RGD DISEASE ONTOLOGY - ANNOTATIONS |
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RGD uses the Human Disease Ontology (DO, https://disease-ontology.org/) for disease curation across species. RGD automatically downloads each new release of the ontology on a monthly basis. Some additional terms which are required for RGD's curation purposes but are not currently covered in the official version of DO have been added. As corresponding terms are added to DO, these custom terms are retired and the DO terms substituted in existing annotations and subsequently used for curation.
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Term: | Respiratory Tract Infections |
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Accession: | DOID:9008680
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browse the term
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Definition: | Invasion of the host RESPIRATORY SYSTEM by microorganisms, usually leading to pathological processes or diseases. |
Synonyms: | exact_synonym: | Respiratory Infection, Upper; Respiratory Infections; Respiratory Tract Infection; Upper Respiratory Infections; Upper Respiratory Tract Infections |
| primary_id: | MESH:D012141; RDO:0000329 |
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Bdnf |
brain-derived neurotrophic factor |
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ISO |
protein:decreased expression:platelet, serum |
RGD |
PMID:17317133 |
RGD:4891069 |
NCBI chr 3:96,165,042...96,215,621
Ensembl chr 3:96,165,042...96,215,615
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Cxcr3 |
C-X-C motif chemokine receptor 3 |
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ISO |
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RGD |
PMID:19039768 |
RGD:4892119 |
NCBI chr X:66,844,318...66,846,969
Ensembl chr X:66,844,318...66,846,969
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Fbln5 |
fibulin 5 |
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ISO |
CTD Direct Evidence: marker/mechanism |
CTD |
PMID:12189163 |
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NCBI chr 6:120,899,219...120,977,829
Ensembl chr 6:120,899,224...120,977,755
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Il13 |
interleukin 13 |
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ISO |
Severe Acute Respiratory Syndrome |
RGD |
PMID:14633438 |
RGD:4145665 |
NCBI chr10:37,790,130...37,792,687
Ensembl chr10:37,790,130...37,792,737
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Il16 |
interleukin 16 |
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ISO |
protein:increased expression:serum |
RGD |
PMID:14633438 |
RGD:4145665 |
NCBI chr 1:137,617,702...137,718,022
Ensembl chr 1:137,617,944...137,718,130
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Il4 |
interleukin 4 |
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ISO |
associated with Asthma |
RGD |
PMID:20573437 |
RGD:5128554 |
NCBI chr10:37,771,203...37,776,750
Ensembl chr10:37,771,203...37,776,750
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Il6r |
interleukin 6 receptor |
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ISO |
DNA:polymorphisms:promoter, exon:-183G>A (human) |
RGD |
PMID:20951753 |
RGD:5128631 |
NCBI chr 2:175,289,157...175,347,719
Ensembl chr 2:175,298,686...175,347,536
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Irf1 |
interferon regulatory factor 1 |
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ISO |
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RGD |
PMID:10497103 |
RGD:5128721 |
NCBI chr10:37,917,155...37,924,166
Ensembl chr10:37,916,670...37,924,166
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Irf3 |
interferon regulatory factor 3 |
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ISO |
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RGD |
PMID:17027894 |
RGD:5128795 |
NCBI chr 1:95,479,966...95,484,926
Ensembl chr 1:95,479,821...95,484,935
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Lepr |
leptin receptor |
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ISO |
CTD Direct Evidence: marker/mechanism |
CTD |
PMID:17229951 |
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NCBI chr 5:116,294,409...116,477,904
Ensembl chr 5:116,289,823...116,475,908
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Mbl2 |
mannose binding lectin 2 |
susceptibility |
ISO |
protein:decreased secretion:serum (human) DNA:polymorphisms:5' utr, exon:multiple (human) DNA:SNP:exon:p.G54D(rs1800450)(human) |
RGD |
PMID:19169708 PMID:19767106 PMID:15249448 |
RGD:4889453, RGD:4889439, RGD:8693755 |
NCBI chr 1:228,016,439...228,024,736
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Mx1 |
MX dynamin like GTPase 1 |
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ISO |
protein:increased expression:blood (human) |
RGD |
PMID:25542463 |
RGD:126777677 |
NCBI chr11:36,799,659...36,825,209
Ensembl chr11:36,799,660...36,823,507
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Rpgr |
retinitis pigmentosa GTPase regulator |
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ISO |
CTD Direct Evidence: marker/mechanism |
CTD |
PMID:12920075 |
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NCBI chr X:12,566,447...12,628,171
Ensembl chr X:12,566,645...12,747,882
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RT1-M3-1 |
RT1 class Ib, locus M3, gene 1 |
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ISO |
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RGD |
PMID:19775370 |
RGD:5144114 |
NCBI chr20:1,323,976...1,328,126
Ensembl chr20:1,287,521...1,328,117
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Tnf |
tumor necrosis factor |
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ISO |
Severe Acute Respiratory Syndrome; protein:increased expression:serum |
RGD |
PMID:14633438 |
RGD:4145665 |
NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629
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Ccl17 |
C-C motif chemokine ligand 17 |
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ISO |
associated with Cystic Fibrosis |
RGD |
PMID:17898016 |
RGD:4145612 |
NCBI chr19:10,202,128...10,203,903
Ensembl chr19:10,202,128...10,203,819
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Ccr1 |
C-C motif chemokine receptor 1 |
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ISO |
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RGD |
PMID:15951834 |
RGD:5688155 |
NCBI chr 8:123,556,286...123,561,841
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Ccr2 |
C-C motif chemokine receptor 2 |
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ISO |
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RGD |
PMID:10946288 |
RGD:8661731 |
NCBI chr 8:123,734,465...123,742,483
Ensembl chr 8:123,734,430...123,742,100
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Cftr |
CF transmembrane conductance regulator |
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ISO |
DNA:mutations: : |
RGD |
PMID:11243954 |
RGD:4140482 |
NCBI chr 4:46,561,269...46,728,759
Ensembl chr 4:46,560,885...46,728,756
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Icam1 |
intercellular adhesion molecule 1 |
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ISO |
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RGD |
PMID:7743671 |
RGD:8547590 |
NCBI chr 8:19,553,063...19,565,438
Ensembl chr 8:19,553,645...19,565,438
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Il1a |
interleukin 1 alpha |
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ISO |
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RGD |
PMID:8699818 |
RGD:7794730 |
NCBI chr 3:116,526,601...116,537,055
Ensembl chr 3:116,526,604...116,536,822
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Mbl2 |
mannose binding lectin 2 |
susceptibility |
ISO |
Chronic Necrotizing Pulmonary Aspergillosis; DNA:missense mutation:exon:p.R52C (human) DNA:SNP:intron:1011G>A(human) |
RGD |
PMID:11474427 PMID:16487239 |
RGD:4889577, RGD:8693711 |
NCBI chr 1:228,016,439...228,024,736
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RT1-Bb |
RT1 class II, locus Bb |
susceptibility |
ISO |
associated with cystic fibrosis; DNA:polymorphisms: :DQB1*06:02, DQB1*02:01(human) |
RGD |
PMID:23278646 |
RGD:36049760 |
NCBI chr20:4,596,558...4,602,201
Ensembl chr20:4,596,559...4,607,597
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RT1-Db1 |
RT1 class II, locus Db1 |
susceptibility |
ISO |
associated with cystic fibrosis; DNA:polymorphisms: : |
RGD |
PMID:23278646 |
RGD:36049760 |
NCBI chr20:4,548,664...4,558,237
Ensembl chr20:4,548,666...4,558,258
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Tlr9 |
toll-like receptor 9 |
susceptibility |
ISO |
DNA:SNP:promoter:g.-1237T>C rs5743836 (human) |
RGD |
PMID:18275280 PMID:18936185 |
RGD:5130863, RGD:5130858 |
NCBI chr 8:106,864,680...106,868,796
Ensembl chr 8:106,864,680...106,868,796
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Tnf |
tumor necrosis factor |
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ISO |
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RGD |
PMID:8699818 |
RGD:7794730 |
NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629
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Tnfrsf1a |
TNF receptor superfamily member 1A |
susceptibility |
ISO |
DNA:snps:5' utr, exon:g.-609G>T rs4149570, g.36A>G rs767455 (human) |
RGD |
PMID:20646338 |
RGD:5131174 |
NCBI chr 4:158,150,815...158,163,592
Ensembl chr 4:158,150,820...158,163,591
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Abcb1a |
ATP binding cassette subfamily B member 1A |
severity |
ISO |
DNA:snp:exon:c.1236C>T (human) |
RGD |
PMID:24040855 |
RGD:8657076 |
NCBI chr 4:25,357,467...25,529,941
Ensembl chr 4:25,158,362...25,442,709
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Ace |
angiotensin I converting enzyme |
no_association |
ISO |
DNA:deletion:intron:IVS16+1464-1751del (human) |
RGD |
PMID:15112973 |
RGD:8142345 |
NCBI chr10:90,910,316...90,930,437
Ensembl chr10:90,910,316...90,931,131
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Bcl2 |
BCL2, apoptosis regulator |
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IEP |
mRNA, protein:increased expression:nasal mucosa (rat) |
RGD |
PMID:15362690 |
RGD:11522724 |
NCBI chr13:22,689,783...22,853,920
Ensembl chr13:22,684,989...22,853,743 Ensembl chr13:22,684,989...22,853,743
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Cat |
catalase |
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ISO |
CTD Direct Evidence: marker/mechanism |
CTD |
PMID:29028686 |
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NCBI chr 3:89,842,393...89,874,577
Ensembl chr 3:89,842,399...89,874,478
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Ccl11 |
C-C motif chemokine ligand 11 |
treatment |
IDA |
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RGD |
PMID:23089405 |
RGD:7248414 |
NCBI chr10:67,028,328...67,032,929
Ensembl chr10:67,028,328...67,032,926
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Ccl26 |
C-C motif chemokine ligand 26 |
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ISO |
protein:increased expression:oronasal secretion (human) |
RGD |
PMID:23883806 |
RGD:7364793 |
NCBI chr12:21,109,384...21,114,336
Ensembl chr12:21,109,421...21,114,335
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Cd40 |
CD40 molecule |
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ISO |
protein:increased expression:lymphocyte |
RGD |
PMID:19086656 |
RGD:8547782 |
NCBI chr 3:153,790,372...153,805,279
Ensembl chr 3:153,790,449...153,805,534
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Cd40lg |
CD40 ligand |
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ISO |
protein:increased expression:lymphocyte |
RGD |
PMID:19086656 |
RGD:8547782 |
NCBI chr X:135,127,052...135,138,768
Ensembl chr X:135,126,969...135,138,306
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Cldn3 |
