:23,774,654...23,774,718 		JBrowse link
G Mir181c microRNA 181c ISO CTD Direct Evidence: marker/mechanism CTD PMID:28545106 NCBI chr19:40,888,291...40,888,396
Ensembl chr19:23,983,523...23,983,628 		JBrowse link
G Mir192 microRNA 192 ISO CTD Direct Evidence: marker/mechanism CTD PMID:24478399 NCBI chr 1:212,994,209...212,994,318
Ensembl chr 1:203,564,946...203,565,055 		JBrowse link
G Mir195 microRNA 195 ISO CTD Direct Evidence: marker/mechanism CTD PMID:24478399 NCBI chr10:55,450,495...55,450,581
Ensembl chr10:54,951,838...54,951,924 		JBrowse link
G Mir200a microRNA 200a ISO CTD Direct Evidence: marker/mechanism CTD PMID:28545106 NCBI chr 5:171,930,717...171,930,805 JBrowse link
G Mir204 microRNA 204 ISO CTD Direct Evidence: marker/mechanism CTD PMID:28545106 NCBI chr 1:229,743,461...229,743,570
Ensembl chr 1:220,316,931...220,317,040 		JBrowse link
G Mir205 microRNA 205 ISO CTD Direct Evidence: marker/mechanism CTD PMID:28545106 NCBI chr13:107,564,535...107,564,642
Ensembl chr13:105,035,878...105,035,985 		JBrowse link
G Mir214 microRNA 214 ISO CTD Direct Evidence: marker/mechanism CTD PMID:28545106 NCBI chr13:77,121,645...77,121,752
Ensembl chr13:74,588,372...74,588,481 		JBrowse link
G Mir221 microRNA 221 ISO CTD Direct Evidence: marker/mechanism CTD PMID:28545106 NCBI chr  X:6,023,182...6,023,290
Ensembl chr  X:3,429,465...3,429,573 		JBrowse link
G Mir222 microRNA 222 ISO
IEP		 CTD Direct Evidence: marker/mechanism
associated with Femoral Fractures;RNA:increased expression:femur		 CTD
RGD		 PMID:24478399 PMID:28545106 PMID:31691506 RGD:151893486 NCBI chr  X:6,022,621...6,022,723
Ensembl chr  X:3,428,904...3,429,006 		JBrowse link
G Mir223 microRNA 223 severity ISO RNA:increased expression:pancreatic islet RGD PMID:31118273 PMID:31118273 RGD:25823139, RGD:25823139 NCBI chr  X:65,151,383...65,151,492
Ensembl chr  X:61,141,887...61,141,996 		JBrowse link
G Mir27a microRNA 27a ISO CTD Direct Evidence: marker/mechanism CTD PMID:28545106 NCBI chr19:40,859,603...40,859,689
Ensembl chr19:23,954,831...23,954,917 		JBrowse link
G Mir29a microRNA 29a ISO RNA:increased expression:arteriole
RNA:incrased expression:blood serum (human)		 RGD PMID:29374012 PMID:33116722 RGD:13702880, RGD:243048436 NCBI chr 4:60,617,955...60,618,042 JBrowse link
G Mir29b1 microRNA 29b-1 ISO RNA:increased expression:arteriole
RNA:increased expression:blood serum (human)		 RGD PMID:29374012 PMID:33116722 RGD:13702880, RGD:243048436 NCBI chr 4:60,618,334...60,618,414
Ensembl chr 4:59,650,986...59,651,067 		JBrowse link
G Mir30a microRNA 30a ISO CTD Direct Evidence: marker/mechanism CTD PMID:28545106 NCBI chr 9:33,233,941...33,234,011
Ensembl chr 9:25,737,600...25,737,670 		JBrowse link
G Mir339 microRNA 339 ISO CTD Direct Evidence: marker/mechanism CTD PMID:28545106 NCBI chr12:20,391,395...20,391,490
Ensembl chr12:15,277,546...15,277,641 		JBrowse link
G Mir375 microRNA 375 ISO CTD Direct Evidence: marker/mechanism CTD PMID:28545106 NCBI chr 9:83,906,582...83,906,656
Ensembl chr 9:76,457,911...76,457,985 		JBrowse link
G Mir377 microRNA 377 ISO CTD Direct Evidence: marker/mechanism CTD PMID:28545106 NCBI chr 6:134,576,456...134,576,527 JBrowse link
G Mir409 microRNA 409 ISO CTD Direct Evidence: marker/mechanism CTD PMID:28545106 NCBI chr 6:134,579,185...134,579,261
Ensembl chr 6:128,757,779...128,757,858 		JBrowse link
G Mir423 microRNA 423 ISO CTD Direct Evidence: marker/mechanism CTD PMID:24478399 NCBI chr10:62,412,272...62,412,350
Ensembl chr10:61,914,133...61,914,226 		JBrowse link
G Mir487b microRNA 487b ISO CTD Direct Evidence: marker/mechanism CTD PMID:28545106 NCBI chr 6:134,562,890...134,562,971
Ensembl chr 6:128,741,485...128,741,566 		JBrowse link
G Mir532 microRNA 532 ISO CTD Direct Evidence: marker/mechanism CTD PMID:24478399 NCBI chr  X:17,919,185...17,919,263
Ensembl chr  X:15,247,315...15,247,393 		JBrowse link
G Mir628 microRNA 628 ISO CTD Direct Evidence: marker/mechanism CTD PMID:28545106 NCBI chr 8:82,620,496...82,620,579
Ensembl chr 8:73,739,846...73,739,929 		JBrowse link
G Mir92b microRNA 92b ISO CTD Direct Evidence: marker/mechanism CTD PMID:28545106 NCBI chr 2:176,931,653...176,931,735
Ensembl chr 2:174,633,890...174,633,972 		JBrowse link
G Mir98 microRNA 98 ISO CTD Direct Evidence: marker/mechanism CTD PMID:28545106 NCBI chr  X:24,460,648...24,460,755
Ensembl chr  X:20,981,235...20,981,342 		JBrowse link
G Mirlet7d microRNA let-7d ISO CTD Direct Evidence: marker/mechanism CTD PMID:28545106 NCBI chr17:16,322,260...16,322,357
Ensembl chr17:16,115,893...16,115,990 		JBrowse link
G Mki67 marker of proliferation Ki-67 IEP protein:increased expression:hippocampus RGD PMID:20045412 RGD:2317709 NCBI chr 1:199,926,150...199,952,847
Ensembl chr 1:190,496,319...190,522,762 		JBrowse link
G Mlxipl MLX interacting protein-like IEP protein:increased expression:liver (rat) RGD PMID:30029691 RGD:401799626 NCBI chr12:27,178,158...27,213,675
Ensembl chr12:21,543,576...21,577,112 		JBrowse link
G Mmp1 matrix metallopeptidase 1 ISO
IEP		 protein:decreased expression:renal glomerulus (human)
protein:increased expression:nucleus pulposus		 RGD PMID:19506087 PMID:19951028 RGD:2312464, RGD:7207379 NCBI chr 8:12,943,453...12,963,966
Ensembl chr 8:4,658,588...4,679,097 		JBrowse link
G Mmp2 matrix metallopeptidase 2 ISO protein:increased expression:plasma (human) RGD PMID:17320450 RGD:7207195 NCBI chr19:30,327,643...30,355,856
Ensembl chr19:14,154,657...14,182,870 		JBrowse link
G Mmp3 matrix metallopeptidase 3 treatment IEP RGD PMID:23204894 RGD:8694120 NCBI chr 8:12,925,267...12,938,828
Ensembl chr 8:4,640,416...4,653,961 		JBrowse link
G Mmp9 matrix metallopeptidase 9 treatment ISO
IEP		 protein:increased expression:plasma (human) RGD PMID:17320450 PMID:18552985 PMID:23204894 RGD:7207195, RGD:8547849, RGD:8694120 NCBI chr 3:174,103,474...174,111,434
Ensembl chr 3:153,683,858...153,692,120 		JBrowse link
G Mpst mercaptopyruvate sulfurtransferase IEP RGD PMID:20127051 RGD:5134362 NCBI chr 7:111,836,079...111,843,651
Ensembl chr 7:109,955,675...109,963,141 		JBrowse link
G Mras muscle RAS oncogene homolog ISO CTD Direct Evidence: marker/mechanism CTD PMID:28869590 NCBI chr 8:108,823,374...108,886,104
Ensembl chr 8:99,944,036...99,996,408 		JBrowse link
G Mrps12 mitochondrial ribosomal protein S12 ISO ClinVar Annotator: match by term: Type 2 diabetes mellitus ClinVar PMID:28492532 NCBI chr 1:93,153,424...93,156,422
Ensembl chr 1:84,025,899...84,028,780 		JBrowse link
G Mt-co2 mitochondrially encoded cytochrome c oxidase II IEP mRNA:decreased expression:soleus RGD PMID:14563825 RGD:2300410 NCBI chr MT:7,006...7,689
Ensembl chr MT:7,006...7,689 		JBrowse link
G Mt-cyb mitochondrially encoded cytochrome b IEP mRNA:decreased expression:pancreatic islet RGD PMID:7588317 RGD:2298962 NCBI chr MT:14,136...15,278
Ensembl chr MT:14,136...15,278 		JBrowse link
G Mt-nd1 mitochondrially encoded NADH:ubiquinone oxidoreductase core subunit 1 IEP
ISO		 mRNA, protein:decreased expression:soleus, mitochondrion
DNA:polymorphism: :3316G>A, 3394T>C (human)
DNA:SNP: :3394T>C (human)		 RGD PMID:14563825 PMID:15265369 PMID:18679013 RGD:2300410, RGD:2311592, RGD:2311583 NCBI chr MT:2,740...3,694
Ensembl chr MT:2,740...3,694 		JBrowse link
G Mt2 metallothionein 2 ISO associated with Atherosclerosis; DNA:snp:promoter:g.-209A>G (human)
DNA:missense mutation:cds:p.K51R (rs8052394) (human)		 RGD PMID:16518702 PMID:18349110 RGD:6483843, RGD:6483853 NCBI chr19:10,837,934...10,838,708
Ensembl chr19:10,832,002...10,832,784 		JBrowse link
G Mthfr methylenetetrahydrofolate reductase susceptibility
no_association		 ISO DNA:transition:cds:g.677C>T (human)
DNA:transition, transversion:cds:g.677C>T, g.1298A>C (human)		 RGD PMID:21186995 PMID:19996639 PMID:16828193 RGD:6893476, RGD:6893653, RGD:6893657 NCBI chr 5:163,748,346...163,768,141
Ensembl chr 5:158,465,296...158,483,797 		JBrowse link
G Mtnr1a melatonin receptor 1A IEP mRNA:increased expression:pancreas RGD PMID:16441550 RGD:2301037 NCBI chr16:53,876,964...53,896,421
Ensembl chr16:47,144,461...47,163,919 		JBrowse link
G Mtnr1b melatonin receptor 1B susceptibility ISO CTD Direct Evidence: marker/mechanism
ClinVar Annotator: match by term: Diabetes mellitus type 2, susceptibility to | ClinVar Annotator: match by term: MTNR1B-related condition		 CTD
OMIM
ClinVar
RGD		 PMID:19060907 PMID:19060908 PMID:19060909 PMID:22286214 PMID:26551672 More... RGD:9588652 NCBI chr 8:20,919,593...20,934,109
Ensembl chr 8:12,638,219...12,652,737 		JBrowse link
G Mtor mechanistic target of rapamycin kinase susceptibility ISO
IEP		 DNA:SNP: :rs7212142(human)
mRNA,protein:increased expression:hippocampus		 RGD PMID:28536139 PMID:23165862 RGD:13506787, RGD:13506788 NCBI chr 5:164,167,985...164,277,438
Ensembl chr 5:158,884,804...158,994,311 		JBrowse link
G Mtr 5-methyltetrahydrofolate-homocysteine methyltransferase IEP RGD PMID:21818837 RGD:7207079 NCBI chr17:62,911,705...62,996,544
Ensembl chr17:58,220,071...58,304,822 		JBrowse link
G Nampt nicotinamide phosphoribosyltransferase ISO protein:increased expression:serum RGD PMID:18410550 RGD:2311099 NCBI chr 6:55,152,756...55,189,547
Ensembl chr 6:49,424,332...49,462,100 		JBrowse link
G Nccrp1 NCCRP1, F-box associated domain containing ISO ClinVar Annotator: match by term: Type 2 diabetes mellitus ClinVar PMID:28492532 NCBI chr 1:92,962,618...92,966,155
Ensembl chr 1:83,835,083...83,838,676 		JBrowse link
G Ncoa6 nuclear receptor coactivator 6 IEP mRNA:decreased expression:pancreatic islet (rat) RGD PMID:16738321 RGD:9590126 NCBI chr 3:164,351,062...164,422,079
Ensembl chr 3:143,890,896...143,952,268 		JBrowse link
G Neurod1 neuronal differentiation 1 onset
no_association
susceptibility		 ISO DNA:missense mutation: :p.E110K (human
DNA:polymorphism: :p.A45T (human)
DNA:missense mutation: :p.S159P (human)
DNA:missense mutation, nonsense mutation (human)
associated with Obesity;DNA:missense mutation: :p.H241Q (human)
CTD Direct Evidence: marker/mechanism
ClinVar Annotator: match by term: Diabetes mellitus, noninsulin-dependent, late onset | ClinVar Annotator: match by term: NEUROD1-related condition | ClinVar Annotator: match by term: Type 2 diabetes mellitus | ClinVar Annotator: match by term: Type II diabetes mellitus		 CTD
ClinVar
OMIM
RGD		 PMID:10545951 PMID:16123366 PMID:25741868 PMID:28492532 PMID:28664602 More... RGD:2313488, RGD:2313482, RGD:2313480, RGD:2313486, RGD:2313489, RGD:2313478 NCBI chr 3:84,766,483...84,770,454
Ensembl chr 3:64,359,395...64,363,649 		JBrowse link
G Neurog3 neurogenin 3 ISO RGD PMID:17146417 RGD:2313775 NCBI chr20:30,622,533...30,624,015
Ensembl chr20:30,079,780...30,081,262 		JBrowse link
G Nfatc2 nuclear factor of activated T-cells 2 ISO CTD Direct Evidence: marker/mechanism CTD PMID:30718926 NCBI chr 3:177,615,189...177,747,493
Ensembl chr 3:157,198,872...157,328,325 		JBrowse link
G Nfe2l1 NFE2 like bZIP transcription factor 1 ISS OMIM:125853 | OMIM:601283 | OMIM:601407 | OMIM:603694 | OMIM:608036 MouseDO NCBI chr10:82,296,824...82,309,472
Ensembl chr10:81,800,366...81,832,318 		JBrowse link
G Nfe2l2 NFE2 like bZIP transcription factor 2 treatment IEP RGD PMID:23954466 RGD:10412692 NCBI chr 3:81,001,529...81,031,165
Ensembl chr 3:60,594,242...60,621,737 		JBrowse link
G Nfkb1 nuclear factor kappa B subunit 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:17107852 NCBI chr 2:226,689,745...226,805,897
Ensembl chr 2:224,016,214...224,110,404 		JBrowse link
G Nfkbib NFKB inhibitor beta ISO ClinVar Annotator: match by term: Type 2 diabetes mellitus ClinVar PMID:28492532 NCBI chr 1:93,173,817...93,181,387
Ensembl chr 1:84,046,295...84,053,862 		JBrowse link
G Nkx6-1 NK6 homeobox 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:16123366 NCBI chr14:8,274,238...8,281,171
Ensembl chr14:7,969,756...7,976,681 		JBrowse link
G Nog noggin IEP mRNA, protein:increased expression:aorta RGD PMID:21193740 RGD:10430114 NCBI chr10:74,625,874...74,627,501
Ensembl chr10:74,128,712...74,130,339 		JBrowse link
G Nos1 nitric oxide synthase 1 IEP RGD PMID:16323284 RGD:1581689 NCBI chr12:44,276,011...44,456,371
Ensembl chr12:38,626,714...38,710,945 		JBrowse link
G Nos2 nitric oxide synthase 2 susceptibility ISO
IEP		 DNA:insertion/deletion, repeat:promoter (human)
protein:increased expression:retina
protein:increased expression:liver (mouse)
CTD Direct Evidence: marker/mechanism		 CTD
RGD		 PMID:16959961 PMID:19395279 PMID:18773271 PMID:21963495 RGD:2312484, RGD:2313220, RGD:5508747 NCBI chr10:64,313,335...64,349,221
Ensembl chr10:63,815,308...63,851,210 		JBrowse link
G Nos3 nitric oxide synthase 3 IEP
ISO		 CTD Direct Evidence: marker/mechanism CTD
RGD		 PMID:12716763 PMID:16959961 PMID:18356581 RGD:2292097 NCBI chr 4:11,686,088...11,706,604
Ensembl chr 4:10,793,834...10,814,166 		JBrowse link
G Notch2 notch receptor 2 ISO CTD Direct Evidence: marker/mechanism CTD PMID:18372903 NCBI chr 2:188,299,336...188,432,823
Ensembl chr 2:185,610,589...185,744,088 		JBrowse link
G Nppa natriuretic peptide A ISO RGD PMID:19675071 RGD:2313586 NCBI chr 5:163,712,184...163,713,493
Ensembl chr 5:158,429,042...158,430,351 		JBrowse link
G Nppb natriuretic peptide B IEP
ISO		 protein:increased expression:plasma
protein:increased expression:serum		 RGD PMID:18192848 PMID:22037102 RGD:2293330, RGD:5685645 NCBI chr 5:163,699,955...163,701,314
Ensembl chr 5:158,416,866...158,418,168 		JBrowse link
G Npy neuropeptide Y ISO DNA:missense mutation:cds:p.L7P (human) RGD PMID:15926114 RGD:1580183 NCBI chr 4:80,212,111...80,219,310
Ensembl chr 4:78,881,264...78,888,495 		JBrowse link
G Nr0b2 nuclear receptor subfamily 0, group B, member 2 ISO DNA:polymorphisms: :multiple RGD PMID:18781616 RGD:2311604 NCBI chr 5:151,063,160...151,066,475
Ensembl chr 5:145,779,294...145,782,609 		JBrowse link
G Nr1d1 nuclear receptor subfamily 1, group D, member 1 treatment IEP RGD PMID:23637135 RGD:10448992 NCBI chr10:84,224,599...84,231,812
Ensembl chr10:83,728,318...83,735,705 		JBrowse link
G Nr1h2 nuclear receptor subfamily 1, group H, member 2 ISO RGD PMID:20939869 RGD:13506790 NCBI chr 1:104,178,483...104,183,863
Ensembl chr 1:95,041,967...95,047,377 		JBrowse link
G Nr1h3 nuclear receptor subfamily 1, group H, member 3 ISO mRNA:increased expression:peripheral blood mononuclear cell (human) RGD PMID:28871240 RGD:401850555 NCBI chr 3:97,614,616...97,632,053
Ensembl chr 3:77,158,808...77,168,722 		JBrowse link
G Nr3c1 nuclear receptor subfamily 3, group C, member 1 IDA RGD PMID:17292727 RGD:4892117 NCBI chr18:31,522,783...31,644,508
Ensembl chr18:31,271,681...31,393,375 		JBrowse link
G Nucb2 nucleobindin 2 ISO
IEP		 mRNA:decreased expression:islet of Langerhans:
protein:decreased expression:pancreas:		 RGD PMID:22108805 PMID:20032201 RGD:9831161, RGD:9831177 NCBI chr 1:180,185,121...180,221,644
Ensembl chr 1:170,750,877...170,787,353 		JBrowse link
G Nus1 NUS1 dehydrodolichyl diphosphate synthase subunit ISO CTD Direct Evidence: marker/mechanism CTD PMID:30718926 PMID:33812996 NCBI chr20:32,354,519...32,381,265
Ensembl chr20:31,811,817...31,838,561 		JBrowse link
G Ogg1 8-oxoguanine DNA glycosylase ISO protein:increased expression:pancreatic islet, mitochondrion
CTD Direct Evidence: marker/mechanism		 CTD
RGD		 PMID:22652274 PMID:12003641 RGD:2317133 NCBI chr 4:148,030,237...148,037,599
Ensembl chr 4:146,474,750...146,484,766 		JBrowse link
G Oxct1 3-oxoacid CoA transferase 1 IEP mRNA, protein:decreased expression, decreased activity:pancreatic islets (rat) RGD PMID:20460097 RGD:2326185 NCBI chr 2:54,963,964...55,112,303
Ensembl chr 2:53,236,368...53,384,714 		JBrowse link
G P2ry12 purinergic receptor P2Y12 ISO RGD PMID:15483100 RGD:6480536 NCBI chr 2:145,631,487...145,673,194
Ensembl chr 2:143,481,430...143,523,361 		JBrowse link
G Paf1 PAF1 homolog, Paf1/RNA polymerase II complex component ISO ClinVar Annotator: match by term: Type 2 diabetes mellitus ClinVar PMID:28492532 NCBI chr 1:92,811,197...92,816,775
Ensembl chr 1:83,668,813...83,689,237 		JBrowse link
G Pak4 p21 (RAC1) activated kinase 4 ISO ClinVar Annotator: match by term: Type 2 diabetes mellitus ClinVar PMID:28492532 NCBI chr 1:92,977,437...93,016,721
Ensembl chr 1:83,849,904...83,859,413 		JBrowse link
G Pam peptidylglycine alpha-amidating monooxygenase ISO CTD Direct Evidence: marker/mechanism CTD PMID:24464100 PMID:30054598 NCBI chr 9:105,445,812...105,719,287
