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RGD DISEASE ONTOLOGY - ANNOTATIONS

RGD uses the Human Disease Ontology (DO, https://disease-ontology.org/) for disease curation across species. RGD automatically downloads each new release of the ontology on a monthly basis. Some additional terms which are required for RGD's curation purposes but are not currently covered in the official version of DO have been added. As corresponding terms are added to DO, these custom terms are retired and the DO terms substituted in existing annotations and subsequently used for curation.
Term:lung metastasis
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Accession:DOID:9009121 term browser browse the term
Definition:Transfer of a neoplasm from its primary site to the lung. Because a lung metastasis develops from some underlying cancer elsewhere in the body, it is called a “secondary” malignancy
Synonyms:xref: PMID:26265454


show annotations for term's descendants           Sort by:
lung metastasis term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Adam28 ADAM metallopeptidase domain 28 ameliorates ISO associated with lung carcinoma, breast carcinoma
associated with lung adenocarcinoma; 		RGD PMID:22636800 PMID:26800504 RGD:153297785, RGD:11531771 NCBI chr15:43,774,463...43,840,726
Ensembl chr15:50,127,516...50,250,526 		JBrowse link
G Arhgap5 Rho GTPase activating protein 5 ISO associated with Mammary Neoplasms, Experimental RGD PMID:20860838 RGD:126848767 NCBI chr 6:75,711,199...75,774,636
Ensembl chr 6:75,711,515...75,774,636 		JBrowse link
G Arid2 AT-rich interaction domain 2 exacerbates ISO associated with hepatocellular carcinoma, RGD PMID:32071245 RGD:150340708 NCBI chr 7:127,447,192...127,565,987
Ensembl chr 7:129,324,137...129,443,187 		JBrowse link
G Azgp1 alpha-2-glycoprotein 1, zinc-binding ameliorates ISO associated with hepatocellular carcinoma; RGD PMID:27993894 PMID:26902423 RGD:153350132, RGD:153350133 NCBI chr12:22,044,685...22,051,248
Ensembl chr12:22,044,751...22,053,020 		JBrowse link
G Ca12 carbonic anhydrase 12 ameliorates ISO associated with breast cancer; RGD PMID:29786141 RGD:155226861 NCBI chr 8:76,169,723...76,225,465
Ensembl chr 8:76,169,815...76,225,465 		JBrowse link
G Cblb Cbl proto-oncogene B severity ISO associated with stomach carcinoma; RGD PMID:28334634 RGD:150540337 NCBI chr11:48,589,878...48,756,940
Ensembl chr11:62,061,653...62,225,778 		JBrowse link
G Ccng1 cyclin G1 ISO RGD PMID:30565428 RGD:151361205 NCBI chr10:25,176,231...25,182,604
Ensembl chr10:25,677,885...25,683,766 		JBrowse link
G Chd4 chromodomain helicase DNA binding protein 4 ameliorates ISO associated with human colon adenocarcinoma cells in a mouse model RGD PMID:28486105 RGD:153323299 NCBI chr 4:157,898,503...157,931,632
Ensembl chr 4:159,584,654...159,617,866 		JBrowse link
G Col10a1 collagen type X alpha 1 chain ameliorates ISO associated with H1299 cell RGD PMID:33324550 RGD:150429752 NCBI chr20:38,183,103...38,189,488
Ensembl chr20:39,716,822...39,751,440 		JBrowse link
G Cxcr4 C-X-C motif chemokine receptor 4 ameliorates ISO associated with colorectal cancer; human cells in mouse model
associated with nasopharynx carcinoma; human cells in mouse model
associated with osteosarcoma and melanoma 		RGD PMID:31938138 PMID:16000558 PMID:26498029 PMID:18071913 RGD:151665329, RGD:151893515, RGD:152023752, RGD:152177473 NCBI chr13:42,630,383...42,634,288
Ensembl chr13:42,630,104...42,634,459 		JBrowse link
G Ddr1 discoidin domain receptor tyrosine kinase 1 ISO RGD PMID:29483153 RGD:151347599 NCBI chr20:3,047,269...3,069,277
Ensembl chr20:3,050,375...3,069,276 		JBrowse link
G Ddr2 discoidin domain receptor tyrosine kinase 2 exacerbates ISO associated with tongue squamous cell carcinoma; RGD PMID:24556606 RGD:150429746 NCBI chr13:82,193,623...82,318,229
Ensembl chr13:84,731,180...84,850,288 		JBrowse link
G Fasn fatty acid synthase ISO associated with head and neck squamous cell carcinoma RGD PMID:20604875 RGD:126790467 NCBI chr10:106,570,415...106,588,581
Ensembl chr10:106,570,413...106,588,583 		JBrowse link
G Fosl2 FOS like 2, AP-1 transcription factor subunit ISO human cells in mouse model RGD PMID:30326930 RGD:153344557 NCBI chr 6:30,017,952...30,039,269