claudin 3 |
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ISO |
CTD Direct Evidence: marker/mechanism |
CTD |
PMID:33441633 |
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NCBI chr12:21,708,538...21,710,010
Ensembl chr12:21,708,398...21,711,001
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Cldn7 |
claudin 7 |
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ISO |
CTD Direct Evidence: marker/mechanism |
CTD |
PMID:33441633 |
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NCBI chr10:54,689,684...54,692,177
Ensembl chr10:54,689,987...54,692,171
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Ctla4 |
cytotoxic T-lymphocyte-associated protein 4 |
treatment |
ISO |
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RGD |
PMID:10436391 |
RGD:11344920 |
NCBI chr 9:62,318,874...62,325,978
Ensembl chr 9:62,319,312...62,324,963
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F2 |
coagulation factor II, thrombin |
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ISO |
protein:increased expression:nasal mucus |
RGD |
PMID:21711961 |
RGD:5147783 |
NCBI chr 3:77,596,196...77,609,486
Ensembl chr 3:77,596,198...77,609,486
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Fcgr3a |
Fc gamma receptor 3A |
susceptibility |
ISO |
DNA:polymorphism:exon:p.F158V(rs396991)(human) |
RGD |
PMID:18199088 |
RGD:5508449 |
NCBI chr13:83,249,905...83,259,921
Ensembl chr13:83,249,872...83,259,921
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Gria1 |
glutamate ionotropic receptor AMPA type subunit 1 |
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ISO |
CTD Direct Evidence: marker/mechanism |
CTD |
PMID:34624383 |
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NCBI chr10:41,210,713...41,527,283
Ensembl chr10:41,210,713...41,527,283
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Gria2 |
glutamate ionotropic receptor AMPA type subunit 2 |
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ISO |
CTD Direct Evidence: marker/mechanism |
CTD |
PMID:34624383 |
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NCBI chr 2:165,949,379...166,069,510
Ensembl chr 2:165,947,521...166,069,510
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Hmox1 |
heme oxygenase 1 |
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ISO |
CTD Direct Evidence: marker/mechanism |
CTD |
PMID:36127783 |
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NCBI chr19:13,466,287...13,474,082
Ensembl chr19:13,467,244...13,474,079
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Hrh1 |
histamine receptor H 1 |
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ISO |
CTD Direct Evidence: marker/mechanism |
CTD |
PMID:23333628 |
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NCBI chr 4:147,564,963...147,649,353
Ensembl chr 4:147,645,995...147,647,455
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Ifng |
interferon gamma |
treatment |
ISO IDA |
associated with Asthma CTD Direct Evidence: marker/mechanism |
CTD RGD |
PMID:29871060 PMID:12787306 PMID:18510219 |
RGD:7829803, RGD:10755770 |
NCBI chr 7:53,903,339...53,907,375
Ensembl chr 7:53,903,337...53,907,375
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Il10 |
interleukin 10 |
treatment |
ISO |
CTD Direct Evidence: marker/mechanism |
CTD RGD |
PMID:36127783 PMID:23883806 PMID:23253209 |
RGD:7364793, RGD:7364818 |
NCBI chr13:42,472,625...42,477,308
Ensembl chr13:42,472,839...42,477,313
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Il13 |
interleukin 13 |
susceptibility no_association |
ISO |
DNA:polymorphism:exon:c. 2044G>A (human) CTD Direct Evidence: marker/mechanism DNA:missense mutation:cds:p.R130Q (rs20541) (human) DNA:SNPs:promoter, cds:-1112C>T, p.R130Q (rs1800925, rs20541) (human) DNA:SNP:promoter:-1512A>C (rs1881457) (human) |
CTD OMIM RGD |
PMID:17091279 PMID:22852128 PMID:12928861 PMID:23996716 |
RGD:4152796, RGD:8549518, RGD:8549516, RGD:8549501 |
NCBI chr10:37,790,130...37,792,687
Ensembl chr10:37,790,130...37,792,737
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Il13ra2 |
interleukin 13 receptor subunit alpha 2 |
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ISO |
protein:increased expression:serum |
RGD |
PMID:21462799 |
RGD:8549521 |
NCBI chr X:111,002,590...111,074,053
Ensembl chr X:111,002,592...111,072,381
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Il17a |
interleukin 17A |
susceptibility |
ISO |
DNA:snp:promoter:c.-444A>G (human) mRNA:increased expression:peripheral blood mononuclear cell (human) |
RGD |
PMID:22507625 PMID:21535180 |
RGD:9068429, RGD:5147409 |
NCBI chr 9:23,144,402...23,147,889
Ensembl chr 9:23,144,402...23,147,889
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Il18 |
interleukin 18 |
severity no_association |
ISO |
DNA:SNP:promoter:-137G>C (rs187238) (human) DNA:SNP:promoter:-140C>G (rs360721) (human) |
RGD |
PMID:22840759 PMID:22840759 |
RGD:8655914, RGD:8655914 |
NCBI chr 8:50,904,630...50,932,887
Ensembl chr 8:50,906,960...50,932,887
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Il1b |
interleukin 1 beta |
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ISO |
protein:increased expression:nasal mucus |
RGD |
PMID:7750009 |
RGD:7401199 |
NCBI chr 3:116,577,005...116,583,386
Ensembl chr 3:116,577,010...116,583,415
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Il2 |
interleukin 2 |
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IEP |
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RGD |
PMID:12592663 |
RGD:8662963 |
NCBI chr 2:120,004,862...120,009,566
Ensembl chr 2:120,004,862...120,009,566
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Il4 |
interleukin 4 |
treatment |
ISO IEP |
CTD Direct Evidence: marker/mechanism |
CTD RGD |
PMID:36127783 PMID:9893928 PMID:24620662 PMID:8908280 PMID:14653048 |
RGD:7829796, RGD:11522769, RGD:7829827, RGD:7829802 |
NCBI chr10:37,771,203...37,776,750
Ensembl chr10:37,771,203...37,776,750
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Il5 |
interleukin 5 |
treatment |
IEP |
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RGD |
PMID:23934070 PMID:24620662 |
RGD:11354976, RGD:11522769 |
NCBI chr10:37,874,342...37,877,213
Ensembl chr10:37,874,342...37,877,213
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Itgb2 |
integrin subunit beta 2 |
treatment |
IEP |
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RGD |
PMID:12046991 |
RGD:9698435 |
NCBI chr20:11,061,394...11,097,656
Ensembl chr20:11,061,430...11,097,600
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Mrc1 |
mannose receptor, C type 1 |
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ISO |
CTD Direct Evidence: marker/mechanism |
CTD |
PMID:36127783 |
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NCBI chr17:77,249,187...77,330,857
Ensembl chr17:77,249,187...77,330,857
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Muc1 |
mucin 1, cell surface associated |
severity |
ISO IMP IEP |
mRNA,protein:decreased expression:nasal mucosa |
RGD |
PMID:31425778 PMID:31425778 PMID:31425778 |
RGD:127345100, RGD:127345100, RGD:127345100 |
NCBI chr 2:174,635,989...174,640,738
Ensembl chr 2:174,635,995...174,640,733
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Muc1em1Cgen |
mucin 1, cell surface associated; TALEN induced mutant 1, Cgen |
severity |
IMP |
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RGD |
PMID:31425778 |
RGD:127345100 |
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Muc5ac |
mucin 5AC, oligomeric mucus/gel-forming |
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IEP |
mRNA, protein:increased expression:nasal cavity epithelium |
RGD |
PMID:22972875 |
RGD:7364746 |
NCBI chr 1:196,864,336...196,896,475
Ensembl chr 1:196,864,336...196,896,475
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Nod2 |
nucleotide-binding oligomerization domain containing 2 |
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ISO |
mRNA:increased expression:nasal mucosa (human) |
RGD |
PMID:23858718 |
RGD:8547523 |
NCBI chr19:18,382,369...18,422,817
Ensembl chr19:18,382,439...18,417,177
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Ocln |
occludin |
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ISO |
CTD Direct Evidence: marker/mechanism |
CTD |
PMID:33441633 |
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NCBI chr 2:31,657,217...31,707,466
Ensembl chr 2:31,657,220...31,764,150
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Pon1 |
paraoxonase 1 |
severity |
ISO |
protein:decreased activity:plasma (human) |
RGD |
PMID:23406590 |
RGD:8547583 |
NCBI chr 4:33,294,737...33,325,759
Ensembl chr 4:33,294,722...33,321,360
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Prkg1 |
protein kinase cGMP-dependent 1 |
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IEP |
protein:increased expression:nasal cavity epithelium |
RGD |
PMID:24012634 |
RGD:7775060 |
NCBI chr 1:228,409,605...229,638,794
Ensembl chr 1:228,408,947...229,639,080
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Ptgs2 |
prostaglandin-endoperoxide synthase 2 |
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ISO |
CTD Direct Evidence: marker/mechanism |
CTD |
PMID:16979129 |
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NCBI chr13:62,163,936...62,172,193
Ensembl chr13:62,163,932...62,172,188
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RT1-M3-1 |
RT1 class Ib, locus M3, gene 1 |
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ISO |
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RGD |
PMID:20487636 |
RGD:5144132 |
NCBI chr20:1,323,976...1,328,126
Ensembl chr20:1,287,521...1,328,117
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Scgb1a1 |
secretoglobin family 1A member 1 |
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ISO |
mRNA:decreased expression:nasal mucosa, lung |
RGD |
PMID:17882576 |
RGD:5144135 |
NCBI chr 1:205,977,060...205,980,610
Ensembl chr 1:205,977,060...205,980,610
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Scgb3a2 |
secretoglobin, family 3A, member 2 |
susceptibility |
ISO |
DNA:SNP: :rs7726552 (human) |
RGD |
PMID:21410962 |
RGD:5144225 |
NCBI chr18:35,932,840...35,935,762
Ensembl chr18:35,932,840...35,935,762
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Serpine1 |
serpin family E member 1 |
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ISO |
mRNA:increased expression:nasal mucosa (mouse) |
RGD |
PMID:21339035 |
RGD:8547809 |
NCBI chr12:19,601,272...19,611,657
Ensembl chr12:19,601,272...19,611,657
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Tacr1 |
tachykinin receptor 1 |
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IEP |
mRNA:increased expression:nasal mucosa |
RGD |
PMID:12768696 |
RGD:5147835 |
NCBI chr 4:114,920,844...115,089,733
Ensembl chr 4:114,920,844...115,089,733
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Tgfb1 |
transforming growth factor, beta 1 |
treatment |
IEP |
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RGD |
PMID:31368266 |
RGD:14995445 |
NCBI chr 1:81,196,532...81,212,848
Ensembl chr 1:81,196,532...81,212,847
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Tlr2 |
toll-like receptor 2 |
severity |
ISO |
DNA:polymorphism:cds:p.R753Q(human) protein:increased expression:neutrophil: mRNA:decreased expression:nasal mucosa: |
RGD |
PMID:22402138 PMID:22555057 PMID:18381801 PMID:18219831 |
RGD:7800732, RGD:8552993, RGD:8552972, RGD:7800742 |
NCBI chr 2:169,200,620...169,206,819
Ensembl chr 2:169,197,419...169,206,630
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Tlr4 |
toll-like receptor 4 |
severity treatment susceptibility no_association |
ISO |
DNA:polymorphism:cds:p.D299G(human) protein:increased expression:nasal lavage,leukocyte, bone marrow: protein:decreased expression:nasal mucosa: DNA:SNP: :rs1927911(human) DNA:polymorphism: :4216G>C(human) |
RGD |
PMID:22402138 PMID:22555057 PMID:22577387 PMID:17069098 PMID:23639307 PMID:19763595 More...
