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RGD DISEASE ONTOLOGY - ANNOTATIONS

RGD uses the Human Disease Ontology (DO, https://disease-ontology.org/) for disease curation across species. RGD automatically downloads each new release of the ontology on a monthly basis. Some additional terms which are required for RGD's curation purposes but are not currently covered in the official version of DO have been added. As corresponding terms are added to DO, these custom terms are retired and the DO terms substituted in existing annotations and subsequently used for curation.
Term:Thecoma
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Accession:DOID:9008813 term browser browse the term
Definition:A gonadal stromal neoplasm composed only of THECA CELLS, occurring mostly in the postmenopausal OVARY. It is filled with lipid-containing spindle cells and produces ESTROGENS that can lead to ENDOMETRIAL HYPERPLASIA; UTERINE HEMORRHAGE; or other malignancies in postmenopausal women and sexual precocity in girls. When tumors containing theca cells also contain FIBROBLASTS, they are identified as thecoma-fibroma tumors with less active hormone production.
Synonyms:exact_synonym: Theca Cell Tumor;   Theca Cell Tumors;   Thecomas
 narrow_synonym: Thecoma, somatic
 primary_id: MESH:D013798

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Thecoma term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Gnai2 G protein subunit alpha i2 ISO ClinVar Annotator: match by term: Thecoma, somatic ClinVar PMID:2116665 NCBI chrNW_004955532:2,059,038...2,079,120
Ensembl chrNW_004955532:2,059,038...2,079,957 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  disease 14341
    disease of cellular proliferation 6899
      Neoplasms by Histologic Type 4721
        Gonadal Tissue Neoplasms 128
          sex cord-gonadal stromal tumor 36
            Thecoma 1
              testicular thecoma 0
Path 2
Term Annotations click to browse term
  disease 14341
    disease of anatomical entity 14034
      Urogenital Diseases 4572
        Female Urogenital Diseases and Pregnancy Complications 2416
          Female Urogenital Diseases 2005
            female reproductive system disease 2002
              Adnexal Diseases 1011
                ovarian disease 1004
                  Ovarian Neoplasms 704
                    Thecoma 1
                      testicular thecoma 0
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