Respiratory Tract Infections - Ontology Report - Rat Genome Database

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RGD DISEASE ONTOLOGY - ANNOTATIONS

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RGD uses the Human Disease Ontology (DO, https://disease-ontology.org/) for disease curation across species. RGD automatically downloads each new release of the ontology on a monthly basis. Some additional terms which are required for RGD's curation purposes but are not currently covered in the official version of DO have been added. As corresponding terms are added to DO, these custom terms are retired and the DO terms substituted in existing annotations and subsequently used for curation.

Term:	Respiratory Tract Infections	go back to main search page
Accession:	DOID:9008680	browse the term
Definition:	Invasion of the host RESPIRATORY SYSTEM by microorganisms, usually leading to pathological processes or diseases.
Synonyms:	exact_synonym:	Respiratory Infection, Upper; Respiratory Infections; Respiratory Tract Infection; Upper Respiratory Infections; Upper Respiratory Tract Infections
	primary_id:	MESH:D012141; RDO:0000329

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Rat (491) Mouse (498) Human (3143) Chinchilla (405) Bonobo (480) Dog (470) Squirrel (426) Pig (468) Green Monkey (464) Naked Mole-rat (408) All
Genes (470)

Respiratory Tract Infections

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

brain derived neurotrophic factor

protein:decreased expression:platelet, serum

NCBI chr21:48,191,580...48,243,699
Ensembl chr21:48,192,670...48,204,480

G

C-X-C motif chemokine receptor 3

NCBI chr X:55,882,433...55,884,582
Ensembl chr X:55,882,433...55,884,582

G

fibulin 5

CTD Direct Evidence: marker/mechanism

NCBI chr 8:1,162,203...1,231,809
Ensembl chr 8:1,162,923...1,231,719

G

interleukin 13

Severe Acute Respiratory Syndrome

NCBI chr11:20,957,870...20,961,391
Ensembl chr11:20,958,464...20,961,388

G

interleukin 16

protein:increased expression:serum

NCBI chr 3:56,473,485...56,575,504
Ensembl chr 3:56,473,486...56,575,104

G

interleukin 4

associated with Asthma

NCBI chr11:20,972,693...20,981,539
Ensembl chr11:20,972,690...20,981,534

G

interleukin 6 receptor

DNA:polymorphisms:promoter, exon:-183G>A (human)

NCBI chr 7:42,877,731...42,920,149
Ensembl chr 7:42,880,885...42,920,090

G

interferon regulatory factor 1

NCBI chr11:20,773,801...20,781,106
Ensembl chr11:20,760,120...20,781,608

G

interferon regulatory factor 3

NCBI chr 1:106,875,016...106,879,065
Ensembl chr 1:106,875,118...106,879,065

G

leptin receptor

CTD Direct Evidence: marker/mechanism

NCBI chr 5:44,684,118...44,775,626
Ensembl chr 5:44,688,109...44,775,636

G

mannose binding lectin 1

susceptibility

protein:decreased secretion:serum (human)
DNA:SNP:exon:p.G54D(rs1800450)(human)
DNA:polymorphisms:5' utr, exon:multiple (human)

PMID:15249448 PMID:19169708 PMID:19767106

RGD:4889439 RGD:4889453 RGD:8693755

NCBI chr 4:29,419,886...29,424,377

G

MX dynamin like GTPase 1

protein:increased expression:blood (human)

NCBI chr31:35,898,206...35,929,802
Ensembl chr31:35,860,590...35,951,350

G

retinitis pigmentosa GTPase regulator

CTD Direct Evidence: marker/mechanism

NCBI chr X:33,056,371...33,105,036
Ensembl chr X:32,745,020...33,330,841

G

tumor necrosis factor

Severe Acute Respiratory Syndrome; protein:increased expression:serum

NCBI chr12:1,074,561...1,076,425
Ensembl chr12:1,074,552...1,076,425

allergic bronchopulmonary aspergillosis

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

C-C motif chemokine ligand 17

associated with Cystic Fibrosis

NCBI chr 2:59,001,463...59,014,347
Ensembl chr 2:59,001,464...59,005,230

G

chemokine (C-C motif) receptor 1

NCBI chr20:42,421,356...42,427,177
Ensembl chr20:42,421,356...42,426,958

G

C-C motif chemokine receptor 2

NCBI chr20:42,305,344...42,313,258
Ensembl chr20:42,307,580...42,308,698

G

CF transmembrane conductance regulator

DNA:mutations: :

NCBI chr14:56,290,417...56,452,919
Ensembl chr14:56,290,275...56,453,977

G

major histocompatibility complex, class II, DQ beta 1

susceptibility

associated with cystic fibrosis; DNA:polymorphisms: :DQB1*06:02, DQB1*02:01(human)

NCBI chr12:2,305,307...2,307,711

G

MHC class II DLA DRB1 beta chain

susceptibility

associated with cystic fibrosis; DNA:polymorphisms: :

NCBI chr12:2,151,409...2,164,564

G

intercellular adhesion molecule 1

NCBI chr20:50,818,715...50,827,914
Ensembl chr20:50,818,715...50,827,914

G

interleukin 1 alpha

NCBI chr17:36,969,581...36,979,445
Ensembl chr17:36,970,573...36,979,435

G

mannose binding lectin 1

susceptibility

Chronic Necrotizing Pulmonary Aspergillosis; DNA:missense mutation:exon:p.R52C (human)
DNA:SNP:intron:1011G>A(human)

PMID:11474427 PMID:16487239

RGD:4889577 RGD:8693711

NCBI chr 4:29,419,886...29,424,377

G

toll like receptor 9

susceptibility

DNA:SNP:promoter:g.-1237T>C (rs5743836) (human)

PMID:18275280 PMID:18936185

RGD:5130858 RGD:5130863

NCBI chr20:37,529,322...37,547,117
Ensembl chr20:37,542,340...37,547,114
Ensembl chr20:37,542,340...37,547,114

G

tumor necrosis factor

NCBI chr12:1,074,561...1,076,425
Ensembl chr12:1,074,552...1,076,425

G

TNF receptor superfamily member 1A

susceptibility

DNA:snps:5' utr, exon:g.-609G>T rs4149570, g.36A>G rs767455 (human)

NCBI chr27:38,641,837...38,654,693
Ensembl chr27:38,638,753...38,700,282

allergic rhinitis

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

ATP binding cassette subfamily B member 1

severity

DNA:snp:exon:c.1236C>T (human)

NCBI chr14:13,644,891...13,852,829
Ensembl chr14:13,542,647...13,742,727

G

angiotensin I converting enzyme

no_association

DNA:deletion:intron:IVS16+1464-1751del (human)

NCBI chr 9:11,497,182...11,516,362
Ensembl chr 9:11,497,182...11,516,358

G

B9 domain containing 2

treatment

NCBI chr 1:112,621,832...112,627,726
Ensembl chr 1:112,621,633...112,643,885

G

BCL2 apoptosis regulator

mRNA, protein:increased expression:nasal mucosa (rat)

NCBI chr 1:13,733,849...13,900,653
Ensembl chr 1:13,731,406...13,900,658

G

catalase

CTD Direct Evidence: marker/mechanism

NCBI chr18:33,383,005...33,422,447
Ensembl chr18:33,383,005...33,422,447

G

C-C motif chemokine ligand 26

protein:increased expression:oronasal secretion (human)

NCBI chr 6:7,151,352...7,154,509
Ensembl chr 6:7,151,212...7,154,726

G

CD40 molecule

protein:increased expression:lymphocyte

NCBI chr24:33,352,992...33,383,488
Ensembl chr24:33,372,930...33,383,301

G

CD40 ligand

protein:increased expression:lymphocyte

NCBI chr X:107,001,421...107,023,007
Ensembl chr X:107,010,890...107,023,006

G

claudin 3

CTD Direct Evidence: marker/mechanism

NCBI chr 6:6,534,229...6,535,237

G

claudin 7

CTD Direct Evidence: marker/mechanism

NCBI chr 5:32,223,985...32,225,795
Ensembl chr 5:32,224,040...32,226,168

G

cytotoxic T-lymphocyte associated protein 4

treatment

NCBI chr37:12,647,712...12,653,874
Ensembl chr37:12,634,563...12,653,874

G

coagulation factor II, thrombin

protein:increased expression:nasal mucus

NCBI chr18:42,782,744...42,799,531
Ensembl chr18:42,782,751...42,799,459

G

glutamate ionotropic receptor AMPA type subunit 1

CTD Direct Evidence: marker/mechanism

NCBI chr 4:55,801,269...56,103,383
Ensembl chr 4:55,803,296...56,103,669

G

glutamate ionotropic receptor AMPA type subunit 2

CTD Direct Evidence: marker/mechanism

NCBI chr15:54,634,332...54,710,711
Ensembl chr15:54,634,335...54,708,184

G

heme oxygenase 1

CTD Direct Evidence: marker/mechanism

NCBI chr10:28,744,404...28,751,544
Ensembl chr10:28,743,795...28,751,773

G

histamine receptor H1

CTD Direct Evidence: marker/mechanism

NCBI chr20:7,160,903...7,236,147
Ensembl chr20:7,162,393...7,235,869

G

interferon gamma

treatment

CTD Direct Evidence: marker/mechanism
associated with Asthma

PMID:12787306 PMID:18510219 PMID:29871060

RGD:10755770 RGD:7829803

NCBI chr10:10,406,866...10,411,698
Ensembl chr10:10,406,867...10,411,698

G

interleukin 10

treatment

CTD Direct Evidence: marker/mechanism

PMID:23253209 PMID:23883806 PMID:36127783

RGD:7364793 RGD:7364818

NCBI chr 7:5,933,285...5,937,057
Ensembl chr 7:5,933,285...5,937,057

G

interleukin 13

susceptibility
no_association

CTD Direct Evidence: marker/mechanism
DNA:SNPs:promoter, cds:-1112C>T, p.R130Q (rs1800925, rs20541) (human)

NCBI chr11:20,957,870...20,961,391
Ensembl chr11:20,958,464...20,961,388

G

interleukin 13 receptor subunit alpha 2

protein:increased expression:serum

NCBI chr X:87,747,373...87,776,797
Ensembl chr X:87,747,373...87,776,798

G

interleukin 17A

susceptibility

DNA:snp:promoter:c.-444A>G (human)
mRNA:increased expression:peripheral blood mononuclear cell (human)

PMID:21535180 PMID:22507625

RGD:5147409 RGD:9068429

NCBI chr12:19,854,129...19,862,521
Ensembl chr12:19,854,129...19,862,513

G

interleukin 18

no_association
severity

DNA:SNP:promoter:-140C>G (rs360721) (human)
DNA:SNP:promoter:-137G>C (rs187238) (human)

NCBI chr 5:20,972,742...20,995,327
Ensembl chr 5:20,972,871...20,995,348

G

interleukin 1 beta

protein:increased expression:nasal mucus

NCBI chr17:37,019,329...37,033,388
Ensembl chr17:37,019,329...37,024,458

G

interleukin 2

NCBI chr19:17,750,780...17,756,394
Ensembl chr19:17,750,780...17,756,394

G

interleukin 4

treatment

CTD Direct Evidence: marker/mechanism

PMID:8908280 PMID:9893928 PMID:14653048 PMID:24620662 PMID:36127783

RGD:11522769 RGD:7829796 RGD:7829802 RGD:7829827

NCBI chr11:20,972,693...20,981,539
Ensembl chr11:20,972,690...20,981,534

G

interleukin 5

treatment

PMID:23934070 PMID:24620662

RGD:11354976 RGD:11522769

NCBI chr11:20,825,469...20,827,269
Ensembl chr11:20,825,469...20,827,269

G

integrin subunit beta 2

treatment

NCBI chr31:38,520,733...38,547,003
Ensembl chr31:38,521,103...38,547,018

G

low affinity immunoglobulin gamma Fc region receptor III

susceptibility

DNA:polymorphism:exon:p.F158V(rs396991)(human)

NCBI chr38:21,054,870...21,060,948

G

mannose receptor C-type 1

CTD Direct Evidence: marker/mechanism

NCBI chr 2:19,090,580...19,185,943
Ensembl chr 2:19,069,120...19,185,691

G

mucin 1, cell surface associated

severity

mRNA,protein:decreased expression:nasal mucosa

NCBI chr 7:42,338,939...42,344,690
Ensembl chr 7:42,340,375...42,344,690

G

mucin 5AC, oligomeric mucus/gel-forming

mRNA, protein:increased expression:nasal cavity epithelium

NCBI chr18:45,471,232...45,498,961

G

nucleotide binding oligomerization domain containing 2

mRNA:increased expression:nasal mucosa (human)

NCBI chr 2:64,636,850...64,667,232
Ensembl chr 2:64,635,519...64,667,232

G

occludin

CTD Direct Evidence: marker/mechanism

NCBI chr 2:54,500,299...54,545,430
Ensembl chr 2:54,500,299...54,545,430

G

paraoxonase 1

severity

protein:decreased activity:plasma (human)

NCBI chr14:20,565,620...20,600,774
Ensembl chr14:20,565,641...20,642,985

G

protein kinase cGMP-dependent 1

protein:increased expression:nasal cavity epithelium

NCBI chr26:35,732,974...36,932,744
Ensembl chr26:35,737,242...36,932,729

G

prostaglandin-endoperoxide synthase 2

CTD Direct Evidence: marker/mechanism

NCBI chr 7:19,668,079...19,674,903
Ensembl chr 7:19,668,082...19,674,903

G

secretoglobin family 1A member 1

mRNA:decreased expression:nasal mucosa, lung

NCBI chr18:54,187,487...54,191,493
Ensembl chr18:54,187,487...54,191,482

G

secretoglobin family 3A member 2

susceptibility

DNA:SNP: :rs7726552 (human)

NCBI chr 2:42,147,596...42,151,224
Ensembl chr 2:42,147,596...42,151,191

G

serpin family E member 1

mRNA:increased expression:nasal mucosa (mouse)

NCBI chr 6:8,719,547...8,727,160
Ensembl chr 6:8,720,825...8,726,301

G

tachykinin receptor 1

mRNA:increased expression:nasal mucosa

NCBI chr17:48,038,010...48,178,971
Ensembl chr17:48,038,010...48,178,971

G

toll like receptor 2

severity

mRNA:decreased expression:nasal mucosa:
DNA:polymorphism:cds:p.R753Q(human)
protein:increased expression:neutrophil:

PMID:18219831 PMID:18381801 PMID:22402138 PMID:22555057

RGD:7800732 RGD:7800742 RGD:8552972 RGD:8552993

NCBI chr15:51,454,557...51,465,429
Ensembl chr15:51,454,695...51,465,241

G

toll like receptor 4

treatment
severity
no_association
susceptibility

protein:decreased expression:nasal mucosa:
DNA:polymorphism:cds:p.D299G(human)
DNA:polymorphism: :4216G>C(human)
protein:increased expression:nasal lavage,leukocyte, bone marrow:
DNA:SNP: :rs1927911(human)

PMID:17069098 PMID:19763595 PMID:22402138 PMID:22555057 PMID:22577387 More...