Ensembl chr 9:98,122,916...98,271,965 		JBrowse link
G Pappa pappalysin ISO protein:decreased expression:serum RGD PMID:17728480 RGD:2313776 NCBI chr 5:83,513,358...83,751,364
Ensembl chr 5:78,498,300...78,730,666 		JBrowse link
G Parl presenilin associated, rhomboid-like onset ISO DNA:missense mutation:cds:p.L262V (human)
mRNA:decreased expression:vastus lateralis (human)		 RGD PMID:19185381 PMID:20444421 RGD:12880445, RGD:12902628 NCBI chr11:94,097,559...94,124,915
Ensembl chr11:80,593,192...80,620,506 		JBrowse link
G Parp1 poly (ADP-ribose) polymerase 1 ISO RGD PMID:15895395 RGD:11075068 NCBI chr13:94,839,484...94,871,295
Ensembl chr13:92,307,586...92,339,404 		JBrowse link
G Pax4 paired box 4 onset ISO
IMP		 DNA:polymorphism, mutations: :p.R192H, p.R164W, IVS7-1G>A (human)
DNA:mutation: :p.R121W (human)
CTD Direct Evidence: marker/mechanism
ClinVar Annotator: match by term: Diabetes mellitus, noninsulin-dependent, late onset | ClinVar Annotator: match by term: Type 2 diabetes mellitus | ClinVar Annotator: match by term: Type II diabetes mellitus		 CTD
ClinVar
OMIM
RGD		 PMID:9536098 PMID:11723072 PMID:15596543 PMID:16423628 PMID:17576681 More... RGD:2311632, RGD:2311635 NCBI chr 4:58,023,873...58,032,265
Ensembl chr 4:57,058,462...57,063,408 		JBrowse link
G Pax6 paired box 6 ISO CTD Direct Evidence: marker/mechanism CTD PMID:16123366 NCBI chr 3:112,590,034...112,611,771
Ensembl chr 3:92,135,637...92,157,014 		JBrowse link
G Pc pyruvate carboxylase ISO CTD Direct Evidence: marker/mechanism CTD PMID:16123366 NCBI chr 1:211,228,708...211,327,792
Ensembl chr 1:201,804,267...201,898,380 		JBrowse link
G Pck1 phosphoenolpyruvate carboxykinase 1 no_association ISO
IDA		 DNA:SNPs (human) RGD PMID:18443203 PMID:17242918 PMID:19070910 PMID:16978381 PMID:16620271 RGD:2311640, RGD:2311643, RGD:2311639, RGD:1601239, RGD:1601241 NCBI chr 3:182,348,572...182,354,521
Ensembl chr 3:161,930,256...161,936,191 		JBrowse link
G Pcsk1 proprotein convertase subtilisin/kexin type 1 no_association IDA
IEP
ISO		 protein:altered expression:pancreatic islet (rat)
DNA:missense mutations:cds:p.R53Q, p.Q638E (human)
protein:decreased expression:pancreatic islet (mouse)
protein:increased expression:pancreatic alpha cell (mouse)		 RGD PMID:17630003 PMID:12475375 PMID:8666140 PMID:18448419 PMID:18941442 RGD:2308898, RGD:2298715, RGD:2308935, RGD:2308932, RGD:2308930 NCBI chr 2:6,130,045...6,176,974
Ensembl chr 2:4,395,543...4,442,434 		JBrowse link
G Pcsk2 proprotein convertase subtilisin/kexin type 2 ISO DNA:repeats:intron:IVS2CA (human)
CTD Direct Evidence: marker/mechanism		 CTD
RGD		 PMID:16123366 PMID:7698505 RGD:2308936 NCBI chr 3:151,333,938...151,636,628
Ensembl chr 3:130,880,422...131,183,127 		JBrowse link
G Pdcd1 programmed cell death 1 ISO protein:increased expression:kidney RGD PMID:23219834 RGD:7248672 NCBI chr 9:101,866,124...101,879,278
Ensembl chr 9:94,418,791...94,431,937 		JBrowse link
G Pdx1 pancreatic and duodenal homeobox 1 no_association ISO
IEP		 protein:decreased expression:pancreas (rat)
protein:increased expression:pancreatic duct (mouse)
DNA:insertion, polymorphism:cds:InsCCG243, Q59L, D76N (human)
mRNA:increased expression:pancreatic islet (human)
DNA:polymorphism:cds:D76N (human)
DNA:deletion:exon 2 (mouse)
CTD Direct Evidence: marker/mechanism
ClinVar Annotator: match by term: Diabetes Mellitus, Noninsulin-Dependent, with Acanthosis Nigricans and Hypertension | ClinVar Annotator: match by term: Diabetes mellitus type 2, susceptibility to | ClinVar Annotator: match by term: Type 2 diabetes mellitus | ClinVar Annotator: match by term: Type II diabetes mellitus		 CTD
RGD
ClinVar
OMIM		 PMID:10545530 PMID:10545531 PMID:10720084 PMID:11022198 PMID:11270685 More... RGD:2311308, RGD:2311305, RGD:2311219, RGD:2311221, RGD:2311307, RGD:2311306, RGD:2311308, RGD:2311217 NCBI chr12:12,793,957...12,799,156
Ensembl chr12:7,757,865...7,763,064 		JBrowse link
G Pecam1 platelet and endothelial cell adhesion molecule 1 ISO protein:increased expression:bone marrow stem cell (mouse) RGD PMID:21984919 RGD:6771358 NCBI chr10:92,090,263...92,152,002
Ensembl chr10:91,590,521...91,652,116 		JBrowse link
G Pepd peptidase D ISO CTD Direct Evidence: marker/mechanism CTD PMID:22158537 NCBI chr 1:96,673,624...96,818,197
Ensembl chr 1:87,536,609...87,681,231 		JBrowse link
G Phox2a paired-like homeobox 2a ISS OMIM:125853 | OMIM:601283 | OMIM:601407 | OMIM:603694 | OMIM:608036 MouseDO NCBI chr 1:165,590,757...165,595,122
Ensembl chr 1:156,178,754...156,183,118 		JBrowse link
G Pik3c2a phosphatidylinositol-4-phosphate 3-kinase, catalytic subunit type 2 alpha ISO mRNA:decreased expression:Islets of Langerhans RGD PMID:21127054 RGD:7243008 NCBI chr 1:180,012,248...180,117,786
Ensembl chr 1:170,577,942...170,683,472 		JBrowse link
G Pik3c2g phosphatidylinositol-4-phosphate 3-kinase, catalytic subunit type 2 gamma susceptibility ISO DNA:SNP:cds:437C>T(human) RGD PMID:17991425 RGD:13506796 NCBI chr 4:174,215,527...174,583,378
Ensembl chr 4:172,484,345...172,850,544 		JBrowse link
G Pik3cb phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit beta treatment ISO RGD PMID:11812753 RGD:13506799 NCBI chr 8:108,474,017...108,579,140
Ensembl chr 8:99,594,644...99,699,663 		JBrowse link
G Pik3cg phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit gamma ISO CTD Direct Evidence: marker/mechanism CTD PMID:31626838 NCBI chr 6:54,494,247...54,529,563
Ensembl chr 6:48,766,864...48,802,043 		JBrowse link
G Pik3r1 phosphoinositide-3-kinase regulatory subunit 1 susceptibility IEP
ISO		 protein:increased phosphorylation:retina (rat)
DNA:polymorphism: :		 RGD PMID:18443201 PMID:14551916 RGD:4108490, RGD:11067972 NCBI chr 2:34,612,946...34,697,660
Ensembl chr 2:32,882,032...32,963,631 		JBrowse link
G Pklr pyruvate kinase L/R susceptibility
no_association		 ISO DNA:SNPs:introns,exons:
DNA:SNP: :rs3020781(human)		 RGD PMID:12196482 PMID:19111066 RGD:13506801, RGD:13506802 NCBI chr 2:176,840,779...176,849,637
Ensembl chr 2:174,543,039...174,551,870 		JBrowse link
G Pla2g7 phospholipase A2 group VII ISO RGD PMID:22399516 RGD:6482782 NCBI chr 9:24,859,491...24,901,747
Ensembl chr 9:17,362,225...17,404,476 		JBrowse link
G Plat plasminogen activator, tissue type ISO
IEP		 associated with Obesity
mRNA:decreased expression:kidney
protein:decreased expression:plasma (rat)		 RGD PMID:16724515 PMID:15901895 PMID:14693179 PMID:16038272 PMID:18235054 More... RGD:2311670, RGD:2311673, RGD:2311675, RGD:2311672, RGD:2311665, RGD:1598920 NCBI chr16:75,943,061...76,022,037
Ensembl chr16:69,240,585...69,268,223 		JBrowse link
G Plaur plasminogen activator, urokinase receptor onset ISO protein:increased expression:plasma RGD PMID:22050462 RGD:6483792 NCBI chr 1:89,181,363...89,196,308
Ensembl chr 1:80,050,324...80,068,595 		JBrowse link
G Pld3 phospholipase D family, member 3 ISO ClinVar Annotator: match by term: Type 2 diabetes mellitus ClinVar PMID:28492532 NCBI chr 1:91,949,465...91,971,834
Ensembl chr 1:82,821,875...82,844,072 		JBrowse link
G Plekha1 pleckstrin homology domain containing A1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:28869590 NCBI chr 1:194,858,239...194,909,418
Ensembl chr 1:185,428,048...185,479,156 		JBrowse link
G Plekhg2 pleckstrin homology and RhoGEF domain containing G2 ISO ClinVar Annotator: match by term: Type 2 diabetes mellitus ClinVar PMID:28492532 NCBI chr 1:92,779,449...92,792,610
Ensembl chr 1:83,647,748...83,665,063 		JBrowse link
G Pln phospholamban IEP mRNA:decreased expression:heart left ventricle RGD PMID:22621761 RGD:7327183 NCBI chr20:33,166,512...33,182,241 JBrowse link
G Pnpla3 patatin-like phospholipase domain containing 3 ISO DNA:SNP: :rs738409 (p.I148M) (human) RGD PMID:31377187 RGD:14981594 NCBI chr 7:117,173,485...117,194,065
Ensembl chr 7:115,293,538...115,314,077 		JBrowse link
G Pomc proopiomelanocortin IEP associated with alcohol use disorder RGD PMID:33057655 RGD:407431647 NCBI chr 6:32,659,137...32,665,175
Ensembl chr 6:26,939,837...26,945,664 		JBrowse link
G Pon1 paraoxonase 1 severity
no_association		 ISO protein:decreased expression:serum
protein:increased expression:serum
DNA:polymorphism: :p.Q192R (human)
associated with Diabetic Retinopathy;DNA:missense mutations:cds:p.L55M, p.Q192R (human)		 RGD PMID:17949258 PMID:19328014 PMID:18290860 PMID:10677395 PMID:9591753 RGD:2313270, RGD:2307252, RGD:2313269, RGD:8547560, RGD:8547663 NCBI chr 4:34,261,312...34,292,327
Ensembl chr 4:33,294,722...33,321,360 		JBrowse link
G Pon2 paraoxonase 2 ISO DNA:missense mutation:cds:p.S311C (human)
associated with Diabetic Retinopathy;DNA:missense mutation:cds:p.C310S (human)		 RGD PMID:18776646 PMID:10677395 RGD:2313490, RGD:8547560 NCBI chr 4:34,356,270...34,391,684
Ensembl chr 4:33,389,714...33,425,248 		JBrowse link
G Ppara peroxisome proliferator activated receptor alpha ISO CTD Direct Evidence: marker/mechanism CTD PMID:17317762 PMID:31626838 NCBI chr 7:118,712,261...118,780,723
Ensembl chr 7:116,832,756...116,895,346 		JBrowse link
G Ppard peroxisome proliferator-activated receptor delta ISO
ISS		 DNA:SNPs
OMIM:125853 | OMIM:601283 | OMIM:601407 | OMIM:603694 | OMIM:608036		 MouseDO
RGD		 PMID:16804087 RGD:1625186 NCBI chr20:6,300,527...6,365,707
Ensembl chr20:6,298,785...6,363,968 		JBrowse link
G Pparg peroxisome proliferator-activated receptor gamma susceptibility
no_association		 ISO DNA:polymorphism: :p.P12A (human)
DNA:snp:cds:p.P12A (human)
CTD Direct Evidence: marker/mechanism|therapeutic
ClinVar Annotator: match by term: Diabetes Mellitus, Noninsulin-Dependent, with Acanthosis Nigricans and Hypertension | ClinVar Annotator: match by term: Type 2 diabetes mellitus
ClinVar Annotator: match by term: Diabetes mellitus, noninsulin-dependent, late onset | ClinVar Annotator: match by term: Type 2 diabetes mellitus		 OMIM
CTD
ClinVar
RGD		 PMID:9467001 PMID:9792554 PMID:10381354 PMID:10523018 PMID:10622252 More... RGD:2301861, RGD:2301846, RGD:2301851, RGD:8552822 NCBI chr 4:150,095,743...150,221,104
Ensembl chr 4:148,423,194...148,548,468 		JBrowse link
G Ppargc1a PPARG coactivator 1 alpha treatment
susceptibility
no_association		 ISO
IDA
IEP		 DNA:polymorphism:exon:p.G482S (human)
DNA:hypermethylation:promoter:g.-383 (human)
protein:decreased expression:vastus lateralis (human)
DNA:snps:intron:IVS3+52T>G, IVS3+21963A>G (rs2946385, rs4235308) (human)
DNA:polymorphism:exon:p.G482S (human, Pima Indians)
protein:decreased expression:dorsal root ganglia
mRNA:decreased expression:soleus muscle:type I muscle fiber (rat)
CTD Direct Evidence: marker/mechanism		 CTD
RGD		 PMID:15592662 PMID:17317762 PMID:18270681 PMID:23251491 PMID:23250358 More... RGD:2311391, RGD:7241849, RGD:7241851, RGD:7242009, RGD:7242032, RGD:7242043, RGD:7242067, RGD:7242175, RGD:10059689 NCBI chr14:63,073,505...63,729,215
Ensembl chr14:58,861,144...59,512,656 		JBrowse link
G Ppargc1b PPARG coactivator 1 beta no_association ISO DNA:polymorphism:exon:102605C>A RGD PMID:16759305 RGD:1642500 NCBI chr18:57,029,264...57,131,466
Ensembl chr18:54,758,902...54,861,194 		JBrowse link
G Ppp1r3a protein phosphatase 1, regulatory subunit 3A no_association
onset		 ISO
ISS		 DNA:missense mutation:cds:p.D905Y (human)
DNA:missense mutation: :p.D905Y (human)
DNA:missense mutation::p.D905Y (human)
DNA:missense mutations, polymorphisms:CDS, 3' UTR:p.R883S, p.D905Y (human)
DNA:insertion/deletion
ClinVar Annotator: match by term: INSULIN RESISTANCE, SEVERE, DIGENIC | ClinVar Annotator: match by term: PPP1R3A-related condition | ClinVar Annotator: match by term: Type 2 diabetes mellitus
CTD Direct Evidence: marker/mechanism
OMIM:125853 | OMIM:601283 | OMIM:601407 | OMIM:603694 | OMIM:608036		 OMIM
ClinVar
CTD
MouseDO
RGD		 PMID:7581368 PMID:12118251 PMID:25741868 PMID:11793847 PMID:10868947 More... RGD:2311560, RGD:2311552, RGD:2311532, RGD:2311531, RGD:2311515, RGD:2311596 NCBI chr 4:43,905,648...43,946,236
Ensembl chr 4:42,939,599...42,980,638 		JBrowse link
G Ppp1r3c protein phosphatase 1, regulatory subunit 3C ISS OMIM:125853 | OMIM:601283 | OMIM:601407 | OMIM:603694 | OMIM:608036 MouseDO NCBI chr 1:243,873,524...243,878,527
Ensembl chr 1:234,460,652...234,465,961 		JBrowse link
G Ppp2ca protein phosphatase 2 catalytic subunit alpha IEP mRNA:increased expression:liver, quadriceps, epididymal fat pad (rat) RGD PMID:22087313 RGD:8693665 NCBI chr10:36,856,534...36,878,789
Ensembl chr10:36,358,101...36,377,862 		JBrowse link
G Prkaa1 protein kinase AMP-activated catalytic subunit alpha 1 IMP RGD PMID:20054491 RGD:2316808 NCBI chr 2:55,967,766...56,003,450
Ensembl chr 2:54,240,137...54,275,978 		JBrowse link
G Prkaa2 protein kinase AMP-activated catalytic subunit alpha 2 susceptibility ISO DNA:SNPs RGD PMID:16567511 RGD:1625266 NCBI chr 5:125,036,945...125,109,010
Ensembl chr 5:119,813,226...119,879,543 		JBrowse link
G Prkcb protein kinase C, beta ISO CTD Direct Evidence: marker/mechanism CTD PMID:15531508 NCBI chr 1:186,263,397...186,594,743
Ensembl chr 1:176,832,226...177,163,536 		JBrowse link
G Prkce protein kinase C, epsilon IEP mRNA,protein:decreased expression:liver: RGD PMID:26398746 RGD:13506804 NCBI chr 6:13,718,050...14,204,931
Ensembl chr 6:7,965,048...8,451,719 		JBrowse link
G Prkci protein kinase C, iota ISS OMIM:125853 | OMIM:601283 | OMIM:601407 | OMIM:603694 | OMIM:608036 MouseDO NCBI chr 2:114,250,398...114,310,784
Ensembl chr 2:112,321,929...112,382,352 		JBrowse link
G Prkcz protein kinase C, zeta IEP mRNA,protein:decreased expression:liver,pancreas: RGD PMID:26398746 RGD:13506804 NCBI chr 5:171,101,774...171,212,694
Ensembl chr 5:165,819,466...165,930,367 		JBrowse link
G Prkn parkin RBR E3 ubiquitin protein ligase IEP protein:decreased expression:cerebral cortex (rat) RGD PMID:28573460 RGD:13432564 NCBI chr 1:51,236,410...52,430,242
Ensembl chr 1:48,690,556...49,882,555 		JBrowse link
G Prox1 prospero homeobox 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:20081858 NCBI chr13:104,196,615...104,251,007
Ensembl chr13:101,669,184...101,711,183 		JBrowse link
G Prx periaxin ISO ClinVar Annotator: match by term: Type 2 diabetes mellitus ClinVar PMID:28492532 NCBI chr 1:91,912,669...91,934,754
Ensembl chr 1:82,786,815...82,807,407 		JBrowse link
G Psmc4 proteasome 26S subunit, ATPase 4 ISO ClinVar Annotator: match by term: Type 2 diabetes mellitus ClinVar PMID:28492532 NCBI chr 1:92,476,690...92,485,268
Ensembl chr 1:83,348,592...83,357,494 		JBrowse link
G Psmd6 proteasome 26S subunit, non-ATPase 6 ISO CTD Direct Evidence: marker/mechanism CTD PMID:22158537 NCBI chr15:13,532,675...13,542,682
Ensembl chr15:11,102,180...11,205,620 		JBrowse link
G Ptf1a pancreas associated transcription factor 1a ISO ClinVar Annotator: match by term: Type 2 diabetes mellitus ClinVar NCBI chr17:86,959,621...86,961,475
Ensembl chr17:82,051,281...82,053,135 		JBrowse link
G Ptgds prostaglandin D2 synthase IEP protein:increased expression:urine RGD PMID:16384826 RGD:1642580 NCBI chr 3:28,680,044...28,682,978
Ensembl chr 3:8,281,899...8,284,833 		JBrowse link
G Ptgis prostaglandin I2 synthase ISO protein:decreased expression:hypodermis (human) RGD PMID:24225501 RGD:401901153 NCBI chr 3:176,347,589...176,383,251
Ensembl chr 3:155,916,412...155,965,451 		JBrowse link
G Ptgs2 prostaglandin-endoperoxide synthase 2 IEP RGD PMID:18706904 RGD:2300222 NCBI chr13:64,714,063...64,722,320
Ensembl chr13:62,163,932...62,172,188 		JBrowse link
G Pth parathyroid hormone ISO DNA:snp:exon:g.350C>A rs6256 (human) RGD PMID:22777106 RGD:7242744 NCBI chr 1:176,942,901...176,946,034
Ensembl chr 1:167,508,598...167,511,530 		JBrowse link
G Ptpn1 protein tyrosine phosphatase, non-receptor type 1 susceptibility
no_association		 ISO CTD Direct Evidence: marker/mechanism
DNA:missense mutation:CDS:p.P387L (human)
ClinVar Annotator: match by term: PTPN1-related condition		 OMIM
CTD
ClinVar
RGD		 PMID:25741868 PMID:28492532 PMID:15715684 PMID:11756316 RGD:401965404, RGD:401965405 NCBI chr 3:177,056,588...177,106,424
Ensembl chr 3:156,638,769...156,687,504 		JBrowse link
G Ptprd protein tyrosine phosphatase, receptor type, D susceptibility ISO associated with Environmental Illness; DNA:SNP:intron: (rs16927668) (Human) RGD PMID:27281273 RGD:401850598 NCBI chr 5:95,093,221...97,415,498
Ensembl chr 5:90,048,966...92,369,396 		JBrowse link