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RGD:7800732, RGD:8552993, RGD:7800740, RGD:7800738, RGD:7800736, RGD:4145354 |
NCBI chr 5:80,145,867...80,159,501
Ensembl chr 5:80,145,826...80,159,628
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Tlr9 |
toll-like receptor 9 |
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ISO |
protein:decreased expression:nasal mucosa: |
RGD |
PMID:22577387 |
RGD:7800740 |
NCBI chr 8:106,864,680...106,868,796
Ensembl chr 8:106,864,680...106,868,796
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G |
Cyp2c6 |
cytochrome P450, family 2, subfamily C, polypeptide 6 |
treatment |
ISO |
associated with Eosinophilic Esophagitis; DNA:polymorphisms:: |
RGD |
PMID:26416193 |
RGD:11352743 |
NCBI chr 1:237,938,521...237,976,238
Ensembl chr 1:237,693,094...238,057,596
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G |
Il3 |
interleukin 3 |
susceptibility |
ISO |
DNA:SNP: :rs40401(human) |
RGD |
PMID:23953855 |
RGD:13506915 |
NCBI chr10:38,405,716...38,408,066
Ensembl chr10:38,405,716...38,408,066
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G |
Ager |
advanced glycosylation end product-specific receptor |
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ISO |
DNA:SNP:promoter:-374T>A (human) |
RGD |
PMID:22114731 |
RGD:8695981 |
NCBI chr20:4,148,150...4,151,361
Ensembl chr20:4,147,890...4,151,078
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G |
Ccl19 |
C-C motif chemokine ligand 19 |
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ISO |
associated with Neutropenia;mRNA:increased expression:lung |
RGD |
PMID:19783686 |
RGD:5130908 |
NCBI chr 5:56,963,364...56,965,308
Ensembl chr 5:56,963,364...56,965,308
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Ccr7 |
C-C motif chemokine receptor 7 |
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ISO |
associated with Neutropenia |
RGD |
PMID:19783686 |
RGD:5130908 |
NCBI chr10:84,098,193...84,108,309
Ensembl chr10:84,097,381...84,108,309
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G |
Cd209d |
CD209d molecule |
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ISO |
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RGD |
PMID:21381282 |
RGD:5131183 |
NCBI chr12:1,891,109...1,897,559
Ensembl chr12:1,891,113...1,901,171
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G |
Cftr |
CF transmembrane conductance regulator |
severity |
ISO |
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RGD |
PMID:22135344 |
RGD:35673332 |
NCBI chr 4:46,561,269...46,728,759
Ensembl chr 4:46,560,885...46,728,756
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G |
Clec1a |
C-type lectin domain family 1, member A |
susceptibility |
ISO |
ClinVar Annotator: match by term: Aspergillosis, susceptibility to CTD Direct Evidence: marker/mechanism |
OMIM ClinVar CTD |
PMID:25741868 PMID:29489751 |
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NCBI chr 4:162,875,360...162,902,571
Ensembl chr 4:162,877,346...162,901,247
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G |
Clec7a |
C-type lectin domain containing 7A |
susceptibility |
ISO |
ClinVar Annotator: match by term: Aspergillosis, susceptibility to CTD Direct Evidence: marker/mechanism |
ClinVar OMIM CTD |
PMID:19864674 PMID:20807886 PMID:24033266 PMID:25741868 |
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NCBI chr 4:162,902,731...162,913,931
Ensembl chr 4:162,902,732...162,913,897
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G |
Crp |
C-reactive protein |
treatment |
ISO |
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RGD |
PMID:20879853 |
RGD:9495929 |
NCBI chr13:85,135,384...85,175,178
Ensembl chr13:85,124,977...85,175,178
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G |
Il15 |
interleukin 15 |
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ISO |
DNA:polymorphism (human) |
RGD |
PMID:16893395 |
RGD:4981337 |
NCBI chr19:25,640,025...25,706,818
Ensembl chr19:25,640,251...25,706,820
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G |
Mbl1 |
mannose binding lectin 1 |
susceptibility |
ISO |
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RGD |
PMID:20064561 |
RGD:8694071 |
NCBI chr16:17,029,146...17,035,187
Ensembl chr16:17,029,118...17,035,174
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G |
Mbl2 |
mannose binding lectin 2 |
susceptibility |
ISO |
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RGD |
PMID:20064561 |
RGD:8694071 |
NCBI chr 1:228,016,439...228,024,736
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S100b |
S100 calcium binding protein B |
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ISO |
DNA:SNP: :427C>T (human) |
RGD |
PMID:22114731 |
RGD:8695981 |
NCBI chr20:12,372,866...12,381,619
Ensembl chr20:12,372,881...12,394,743
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G |
Tlr1 |
toll-like receptor 1 |
susceptibility |
ISO |
DNA:SNPs: :p.R80T, p.N248S (human) |
RGD |
PMID:16461792 |
RGD:4889535 |
NCBI chr14:43,384,127...43,396,765
Ensembl chr14:43,384,932...43,397,125
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G |
Tlr2 |
toll-like receptor 2 |
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ISO |
mRNA:increased expression:lung |
RGD |
PMID:19781388 |
RGD:4145322 |
NCBI chr 2:169,200,620...169,206,819
Ensembl chr 2:169,197,419...169,206,630
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G |
Tlr6 |
toll-like receptor 6 |
susceptibility |
ISO |
DNA:SNP: :p.S249P (human) |
RGD |
PMID:16461792 |
RGD:4889535 |
NCBI chr14:43,362,164...43,374,500
Ensembl chr14:43,362,164...43,375,685
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Ace |
angiotensin I converting enzyme |
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ISO |
associated with Cerebrovascular Accident |
RGD |
PMID:14990394 |
RGD:4140926 |
NCBI chr10:90,910,316...90,930,437
Ensembl chr10:90,910,316...90,931,131
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G |
Cxcl1 |
C-X-C motif chemokine ligand 1 |
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IEP |
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RGD |
PMID:19515386 |
RGD:4891456 |
NCBI chr14:17,193,364...17,195,143
Ensembl chr14:17,193,365...17,195,215
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G |
Cxcl2 |
C-X-C motif chemokine ligand 2 |
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IEP |
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RGD |
PMID:19515386 |
RGD:4891456 |
NCBI chr14:17,181,030...17,183,075
Ensembl chr14:17,181,062...17,183,075
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G |
Edn1 |
endothelin 1 |
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IEP |
protein:increased secretion:plasma (rat) |
RGD |
PMID:19262391 |
RGD:4145069 |
NCBI chr17:22,454,924...22,460,812
Ensembl chr17:22,454,420...22,460,885
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G |
Il1a |
interleukin 1 alpha |
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IEP |
protein:increased expression:Bronchoalveolar Lavage Fluid |
RGD |
PMID:18042282 |
RGD:4142854 |
NCBI chr 3:116,526,601...116,537,055
Ensembl chr 3:116,526,604...116,536,822
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G |
Nos2 |
nitric oxide synthase 2 |
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ISO |
CTD Direct Evidence: marker/mechanism |
CTD |
PMID:15607125 |
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NCBI chr10:63,815,308...63,851,208
Ensembl chr10:63,815,308...63,851,210
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G |
Tnf |
tumor necrosis factor |
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IEP |
protein:increased expression:Bronchoalveolar Lavage Fluid |
RGD |
PMID:18042282 |
RGD:4142854 |
NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629
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G |
Marco |
macrophage receptor with collagenous structure |
disease_progression |
ISO |
association with Cryptococcal neoformans infection. |
RGD |
PMID:28298522 |
RGD:41412191 |
NCBI chr13:31,616,278...31,648,521
Ensembl chr13:31,616,278...31,648,521
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G |
Abcc1 |
ATP binding cassette subfamily C member 1 |
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ISO |
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RGD |
PMID:11238654 |
RGD:5128828 |
NCBI chr10:528,961...655,179
Ensembl chr10:531,812...655,114
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G |
Ace2 |
angiotensin converting enzyme 2 |
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ISO |
associated with Pseudomonas Infections;mRNA, protein:altered expression, altered activity:lung (mouse) |
RGD |
PMID:31645418 |
RGD:40818279 |
NCBI chr X:30,293,597...30,340,961
Ensembl chr X:30,293,589...30,340,977
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G |
Ager |
advanced glycosylation end product-specific receptor |
severity |
ISO |