RGD:4145354 RGD:7800732 RGD:7800736 RGD:7800738 RGD:7800740 RGD:8552993

NCBI chr11:71,356,390...71,367,166
Ensembl chr11:71,356,390...71,367,165

G

toll like receptor 9

protein:decreased expression:nasal mucosa:

NCBI chr20:37,529,322...37,547,117
Ensembl chr20:37,542,340...37,547,114
Ensembl chr20:37,542,340...37,547,114

Allergic Rhinoconjunctivitis

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

interleukin 3

susceptibility

DNA:SNP: :rs40401(human)

NCBI chr11:20,330,480...20,332,668
Ensembl chr11:20,330,480...20,332,668

aspergillosis

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

advanced glycosylation end-product specific receptor

DNA:SNP:promoter:-374T>A (human)

NCBI chr12:1,574,251...1,577,410
Ensembl chr12:1,574,251...1,577,129

G

C-C motif chemokine ligand 19

associated with Neutropenia;mRNA:increased expression:lung

NCBI chr11:51,357,706...51,359,207
Ensembl chr11:51,340,530...51,359,365

G

C-C motif chemokine receptor 7

associated with Neutropenia

NCBI chr 9:22,077,976...22,092,818
Ensembl chr 9:22,068,775...22,090,656

G

CD209 molecule

NCBI chr20:52,517,759...52,542,085
Ensembl chr20:52,518,036...52,520,942

G

CF transmembrane conductance regulator

severity

NCBI chr14:56,290,417...56,452,919
Ensembl chr14:56,290,275...56,453,977

G

C-type lectin domain family 1 member A

susceptibility

ClinVar Annotator: match by term: Aspergillosis, susceptibility to

PMID:25741868 PMID:29489751

NCBI chr27:35,896,421...35,920,649
Ensembl chr27:35,853,099...36,007,157

G

C-type lectin domain containing 7A

susceptibility

ClinVar Annotator: match by term: CLEC7A-related condition

PMID:19864674 PMID:20807886 PMID:24033266 PMID:25741868 PMID:28492532

NCBI chr27:35,852,685...35,885,673
Ensembl chr27:35,853,099...36,007,157

G

C-reactive protein

treatment

NCBI chr38:22,396,787...22,398,180
Ensembl chr38:22,396,263...22,399,166

G

interleukin 15

DNA:polymorphism (human)

NCBI chr19:1,339,607...1,364,762
Ensembl chr19:1,339,967...1,364,762

G

mannose binding lectin 1

susceptibility

NCBI chr 4:29,419,886...29,424,377

G

S100 calcium binding protein B

DNA:SNP: :427C>T (human)

NCBI chr31:39,783,990...39,788,289
Ensembl chr31:39,784,506...39,788,183

G

toll like receptor 1

susceptibility

DNA:SNPs: :p.R80T, p.N248S (human)

NCBI chr 3:73,504,359...73,544,822
Ensembl chr 3:73,539,715...73,544,624

G

toll like receptor 2

mRNA:increased expression:lung

NCBI chr15:51,454,557...51,465,429
Ensembl chr15:51,454,695...51,465,241

G

toll like receptor 6

susceptibility

DNA:SNP: :p.S249P (human)

NCBI chr 3:73,504,357...73,523,964
Ensembl chr 3:73,520,706...73,523,099

aspiration pneumonia

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

angiotensin I converting enzyme

associated with Cerebrovascular Accident

NCBI chr 9:11,497,182...11,516,362
Ensembl chr 9:11,497,182...11,516,358

G

endothelin 1

protein:increased secretion:plasma (rat)

NCBI chr35:11,808,892...11,815,383
Ensembl chr35:11,808,892...11,815,383

G

interleukin 1 alpha

protein:increased expression:Bronchoalveolar Lavage Fluid

NCBI chr17:36,969,581...36,979,445
Ensembl chr17:36,970,573...36,979,435

G

nitric oxide synthase 2

CTD Direct Evidence: marker/mechanism

NCBI chr 9:42,171,821...42,210,217
Ensembl chr 9:42,171,821...42,208,588

G

tumor necrosis factor

protein:increased expression:Bronchoalveolar Lavage Fluid

NCBI chr12:1,074,561...1,076,425
Ensembl chr12:1,074,552...1,076,425

Bacterial Lung Diseases

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

C-X-C motif chemokine ligand 8

severity

protein:increased expression:nasal mucus (human)

NCBI chr13:62,435,035...62,438,354
Ensembl chr13:62,434,422...62,438,354

G

macrophage receptor with collagenous structure

disease_progression

association with Cryptococcal neoformans infection.

NCBI chr19:30,996,209...31,034,520
Ensembl chr19:30,996,347...31,034,487

bacterial pneumonia

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

ATP binding cassette subfamily C member 1

NCBI chr 6:27,855,702...27,950,140
Ensembl chr 6:27,855,702...27,989,331

G

angiotensin converting enzyme 2

associated with Pseudomonas Infections;mRNA, protein:altered expression, altered activity:lung (mouse)

NCBI chr X:11,798,839...11,839,591
Ensembl chr X:11,798,839...11,900,594

G

advanced glycosylation end-product specific receptor

severity

NCBI chr12:1,574,251...1,577,410
Ensembl chr12:1,574,251...1,577,129

G

B9 domain containing 2

severity

NCBI chr 1:112,621,832...112,627,726
Ensembl chr 1:112,621,633...112,643,885

G

complement C3

NCBI chr20:53,566,226...53,598,365
Ensembl chr20:53,566,261...53,598,761

G

complement C3a receptor 1

NCBI chr27:37,431,745...37,439,858
Ensembl chr27:37,433,792...37,435,246

G

complement C5

NCBI chr11:73,953,727...74,029,919
Ensembl chr11:73,953,727...74,029,851

G

catalase

protein:decreased expression:lung, plasma

NCBI chr18:33,383,005...33,422,447
Ensembl chr18:33,383,005...33,422,447

G

C-C motif chemokine ligand 19

mRNA, protein:increased expression:lung

NCBI chr11:51,357,706...51,359,207
Ensembl chr11:51,340,530...51,359,365

G

C-C motif chemokine ligand 2

NCBI chr 9:39,008,187...39,009,932

G

chemokine (C-C motif) ligand 4

NCBI chr 9:37,681,342...37,682,691
Ensembl chr 9:37,676,966...37,710,209

G

C-C motif chemokine receptor 2

NCBI chr20:42,305,344...42,313,258
Ensembl chr20:42,307,580...42,308,698

G

C-C motif chemokine receptor 7

NCBI chr 9:22,077,976...22,092,818
Ensembl chr 9:22,068,775...22,090,656

G

CD14 molecule

NCBI chr 2:35,790,505...35,792,967

G

CD40 molecule

NCBI chr24:33,352,992...33,383,488
Ensembl chr24:33,372,930...33,383,301

G

CD80 molecule

NCBI chr33:23,177,136...23,208,421
Ensembl chr33:23,177,138...23,201,380

G

component of inhibitor of nuclear factor kappa B kinase complex

NCBI chr28:12,964,670...13,001,557
Ensembl chr28:12,965,479...13,001,512

G

colony stimulating factor 3

disease_progression
treatment

associated with Peritonitis;

PMID:12352049 PMID:21373266

RGD:11039437 RGD:5133733

NCBI chr 9:22,529,643...22,532,326
Ensembl chr 9:22,530,698...22,533,108

G

colony stimulating factor 3 receptor

disease_progression

NCBI chr15:5,818,985...5,832,455
Ensembl chr15:5,822,025...5,831,882

G

C-X-C motif chemokine ligand 10

severity

PMID:15618188 PMID:16299319

RGD:5135458 RGD:5135459

NCBI chr32:598,406...599,925
Ensembl chr32:597,987...599,979

G

C-X-C motif chemokine ligand 11

NCBI chr32:631,084...636,997
Ensembl chr32:631,478...632,868
Ensembl chr32:631,478...632,868

G

C-X-C motif chemokine receptor 3

NCBI chr X:55,882,433...55,884,582
Ensembl chr X:55,882,433...55,884,582

G

cytochrome P450 family 2 subfamily J member 2

protein:decreased expression:lung

NCBI chr 5:49,942,241...49,986,603
Ensembl chr 5:49,942,193...49,984,617

G

defensin, beta 4A

protein:increased expression:plasma

NCBI chr16:58,953,916...58,956,407
Ensembl chr16:58,953,916...58,956,407

G

coagulation factor II, thrombin

protein:increased expression:lung

NCBI chr18:42,782,744...42,799,531
Ensembl chr18:42,782,751...42,799,459

G

forkhead box P3

severity

NCBI chr X:42,331,229...42,362,841
Ensembl chr X:42,344,108...42,350,758

G

glycoprotein Ib platelet subunit alpha

exacerbates

associated with Escherichia Coli Infections

NCBI chr 5:31,681,605...31,683,261

G

G protein-coupled receptor kinase 2

mRNA:decreased expression:polymorphonuclear leukocyte

NCBI chr18:50,148,566...50,167,422
Ensembl chr18:50,148,598...50,167,428

G

intercellular adhesion molecule 1

protein:increased expression:lung (mouse)

NCBI chr20:50,818,715...50,827,914
Ensembl chr20:50,818,715...50,827,914

G

interferon alpha and beta receptor subunit 1

severity

NCBI chr31:28,854,765...28,876,399

G

interferon gamma

severity

NCBI chr10:10,406,866...10,411,698
Ensembl chr10:10,406,867...10,411,698

G

interleukin 10

severity

NCBI chr 7:5,933,285...5,937,057
Ensembl chr 7:5,933,285...5,937,057

G

interleukin 15

NCBI chr19:1,339,607...1,364,762
Ensembl chr19:1,339,967...1,364,762

G

interleukin 17A

severity

PMID:18802100 PMID:25398094

RGD:38501102 RGD:4889153

NCBI chr12:19,854,129...19,862,521
Ensembl chr12:19,854,129...19,862,513

G

interleukin 18

NCBI chr 5:20,972,742...20,995,327
Ensembl chr 5:20,972,871...20,995,348

G

interleukin 1 beta

treatment
severity

associated with Agranulocytosis

PMID:7546648 PMID:18596024 PMID:25398094

RGD:10755357 RGD:38501102 RGD:4143205

NCBI chr17:37,019,329...37,033,388
Ensembl chr17:37,019,329...37,024,458

G

interleukin 1 receptor like 1

treatment

associated with Sepsis
associated with Acinetobacter infectious disease

PMID:20959556 PMID:29508184

RGD:40818077 RGD:5144223

NCBI chr10:40,658,191...40,732,097
Ensembl chr10:40,659,041...40,677,357

G

interleukin 1 receptor antagonist

PMID:18322242 PMID:18596024

RGD:4143205 RGD:4143206

NCBI chr17:37,236,690...37,250,424
Ensembl chr17:37,212,751...37,249,329

G

interleukin 6

severity

NCBI chr14:36,474,268...36,478,519
Ensembl chr14:36,473,394...36,478,519

G

interleukin 1 receptor associated kinase 3

PMID:20439918 PMID:28120642

RGD:34888234 RGD:36049799

NCBI chr10:8,683,541...8,730,757
Ensembl chr10:8,684,242...8,729,268

G

interferon regulatory factor 1

NCBI chr11:20,773,801...20,781,106
Ensembl chr11:20,760,120...20,781,608

G

interferon regulatory factor 3

NCBI chr 1:106,875,016...106,879,065
Ensembl chr 1:106,875,118...106,879,065

G

integrin subunit beta 3

protein:increased expression:lung, neutrophil

NCBI chr 9:9,179,667...9,231,061
Ensembl chr 9:9,182,562...9,231,451

G

leptin

NCBI chr14:8,115,396...8,130,946
Ensembl chr14:8,116,122...8,131,395

G

pulmonary surfactant-associated protein A-like

protein:increased expression:lung

NCBI chr 4:29,430,139...29,434,640

G

mitogen-activated protein kinase 8

severity

associated with Escherichia Coli Infections

NCBI chr28:323,361...410,367
Ensembl chr28:368,513...406,401

G

mannose binding lectin 1

Legionella Pneumonia; DNA:mutations:5' utr, exon:multiple (human)

NCBI chr 4:29,419,886...29,424,377

G

melanocortin 1 receptor

NCBI chr 5:63,694,296...63,695,249

G

matrix metallopeptidase 9

protein:increased expression:bronchoalveolar lavage fluid

PMID:17202364 PMID:19535150

RGD:5129533 RGD:5130727

NCBI chr24:33,274,260...33,281,116
Ensembl chr24:33,274,268...33,281,293

G

myeloperoxidase

protein:increased activity:bronchoalveolar lavage Fluid:

NCBI chr 9:32,927,483...32,938,007
Ensembl chr 9:32,927,483...32,937,820

G

nucleotide binding oligomerization domain containing 1

NCBI chr14:43,162,671...43,226,948
Ensembl chr14:43,163,571...43,227,103

G

nucleotide binding oligomerization domain containing 2

NCBI chr 2:64,636,850...64,667,232
Ensembl chr 2:64,635,519...64,667,232

G

podoplanin

protein:increased expression:lung

NCBI chr 2:83,552,735...83,581,375
Ensembl chr 2:83,552,830...83,581,375

G

platelet and endothelial cell adhesion molecule 1

protein:decreased expression:lung

NCBI chr 9:12,166,124...12,219,553
Ensembl chr 9:12,166,775...12,219,778

G

placental growth factor

protein:increased expression:plasma

NCBI chr 8:48,059,554...48,110,534
Ensembl chr 8:48,059,552...48,075,170

G

phosphatase and tensin homolog

ameliorates

myeloid knockout

NCBI chr26:37,853,148...37,913,176
Ensembl chr26:37,835,661...37,913,176

G

receptor interacting serine/threonine kinase 3

ameliorates

NCBI chr 8:4,304,167...4,309,514
Ensembl chr 8:4,305,250...4,309,325

G

RAR related orphan receptor C

severity

NCBI chr17:60,821,498...60,842,485
Ensembl chr17:60,821,981...60,842,453

G

serpin family E member 1

severity

NCBI chr 6:8,719,547...8,727,160
Ensembl chr 6:8,720,825...8,726,301

G

surfactant protein B

associated with Cystic Fibrosis;protein:increased expression:lung

PMID:12169586 PMID:15271694

RGD:4143403 RGD:4143464

NCBI chr17:39,419,305...39,428,513
Ensembl chr17:39,386,584...39,426,229

G

surfactant protein C

PMID:12169586 PMID:18566429

RGD:4143464 RGD:4144114

NCBI chr25:35,088,295...35,090,995
Ensembl chr25:35,088,279...35,091,457

G

surfactant protein D

associated with Cystic Fibrosis;protein:decreased expression:lung
protein:increased expression:lung

PMID:12169586 PMID:15271694

RGD:4143403 RGD:4143464

NCBI chr 4:29,394,755...29,407,499
Ensembl chr 4:29,394,678...29,407,293

G

signal transducer and activator of transcription 3

NCBI chr 9:20,539,660...20,614,631
Ensembl chr 9:20,539,697...20,612,672

G

toll like receptor 2

PMID:18768871 PMID:19844782

RGD:4145337 RGD:4889533

NCBI chr15:51,454,557...51,465,429
Ensembl chr15:51,454,695...51,465,241

G

toll like receptor 4

PMID:16210672 PMID:20650991

RGD:4144172 RGD:4144197

NCBI chr11:71,356,390...71,367,166
Ensembl chr11:71,356,390...71,367,165

G

toll like receptor 5

NCBI chr38:23,700,323...23,705,628
Ensembl chr38:23,702,033...23,705,314

G

toll like receptor 6

NCBI chr 3:73,504,357...73,523,964
Ensembl chr 3:73,520,706...73,523,099

G

toll like receptor 9

NCBI chr20:37,529,322...37,547,117
Ensembl chr20:37,542,340...37,547,114
Ensembl chr20:37,542,340...37,547,114

G

tumor necrosis factor

disease_progression
severity
treatment

associated with Agranulocytosis

PMID:7546648 PMID:9310939 PMID:10650487 PMID:12958055

RGD:10449451 RGD:10450564 RGD:10755357 RGD:4143476

NCBI chr12:1,074,561...1,076,425
Ensembl chr12:1,074,552...1,076,425

G

TNF receptor superfamily member 1A

protein:increased expression:serum (mouse)