G Rarres2 retinoic acid receptor responder 2 IEP protein:increased expression:multiple: RGD PMID:30873215 RGD:15036825 NCBI chr 4:78,853,450...78,856,652
Ensembl chr 4:77,522,535...77,525,556 		JBrowse link
G Rbfox2 RNA binding fox-1 homolog 2 ISO mRNA:splice variant: heart (human) RGD PMID:27239029 RGD:329845874 NCBI chr 7:110,691,230...110,934,901
Ensembl chr 7:108,810,628...109,054,691 		JBrowse link
G Rbp4 retinol binding protein 4 susceptibility
disease_progression
severity		 IEP
ISO		 protein:increased expression:serum
DNA:polymorphism
protein:increased expression:blood plasma (human)
mRNA:increased expression:epicardial fat (human)
protein:increased expression:blood serum (human)
associated with arteriosclerosis and chronic kidney disease;protein:increased expression:blood plasma (human)
DNA:SNP:promoter:-803G>A (human)		 RGD PMID:19080170 PMID:19506831 PMID:17174134 PMID:24647386 PMID:21645024 More... RGD:2311652, RGD:2311651, RGD:1601615, RGD:329845577, RGD:329845584, RGD:329845844, RGD:329845851, RGD:329845855, RGD:329845878, RGD:329849119 NCBI chr 1:245,306,349...245,313,551
Ensembl chr 1:235,893,917...235,901,399 		JBrowse link
G Rbpj recombination signal binding protein for immunoglobulin kappa J region ISO ClinVar Annotator: match by term: Diabetes mellitus type 2, susceptibility to | ClinVar Annotator: match by term: Type 2 diabetes mellitus ClinVar PMID:25741868 PMID:29924900 NCBI chr14:61,551,366...61,736,220
Ensembl chr14:57,338,507...57,523,353 		JBrowse link
G Rbpjl recombination signal binding protein for immunoglobulin kappa J region-like ISO ClinVar Annotator: match by term: Type 2 diabetes mellitus ClinVar PMID:25741868 NCBI chr 3:173,553,389...173,565,869
Ensembl chr 3:153,134,140...153,146,513 		JBrowse link
G Reg3b regenerating family member 3 beta IEP mRNA:increased expression:islet of Langerhans (rat) RGD PMID:24587207 RGD:9831427 NCBI chr 4:112,419,776...112,423,014
Ensembl chr 4:110,861,775...110,865,015 		JBrowse link
G Retn resistin no_association
susceptibility		 ISO DNA:polymorphism: :299G>A (human)
DNA:SNP:3' utr:*62A>G (human)
DNA:SNP:promoter:-420G>C (rs1862513) (human)
protein:increased expression:serum
DNA:SNPs:promoter:-394C>G, -420G>C (rs1862513) (human)
protein:decreased expression:serum
ClinVar Annotator: match by term: HYPERTENSION, INSULIN RESISTANCE-RELATED, SUSCEPTIBILITY TO
CTD Direct Evidence: marker/mechanism		 ClinVar
OMIM
CTD
RGD		 PMID:11558907 PMID:12629116 PMID:19177195 PMID:12629116 PMID:19738363 More... RGD:2313498, RGD:1624968, RGD:2313494, RGD:2313497, RGD:2313495, RGD:7207163 NCBI chr12:6,508,653...6,511,115
Ensembl chr12:1,710,881...1,712,620 		JBrowse link
G Rinl Ras and Rab interactor-like ISO ClinVar Annotator: match by term: Type 2 diabetes mellitus ClinVar PMID:28492532 NCBI chr 1:93,204,543...93,215,851
Ensembl chr 1:84,077,265...84,088,330 		JBrowse link
G Rnf6 ring finger protein 6 ISO CTD Direct Evidence: marker/mechanism CTD PMID:28869590 NCBI chr12:13,929,160...13,940,663
Ensembl chr12:8,816,833...8,826,847 		JBrowse link
G Rps16 ribosomal protein S16 ISO ClinVar Annotator: match by term: Type 2 diabetes mellitus ClinVar PMID:28492532 NCBI chr 1:92,770,658...92,773,603
Ensembl chr 1:83,643,130...83,646,206
Ensembl chr19:83,643,130...83,646,206 		JBrowse link
G Rrad RRAD, Ras related glycolysis inhibitor and calcium channel regulator ISO associated with Obesity;DNA:polymorphism:intron:4681C>T (human)
DNA:repeat:intron (human)		 RGD PMID:15161552 PMID:10024077 RGD:2311704, RGD:2311705 NCBI chr19:360,581...363,874
Ensembl chr19:354,198...357,417 		JBrowse link
G RT1-Ba RT1 class II, locus Ba susceptibility ISO RGD PMID:16331578 RGD:2301814 NCBI chr20:4,577,057...4,581,650
Ensembl chr20:4,575,134...4,579,744 		JBrowse link
G S100a6 S100 calcium binding protein A6 ISO CTD Direct Evidence: marker/mechanism CTD PMID:16123366 NCBI chr 2:178,398,189...178,399,763
Ensembl chr 2:176,100,899...176,102,180 		JBrowse link
G Samd4b sterile alpha motif domain containing 4B ISO ClinVar Annotator: match by term: Type 2 diabetes mellitus ClinVar PMID:28492532 NCBI chr 1:92,816,955...92,855,243
Ensembl chr 1:83,689,413...83,713,853 		JBrowse link
G Sars2 seryl-tRNA synthetase 2, mitochondrial ISO ClinVar Annotator: match by term: Type 2 diabetes mellitus ClinVar PMID:28492532 NCBI chr 1:93,156,514...93,171,943
Ensembl chr 1:84,028,986...84,040,725 		JBrowse link
G Scn1b sodium voltage-gated channel beta subunit 1 IEP mRNA:increased expression:heart ventricle RGD PMID:22581745 RGD:6484255 NCBI chr 1:95,481,298...95,491,211
Ensembl chr 1:86,353,917...86,363,739 		JBrowse link
G Sctr secretin receptor ISO CTD Direct Evidence: marker/mechanism CTD PMID:30718926 NCBI chr13:33,680,562...33,744,049
Ensembl chr13:31,127,858...31,180,189 		JBrowse link
G Sdc2 syndecan 2 ISO protein:increased expression:kidney RGD PMID:14976204 RGD:2311706 NCBI chr 7:66,012,405...66,125,101
Ensembl chr 7:64,127,110...64,241,081 		JBrowse link
G Sdc4 syndecan 4 ISO mRNA:increased expression:kidney
ClinVar Annotator: match by term: Type 2 diabetes mellitus		 ClinVar
RGD		 PMID:14633120 RGD:2311707 NCBI chr 3:173,574,239...173,592,923
Ensembl chr 3:153,154,896...153,173,580 		JBrowse link
G Sdf2l1 stromal cell-derived factor 2-like 1 susceptibility IAGP DNA:deletion:exons, introns:g.3_910del (rat) RGD PMID:27463508 RGD:11528530 NCBI chr11:97,376,878...97,379,120
Ensembl chr11:83,872,659...83,874,902 		JBrowse link
G Sdhb succinate dehydrogenase complex iron sulfur subunit B ISS OMIM:125853 | OMIM:601283 | OMIM:601407 | OMIM:603694 | OMIM:608036 MouseDO NCBI chr 5:158,547,775...158,568,589
Ensembl chr 5:153,264,899...153,314,293 		JBrowse link
G Selenov selenoprotein V ISO ClinVar Annotator: match by term: Type 2 diabetes mellitus ClinVar PMID:28492532 NCBI chr 1:92,679,034...92,686,320
Ensembl chr 1:83,551,473...83,558,756 		JBrowse link
G Sell selectin L no_association ISO RGD PMID:22119815 RGD:7175303 NCBI chr13:78,950,100...78,969,604
Ensembl chr13:76,416,915...76,436,456 		JBrowse link
G Selp selectin P ISO protein:increased expression:plasma RGD PMID:17598012 RGD:2312303 NCBI chr13:79,009,379...79,044,994
Ensembl chr13:76,476,295...76,511,845 		JBrowse link
G Serpina12 serpin family A member 12 treatment IDA RGD PMID:16030142 RGD:1547845 NCBI chr 6:128,717,334...128,732,049
Ensembl chr 6:122,952,552...122,967,271 		JBrowse link
G Serpinc1 serpin family C member 1 ISO protein:increased activity:plasma (human) RGD PMID:7974333 RGD:2312416 NCBI chr13:75,790,558...75,804,826
Ensembl chr13:73,257,179...73,284,293 		JBrowse link
G Serpine1 serpin family E member 1 no_association
treatment		 ISO
IEP
IDA		 DNA:polymorphism:
mRNA:increased expression:kidney
protein:decreased expression:plasma (human)		 RGD PMID:16855181 PMID:19706694 PMID:8236167 PMID:14614217 RGD:1624959, RGD:2316116, RGD:8547723, RGD:2312394 NCBI chr12:25,237,977...25,248,356
Ensembl chr12:19,601,272...19,611,657 		JBrowse link
G Serpinf1 serpin family F member 1 treatment
severity		 ISO
IEP
IMP		 protein:increased expression:serum
protein:increased expression:plasma (rat)
human protein in a rat model		 RGD PMID:18715664 PMID:17653050 PMID:24530621 PMID:24530621 RGD:2312340, RGD:8554888, RGD:8655541, RGD:8655541 NCBI chr10:60,748,504...60,760,898
Ensembl chr10:60,249,708...60,262,646 		JBrowse link
G Sfrp4 secreted frizzled-related protein 4 ISO CTD Direct Evidence: marker/mechanism CTD PMID:23140642 NCBI chr17:49,974,532...50,026,448
Ensembl chr17:45,234,097...45,330,736 		JBrowse link
G Sgcg sarcoglycan, gamma susceptibility ISO DNA:SNP: : rs9552911(human) RGD PMID:28123479 RGD:13605620 NCBI chr15:39,564,920...39,611,149
Ensembl chr15:35,386,534...35,435,148 		JBrowse link
G Shbg sex hormone binding globulin susceptibility ISO DNA, protein:SNPs, decreased expression:rs6257, rs6259, plasma (human)
CTD Direct Evidence: marker/mechanism		 CTD
RGD		 PMID:21982312 PMID:19657112 RGD:2313782 NCBI chr10:54,831,716...54,849,162
Ensembl chr10:54,332,941...54,351,057 		JBrowse link
G Sirt1 sirtuin 1 treatment ISO
IMP		 associated with Obesity
CTD Direct Evidence: marker/mechanism		 CTD
RGD		 PMID:23834033 PMID:18046409 PMID:19549853 RGD:9585769, RGD:9585997 NCBI chr20:25,305,953...25,328,000
Ensembl chr20:25,306,917...25,329,260 		JBrowse link
G Sirt2 sirtuin 2 ISO ClinVar Annotator: match by term: Type 2 diabetes mellitus ClinVar PMID:28492532 NCBI chr 1:93,181,472...93,204,499
Ensembl chr 1:84,052,903...84,076,975 		JBrowse link
G Sirt3 sirtuin 3 ISO mRNA:decreased expression:pancreatic islet RGD PMID:23397292 RGD:9586042 NCBI chr 1:205,371,703...205,394,145
Ensembl chr 1:195,942,073...195,964,808 		JBrowse link
G Slc1a2 solute carrier family 1 member 2 ISO CTD Direct Evidence: marker/mechanism CTD PMID:30718926 NCBI chr 3:109,460,109...109,590,445
Ensembl chr 3:89,005,129...89,126,498 		JBrowse link
G Slc22a3 solute carrier family 22 member 3 ISO CTD Direct Evidence: marker/mechanism CTD PMID:28869590 NCBI chr 1:50,783,218...50,872,358
Ensembl chr 1:48,235,476...48,324,612 		JBrowse link
G Slc2a1 solute carrier family 2 member 1 no_association ISO CTD Direct Evidence: marker/mechanism CTD
RGD		 PMID:9589670 PMID:18613291 PMID:9789717 PMID:7516306 RGD:2312306, RGD:2312290, RGD:2312289 NCBI chr 5:138,002,522...138,030,742
Ensembl chr 5:132,717,196...132,745,416 		JBrowse link
G Slc2a2 solute carrier family 2 member 2 susceptibility ISO
ISS		 DNA:SNPs (human)
DNA:point mutation:exon:p.V197I (human)
CTD Direct Evidence: marker/mechanism
OMIM:125853 | OMIM:601283 | OMIM:601407 | OMIM:603694 | OMIM:608036
ClinVar Annotator: match by term: Type 2 diabetes mellitus		 OMIM
CTD
MouseDO
ClinVar
RGD		 PMID:8027028 PMID:8063045 PMID:9354798 PMID:11810292 PMID:13480676 More... RGD:2312359, RGD:1624252 NCBI chr 2:113,537,884...113,568,422
Ensembl chr 2:111,611,774...111,639,933 		JBrowse link
G Slc2a3 solute carrier family 2 member 3 ISO protein:decreased expression:granulocyte, lymphocyte, monocyte RGD PMID:19110659 RGD:2313602 NCBI chr 4:157,632,887...157,698,034
Ensembl chr 4:155,960,946...156,025,472 		JBrowse link
G Slc2a4 solute carrier family 2 member 4 ISO
ISS		 DNA:point mutation:exon:p.V383I (human)
CTD Direct Evidence: marker/mechanism
OMIM:125853 | OMIM:601283 | OMIM:601407 | OMIM:603694 | OMIM:608036
ClinVar Annotator: match by term: Type 2 diabetes mellitus		 CTD
MouseDO
ClinVar
RGD		 PMID:1397719 PMID:1918382 PMID:7814014 PMID:11947963 PMID:17107852 More... RGD:2313625, RGD:1625188 NCBI chr10:55,164,721...55,170,289
Ensembl chr10:54,666,015...54,671,565 		JBrowse link
G Slc30a8 solute carrier family 30 member 8 susceptibility ISO CTD Direct Evidence: marker/mechanism|therapeutic
ClinVar Annotator: match by term: SLC30A8-related condition | ClinVar Annotator: match by term: Type 2 diabetes mellitus		 CTD
OMIM
ClinVar		 PMID:17293876 PMID:17460697 PMID:17463246 PMID:17463248 PMID:17463249 More... NCBI chr 7:85,481,864...85,517,255
Ensembl chr 7:83,591,993...83,626,305 		JBrowse link
G Slc9a1 solute carrier family 9 member A1 IEP mRNA, protein:decreased expression:heart RGD PMID:22009485 RGD:6771327 NCBI chr 5:150,859,412...150,913,525
Ensembl chr 5:145,576,334...145,629,624 		JBrowse link
G Slpi secretory leukocyte peptidase inhibitor ISO ClinVar Annotator: match by term: Type 2 diabetes mellitus ClinVar NCBI chr 3:173,501,573...173,503,822
Ensembl chr 3:153,082,369...153,084,453 		JBrowse link
G Smad4 SMAD family member 4 treatment IEP RGD PMID:25017203 RGD:12880049 NCBI chr18:69,518,988...69,549,684
Ensembl chr18:67,243,742...67,274,438 		JBrowse link
G Smad5 SMAD family member 5 ISO CTD Direct Evidence: therapeutic CTD PMID:20079400 NCBI chr17:7,867,640...7,896,983
Ensembl chr17:7,864,720...7,891,634 		JBrowse link
G Smc1a structural maintenance of chromosomes 1A IEP mRNA:increased expression:testis: RGD PMID:33775663 RGD:155631260 NCBI chr  X:24,582,732...24,627,462
Ensembl chr  X:21,103,282...21,148,056 		JBrowse link
G Smim43 small integral membrane protein 43 ISO CTD Direct Evidence: marker/mechanism CTD PMID:28869590 NCBI chr 2:121,304,262...121,314,779
Ensembl chr 2:119,385,754...119,385,945 		JBrowse link
G Snap25 synaptosome associated protein 25 ISO
ISS		 CTD Direct Evidence: marker/mechanism
OMIM:125853 | OMIM:601283 | OMIM:601407 | OMIM:603694 | OMIM:608036		 CTD
MouseDO		 PMID:16123366 NCBI chr 3:144,494,579...144,576,449
Ensembl chr 3:124,041,898...124,123,760 		JBrowse link
G Soat1 sterol O-acyltransferase 1 ISO mRNA:increased expression:peritoneal macrophage (mouse) RGD PMID:26606676 RGD:126925207 NCBI chr13:71,105,178...71,147,776
Ensembl chr13:68,552,317...68,597,494 		JBrowse link
G Socs3 suppressor of cytokine signaling 3 treatment ISO
IEP		 mRNA:increased expression:skeletal muscle RGD PMID:17513737 PMID:15331532 PMID:29110587 RGD:2313788, RGD:2313790, RGD:13506806 NCBI chr10:103,692,579...103,695,975
Ensembl chr10:103,193,537...103,197,787 		JBrowse link
G Sod1 superoxide dismutase 1 ISO protein:decreased expression:erythrocyte
DNA:polymorphism:intron:IVS3+35A>C (rs2234694) (human)
CTD Direct Evidence: marker/mechanism		 CTD
RGD		 PMID:15531508 PMID:19317795 PMID:18423055 PMID:16005359 RGD:2312363, RGD:2312364, RGD:1581216 NCBI chr11:42,942,742...42,948,399
Ensembl chr11:29,456,558...29,462,249 		JBrowse link
G Sod2 superoxide dismutase 2 ISO DNA:polymorphism: :p.A16V (human)
CTD Direct Evidence: marker/mechanism		 CTD
RGD		 PMID:15531508 PMID:18423055 RGD:2312364 NCBI chr 1:50,043,323...50,050,168
Ensembl chr 1:47,636,528...47,645,189 		JBrowse link
G Sod3 superoxide dismutase 3 ISO RGD PMID:15990193 RGD:1581225 NCBI chr14:62,822,865...62,828,602
Ensembl chr14:58,609,958...58,615,990 		JBrowse link
G Sorbs1 sorbin and SH3 domain containing 1 ISO DNA:SNP: :p.T228A (human) RGD PMID:11532984 RGD:1642744 NCBI chr 1:249,057,324...249,279,703
Ensembl chr 1:239,108,777...239,330,169 		JBrowse link
G Sphk1 sphingosine kinase 1 ISO RGD PMID:17265031 RGD:2311390 NCBI chr10:102,257,413...102,263,086
Ensembl chr10:101,758,711...101,764,240 		JBrowse link
G Src SRC proto-oncogene, non-receptor tyrosine kinase ISO
IMP		 protein:increased tyrosine phosphorylation:platelets RGD PMID:15542065 PMID:19230846 RGD:1601373, RGD:2307340 NCBI chr 3:166,511,616...166,559,463
Ensembl chr 3:146,091,841...146,139,476 		JBrowse link
G Srd5a1 steroid 5 alpha-reductase 1 IEP mRNA:increased expression:adrenal gland (rat) RGD PMID:17884440 RGD:4891894 NCBI chr 1:35,514,914...35,548,898
Ensembl chr 1:33,686,391...33,720,461 		JBrowse link
G Srebf1 sterol regulatory element binding transcription factor 1 susceptibility ISO
IEP		 DNA:SNPs
mRNA:increased expression:liver		 RGD PMID:18692268 PMID:19357831 RGD:2308809, RGD:2308802 NCBI chr10:45,507,152...45,529,164
Ensembl chr10:45,007,637...45,029,650 		JBrowse link
G Srebf1_v2 sterol regulatory element binding factor 1, variant 2 IEP mRNA:increased expression:liver RGD PMID:19357831 RGD:2308802
G Srebf2 sterol regulatory element binding transcription factor 2 ISO RGD PMID:15644403 RGD:1581419 NCBI chr 7:115,542,774...115,600,945
Ensembl chr 7:113,663,202...113,720,848 		JBrowse link
G St6gal1 ST6 beta-galactoside alpha-2,6-sialyltransferase 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:21874001 NCBI chr11:91,031,481...91,158,111
Ensembl chr11:77,526,837...77,653,310 		JBrowse link
G Star steroidogenic acute regulatory protein IEP mRNA:decreased expression:testis, Leydig cell (rat) RGD PMID:18481435 RGD:4889107 NCBI chr16:72,969,824...72,974,447
Ensembl chr16:66,264,807...66,271,672 		JBrowse link
G Stat3 signal transducer and activator of transcription 3 ISO protein:increased tyrosine phosphorylation:skeletal muscle RGD PMID:23043161 RGD:8694321 NCBI chr10:86,311,528...86,363,513
Ensembl chr10:85,811,218...85,863,057 		JBrowse link
G Supt5h SPT5 homolog, DSIF elongation factor subunit ISO ClinVar Annotator: match by term: Type 2 diabetes mellitus ClinVar PMID:28492532 NCBI chr 1:92,714,276...92,745,489
Ensembl chr 1:83,586,718...83,616,892 		JBrowse link
G Sycn syncollin ISO ClinVar Annotator: match by term: Type 2 diabetes mellitus ClinVar PMID:28492532 NCBI chr 1:92,950,761...92,961,077
Ensembl chr 1:83,832,102...83,833,538 		JBrowse link
G Tcf7l2 transcription factor 7 like 2 susceptibility IEP
ISO		 DNA:SNPs: :multiple (human)
DNA:SNP (human)
CTD Direct Evidence: marker/mechanism
