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RGD DISEASE ONTOLOGY - ANNOTATIONS

RGD uses the Human Disease Ontology (DO, https://disease-ontology.org/) for disease curation across species. RGD automatically downloads each new release of the ontology on a monthly basis. Some additional terms which are required for RGD's curation purposes but are not currently covered in the official version of DO have been added. As corresponding terms are added to DO, these custom terms are retired and the DO terms substituted in existing annotations and subsequently used for curation.
Term:lung metastasis
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Accession:DOID:9009121 term browser browse the term
Definition:Transfer of a neoplasm from its primary site to the lung. Because a lung metastasis develops from some underlying cancer elsewhere in the body, it is called a “secondary” malignancy
Synonyms:xref: PMID:26265454


show annotations for term's descendants           Sort by:
lung metastasis term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ADAM28 ADAM metallopeptidase domain 28 ameliorates ISO associated with lung adenocarcinoma;
associated with lung carcinoma, breast carcinoma 		RGD PMID:22636800 PMID:26800504 RGD:11531771 RGD:153297785 NCBI chr14:8,375,169...8,438,622
Ensembl chr14:8,375,212...8,438,615 		JBrowse link
G ARHGAP5 Rho GTPase activating protein 5 ISO associated with Mammary Neoplasms, Experimental RGD PMID:20860838 RGD:126848767 NCBI chr 7:67,494,237...67,631,461
Ensembl chr 7:67,494,941...67,594,197 		JBrowse link
G ARID2 AT-rich interaction domain 2 exacerbates ISO associated with hepatocellular carcinoma, RGD PMID:32071245 RGD:150340708 NCBI chr 5:76,637,385...76,800,155
Ensembl chr 5:76,636,967...76,797,043 		JBrowse link
G AZGP1 alpha-2-glycoprotein 1, zinc-binding ameliorates ISO associated with hepatocellular carcinoma; RGD PMID:26902423 PMID:27993894 RGD:153350132 RGD:153350133 NCBI chr 3:7,867,521...7,874,857 JBrowse link
G CA12 carbonic anhydrase 12 ameliorates ISO associated with breast cancer; RGD PMID:29786141 RGD:155226861 NCBI chr 1:108,649,277...108,710,658
Ensembl chr 1:108,649,271...108,710,651 		JBrowse link
G CBLB Cbl proto-oncogene B severity ISO associated with stomach carcinoma; RGD PMID:28334634 RGD:150540337 NCBI chr13:153,480,525...153,700,115
Ensembl chr13:153,395,978...153,700,056 		JBrowse link
G CCNG1 cyclin G1 ISO RGD PMID:30565428 RGD:151361205 NCBI chr16:60,349,255...60,356,737
Ensembl chr16:60,349,258...60,356,738 		JBrowse link
G CHD4 chromodomain helicase DNA binding protein 4 ameliorates ISO associated with human colon adenocarcinoma cells in a mouse model RGD PMID:28486105 RGD:153323299 NCBI chr 5:64,071,627...64,105,212
Ensembl chr 5:64,065,992...64,105,173 		JBrowse link
G COL10A1 collagen type X alpha 1 chain ameliorates ISO associated with H1299 cell RGD PMID:33324550 RGD:150429752 NCBI chr 1:81,766,829...81,773,818
Ensembl chr 1:81,765,859...81,773,818 		JBrowse link
G CXCR4 C-X-C motif chemokine receptor 4 ameliorates ISO associated with colorectal cancer; human cells in mouse model
associated with nasopharynx carcinoma; human cells in mouse model
associated with osteosarcoma and melanoma 		RGD PMID:16000558 PMID:18071913 PMID:26498029 PMID:31938138 RGD:151665329 RGD:151893515 RGD:152023752 RGD:152177473 NCBI chr15:15,663,652...15,666,706
Ensembl chr15:15,663,494...15,667,232 		JBrowse link
G DDR1 discoidin domain receptor tyrosine kinase 1 ISO RGD PMID:29483153 RGD:151347599 NCBI chr 7:23,371,358...23,391,585
Ensembl chr 7:23,373,777...23,391,585 		JBrowse link
G DDR2 discoidin domain receptor tyrosine kinase 2 exacerbates ISO associated with tongue squamous cell carcinoma; RGD PMID:24556606 RGD:150429746 NCBI chr 4:87,749,738...87,911,818
Ensembl chr 4:87,756,168...87,911,296 		JBrowse link
G FASN fatty acid synthase ISO associated with head and neck squamous cell carcinoma RGD PMID:20604875 RGD:126790467 NCBI chr12:922,405...937,560
Ensembl chr12:920,509...937,561 		JBrowse link
G FOSL2 FOS like 2, AP-1 transcription factor subunit ISO human cells in mouse model RGD PMID:30326930 RGD:153344557 NCBI chr 3:110,820,403...110,842,903