NCBI chr27:38,641,837...38,654,693
Ensembl chr27:38,638,753...38,700,282

G

TNF receptor superfamily member 1B

protein:increased expression:serum (mouse)

NCBI chr 2:84,140,179...84,151,219
Ensembl chr 2:84,141,911...84,157,191

G

triggering receptor expressed on myeloid cells 1

severity
ameliorates

PMID:16960786 PMID:22996209 PMID:24465168

RGD:126848796 RGD:126925987 RGD:127229902

NCBI chr12:9,990,678...10,000,195
Ensembl chr12:9,990,679...10,000,236

G

zinc finger CCCH-type containing 12A

associated with Pseudomonas Infections

NCBI chr15:4,972,369...4,984,218
Ensembl chr15:4,972,956...4,980,371

bronchiolitis

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

adrenoceptor beta 2

NCBI chr 4:60,048,502...60,050,447
Ensembl chr 4:59,941,517...60,050,298

G

CD40 molecule

NCBI chr24:33,352,992...33,383,488
Ensembl chr24:33,372,930...33,383,301

G

CD86 molecule

protein:decreased expression:myeloid dendritic cell (mouse)

NCBI chr33:25,256,267...25,318,855
Ensembl chr33:25,256,267...25,318,087

G

C-reactive protein

severity

NCBI chr38:22,396,787...22,398,180
Ensembl chr38:22,396,263...22,399,166

G

cysteinyl leukotriene receptor 1

associated with Pneumovirus Infections

NCBI chr X:60,462,290...60,513,155
Ensembl chr X:60,463,526...60,464,548

G

interleukin 17A

susceptibility

DNA:SNP:promoter:rs2275913 (human)

NCBI chr12:19,854,129...19,862,521
Ensembl chr12:19,854,129...19,862,513

G

interleukin 1 beta

protein:increased expression:lung

NCBI chr17:37,019,329...37,033,388
Ensembl chr17:37,019,329...37,024,458

G

interleukin 1 receptor antagonist

protein:increased expression:lung

NCBI chr17:37,236,690...37,250,424
Ensembl chr17:37,212,751...37,249,329

G

mucin 5B, oligomeric mucus/gel-forming

DNA:polymorphisms:promoter:rs885454,rs17235353, rs7115457 (human)

NCBI chr18:45,517,479...45,545,765
Ensembl chr18:45,517,474...45,545,184

bronchiolitis obliterans

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

angiotensin I converting enzyme

NCBI chr 9:11,497,182...11,516,362
Ensembl chr 9:11,497,182...11,516,358

G

adenosine A2a receptor

NCBI chr26:28,141,076...28,150,600
Ensembl chr26:28,141,076...28,150,598

G

C-C motif chemokine ligand 17

NCBI chr 2:59,001,463...59,014,347
Ensembl chr 2:59,001,464...59,005,230

G

C-C motif chemokine ligand 2

NCBI chr 9:39,008,187...39,009,932

G

C-C motif chemokine ligand 22

NCBI chr 2:59,039,650...59,045,519
Ensembl chr 2:59,040,539...59,045,625

G

C-C motif chemokine ligand 5

mRNA:increased expression:lung (rat)

PMID:14611812 PMID:19840961

RGD:2307195 RGD:4889978

NCBI chr 9:37,817,409...37,823,852
Ensembl chr 9:37,817,305...37,823,852

G

C-C motif chemokine ligand 7

protein:increased expression:bronchoalveolar Lavage fluid

NCBI chr 9:38,994,638...38,996,103
Ensembl chr 9:38,993,911...39,010,483

G

C-C motif chemokine receptor 2

mRNA:increased expression:trachea:

NCBI chr20:42,305,344...42,313,258
Ensembl chr20:42,307,580...42,308,698

G

CD86 molecule

NCBI chr33:25,256,267...25,318,855
Ensembl chr33:25,256,267...25,318,087

G

colony stimulating factor 2

associated with Respiratory Aspiration;protein:increased expression:serum

NCBI chr11:20,342,880...20,346,959
Ensembl chr11:20,344,648...20,346,959

G

C-X-C motif chemokine ligand 10

protein:increased expression:respiratory system fluid/secretion

PMID:12097412 PMID:16709871

RGD:5135441 RGD:5135451

NCBI chr32:598,406...599,925
Ensembl chr32:597,987...599,979

G

C-X-C motif chemokine ligand 11

protein:increased expression:respiratory system fluid/secretion

NCBI chr32:631,084...636,997
Ensembl chr32:631,478...632,868
Ensembl chr32:631,478...632,868

G

C-X-C motif chemokine receptor 3

PMID:12097412 PMID:16709871

RGD:5135441 RGD:5135451

NCBI chr X:55,882,433...55,884,582
Ensembl chr X:55,882,433...55,884,582

G

endothelin 1

human gene in a rat model

NCBI chr35:11,808,892...11,815,383
Ensembl chr35:11,808,892...11,815,383

G

forkhead box P3

mRNA:increased expression:lung

NCBI chr X:42,331,229...42,362,841
Ensembl chr X:42,344,108...42,350,758

G

granzyme B

NCBI chr 8:4,508,718...4,511,824
Ensembl chr 8:4,470,577...4,512,628

G

heme oxygenase 1

NCBI chr10:28,744,404...28,751,544
Ensembl chr10:28,743,795...28,751,773

G

interferon gamma

CTD Direct Evidence: therapeutic

NCBI chr10:10,406,866...10,411,698
Ensembl chr10:10,406,867...10,411,698

G

interleukin 13

protein:increased expression:bronchoalveolar lavage fluid

NCBI chr11:20,957,870...20,961,391
Ensembl chr11:20,958,464...20,961,388

G

interleukin 13 receptor subunit alpha 1

NCBI chr X:90,925,497...90,981,855
Ensembl chr X:90,924,801...90,979,963

G

interleukin 13 receptor subunit alpha 2

NCBI chr X:87,747,373...87,776,797
Ensembl chr X:87,747,373...87,776,798

G

interleukin 17A

mRNA:increased expression:trachea

NCBI chr12:19,854,129...19,862,521
Ensembl chr12:19,854,129...19,862,513

G

interleukin 1 receptor antagonist

protein:increased expression:lung

NCBI chr17:37,236,690...37,250,424
Ensembl chr17:37,212,751...37,249,329

G

interleukin 4

protein:increased expression:serum

NCBI chr11:20,972,693...20,981,539
Ensembl chr11:20,972,690...20,981,534

G

interleukin 6

NCBI chr14:36,474,268...36,478,519
Ensembl chr14:36,473,394...36,478,519

G

mannose binding lectin 1

resistance

DNA:transversion:5' utr:-290C>G rs7096206 (human)

NCBI chr 4:29,419,886...29,424,377

G

matrix metallopeptidase 9

protein:increased expression, increased activity:bronchoalveolar lavage fluid

NCBI chr24:33,274,260...33,281,116
Ensembl chr24:33,274,268...33,281,293

G

mucin 1, cell surface associated

protein:increased expression:serum

NCBI chr 7:42,338,939...42,344,690
Ensembl chr 7:42,340,375...42,344,690

G

nucleotide binding oligomerization domain containing 2

NCBI chr 2:64,636,850...64,667,232
Ensembl chr 2:64,635,519...64,667,232

G

nitric oxide synthase 2

associated with lung transplantation; protein:increased expression:lung

NCBI chr 9:42,171,821...42,210,217
Ensembl chr 9:42,171,821...42,208,588

G

nitric oxide synthase 3

protein:increased expression:lung

NCBI chr16:15,054,196...15,072,454
Ensembl chr16:15,011,344...15,072,277

G

secretoglobin family 1A member 1

associated with lung transplantation; protein:decreased expression:serum,bronchoalveolar lavage

NCBI chr18:54,187,487...54,191,493
Ensembl chr18:54,187,487...54,191,482

G

surfactant protein D

NCBI chr 4:29,394,755...29,407,499
Ensembl chr 4:29,394,678...29,407,293

G

toll like receptor 9

DNA:SNPs:promoter, 3' utr:g.-1485C>T (rs187084), rs352162 (human)

NCBI chr20:37,529,322...37,547,117
Ensembl chr20:37,542,340...37,547,114
Ensembl chr20:37,542,340...37,547,114

bronchitis

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

cytochrome P450 family 1 subfamily A member 1

DNA:polymorphism (human)

NCBI chr30:37,793,277...37,799,535
Ensembl chr30:37,793,508...37,796,866

G

early growth response 1

NCBI chr11:26,046,195...26,049,806
Ensembl chr11:26,046,228...26,048,575

G

histone deacetylase 2

treatment

NCBI chr12:70,053,822...70,083,491
Ensembl chr12:70,053,297...70,103,578

G

interferon gamma

resistance

NCBI chr10:10,406,866...10,411,698
Ensembl chr10:10,406,867...10,411,698

bronchopneumonia

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

C-C motif chemokine ligand 5

protein:increased secretion:serum (human)

NCBI chr 9:37,817,409...37,823,852
Ensembl chr 9:37,817,305...37,823,852

G

C-X-C motif chemokine receptor 2

disease_progression

associated with Plague

NCBI chr37:24,831,351...24,846,387
Ensembl chr37:24,843,171...24,844,247

G

mannose binding lectin 1

associated with Down Syndrome; protein:decreased secretion:serum (human)

NCBI chr 4:29,419,886...29,424,377

Chlamydia pneumonia

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

CD274 molecule

mRNA:increased expression:lung

NCBI chr 1:93,461,735...93,605,772
Ensembl chr 1:93,585,518...93,603,522

G

programmed cell death 1

mRNA:increased expression:lung

NCBI chr25:51,606,559...51,618,903
Ensembl chr25:51,608,173...51,618,723

G

phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit delta

severity

NCBI chr 5:62,884,596...62,936,882
Ensembl chr 5:62,909,009...62,935,971

Chronic Bronchitis

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

CF transmembrane conductance regulator

susceptibility

associated with pulmonary disease chronic obstructive; DNA:missense mutation:exon:p.R75Q(human)
DNA:deletion: :F508del(human)

PMID:10767489 PMID:15463907

RGD:4140475 RGD:4140484

NCBI chr14:56,290,417...56,452,919
Ensembl chr14:56,290,275...56,453,977

G

cytotoxic T-lymphocyte associated protein 4

DNA:SNPs: :multiple (human)

NCBI chr37:12,647,712...12,653,874
Ensembl chr37:12,634,563...12,653,874

G

cytochrome P450 family 1 subfamily A member 1

susceptibility

DNA:polymorphism (human)

NCBI chr30:37,793,277...37,799,535
Ensembl chr30:37,793,508...37,796,866

G

cytochrome P450 family 2 subfamily E member 1

DNA:polymorphism (human)

NCBI chr28:41,079,164...41,089,188
Ensembl chr28:41,035,025...41,122,754

G

endothelin 1

Chronic Allergic Airway Inflammation; protein:increased secretion:bronchoalveolar lavage (mouse)

NCBI chr35:11,808,892...11,815,383
Ensembl chr35:11,808,892...11,815,383

G

GC vitamin D binding protein

susceptibility

NCBI chr13:60,795,305...60,828,038
Ensembl chr13:60,795,305...60,827,929

G

intercellular adhesion molecule 1

protein:increased expression:bronchial epithelium (rat)

NCBI chr20:50,818,715...50,827,914
Ensembl chr20:50,818,715...50,827,914

G

interleukin 10

protein:decreased expression:lung

NCBI chr 7:5,933,285...5,937,057
Ensembl chr 7:5,933,285...5,937,057

G

interleukin 13

protein:increased expression:Respiratory Mucosa

NCBI chr11:20,957,870...20,961,391
Ensembl chr11:20,958,464...20,961,388

G

interleukin 15

mRNA, protein:increased expression:lung

NCBI chr19:1,339,607...1,364,762
Ensembl chr19:1,339,967...1,364,762

G

myeloperoxidase

protein:increased expression:lung

NCBI chr 9:32,927,483...32,938,007
Ensembl chr 9:32,927,483...32,937,820

G

nitric oxide synthase 2

NCBI chr 9:42,171,821...42,210,217
Ensembl chr 9:42,171,821...42,208,588

G

neuropeptide Y

CTD Direct Evidence: marker/mechanism

NCBI chr14:37,824,579...37,831,289
Ensembl chr14:37,823,861...37,831,443

G

vascular endothelial growth factor A

CTD Direct Evidence: marker/mechanism

NCBI chr12:12,209,032...12,224,978
Ensembl chr12:12,208,231...12,224,965

chronic rhinitis

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

endothelin 1

protein:increased expression:inferior turbinate, nasal gland, inflammatory cell (human)

NCBI chr35:11,808,892...11,815,383
Ensembl chr35:11,808,892...11,815,383

Chronic Rhinosinusitis

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

CD8 subunit alpha

ameliorates

protein:decreased expression:blood, T cell (human)

NCBI chr17:38,396,022...38,400,508
Ensembl chr17:38,369,414...38,400,508

G

interleukin 17A

protein:increased expression:uncinate process, nasal mucosa (human)

NCBI chr12:19,854,129...19,862,521
Ensembl chr12:19,854,129...19,862,513

G

interleukin 1 receptor antagonist

susceptibility

DNA:repeats:intron:IVS2+914_1000dup I/II alleles (human)

NCBI chr17:37,236,690...37,250,424
Ensembl chr17:37,212,751...37,249,329

G

bone marrow proteoglycan-like

disease_progression

associated with Nasal Polyps;

NCBI chr18:38,753,269...38,760,730

G

mannose binding lectin 1

protein:decreased activity:serum:

NCBI chr 4:29,419,886...29,424,377

common cold

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

arachidonate 5-lipoxygenase

protein:increased expression:bronchus

NCBI chr28:2,170,920...2,218,765
Ensembl chr28:2,170,920...2,219,609

G

arachidonate 5-lipoxygenase activating protein

protein:increased expression:bronchus

NCBI chr25:9,320,868...9,351,056
Ensembl chr25:9,320,864...9,351,836

G

C-X3-C motif chemokine ligand 1

NCBI chr 2:59,022,794...59,032,095
Ensembl chr 2:59,022,794...59,032,095

G

C-X-C motif chemokine ligand 10

protein:increased expression:respiratory system fluid/secretion

NCBI chr32:598,406...599,925
Ensembl chr32:597,987...599,979

G

C-X-C motif chemokine ligand 8

treatment

NCBI chr13:62,435,035...62,438,354
Ensembl chr13:62,434,422...62,438,354

G

C-X-C motif chemokine receptor 2

NCBI chr37:24,831,351...24,846,387
Ensembl chr37:24,843,171...24,844,247

G

defensin, beta 4A

mRNA, protein:increased expression:nasal cavity epithelium, nasal mucus

NCBI chr16:58,953,916...58,956,407
Ensembl chr16:58,953,916...58,956,407

G

interleukin 10

NCBI chr 7:5,933,285...5,937,057
Ensembl chr 7:5,933,285...5,937,057

G

interleukin 1 alpha

protein:increased expression:nasal mucus

NCBI chr17:36,969,581...36,979,445
Ensembl chr17:36,970,573...36,979,435

G

interleukin 1 beta

protein:increased expression:nasal mucus

NCBI chr17:37,019,329...37,033,388
Ensembl chr17:37,019,329...37,024,458

G

interleukin 1 receptor antagonist

protein:increased expression:nasal mucus

PMID:10358201 PMID:18279051

RGD:4143183 RGD:4143207

NCBI chr17:37,236,690...37,250,424
Ensembl chr17:37,212,751...37,249,329

G

interleukin 33

protein:increased expression:nasal mucus

NCBI chr11:27,219,878...27,256,723
Ensembl chr11:27,219,878...27,256,721

G

interleukin 4

associated with Asthma;mRNA, protein:increased expression:alveolar macrophage, respiratory system fluid/secretion