ClinVar Annotator: match by term: Diabetes mellitus type 2, susceptibility to | ClinVar Annotator: match by term: TCF7L2-related condition | ClinVar Annotator: match by term: Type 2 diabetes mellitus		 CTD
OMIM
ClinVar
RGD		 PMID:16415884 PMID:17206141 PMID:17245407 PMID:17340123 PMID:17460697 More... RGD:2312454, RGD:2312453, RGD:2312433 NCBI chr 1:264,791,335...264,984,225
Ensembl chr 1:254,786,091...254,978,967 		JBrowse link
G Tgfb1 transforming growth factor, beta 1 ISO
IEP		 protein:increased expression:urine
mRNA,protein:increased expression:heart:		 RGD PMID:18646321 PMID:24613393 RGD:2306740, RGD:11073674 NCBI chr 1:90,324,312...90,340,627
Ensembl chr 1:81,196,532...81,212,847 		JBrowse link
G Tgfbr2 transforming growth factor, beta receptor 2 IEP protein:increased expression:aorta RGD PMID:11947899 RGD:1601600 NCBI chr 8:124,672,677...124,761,741
Ensembl chr 8:115,794,537...115,883,228 		JBrowse link
G Th tyrosine hydroxylase ISO ClinVar Annotator: match by term: Type 2 diabetes mellitus ClinVar PMID:25741868 PMID:26467025 PMID:28492532 PMID:30456822 NCBI chr 1:207,500,959...207,508,276
Ensembl chr 1:198,071,503...198,109,767 		JBrowse link
G Thada THADA, armadillo repeat containing ISO CTD Direct Evidence: marker/mechanism CTD PMID:18372903 NCBI chr 6:15,936,593...16,240,523
Ensembl chr 6:10,183,982...10,487,159 		JBrowse link
G Thbd thrombomodulin disease_progression ISO
IEP		 protein:increased expression:plasma
mRNA:decreased expression:blood vessel endothelial cell		 RGD PMID:11738074 PMID:17090405 PMID:17195062 RGD:2312458, RGD:1601648, RGD:2312457 NCBI chr 3:156,316,526...156,320,178
Ensembl chr 3:135,862,835...135,867,193 		JBrowse link
G Timm50 translocase of inner mitochondrial membrane 50 ISO ClinVar Annotator: match by term: Type 2 diabetes mellitus ClinVar PMID:28492532 NCBI chr 1:92,702,437...92,710,311
Ensembl chr 1:83,556,757...83,582,793 		JBrowse link
G Timp1 TIMP metallopeptidase inhibitor 1 ISO protein:increased expression:plasma
CTD Direct Evidence: marker/mechanism		 CTD
RGD		 PMID:16023759 PMID:16005367 RGD:1580148 NCBI chr  X:3,766,509...3,772,578
Ensembl chr  X:1,212,972...1,217,664 		JBrowse link
G Timp3 TIMP metallopeptidase inhibitor 3 disease_progression ISO
IEP		 mRNA:decreased expression:skeletal muscle
associated with Femoral Fractures;		 RGD PMID:19633828 PMID:31691506 RGD:2312470, RGD:151893486 NCBI chr 7:19,408,539...19,459,558
Ensembl chr 7:17,521,919...17,571,839 		JBrowse link
G Tjp1 tight junction protein 1 ISO protein:decreased expression:glomerulus RGD PMID:16567508 RGD:2325150 NCBI chr 1:128,260,330...128,505,018
Ensembl chr 1:118,849,838...119,094,432 		JBrowse link
G Tlr2 toll-like receptor 2 IEP mRNA:increased expression:gingiva RGD PMID:24878329 RGD:597538517 NCBI chr 2:171,499,189...171,504,831
Ensembl chr 2:169,197,419...169,206,630 		JBrowse link
G Tlr4 toll-like receptor 4 no_association ISO
IEP		 DNA:polymorphisms: :p.N299G, p.T399I (human)
protein:increased expression:monocyte
mRNA:increased expression:gingiva		 RGD PMID:14578307 PMID:16728431 PMID:19395279 PMID:19010563 PMID:24878329 RGD:2312494, RGD:2312492, RGD:2312484, RGD:2312680, RGD:597538517 NCBI chr 5:85,161,247...85,174,882
Ensembl chr 5:80,145,826...80,159,628 		JBrowse link
G Tmem18 transmembrane protein 18 ISO CTD Direct Evidence: marker/mechanism CTD PMID:28869590 NCBI chr 6:52,934,419...52,941,868
Ensembl chr 6:47,206,845...47,214,294 		JBrowse link
G Tnf tumor necrosis factor IMP
ISO		 CTD Direct Evidence: marker/mechanism CTD
RGD		 PMID:24513509 PMID:20559450 PMID:28843383 RGD:5130987, RGD:14975146 NCBI chr20:3,626,685...3,629,303
Ensembl chr20:3,622,011...3,624,629 		JBrowse link
G Tnfrsf11b TNF receptor superfamily member 11B severity ISO protein:increased expression:serum RGD PMID:22050177 RGD:7205512 NCBI chr 7:87,456,318...87,484,324
Ensembl chr 7:85,566,520...85,594,538 		JBrowse link
G Tnfrsf1a TNF receptor superfamily member 1A IEP
ISO		 mRNA:increased expression:coronary artery (rat)
CTD Direct Evidence: marker/mechanism		 CTD
RGD		 PMID:11882518 PMID:20559450 RGD:5130987 NCBI chr 4:159,837,119...159,849,817
Ensembl chr 4:158,150,820...158,163,591 		JBrowse link
G Tnfrsf1b TNF receptor superfamily member 1B ISO CTD Direct Evidence: marker/mechanism CTD PMID:11882518 NCBI chr 5:162,356,250...162,387,411
Ensembl chr 5:157,070,642...157,104,206 		JBrowse link
G Trpc1 transient receptor potential cation channel, subfamily C, member 1 IEP protein:increased expression:artery smooth muscle RGD PMID:20337661 RGD:7247596 NCBI chr 8:105,142,931...105,193,842
Ensembl chr 8:96,263,329...96,314,276 		JBrowse link
G Trpc6 transient receptor potential cation channel, subfamily C, member 6 IEP protein:increased expression:artery smooth muscle RGD PMID:20337661 RGD:7247596 NCBI chr 8:14,044,216...14,148,808
Ensembl chr 8:5,758,935...5,828,092 		JBrowse link
G Ttc9b tetratricopeptide repeat domain 9B ISO ClinVar Annotator: match by term: Type 2 diabetes mellitus ClinVar PMID:28492532 NCBI chr 1:92,081,026...92,083,208
Ensembl chr 1:82,953,434...82,955,616 		JBrowse link
G Ube2e2 ubiquitin-conjugating enzyme E2E 2 susceptibility ISO CTD Direct Evidence: marker/mechanism
associated with Environmental Illness; DNA:SNP:: (rs1496653) (human)		 CTD
RGD		 PMID:20818381 PMID:27281273 RGD:401850598 NCBI chr15:9,411,067...9,688,731
Ensembl chr15:6,980,474...7,257,532 		JBrowse link
G Ucp1 uncoupling protein 1 ISO DNA:polymorphisms:5' utr, exon:-112A>C (rs10011540), p.M229L (human) RGD PMID:11317671 RGD:2313631 NCBI chr19:41,713,350...41,721,421
Ensembl chr19:24,808,783...24,816,852 		JBrowse link
G Ucp2 uncoupling protein 2 no_association IDA
ISO
IEP		 associated with Obesity
mRNA:increased expression:brown fat, white fat, skeletal muscle
DNA:polymorphism:exon (human)
CTD Direct Evidence: marker/mechanism		 CTD
RGD		 PMID:15562023 PMID:16123366 PMID:15356383 PMID:11587528 PMID:10382588 More... RGD:2313517, RGD:2313630, RGD:2313525, RGD:7175300, RGD:737760 NCBI chr 1:164,251,373...164,257,742
Ensembl chr 1:154,839,209...154,845,611 		JBrowse link
G Ucp3 uncoupling protein 3 no_association
susceptibility		 ISO
IDA		 mRNA:altered expression:white fat, skeletal muscle
DNA:SNP:exon:p.V102I (human)
associated with Obesity
DNA:polymorphism:promoter:-55C>T (human)
protein:decreased expression:skeletal muscle
associated with Obesity;DNA:SNPs:exon, 3' utr:rs1800006, rs647126 (human)
ClinVar Annotator: match by term: UCP3 POLYMORPHISM G/A		 ClinVar
RGD		 PMID:9769326 PMID:25741868 PMID:28492532 PMID:11587528 PMID:9769326 More... RGD:2313630, RGD:1625189, RGD:2313517, RGD:2313522, RGD:2313521, RGD:2313523, RGD:2313511 NCBI chr 1:164,227,910...164,240,893
Ensembl chr 1:154,815,777...154,828,762 		JBrowse link
G Ugt1a1 UDP glucuronosyltransferase family 1 member A1 IEP mRNA,protein:increased expression,increased activity:intestine, colon: RGD PMID:23545594 RGD:10769362 NCBI chr 9:96,249,143...96,256,264
Ensembl chr 9:88,713,184...88,808,465 		JBrowse link
G Ugt1a6 UDP glucuronosyltransferase family 1 member A6 IEP mRNA,protein:increased expression,increased activity:intestine, colon: RGD PMID:23545594 RGD:10769362 NCBI chr 9:96,195,018...96,256,264
Ensembl chr 9:88,713,184...88,808,465 		JBrowse link
G Ugt1a7c UDP glucuronosyltransferase 1 family, polypeptide A7C IEP mRNA,protein:increased expression,increased activity:intestine, colon: RGD PMID:23545594 RGD:10769362 NCBI chr 9:96,187,382...96,256,264
Ensembl chr 9:88,713,184...88,808,465 		JBrowse link
G Usf1 upstream transcription factor 1 no_association
susceptibility		 ISO DNA:SNPs:intron, 3' utr:multiple (human)
DNA:SNP: :rs3737787 (human)
DNA:SNP: :rs2073658 (human)		 RGD PMID:16186412 PMID:18593823 PMID:18445538 RGD:2313794, RGD:2313792, RGD:2313793 NCBI chr13:86,377,679...86,385,523
Ensembl chr13:83,822,035...83,854,885 		JBrowse link
G Usp48 ubiquitin specific peptidase 48 ISO CTD Direct Evidence: marker/mechanism CTD PMID:30718926 NCBI chr 5:155,083,520...155,151,208
Ensembl chr 5:149,800,179...149,867,719 		JBrowse link
G Uts2 urotensin 2 susceptibility ISO DNA:polymorphism
protein:increased expression:skeletal muscle
protein:increased expression:plasma
DNA:polymorphism: :p.S89N		 RGD PMID:18067077 PMID:19323985 PMID:15476950 PMID:15476949 RGD:2306799, RGD:2306785, RGD:2306806, RGD:2306807 NCBI chr 5:166,725,471...166,739,063
Ensembl chr 5:161,450,846...161,456,237 		JBrowse link
G Uts2r urotensin 2 receptor ISO mRNA:increased expression:skeletal muscle RGD PMID:19323985 RGD:2306785 NCBI chr10:106,936,398...106,937,558
Ensembl chr10:106,438,092...106,439,252 		JBrowse link
G Vcam1 vascular cell adhesion molecule 1 ISO protein:increased expression:serum RGD PMID:18619052 RGD:2312765 NCBI chr 2:206,723,050...206,742,783
Ensembl chr 2:204,038,114...204,057,958 		JBrowse link
G Vdr vitamin D receptor ISO GAD PMID:15118671 RGD:1331525 NCBI chr 7:130,864,764...130,916,757
Ensembl chr 7:128,987,981...129,037,677 		JBrowse link
G Vegfa vascular endothelial growth factor A ISO mRNA, protein:increased expression:ventricle myocardium RGD PMID:16139132 RGD:2313728 NCBI chr 9:22,452,854...22,468,194
Ensembl chr 9:14,955,300...14,970,641 		JBrowse link
G Vps26a VPS26 retromer complex component A susceptibility ISO CTD Direct Evidence: marker/mechanism
associated with Environmental Illness;DNA:SNP:: (rs12242953) (human)		 CTD
RGD		 PMID:21874001 PMID:27281273 RGD:401850598 NCBI chr20:30,947,018...30,976,964
Ensembl chr20:30,404,325...30,434,131 		JBrowse link
G Wfs1 wolframin ER transmembrane glycoprotein no_association
susceptibility		 ISO DNA:SNP: :rs752854 (human)
DNA:SNPs: :rs734312, rs752854, rs10010131 (human)
DNA:SNPs, haplotype: :rs734312, rs752854, rs10010131 (human)
CTD Direct Evidence: marker/mechanism
ClinVar Annotator: match by term: DIABETES MELLITUS, TYPE 2, PROTECTION AGAINST | ClinVar Annotator: match by term: Diabetes mellitus type 2, susceptibility to | ClinVar Annotator: match by term: Type 2 diabetes mellitus | ClinVar Annotator: match by term: Type II diabetes mellitus
ClinVar Annotator: match by term: DIABETES MELLITUS, TYPE 2, PROTECTION AGAINST | ClinVar Annotator: match by term: Diabetes mellitus, noninsulin-dependent, late onset | ClinVar Annotator: match by term: HYPERTENSION, INSULIN RESISTANCE-RELATED, SUSCEPTIBILITY TO | ClinVar Annotator: match by term: Type 2 diabetes mellitus | ClinVar Annotator: match by term: Type II diabetes mellitus
ClinVar Annotator: match by term: DIABETES MELLITUS, TYPE 2, PROTECTION AGAINST | ClinVar Annotator: match by term: Diabetes mellitus type 2, susceptibility to | ClinVar Annotator: match by term: Diabetes mellitus, noninsulin-dependent, late onset | ClinVar Annotator: match by term: Type 2 diabetes mellitus | ClinVar Annotator: match by term: Type II diabetes mellitus
ClinVar Annotator: match by term: DIABETES MELLITUS, TYPE 2, PROTECTION AGAINST | ClinVar Annotator: match by term: Diabetes mellitus, noninsulin-dependent, late onset | ClinVar Annotator: match by term: Type 2 diabetes mellitus | ClinVar Annotator: match by term: Type II diabetes mellitus		 OMIM
CTD
ClinVar
RGD		 PMID:1161832 PMID:3126496 PMID:3442652 PMID:3478949 PMID:3620803 More... RGD:8694394, RGD:8694399, RGD:8694400, RGD:8694401, RGD:8694405 NCBI chr14:78,035,205...78,059,718
Ensembl chr14:73,810,404...73,835,602 		JBrowse link
G Wrn WRN RecQ like helicase ISO ClinVar Annotator: match by term: Type 2 diabetes mellitus ClinVar
RGD		 PMID:20443122 PMID:25741868 PMID:28492532 PMID:18295300 RGD:10042987 NCBI chr16:65,466,552...65,602,951
Ensembl chr16:58,763,504...58,895,450 		JBrowse link
G Xrcc1 X-ray repair cross complementing 1 susceptibility ISO DNA:SNP:cd: p.R399Q G>A (rs25487) (human) RGD PMID:30472145 RGD:401827275 NCBI chr 1:89,268,721...89,296,619
Ensembl chr 1:80,141,207...80,168,701 		JBrowse link
G Zc3hc1 zinc finger, C3HC-type containing 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:28869590 NCBI chr 4:59,957,402...59,979,336
Ensembl chr 4:58,989,987...59,011,933 		JBrowse link
G Zfand3 zinc finger AN1-type containing 3 ISO CTD Direct Evidence: marker/mechanism CTD PMID:22158537 NCBI chr20:8,084,898...8,281,093
Ensembl chr20:8,082,200...8,279,616 		JBrowse link
G Zfp11 zinc finger protein 11 ISO ClinVar Annotator: match by term: Type 2 diabetes mellitus ClinVar PMID:28492532 NCBI chr12:32,664,312...32,676,940
Ensembl chr12:27,028,115...27,041,365 		JBrowse link
G Zfp36 zinc finger protein 36 ISO ClinVar Annotator: match by term: Type 2 diabetes mellitus ClinVar PMID:28492532 NCBI chr 1:92,796,628...92,799,108
Ensembl chr 1:83,669,084...83,671,564 		JBrowse link
G Znf780b zinc finger protein 780B ISO ClinVar Annotator: match by term: Type 2 diabetes mellitus ClinVar PMID:28492532 NCBI chr 1:92,136,761...92,159,076
Ensembl chr 1:83,009,189...83,082,107 		JBrowse link
background diabetic retinopathy term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G A2m alpha-2-macroglobulin treatment ISO RGD PMID:10848441 RGD:10046010 NCBI chr 4:156,570,163...156,619,870
Ensembl chr 4:154,897,877...154,947,786 		JBrowse link
G Cat catalase ISO associated withDiabetes Mellitus, Type 2; mRNA,protein:decreased expression, decreased activity:blood,l serum: RGD PMID:24092995 RGD:9068931 NCBI chr 3:110,297,340...110,329,526
Ensembl chr 3:89,842,399...89,874,478 		JBrowse link
G Flt1 Fms related receptor tyrosine kinase 1 ISO protein:decreased expression:aqueous humor: RGD PMID:23853629 RGD:10402120 NCBI chr12:12,333,050...12,504,750
Ensembl chr12:7,297,292...7,468,626 		JBrowse link
G Map3k8 mitogen-activated protein kinase kinase kinase 8 ISO protein:increased activity:serum: RGD PMID:28724746 RGD:151356966 NCBI chr17:58,078,175...58,098,455
Ensembl chr17:53,383,131...53,403,216 		JBrowse link
G Pdgfb platelet derived growth factor subunit B ISO protein:decreased expression:vitreous: RGD PMID:19799585 RGD:10449447 NCBI chr 7:113,419,882...113,438,343
Ensembl chr 7:111,540,345...111,557,984 		JBrowse link
Cleft Palate, Proliferative Retinopathy, and Developmental Delay term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Lrrc32 leucine rich repeat containing 32 ISO ClinVar Annotator: match by term: Cleft palate, proliferative retinopathy, and developmental delay OMIM
ClinVar		 PMID:25741868 PMID:30976112 NCBI chr 1:162,196,995...162,209,563
Ensembl chr 1:152,786,511...152,798,373 		JBrowse link
diabetic angiopathy term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ace angiotensin I converting enzyme ISO ClinVar Annotator: match by term: Microvascular complications of diabetes, susceptibility to, 3 ClinVar PMID:1313972 PMID:1319114 PMID:1328889 PMID:1386652 PMID:1976655 More... NCBI chr10:91,410,129...91,430,246
Ensembl chr10:90,910,316...90,931,131 		JBrowse link
G Adcy3 adenylate cyclase 3 ISO CTD Direct Evidence: marker/mechanism CTD PMID:25381014 NCBI chr 6:32,819,602...32,923,174
Ensembl chr 6:27,124,828...27,203,686 		JBrowse link
G Adcy8 adenylate cyclase 8 ISO CTD Direct Evidence: marker/mechanism CTD PMID:25381014 NCBI chr 7:98,306,434...98,555,687
Ensembl chr 7:96,417,324...96,665,911 		JBrowse link
G Ager advanced glycosylation end product-specific receptor ISO CTD Direct Evidence: marker/mechanism CTD PMID:20372816 NCBI chr20:4,152,758...4,155,956
Ensembl chr20:4,147,890...4,151,078 		JBrowse link
G Alb albumin ISO CTD Direct Evidence: marker/mechanism CTD PMID:19733855 NCBI chr14:17,891,564...17,907,043
Ensembl chr14:17,607,381...17,622,836 		JBrowse link
G Ass1 argininosuccinate synthase 1 ISO CTD Direct Evidence: therapeutic CTD PMID:25033204 NCBI chr 3:35,144,765...35,194,632
Ensembl chr 3:14,747,368...14,796,903 		JBrowse link
G Bdkrb1 bradykinin receptor B1 IMP RGD PMID:15878326 RGD:7241570 NCBI chr 6:130,275,631...130,284,968
Ensembl chr 6:124,510,870...124,513,747 		JBrowse link
G Casp3 caspase 3 ISO CTD Direct Evidence: marker/mechanism CTD PMID:25381014 NCBI chr16:52,395,539...52,413,794
Ensembl chr16:45,662,910...45,684,648 		JBrowse link
G Ccl2 C-C motif chemokine ligand 2 treatment IDA associated with Diabetes Mellitus, Experimental RGD PMID:23154660 RGD:11526153 NCBI chr10:67,503,077...67,504,875
Ensembl chr10:67,005,424...67,007,226 		JBrowse link
G Cd28 Cd28 molecule ISO associated with Diabetes Mellitus, Insulin-Dependent;protein:decreased expression:T cell RGD PMID:15504310 RGD:2307197 NCBI chr 9:69,660,316...69,689,192
