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RGD DISEASE ONTOLOGY - ANNOTATIONS

RGD uses the Human Disease Ontology (DO, https://disease-ontology.org/) for disease curation across species. RGD automatically downloads each new release of the ontology on a monthly basis. Some additional terms which are required for RGD's curation purposes but are not currently covered in the official version of DO have been added. As corresponding terms are added to DO, these custom terms are retired and the DO terms substituted in existing annotations and subsequently used for curation.
Term:Lead Poisoning
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Accession:DOID:9008914 term browser browse the term
Definition:Poisoning that results from chronic or acute ingestion, injection, inhalation, or skin absorption of LEAD or lead compounds.
Synonyms:exact_synonym: Lead Poisonings
 primary_id: MESH:D007855


show annotations for term's descendants           Sort by:
Lead Poisoning term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Alad aminolevulinate dehydratase IDA
IEP
ISO		 protein:decreased activity:blood (rat)
CTD Direct Evidence: marker/mechanism		 CTD
RGD		 PMID:21396434 PMID:23792432 PMID:24631795 PMID:16597373 PMID:19647414 RGD:1599014, RGD:4144142 NCBI chr 5:80,977,562...80,987,901
Ensembl chr 5:75,961,993...75,972,474 		JBrowse link
G Glul glutamate-ammonia ligase IEP protein:increased expression:stellate ganglion RGD PMID:29457680 RGD:401794593 NCBI chr13:68,519,500...68,585,554
Ensembl chr13:66,025,630...66,035,108 		JBrowse link
G Hfe homeostatic iron regulator ISO CTD Direct Evidence: marker/mechanism CTD PMID:20659343 NCBI chr17:41,841,302...41,849,359
Ensembl chr17:41,413,451...41,421,502 		JBrowse link
G Mmp9 matrix metallopeptidase 9 ISO CTD Direct Evidence: marker/mechanism CTD PMID:16700817 NCBI chr 3:174,103,474...174,111,434
Ensembl chr 3:153,683,858...153,692,120 		JBrowse link
G Mt4 metallothionein 4 ISO CTD Direct Evidence: marker/mechanism CTD PMID:19921116 NCBI chr19:10,863,813...10,865,909
Ensembl chr19:10,863,813...10,865,909 		JBrowse link
G Nqo1 NAD(P)H quinone dehydrogenase 1 treatment IEP RGD PMID:28178683 RGD:13440092 NCBI chr19:52,205,374...52,220,267
Ensembl chr19:35,295,573...35,310,557 		JBrowse link
G Qdpr quinoid dihydropteridine reductase IEP protein:increased activity:brain, caudate nucleus (rat) RGD PMID:2359144 RGD:5128598 NCBI chr14:69,882,776...69,896,378
Ensembl chr14:65,670,131...65,683,854 		JBrowse link
G Ryr1 ryanodine receptor 1 ISO mRNA:decreased expression:peripheral blood mononuclear cell RGD PMID:30661027 RGD:329812013 NCBI chr 1:93,420,078...93,551,305
Ensembl chr 1:84,292,578...84,423,812 		JBrowse link
G Vdr vitamin D receptor ISO CTD Direct Evidence: marker/mechanism CTD PMID:20692022 PMID:23433214 NCBI chr 7:130,864,764...130,916,757
Ensembl chr 7:128,987,981...129,037,677 		JBrowse link
G Xpo5 exportin 5 ISO CTD Direct Evidence: marker/mechanism CTD PMID:28042866 NCBI chr 9:22,237,760...22,275,745
Ensembl chr 9:14,740,182...14,778,171 		JBrowse link
G Xrcc3 X-ray repair cross complementing 3 ISO CTD Direct Evidence: marker/mechanism CTD PMID:23803535 NCBI chr 6:136,684,558...136,694,822
Ensembl chr 6:130,863,959...130,872,444 		JBrowse link
Nervous System Lead Poisoning term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Alad aminolevulinate dehydratase ISO CTD Direct Evidence: marker/mechanism CTD PMID:21439310 NCBI chr 5:80,977,562...80,987,901
Ensembl chr 5:75,961,993...75,972,474 		JBrowse link
G Ep300 E1A binding protein p300 IEP mRNA:increased expression:hippocampus RGD PMID:24291742 RGD:9588309 NCBI chr 7:114,987,857...115,058,652
Ensembl chr 7:113,106,247...113,136,088
Ensembl chr 7:113,106,247...113,136,088 		JBrowse link
Nervous System Lead Poisoning, Adult term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Slc6a1 solute carrier family 6 member 1 IEP protein:increased expression:brain, synaptosome RGD PMID:15149801 RGD:1643208 NCBI chr 4:149,004,447...149,037,840
Ensembl chr 4:147,466,965...147,482,293 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  disease 19140
    Chemically-Induced Disorders 1467
      Poisoning 790
        Lead Poisoning 13
          Nervous System Lead Poisoning + 3
paths to the root