NCBI chr11:20,972,693...20,981,539
Ensembl chr11:20,972,690...20,981,534

G

alveolar macrophage chemotactic factor-like

associated with Asthma

NCBI chr13:62,514,244...62,516,439
Ensembl chr13:62,513,898...62,515,218

G

peroxiredoxin 5

associated with asthma;protein:increased expression:sputum (human)

NCBI chr18:52,750,977...52,754,432

G

thymic stromal lymphopoietin

protein:increased expression:nasal mucus (human)

NCBI chr 3:1,502,469...1,507,696
Ensembl chr 3:1,503,188...1,507,696

cryptogenic organizing pneumonia

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

TNF receptor superfamily member 1A

protein:increased expression:lung, macrophage (human)

NCBI chr27:38,641,837...38,654,693
Ensembl chr27:38,638,753...38,700,282

G

TNF receptor superfamily member 1B

protein:increased expression:lung, lymphocyte (human)

NCBI chr 2:84,140,179...84,151,219
Ensembl chr 2:84,141,911...84,157,191

desquamative interstitial pneumonia

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

surfactant protein C

OMIM:263000

NCBI chr25:35,088,295...35,090,995
Ensembl chr25:35,088,279...35,091,457

Diffuse Panbronchiolitis

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

MHC class I DLA-88

susceptibility

DNA:polymorphism:cds:HLA-B*5401 (human)

NCBI chr12:892,442...895,691
Ensembl chr12:892,388...1,021,690

G

mannose binding lectin 1

susceptibility

DNA:SNP:exon:p.G54D(rs1800450)(human)

NCBI chr 4:29,419,886...29,424,377

G

mucin 5AC, oligomeric mucus/gel-forming

protein:decreased expression:bronchiole epithelium

NCBI chr18:45,471,232...45,498,961

G

mucin 5B, oligomeric mucus/gel-forming

DNA:insertion/deletion

NCBI chr18:45,517,479...45,545,765
Ensembl chr18:45,517,474...45,545,184

G

mucin like 3

CTD Direct Evidence: marker/mechanism

NCBI chr12:700,313...715,625

G

transporter 2, ATP binding cassette subfamily B member

susceptibility

DNA:polymorphisms:exon:

NCBI chr12:2,407,512...2,417,469
Ensembl chr12:2,378,126...2,432,303

ethmoid sinusitis

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

C-C motif chemokine ligand 7

protein:increased expression:ethmoid sinus

NCBI chr 9:38,994,638...38,996,103
Ensembl chr 9:38,993,911...39,010,483

Fungal Lung Diseases

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

complement C5

NCBI chr11:73,953,727...74,029,919
Ensembl chr11:73,953,727...74,029,851

G

C-C motif chemokine ligand 7

NCBI chr 9:38,994,638...38,996,103
Ensembl chr 9:38,993,911...39,010,483

G

GATA binding protein 2

associated with Pneumocystis Infections

NCBI chr20:2,472,251...2,488,380
Ensembl chr20:2,473,912...2,480,991

G

interleukin 13

protein:increased expression:lung

PMID:16544260 PMID:19752036

RGD:4145474 RGD:4145506

NCBI chr11:20,957,870...20,961,391
Ensembl chr11:20,958,464...20,961,388

G

interleukin 33

protein:increased expression:lung

NCBI chr11:27,219,878...27,256,723
Ensembl chr11:27,219,878...27,256,721

G

pulmonary surfactant-associated protein A-like

susceptibility

NCBI chr 4:29,430,139...29,434,640

G

nitric oxide synthase 2

protein:decreased expression:lung

NCBI chr 9:42,171,821...42,210,217
Ensembl chr 9:42,171,821...42,208,588

G

surfactant protein D

susceptibility

NCBI chr 4:29,394,755...29,407,499
Ensembl chr 4:29,394,678...29,407,293

G

tumor necrosis factor

protein:increased expression:lung

NCBI chr12:1,074,561...1,076,425
Ensembl chr12:1,074,552...1,076,425

Human Influenza

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

ABO, alpha 1-3-N-acetylgalactosaminyltransferase and alpha 1-3-galactosyltransferase

susceptibility

DNA:polymorphism:cds:allele AB (human)

PMID:4375858 PMID:6189297

RGD:39938844 RGD:5128836

NCBI chr 9:49,746,749...49,758,317
Ensembl chr 9:49,748,693...49,758,479

G

apolipoprotein L6

CTD Direct Evidence: marker/mechanism

NCBI chr10:28,536,085...28,556,766
Ensembl chr10:28,534,428...28,548,423

G

activating transcription factor 3

CTD Direct Evidence: marker/mechanism

NCBI chr 7:10,784,445...10,795,285
Ensembl chr 7:10,782,064...10,794,163

G

complement C3

NCBI chr20:53,566,226...53,598,365
Ensembl chr20:53,566,261...53,598,761

G

catalase

PMID:16804020 PMID:19959187 PMID:20653246

RGD:5130201 RGD:5130744 RGD:5130864

NCBI chr18:33,383,005...33,422,447
Ensembl chr18:33,383,005...33,422,447

G

C-C motif chemokine ligand 2

CTD Direct Evidence: marker/mechanism
mRNA:increased expression:lung

PMID:20967263 PMID:23326326

NCBI chr 9:39,008,187...39,009,932

G

C-C motif chemokine ligand 28

resistance

NCBI chr 4:66,567,139...66,597,310
Ensembl chr 4:66,566,989...66,597,459

G

C-C motif chemokine ligand 5

susceptibility

protein:increased expression:lung (mouse)

PMID:16208318 PMID:20656925

RGD:4145452 RGD:4892131

NCBI chr 9:37,817,409...37,823,852
Ensembl chr 9:37,817,305...37,823,852

G

C-C motif chemokine ligand 8

CTD Direct Evidence: marker/mechanism

NCBI chr 9:38,949,184...38,950,702
Ensembl chr 9:38,948,184...38,950,803

G

C-C motif chemokine receptor 5

severity

DNA:frameshift mutation:cds:p.S185_T195del rs333 (human)

PMID:18617426 PMID:19039768 PMID:20875295

RGD:4892063 RGD:4892119 RGD:4892122

NCBI chr20:42,293,288...42,297,952
Ensembl chr20:42,294,996...42,297,952

G

CD14 molecule

NCBI chr 2:35,790,505...35,792,967

G

CD209 molecule

susceptibility

NCBI chr20:52,517,759...52,542,085
Ensembl chr20:52,518,036...52,520,942

G

CD28 molecule

NCBI chr37:12,503,849...12,536,362
Ensembl chr37:12,503,811...12,532,854

G

CD40 molecule

NCBI chr24:33,352,992...33,383,488
Ensembl chr24:33,372,930...33,383,301

G

CD80 molecule

PMID:10604996 PMID:19922665

RGD:5132270 RGD:5132623

NCBI chr33:23,177,136...23,208,421
Ensembl chr33:23,177,138...23,201,380

G

CD86 molecule

protein:increased expression:mediastinal lymph node, B cell (mouse)

NCBI chr33:25,256,267...25,318,855
Ensembl chr33:25,256,267...25,318,087

G

C-reactive protein

protein:increased expression:serum

NCBI chr38:22,396,787...22,398,180
Ensembl chr38:22,396,263...22,399,166

G

colony stimulating factor 2

PMID:20427198 PMID:21474645

RGD:5131470 RGD:5131472

NCBI chr11:20,342,880...20,346,959
Ensembl chr11:20,344,648...20,346,959

G

C-X-C motif chemokine ligand 10

CTD Direct Evidence: marker/mechanism

NCBI chr32:598,406...599,925
Ensembl chr32:597,987...599,979

G

DExD/H-box helicase 60

CTD Direct Evidence: marker/mechanism

NCBI chr15:63,649,441...63,741,357
Ensembl chr15:63,649,875...63,734,920

G

MHC class II DLA DRB1 beta chain

NCBI chr12:2,151,409...2,164,564

G

early growth response 1

mRNA:increased expression:frontal cortex (mouse)

NCBI chr11:26,046,195...26,049,806
Ensembl chr11:26,046,228...26,048,575

G

eukaryotic translation initiation factor 2 alpha kinase 2

CTD Direct Evidence: marker/mechanism

NCBI chr17:29,494,641...29,537,933
Ensembl chr17:29,496,128...29,537,933

G

forkhead box P2

NCBI chr14:53,311,214...53,864,056
Ensembl chr14:53,312,045...53,862,655

G

guanylate binding protein 1

CTD Direct Evidence: marker/mechanism

NCBI chr 6:59,378,069...59,393,388
Ensembl chr 6:59,273,592...59,393,229

G

HECT and RLD domain containing E3 ubiquitin protein ligase 5

CTD Direct Evidence: marker/mechanism

NCBI chr32:11,756,487...11,800,695

G

HECT and RLD domain containing E3 ubiquitin protein ligase family member 6

CTD Direct Evidence: marker/mechanism

NCBI chr32:11,624,883...11,751,305
Ensembl chr32:11,694,963...11,750,719

G

interferon induced protein 35

CTD Direct Evidence: marker/mechanism

NCBI chr 9:20,050,438...20,061,346
Ensembl chr 9:20,050,438...20,061,319

G

interferon induced protein 44

CTD Direct Evidence: marker/mechanism

NCBI chr 6:68,361,724...68,377,991
Ensembl chr 6:68,364,494...68,377,876

G

interferon induced protein 44 like

CTD Direct Evidence: marker/mechanism

NCBI chr 6:68,382,157...68,400,880
Ensembl chr 6:68,382,317...68,398,053

G

interferon alpha inducible protein 6

CTD Direct Evidence: marker/mechanism

NCBI chr 2:72,638,657...72,642,648
Ensembl chr 2:72,638,705...72,642,648

G

interferon induced with helicase C domain 1

CTD Direct Evidence: marker/mechanism

NCBI chr36:7,668,925...7,727,040
Ensembl chr36:7,649,727...8,261,048

G

interferon induced protein with tetratricopeptide repeats 2

CTD Direct Evidence: marker/mechanism

NCBI chr 4:63,020...71,734
Ensembl chr 4:62,801...69,868

G

interferon induced protein with tetratricopeptide repeats 3

CTD Direct Evidence: marker/mechanism

NCBI chr 4:87,987...105,879
Ensembl chr 4:84,720...117,210

G

interferon induced protein with tetratricopeptide repeats 5

CTD Direct Evidence: marker/mechanism

NCBI chr28:4,318,616...4,329,811
Ensembl chr28:4,318,732...4,328,785

G

interleukin 10

susceptibility

NCBI chr 7:5,933,285...5,937,057
Ensembl chr 7:5,933,285...5,937,057

G

interleukin 12B

NCBI chr 4:51,178,637...51,194,606
Ensembl chr 4:51,183,568...51,193,228

G

interleukin 13

protein:increased expression:serum

NCBI chr11:20,957,870...20,961,391
Ensembl chr11:20,958,464...20,961,388

G

interleukin 15

mRNA, protein:increased expression:lung

PMID:19234203 PMID:20212069 PMID:21098221

RGD:4994196 RGD:4996471 RGD:4996472

NCBI chr19:1,339,607...1,364,762
Ensembl chr19:1,339,967...1,364,762

G

interleukin 15 receptor subunit alpha

NCBI chr 2:29,981,385...30,034,364
Ensembl chr 2:29,981,234...30,038,945

G

interleukin 17A

mRNA, protein:increased expression:lung

PMID:19265125 PMID:19783685

RGD:4889102 RGD:4889150

NCBI chr12:19,854,129...19,862,521
Ensembl chr12:19,854,129...19,862,513

G

interleukin 17 receptor A

NCBI chr27:44,798,960...44,812,287
Ensembl chr27:44,791,066...44,811,064

G

interleukin 18

NCBI chr 5:20,972,742...20,995,327
Ensembl chr 5:20,972,871...20,995,348

G

interleukin 1 alpha

protein:increased expression:lung

NCBI chr17:36,969,581...36,979,445
Ensembl chr17:36,970,573...36,979,435

G

interleukin 1 beta

NCBI chr17:37,019,329...37,033,388
Ensembl chr17:37,019,329...37,024,458

G

interleukin 1 receptor antagonist

disease_progression

protein:increased expression:serum

PMID:9439800 PMID:20840779

RGD:4143203 RGD:4143228

NCBI chr17:37,236,690...37,250,424
Ensembl chr17:37,212,751...37,249,329

G

interleukin 2

protein:increased expression:serum

NCBI chr19:17,750,780...17,756,394
Ensembl chr19:17,750,780...17,756,394

G

interleukin 4

NCBI chr11:20,972,693...20,981,539
Ensembl chr11:20,972,690...20,981,534

G

interleukin 6

NCBI chr14:36,474,268...36,478,519
Ensembl chr14:36,473,394...36,478,519

G

interferon regulatory factor 7

CTD Direct Evidence: marker/mechanism

G

ISG15 ubiquitin like modifier

CTD Direct Evidence: marker/mechanism

NCBI chr 5:56,230,879...56,237,354
Ensembl chr 5:56,236,318...56,404,695

G

lysosomal associated membrane protein 3

CTD Direct Evidence: marker/mechanism

NCBI chr34:16,092,172...16,126,563

G

interferon-induced transmembrane protein 1-like

susceptibility

ClinVar Annotator: match by term: Influenza, severe, susceptibility to

PMID:20943977 PMID:22446628

NCBI chr18:25,484,731...25,485,927

G

interferon-induced protein with tetratricopeptide repeats 1

CTD Direct Evidence: marker/mechanism

NCBI chr 4:125,675...133,304
Ensembl chr 4:84,720...132,981

G

lymphocyte antigen 6 family member E

CTD Direct Evidence: marker/mechanism

NCBI chr13:36,926,776...36,930,265
Ensembl chr13:36,925,980...36,974,979

G

lysosomal trafficking regulator

CTD Direct Evidence: marker/mechanism

NCBI chr 4:4,106,869...4,296,042
Ensembl chr 4:4,089,837...4,294,593

G

matrix metallopeptidase 9

protein:increased activity:lung, heart, brain

NCBI chr24:33,274,260...33,281,116
Ensembl chr24:33,274,268...33,281,293

G

MX dynamin like GTPase 1

CTD Direct Evidence: marker/mechanism

NCBI chr31:35,898,206...35,929,802
Ensembl chr31:35,860,590...35,951,350

G

MX dynamin like GTPase 2

CTD Direct Evidence: marker/mechanism

NCBI chr31:35,860,596...35,883,607
Ensembl chr31:35,860,590...35,951,350

G

nitric oxide synthase 1

protein:increased expression:hippocampus

NCBI chr26:13,787,341...13,895,176
Ensembl chr26:13,786,309...13,962,332

G

nitric oxide synthase 2

mRNA:increased expression:olfactory epithelium
mRNA,protein:increased expression:brain