Ensembl chr 9:62,166,192...62,194,685 		JBrowse link
G Cd40lg CD40 ligand ISO protein:increased expression:serum RGD PMID:14963650 RGD:2314223 NCBI chr  X:140,164,341...140,176,057
Ensembl chr  X:135,126,969...135,138,306 		JBrowse link
G Crem cAMP responsive element modulator ISO CTD Direct Evidence: marker/mechanism CTD PMID:25381014 NCBI chr17:58,932,011...59,001,160
Ensembl chr17:54,239,030...54,305,989 		JBrowse link
G Cxcl12 C-X-C motif chemokine ligand 12 susceptibility ISO associated with Diabetic Foot;DNA:polymorphism:3' utr (human) RGD PMID:16723689 RGD:2306558 NCBI chr 4:152,060,781...152,073,628
Ensembl chr 4:150,388,325...150,401,168 		JBrowse link
G Epo erythropoietin ISO ClinVar Annotator: match by term: Microvascular complications of diabetes, susceptibility to, 2 OMIM
ClinVar		 PMID:18458324 NCBI chr12:24,841,285...24,844,725
Ensembl chr12:19,204,508...19,207,946 		JBrowse link
G F3 coagulation factor III, tissue factor ISO associated with Diabetes Mellitus, Non-Insulin-Dependent
protein:increased expression:plasma		 RGD PMID:16371118 PMID:9285207 RGD:2313861, RGD:2313868 NCBI chr 2:212,511,675...212,523,375
Ensembl chr 2:209,826,959...209,838,668 		JBrowse link
G Fas Fas cell surface death receptor ISO associated with Diabetes Mellitus, Non-Insulin-Dependent RGD PMID:15803113 RGD:2315753 NCBI chr 1:241,212,155...241,245,774
Ensembl chr 1:231,798,960...231,832,591 		JBrowse link
G Faslg Fas ligand ISO associated with Diabetes Mellitus, Non-Insulin-Dependent
CTD Direct Evidence: marker/mechanism		 CTD
RGD		 PMID:25381014 PMID:15803113 RGD:2315753 NCBI chr13:76,680,885...76,706,042
Ensembl chr13:74,154,954...74,162,215 		JBrowse link
G Fn1 fibronectin 1 IDA RGD PMID:12716757 RGD:1601179 NCBI chr 9:80,645,507...80,714,200
Ensembl chr 9:73,196,044...73,264,678 		JBrowse link
G Gch1 GTP cyclohydrolase 1 ISO associated with type 2 diabetes mellitus;DNA:SNV: :C59038T (human) RGD PMID:19515581 RGD:329961327 NCBI chr15:22,884,006...22,917,412
Ensembl chr15:20,402,527...20,437,698 		JBrowse link
G Gp1ba glycoprotein Ib platelet subunit alpha ISO RGD PMID:21411989 RGD:7242686 NCBI chr10:55,831,901...55,856,729
Ensembl chr10:55,352,899...55,356,774 		JBrowse link
G Gpx1 glutathione peroxidase 1 ISO cardiovascular complications in type 2 diabetics RGD PMID:16338763 RGD:1600708 NCBI chr 8:117,905,462...117,906,588
Ensembl chr 8:109,026,905...109,028,024 		JBrowse link
G Gsr glutathione-disulfide reductase ISO cardiovascular complications in type 2 diabetics RGD PMID:16338763 RGD:1600708 NCBI chr16:65,185,574...65,228,742
Ensembl chr16:58,482,505...58,525,661 		JBrowse link
G Hfe homeostatic iron regulator ISO ClinVar Annotator: match by term: MICROVASCULAR COMPLICATIONS OF DIABETES, SUSCEPTIBILITY TO, 7 | ClinVar Annotator: match by term: Microvascular complications of diabetes, susceptibility to, 7 ClinVar PMID:678784 PMID:8696333 PMID:8896549 PMID:8896550 PMID:8931958 More... NCBI chr17:41,841,302...41,849,359
Ensembl chr17:41,413,451...41,421,502 		JBrowse link
G Hmox1 heme oxygenase 1 ISO CTD Direct Evidence: therapeutic CTD PMID:16959961 NCBI chr19:13,452,365...13,479,823
Ensembl chr19:13,467,244...13,474,079 		JBrowse link
G Hp haptoglobin ISO CTD Direct Evidence: marker/mechanism CTD PMID:16597321 NCBI chr19:54,449,151...54,453,701
Ensembl chr19:37,539,627...37,544,523 		JBrowse link
G Icam1 intercellular adhesion molecule 1 IDA
ISO		 associated with Diabetes Mellitus, Experimental
associated with Diabetes Mellitus, Experimental;mRNA:increased expression:aorta		 RGD PMID:18796303 PMID:18093596 RGD:2313473, RGD:2306988 NCBI chr 8:27,829,688...27,841,618
Ensembl chr 8:19,553,645...19,565,438 		JBrowse link
G Igfbp1 insulin-like growth factor binding protein 1 ISO DNA:SNPs RGD PMID:16306374 RGD:1625238 NCBI chr14:86,261,277...86,266,344
Ensembl chr14:82,047,415...82,052,482 		JBrowse link
G Il1rn interleukin 1 receptor antagonist ISO ClinVar Annotator: match by term: Microvascular complications of diabetes, susceptibility to, 4 OMIM
ClinVar		 PMID:25741868 PMID:28492532 NCBI chr 3:27,509,836...27,525,738
Ensembl chr 3:7,111,550...7,127,445 		JBrowse link
G Itgam integrin subunit alpha M ISO protein:increased expression:neutrophil (human) RGD PMID:18496641 RGD:329901826 NCBI chr 1:192,089,496...192,139,947
Ensembl chr 1:182,659,000...182,709,503 		JBrowse link
G Mmp14 matrix metallopeptidase 14 ISO RGD PMID:12477149 RGD:1582581 NCBI chr15:31,857,824...31,867,049
Ensembl chr15:27,887,727...27,899,864 		JBrowse link
G Mthfr methylenetetrahydrofolate reductase ISO CTD Direct Evidence: marker/mechanism CTD PMID:16681562 NCBI chr 5:163,748,346...163,768,141
Ensembl chr 5:158,465,296...158,483,797 		JBrowse link
G Nos2 nitric oxide synthase 2 IEP
IMP		 associated with Diabetes Mellitus, Experimental; protein:increased expression:cochlea RGD PMID:19241604 PMID:19587355 RGD:4891384, RGD:2313210 NCBI chr10:64,313,335...64,349,221
Ensembl chr10:63,815,308...63,851,210 		JBrowse link
G Nos3 nitric oxide synthase 3 treatment IEP
ISO		 associated with Diabetes Mellitus, Experimental; protein:increased expression:cochlea
CTD Direct Evidence: marker/mechanism		 CTD
RGD		 PMID:12124201 PMID:19241604 PMID:29329611 RGD:4891384, RGD:13504708 NCBI chr 4:11,686,088...11,706,604
Ensembl chr 4:10,793,834...10,814,166 		JBrowse link
G Pecam1 platelet and endothelial cell adhesion molecule 1 ISO associated with Diabetes Mellitus, Experimental;protein:increased tyrosine phosphorylation:conceptus RGD PMID:10329590 RGD:2311657 NCBI chr10:92,090,263...92,152,002
Ensembl chr10:91,590,521...91,652,116 		JBrowse link
G Plat plasminogen activator, tissue type ISO associated with Diabetes Mellitus, Non-Insulin-Dependent RGD PMID:18945481 RGD:2311663 NCBI chr16:75,943,061...76,022,037
Ensembl chr16:69,240,585...69,268,223 		JBrowse link
G Pon1 paraoxonase 1 ISO associated with Diabetes Mellitus;DNA:polymorphisms: p.L55M, p.Q192R (human)
ClinVar Annotator: match by term: RETINOPATHY, DIABETIC, SUSCEPTIBILITY TO		 ClinVar
RGD		 PMID:9011577 PMID:9661650 PMID:11335891 PMID:11788650 PMID:11889198 More... RGD:2313270 NCBI chr 4:34,261,312...34,292,327
Ensembl chr 4:33,294,722...33,321,360 		JBrowse link
G Ptk2b protein tyrosine kinase 2 beta treatment IDA associated with Diabetes Mellitus, Type 2 RGD PMID:21926342 RGD:10041069 NCBI chr15:44,536,275...44,656,754
Ensembl chr15:40,360,723...40,481,282 		JBrowse link
G Rbp4 retinol binding protein 4 disease_progression ISO protein:increased expression:blood serum (human) RGD PMID:33294897 RGD:329853310 NCBI chr 1:245,306,349...245,313,551
Ensembl chr 1:235,893,917...235,901,399 		JBrowse link
G Rela RELA proto-oncogene, NF-kB subunit ISO CTD Direct Evidence: marker/mechanism CTD PMID:25381014 NCBI chr 1:212,354,336...212,364,815
Ensembl chr 1:202,924,945...202,935,484 		JBrowse link
G RT1-Db1 RT1 class II, locus Db1 susceptibility ISO associated with Diabetes Mellitus Type 1;DNA:polymorphism: :HLA-DRB1*03:01(human) RGD PMID:23376458 RGD:7365114 NCBI chr20:4,550,594...4,560,182
Ensembl chr20:4,548,666...4,558,258 		JBrowse link
G Serpine1 serpin family E member 1 susceptibility ISO associated with Diabetes Mellitus, Type 2;DNA:deletion, haplotype:promoter:g.-676_-674delG (human) RGD PMID:9844142 RGD:8547700 NCBI chr12:25,237,977...25,248,356
Ensembl chr12:19,601,272...19,611,657 		JBrowse link
G Serpinf1 serpin family F member 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:25381014 NCBI chr10:60,748,504...60,760,898
Ensembl chr10:60,249,708...60,262,646 		JBrowse link
G Sod1 superoxide dismutase 1 ISO associated with Diabetes Mellitus, Non-Insulin-Dependent RGD PMID:16338763 RGD:1600708 NCBI chr11:42,942,742...42,948,399
Ensembl chr11:29,456,558...29,462,249 		JBrowse link
G Sod2 superoxide dismutase 2 ISO ClinVar Annotator: match by term: Microvascular complications of diabetes, susceptibility to, 6 OMIM
ClinVar		 PMID:8633092 PMID:10425186 PMID:12624725 PMID:15591282 PMID:16538174 More... NCBI chr 1:50,043,323...50,050,168
Ensembl chr 1:47,636,528...47,645,189 		JBrowse link
G Sparc secreted protein acidic and cysteine rich IEP associated with Diabetes Mellitus, Experimental;mRNA, protein:increased expression:mesentery, blood vessel RGD PMID:10625572 RGD:2300063 NCBI chr10:40,017,065...40,038,816
Ensembl chr10:39,516,406...39,538,396 		JBrowse link
G Thbs1 thrombospondin 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:25381014 NCBI chr 3:125,510,250...125,525,402
Ensembl chr 3:105,056,292...105,071,440 		JBrowse link
G Thbs2 thrombospondin 2 ISO CTD Direct Evidence: marker/mechanism CTD PMID:25381014 NCBI chr 1:64,343,523...64,372,918
Ensembl chr 1:55,670,394...55,699,789 		JBrowse link
G Tnf tumor necrosis factor susceptibility ISO associated with Diabetes Mellitus, Non-Insulin-Dependent;DNA:polymorphism:promoter:c.-308G>A (human) RGD PMID:18575614 RGD:2313255 NCBI chr20:3,626,685...3,629,303
Ensembl chr20:3,622,011...3,624,629 		JBrowse link
G Vegfa vascular endothelial growth factor A IEP
ISO		 protein:increased expression:cochlea:
ClinVar Annotator: match by term: Microvascular complications of diabetes, susceptibility to, 1 | ClinVar Annotator: match by term: VEGFA-related condition		 ClinVar
OMIM
RGD		 PMID:11978667 PMID:25741868 PMID:28492532 PMID:19241604 RGD:4891384 NCBI chr 9:22,452,854...22,468,194
Ensembl chr 9:14,955,300...14,970,641 		JBrowse link
Diabetic Foot term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Adipoq adiponectin, C1Q and collagen domain containing ISO protein:decreased expression:plasma RGD PMID:20836881 RGD:5686889 NCBI chr11:91,226,524...91,240,244
Ensembl chr11:77,721,912...77,735,564 		JBrowse link
G Ager advanced glycosylation end product-specific receptor ISO associated with Diabetes Mellitus, Type 2;protein:decreased expression:blood RGD PMID:21941211 RGD:6767555 NCBI chr20:4,152,758...4,155,956
Ensembl chr20:4,147,890...4,151,078 		JBrowse link
G Crp C-reactive protein disease_progression ISO protein:increased expression:blood: RGD PMID:22712631 RGD:6906887 NCBI chr13:87,694,062...87,695,978
Ensembl chr13:85,124,977...85,175,178 		JBrowse link
G Gja1 gap junction protein, alpha 1 ISO protein:increased expression:dermis RGD PMID:22455314 RGD:7207269 NCBI chr20:36,302,490...36,315,010
Ensembl chr20:35,755,991...35,768,582 		JBrowse link
G H19 H19 imprinted maternally expressed transcript ameliorates ISO RNA:increased expression:foot (human) RGD PMID:33174326 PMID:33174326 RGD:156451663, RGD:156451663 NCBI chr 1:207,160,175...207,162,851
Ensembl chr 1:197,730,698...197,733,134 		JBrowse link
G Hif1a hypoxia inducible factor 1 subunit alpha ISO mRNA,protein:decreased expression:blood serum, foot (human) RGD PMID:34293021 RGD:155260332 NCBI chr 6:98,357,788...98,405,068
Ensembl chr 6:92,624,390...92,669,261 		JBrowse link
G Hspa1b heat shock protein family A (Hsp70) member 1B severity ISO DNA:polymorphism: :1538G>A (human) RGD PMID:19731315 RGD:8662463 NCBI chr20:3,859,756...3,863,800
Ensembl chr20:3,856,006...3,873,240
Ensembl chr20:3,856,006...3,873,240 		JBrowse link
G Igf1 insulin-like growth factor 1 ISO protein:decreased expression:fibroblast of dermis,stratum basale of epidermis: RGD PMID:10727985 RGD:8549356 NCBI chr 7:24,169,608...24,249,446
Ensembl chr 7:22,282,930...22,359,296 		JBrowse link
G Il15 interleukin 15 ISO associated with Diabetes Mellitus, Non-Insulin-Dependent;protein:decreased expression:dermis, endothelial cell RGD PMID:17014667 RGD:2313575 NCBI chr19:42,536,160...42,611,349
Ensembl chr19:25,640,251...25,706,820 		JBrowse link
G Itgam integrin subunit alpha M ISO protein:increased expression:pes (human) RGD PMID:37087778 RGD:329853756 NCBI chr 1:192,089,496...192,139,947
Ensembl chr 1:182,659,000...182,709,503 		JBrowse link
G Mbl2 mannose binding lectin 2 ISO protein:increased expression:serum: RGD PMID:19997692 RGD:8694068 NCBI chr 1:237,429,873...237,465,567 JBrowse link
G Mir17 microRNA 17 ISO RGD PMID:36333728 RGD:329349308 NCBI chr15:98,587,848...98,587,931
Ensembl chr15:92,180,629...92,180,712 		JBrowse link
G Mir210 microRNA 210 ISO miRNA:increased expression:blood serum, foot (human) RGD PMID:34293021 RGD:155260332 NCBI chr 1:205,755,923...205,756,032
Ensembl chr 1:196,326,337...196,326,454 		JBrowse link
G Mmp9 matrix metallopeptidase 9 severity ISO RGD PMID:22688339 RGD:8547813 NCBI chr 3:174,103,474...174,111,434
Ensembl chr 3:153,683,858...153,692,120 		JBrowse link
G Notch1 notch receptor 1 ISO protein:increased expression:skin, epidermis: RGD PMID:30886104 RGD:155646129 NCBI chr 3:29,676,040...29,721,613
Ensembl chr 3:9,278,086...9,323,531 		JBrowse link
G Plat plasminogen activator, tissue type ISO RGD PMID:17275886 RGD:2311669 NCBI chr16:75,943,061...76,022,037
Ensembl chr16:69,240,585...69,268,223 		JBrowse link
G Ptx3 pentraxin 3 ISO protein:decreased expression:plasma (human) RGD PMID:30767386 RGD:38501100 NCBI chr 2:152,797,563...152,803,372
Ensembl chr 2:150,487,513...150,493,323 		JBrowse link
G Tlr4 toll-like receptor 4 susceptibility ISO DNA:SNPs,haplotype: :rs4986790,rs4986791,rs10759931,rs1927911(human); RGD PMID:23936790 RGD:7777174 NCBI chr 5:85,161,247...85,174,882
Ensembl chr 5:80,145,826...80,159,628 		JBrowse link
diabetic retinopathy term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ace angiotensin I converting enzyme susceptibility
no_association		 ISO associated with Diabetes Mellitus, Type 2;protein:increased expression:serum (human)
associated with Diabetes Mellitus, Type 2;DNA:snp:exon:g.2350G>A (rs4343) (human)
associated with Diabetes Mellitus, Type 1;DNA:deletion:intron:IVS16+1464-1751del (human)
associated with Diabetes Mellitus, Type 2;DNA:deletion:intron:IVS16+1464-1751del (human)		 GAD
RGD		 PMID:15118671 PMID:2157294 PMID:23065222 PMID:7729604 PMID:11106834 RGD:1331525, RGD:8142360, RGD:7829794, RGD:7829780, RGD:7829783 NCBI chr10:91,410,129...91,430,246
Ensembl chr10:90,910,316...90,931,131 		JBrowse link
G Ace2 angiotensin converting enzyme 2 treatment ISO associated with Diabetes Mellitus, Experimental
human gene in a mouse model
CTD Direct Evidence: therapeutic		 CTD
RGD		 PMID:31380462 PMID:21792177 PMID:31380462 RGD:8548900, RGD:40818278 NCBI chr  X:33,925,458...33,972,851
Ensembl chr  X:30,293,589...30,340,977 		JBrowse link
G Acp1 acid phosphatase 1 ISO associated with Diabetes Mellitus, Insulin-Dependent RGD PMID:12495297 RGD:2313184 NCBI chr 6:53,233,937...53,249,576
Ensembl chr 6:47,506,380...47,522,021 		JBrowse link
G Adipoq adiponectin, C1Q and collagen domain containing disease_progression ISO associated with Diabetes Mellitus, Type 2;DNA:SNP: :g.45T>G (human)
associated with Diabetes Mellitus, Type 2;protein:increased expression:serum		 RGD PMID:24655058 PMID:17970779 RGD:8694412, RGD:8694475 NCBI chr11:91,226,524...91,240,244
Ensembl chr11:77,721,912...77,735,564 		JBrowse link
G Adm adrenomedullin ISO associated with Diabetes Mellitus, Non-Insulin-Dependent;protein:increased expression:plasma RGD PMID:19216096 RGD:2313312 NCBI chr 1:174,164,178...174,182,372
Ensembl chr 1:164,745,466...164,747,654 		JBrowse link
G Adrb3 adrenoceptor beta 3 ISO associated with Diabetes Mellitus, Type 2; DNA:missense mutation:cds:p.W64R rs4994 (human) RGD PMID:9313761 RGD:5684400 NCBI chr16:71,544,603...71,547,410
Ensembl chr16:64,841,788...64,844,552 		JBrowse link
G Ager advanced glycosylation end product-specific receptor no_association
treatment
severity
susceptibility		 ISO
IDA
IEP		 associated with Diabetes Mellitus, Type 2;DNA:polymorphisms: :p.G82S, 1704G>T, 2184A>G (human)
associated with Diabetes Mellitus, Experimental
associated with Diabetes Mellitus, Type 2;DNA:SNP: :2245G>A (human)
associated with Diabetes Mellitus, Type 2;DNA:SNP:promoter:-429T>C (human)
associated with Diabetes Mellitus, Type 2;DNA:SNP:promoter:-374T>A, - 429T>C (human)
associated with Diabetes Mellitus, Type 2;DNA:SNP:promoter:-374T>A (human)
associated with Diabetes Mellitus, Type 1;DNA:SNP:promoter:-374T>A (human)
protein:increased expression:retina inner nuclear layer, retinal ganglion cell (rat)
associated with Diabetes Mellitus, Type 2;DNA:polymorphisms:promoter, cds, intron:g.-443T>C, p.G82S, g.1704G>T (rs1800625, rs2070600, rs184003) (human)
associated with Diabetes Mellitus, Type 2;DNA:missense mutation, snp, haplotype:cds, intron:p.G82S, g.1704G>T (human)