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RGD |
PMID:21629785 |
RGD:6767559 |
NCBI chr20:4,148,150...4,151,361
Ensembl chr20:4,147,890...4,151,078
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G |
C3 |
complement C3 |
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ISO |
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RGD |
PMID:16014897 |
RGD:5129508 |
NCBI chr 9:2,087,437...2,114,366
Ensembl chr 9:2,087,437...2,114,429
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G |
C3ar1 |
complement C3a receptor 1 |
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ISO |
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RGD |
PMID:16461429 |
RGD:5129690 |
NCBI chr 4:156,074,747...156,084,680
Ensembl chr 4:156,075,389...156,084,701
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G |
C5 |
complement C5 |
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ISO |
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RGD |
PMID:17975174 |
RGD:5129707 |
NCBI chr 3:18,270,696...18,361,994
Ensembl chr 3:18,270,696...18,361,994
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G |
Cat |
catalase |
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IDA |
protein:decreased expression:lung, plasma |
RGD |
PMID:19842849 |
RGD:5130748 |
NCBI chr 3:89,842,393...89,874,577
Ensembl chr 3:89,842,399...89,874,478
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G |
Ccl19 |
C-C motif chemokine ligand 19 |
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ISO |
mRNA, protein:increased expression:lung |
RGD |
PMID:20176793 |
RGD:5130918 |
NCBI chr 5:56,963,364...56,965,308
Ensembl chr 5:56,963,364...56,965,308
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G |
Ccl2 |
C-C motif chemokine ligand 2 |
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ISO |
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RGD |
PMID:20042590 |
RGD:4891443 |
NCBI chr10:67,005,424...67,007,222
Ensembl chr10:67,005,424...67,007,226
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G |
Ccl4 |
C-C motif chemokine ligand 4 |
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ISO |
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RGD |
PMID:20483921 |
RGD:5130905 |
NCBI chr10:68,466,394...68,468,229
Ensembl chr10:68,452,052...68,468,231
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G |
Ccr2 |
C-C motif chemokine receptor 2 |
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ISO |
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RGD |
PMID:20042590 |
RGD:4891443 |
NCBI chr 8:123,734,465...123,742,483
Ensembl chr 8:123,734,430...123,742,100
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G |
Ccr7 |
C-C motif chemokine receptor 7 |
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ISO |
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RGD |
PMID:20176793 |
RGD:5130918 |
NCBI chr10:84,098,193...84,108,309
Ensembl chr10:84,097,381...84,108,309
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G |
Cd14 |
CD14 molecule |
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ISO |
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RGD |
PMID:16210672 |
RGD:4144197 |
NCBI chr18:28,335,522...28,337,383
Ensembl chr18:28,335,340...28,337,261
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G |
Cd40 |
CD40 molecule |
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ISO |
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RGD |
PMID:20102413 |
RGD:5132268 |
NCBI chr 3:153,790,372...153,805,279
Ensembl chr 3:153,790,449...153,805,534
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G |
Cd80 |
Cd80 molecule |
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ISO |
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RGD |
PMID:20949109 |
RGD:4892562 |
NCBI chr11:62,254,543...62,293,414
Ensembl chr11:62,254,624...62,292,030
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G |
Chuk |
component of inhibitor of nuclear factor kappa B kinase complex |
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ISO |
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RGD |
PMID:18643924 |
RGD:5133701 |
NCBI chr 1:242,959,539...242,995,066
Ensembl chr 1:242,959,760...242,995,065
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G |
Csf3 |
colony stimulating factor 3 |
disease_progression treatment |
ISO |
associated with Peritonitis; |
RGD |
PMID:21373266 PMID:12352049 |
RGD:5133733, RGD:11039437 |
NCBI chr10:83,660,787...83,664,569
Ensembl chr10:83,661,207...83,663,603
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G |
Csf3r |
colony stimulating factor 3 receptor |
disease_progression |
ISO |
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RGD |
PMID:17185469 |
RGD:5133739 |
NCBI chr 5:138,298,605...138,318,224
Ensembl chr 5:138,301,506...138,317,881
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G |
Cxcl1 |
C-X-C motif chemokine ligand 1 |
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ISO IEP |
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RGD |
PMID:21723409 PMID:11052817 |
RGD:5135062, RGD:5135234 |
NCBI chr14:17,193,364...17,195,143
Ensembl chr14:17,193,365...17,195,215
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G |
Cxcl10 |
C-X-C motif chemokine ligand 10 |
severity |
ISO |
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RGD |
PMID:16299319 PMID:15618188 |
RGD:5135458, RGD:5135459 |
NCBI chr14:15,704,772...15,706,969
Ensembl chr14:15,704,758...15,706,975
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G |
Cxcl11 |
C-X-C motif chemokine ligand 11 |
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ISO |
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RGD |
PMID:15618188 |
RGD:5135459 |
NCBI chr14:15,689,432...15,692,207
Ensembl chr14:15,689,424...15,692,271
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G |
Cxcl2 |
C-X-C motif chemokine ligand 2 |
severity |
ISO IEP |
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RGD |
PMID:19239431 PMID:11052817 PMID:21723409 |
RGD:5135065, RGD:5135234, RGD:5135062 |
NCBI chr14:17,181,030...17,183,075
Ensembl chr14:17,181,062...17,183,075
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G |
Cxcl3 |
C-X-C motif chemokine ligand 3 |
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IEP |
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RGD |
PMID:11052817 |
RGD:5135234 |
NCBI chr14:17,287,727...17,289,451
Ensembl chr14:17,270,146...17,289,511
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G |
Cxcl6 |
C-X-C motif chemokine ligand 6 |
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ISO |
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RGD |
PMID:19846873 |
RGD:4145490 |
NCBI chr14:17,310,790...17,312,250
Ensembl chr14:17,310,426...17,313,093
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G |
Cxcl9 |
C-X-C motif chemokine ligand 9 |
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ISO |
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RGD |
PMID:15618188 |
RGD:5135459 |
NCBI chr14:15,722,868...15,727,779
Ensembl chr14:15,722,908...15,728,435
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G |
Cxcr3 |
C-X-C motif chemokine receptor 3 |
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ISO |
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RGD |
PMID:15618188 |
RGD:5135459 |
NCBI chr X:66,844,318...66,846,969
Ensembl chr X:66,844,318...66,846,969
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G |
Cyp2j4 |
cytochrome P450, family 2, subfamily j, polypeptide 4 |
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IEP |
protein:decreased expression:lung |
RGD |
PMID:14766666 |
RGD:1625385 |
NCBI chr 5:111,179,981...111,207,490
Ensembl chr 5:111,178,703...111,244,794
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G |
Defb4 |
defensin beta 4 |
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ISO |
protein:increased expression:plasma |
RGD |
PMID:10213993 |
RGD:4892266 |
NCBI chr16:70,650,472...70,653,665
Ensembl chr16:70,650,472...70,653,665
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G |
Defb5 |
defensin beta 5 |
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ISO |
protein:increased expression:plasma |
RGD |
PMID:10213993 |
RGD:4892266 |
NCBI chr16:70,612,985...70,615,389
Ensembl chr16:70,613,146...70,615,467
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G |
F2 |
coagulation factor II, thrombin |
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IEP |
protein:increased expression:lung |
RGD |
PMID:21897338 |
RGD:6893486 |
NCBI chr 3:77,596,196...77,609,486
Ensembl chr 3:77,596,198...77,609,486
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G |
Fcgr2a |
Fc gamma receptor 2A |
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ISO |
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RGD |
PMID:17975174 |
RGD:5129707 |
NCBI chr13:83,280,782...83,297,535
Ensembl chr13:83,280,784...83,295,967
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G |