PMID:17030871 PMID:17674769 PMID:18080188

RGD:4891919 RGD:4891937 RGD:4891952

NCBI chr 9:42,171,821...42,210,217
Ensembl chr 9:42,171,821...42,208,588

G

2'-5'-oligoadenylate synthetase 1

CTD Direct Evidence: marker/mechanism

NCBI chr26:10,385,393...10,396,734
Ensembl chr26:10,385,447...10,396,733

G

2'-5'-oligoadenylate synthetase 2

CTD Direct Evidence: marker/mechanism

NCBI chr26:10,431,881...10,450,085
Ensembl chr26:10,432,042...10,449,009

G

2'-5'-oligoadenylate synthetase 3

CTD Direct Evidence: marker/mechanism

NCBI chr26:10,404,548...10,423,039
Ensembl chr26:10,404,414...10,423,039

G

2'-5'-oligoadenylate synthetase like

CTD Direct Evidence: marker/mechanism

NCBI chr26:16,837,376...16,850,388
Ensembl chr26:16,837,376...16,850,388

G

poly(ADP-ribose) polymerase family member 12

CTD Direct Evidence: marker/mechanism

NCBI chr16:8,828,399...8,867,610
Ensembl chr16:8,828,047...8,866,812

G

phospholipid scramblase 1

CTD Direct Evidence: marker/mechanism

NCBI chr23:41,639,938...41,668,972
Ensembl chr23:41,599,843...41,669,112

G

perforin 1

CTD Direct Evidence: marker/mechanism

NCBI chr 4:21,497,865...21,502,429
Ensembl chr 4:21,498,249...21,500,864

G

prostaglandin-endoperoxide synthase 2

NCBI chr 7:19,668,079...19,674,903
Ensembl chr 7:19,668,082...19,674,903

G

RNA sensor RIG-I

CTD Direct Evidence: marker/mechanism

NCBI chr11:49,764,252...49,799,626
Ensembl chr11:49,764,267...49,799,527

G

radical S-adenosyl methionine domain containing 2

CTD Direct Evidence: marker/mechanism

NCBI chr17:4,488,202...4,508,705
Ensembl chr17:4,487,957...4,507,181

G

receptor transporter protein 4

CTD Direct Evidence: marker/mechanism

NCBI chr34:19,828,751...19,881,672
Ensembl chr34:19,828,988...19,831,943

G

synthesis of cytochrome C oxidase 2

CTD Direct Evidence: marker/mechanism

NCBI chr10:16,783,116...16,790,011
Ensembl chr10:16,788,287...16,790,247

G

serpin family G member 1

CTD Direct Evidence: marker/mechanism

NCBI chr18:38,570,354...38,580,751
Ensembl chr18:38,570,607...38,581,665

G

surfactant protein D

NCBI chr 4:29,394,755...29,407,499
Ensembl chr 4:29,394,678...29,407,293

G

sialic acid binding Ig like lectin 1

CTD Direct Evidence: marker/mechanism

NCBI chr24:17,636,143...17,667,791
Ensembl chr24:17,636,026...17,666,854

G

solute carrier family 22 member 8

CTD Direct Evidence: marker/mechanism

NCBI chr18:53,709,592...53,728,595
Ensembl chr18:53,709,591...53,728,578

G

signal transducer and activator of transcription 1

CTD Direct Evidence: marker/mechanism

NCBI chr37:1,513,438...1,549,837
Ensembl chr37:1,507,219...1,550,178

G

tudor domain containing 7

CTD Direct Evidence: marker/mechanism

NCBI chr11:54,758,092...54,828,766
Ensembl chr11:54,758,826...54,828,743

G

toll like receptor 2

protein:increased expression:monocyte

NCBI chr15:51,454,557...51,465,429
Ensembl chr15:51,454,695...51,465,241

G

toll like receptor 3

mRNA:increased expression:lung (mouse)

PMID:16789835 PMID:18654661

RGD:5129136 RGD:5129219

NCBI chr16:44,617,012...44,633,591
Ensembl chr16:44,550,846...44,653,247

G

transmembrane serine protease 11D

CTD Direct Evidence: marker/mechanism

PMID:20237084 PMID:23072892

NCBI chr13:58,354,360...58,406,229
Ensembl chr13:58,355,829...58,406,622

G

transmembrane serine protease 2

CTD Direct Evidence: marker/mechanism|therapeutic

PMID:20237084 PMID:21123387 PMID:23072892 PMID:26889029 PMID:28778717 More...

NCBI chr31:35,933,082...35,968,732

G

transmembrane serine protease 4

CTD Direct Evidence: marker/mechanism

NCBI chr 5:15,575,068...15,609,819
Ensembl chr 5:15,575,338...15,610,190

G

tumor necrosis factor

protein:increased expression:serum

NCBI chr12:1,074,561...1,076,425
Ensembl chr12:1,074,552...1,076,425

G

TNF alpha induced protein 6

CTD Direct Evidence: marker/mechanism

NCBI chr19:52,607,598...52,623,799
Ensembl chr19:52,607,713...52,623,811

G

TNF receptor superfamily member 1A

protein:increased expression:serum (human)

PMID:17182684 PMID:19497758

RGD:5131157 RGD:5131432

NCBI chr27:38,641,837...38,654,693
Ensembl chr27:38,638,753...38,700,282

G

TNF superfamily member 10

CTD Direct Evidence: marker/mechanism

NCBI chr34:36,719,249...36,734,989
Ensembl chr34:36,670,849...36,735,060

G

torsin family 1 member B

CTD Direct Evidence: marker/mechanism

NCBI chr 9:54,029,849...54,036,032
Ensembl chr 9:54,030,234...54,036,032

G

three prime repair exonuclease 1

CTD Direct Evidence: marker/mechanism

NCBI chr20:40,624,845...40,626,840
Ensembl chr20:40,624,891...40,626,906

G

tripartite motif containing 22

CTD Direct Evidence: marker/mechanism

NCBI chr21:28,677,196...28,696,413
Ensembl chr21:28,682,973...28,695,185

G

ubiquitin conjugating enzyme E2 L6

CTD Direct Evidence: marker/mechanism

NCBI chr18:38,604,172...38,619,118
Ensembl chr18:38,604,198...38,618,993

G

UDP-glucose ceramide glucosyltransferase

CTD Direct Evidence: marker/mechanism

NCBI chr11:66,439,346...66,472,897
Ensembl chr11:66,439,346...66,472,897

G

XIAP associated factor 1

CTD Direct Evidence: marker/mechanism

NCBI chr 5:30,626,356...30,636,731
Ensembl chr 5:30,626,356...30,637,130
Ensembl chr 5:30,626,356...30,637,130

G

zinc finger CCHC-type containing 2

CTD Direct Evidence: marker/mechanism

NCBI chr 1:14,335,727...14,393,157
Ensembl chr 1:14,337,065...14,393,158

idiopathic interstitial pneumonia

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

intercellular adhesion molecule 1

protein:increased expression:lung, alveolar macrophage (human)

NCBI chr20:50,818,715...50,827,914
Ensembl chr20:50,818,715...50,827,914

G

interleukin 6

protein:increased expression:bronchoalveolar lavage (rat)

NCBI chr14:36,474,268...36,478,519
Ensembl chr14:36,473,394...36,478,519

G

kelch like ECH associated protein 1

protein:increased expression:hyperplastic lung epithelium, alveolus (human)

NCBI chr20:50,651,070...50,661,178
Ensembl chr20:50,650,711...50,658,496

G

alveolar macrophage chemotactic factor-like

protein:increased expression:serum
associated with Scleroderma, Diffuse

PMID:16085216 PMID:18432520

RGD:5135258 RGD:5135260

NCBI chr13:62,514,244...62,516,439
Ensembl chr13:62,513,898...62,515,218

G

mechanistic target of rapamycin kinase

NCBI chr 2:84,818,893...84,939,283
Ensembl chr 2:84,787,708...84,939,114

G

secretoglobin family 1A member 1

protein:increased expression:serum

NCBI chr18:54,187,487...54,191,493
Ensembl chr18:54,187,487...54,191,482

G

telomerase reverse transcriptase

ClinVar Annotator: match by term: idiopathic fibrosing alveolitis

PMID:9536098 PMID:15814878 PMID:15885610 PMID:16247010 PMID:17460043 More...

NCBI chr34:11,288,622...11,307,790
Ensembl chr34:11,288,622...11,307,951

influenza A

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

ATM serine/threonine kinase

exacerbates

NCBI chr 5:24,180,129...24,297,207
Ensembl chr 5:24,182,135...24,297,207

G

Bruton tyrosine kinase

ameliorates

Associated with Acute Lung Injury

NCBI chr X:75,270,952...75,302,663
Ensembl chr X:75,270,979...75,302,562

G

dual oxidase 1

protein:decreased expression:blood plasma (human)

NCBI chr30:11,556,024...11,588,203
Ensembl chr30:11,556,024...11,588,202

G

dual oxidase 2

severity

PMID:25751630 PMID:28936773 PMID:29556357

RGD:40924644 RGD:40925921 RGD:40925925

NCBI chr30:11,521,833...11,541,719
Ensembl chr30:11,521,845...11,541,716

G

interferon induced with helicase C domain 1

mRNA:increased expression:nasal cavity mucosa (mouse)

NCBI chr36:7,668,925...7,727,040
Ensembl chr36:7,649,727...8,261,048

G

interleukin 21

NCBI chr19:17,641,833...17,651,275
Ensembl chr19:17,641,833...17,651,266

G

interleukin 27

protein:increased expression:blood serum (human)

NCBI chr 6:18,243,988...18,248,369
Ensembl chr 6:18,244,040...18,247,635

G

interleukin 32

protein:increased expression:blood serum (human)

PMID:18414668 PMID:19291698 PMID:22277801

RGD:150340718 RGD:150340729 RGD:150340751

NCBI chr 6:38,119,287...38,122,979

G

peptidylprolyl isomerase A (cyclophilin A) pseudogene

ameliorates

human gene in a mouse model

NCBI chr 7:80,937,433...80,938,175

G

mitogen-activated protein kinase kinase kinase 8

exacerbates

NCBI chr 2:16,717,845...16,740,816
Ensembl chr 2:16,720,596...16,740,515

G

mitogen-activated protein kinase 8

ameliorates

NCBI chr28:323,361...410,367
Ensembl chr28:368,513...406,401

G

macrophage receptor with collagenous structure

ameliorates

NCBI chr19:30,996,209...31,034,520
Ensembl chr19:30,996,347...31,034,487

G

mitochondrial antiviral signaling protein

disease_progression

NCBI chr24:17,510,209...17,529,286
Ensembl chr24:17,512,761...17,523,807

G

MX dynamin like GTPase 1

ameliorates

human gene in a mouse model

PMID:30945621 PMID:31653718

RGD:126777673 RGD:126777680

NCBI chr31:35,898,206...35,929,802
Ensembl chr31:35,860,590...35,951,350

G

placenta associated 8 B

NCBI chr32:7,004,147...7,049,877
Ensembl chr32:7,007,753...7,029,140

G

RNA sensor RIG-I

mRNA:increased expression:nasal cavity mucosa (mouse)

NCBI chr11:49,764,252...49,799,626
Ensembl chr11:49,764,267...49,799,527

G

receptor interacting serine/threonine kinase 3

exacerbates
susceptibility

PMID:27321907 PMID:28410401 PMID:32200799

RGD:127229911 RGD:127229918 RGD:127229922

NCBI chr 8:4,304,167...4,309,514
Ensembl chr 8:4,305,250...4,309,325

G

serum amyloid A1

protein:increased expression:blood plasma (human)

G

signal transducer and activator of transcription 2

exacerbates

NCBI chr10:641,543...660,882
Ensembl chr10:642,718...658,546

invasive aspergillosis

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

advanced glycosylation end-product specific receptor

NCBI chr12:1,574,251...1,577,410
Ensembl chr12:1,574,251...1,577,129

G

C-C motif chemokine ligand 2

severity

NCBI chr 9:39,008,187...39,009,932

G

C-C motif chemokine ligand 20

protein:increased expression:lung

NCBI chr25:40,506,385...40,509,903
Ensembl chr25:40,506,753...40,509,709

G

C-C motif chemokine receptor 6

disease_progression

NCBI chr 1:54,932,798...54,960,646
Ensembl chr 1:54,932,690...54,959,740

G

C-X-C motif chemokine receptor 3

NCBI chr X:55,882,433...55,884,582
Ensembl chr X:55,882,433...55,884,582

G

cytochrome b-245 beta chain

NCBI chr X:32,533,365...32,568,149
Ensembl chr X:32,533,320...32,568,217

G

elastase, neutrophil expressed

NCBI chr20:57,789,044...57,790,932
Ensembl chr20:57,788,062...57,790,932

G

interleukin 17A

severity

NCBI chr12:19,854,129...19,862,521
Ensembl chr12:19,854,129...19,862,513

G

mannose binding lectin 1

DNA:SNP:exon:rs5030737(human)

NCBI chr 4:29,419,886...29,424,377

G

pentraxin 3

severity

protein:increased expression:bronchoalveolar lavage fluid (human)
DNA:SNPs, missense mutation:intron, cds:rs2305619, rs1840680, rs3816527

PMID:28487045 PMID:30275011

RGD:38501097 RGD:38508892

NCBI chr23:50,952,835...50,958,607
Ensembl chr23:50,952,885...50,958,167

G

S100 calcium binding protein B

NCBI chr31:39,783,990...39,788,289
Ensembl chr31:39,784,506...39,788,183

G

toll like receptor 2

NCBI chr15:51,454,557...51,465,429
Ensembl chr15:51,454,695...51,465,241

G

toll like receptor 4

susceptibility

DNA:polymorphism:exon:p.D299G(human)

NCBI chr11:71,356,390...71,367,166
Ensembl chr11:71,356,390...71,367,165

Invasive Pulmonary Aspergillosis

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

C-C motif chemokine ligand 2

treatment

NCBI chr 9:39,008,187...39,009,932

G

CD209 molecule

susceptibility

DNA:SNPs:3'utr,intron:multiple

NCBI chr20:52,517,759...52,542,085
Ensembl chr20:52,518,036...52,520,942

G

fibroblast growth factor 2

treatment

NCBI chr19:17,403,288...17,463,143
Ensembl chr19:16,994,661...17,463,151

G

interleukin 1 alpha

DNA:polymorphism, haplotype:promoter:-889C>T (human)

NCBI chr17:36,969,581...36,979,445
Ensembl chr17:36,970,573...36,979,435

G

interleukin 1 beta

DNA:polymorphism, haplotype: :-511C>T (human)

NCBI chr17:37,019,329...37,033,388
Ensembl chr17:37,019,329...37,024,458

G

inter-alpha-trypsin inhibitor heavy chain 4

protein:increased expression:respiratory system fluid/secretion, serum

G

mannose binding lectin 1

treatment

NCBI chr 4:29,419,886...29,424,377

G

pentraxin 3

susceptibility
no_association

DNA:SNP:intron:rs1840680 (human)
protein:increased expression:plasma
DNA:SNP, missense mutation:intron, cds:rs2305619, rs3816527
protein:increased expression:bronchoalveolar lavage fluid, plasma (human)

PMID:29020397 PMID:29964232

RGD:38501098 RGD:38508894

NCBI chr23:50,952,835...50,958,607
Ensembl chr23:50,952,885...50,958,167

G

vascular endothelial growth factor A

treatment

NCBI chr12:12,209,032...12,224,978
Ensembl chr12:12,208,231...12,224,965

Klebsiella pneumonia

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

C-X-C motif chemokine ligand 8

NCBI chr13:62,435,035...62,438,354
Ensembl chr13:62,434,422...62,438,354

G

interleukin 23 subunit alpha

severity

NCBI chr10:635,384...640,715
Ensembl chr10:638,719...640,359

G

interleukin 1 receptor associated kinase 3

severity

mRNA:increased expression:lung (mouse)