associated with Diabetes Mellitus, Type 2;protein:increased expression:serum		 GAD
RGD		 PMID:15118671 PMID:22427038 PMID:22171162 PMID:22116960 PMID:11375354 More... RGD:1331525, RGD:8695983, RGD:8695979, RGD:8695967, RGD:8695966, RGD:8695965, RGD:8695958, RGD:8695958, RGD:7244369, RGD:7244248, RGD:7244176, RGD:7244175, RGD:7244174 NCBI chr20:4,152,758...4,155,956
Ensembl chr20:4,147,890...4,151,078 		JBrowse link
G Agt angiotensinogen treatment ISO
IMP		 associated with Diabetes Mellitus, Type 1;DNA:polymorphism: :p.M235T (human)
CTD Direct Evidence: marker/mechanism
associated with Diabetes Mellitus, Experimental		 CTD
RGD		 PMID:15387897 PMID:10862638 PMID:21792177 RGD:8548872, RGD:8548900 NCBI chr19:69,426,540...69,447,017
Ensembl chr19:52,529,185...52,540,977 		JBrowse link
G Agtr1a angiotensin II receptor, type 1a ISO CTD Direct Evidence: marker/mechanism CTD PMID:16601577 NCBI chr17:34,383,397...34,435,523
Ensembl chr17:34,174,429...34,226,946 		JBrowse link
G Akr1b1 aldo-keto reductase family 1 member B1 no_association
susceptibility		 IDA
IEP
ISO		 associated with Diabetes Mellitus, Experimental
protein:increased expression:retinal astrocyte (rat)
associated with Diabetes Mellitus, Type 2;DNA:promoter:repeat:g.-2008(AC)n (rs35839483) (human)
associated with Diabetes Mellitus, Type 2;DNA:snp:promoter:g.-106C>T (human)
associated with Diabetes Mellitus;DNA:repeats, snp:promoter:multiple (human)		 RGD PMID:17003340 PMID:8150024 PMID:21067572 PMID:16701918 PMID:19587357 RGD:1626080, RGD:8548684, RGD:8548676, RGD:8548668, RGD:8548640 NCBI chr 4:63,899,222...63,913,315
Ensembl chr 4:62,932,031...62,946,157 		JBrowse link
G Akt1 AKT serine/threonine kinase 1 IEP mRNA, protein:increased expression:retina RGD PMID:31759996 RGD:41410819 NCBI chr 6:137,534,810...137,555,131
Ensembl chr 6:131,713,720...131,733,921 		JBrowse link
G Ang angiogenin ISO associated with Diabetes Mellitus, Type 2;protein:decreased tyrosine phosphorylation:vitreous humor RGD PMID:18978347 RGD:2307061 NCBI chr15:26,786,233...26,796,883 JBrowse link
G Angpt1 angiopoietin 1 ISO associated with Diabetes Mellitus, Experimental RGD PMID:12000720 RGD:2313818 NCBI chr 7:75,415,959...75,668,696
Ensembl chr 7:73,531,486...73,784,067 		JBrowse link
G Angpt2 angiopoietin 2 IEP
IDA		 protein:increased expression:retina (rat) RGD PMID:16520919 PMID:16520919 RGD:2314216, RGD:2314216 NCBI chr16:77,790,760...77,841,241
Ensembl chr16:71,088,364...71,138,804 		JBrowse link
G Aoc3 amine oxidase, copper containing 3 ISO associated with Diabetes Mellitus, Non-Insulin-Dependent;protein:increased expression:plasma RGD PMID:11522499 RGD:2313826 NCBI chr10:86,773,018...86,780,961 JBrowse link
G Apoa4 apolipoprotein A4 ISO protein:increased expression:vitreous humor (human) RGD PMID:19081814 RGD:5685692 NCBI chr 8:55,435,779...55,438,160
Ensembl chr 8:46,539,082...46,541,469 		JBrowse link
G Apob apolipoprotein B ISO associated with Diabetes Mellitus, Non-Insulin-Dependent RGD PMID:19448981 RGD:2313976 NCBI chr 6:36,563,704...36,603,300
Ensembl chr 6:30,844,368...30,892,497 		JBrowse link
G Apoc3 apolipoprotein C3 severity ISO protein:increased expression:serum RGD PMID:15642486 RGD:2306768 NCBI chr 8:55,428,172...55,430,352
Ensembl chr 8:46,531,478...46,533,583 		JBrowse link
G Apoe apolipoprotein E susceptibility
no_association		 ISO associated with Diabetic Mellitus type 2;DNA:polymorphism:exon: RGD PMID:16862278 PMID:11495633 RGD:7771557, RGD:7771553 NCBI chr 1:88,481,889...88,485,816
Ensembl chr 1:79,353,916...79,357,932 		JBrowse link
G Apoh apolipoprotein H ISO protein:increased expression:vitreous humor RGD PMID:18695102 RGD:2313982 NCBI chr10:93,841,992...93,855,897
Ensembl chr10:93,310,977...93,356,329 		JBrowse link
G Aqp4 aquaporin 4 IMP RGD PMID:22449442 RGD:8695996 NCBI chr18:6,782,389...6,799,034
Ensembl chr18:6,507,903...6,524,856 		JBrowse link
G Atg7 autophagy related 7 IEP
ISO		 associated with type 2 diabetes mellitus; protein:decreased, altered expression:retina
associated with type 1 diabetes mellitus;protein:decreased, altered expression:retina		 RGD PMID:32272782 PMID:32272782 RGD:407571700, RGD:407571700 NCBI chr 4:149,390,000...149,597,534
Ensembl chr 4:147,718,752...147,925,593 		JBrowse link
G Bdkrb1 bradykinin receptor B1 treatment IEP associated with Diabetes Mellitus, Experimental RGD PMID:18311190 RGD:2313334 NCBI chr 6:130,275,631...130,284,968
Ensembl chr 6:124,510,870...124,513,747 		JBrowse link
G Bdnf brain-derived neurotrophic factor IEP associated with Diabetes Mellitus, Experimental;protein:decreased expression:retina: RGD PMID:15331553 RGD:8655657 NCBI chr 3:116,619,633...116,670,212
Ensembl chr 3:96,165,042...96,215,615 		JBrowse link
G Becn1 beclin 1 IEP
ISO		 associated with type 2 diabetes mellitus; protein:decreased, altered expression:retina
associated with type 1 diabetes mellitus;protein:decreased, altered expression:retina		 RGD PMID:32272782 PMID:32272782 RGD:407571700, RGD:407571700 NCBI chr10:86,731,649...86,747,002
Ensembl chr10:86,231,388...86,246,742 		JBrowse link
G Casp3 caspase 3 IEP
ISO		 associated with Diabetes Mellitus, Experimental;protein:increased expresssion:retina
CTD Direct Evidence: marker/mechanism
associated with Diabetes Mellitus, Non-Insulin-Dependent		 CTD
RGD		 PMID:20654064 PMID:19187597 PMID:19013511 RGD:2311444, RGD:2311448 NCBI chr16:52,395,539...52,413,794
Ensembl chr16:45,662,910...45,684,648 		JBrowse link
G Casp9 caspase 9 ISO associated with Diabetes Mellitus, Non-Insulin-Dependent;protein:increased activation:retina RGD PMID:18369072 RGD:2311244 Ensembl chr 5:154,109,046...154,126,626 JBrowse link
G Cat catalase IEP protein:decreased expression:retina RGD PMID:21314438 RGD:5130875 NCBI chr 3:110,297,340...110,329,526
Ensembl chr 3:89,842,399...89,874,478 		JBrowse link
G Ccl2 C-C motif chemokine ligand 2 IEP associated with Diabetes Mellitus, Experimental;mRNA, protein:increased expression:retina (rat) RGD PMID:23010641 RGD:8548887 NCBI chr10:67,503,077...67,504,875
Ensembl chr10:67,005,424...67,007,226 		JBrowse link
G Ccl5 C-C motif chemokine ligand 5 severity ISO protein:increased expression:serum
associated with Diabetes Mellitus, Non-Insulin-Dependent;protein:decreased tyrosine phosphorylation:vitreous humor		 RGD PMID:16249511 PMID:18978347 RGD:2307104, RGD:2307061 NCBI chr10:68,820,330...68,824,906
Ensembl chr10:68,322,829...68,327,377 		JBrowse link
G Ccn2 cellular communication network factor 2 IEP associated with Diabetes Mellitus, Experimental; mRNA:increased expression:retina (rat) RGD PMID:19450451 RGD:2314507 NCBI chr 1:22,621,498...22,624,614
Ensembl chr 1:20,802,199...20,805,734 		JBrowse link
G Ccr5 C-C motif chemokine receptor 5 ISO associated with Diabetes Mellitus, Experimental RGD PMID:22677420 RGD:8551828 NCBI chr 8:132,629,097...132,660,980
Ensembl chr 8:123,752,325...123,759,260 		JBrowse link
G Cd34 CD34 molecule IEP mRNA, protein:increased expression:retina RGD PMID:31759996 RGD:41410819 NCBI chr13:109,008,786...109,029,317
Ensembl chr13:106,480,043...106,499,832 		JBrowse link
G Cd59b CD59b molecule IEP protein:decreased expression:retina RGD PMID:12453906 RGD:1600487 NCBI chr 3:110,914,008...110,932,489
Ensembl chr 3:90,459,162...90,478,847 		JBrowse link
G Cdkal1 CDK5 regulatory subunit associated protein 1-like 1 disease_progression ISO DNA:SNP:intron: (rs7756992) (human) RGD PMID:28821857 RGD:401850599 NCBI chr17:34,927,221...35,479,827
Ensembl chr17:34,718,687...35,407,524 		JBrowse link
G Cfb complement factor B no_association ISO associated with Diabetes Mellitus, Type 2;DNA:SNP: :rs1048709 (human)
associated with Diabetes Mellitus, Type 2;DNA:SNP: :rs537160, rs4151657, rs2072633 (human)		 RGD PMID:23864767 PMID:23864767 RGD:7365019, RGD:7365019 NCBI chr20:3,975,271...3,981,138
Ensembl chr20:3,951,474...3,976,505 		JBrowse link
G Cfh complement factor H ISO associated with Diabetes Mellitus, Type 2; DNA:SNP: :rs800292(human)
associated with Diabetes Mellitus, Type 1;DNA:SNP: :rs1410996(human) 		RGD PMID:23864767 PMID:23296223 RGD:7365019, RGD:7365023 NCBI chr13:54,063,079...54,164,523
Ensembl chr13:51,511,828...51,613,838 		JBrowse link
G Cldn1 claudin 1 treatment IEP RGD PMID:25685822 RGD:11341734 NCBI chr11:87,926,376...87,941,533
Ensembl chr11:74,421,569...74,436,724 		JBrowse link
G Clu clusterin treatment ISO associated with Diabetes Mellitus, Experimental RGD PMID:19875648 RGD:9068395 NCBI chr15:44,336,619...44,375,861
Ensembl chr15:40,174,617...40,200,315 		JBrowse link
G Crp C-reactive protein ISO protein:increased expression:serum:
CTD Direct Evidence: marker/mechanism		 CTD
RGD		 PMID:20012460 PMID:20012460 RGD:8547537 NCBI chr13:87,694,062...87,695,978
Ensembl chr13:85,124,977...85,175,178 		JBrowse link
G Cxcl10 C-X-C motif chemokine ligand 10 ISO RGD PMID:17194635 RGD:2311361 NCBI chr14:15,989,066...15,991,263
Ensembl chr14:15,704,758...15,706,975 		JBrowse link
G Cxcl12 C-X-C motif chemokine ligand 12 severity ISO protein:increased expression:vitreous humor RGD PMID:15630447 RGD:2306559 NCBI chr 4:152,060,781...152,073,628
Ensembl chr 4:150,388,325...150,401,168 		JBrowse link
G Cyba cytochrome b-245 alpha chain IEP associated with Diabetes Mellitus, Experimental RGD PMID:19685553 RGD:2317854 NCBI chr19:67,396,143...67,404,214
Ensembl chr19:50,487,597...50,495,721 		JBrowse link
G Dll4 delta like canonical Notch ligand 4 severity ISO mRNA,protein:increased expression:retina: RGD PMID:30787185 PMID:34362349 RGD:155663348, RGD:155663356 NCBI chr 3:126,770,945...126,780,769
Ensembl chr 3:106,316,986...106,326,931 		JBrowse link
G Edn1 endothelin 1 ISO
IEP		 associated with Diabetes Mellitus, Non-Insulin-Dependent;DNA:polymorphism:exon:p.K198N (human)
mRNA:increased expression:retina (rat)
associated with Diabetes Mellitus, Insulin-Dependent;protein:increased secretion:plasma		 RGD PMID:18806884 PMID:20628425 PMID:19293263 RGD:2313281, RGD:9068929, RGD:2313279 NCBI chr17:22,660,799...22,666,687
Ensembl chr17:22,454,420...22,460,885 		JBrowse link
G Egfr epidermal growth factor receptor treatment ISO protein:increased expression:retina
associated with Diabetes Mellitus, Experimental		 RGD PMID:7947554 PMID:23831329 RGD:1580957, RGD:10059675 NCBI chr14:95,378,626...95,551,358
Ensembl chr14:91,177,067...91,344,382 		JBrowse link
G Eln elastin ISO RGD PMID:11707314 RGD:9585734 NCBI chr12:27,604,983...27,648,413
Ensembl chr12:21,968,544...22,011,928 		JBrowse link
G Eng endoglin ISO associated with Diabetes Mellitus, Insulin-Dependent; protein:increased expression:plasma,vitreous body RGD PMID:16202216 RGD:1580961 NCBI chr 3:36,332,190...36,370,324
Ensembl chr 3:15,934,518...15,973,230 		JBrowse link
G Ep300 E1A binding protein p300 IMP associated with Diabetes Mellitus, Experimental RGD PMID:21885871 RGD:7349382 NCBI chr 7:114,987,857...115,058,652
Ensembl chr 7:113,106,247...113,136,088
Ensembl chr 7:113,106,247...113,136,088 		JBrowse link
G Epo erythropoietin susceptibility ISO protein:increased expression:serum,vitreous body
associated with Diabetes Mellitus, Experimental
DNA:snp:promoter:-1125T>G(rs1617640)(human)		 RGD PMID:18670462 PMID:24508793 PMID:18235022 PMID:18458324 RGD:2313837, RGD:10400906, RGD:2313890, RGD:2313838 NCBI chr12:24,841,285...24,844,725
Ensembl chr12:19,204,508...19,207,946 		JBrowse link
G F13a1 coagulation factor XIII A1 chain ISO protein:increased expression:optic choroid vascular plexus: RGD PMID:11375345 RGD:8693344 NCBI chr17:28,021,197...28,197,960
Ensembl chr17:27,815,702...27,992,700 		JBrowse link
G F3 coagulation factor III, tissue factor ISO protein:increased expression:aqueous humor,serum RGD PMID:12417540 RGD:2313865 NCBI chr 2:212,511,675...212,523,375
Ensembl chr 2:209,826,959...209,838,668 		JBrowse link
G F7 coagulation factor VII ISO associated with Diabetes Mellitus, Insulin-Dependent; protein:increased activity:plasma (human) RGD PMID:10837382 RGD:2312398 NCBI chr16:83,191,896...83,202,775
Ensembl chr16:76,489,717...76,500,610 		JBrowse link
G Fgf2 fibroblast growth factor 2 ISO
IEP		 associated with Pregnancy in Diabetics
DNA:polymorphism:intron:g.754C>G(human)
DNA:polymorphism:promotor:g.-553T>A(human)
associated with Diabetes Mellitus, Experimental		 RGD PMID:9141532 PMID:17997184 PMID:18279437 PMID:14975211 RGD:2315885, RGD:2315845, RGD:2315844, RGD:2315875 NCBI chr 2:122,164,454...122,218,796
Ensembl chr 2:120,236,328...120,291,221 		JBrowse link
G Flt1 Fms related receptor tyrosine kinase 1 treatment ISO
IEP		 RGD PMID:17143550 PMID:18174522 RGD:2313721, RGD:10402119 NCBI chr12:12,333,050...12,504,750
Ensembl chr12:7,297,292...7,468,626 		JBrowse link
G Fuca1 alpha-L-fucosidase 1 IEP associated with Diabetes Mellitus, Experimental;protein:increased activity:retina RGD PMID:10353622 RGD:2315932 NCBI chr 5:153,436,262...153,453,512
Ensembl chr 5:148,152,700...148,169,972 		JBrowse link
G Gad2 glutamate decarboxylase 2 ISO CTD Direct Evidence: marker/mechanism CTD PMID:21412422 NCBI chr17:89,671,718...89,734,246
Ensembl chr17:84,763,628...84,826,155 		JBrowse link
G Gapdh glyceraldehyde-3-phosphate dehydrogenase IEP associated with Diabetes Mellitus, Experimental RGD PMID:18852331 RGD:2315975 NCBI chr 4:159,648,592...159,653,436
Ensembl chr 4:157,962,343...157,966,235 		JBrowse link
G Gc GC, vitamin D binding protein ISO protein:increased expression:vitreous body RGD PMID:16080911 RGD:2315548 NCBI chr14:18,916,255...18,951,670
Ensembl chr14:18,632,135...18,667,567 		JBrowse link
G Ggt1 gamma-glutamyltransferase 1 ISO associated with Diabetes Mellitus,Insulin-Dependent;protein:increased activity:serum RGD PMID:11311965 RGD:2315614 NCBI chr20:13,074,141...13,103,551
Ensembl chr20:13,074,700...13,108,442 		JBrowse link
G Gh1 growth hormone 1 ISO RGD PMID:3183302 RGD:2315688 NCBI chr10:91,727,883...91,729,860
Ensembl chr10:91,228,103...91,230,078 		JBrowse link
G Glo1 glyoxalase 1 no_association ISO DNA:SNP:promoter:-7C>T (human) RGD PMID:21738003 PMID:21738003 RGD:7242569, RGD:7242569 NCBI chr20:8,665,061...8,683,095
Ensembl chr20:8,662,801...8,681,649 		JBrowse link
G Glul glutamate-ammonia ligase treatment IEP associated with Experimental Diabetes Mellitus RGD PMID:34133251 RGD:401794594 NCBI chr13:68,519,500...68,585,554
Ensembl chr13:66,025,630...66,035,108 		JBrowse link
G Gstm1 glutathione S-transferase mu 1 susceptibility ISO associated with Diabetes Mellitus, Type 1;DNA:deletion:cds (human) RGD PMID:19752172 RGD:7495818 NCBI chr 2:198,338,005...198,346,007
Ensembl chr 2:195,649,845...195,655,411 		JBrowse link
G Gstt1 glutathione S-transferase theta 1 disease_progression
no_association		 ISO associated with Diabetes Mellitus, Type 2;DNA:deletion:cds (human)
associated with Diabetes Mellitus, Type 1;DNA:deletion:cds (human)		 RGD PMID:15927971 PMID:19752172 RGD:2306630, RGD:7495818 NCBI chr20:12,856,068...12,873,020
Ensembl chr20:12,856,669...12,873,585 		JBrowse link
G Hes1 hes family bHLH transcription factor 1 ISO mRNA:increased expression:retina: RGD PMID:30787185 RGD:155663348 NCBI chr11:84,210,632...84,213,045
Ensembl chr11:70,705,764...70,708,192 		JBrowse link
G Hey2 hes-related family bHLH transcription factor with YRPW motif 2 ISO mRNA:increased expression:retina: RGD PMID:30787185 RGD:155663348 NCBI chr 1:28,641,100...28,651,187
Ensembl chr 1:26,822,131...26,832,218 		JBrowse link
G Hfe homeostatic iron regulator ISO associated with Diabetes Mellitus, Type 2;DNA:missense mutation:cds:p.C282Y (human) RGD PMID:15347835 RGD:8694362 NCBI chr17:41,841,302...41,849,359
Ensembl chr17:41,413,451...41,421,502 		JBrowse link
G Hgf hepatocyte growth factor disease_progression ISO associated with Diabetes Mellitus, Insulin-Dependent;protein:increased expression:serum RGD PMID:18335393 PMID:15525877 RGD:2313565, RGD:8548539 NCBI chr 4:19,628,902...19,700,467
Ensembl chr 4:18,677,101...18,745,409 		JBrowse link
G Hif1a hypoxia inducible factor 1 subunit alpha severity
treatment		 ISO
IDA
IEP		 protein:increased expression:retina, vascular endothelial cell (human)
associated with Diabetes Mellitus, Experimental
associated with Diabetes Mellitus, Experimental;protein:increased expression:retina (rat)		 RGD PMID:17229797 PMID:20515763 PMID:22110070 RGD:8694462, RGD:8696025, RGD:7364887 NCBI chr 6:98,357,788...98,405,068
Ensembl chr 6:92,624,390...92,669,261 		JBrowse link