Foxp3 |
forkhead box P3 |
severity |
ISO |
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RGD |
PMID:25398094 |
RGD:38501102 |
NCBI chr X:14,908,494...14,924,994
Ensembl chr X:14,908,494...14,923,838
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G |
Gp1ba |
glycoprotein Ib platelet subunit alpha |
exacerbates |
ISO |
associated with Escherichia Coli Infections |
RGD |
PMID:27845343 |
RGD:42722624 |
NCBI chr10:55,352,938...55,355,804
Ensembl chr10:55,352,899...55,356,774
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G |
Grk2 |
G protein-coupled receptor kinase 2 |
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ISO |
mRNA:decreased expression:polymorphonuclear leukocyte |
RGD |
PMID:24465168 |
RGD:126848796 |
NCBI chr 1:201,580,823...201,601,580
Ensembl chr 1:201,581,480...201,601,582
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G |
Icam1 |
intercellular adhesion molecule 1 |
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ISO |
protein:increased expression:lung (mouse) |
RGD |
PMID:19846873 |
RGD:4145490 |
NCBI chr 8:19,553,063...19,565,438
Ensembl chr 8:19,553,645...19,565,438
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G |
Ifnar1 |
interferon alpha and beta receptor subunit 1 |
severity |
ISO |
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RGD |
PMID:19487810 PMID:19487810 |
RGD:5490274, RGD:5490274 |
NCBI chr11:30,725,774...30,752,227
Ensembl chr11:30,725,790...30,749,979
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G |
Ifng |
interferon gamma |
severity |
ISO |
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RGD |
PMID:25398094 |
RGD:38501102 |
NCBI chr 7:53,903,339...53,907,375
Ensembl chr 7:53,903,337...53,907,375
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G |
Il10 |
interleukin 10 |
severity |
ISO |
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RGD |
PMID:25398094 |
RGD:38501102 |
NCBI chr13:42,472,625...42,477,308
Ensembl chr13:42,472,839...42,477,313
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G |
Il15 |
interleukin 15 |
|
ISO |
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RGD |
PMID:17911627 |
RGD:5000754 |
NCBI chr19:25,640,025...25,706,818
Ensembl chr19:25,640,251...25,706,820
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G |
Il17a |
interleukin 17A |
severity |
ISO |
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RGD |
PMID:18802100 PMID:25398094 |
RGD:4889153, RGD:38501102 |
NCBI chr 9:23,144,402...23,147,889
Ensembl chr 9:23,144,402...23,147,889
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G |
Il18 |
interleukin 18 |
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ISO |
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RGD |
PMID:17664259 |
RGD:4889913 |
NCBI chr 8:50,904,630...50,932,887
Ensembl chr 8:50,906,960...50,932,887
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G |
Il1b |
interleukin 1 beta |
severity treatment |
ISO |
associated with Agranulocytosis |
RGD |
PMID:18596024 PMID:25398094 PMID:7546648 |
RGD:4143205, RGD:38501102, RGD:10755357 |
NCBI chr 3:116,577,005...116,583,386
Ensembl chr 3:116,577,010...116,583,415
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G |
Il1rl1 |
interleukin 1 receptor-like 1 |
treatment |
ISO IEP |
associated with Sepsis associated with Acinetobacter infectious disease |
RGD |
PMID:20959556 PMID:29508184 |
RGD:5144223, RGD:40818077 |
NCBI chr 9:42,661,694...42,727,266
Ensembl chr 9:42,697,192...42,727,256
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G |
Il1rn |
interleukin 1 receptor antagonist |
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ISO |
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RGD |
PMID:18596024 PMID:18322242 |
RGD:4143205, RGD:4143206 |
NCBI chr 3:7,111,567...7,127,451
Ensembl chr 3:7,111,550...7,127,445
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G |
Il22 |
interleukin 22 |
|
ISO |
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RGD |
PMID:21178015 |
RGD:5147404 |
NCBI chr 7:53,801,206...53,805,673
Ensembl chr 7:53,801,206...53,806,186
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G |
Il6 |
interleukin 6 |
severity |
ISO |
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RGD |
PMID:25398094 |
RGD:38501102 |
NCBI chr 4:5,214,602...5,219,178
Ensembl chr 4:5,213,394...5,219,178
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G |
Irak3 |
interleukin-1 receptor-associated kinase 3 |
|
ISO |
|
RGD |
PMID:28120642 PMID:20439918 |
RGD:34888234, RGD:36049799 |
NCBI chr 7:55,653,949...55,714,371
Ensembl chr 7:55,653,962...55,713,121
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G |
Irf1 |
interferon regulatory factor 1 |
|
ISO |
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RGD |
PMID:11854220 |
RGD:5128725 |
NCBI chr10:37,917,155...37,924,166
Ensembl chr10:37,916,670...37,924,166
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G |
Irf3 |
interferon regulatory factor 3 |
|
ISO |
|
RGD |
PMID:20720199 |
RGD:4891951 |
NCBI chr 1:95,479,966...95,484,926
Ensembl chr 1:95,479,821...95,484,935
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G |
Itgb3 |
integrin subunit beta 3 |
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IEP |
protein:increased expression:lung, neutrophil |
RGD |
PMID:15114484 |
RGD:4993468 |
NCBI chr10:89,509,917...89,564,679
Ensembl chr10:89,509,989...89,564,679
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G |
Lep |
leptin |
|
ISO |
|
RGD |
PMID:11937559 |
RGD:5128871 |
NCBI chr 4:57,661,127...57,675,262
Ensembl chr 4:57,661,131...57,675,262
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|
G |
Mapk8 |
mitogen-activated protein kinase 8 |
severity |
ISO |
associated with Escherichia Coli Infections |
RGD |
PMID:22514650 |
RGD:150340681 |
NCBI chr16:8,638,897...8,721,960
Ensembl chr16:8,638,924...8,721,981
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|
G |
Mbl2 |
mannose binding lectin 2 |
|
ISO |
Legionella Pneumonia; DNA:mutations:5' utr, exon:multiple (human) |
RGD |
PMID:18641104 |
RGD:4889477 |
NCBI chr 1:228,016,439...228,024,736
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G |
Mc1r |
melanocortin 1 receptor |
|
ISO |
|
RGD |
PMID:18304533 |
RGD:5687324 |
NCBI chr19:51,452,448...51,455,375
Ensembl chr19:51,453,239...51,454,192
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G |
Mmp9 |
matrix metallopeptidase 9 |
|
ISO |
protein:increased expression:bronchoalveolar lavage fluid |
RGD |
PMID:17202364 PMID:19535150 |
RGD:5130727, RGD:5129533 |
NCBI chr 3:153,684,158...153,692,118
Ensembl chr 3:153,683,858...153,692,120
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G |
Mpo |
myeloperoxidase |
|
ISO |
protein:increased activity:bronchoalveolar lavage Fluid: |
RGD |
PMID:11269653 |
RGD:5130992 |
NCBI chr10:72,594,883...72,608,862
Ensembl chr10:72,594,661...72,604,819
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G |
Nod1 |
nucleotide-binding oligomerization domain containing 1 |
|
ISO |
|
RGD |
PMID:19360122 |
RGD:5131449 |
NCBI chr 4:84,060,871...84,111,668
Ensembl chr 4:84,060,880...84,111,404
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G |
Nod2 |
nucleotide-binding oligomerization domain containing 2 |
|
ISO |
|
RGD |
PMID:19360122 |
RGD:5131449 |
NCBI chr19:18,382,369...18,422,817
Ensembl chr19:18,382,439...18,417,177
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G |
Pdpn |
podoplanin |
|
IEP |
protein:increased expression:lung |
RGD |
PMID:7864138 |
RGD:2292375 |
NCBI chr 5:155,601,691...155,635,656
Ensembl chr 5:155,601,691...155,635,656
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G |
Pecam1 |
platelet and endothelial cell adhesion molecule 1 |
|
IEP |
protein:decreased expression:lung |
RGD |
PMID:12524254 |
RGD:724645 |
NCBI chr10:91,590,521...91,652,279
Ensembl chr10:91,590,521...91,652,116
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G |
Pgf |
placental growth factor |
|
ISO |
protein:increased expression:plasma |
RGD |
PMID:16702604 |
RGD:6483601 |
NCBI chr 6:104,816,102...104,826,685
Ensembl chr 6:104,816,104...104,826,685
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G |
Pten |
phosphatase and tensin homolog |
ameliorates |
ISO |
myeloid knockout |
RGD |
PMID:21527775 |
RGD:127285594 |
NCBI chr 1:230,630,443...230,697,070
Ensembl chr 1:230,630,338...230,696,838
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G |
Ripk3 |
receptor-interacting serine-threonine kinase 3 |
ameliorates |
ISO |
|
RGD |
PMID:28387756 |
RGD:127229944 |
NCBI chr15:29,283,153...29,292,107
Ensembl chr15:29,283,145...29,292,121
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G |
Rorc |
RAR-related orphan receptor C |
severity |
ISO |
|
RGD |
PMID:25398094 |
RGD:38501102 |
NCBI chr 2:182,009,707...182,034,910
Ensembl chr 2:182,009,286...182,034,907
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G |
Serpine1 |
serpin family E member 1 |
severity |
ISO |
|
RGD |