PMID:20864681 PMID:22729155

RGD:35316077 RGD:36049798

NCBI chr10:8,683,541...8,730,757
Ensembl chr10:8,684,242...8,729,268

G

lipocalin 2

ameliorates
exacerbates

protein:increased expression:lung
protein:increased expression:serum

PMID:19342674 PMID:25234944 PMID:29633303

RGD:126725082 RGD:126725084 RGD:126725085

NCBI chr 9:55,328,118...55,342,535
Ensembl chr 9:55,328,133...55,332,038

G

placenta associated 8 B

severity

NCBI chr32:7,004,147...7,049,877
Ensembl chr32:7,007,753...7,029,140

G

triggering receptor expressed on myeloid cells 1

disease_progression

NCBI chr12:9,990,678...10,000,195
Ensembl chr12:9,990,679...10,000,236

Legionnaires' disease

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

adenosine deaminase

protein:increased expression:serum

NCBI chr24:32,083,786...32,119,810
Ensembl chr24:32,083,931...32,111,160

G

C-X3-C motif chemokine ligand 1

NCBI chr 2:59,022,794...59,032,095
Ensembl chr 2:59,022,794...59,032,095

G

C-X-C motif chemokine receptor 2

NCBI chr37:24,831,351...24,846,387
Ensembl chr37:24,843,171...24,844,247

G

interferon gamma

CTD Direct Evidence: therapeutic

NCBI chr10:10,406,866...10,411,698
Ensembl chr10:10,406,867...10,411,698

G

interleukin 18

NCBI chr 5:20,972,742...20,995,327
Ensembl chr 5:20,972,871...20,995,348

G

mannose binding lectin 1

susceptibility

NCBI chr 4:29,419,886...29,424,377

G

nucleotide binding oligomerization domain containing 1

NCBI chr14:43,162,671...43,226,948
Ensembl chr14:43,163,571...43,227,103

G

nucleotide binding oligomerization domain containing 2

NCBI chr 2:64,636,850...64,667,232
Ensembl chr 2:64,635,519...64,667,232

G

toll like receptor 5

susceptibility

ClinVar Annotator: match by term: Legionnaire disease, susceptibility to

PMID:14623910 PMID:16027372 PMID:23447684

NCBI chr38:23,700,323...23,705,628
Ensembl chr38:23,702,033...23,705,314

G

toll like receptor 9

NCBI chr20:37,529,322...37,547,117
Ensembl chr20:37,542,340...37,547,114
Ensembl chr20:37,542,340...37,547,114

G

TNF receptor superfamily member 1A

NCBI chr27:38,641,837...38,654,693
Ensembl chr27:38,638,753...38,700,282

G

TNF receptor superfamily member 1B

NCBI chr 2:84,140,179...84,151,219
Ensembl chr 2:84,141,911...84,157,191

Mycoplasma pneumoniae pneumonia

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

adenosine deaminase

protein:increased expression:serum

NCBI chr24:32,083,786...32,119,810
Ensembl chr24:32,083,931...32,111,160

G

ATPase Na+/K+ transporting subunit beta 2

severity

NCBI chr 5:32,548,591...32,553,911
Ensembl chr 5:32,549,167...32,553,504

G

chemokine (C-C motif) ligand 4

NCBI chr 9:37,681,342...37,682,691
Ensembl chr 9:37,676,966...37,710,209

G

C-C motif chemokine ligand 5

protein:increased secretion:lung, secretion (mouse)

NCBI chr 9:37,817,409...37,823,852
Ensembl chr 9:37,817,305...37,823,852

G

C-C motif chemokine ligand 8

NCBI chr 9:38,949,184...38,950,702
Ensembl chr 9:38,948,184...38,950,803

G

C-C motif chemokine receptor 5

protein:increased expression:lung, T-helper cell (mouse)

NCBI chr20:42,293,288...42,297,952
Ensembl chr20:42,294,996...42,297,952

G

C-type lectin domain containing 5A

severity

NCBI chr16:7,242,424...7,269,986
Ensembl chr16:7,243,018...7,269,418

G

collagen type III alpha 1 chain

severity

NCBI chr36:30,488,250...30,526,367
Ensembl chr36:30,488,488...30,536,765

G

collagen type VI alpha 1 chain

severity

NCBI chr31:39,301,718...39,319,895
Ensembl chr31:39,301,748...39,448,062

G

collagen type VI alpha 2 chain

severity

NCBI chr31:39,433,174...39,448,051

G

C-reactive protein

NCBI chr38:22,396,787...22,398,180
Ensembl chr38:22,396,263...22,399,166

G

deoxyribonuclease 1L3

severity

NCBI chr20:32,350,138...32,379,240
Ensembl chr20:32,358,110...32,379,245

G

Fc epsilon receptor II

severity

NCBI chr20:52,451,637...52,460,045
Ensembl chr20:52,449,922...52,457,805

G

fms related receptor tyrosine kinase 1

severity

NCBI chr25:11,231,958...11,410,379
Ensembl chr25:11,231,737...11,407,621

G

galactosylceramidase

associated with Guillain-Barre syndrome; protein:increased expression:serum (human)
associated with Guillain-Barre syndrome; protein:increased expression:Cerebrospinal fluid, serum (human)
protein:increased expression:serum (mouse)

PMID:12225900 PMID:27490360 PMID:29301655 PMID:30396892

RGD:38599168 RGD:38599169 RGD:38599171 RGD:38599172

NCBI chr 8:59,266,693...59,324,825
Ensembl chr 8:59,267,818...59,324,967

G

histidine decarboxylase

NCBI chr30:16,201,222...16,223,452
Ensembl chr30:16,201,589...16,223,662

G

HtrA serine peptidase 3

severity

NCBI chr 3:60,081,087...60,111,847
Ensembl chr 3:60,081,087...60,111,170

G

interferon gamma

mRNA:increased expression:lung:

NCBI chr10:10,406,866...10,411,698
Ensembl chr10:10,406,867...10,411,698

G

interleukin 13

protein:increased expression:serum

NCBI chr11:20,957,870...20,961,391
Ensembl chr11:20,958,464...20,961,388

G

interleukin 22 receptor subunit alpha 2

severity

NCBI chr 1:29,611,096...29,631,811
Ensembl chr 1:29,611,722...29,631,473

G

inhibin subunit beta A

severity

NCBI chr18:8,272,978...8,288,432
Ensembl chr18:8,272,872...8,283,794

G

killer cell lectin like receptor F1

severity

NCBI chr27:36,149,971...36,157,803
Ensembl chr27:36,150,413...36,157,842

G

membrane spanning 4-domains A1

severity

NCBI chr21:50,722,142...50,734,934
Ensembl chr21:50,722,041...50,733,704

G

phospholipase D family member 4

severity

NCBI chr 8:72,410,076...72,417,681
Ensembl chr 8:72,416,637...72,417,384

G

Spi-B transcription factor

severity

NCBI chr 1:106,294,360...106,301,700
Ensembl chr 1:106,266,817...106,301,686

G

transcription factor 7

severity

NCBI chr11:22,313,113...22,346,221
Ensembl chr11:22,313,105...22,344,004

G

TCL1 family AKT coactivator A

severity

G

tumor necrosis factor

protein:increased expression:serum

NCBI chr12:1,074,561...1,076,425
Ensembl chr12:1,074,552...1,076,425

G

TNF receptor superfamily member 13C

severity

NCBI chr10:23,430,960...23,434,972
Ensembl chr10:23,433,052...23,438,946

nasopharyngitis

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

patched 1

mRNA:decreased expression:epithelium of nasopharynx

NCBI chr 1:71,246,750...71,309,036
Ensembl chr 1:71,238,195...71,305,662

Perennial Allergic Rhinitis

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

adiponectin, C1Q and collagen domain containing

protein:decreased expression:serum

NCBI chr34:19,398,310...19,410,519
Ensembl chr34:19,354,825...19,409,844

G

albumin

CTD Direct Evidence: marker/mechanism

NCBI chr13:62,133,747...62,169,349
Ensembl chr13:62,053,814...62,294,709

G

arachidonate 5-lipoxygenase activating protein

protein:increased expression:nasal turbinate

NCBI chr25:9,320,868...9,351,056
Ensembl chr25:9,320,864...9,351,836

G

catalase

protein:decreased expression:plasma

NCBI chr18:33,383,005...33,422,447
Ensembl chr18:33,383,005...33,422,447

G

C-C motif chemokine ligand 2

protein:increased expression:nasal turbinate, mucosa (human)

NCBI chr 9:39,008,187...39,009,932

G

C-C motif chemokine receptor 2

mRNA:increased expression:Nasal Mucosa

NCBI chr20:42,305,344...42,313,258
Ensembl chr20:42,307,580...42,308,698

G

C-C motif chemokine receptor 5

mRNA:increased expression:nasal mucosa (human)

NCBI chr20:42,293,288...42,297,952
Ensembl chr20:42,294,996...42,297,952

G

CD40 molecule

NCBI chr24:33,352,992...33,383,488
Ensembl chr24:33,372,930...33,383,301

G

CD86 molecule

protein:increased expression:nasal mucosa, dendritic cell (human)

NCBI chr33:25,256,267...25,318,855
Ensembl chr33:25,256,267...25,318,087

G

chitinase acidic

mRNA, protein:increased expression:turbinate, mucosa (human)

NCBI chr 6:40,754,906...40,766,779
Ensembl chr 6:40,754,993...40,766,891

G

early growth response 1

DNA:snp:5' utr:g.-4071A>G rs7729723 (human)

NCBI chr11:26,046,195...26,049,806
Ensembl chr11:26,046,228...26,048,575

G

F2R like trypsin receptor 1

NCBI chr 3:29,801,119...29,810,006
Ensembl chr 3:29,800,211...29,810,180

G

glutathione S-transferase pi 1

susceptibility

DNA:polymorphism:exon:p.I105V (rs1695) (human)

NCBI chr18:49,905,161...49,908,182
Ensembl chr18:49,905,161...49,908,182

G

heme oxygenase 1

mRNA, protein:increased expression: nasal mucosa

NCBI chr10:28,744,404...28,751,544
Ensembl chr10:28,743,795...28,751,773

G

intercellular adhesion molecule 1

protein:increased secretion:nasopharynx (human)
protein:increased expression:lung, endothelium (mouse)

PMID:19047814 PMID:19968652

RGD:4145464 RGD:4145520

NCBI chr20:50,818,715...50,827,914
Ensembl chr20:50,818,715...50,827,914

G

interferon gamma receptor 1

DNA: SNP: Leu467Pro

NCBI chr 1:29,646,776...29,669,669
Ensembl chr 1:29,647,552...29,669,578

G

interleukin 13

mRNA, protein:increased expression:nasal mucosa

NCBI chr11:20,957,870...20,961,391
Ensembl chr11:20,958,464...20,961,388

G

interleukin 17A

severity

protein:increased expression:serum

NCBI chr12:19,854,129...19,862,521
Ensembl chr12:19,854,129...19,862,513

G

interleukin 18

susceptibility

DNA:SNP:promoter:c. -607A>C (rs1946518) (human)

NCBI chr 5:20,972,742...20,995,327
Ensembl chr 5:20,972,871...20,995,348

G

interleukin 1 alpha

DNA:polymorphism:exon:c.4845G>T (human)

NCBI chr17:36,969,581...36,979,445
Ensembl chr17:36,970,573...36,979,435

G

interleukin 1 receptor type 1

NCBI chr10:40,825,986...40,897,898
Ensembl chr10:40,827,377...40,897,596

G

interleukin 2

protein:decreased expression:serum:

NCBI chr19:17,750,780...17,756,394
Ensembl chr19:17,750,780...17,756,394

G

interleukin 4

treatment

protein:increased expression:serum

PMID:9237816 PMID:15329007 PMID:21171297

RGD:5128559 RGD:7829804 RGD:7829817

NCBI chr11:20,972,693...20,981,539
Ensembl chr11:20,972,690...20,981,534

G

interleukin 5

protein: increased levels: sputum

NCBI chr11:20,825,469...20,827,269
Ensembl chr11:20,825,469...20,827,269

G

matrix metallopeptidase 2

protein:increased expression:nasal mucosa:

NCBI chr 2:60,471,092...60,492,991
Ensembl chr 2:60,471,257...60,494,113

G

matrix metallopeptidase 9

protein:increased expression:nasal mucosa:

NCBI chr24:33,274,260...33,281,116
Ensembl chr24:33,274,268...33,281,293

G

nitric oxide synthase 2

protein:increased expression:nasal mucosa

NCBI chr 9:42,171,821...42,210,217
Ensembl chr 9:42,171,821...42,208,588

G

nitric oxide synthase 3

DNA:snp:promoter:g.-786T>C (human)

NCBI chr16:15,054,196...15,072,454
Ensembl chr16:15,011,344...15,072,277

G

nuclear receptor subfamily 3 group C member 1

protein:altered expression:nasal mucosa

NCBI chr 2:38,124,568...38,242,510
Ensembl chr 2:38,123,190...38,240,755

G

peroxisome proliferator activated receptor gamma

mRNA, protein:increased expression:nasal mucosa (human)

NCBI chr20:6,134,618...6,265,481
Ensembl chr20:6,050,357...6,207,981

G

prostaglandin-endoperoxide synthase 1

protein:increased expression:respiratory system epithelium

NCBI chr 9:60,195,118...60,216,847
Ensembl chr 9:60,195,124...60,216,819

G

thromboxane A2 receptor

treatment

NCBI chr20:55,819,866...55,829,395
Ensembl chr20:55,824,410...55,828,980

pleural empyema

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

plasminogen activator, urokinase

Gene product used in treatment of disease

NCBI chr 4:24,329,139...24,333,893
Ensembl chr 4:24,328,925...24,334,851

G

tenascin C

protein:increased expression:pleura

NCBI chr11:69,077,532...69,169,673
Ensembl chr11:69,077,535...69,170,281

G

triggering receptor expressed on myeloid cells 1

treatment

NCBI chr12:9,990,678...10,000,195
Ensembl chr12:9,990,679...10,000,236

pleural tuberculosis

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

adenosine deaminase

protein:increased activity:pleural fluid:
protein:increased activity:serum:
protein:increased expression:serum:

PMID:1689629 PMID:1818842 PMID:18357489 PMID:21860532

RGD:152995280 RGD:152995288 RGD:152995292 RGD:152998934

NCBI chr24:32,083,786...32,119,810
Ensembl chr24:32,083,931...32,111,160

G

adenosine deaminase 2

treatment

NCBI chr27:44,883,573...44,912,930
Ensembl chr27:44,884,882...44,912,850

G

C-C motif chemokine ligand 22

NCBI chr 2:59,039,650...59,045,519
Ensembl chr 2:59,040,539...59,045,625

G

C-C motif chemokine receptor 2

NCBI chr20:42,305,344...42,313,258
Ensembl chr20:42,307,580...42,308,698

G

C-C motif chemokine receptor 5

protein:increased expression:pleural fluid, natural killer cell (human)

NCBI chr20:42,293,288...42,297,952
Ensembl chr20:42,294,996...42,297,952

G

forkhead box P3

disease_progression

associated with human immunodeficiency virus infectious disease;

NCBI chr X:42,331,229...42,362,841
Ensembl chr X:42,344,108...42,350,758

G

interleukin 1 beta

DNA:polymorphism: :3953T>C (human)

NCBI chr17:37,019,329...37,033,388
Ensembl chr17:37,019,329...37,024,458

G

interleukin 1 receptor antagonist

DNA:repeat (human)

NCBI chr17:37,236,690...37,250,424
Ensembl chr17:37,212,751...37,249,329

G

interleukin 27

exacerbates

protein:increased expression:alveolar system (human)
associated with Pleural Effusion;protein:increased expression:pleural fluid (human)