Ensembl chr 3:110,823,666...110,843,068 		JBrowse link
G HILPDA hypoxia inducible lipid droplet associated ISO human cells in mouse model RGD PMID:31142329 RGD:153344574 NCBI chr18:19,944,929...19,947,080
Ensembl chr18:19,944,930...19,947,080 		JBrowse link
G IQSEC1 IQ motif and Sec7 domain ArfGEF 1 ISO human cells in mouse model RGD PMID:18084281 RGD:153344604 NCBI chr13:71,203,967...71,366,685
Ensembl chr13:71,031,001...71,366,684 		JBrowse link
G ITGAV integrin subunit alpha V treatment ISO human cells in rat model RGD PMID:20841470 RGD:152998949 NCBI chr15:91,604,666...91,711,843
Ensembl chr15:91,604,676...91,711,851 		JBrowse link
G MAP3K1 mitogen-activated protein kinase kinase kinase 1 ameliorates ISO associated with breast carcinoma RGD PMID:16568086 RGD:150573808 NCBI chr16:35,872,301...35,947,097
Ensembl chr16:35,872,131...35,946,987 		JBrowse link
G MAP3K8 mitogen-activated protein kinase kinase kinase 8 ameliorates ISO associated with clear cell renal cell carcinoma RGD PMID:23982215 RGD:151356974 NCBI chr10:40,714,004...40,746,390
Ensembl chr10:40,713,847...40,742,462 		JBrowse link
G MIR423 microRNA mir-423 ISO human cells in mouse model RGD PMID:30326930 RGD:153344557 NCBI chr12:46,211,525...46,211,604
Ensembl chr12:46,211,525...46,211,611 		JBrowse link
G MIR744 microRNA mir-744 treatment ISO associated with nasopharynx carcinoma RGD PMID:25961434 RGD:11056278 NCBI chr12:56,464,848...56,464,927
Ensembl chr12:56,464,848...56,464,927 		JBrowse link
G NF2 NF2, moesin-ezrin-radixin like (MERLIN) tumor suppressor ISO associated with hepatocellular carcinoma RGD PMID:26443326 RGD:11076529 NCBI chr14:46,653,869...46,726,421
Ensembl chr14:46,653,900...46,731,999 		JBrowse link
G NTRK3 neurotrophic receptor tyrosine kinase 3 ameliorates ISO associated with mammary carcinoma RGD PMID:20802235 RGD:150520014 NCBI chr 1:191,535,262...191,941,675
Ensembl chr 1:191,535,301...191,925,327 		JBrowse link
G PAGR1 PAXIP1 associated glutamate rich protein 1 ISO human cells in mouse model RGD PMID:33833989 RGD:153344568 NCBI chr 3:18,052,679...18,056,920
Ensembl chr 3:18,052,935...18,056,837 		JBrowse link
G PTPRB protein tyrosine phosphatase receptor type B treatment ISO RGD PMID:23899555 RGD:151660352 NCBI chr 5:34,656,460...34,794,838
Ensembl chr 5:34,659,964...34,794,289 		JBrowse link
G RICTOR RPTOR independent companion of MTOR complex 2 ISO human cells in mouse model RGD PMID:20978191 PMID:29809146 RGD:152995469 RGD:152995516 NCBI chr16:24,109,934...24,250,019
Ensembl chr16:24,109,939...24,311,132 		JBrowse link
G RPTOR regulatory associated protein of MTOR complex 1 ISO RGD PMID:29809146 RGD:152995516 NCBI chr12:1,709,121...1,991,844
Ensembl chr12:1,709,128...1,991,574 		JBrowse link
G SF3B4 splicing factor 3b subunit 4 ISO human cells in mouse model RGD PMID:30391496 RGD:155804298 NCBI chr 4:99,123,564...99,129,218
Ensembl chr 4:99,123,585...99,129,218 		JBrowse link
G SOX30 SRY-box transcription factor 30 ameliorates ISO RGD PMID:29739711 RGD:151660333 NCBI chr16:65,642,107...65,677,693
Ensembl chr16:65,642,223...65,678,047 		JBrowse link
G SRC SRC proto-oncogene, non-receptor tyrosine kinase treatment
ameliorates 		ISO associated with breast cancer;
associated with nasopharynx carcinoma; 		RGD PMID:15753384 PMID:27078847 RGD:150521726 RGD:1581400 NCBI chr17:40,470,970...40,524,862
Ensembl chr17:40,471,009...40,524,860 		JBrowse link
G TES testin LIM domain protein ameliorates ISO associated with stomach cancer;
associated with breast cancer; 		RGD PMID:22957844 PMID:30728082 RGD:597621668 RGD:597621672 NCBI chr18:29,895,878...29,936,248
Ensembl chr18:29,895,882...29,936,233 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  disease 15439
    disease of cellular proliferation 7381
      Neoplastic Processes 713
        Neoplasm Metastasis 485
          lung metastasis 31
Path 2
Term Annotations click to browse term
  disease 15439
    disease of anatomical entity 15108
      respiratory system disease 4882
        thoracic disease 3750
          Thoracic Neoplasms 980
            Respiratory Tract Neoplasms 977
              Lung Neoplasms 954
                lung cancer 747
                  lung metastasis 31
paths to the root