G Hras HRas proto-oncogene, GTPase IDA RGD PMID:14988264 RGD:1358731 NCBI chr 1:205,712,625...205,729,406
Ensembl chr 1:196,296,263...196,300,615 		JBrowse link
G Icam1 intercellular adhesion molecule 1 treatment ISO
IEP		 CTD Direct Evidence: therapeutic
associated with Diabetes Mellitus, Non-Insulin-Dependent;DNA:polymorphism: :p.K469E (human)		 CTD
RGD		 PMID:10485912 PMID:18834676 PMID:25066112 PMID:18942221 RGD:2313472, RGD:11354984, RGD:2313471 NCBI chr 8:27,829,688...27,841,618
Ensembl chr 8:19,553,645...19,565,438 		JBrowse link
G Igf1 insulin-like growth factor 1 susceptibility ISO protein:decreased expression:serum RGD PMID:16873705 PMID:17194636 RGD:1598424, RGD:2313764 NCBI chr 7:24,169,608...24,249,446
Ensembl chr 7:22,282,930...22,359,296 		JBrowse link
G Igf1r insulin-like growth factor 1 receptor disease_progression IEP mRNA:increased expression:retina: RGD PMID:12781065 RGD:10046008 NCBI chr 1:130,959,787...131,248,664
Ensembl chr 1:121,550,743...121,831,777 		JBrowse link
G Il10 interleukin 10 susceptibility ISO associated with Diabetes Mellitus, Non-Insulin-Dependent;protein:decreased tyrosine phosphorylation:vitreous humor
associated with Diabetes Mellitus, Type 2		 RGD PMID:18978347 PMID:22105495 PMID:18988929 PMID:16696964 RGD:2307061, RGD:7364856, RGD:2307272, RGD:1598486 NCBI chr13:45,024,921...45,029,586
Ensembl chr13:42,472,839...42,477,313 		JBrowse link
G Il18 interleukin 18 ISO associated with Diabetes Mellitus, Type 2;protein:increased expression:serum RGD PMID:19011009 PMID:16260350 RGD:4889417, RGD:8655907 NCBI chr 8:59,802,072...59,829,275
Ensembl chr 8:50,906,960...50,932,887 		JBrowse link
G Il1a interleukin 1 alpha ISO associated with Diabetes Mellitus, Non-Insulin-Dependent;protein:decreased tyrosine phosphorylation:vitreous humor RGD PMID:18978347 RGD:2307061 NCBI chr 3:136,979,804...136,990,236
Ensembl chr 3:116,526,604...116,536,822 		JBrowse link
G Il1b interleukin 1 beta ISO associated with Diabetes Mellitus, Type 2; protein:decreased tyrosine phosphorylation:vitreous humor
protein:increased expression:serum, vitreous humour		 RGD PMID:18978347 PMID:16284605 RGD:2307061, RGD:7401212 NCBI chr 3:137,030,200...137,036,581
Ensembl chr 3:116,577,010...116,583,415 		JBrowse link
G Il6 interleukin 6 susceptibility ISO associated with Diabetes Mellitus; DNA:polymorphism:promoter:-174G>C (human)
associated with Diabetes Mellitus, Type1;DNA:polymorphism:promoter:-174G>C(human)
associated with Diabetes Mellitus, Typpe 1;protein:increased expression:serum:
associated with Diabetes Mellitus, Non-Insulin-Dependent; protein:increased expression:extracellular space (human)		 RGD PMID:19140096 PMID:19542902 PMID:17725274 PMID:18988929 RGD:2307267, RGD:7829816, RGD:7829749, RGD:2307272 NCBI chr 4:5,889,999...5,894,575
Ensembl chr 4:5,213,394...5,219,178 		JBrowse link
G Ins2 insulin 2 ISO CTD Direct Evidence: marker/mechanism CTD
RGD		 PMID:30463601 PMID:22046295 RGD:6902909 NCBI chr 1:207,272,738...207,421,998
Ensembl chr 1:197,843,281...197,864,775 		JBrowse link
G Insr insulin receptor ISS MouseDO NCBI chr12:5,991,135...6,129,275
Ensembl chr12:1,197,100...1,330,883 		JBrowse link
G Itga2 integrin subunit alpha 2 severity
no_association
susceptibility		 ISO associated with Diabetes Mellitus; DNA:transition:cds:807C>T (human)
associated with Diabetes Mellitus, Type 2;DNA:snp:cds:c.807T>C (human)
associated with Diabetes Mellitus, Type 2;DNA:snp:intron:IVS8-1059T>C (human)
associated with Diabetes Mellitus, Type 2;DNA:snp:intron:IVS7+3160A>G (human)		 RGD PMID:12540964 PMID:21632096 PMID:18806884 PMID:23776381 RGD:2307419, RGD:8686431, RGD:2313281, RGD:7777103 NCBI chr 2:48,253,412...48,354,509
Ensembl chr 2:46,523,948...46,621,481 		JBrowse link
G Itga4 integrin subunit alpha 4 treatment IMP associated with Diabetes Mellitus, Experimental RGD PMID:19553613 RGD:9698417 NCBI chr 3:84,569,487...84,646,276
Ensembl chr 3:64,163,085...64,233,715 		JBrowse link
G Itgam integrin subunit alpha M IEP mRNA, protein:increased expression:retina (rat) RGD PMID:33614447 RGD:329901937 NCBI chr 1:192,089,496...192,139,947
Ensembl chr 1:182,659,000...182,709,503 		JBrowse link
G Itgb3 integrin subunit beta 3 ISO protein:increased expression:optic choroid vascular plexus: RGD PMID:11375345 RGD:8693344 NCBI chr10:90,009,927...90,067,787
Ensembl chr10:89,509,989...89,564,679 		JBrowse link
G Jag1 jagged canonical Notch ligand 1 ISO mRNA,protein:increased expression:retina: RGD PMID:30787185 RGD:155663348 NCBI chr 3:144,859,453...144,894,883
Ensembl chr 3:124,406,794...124,442,209 		JBrowse link
G Kcnj10 potassium inwardly-rectifying channel, subfamily J, member 10 treatment IDA
IEP		 associated with Diabetes Mellitus, Experimental RGD PMID:21672350 PMID:22143324 RGD:8662869, RGD:8662907 NCBI chr13:87,334,510...87,367,747
Ensembl chr13:84,802,009...84,835,461 		JBrowse link
G Kdm1a lysine demethylase 1A IEP
ISO		 mRNA, protein:increased expression:retina (rat)
mRNA:increased expression:retina (human)		 RGD PMID:23423566 PMID:23423566 PMID:23423566 RGD:8547881, RGD:8547881, RGD:8547881 NCBI chr 5:154,066,436...154,121,913
Ensembl chr 5:148,782,976...148,838,319 		JBrowse link
G Keap1 Kelch-like ECH-associated protein 1 IEP associated with Diabetes Mellitus, Experimental;mRNA, protein:increased expression:retina RGD PMID:23633659 RGD:10412733 NCBI chr 8:28,044,555...28,054,042
Ensembl chr 8:19,768,375...19,777,862 		JBrowse link
G Lta lymphotoxin alpha no_association
susceptibility		 ISO associated with Diabetes Mellitus, Type 2;DNA:polymorphism:intron, exon:252A>G, 804C>A (human) RGD PMID:16979413 PMID:11399938 RGD:8548772, RGD:8548797 NCBI chr20:3,622,291...3,625,852
Ensembl chr20:3,618,853...3,620,859 		JBrowse link
G Mesp1 mesoderm posterior bHLH transcription factor 1 ISO associated with type 2 diabetes mellitus;DNA:increased expression:plasma (human) RGD PMID:33221518 RGD:242905212 NCBI chr 1:143,147,671...143,149,189
Ensembl chr 1:133,738,357...133,739,875 		JBrowse link
G Mfn2 mitofusin 2 IEP associated with Diabetes Mellitus, Experimental;mRNA, protein:decreased expression:retina (rat) RGD PMID:28487236 RGD:12910715 NCBI chr 5:163,587,463...163,617,363
Ensembl chr 5:158,304,287...158,335,342 		JBrowse link
G Mir126b microRNA 126b ameliorates IEP
IDA		 RNA:decreased expression:serum,retina RGD PMID:33416109 PMID:33416109 RGD:401850543, RGD:401850543 NCBI chr 3:29,813,174...29,813,246 JBrowse link
G Mir17 microRNA 17 treatment ISO RGD PMID:33333415 RGD:329349303 NCBI chr15:98,587,848...98,587,931
Ensembl chr15:92,180,629...92,180,712 		JBrowse link
G Mir21 microRNA 21 IEP RNA:increased expression:retina RGD PMID:31759996 RGD:41410819 NCBI chr10:71,902,600...71,902,691
Ensembl chr10:71,405,257...71,405,348 		JBrowse link
G Mir320a microRNA 320a ISO miRNA:decreased expression:blood plasma (human) RGD PMID:32178730 RGD:155882566 NCBI chr15:51,926,088...51,926,169
Ensembl chr15:45,516,392...45,516,473 		JBrowse link
G Mmp2 matrix metallopeptidase 2 ISO protein:increased expression:plasma RGD PMID:12714657 PMID:18552985 RGD:1582582, RGD:8547849 NCBI chr19:30,327,643...30,355,856
Ensembl chr19:14,154,657...14,182,870 		JBrowse link
G Mmp9 matrix metallopeptidase 9 disease_progression ISO associated with Diabetes Mellitus, Experimental
associated with Diabetes Mellitus, Type 2		 RGD PMID:16643893 PMID:21933988 PMID:10374894 RGD:1582616, RGD:8547857, RGD:8547815 NCBI chr 3:174,103,474...174,111,434
Ensembl chr 3:153,683,858...153,692,120 		JBrowse link
G Mthfr methylenetetrahydrofolate reductase susceptibility ISO associated with Diabetes Mellitus, Type 2; DNA:transition:cds:g.677C>T (human) RGD PMID:9040583 RGD:6893525 NCBI chr 5:163,748,346...163,768,141
Ensembl chr 5:158,465,296...158,483,797 		JBrowse link
G Mysm1 myb-like, SWIRM and MPN domains 1 susceptibility ISO associated with Diabetes Mellitus, Type 2;DNA:snps:introns: IVS1-1269C>T, IVS6+1700G>A (rs2811893, rs12092121) (human) RGD PMID:21310492 RGD:9589162 NCBI chr 5:114,877,112...114,981,463
Ensembl chr 5:109,776,286...109,819,967 		JBrowse link
G Nfe2l2 NFE2 like bZIP transcription factor 2 IDA associated with Diabetes Mellitus, Experimental;protein:decreased activity:retina RGD PMID:23633659 RGD:10412733 NCBI chr 3:81,001,529...81,031,165
Ensembl chr 3:60,594,242...60,621,737 		JBrowse link
G Ngf nerve growth factor ISO
IMP		 protein:increased expression:serum
associated with Experimental Diabetes Mellitus		 RGD PMID:18282491 PMID:24030532 RGD:7242804, RGD:405100241 NCBI chr 2:192,589,580...192,642,971
Ensembl chr 2:189,901,058...189,954,452 		JBrowse link
G Nos1 nitric oxide synthase 1 IEP mRNA, protein:decreased expression:retina RGD PMID:17545029 RGD:1642141 NCBI chr12:44,276,011...44,456,371
Ensembl chr12:38,626,714...38,710,945 		JBrowse link
G Nos3 nitric oxide synthase 3 no_association
susceptibility
treatment
severity
onset		 ISO
IDA
IEP		 associated with Diabetes Mellitus, Type 2;DNA:duplication:intron:IVS4?-?+27 (human)
associated with Diabetes Mellitus, Type 2;DNA:snp:exon:c.894G>T (human)
associated with Diabetes Mellitus, Type 2;DNA:snps, duplication, haplotype:promoter, cds, intron:g.-786T>C, p.E298N, IVS4?-?+27 (human)
associated with Diabetes Mellitus, Experimental
associated with Diabetes Mellitus, Experimental;mRNA:decreased expression:retina (rat)
DNA:snps:promoter, exon:c.-786T>C, c.774C>T (human)
associated with Diabetes Mellitus, Type 1;DNA:duplication:intron:IVS4?-?+27 (human)		 RGD PMID:16581274 PMID:23776381 PMID:22017289 PMID:17558849 PMID:18840783 More... RGD:7421531, RGD:7777103, RGD:7777101, RGD:7775042, RGD:7771606, RGD:7771569, RGD:7771568, RGD:7771565, RGD:7421533, RGD:7421532 NCBI chr 4:11,686,088...11,706,604
Ensembl chr 4:10,793,834...10,814,166 		JBrowse link
G Notch1 notch receptor 1 treatment ISO RGD PMID:30787185 RGD:155663348 NCBI chr 3:29,676,040...29,721,613
Ensembl chr 3:9,278,086...9,323,531 		JBrowse link
G Nppa natriuretic peptide A ISO protein:increased expression:vitreous humor RGD PMID:15273657 RGD:2313589 NCBI chr 5:163,712,184...163,713,493
Ensembl chr 5:158,429,042...158,430,351 		JBrowse link
G Npr3 natriuretic peptide receptor 3 IEP mRNA:decreased expression:retina (rat) RGD PMID:15789000 RGD:1580773 NCBI chr 2:62,592,557...62,660,497
Ensembl chr 2:60,870,594...60,932,955 		JBrowse link
G Nr3c1 nuclear receptor subfamily 3, group C, member 1 IEP associated with Experimental Diabetes Mellitus;protein:altered expression:retina RGD PMID:37904673 RGD:408364965 NCBI chr18:31,522,783...31,644,508
Ensembl chr18:31,271,681...31,393,375 		JBrowse link
G Nrp1 neuropilin 1 treatment ISO RGD PMID:26554379 RGD:401901170 NCBI chr19:73,256,557...73,411,705
Ensembl chr19:56,359,455...56,513,633 		JBrowse link
G Nutf2 nuclear transport factor 2 treatment ISO
IDA		 mRNA:decreased expression:peripheral blood: RGD PMID:19404486 PMID:19404486 RGD:9831377, RGD:9831377 NCBI chr19:50,662,168...50,683,457
Ensembl chr19:33,752,291...33,773,591 		JBrowse link
G Ocln occludin treatment IEP RGD PMID:25685822 RGD:11341734 NCBI chr 2:33,391,303...33,442,207
Ensembl chr 2:31,657,220...31,764,150 		JBrowse link
G Pf4 platelet factor 4 IEP protein:increased expression:retina RGD PMID:23352833 RGD:329901846 NCBI chr14:17,582,477...17,583,392
Ensembl chr14:17,298,308...17,299,365 		JBrowse link
G Pgf placental growth factor IEP associated with Diabetes Mellitus, Type 2 RGD PMID:21408222 RGD:6483775 NCBI chr 6:110,547,165...110,557,747
Ensembl chr 6:104,816,104...104,826,685 		JBrowse link
G Pik3cg phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit gamma IEP mRNA, protein:increased expression:retina RGD PMID:31759996 RGD:41410819 NCBI chr 6:54,494,247...54,529,563
Ensembl chr 6:48,766,864...48,802,043 		JBrowse link
G Plk4 polo-like kinase 4 treatment IEP RGD PMID:33416109 RGD:401850543 NCBI chr 2:125,730,480...125,748,894
Ensembl chr 2:123,802,512...123,820,942 		JBrowse link
G Pon1 paraoxonase 1 susceptibility ISO DNA:polymorphism:promoter:g.-907C>G (human)
CTD Direct Evidence: marker/mechanism
associated with Diabetes Mellitus;DNA:missense mutation:cds:p.L55M (rs854560) (human)
associated with Diabetes Mellitus, Type 2;DNA:missense mutation:cds:p.Q192R (human)
associated with Diabetes Mellitus, Type 1;protein:decreased activity:serum (human)		 CTD
RGD		 PMID:9661650 PMID:20012460 PMID:16949520 PMID:24100645 PMID:15270786 More... RGD:2313272, RGD:8547572, RGD:8547548, RGD:8547537 NCBI chr 4:34,261,312...34,292,327
Ensembl chr 4:33,294,722...33,321,360 		JBrowse link
G Pparg peroxisome proliferator-activated receptor gamma ISO Retinal Leukostasis;associated with Diabetes Mellitus, Experimental RGD PMID:17003451 RGD:8552824 NCBI chr 4:150,095,743...150,221,104
Ensembl chr 4:148,423,194...148,548,468 		JBrowse link
G Ppargc1a PPARG coactivator 1 alpha IDA
IEP		 associated with Diabetes Mellitus, Experimental; mRNA:increased expression:retina (rat) RGD PMID:20566666 PMID:22003111 RGD:6484532, RGD:5686899 NCBI chr14:63,073,505...63,729,215
Ensembl chr14:58,861,144...59,512,656 		JBrowse link
G Pten phosphatase and tensin homolog IEP mRNA, protein:decreased expression:retina RGD PMID:31759996 RGD:41410819 NCBI chr 1:240,043,707...240,110,330
Ensembl chr 1:230,630,338...230,696,838 		JBrowse link
G Rbp4 retinol binding protein 4 severity ISO protein:increased expression:blood plasma (human) RGD PMID:30135138 RGD:329849110 NCBI chr 1:245,306,349...245,313,551
Ensembl chr 1:235,893,917...235,901,399 		JBrowse link
G Retn resistin ISO associated with Diabetes Mellitus, Type 2 RGD PMID:17303077 RGD:7207162 NCBI chr12:6,508,653...6,511,115
Ensembl chr12:1,710,881...1,712,620 		JBrowse link
G Robo1 roundabout guidance receptor 1 IEP mRNA,protein:increased expression:retina RGD PMID:28973045 RGD:243048421 NCBI chr11:24,067,869...25,108,694
Ensembl chr11:10,580,908...11,620,203 		JBrowse link
G RT1-Bb RT1 class II, locus Bb susceptibility
severity		 ISO associated with Diabetes Mellitus, Type 1;DNA:polymorphisms, haplotypes:cds:HLA-DQB1*0201, HLA-DQB1*0501, HLA-DQB1*0504 (human)
DNA:polymorphisms, haplotype:cds:HLA-DQB1*0201, HLA-DQB1*0302 (human)		 RGD PMID:19551681 PMID:8932997 RGD:7421552, RGD:7483573 NCBI chr20:4,598,475...4,604,118
Ensembl chr20:4,596,559...4,607,597 		JBrowse link
G RT1-CE13 RT1 class I, locus CE13 susceptibility ISO associated with Diabetes Mellitus, Type 1; DNA:polymorphisms:cds:HLA-B*49 (human) RGD PMID:22981956 RGD:7365095 NCBI chr20:3,314,491...3,322,815 JBrowse link
G RT1-Db1 RT1 class II, locus Db1 susceptibility ISO associated with Diabetes Mellitus Type 1;DNA:polymorphism::DRB1*0301,DRB1*0402(human) RGD PMID:23837223 RGD:7365113 NCBI chr20:4,550,594...4,560,182
Ensembl chr20:4,548,666...4,558,258 		JBrowse link
G Serpina4 serpin family A member 4 ISO protein:decreased expression:vitreous fluid (human) RGD PMID:8950506 RGD:1580289 NCBI chr 6:128,764,738...128,773,858
Ensembl chr 6:122,999,900...123,009,082 		JBrowse link
G Serpine1 serpin family E member 1 susceptibility
no_association		 ISO associated with Diabetes Mellitus, Type 2;DNA:deletion:promoter:g.-676_-674delG (human)
associated with Diabetes Mellitus, Type 2;DNA:snp, deletion:promoter:g.-844G>A, g.-676_-674delG (human)
associated with Diabetes Mellitus;repeat, snp:intron, 3' utr:g.7844(CA)1-6, ? (human)
associated with Diabetes Mellitus, Type 1;protein:increased expression:plasma (human)		 RGD PMID:23281898 PMID:19419896 PMID:7974340 PMID:9201602 PMID:12660488 RGD:8547697, RGD:8547741, RGD:8547740, RGD:8547710, RGD:8547699 NCBI chr12:25,237,977...25,248,356
Ensembl chr12:19,601,272...19,611,657 		JBrowse link
G Serpinf1 serpin family F member 1 severity ISO
IEP		 associated with Diabetes Mellitus, Non-Insulin-Dependent;DNA:SNPs:promoter:g.-5740T>C, g.-5308G>A (rs12150053, rs12948385) (human)
protein:increased expression:vitreous humor
associated with Diabetes Mellitus, Non-Insulin-Dependent;protein:increased expression:vitreous humor
associated with Diabetes Mellitus, Non-Insulin-Dependent;protein:increased expression:retina
associated with Diabetes Mellitus, Insulin-Dependent;protein:increased expression:serum
protein:alternative form:vitreous humor		 RGD PMID:17658465 PMID:15059706 PMID:18025835 PMID:16054135 PMID:18455830 More... RGD:2312346, RGD:1580135, RGD:2312344, RGD:2312348, RGD:2312341, RGD:2312337 NCBI chr10:60,748,504...60,760,898
Ensembl chr10:60,249,708...60,262,646 		JBrowse link