Ensembl chr 6:30,021,916...30,039,406 		JBrowse link
G Hilpda hypoxia inducible lipid droplet-associated ISO human cells in mouse model RGD PMID:31142329 RGD:153344574 NCBI chr 4:58,836,463...58,839,423
Ensembl chr 4:58,836,463...58,839,423 		JBrowse link
G Iqsec1 IQ motif and Sec7 domain ArfGEF 1 ISO human cells in mouse model RGD PMID:18084281 RGD:153344604 NCBI chr 4:123,168,719...123,488,300
Ensembl chr 4:124,725,917...125,045,550 		JBrowse link
G Itgav integrin subunit alpha V treatment ISO human cells in rat model RGD PMID:20841470 RGD:152998949 NCBI chr 3:89,245,382...89,333,512
Ensembl chr 3:89,245,095...89,333,511 		JBrowse link
G Map3k1 mitogen-activated protein kinase kinase kinase 1 ameliorates ISO associated with breast carcinoma RGD PMID:16568086 RGD:150573808 NCBI chr 2:45,081,889...45,150,555
Ensembl chr 2:45,081,889...45,149,897 		JBrowse link
G Map3k8 mitogen-activated protein kinase kinase kinase 8 ameliorates ISO associated with clear cell renal cell carcinoma RGD PMID:23982215 RGD:151356974 NCBI chr17:53,382,908...53,403,216
Ensembl chr17:58,078,320...58,098,452 		JBrowse link
G Mir423 microRNA 423 ISO human cells in mouse model RGD PMID:30326930 RGD:153344557 NCBI chr10:62,412,272...62,412,350 JBrowse link
G Mir494 microRNA 494 ameliorates ISO associated with hepatocellular carcinoma RGD PMID:25820676 PMID:28055013 RGD:155900754, RGD:156430322 NCBI chr 6:134,550,115...134,550,197
Ensembl chr 6:134,550,114...134,550,198 		JBrowse link
G Nf2 NF2, moesin-ezrin-radixin like (MERLIN) tumor suppressor ISO associated with hepatocellular carcinoma RGD PMID:26443326 RGD:11076529 NCBI chr14:83,850,894...83,934,263
Ensembl chr14:83,850,894...83,934,151 		JBrowse link
G Ntrk3 neurotrophic receptor tyrosine kinase 3 ameliorates ISO associated with mammary carcinoma RGD PMID:20802235 RGD:150520014 NCBI chr 1:141,526,192...141,913,575
Ensembl chr 1:141,542,569...141,913,004 		JBrowse link
G Pagr1 Paxip1-associated glutamate-rich protein 1 ISO human cells in mouse model RGD PMID:33833989 RGD:153344568 NCBI chr 1:181,622,698...181,625,024 JBrowse link
G Ptprb protein tyrosine phosphatase, receptor type, B treatment ISO RGD PMID:23899555 RGD:151660352 NCBI chr 7:53,816,197...53,920,760
Ensembl chr 7:53,816,097...53,920,760 		JBrowse link
G Rictor RPTOR independent companion of MTOR, complex 2 ISO human cells in mouse model RGD PMID:20978191 PMID:29809146 RGD:152995469, RGD:152995516 NCBI chr 2:57,539,279...57,631,291
Ensembl chr 2:57,539,311...57,631,288 		JBrowse link
G Rptor regulatory associated protein of MTOR, complex 1 ISO RGD PMID:29809146 RGD:152995516 NCBI chr10:104,878,487...105,176,986
Ensembl chr10:105,376,943...105,675,413 		JBrowse link
G Sf3b4 splicing factor 3B subunit 4 ISO human cells in mouse model RGD PMID:30391496 RGD:155804298 NCBI chr 2:186,421,667...186,426,419
Ensembl chr 2:186,421,636...186,426,833 		JBrowse link
G Sox30 SRY-box transcription factor 30 ameliorates ISO RGD PMID:29739711 RGD:151660333 NCBI chr10:30,417,499...30,446,441
Ensembl chr10:30,919,778...30,948,415 		JBrowse link
G Src SRC proto-oncogene, non-receptor tyrosine kinase treatment
ameliorates 		ISO associated with breast cancer;
associated with nasopharynx carcinoma; 		RGD PMID:15753384 PMID:27078847 RGD:1581400, RGD:150521726 NCBI chr 3:166,511,616...166,559,463
Ensembl chr 3:166,511,985...166,559,462 		JBrowse link
G Tes testin LIM domain protein ameliorates ISO associated with breast cancer;
associated with stomach cancer; 		RGD PMID:22957844 PMID:30728082 RGD:597621668, RGD:597621672 NCBI chr 4:46,331,257...46,369,782
Ensembl chr 4:46,331,257...46,369,780 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  disease 19167
    disease of cellular proliferation 7905
      Neoplastic Processes 743
        Neoplasm Metastasis 503
          lung metastasis 32
Path 2
Term Annotations click to browse term
  disease 19167
    disease of anatomical entity 18473
      respiratory system disease 5247
        thoracic disease 4057
          Thoracic Neoplasms 1023
            Respiratory Tract Neoplasms 1019
              Lung Neoplasms 994
                lung cancer 773
                  lung metastasis 32
paths to the root