PMID:23962500 PMID:25753767 PMID:28844060 PMID:31819557

RGD:126790505 RGD:126790517 RGD:126790523 RGD:126790549

NCBI chr 6:18,243,988...18,248,369
Ensembl chr 6:18,244,040...18,247,635

G

interleukin 33

protein:increased expression:pleural fluid:

NCBI chr11:27,219,878...27,256,723
Ensembl chr11:27,219,878...27,256,721

G

matrix metallopeptidase 9

protein:increased expression:pleura:

NCBI chr24:33,274,260...33,281,116
Ensembl chr24:33,274,268...33,281,293

G

toll like receptor 4

NCBI chr11:71,356,390...71,367,166
Ensembl chr11:71,356,390...71,367,165

G

tenascin C

protein:increased expression:pleura

NCBI chr11:69,077,532...69,169,673
Ensembl chr11:69,077,535...69,170,281

pleurisy

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

adenosine deaminase

NCBI chr24:32,083,786...32,119,810
Ensembl chr24:32,083,931...32,111,160

G

arachidonate 5-lipoxygenase

NCBI chr28:2,170,920...2,218,765
Ensembl chr28:2,170,920...2,219,609

G

annexin A1

NCBI chr 1:84,744,159...84,763,011
Ensembl chr 1:84,744,163...84,763,011

G

bradykinin receptor B1

NCBI chr 8:65,017,655...65,028,899

G

bradykinin receptor B2

PMID:9208140 PMID:15316088

RGD:4891029 RGD:4891041

NCBI chr 8:64,974,588...65,005,682
Ensembl chr 8:64,974,997...65,003,407

G

complement C3

protein:increased activity:pleural cavity

NCBI chr20:53,566,226...53,598,365
Ensembl chr20:53,566,261...53,598,761

G

catalase

NCBI chr18:33,383,005...33,422,447
Ensembl chr18:33,383,005...33,422,447

G

C-C motif chemokine ligand 25

protein:increased expression:pleural fluid

NCBI chr20:52,689,674...52,722,291
Ensembl chr20:52,712,979...52,722,018

G

C-C motif chemokine ligand 5

protein:increased secretion:lung (mouse)

NCBI chr 9:37,817,409...37,823,852
Ensembl chr 9:37,817,305...37,823,852

G

C-C motif chemokine receptor 3

associated with Mycobacterium Infections

NCBI chr20:42,382,380...42,398,449
Ensembl chr20:42,383,135...42,384,217

G

colony stimulating factor 3

NCBI chr 9:22,529,643...22,532,326
Ensembl chr 9:22,530,698...22,533,108

G

C-X-C motif chemokine ligand 10

NCBI chr32:598,406...599,925
Ensembl chr32:597,987...599,979

G

endothelin receptor type A

NCBI chr15:45,823,472...45,878,527
Ensembl chr15:45,823,560...45,876,463

G

elastase, neutrophil expressed

NCBI chr20:57,789,044...57,790,932
Ensembl chr20:57,788,062...57,790,932

G

estrogen receptor 1

NCBI chr 1:42,081,952...42,368,544
Ensembl chr 1:42,081,969...42,368,544

G

intercellular adhesion molecule 1

CTD Direct Evidence: marker/mechanism
protein:increased expression:bronchial epithelium (mouse)
associated with Tuberculosis; protein:increased expression:pleural fluid, natural killer cell (human)

PMID:11181422 PMID:19056932 PMID:19714575

RGD:4145510 RGD:4145519

NCBI chr20:50,818,715...50,827,914
Ensembl chr20:50,818,715...50,827,914

G

interleukin 10

CTD Direct Evidence: marker/mechanism

NCBI chr 7:5,933,285...5,937,057
Ensembl chr 7:5,933,285...5,937,057

G

interleukin 15

NCBI chr19:1,339,607...1,364,762
Ensembl chr19:1,339,967...1,364,762

G

interleukin 17A

treatment

NCBI chr12:19,854,129...19,862,521
Ensembl chr12:19,854,129...19,862,513

G

interleukin 1 beta

protein:increased expression:lung
CTD Direct Evidence: marker/mechanism
protein:increased expression:pleural cavity, exudate (rat)

PMID:11181422 PMID:20141620 PMID:20175894 PMID:21898269

RGD:4142808 RGD:4142826 RGD:7175307

NCBI chr17:37,019,329...37,033,388
Ensembl chr17:37,019,329...37,024,458

G

interleukin 1 receptor antagonist

NCBI chr17:37,236,690...37,250,424
Ensembl chr17:37,212,751...37,249,329

G

interleukin 6

CTD Direct Evidence: marker/mechanism

NCBI chr14:36,474,268...36,478,519
Ensembl chr14:36,473,394...36,478,519

G

myeloperoxidase

protein:increased activity:lung

NCBI chr 9:32,927,483...32,938,007
Ensembl chr 9:32,927,483...32,937,820

G

NFE2 like bZIP transcription factor 2

NCBI chr36:20,989,205...21,087,044
Ensembl chr36:20,989,360...21,012,524

G

nitric oxide synthase 2

protein:increased expression:pleural cavity (rat)

PMID:20141620 PMID:21898269

RGD:4142808 RGD:7175307

NCBI chr 9:42,171,821...42,210,217
Ensembl chr 9:42,171,821...42,208,588

G

phospholipase A2 group VI

NCBI chr10:26,499,033...26,559,533
Ensembl chr10:26,509,695...26,634,087

G

platelet activating factor receptor

treatment

NCBI chr 2:72,225,386...72,256,353
Ensembl chr 2:72,225,386...72,256,352

G

prostaglandin-endoperoxide synthase 2

PMID:15740981 PMID:20141620

RGD:4142808 RGD:5143929

NCBI chr 7:19,668,079...19,674,903
Ensembl chr 7:19,668,082...19,674,903

G

selectin P

CTD Direct Evidence: marker/mechanism
protein:increased expression:lung

PMID:11181422 PMID:21147071

NCBI chr 7:28,956,428...28,997,266
Ensembl chr 7:28,958,486...28,996,313

G

serpin family E member 1

susceptibility

associated with Familial Mediterranean Fever;DNA: DNA:polymorphism:promoter:rs1799768 (human):

NCBI chr 6:8,719,547...8,727,160
Ensembl chr 6:8,720,825...8,726,301

G

tumor necrosis factor

CTD Direct Evidence: marker/mechanism

PMID:11161459 PMID:11181422 PMID:20141620

RGD:4142808 RGD:4143474

NCBI chr12:1,074,561...1,076,425
Ensembl chr12:1,074,552...1,076,425

pleuropneumonia

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

arachidonate 5-lipoxygenase

NCBI chr28:2,170,920...2,218,765
Ensembl chr28:2,170,920...2,219,609

Pneumococcal Pneumonia

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

activation induced cytidine deaminase

NCBI chr27:37,064,107...37,073,791
Ensembl chr27:37,064,080...37,073,789

G

arachidonate 5-lipoxygenase

NCBI chr28:2,170,920...2,218,765
Ensembl chr28:2,170,920...2,219,609

G

Bruton tyrosine kinase

ameliorates

NCBI chr X:75,270,952...75,302,663
Ensembl chr X:75,270,979...75,302,562

G

complement C3

disease_progression

protein:decreased expression:serum
associated with Liver Cirrhosis, Experimental;protein:decreased expression:respiratory system fluid/secretion

PMID:20405 PMID:15972516 PMID:17956621

RGD:5129509 RGD:5129523 RGD:5130163

NCBI chr20:53,566,226...53,598,365
Ensembl chr20:53,566,261...53,598,761

G

complement C5

severity

NCBI chr11:73,953,727...74,029,919
Ensembl chr11:73,953,727...74,029,851

G

C-C motif chemokine ligand 5

susceptibility

NCBI chr 9:37,817,409...37,823,852
Ensembl chr 9:37,817,305...37,823,852

G

CD14 molecule

NCBI chr 2:35,790,505...35,792,967

G

chitinase 3 like 1

protein:increased secretion:serum (human)

NCBI chr 7:25,620...32,954
Ensembl chr 7:26,316...33,427

G

corticotropin releasing hormone receptor 1

NCBI chr 9:9,708,696...9,763,281
Ensembl chr 9:9,714,204...9,763,402

G

corticotropin releasing hormone receptor 2

NCBI chr14:43,366,849...43,414,398
Ensembl chr14:43,368,340...43,415,142

G

C-reactive protein

disease_progression

NCBI chr38:22,396,787...22,398,180
Ensembl chr38:22,396,263...22,399,166

G

C-X-C motif chemokine ligand 8

CTD Direct Evidence: marker/mechanism

NCBI chr13:62,435,035...62,438,354
Ensembl chr13:62,434,422...62,438,354

G

defensin, beta 4A

CTD Direct Evidence: marker/mechanism

NCBI chr16:58,953,916...58,956,407
Ensembl chr16:58,953,916...58,956,407

G

heme oxygenase 1

associated with influenza;protein:increased expression:lung

NCBI chr10:28,744,404...28,751,544
Ensembl chr10:28,743,795...28,751,773

G

interleukin 15

protein:increased expression:alveolar macrophage, bronchial epithelial cell

NCBI chr19:1,339,607...1,364,762
Ensembl chr19:1,339,967...1,364,762

G

interleukin 15 receptor subunit alpha

NCBI chr 2:29,981,385...30,034,364
Ensembl chr 2:29,981,234...30,038,945

G

interleukin 17A

NCBI chr12:19,854,129...19,862,521
Ensembl chr12:19,854,129...19,862,513

G

interleukin 18

NCBI chr 5:20,972,742...20,995,327
Ensembl chr 5:20,972,871...20,995,348

G

interleukin 6

NCBI chr14:36,474,268...36,478,519
Ensembl chr14:36,473,394...36,478,519

G

leptin

NCBI chr14:8,115,396...8,130,946
Ensembl chr14:8,116,122...8,131,395

G

leptin receptor

NCBI chr 5:44,684,118...44,775,626
Ensembl chr 5:44,688,109...44,775,636

G

mitogen-activated protein kinase 1

CTD Direct Evidence: marker/mechanism

NCBI chr26:31,013,607...31,132,998
Ensembl chr26:31,013,607...31,132,998

G

mitogen-activated protein kinase 3

CTD Direct Evidence: marker/mechanism

NCBI chr 6:18,109,184...18,115,728
Ensembl chr 6:18,109,222...18,114,425

G

MBL associated serine protease 2

CTD Direct Evidence: marker/mechanism

NCBI chr 2:84,976,366...84,987,376
Ensembl chr 2:84,976,456...84,989,797

G

mannose binding lectin 1

no_association

DNA:mutations:5' utr, exon:multiple (human)
DNA:polymorphisms:5' utr, exon:multiple (human)

PMID:12047967 PMID:18641104

RGD:4889477 RGD:4889478

NCBI chr 4:29,419,886...29,424,377

G

nitric oxide synthase 2

NCBI chr 9:42,171,821...42,210,217
Ensembl chr 9:42,171,821...42,208,588

G

phosphatase and tensin homolog

ameliorates

myeloid knockout

NCBI chr26:37,853,148...37,913,176
Ensembl chr26:37,835,661...37,913,176

G

surfactant protein D

severity

NCBI chr 4:29,394,755...29,407,499
Ensembl chr 4:29,394,678...29,407,293

G

sirtuin 1

CTD Direct Evidence: marker/mechanism

NCBI chr 4:19,188,616...19,220,031
Ensembl chr 4:19,188,675...19,218,279

G

stimulator of interferon response cGAMP interactor 1

NCBI chr 2:34,783,947...34,792,204
Ensembl chr 2:34,784,232...34,789,072

G

toll like receptor 2

NCBI chr15:51,454,557...51,465,429
Ensembl chr15:51,454,695...51,465,241

G

tumor necrosis factor

associated with influenza;protein:increased expression:lung

PMID:9032201 PMID:17348295

RGD:4143479 RGD:4145366

NCBI chr12:1,074,561...1,076,425
Ensembl chr12:1,074,552...1,076,425

G

triggering receptor expressed on myeloid cells 1

ameliorates

PMID:19596984 PMID:24752755

RGD:126928121 RGD:127229903

NCBI chr12:9,990,678...10,000,195
Ensembl chr12:9,990,679...10,000,236

pneumocystosis

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

antizyme inhibitor 1

mRNA:increased expression:alveolar macrophage

NCBI chr13:4,363,996...4,396,069
Ensembl chr13:4,361,340...4,396,040

G

complement C3

NCBI chr20:53,566,226...53,598,365
Ensembl chr20:53,566,261...53,598,761

G

C-C motif chemokine ligand 2

protein:increased expression:respiratory system fluid/secretion

NCBI chr 9:39,008,187...39,009,932

G

CD40 molecule

treatment

NCBI chr24:33,352,992...33,383,488
Ensembl chr24:33,372,930...33,383,301

G

colony stimulating factor 2

protein:increased expression:respiratory system fluid/secretion

NCBI chr11:20,342,880...20,346,959
Ensembl chr11:20,344,648...20,346,959

G

major histocompatibility complex, class II, DQ beta 1

NCBI chr12:2,305,307...2,307,711

G

interleukin 23 subunit alpha

NCBI chr10:635,384...640,715
Ensembl chr10:638,719...640,359

G

interleukin 33

treatment

NCBI chr11:27,219,878...27,256,723
Ensembl chr11:27,219,878...27,256,721

G

pulmonary surfactant-associated protein A-like

protein:increased expression:lung

NCBI chr 4:29,430,139...29,434,640

G

mucin 1, cell surface associated

protein:increased expression:serum

NCBI chr 7:42,338,939...42,344,690
Ensembl chr 7:42,340,375...42,344,690

G

nitric oxide synthase 2

protein:decreased dimerization:alveolar macrophage
mRNA:increased expression:alveolar macrophage

PMID:20377877 PMID:20558778

RGD:4144112 RGD:4891486

NCBI chr 9:42,171,821...42,210,217
Ensembl chr 9:42,171,821...42,208,588

G

surfactant protein B

protein:decreased expression:lung

NCBI chr17:39,419,305...39,428,513
Ensembl chr17:39,386,584...39,426,229

G

surfactant protein C

protein:decreased expression:lung

NCBI chr25:35,088,295...35,090,995
Ensembl chr25:35,088,279...35,091,457

G

surfactant protein D

protein:increased expression:lung

NCBI chr 4:29,394,755...29,407,499
Ensembl chr 4:29,394,678...29,407,293

G

toll like receptor 2

NCBI chr15:51,454,557...51,465,429
Ensembl chr15:51,454,695...51,465,241

pneumonia

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

ATP binding cassette subfamily F member 1

CTD Direct Evidence: marker/mechanism

NCBI chr12:396,947...410,951
Ensembl chr12:401,118...411,179

G

ABO, alpha 1-3-N-acetylgalactosaminyltransferase and alpha 1-3-galactosyltransferase

severity

DNA:polymorphism:cds:allele A (human)