PMID:17032919 |
RGD:4144840 |
NCBI chr12:19,601,272...19,611,657
Ensembl chr12:19,601,272...19,611,657
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G |
Sftpa1 |
surfactant protein A1 |
|
IEP |
protein:increased expression:lung |
RGD |
PMID:12169586 |
RGD:4143464 |
NCBI chr16:17,008,180...17,011,686
Ensembl chr16:17,008,180...17,011,685
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G |
Sftpb |
surfactant protein B |
|
ISO IEP |
associated with Cystic Fibrosis;protein:increased expression:lung |
RGD |
PMID:15271694 PMID:12169586 |
RGD:4143403, RGD:4143464 |
NCBI chr 4:104,359,303...104,368,439
Ensembl chr 4:104,359,396...104,368,436
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G |
Sftpc |
surfactant protein C |
|
ISO IEP |
|
RGD |
PMID:18566429 PMID:12169586 |
RGD:4144114, RGD:4143464 |
NCBI chr15:45,596,565...45,599,615
Ensembl chr15:45,596,574...45,610,777
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G |
Sftpd |
surfactant protein D |
|
ISO IEP |
associated with Cystic Fibrosis;protein:decreased expression:lung protein:increased expression:lung |
RGD |
PMID:15271694 PMID:12169586 |
RGD:4143403, RGD:4143464 |
NCBI chr16:17,046,491...17,058,968
Ensembl chr16:17,046,483...17,059,927
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G |
Stat3 |
signal transducer and activator of transcription 3 |
|
ISO |
|
RGD |
PMID:18192501 |
RGD:6892945 |
NCBI chr10:85,811,206...85,863,057
Ensembl chr10:85,811,218...85,863,057
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G |
Tgfb1 |
transforming growth factor, beta 1 |
severity |
ISO |
|
RGD |
PMID:25398094 |
RGD:38501102 |
NCBI chr 1:81,196,532...81,212,848
Ensembl chr 1:81,196,532...81,212,847
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G |
Tlr2 |
toll-like receptor 2 |
|
ISO IDA |
|
RGD |
PMID:18768871 PMID:19844782 |
RGD:4145337, RGD:4889533 |
NCBI chr 2:169,200,620...169,206,819
Ensembl chr 2:169,197,419...169,206,630
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G |
Tlr4 |
toll-like receptor 4 |
|
ISO |
|
RGD |
PMID:20650991 PMID:16210672 |
RGD:4144172, RGD:4144197 |
NCBI chr 5:80,145,867...80,159,501
Ensembl chr 5:80,145,826...80,159,628
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G |
Tlr5 |
toll-like receptor 5 |
|
ISO |
|
RGD |
PMID:19801452 |
RGD:5129503 |
NCBI chr13:94,634,778...94,658,992
Ensembl chr13:94,634,801...94,657,738
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G |
Tlr6 |
toll-like receptor 6 |
|
IDA |
|
RGD |
PMID:19844782 |
RGD:4889533 |
NCBI chr14:43,362,164...43,374,500
Ensembl chr14:43,362,164...43,375,685
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G |
Tlr9 |
toll-like receptor 9 |
|
ISO |
|
RGD |
PMID:20360853 |
RGD:5130719 |
NCBI chr 8:106,864,680...106,868,796
Ensembl chr 8:106,864,680...106,868,796
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G |
Tnf |
tumor necrosis factor |
disease_progression treatment severity |
ISO |
associated with Agranulocytosis |
RGD |
PMID:10650487 PMID:7546648 PMID:9310939 PMID:12958055 |
RGD:4143476, RGD:10755357, RGD:10450564, RGD:10449451 |
NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629
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G |
Tnfrsf1a |
TNF receptor superfamily member 1A |
|
ISO |
protein:increased expression:serum (mouse) |
RGD |
PMID:19842848 |
RGD:5131429 |
NCBI chr 4:158,150,815...158,163,592
Ensembl chr 4:158,150,820...158,163,591
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G |
Tnfrsf1b |
TNF receptor superfamily member 1B |
|
ISO |
protein:increased expression:serum (mouse) |
RGD |
PMID:19842848 |
RGD:5131429 |
NCBI chr 5:157,070,642...157,104,216
Ensembl chr 5:157,070,642...157,104,206
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G |
Trem1 |
triggering receptor expressed on myeloid cells 1 |
severity ameliorates |
ISO IDA |
|
RGD |
PMID:24465168 PMID:16960786 PMID:22996209 |
RGD:126848796, RGD:127229902, RGD:126925987 |
NCBI chr 9:12,763,819...12,779,285
Ensembl chr 9:12,763,819...12,779,203
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G |
Zc3h12a |
zinc finger CCCH type containing 12A |
|
ISO |
associated with Pseudomonas Infections |
RGD |
PMID:29695841 |
RGD:39938967 |
NCBI chr 5:137,376,562...137,385,351
Ensembl chr 5:137,376,564...137,385,351
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G |
Adrb2 |
adrenoceptor beta 2 |
|
ISO |
|
RGD |
PMID:17687719 |
RGD:4145098 |
NCBI chr18:55,642,459...55,644,501
Ensembl chr18:55,502,903...55,644,512
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G |
Ccl11 |
C-C motif chemokine ligand 11 |
severity |
ISO |
protein:increased expression:nasal mucus associated with Respiratory Syncytial Virus Infections |
RGD |
PMID:17297249 PMID:15681407 |
RGD:4145460, RGD:4145415 |
NCBI chr10:67,028,328...67,032,929
Ensembl chr10:67,028,328...67,032,926
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G |
Cd40 |
CD40 molecule |
|
ISO |
|
RGD |
PMID:19470255 |
RGD:5132271 |
NCBI chr 3:153,790,372...153,805,279
Ensembl chr 3:153,790,449...153,805,534
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G |
Cd86 |
CD86 molecule |
|
ISO |
protein:decreased expression:myeloid dendritic cell (mouse) |
RGD |
PMID:20046053 |
RGD:4892291 |
NCBI chr11:64,142,193...64,200,816
Ensembl chr11:64,163,828...64,200,818
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G |
Crp |
C-reactive protein |
severity |
ISO |
|
RGD |
PMID:21284715 |
RGD:5131282 |
NCBI chr13:85,135,384...85,175,178
Ensembl chr13:85,124,977...85,175,178
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G |
Cysltr1 |
cysteinyl leukotriene receptor 1 |
|
ISO |
associated with Pneumovirus Infections |
RGD |
PMID:16337014 |
RGD:4843953 |
NCBI chr X:71,661,421...71,690,012
Ensembl chr X:71,663,821...71,690,121
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G |
Il17a |
interleukin 17A |
susceptibility |
ISO |
DNA:SNP:promoter:rs2275913 (human) |
RGD |
PMID:20437253 |
RGD:4889139 |
NCBI chr 9:23,144,402...23,147,889
Ensembl chr 9:23,144,402...23,147,889
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G |
Il1b |
interleukin 1 beta |
|
ISO |
protein:increased expression:lung |
RGD |
PMID:8608647 |
RGD:4143192 |
NCBI chr 3:116,577,005...116,583,386
Ensembl chr 3:116,577,010...116,583,415
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G |
Il1rn |
interleukin 1 receptor antagonist |
|
ISO |
protein:increased expression:lung |
RGD |
PMID:8608647 |
RGD:4143192 |
NCBI chr 3:7,111,567...7,127,451
Ensembl chr 3:7,111,550...7,127,445
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G |
Muc5b |
mucin 5B, oligomeric mucus/gel-forming |
|
ISO |
DNA:polymorphisms:promoter:rs885454,rs17235353, rs7115457 (human) |
RGD |
PMID:15709052 |
RGD:7349353 |
NCBI chr 1:196,916,861...196,948,830
Ensembl chr 1:196,916,825...196,949,250
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G |
Ace |
angiotensin I converting enzyme |
|
IMP |
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RGD |
PMID:17097496 |
RGD:4140933 |
NCBI chr10:90,910,316...90,930,437
Ensembl chr10:90,910,316...90,931,131
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G |
Adora2a |
adenosine A2a receptor |
|
ISO |
|
RGD |
PMID:19766783 |
RGD:4890362 |
NCBI chr20:13,315,848...13,333,386
Ensembl chr20:13,315,853...13,333,386
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G |
Ccl17 |
C-C motif chemokine ligand 17 |
|
ISO |
|
RGD |
PMID:18785972 |
RGD:4145604 |
NCBI chr19:10,202,128...10,203,903
Ensembl chr19:10,202,128...10,203,819
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G |
Ccl2 |
C-C motif chemokine ligand 2 |
|
IMP |
|
RGD |
PMID:14611812 |
RGD:2307195 |
NCBI chr10:67,005,424...67,007,222
Ensembl chr10:67,005,424...67,007,226
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G |
Ccl22 |
C-C motif chemokine ligand 22 |
|
ISO |
|
RGD |
PMID:20628341 |
RGD:4891471 |
NCBI chr19:10,257,602...10,264,373
Ensembl chr19:10,257,601...10,264,400
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G |
Ccl5 |
C-C motif chemokine ligand 5 |
|
IEP IMP |
mRNA:increased expression:lung (rat) |
RGD |
PMID:19840961 PMID:14611812 |
RGD:4889978, RGD:2307195 |
NCBI chr10:68,322,826...68,327,380
Ensembl chr10:68,322,829...68,327,377
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G |
Ccl7 |
C-C motif chemokine ligand 7 |
|
IEP |
protein:increased expression:bronchoalveolar Lavage fluid |
RGD |
PMID:22215510 |
RGD:6483763 |
NCBI chr10:67,016,446...67,018,296
Ensembl chr10:67,016,446...67,018,303
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G |
Ccr2 |
C-C motif chemokine receptor 2 |
|
ISO |
mRNA:increased expression:trachea: |
RGD |
PMID:11518728 |
RGD:4145124 |
NCBI chr 8:123,734,465...123,742,483
Ensembl chr 8:123,734,430...123,742,100
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G |
Cd86 |
CD86 molecule |
|
IMP |
|
RGD |
PMID:11266944 |
RGD:2307206 |
NCBI chr11:64,142,193...64,200,816
Ensembl chr11:64,163,828...64,200,818