G Sgf29 SAGA complex associated factor 29 severity ISO associated with Diabetes Mellitus, Type 1; DNA:SNP:intron: rs10521145(human) RGD PMID:21441570 RGD:9587455 NCBI chr 1:190,668,803...190,702,500
Ensembl chr 1:181,238,468...181,274,781 		JBrowse link
G Sirt1 sirtuin 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:24894401 NCBI chr20:25,305,953...25,328,000
Ensembl chr20:25,306,917...25,329,260 		JBrowse link
G Slit2 slit guidance ligand 2 IEP mRNA,protein:increased expression:retina RGD PMID:28973045 RGD:243048421 NCBI chr14:66,829,661...67,168,517
Ensembl chr14:62,617,067...62,955,948 		JBrowse link
G Sod1 superoxide dismutase 1 ISO human gene in a mouse model
CTD Direct Evidence: therapeutic		 CTD
RGD		 PMID:19074809 PMID:19074809 RGD:8655572 NCBI chr11:42,942,742...42,948,399
Ensembl chr11:29,456,558...29,462,249 		JBrowse link
G Sod3 superoxide dismutase 3 ISO RGD PMID:12663605 RGD:1581298 NCBI chr14:62,822,865...62,828,602
Ensembl chr14:58,609,958...58,615,990 		JBrowse link
G Stra6 signaling receptor and transporter of retinol STRA6 treatment ISO associated with type 2 diabetes mellitus RGD PMID:30096827 RGD:155631301 NCBI chr 8:67,444,757...67,464,719
Ensembl chr 8:58,549,736...58,568,860 		JBrowse link
G Tgfbr2 transforming growth factor, beta receptor 2 ISO ClinVar Annotator: match by term: Diabetic retinopathy ClinVar PMID:9536098 PMID:15731757 PMID:16799921 PMID:17576681 PMID:21270064 More... NCBI chr 8:124,672,677...124,761,741
Ensembl chr 8:115,794,537...115,883,228 		JBrowse link
G Thbs1 thrombospondin 1 IEP
ISO		 associated with Diabetes Mellitus, Experimental
CTD Direct Evidence: marker/mechanism		 CTD
RGD		 PMID:17117553 PMID:17117553 RGD:2317943 NCBI chr 3:125,510,250...125,525,402
Ensembl chr 3:105,056,292...105,071,440 		JBrowse link
G Timm44 translocase of inner mitochondrial membrane 44 IEP associated with Diabetes Mellitus, Experimental;mRNA:decreased expression:retina RGD PMID:22003103 RGD:13463597 NCBI chr12:7,410,424...7,428,179
Ensembl chr12:2,612,581...2,629,351 		JBrowse link
G Tlr4 toll-like receptor 4 onset ISO associated with Diabetes Mellitus, Non-Insulin-Dependent;DNA:polymorphism: :p.N299G (human) RGD PMID:19135114 RGD:2312487 NCBI chr 5:85,161,247...85,174,882
Ensembl chr 5:80,145,826...80,159,628 		JBrowse link
G Tnf tumor necrosis factor no_association
disease_progression		 ISO associated with Diabetes Mellitus, Type 2
associated with Diabetes Mellitus, Type 2;DNA:polymorphism:promoter:-302A>G (human)
protein:increased expression:serum, vitreous humour
associated with Diabetes Mellitus, Type 1;protein:increased expression:platelet:		 RGD PMID:22105495 PMID:16979413 PMID:16284605 PMID:10540181 RGD:7364856, RGD:8548772, RGD:7401212, RGD:7394805 NCBI chr20:3,626,685...3,629,303
Ensembl chr20:3,622,011...3,624,629 		JBrowse link
G Uts2 urotensin 2 ISO associated with Diabetes Mellitus, Non-Insulin-Dependent;protein:increased expression:plasma RGD PMID:18338983 RGD:2306795 NCBI chr 5:166,725,471...166,739,063
Ensembl chr 5:161,450,846...161,456,237 		JBrowse link
G Vcam1 vascular cell adhesion molecule 1 ISO associated with Diabetes Mellitus, Non-Insulin-Dependent;protein:increased expression:vitreous humor, serum RGD PMID:19237221 RGD:2312762 NCBI chr 2:206,723,050...206,742,783
Ensembl chr 2:204,038,114...204,057,958 		JBrowse link
G Vdr vitamin D receptor ISO RGD PMID:15899948 RGD:1580363 NCBI chr 7:130,864,764...130,916,757
Ensembl chr 7:128,987,981...129,037,677 		JBrowse link
G Vegfa vascular endothelial growth factor A ISO
IEP		 mRNA, protein:increased expression:retina
CTD Direct Evidence: marker/mechanism
associated with Diabetes Mellitus, type 2; protein:increased expression:aqueous humor of eyeball:		 CTD
RGD		 PMID:11978667 PMID:15788408 PMID:20577866 PMID:17513698 PMID:31759996 More... RGD:2301992, RGD:41410819, RGD:8547996, RGD:1580565 NCBI chr 9:22,452,854...22,468,194
Ensembl chr 9:14,955,300...14,970,641 		JBrowse link
G Vps26a VPS26 retromer complex component A susceptibility ISO DNA:SNP:: (rs1802295) (Human) RGD PMID:28821857 RGD:401850599 NCBI chr20:30,947,018...30,976,964
Ensembl chr20:30,404,325...30,434,131 		JBrowse link
G Vtn vitronectin ISO
IEP		 associated with Diabetes Mellitus, Experimental RGD PMID:7536680 PMID:8804356 RGD:1580818, RGD:10040982 NCBI chr10:63,892,782...63,895,862
Ensembl chr10:63,394,719...63,397,810 		JBrowse link
G Vwf von Willebrand factor ISO RGD PMID:10077454 RGD:1580648 NCBI chr 4:160,042,900...160,177,757
Ensembl chr 4:158,360,152...158,491,539 		JBrowse link
G Wfs1 wolframin ER transmembrane glycoprotein susceptibility ISO DNA:SNP:: (rs10010131) (Human) RGD PMID:28821857 RGD:401850599 NCBI chr14:78,035,205...78,059,718
Ensembl chr14:73,810,404...73,835,602 		JBrowse link
G Xrcc1 X-ray repair cross complementing 1 susceptibility ISO DNA:SNP:cd: p.R399Q G>A (rs25487) (human) RGD PMID:30472145 RGD:401827275 NCBI chr 1:89,268,721...89,296,619
Ensembl chr 1:80,141,207...80,168,701 		JBrowse link
lipoatrophic diabetes mellitus term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ccr2 C-C motif chemokine receptor 2 ISO protein:increased expression:liver,serum: RGD PMID:19277603 RGD:8657358 NCBI chr 8:132,611,883...132,619,106
Ensembl chr 8:123,734,430...123,742,100 		JBrowse link
G Insr insulin receptor ISO RGD PMID:14722613 RGD:1302525 NCBI chr12:5,991,135...6,129,275
Ensembl chr12:1,197,100...1,330,883 		JBrowse link
G Lmna lamin A/C ISO ClinVar Annotator: match by term: Familial partial lipodystrophy 2 ClinVar
RGD		 PMID:262236 PMID:2007407 PMID:2338570 PMID:2733290 PMID:2753225 More... RGD:1580516 NCBI chr 2:176,237,564...176,265,301
Ensembl chr 2:173,939,751...173,960,423 		JBrowse link
proliferative diabetic retinopathy term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Adipoq adiponectin, C1Q and collagen domain containing ISO associated with Diabetes Mellitus, Type 2;protein:increased expression:aqueous humor RGD PMID:22563689 RGD:8694466 NCBI chr11:91,226,524...91,240,244
Ensembl chr11:77,721,912...77,735,564 		JBrowse link
G Ager advanced glycosylation end product-specific receptor ISO protein:increased expression:vitreous humor RGD PMID:16364297 RGD:8695978 NCBI chr20:4,152,758...4,155,956
Ensembl chr20:4,147,890...4,151,078 		JBrowse link
G Bcor BCL6 co-repressor susceptibility ISO associated with type 1 diabetes mellitus;DNA:hypomethylation:5'UTR RGD PMID:26248552 RGD:155631276 NCBI chr  X:13,282,431...13,402,254
Ensembl chr  X:10,687,732...10,729,613 		JBrowse link
G Cald1 caldesmon 1 ISO mRNA:increased expression:retina (human) RGD PMID:35692390 RGD:401851065 NCBI chr 4:64,232,906...64,414,085
Ensembl chr 4:63,265,942...63,446,932 		JBrowse link
G Calu calumenin ISO mRNA:increased expression:retina (human) RGD PMID:35692390 RGD:401851065 NCBI chr 4:58,914,456...58,941,957
Ensembl chr 4:57,948,997...57,976,593 		JBrowse link
G Cat catalase ISO associated withDiabetes Mellitus, Type 2; mRNA,protein:decreased expression, decreased activity:blood,l serum: RGD PMID:24092995 RGD:9068931 NCBI chr 3:110,297,340...110,329,526
Ensembl chr 3:89,842,399...89,874,478 		JBrowse link
G Ccl2 C-C motif chemokine ligand 2 disease_progression ISO associated with Diabetes Mellitus, Type 2;DNA:polymorphism:promoter:g.-2518A>G (human)
associated with Diabetes Mellitus;protein:increased expression:vitreous humor (human)		 RGD PMID:23549806 PMID:21850157 RGD:8548851, RGD:8549477 NCBI chr10:67,503,077...67,504,875
Ensembl chr10:67,005,424...67,007,226 		JBrowse link
G Ccn1 cellular communication network factor 1 ISO protein:increased expression:vitreous body (human) RGD PMID:22160564 RGD:329845551 NCBI chr 2:237,222,730...237,225,689
Ensembl chr 2:234,562,408...234,565,484 		JBrowse link
G Col5a2 collagen type V alpha 2 chain ISO mRNA:increased expression:retina (human) RGD PMID:35692390 RGD:401851065 NCBI chr 9:54,940,768...55,090,151
Ensembl chr 9:47,448,736...47,598,154 		JBrowse link
G Col6a3 collagen type VI alpha 3 chain ISO mRNA:increased expression:retina (human) RGD PMID:35692390 RGD:401851065 NCBI chr 9:98,809,171...98,887,060
Ensembl chr 9:91,361,583...91,439,471 		JBrowse link
G Coro1c coronin 1C ISO mRNA:increased expression:retina (human) RGD PMID:35692390 RGD:401851065 NCBI chr12:48,373,573...48,445,718
Ensembl chr12:42,712,991...42,785,179 		JBrowse link
G Enpp2 ectonucleotide pyrophosphatase/phosphodiesterase 2 disease_progression ISO protein:decreased expression:vitreous: RGD PMID:22864860 RGD:9685437 NCBI chr 7:88,092,140...88,214,758
Ensembl chr 7:86,202,350...86,324,827 		JBrowse link
G Flt1 Fms related receptor tyrosine kinase 1 ISO protein:increased expression:vitreous: RGD PMID:22868384 RGD:10402118 NCBI chr12:12,333,050...12,504,750
Ensembl chr12:7,297,292...7,468,626 		JBrowse link
G Il6r interleukin 6 receptor ISO protein:increased expression:serum RGD PMID:17401618 RGD:10402814 NCBI chr 2:177,582,020...177,646,705
Ensembl chr 2:175,298,686...175,347,536 		JBrowse link
G Map3k8 mitogen-activated protein kinase kinase kinase 8 ISO protein:increased activity:serum: RGD PMID:28724746 RGD:151356966 NCBI chr17:58,078,175...58,098,455
Ensembl chr17:53,383,131...53,403,216 		JBrowse link
G Mir23a microRNA 23a ISO miRNA:increased expression:blood serum (human) RGD PMID:24970617 RGD:155882576 NCBI chr19:40,859,769...40,859,843
Ensembl chr19:23,954,997...23,955,071 		JBrowse link
G Mir29a microRNA 29a ISO miRNA:increased expression:vitreous humor (human) RGD PMID:24970617 RGD:155882576 NCBI chr 4:60,617,955...60,618,042 JBrowse link
G Mir320a microRNA 320a ISO miRNA:increased expression:blood serum, vitreous humor (human) RGD PMID:24970617 RGD:155882576 NCBI chr15:51,926,088...51,926,169
Ensembl chr15:45,516,392...45,516,473 		JBrowse link
G Mir423 microRNA 423 ISO miRNA:decreased expression:serum RGD PMID:31422516 RGD:158014897 NCBI chr10:62,412,272...62,412,350
Ensembl chr10:61,914,133...61,914,226 		JBrowse link
G Mir93 microRNA 93 ISO miRNA:increased expression:vitreous humor (human) RGD PMID:24970617 RGD:155882576 NCBI chr12:22,156,844...22,156,930
Ensembl chr12:17,043,135...17,043,221 		JBrowse link
G Pdgfb platelet derived growth factor subunit B ISO protein:increased expression:vitreous: RGD PMID:19799585 RGD:10449447 NCBI chr 7:113,419,882...113,438,343
Ensembl chr 7:111,540,345...111,557,984 		JBrowse link
G Pparg peroxisome proliferator-activated receptor gamma onset
susceptibility		 ISO associated with Diabetes Mellitus, Type 2;DNA:snp:promoter:c.-2819A>G (human)
DNA:snp:cds:p.P12A (rs1801282) (human)		 RGD PMID:18541841 PMID:19125195 PMID:23559865 RGD:2301854, RGD:8699508, RGD:8552820 NCBI chr 4:150,095,743...150,221,104
Ensembl chr 4:148,423,194...148,548,468 		JBrowse link
G Ptpn1 protein tyrosine phosphatase, non-receptor type 1 ISO protein:increased expression:vitreous humor (human) RGD PMID:33627831 RGD:401976389 NCBI chr 3:177,056,588...177,106,424
Ensembl chr 3:156,638,769...156,687,504 		JBrowse link
G Rbp4 retinol binding protein 4 disease_progression ISO protein:increased expression:blood serum (human) RGD PMID:20233518 RGD:329853306 NCBI chr 1:245,306,349...245,313,551
Ensembl chr 1:235,893,917...235,901,399 		JBrowse link
G Serpine1 serpin family E member 1 susceptibility
disease_progression		 ISO associated with Diabetes Mellitus, Type 2;DNA:deletion:promoter:g.-676_-674delG (human)
protein:increased expression:plasma (human)		 RGD PMID:16416371 PMID:23304115 RGD:8699494, RGD:8699497 NCBI chr12:25,237,977...25,248,356
Ensembl chr12:19,601,272...19,611,657 		JBrowse link
G Serpinf1 serpin family F member 1 treatment ISO protein:increased expression:vitreous fluid (human) RGD PMID:11723044 PMID:15059706 RGD:8554895, RGD:1580135 NCBI chr10:60,748,504...60,760,898
Ensembl chr10:60,249,708...60,262,646 		JBrowse link
G Slit2 slit guidance ligand 2 ISO associated with eye disease; protein:increased expression:vitreous RGD PMID:28973045 RGD:243048421 NCBI chr14:66,829,661...67,168,517
Ensembl chr14:62,617,067...62,955,948 		JBrowse link
G Srsf6 serine and arginine rich splicing factor 6 ISO DNA:snp:exon:p.P281P (rs2235611) (human) RGD PMID:21309690 RGD:11039452 NCBI chr 3:172,009,072...172,014,395
Ensembl chr 3:151,589,535...151,594,860 		JBrowse link
G Timm44 translocase of inner mitochondrial membrane 44 ISO mRNA:decreased expression:retina RGD PMID:22003103 RGD:13463597 NCBI chr12:7,410,424...7,428,179
Ensembl chr12:2,612,581...2,629,351 		JBrowse link
G Vegfa vascular endothelial growth factor A IDA associated with Diabetes Mellitus, Type 2; protein:increased expression:retina RGD PMID:16054135 RGD:2312348 NCBI chr 9:22,452,854...22,468,194
Ensembl chr 9:14,955,300...14,970,641 		JBrowse link
severe nonproliferative diabetic retinopathy term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Pdgfrb platelet derived growth factor receptor beta ISS MouseDO NCBI chr18:56,770,348...56,809,228
Ensembl chr18:54,499,964...54,538,843 		JBrowse link
Type 2 Diabetes Mellitus 1 term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Capn10 calpain 10 ISO ClinVar Annotator: match by term: CAPN10-related condition | ClinVar Annotator: match by term: Diabetes mellitus, noninsulin-dependent, 1 | ClinVar Annotator: match by term: Type 2 diabetes mellitus 1, susceptibility to
CTD Direct Evidence: marker/mechanism		 OMIM
ClinVar
CTD		 PMID:11017071 PMID:11481585 PMID:12107250 PMID:12161543 PMID:14574648 More... NCBI chr 9:100,943,665...100,957,910
Ensembl chr 9:93,498,478...93,510,494 		JBrowse link
G Ins1 insulin 1 ISO ClinVar Annotator: match by term: Type 1 diabetes mellitus 2 ClinVar PMID:2196279 PMID:4019786 PMID:6368587 PMID:7242673 PMID:8269791 More... NCBI chr 1:261,186,119...261,186,686
Ensembl chr 1:251,244,973...251,245,536 		JBrowse link
G Ins2 insulin 2 ISO ClinVar Annotator: match by term: Type 1 diabetes mellitus 2 ClinVar PMID:2196279 PMID:4019786 PMID:6368587 PMID:7242673 PMID:8269791 More... NCBI chr 1:207,272,738...207,421,998
Ensembl chr 1:197,843,281...197,864,775 		JBrowse link
G Lipc lipase C, hepatic type ISO ClinVar Annotator: match by term: Type 1 diabetes mellitus 2 ClinVar PMID:1671786 PMID:1883393 PMID:8123642 PMID:8732782 PMID:12777476 More... NCBI chr 8:80,390,470...80,516,463
Ensembl chr 8:71,509,635...71,635,464 		JBrowse link
G Th tyrosine hydroxylase ISO ClinVar Annotator: match by term: Type 1 diabetes mellitus 2 ClinVar PMID:18162506 PMID:25741868 PMID:26467025 PMID:28492532 PMID:30456822 More... NCBI chr 1:207,500,959...207,508,276
Ensembl chr 1:198,071,503...198,109,767 		JBrowse link
Type 2 Diabetes Mellitus 5 term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Tbc1d4 TBC1 domain family, member 4 ISO ClinVar Annotator: match by term: Diabetes mellitus, noninsulin-dependent, 5 | ClinVar Annotator: match by term: TBC1D4-related condition OMIM
ClinVar		 PMID:25741868 PMID:28492532 NCBI chr15:84,670,756...84,848,876
Ensembl chr15:78,257,121...78,434,265 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  disease 19139
    disease of anatomical entity 18451
      endocrine system disease 0
        diabetes mellitus 1669
          type 2 diabetes mellitus 810
            Noninsulin-Dependent Diabetes Mellitus with Deafness 0
            Type 2 Diabetes Mellitus 1 5
            Type 2 Diabetes Mellitus 2 0
            Type 2 Diabetes Mellitus 3 0
            Type 2 Diabetes Mellitus 4 0
            Type 2 Diabetes Mellitus 5 1
            diabetic angiopathy + 204
            lipoatrophic diabetes mellitus + 3
Path 2
Term Annotations click to browse term
  disease 19139
    Developmental Disease 14674
      Congenital, Hereditary, and Neonatal Diseases and Abnormalities 13724
        genetic disease 13391
          inherited metabolic disorder 6627
            carbohydrate metabolic disorder 3418
              glucose metabolism disease 0
                diabetes mellitus 1669
                  type 2 diabetes mellitus 810
                    Noninsulin-Dependent Diabetes Mellitus with Deafness 0
                    Type 2 Diabetes Mellitus 1 5
                    Type 2 Diabetes Mellitus 2 0
                    Type 2 Diabetes Mellitus 3 0
                    Type 2 Diabetes Mellitus 4 0
                    Type 2 Diabetes Mellitus 5 1
                    diabetic angiopathy + 204
                    lipoatrophic diabetes mellitus + 3
paths to the root