NCBI chr 9:49,746,749...49,758,317
Ensembl chr 9:49,748,693...49,758,479

G

angiotensin I converting enzyme

disease_progression

associated with Hypertension

PMID:17727310 PMID:19455553 PMID:20051911

RGD:4140916 RGD:4140918 RGD:4140922

NCBI chr 9:11,497,182...11,516,362
Ensembl chr 9:11,497,182...11,516,358

G

adenosine A1 receptor

NCBI chr 7:44,819...74,217
Ensembl chr 7:44,820...73,051

G

adenosine A2a receptor

associated with Lung Injury
associated with Anemia, Sickle Cell

PMID:17601796 PMID:18703794 PMID:20798237

RGD:4890358 RGD:4890364 RGD:4890376

NCBI chr26:28,141,076...28,150,600
Ensembl chr26:28,141,076...28,150,598

G

adrenoceptor beta 2

NCBI chr 4:60,048,502...60,050,447
Ensembl chr 4:59,941,517...60,050,298

G

angiotensinogen

CTD Direct Evidence: therapeutic

NCBI chr 4:8,681,192...8,694,059
Ensembl chr 4:8,683,798...8,693,880

G

aryl hydrocarbon receptor

CTD Direct Evidence: marker/mechanism

NCBI chr14:31,743,704...31,793,484
Ensembl chr14:31,686,170...31,791,444

G

albumin

disease_progression

NCBI chr13:62,133,747...62,169,349
Ensembl chr13:62,053,814...62,294,709

G

B9 domain containing 2

severity

CTD Direct Evidence: marker/mechanism
protein:increased expression:lung

PMID:19181604 PMID:19965809 PMID:21625544

RGD:4145120 RGD:4145141

NCBI chr 1:112,621,832...112,627,726
Ensembl chr 1:112,621,633...112,643,885

G

bradykinin receptor B2

NCBI chr 8:64,974,588...65,005,682
Ensembl chr 8:64,974,997...65,003,407

G

complement C3

NCBI chr20:53,566,226...53,598,365
Ensembl chr20:53,566,261...53,598,761

G

complement C3a receptor 1

associated with Respiratory Syncytial Virus Infections

NCBI chr27:37,431,745...37,439,858
Ensembl chr27:37,433,792...37,435,246

G

complement C5

associated with Respiratory Syncytial Virus Infections

PMID:3631740 PMID:17079327

RGD:5129688 RGD:5130161

NCBI chr11:73,953,727...74,029,919
Ensembl chr11:73,953,727...74,029,851

G

chemokine (C-C motif) ligand 13

CTD Direct Evidence: marker/mechanism

NCBI chr 9:38,938,944...38,940,231
Ensembl chr 9:38,938,135...38,940,231

G

C-C motif chemokine ligand 17

CTD Direct Evidence: marker/mechanism
mRNA:increased expression:lung

PMID:15993846 PMID:21625544

NCBI chr 2:59,001,463...59,014,347
Ensembl chr 2:59,001,464...59,005,230

G

C-C motif chemokine ligand 19

CTD Direct Evidence: marker/mechanism

NCBI chr11:51,357,706...51,359,207
Ensembl chr11:51,340,530...51,359,365

G

C-C motif chemokine ligand 2

CTD Direct Evidence: marker/mechanism
protein:increased expression:respiratory system fluid/secretion

PMID:19648283 PMID:21625544

NCBI chr 9:39,008,187...39,009,932

G

C-C motif chemokine ligand 20

CTD Direct Evidence: marker/mechanism

NCBI chr25:40,506,385...40,509,903
Ensembl chr25:40,506,753...40,509,709

G

C-C motif chemokine ligand 22

mRNA:increased expression:lung

NCBI chr 2:59,039,650...59,045,519
Ensembl chr 2:59,040,539...59,045,625

G

C-C motif chemokine ligand 24

CTD Direct Evidence: marker/mechanism

NCBI chr 6:7,166,165...7,179,606
Ensembl chr 6:7,166,479...7,180,051

G

chemokine (C-C motif) ligand 4

CTD Direct Evidence: marker/mechanism
mRNA:increased expression:bronchoalveolar lavage (human)

PMID:21625544 PMID:32407669

NCBI chr 9:37,681,342...37,682,691
Ensembl chr 9:37,676,966...37,710,209

G

C-C motif chemokine ligand 7

CTD Direct Evidence: marker/mechanism

PMID:15191918 PMID:21625544

NCBI chr 9:38,994,638...38,996,103
Ensembl chr 9:38,993,911...39,010,483

G

C-C motif chemokine ligand 8

CTD Direct Evidence: marker/mechanism

NCBI chr 9:38,949,184...38,950,702
Ensembl chr 9:38,948,184...38,950,803

G

chemokine (C-C motif) receptor 1

CTD Direct Evidence: marker/mechanism

PMID:20870892 PMID:21625544

NCBI chr20:42,421,356...42,427,177
Ensembl chr20:42,421,356...42,426,958

G

C-C motif chemokine receptor 2

CTD Direct Evidence: marker/mechanism

PMID:14615370 PMID:17284325 PMID:21625544

RGD:4145068 RGD:8661704

NCBI chr20:42,305,344...42,313,258
Ensembl chr20:42,307,580...42,308,698

G

C-C motif chemokine receptor 3

mRNA:increased expression:lung

NCBI chr20:42,382,380...42,398,449
Ensembl chr20:42,383,135...42,384,217

G

C-C motif chemokine receptor 5

Idiopathic Pneumonia Syndrome; mRNA:increased expression:lung (mouse)

NCBI chr20:42,293,288...42,297,952
Ensembl chr20:42,294,996...42,297,952

G

C-C motif chemokine receptor 6

CTD Direct Evidence: marker/mechanism

NCBI chr 1:54,932,798...54,960,646
Ensembl chr 1:54,932,690...54,959,740

G

C-C motif chemokine receptor 7

mRNA, protein:increased expression:lung

NCBI chr 9:22,077,976...22,092,818
Ensembl chr 9:22,068,775...22,090,656

G

C-C motif chemokine receptor 9

CTD Direct Evidence: marker/mechanism

NCBI chr20:42,607,024...42,616,823
Ensembl chr20:42,607,024...42,616,823

G

CD14 molecule

protein:increased expression:multiple

NCBI chr 2:35,790,505...35,792,967

G

CD163 molecule

associated with liver disease;protein:increased expression:blood serum (human)

NCBI chr27:37,669,757...37,700,746
Ensembl chr27:37,669,827...37,753,106

G

CD40 ligand

CTD Direct Evidence: marker/mechanism

NCBI chr X:107,001,421...107,023,007
Ensembl chr X:107,010,890...107,023,006

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coenzyme Q6, monooxygenase

ClinVar Annotator: match by term: increased susceptibility to pneumonia

NCBI chr 8:47,177,376...47,190,143
Ensembl chr 8:47,177,358...47,190,141

G

corticotropin releasing hormone receptor 2

NCBI chr14:43,366,849...43,414,398
Ensembl chr14:43,368,340...43,415,142

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C-reactive protein

disease_progression
severity

PMID:21258955 PMID:21439658

RGD:5131283 RGD:5131291

NCBI chr38:22,396,787...22,398,180
Ensembl chr38:22,396,263...22,399,166

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colony stimulating factor 2

CTD Direct Evidence: marker/mechanism

PMID:11732872 PMID:19633061

NCBI chr11:20,342,880...20,346,959
Ensembl chr11:20,344,648...20,346,959

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colony stimulating factor 3 receptor

mRNA:increased expression:bronchoalveolar lavage (human)

NCBI chr15:5,818,985...5,832,455
Ensembl chr15:5,822,025...5,831,882

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C-terminal Src kinase

NCBI chr30:37,851,269...37,870,382
Ensembl chr30:37,852,046...37,870,378

G

C-X3-C motif chemokine ligand 1

CTD Direct Evidence: marker/mechanism

NCBI chr 2:59,022,794...59,032,095
Ensembl chr 2:59,022,794...59,032,095

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C-X-C motif chemokine ligand 10

associated with Lupus Erythematosus, Systemic;mRNA:increased expression:lung

PMID:14979941 PMID:15265940

RGD:5135445 RGD:5135491

NCBI chr32:598,406...599,925
Ensembl chr32:597,987...599,979

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C-X-C motif chemokine ligand 8

CTD Direct Evidence: marker/mechanism
mRNA:increased expression:bronchoalveolar lavage (human)

PMID:21625544 PMID:32407669

NCBI chr13:62,435,035...62,438,354
Ensembl chr13:62,434,422...62,438,354

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C-X-C motif chemokine receptor 2

CTD Direct Evidence: marker/mechanism

NCBI chr37:24,831,351...24,846,387
Ensembl chr37:24,843,171...24,844,247

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C-X-C motif chemokine receptor 3

associated with Lupus Erythematosus, Systemic;mRNA:increased expression:lung
CTD Direct Evidence: marker/mechanism

PMID:14979941 PMID:15265940 PMID:21625544

RGD:5135445 RGD:5135491

NCBI chr X:55,882,433...55,884,582
Ensembl chr X:55,882,433...55,884,582

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cytochrome P450 family 1 subfamily A member 1

susceptibility

DNA:polymorphism (human)

NCBI chr30:37,793,277...37,799,535
Ensembl chr30:37,793,508...37,796,866

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cytochrome P450 family 2 subfamily E member 1

protein:increased expression:alveolus, epithelial cell
DNA:polymorphism (human)

PMID:14698565 PMID:15928955

RGD:4142512 RGD:4892223

NCBI chr28:41,079,164...41,089,188
Ensembl chr28:41,035,025...41,122,754

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defensin beta 1

protein:increased expression:serum

NCBI chr16:58,871,018...58,881,592
Ensembl chr16:58,871,018...58,881,592

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endothelin 1

severity

protein:increased secretion:plasma (human)

NCBI chr35:11,808,892...11,815,383
Ensembl chr35:11,808,892...11,815,383

G

epidermal growth factor

resistance

NCBI chr32:30,073,541...30,166,904
Ensembl chr32:30,073,950...30,166,295

G

early growth response 1

CTD Direct Evidence: therapeutic

NCBI chr11:26,046,195...26,049,806
Ensembl chr11:26,046,228...26,048,575

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ectonucleoside triphosphate diphosphohydrolase 5 (inactive)

ClinVar Annotator: match by term: increased susceptibility to pneumonia

NCBI chr 8:47,193,463...47,245,865
Ensembl chr 8:47,196,439...47,229,964

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gastrin releasing peptide

protein:increased expression:serum (human)

NCBI chr 1:16,974,818...16,987,578
Ensembl chr 1:16,975,113...16,987,531

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histidine decarboxylase

NCBI chr30:16,201,222...16,223,452
Ensembl chr30:16,201,589...16,223,662

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heme oxygenase 1

susceptibility

DNA:allele:promoter:L allele of the (GT)n repeat (>30 repeats)
CTD Direct Evidence: marker/mechanism

NCBI chr10:28,744,404...28,751,544
Ensembl chr10:28,743,795...28,751,773

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intercellular adhesion molecule 1

treatment

associated with Reperfusion Injury

NCBI chr20:50,818,715...50,827,914
Ensembl chr20:50,818,715...50,827,914

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interferon alpha and beta receptor subunit 1

resistance

Cryptococcus (yeast) pneumonia

NCBI chr31:28,854,765...28,876,399

G

interferon gamma

CTD Direct Evidence: marker/mechanism

NCBI chr10:10,406,866...10,411,698
Ensembl chr10:10,406,867...10,411,698

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inhibitor of nuclear factor kappa B kinase subunit beta

treatment

CTD Direct Evidence: marker/mechanism

PMID:20080200 PMID:31095431

NCBI chr16:23,359,551...23,419,114
Ensembl chr16:23,359,813...23,419,075

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interleukin 10

disease_progression

protein:increased expression:blood

NCBI chr 7:5,933,285...5,937,057
Ensembl chr 7:5,933,285...5,937,057

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interleukin 13

associated with Respiratory Distress Syndrome, Newborn; protein:increased expression:bronchoalveolar lavage fluid
CTD Direct Evidence: marker/mechanism

PMID:19695190 PMID:21625544

NCBI chr11:20,957,870...20,961,391
Ensembl chr11:20,958,464...20,961,388

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interleukin 13 receptor subunit alpha 2

mRNA:increased expression:lung, fibroblast

NCBI chr X:87,747,373...87,776,797
Ensembl chr X:87,747,373...87,776,798

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interleukin 17A

CTD Direct Evidence: marker/mechanism

PMID:20498020 PMID:21625544 PMID:22848348

RGD:4888524 RGD:9068417

NCBI chr12:19,854,129...19,862,521
Ensembl chr12:19,854,129...19,862,513

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interleukin 18

associated with reperfusion injury
CTD Direct Evidence: marker/mechanism
protein:increased expression:serum
mRNA, protein:increased expression:lung,bronchoalveolar fluid

PMID:11739527 PMID:15955140 PMID:16052682 PMID:17400729 PMID:21625544

RGD:4889590 RGD:4889825 RGD:4889836 RGD:729357

NCBI chr 5:20,972,742...20,995,327
Ensembl chr 5:20,972,871...20,995,348

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interleukin 1 alpha

mRNA:increased expression:lung

NCBI chr17:36,969,581...36,979,445
Ensembl chr17:36,970,573...36,979,435

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interleukin 1 beta

mRNA:increased expression:bronchoalveolar lavage (human)
CTD Direct Evidence: marker/mechanism
mRNA, protein:increased expression:lung
mRNA:increased expression:lung

PMID:19825784 PMID:19901996 PMID:20007584 PMID:20155581 PMID:20476872 More...

RGD:30296672 RGD:4142536 RGD:4142812 RGD:4142827 RGD:4142831 RGD:4143211

NCBI chr17:37,019,329...37,033,388
Ensembl chr17:37,019,329...37,024,458

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interleukin 1 receptor type 1

CTD Direct Evidence: marker/mechanism

NCBI chr10:40,825,986...40,897,898
Ensembl chr10:40,827,377...40,897,596

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interleukin 1 receptor type 2

CTD Direct Evidence: marker/mechanism
mRNA:increased expression:bronchoalveolar lavage (human)

PMID:21625544 PMID:32407669

NCBI chr10:40,967,532...41,003,659
Ensembl chr10:40,896,669...41,034,113

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interleukin 1 receptor antagonist

disease_progression
no_association

mRNA:increased expression:bronchoalveolar lavage (human)
mRNA:increased expression:bronchioalveolar lavage fluid, neutrophil (rat)
DNA:polymorphism:intron (human)
DNA:polymorphism (human)
mRNA:increased expression:lung

PMID:1385928 PMID:16369129 PMID:17569781 PMID:18838927 PMID:19900796 More...

RGD:30296672 RGD:4142865 RGD:4142871 RGD:4143204 RGD:4143213 RGD:8551846

NCBI chr17:37,236,690...37,250,424
Ensembl chr17:37,212,751...37,249,329

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interleukin 27

NCBI chr 6:18,243,988...18,248,369
Ensembl chr 6:18,244,040...18,247,635

G

interleukin 2 receptor subunit beta

CTD Direct Evidence: marker/mechanism

NCBI chr10:27,370,797...27,388,775
Ensembl chr10:27,370,797...27,388,775

G

interleukin 32

mRNA:increased expression:peripheral blood mononuclear cell, blood plasma (human)

NCBI chr 6:38,119,287...38,122,979

G

interleukin 33

CTD Direct Evidence: marker/mechanism

NCBI chr11:27,219,878...27,256,723
Ensembl chr11:27,219,878...27,256,721

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interleukin 4

CTD Direct Evidence: marker/mechanism
mRNA:increased expression:bronchoalveolar lavage (human)

PMID:21625544 PMID:32407669

NCBI chr11:20,972,693...20,981,539
Ensembl chr11:20,972,690...20,981,534

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interleukin 4 receptor

mRNA:decreased expression:bronchoalveolar lavage (human)

NCBI chr 6:19,254,183...19,280,973
Ensembl chr 6:19,254,487...19,389,291

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interleukin 5 receptor subunit alpha

CTD Direct Evidence: marker/mechanism

NCBI chr20:14,309,805...14,349,433
Ensembl chr20:14,314,227...14,343,793

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interleukin 6

disease_progression

protein:increased expression:blood
CTD Direct Evidence: marker/mechanism

PMID:20595152 PMID:21625544

NCBI chr14:36,474,268...36,478,519
Ensembl chr14:36,473,394...36,478,519