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G |
Csf2 |
colony stimulating factor 2 |
|
IEP |
associated with Respiratory Aspiration;protein:increased expression:serum |
RGD |
PMID:18557728 |
RGD:2317286 |
NCBI chr10:38,386,945...38,388,926
Ensembl chr10:38,386,945...38,389,199
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G |
Cxcl10 |
C-X-C motif chemokine ligand 10 |
|
ISO |
protein:increased expression:respiratory system fluid/secretion |
RGD |
PMID:16709871 PMID:12097412 PMID:12097412 |
RGD:5135441, RGD:5135451, RGD:5135451 |
NCBI chr14:15,704,772...15,706,969
Ensembl chr14:15,704,758...15,706,975
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G |
Cxcl11 |
C-X-C motif chemokine ligand 11 |
|
ISO |
protein:increased expression:respiratory system fluid/secretion |
RGD |
PMID:12097412 PMID:12097412 |
RGD:5135451, RGD:5135451 |
NCBI chr14:15,689,432...15,692,207
Ensembl chr14:15,689,424...15,692,271
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G |
Cxcl9 |
C-X-C motif chemokine ligand 9 |
|
ISO |
protein:increased expression:respiratory system fluid/secretion |
RGD |
PMID:16709871 PMID:12097412 PMID:12097412 |
RGD:5135441, RGD:5135451, RGD:5135451 |
NCBI chr14:15,722,868...15,727,779
Ensembl chr14:15,722,908...15,728,435
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G |
Cxcr3 |
C-X-C motif chemokine receptor 3 |
|
ISO |
|
RGD |
PMID:16709871 PMID:12097412 |
RGD:5135441, RGD:5135451 |
NCBI chr X:66,844,318...66,846,969
Ensembl chr X:66,844,318...66,846,969
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G |
Edn1 |
endothelin 1 |
|
ISO |
human gene in a rat model |
RGD |
PMID:9595474 |
RGD:8662402 |
NCBI chr17:22,454,924...22,460,812
Ensembl chr17:22,454,420...22,460,885
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G |
Foxp3 |
forkhead box P3 |
|
IEP |
mRNA:increased expression:lung |
RGD |
PMID:19840961 |
RGD:4889978 |
NCBI chr X:14,908,494...14,924,994
Ensembl chr X:14,908,494...14,923,838
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G |
Gzmb |
granzyme B |
|
ISO |
|
RGD |
PMID:19737140 |
RGD:5135518 |
NCBI chr15:30,343,352...30,346,814
Ensembl chr15:30,173,603...30,346,814
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G |
Hmox1 |
heme oxygenase 1 |
|
ISO |
|
RGD |
PMID:12973103 |
RGD:4145412 |
NCBI chr19:13,466,287...13,474,082
Ensembl chr19:13,467,244...13,474,079
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G |
Ifng |
interferon gamma |
|
ISO |
CTD Direct Evidence: therapeutic |
CTD |
PMID:16137903 |
|
NCBI chr 7:53,903,339...53,907,375
Ensembl chr 7:53,903,337...53,907,375
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G |
Il13 |
interleukin 13 |
|
ISO |
protein:increased expression:bronchoalveolar lavage fluid |
RGD |
PMID:17182591 |
RGD:4146242 |
NCBI chr10:37,790,130...37,792,687
Ensembl chr10:37,790,130...37,792,737
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G |
Il13ra1 |
interleukin 13 receptor subunit alpha 1 |
|
ISO |
|
RGD |
PMID:17182591 |
RGD:4146242 |
NCBI chr X:115,348,822...115,408,682
Ensembl chr X:115,348,860...115,408,681 Ensembl chr11:115,348,860...115,408,681
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G |
Il13ra2 |
interleukin 13 receptor subunit alpha 2 |
|
ISO |
|
RGD |
PMID:17182591 |
RGD:4146242 |
NCBI chr X:111,002,590...111,074,053
Ensembl chr X:111,002,592...111,072,381
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G |
Il17a |
interleukin 17A |
|
ISO |
mRNA:increased expression:trachea |
RGD |
PMID:20393404 |
RGD:4143277 |
NCBI chr 9:23,144,402...23,147,889
Ensembl chr 9:23,144,402...23,147,889
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G |
Il1rn |
interleukin 1 receptor antagonist |
|
ISO |
protein:increased expression:lung |
RGD |
PMID:11889437 |
RGD:4143176 |
NCBI chr 3:7,111,567...7,127,451
Ensembl chr 3:7,111,550...7,127,445
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G |
Il4 |
interleukin 4 |
|
IEP |
protein:increased expression:serum |
RGD |
PMID:18557728 |
RGD:2317286 |
NCBI chr10:37,771,203...37,776,750
Ensembl chr10:37,771,203...37,776,750
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G |
Il6 |
interleukin 6 |
|
ISO |
|
RGD |
PMID:20393404 |
RGD:4143277 |
NCBI chr 4:5,214,602...5,219,178
Ensembl chr 4:5,213,394...5,219,178
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G |
Mbl2 |
mannose binding lectin 2 |
resistance |
ISO |
DNA:transversion:5' utr:-290C>G rs7096206 (human) |
RGD |
PMID:19104434 |
RGD:4889456 |
NCBI chr 1:228,016,439...228,024,736
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G |
Mmp9 |
matrix metallopeptidase 9 |
|
ISO |
protein:increased expression, increased activity:bronchoalveolar lavage fluid |
RGD |
PMID:20417130 |
RGD:5130759 |
NCBI chr 3:153,684,158...153,692,118
Ensembl chr 3:153,683,858...153,692,120
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G |
Muc1 |
mucin 1, cell surface associated |
|
ISO |
protein:increased expression:serum |
RGD |
PMID:16969297 |
RGD:5131273 |
NCBI chr 2:174,635,989...174,640,738
Ensembl chr 2:174,635,995...174,640,733
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G |
Nod2 |
nucleotide-binding oligomerization domain containing 2 |
|
ISO |
|
RGD |
PMID:18158963 |
RGD:5131450 |
NCBI chr19:18,382,369...18,422,817
Ensembl chr19:18,382,439...18,417,177
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G |
Nos2 |
nitric oxide synthase 2 |
|
ISO |
associated with lung transplantation; protein:increased expression:lung |
RGD |
PMID:11112135 |
RGD:4892082 |
NCBI chr10:63,815,308...63,851,208
Ensembl chr10:63,815,308...63,851,210
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G |
Nos3 |
nitric oxide synthase 3 |
|
IEP |
protein:increased expression:lung |
RGD |
PMID:15136885 |
RGD:4892068 |
NCBI chr 4:10,793,834...10,814,170
Ensembl chr 4:10,793,834...10,814,166
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G |
Scgb1a1 |
secretoglobin family 1A member 1 |
|
ISO |
associated with lung transplantation; protein:decreased expression:serum,bronchoalveolar lavage |
RGD |
PMID:11981419 |
RGD:5147386 |
NCBI chr 1:205,977,060...205,980,610
Ensembl chr 1:205,977,060...205,980,610
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G |
Sftpd |
surfactant protein D |
|
ISO |
|
RGD |
PMID:18347569 |
RGD:4143500 |
NCBI chr16:17,046,491...17,058,968
Ensembl chr16:17,046,483...17,059,927
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G |
Tlr9 |
toll-like receptor 9 |
|
ISO |
DNA:SNPs:promoter, 3' utr:g.-1485C>T (rs187084), rs352162 (human) |
RGD |
PMID:20227302 |
RGD:5130722 |
NCBI chr 8:106,864,680...106,868,796
Ensembl chr 8:106,864,680...106,868,796
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|
G |
Cyp1a1 |
cytochrome P450, family 1, subfamily a, polypeptide 1 |
|
ISO |
DNA:polymorphism (human) |
RGD |
PMID:14593914 |
RGD:4889126 |
NCBI chr 8:58,096,021...58,102,130
Ensembl chr 8:58,096,077...58,102,125
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|
G |
Egr1 |
early growth response 1 |
|
ISO |
|
RGD |
PMID:17384085 |
RGD:5132266 |
NCBI chr18:26,462,967...26,466,766
Ensembl chr18:26,462,981...26,466,766
|
|
G |
Hdac2 |
histone deacetylase 2 |
treatment |
IEP |
|
RGD |
PMID:22708526 |
RGD:9590258 |
NCBI chr20:40,548,244...40,571,609
Ensembl chr20:40,548,250...40,571,609
|
|
G |
Ifng |
interferon gamma |
resistance |
ISO |
|
RGD |
PMID:20953328 |
RGD:4145525 |
NCBI chr 7:53,903,339...53,907,375
Ensembl chr 7:53,903,337...53,907,375
|
|
|
G |
Ccl5 |
C-C motif chemokine ligand 5 |
|
ISO |
protein:increased secretion:serum (human) |
RGD |
PMID:20350425 |
RGD:4892019 |
NCBI chr10:68,322,826...68,327,380
Ensembl chr10:68,322,829...68,327,377
|
|
G |
Cxcr2 |
C-X-C motif chemokine receptor 2 |
disease_progression |
ISO |
associated with Plague |
RGD |
PMID:21356370 |
RGD:5134954 |
NCBI chr 9:75,729,493...75,735,868
Ensembl chr 9:75,729,115...75,739,425
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|
G |
Mbl2 |
mannose binding lectin 2 |
|
ISO |
associated with Down Syndrome; protein:decreased secretion:serum (human) |
RGD |
PMID:19804807 |
RGD:4889483 |
NCBI chr 1:228,016,439...228,024,736
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|
|
G |
Cd274 |
CD274 molecule |
|
ISO |
mRNA:increased expression:lung |
RGD |
PMID:26378990 |
RGD:41412180 |
NCBI chr 1:227,116,674...227,137,379
Ensembl chr 1:227,116,649...227,134,450
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|
G |
Pdcd1 |
programmed cell death 1 |
|
ISO |
mRNA:increased expression:lung |
RGD |
PMID:26378990 |
RGD:41412180 |
NCBI chr 9:94,418,786...94,431,945
Ensembl chr 9:94,418,791...94,431,937
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|
G |
Pik3cd |
phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit delta |
severity |
ISO |
|
RGD |
PMID:29893841 |
RGD:40890270 |
NCBI chr 5:160,094,952...160,142,962
Ensembl chr 5:160,094,952...160,120,930
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|
|
G |
Ccl11 |
C-C motif chemokine ligand 11 |
|
ISO |
|
RGD |
PMID:11991282 |
RGD:4145442 |
NCBI chr10:67,028,328...67,032,929
Ensembl chr10:67,028,328...67,032,926
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|
G |
Cftr |
CF transmembrane conductance regulator |
susceptibility |
ISO |
DNA:deletion: :F508del(human) associated with pulmonary disease chronic obstructive; DNA:missense mutation:exon:p.R75Q(human) |
RGD |
PMID:10767489 PMID:15463907 |
RGD:4140484, RGD:4140475 |
NCBI chr 4:46,561,269...46,728,759
Ensembl chr 4:46,560,885...46,728,756
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|
G |
Ctla4 |
cytotoxic T-lymphocyte-associated protein 4 |
|
ISO |
DNA:SNPs: :multiple (human) |
RGD |
PMID:19386687 |
RGD:4891509 |
NCBI chr 9:62,318,874...62,325,978
Ensembl chr 9:62,319,312...62,324,963
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|
G |
Cyp1a1 |
cytochrome P450, family 1, subfamily a, polypeptide 1 |
susceptibility |
ISO |
DNA:polymorphism (human) |
RGD |
PMID:15928955 |
RGD:4142512 |
NCBI chr 8:58,096,021...58,102,130
Ensembl chr 8:58,096,077...58,102,125
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|
G |
Cyp2e1 |
cytochrome P450, family 2, subfamily e, polypeptide 1 |
|
ISO |
DNA:polymorphism (human) |
RGD |
PMID:14593914 |
RGD:4889126 |
NCBI chr 1:195,840,330...195,850,728
Ensembl chr 1:195,840,058...195,864,023
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|
G |
Edn1 |
endothelin 1 |
|
ISO |
Chronic Allergic Airway Inflammation; protein:increased secretion:bronchoalveolar lavage (mouse) |
RGD |
PMID:18631350 |
RGD:4145074 |
NCBI chr17:22,454,924...22,460,812
Ensembl chr17:22,454,420...22,460,885
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G |
Gc |
GC, vitamin D binding protein |
susceptibility |
ISO |
|
RGD |
PMID:12096683 |
RGD:5129516 |
NCBI chr14:18,632,146...18,667,563
Ensembl chr14:18,632,135...18,667,567
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|
G |
Gstm1 |
glutathione S-transferase mu 1 |
severity |
ISO |
DNA:deletion: : DNA:deletion, haplotype: : (human) |
RGD |
PMID:9187680 PMID:15125256 |
RGD:4142513, RGD:12798508 |
NCBI chr 2:195,649,845...195,655,402
Ensembl chr 2:195,649,845...195,655,411
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G |
Gstt1 |
glutathione S-transferase theta 1 |
susceptibility |
ISO |
DNA:deletion: : |
RGD |
PMID:15928955 |
RGD:4142512 |
NCBI chr20:12,856,613...12,873,586
Ensembl chr20:12,856,669...12,873,585
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G |
Icam1 |
intercellular adhesion molecule 1 |
|
IEP |
protein:increased expression:bronchial epithelium (rat) |
RGD |
PMID:19507274 |
RGD:2308951 |
NCBI chr 8:19,553,063...19,565,438
Ensembl chr 8:19,553,645...19,565,438
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|
G |
Il10 |
interleukin 10 |
|
IEP |
protein:decreased expression:lung |
RGD |
PMID:19507274 |
RGD:2308951 |
NCBI chr13:42,472,625...42,477,308
Ensembl chr13:42,472,839...42,477,313
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G |
Il13 |
interleukin 13 |
|
ISO |
protein:increased expression:Respiratory Mucosa |
RGD |
PMID:14582911 |
RGD:4759835 |
NCBI chr10:37,790,130...37,792,687
Ensembl chr10:37,790,130...37,792,737
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G |
Il15 |
interleukin 15 |
|
ISO |
mRNA, protein:increased expression:lung |
RGD |
PMID:11742275 |
RGD:4990461 |
NCBI chr19:25,640,025...25,706,818
Ensembl chr19:25,640,251...25,706,820
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G |
Mpo |
myeloperoxidase |
|
IEP |
protein:increased expression:lung |
RGD |
PMID:11798689 |
RGD:5130990 |
NCBI chr10:72,594,883...72,608,862
Ensembl chr10:72,594,661...72,604,819
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G |
Nos2 |
nitric oxide synthase 2 |
|
IDA |
|
RGD |
PMID:19938219 |
RGD:4891494 |
NCBI chr10:63,815,308...63,851,208
Ensembl chr10:63,815,308...63,851,210
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G |
Npy |
neuropeptide Y |
|
ISO |
CTD Direct Evidence: marker/mechanism |
CTD |
PMID:9731035 |
|
NCBI chr 4:78,881,294...78,888,495
Ensembl chr 4:78,881,264...78,888,495
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G |
Vegfa |
vascular endothelial growth factor A |
|
ISO |
CTD Direct Evidence: marker/mechanism |
CTD |
PMID:19263519 |
|
NCBI chr 9:14,955,300...14,970,641
Ensembl chr 9:14,955,300...14,970,641
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G |
Edn1 |
endothelin 1 |
|
ISO |
protein:increased expression:inferior turbinate, nasal gland, inflammatory cell (human) |
RGD |
PMID:8845175 |
RGD:8661738 |
NCBI chr17:22,454,924...22,460,812
Ensembl chr17:22,454,420...22,460,885
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G |
Cd8a |
CD8 subunit alpha |
ameliorates |
ISO |
protein:decreased expression:blood, T cell (human) |
RGD |
PMID:24639246 |
RGD:124715444 |
NCBI chr 4:103,365,804...103,370,041
Ensembl chr 4:103,365,804...103,370,040
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G |
Il17a |
interleukin 17A |
|
ISO |
protein:increased expression:uncinate process, nasal mucosa (human) |
RGD |
PMID:23613503 |
RGD:8696039 |
NCBI chr 9:23,144,402...23,147,889
Ensembl chr 9:23,144,402...23,147,889
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G |
Il1rn |
interleukin 1 receptor antagonist |
susceptibility |
ISO |
DNA:repeats:intron:IVS2+914_1000dup I/II alleles (human) |
RGD |
PMID:16549749 |
RGD:8549791 |
NCBI chr 3:7,111,567...7,127,451
Ensembl chr 3:7,111,550...7,127,445
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G |
Mbl2 |
mannose binding lectin 2 |
|
ISO |
protein:decreased activity:serum: |
RGD |
PMID:23144819 |
RGD:8693716 |
NCBI chr 1:228,016,439...228,024,736
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|
G |
Prg2 |
proteoglycan 2, pro eosinophil major basic protein |
disease_progression |
ISO |
associated with Nasal Polyps; |
RGD |
PMID:24450586 |
RGD:13506943 |
NCBI chr 3:70,062,535...70,066,102
Ensembl chr 3:70,062,535...70,066,101
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G |
Alox5 |
arachidonate 5-lipoxygenase |
|
ISO |
protein:increased expression:bronchus |
RGD |
PMID:11865407 |
RGD:4890421 |
NCBI chr 4:149,531,329...149,578,696
Ensembl chr 4:149,531,515...149,578,743
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G |
Alox5ap |
arachidonate 5-lipoxygenase activating protein |
|
ISO |
protein:increased expression:bronchus |
RGD |
PMID:11865407 |
RGD:4890421 |
NCBI chr12:5,748,941...5,772,986
Ensembl chr12:5,748,944...5,772,986
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G |
Cx3cl1 |
C-X3-C motif chemokine ligand 1 |
|
ISO |
|
RGD |
PMID:20696083 |
RGD:4140458 |
NCBI chr19:10,227,337...10,237,826
Ensembl chr19:10,227,340...10,236,833
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G |
Cxcl1 |
C-X-C motif chemokine ligand 1 |
|
ISO |
associated with Pulmonary Disease, Chronic Obstructive;protein:increased expression:respiratory epithelial cell |
RGD |
PMID:20395558 |
RGD:4145446 |
NCBI chr14:17,193,364...17,195,143
Ensembl chr14:17,193,365...17,195,215
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G |
Cxcl10 |
C-X-C motif chemokine ligand 10 |
|
ISO |
protein:increased expression:respiratory system fluid/secretion |
RGD |
PMID:15764644 |
RGD:5135489 |
NCBI chr14:15,704,772...15,706,969
Ensembl chr14:15,704,758...15,706,975
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G |
Cxcl3 |
C-X-C motif chemokine ligand 3 |
|
ISO |
associated with Pulmonary Disease, Chronic Obstructive;protein:increased expression:respiratory epithelial cell |
RGD |
PMID:20395558 |
RGD:4145446 |
NCBI chr14:17,287,727...17,289,451
Ensembl chr14:17,270,146...17,289,511
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G |
Cxcl6 |
C-X-C motif chemokine ligand 6 |
|
ISO |
associated with Asthma |
RGD |
PMID:12751040 |
RGD:5135264 |
NCBI chr14:17,310,790...17,312,250
Ensembl chr14:17,310,426...17,313,093
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G |
Cxcr2 |
C-X-C motif chemokine receptor 2 |
|
ISO |
|
RGD |
PMID:19864593 |
RGD:5131210 |
NCBI chr 9:75,729,493...75,735,868
Ensembl chr 9:75,729,115...75,739,425
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G |
Defb4 |
defensin beta 4 |
|
ISO |
mRNA, protein:increased expression:nasal cavity epithelium, nasal mucus |
RGD |
PMID:15034083 |
RGD:4892264 |
NCBI chr16:70,650,472...70,653,665
Ensembl chr16:70,650,472...70,653,665
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G |
Defb5 |
defensin beta 5 |
|
ISO |
mRNA, protein:increased expression:nasal cavity epithelium, nasal mucus |
RGD |
PMID:15034083 |
RGD:4892264 |
NCBI chr16:70,612,985...70,615,389
Ensembl chr16:70,613,146...70,615,467
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G |
Ifna2 |
interferon alpha 2 |
treatment |
ISO |
|
RGD |
PMID:6381610 |
RGD:40886344 |
NCBI chr 5:103,258,617...103,259,195
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G |
Il10 |
interleukin 10 |
|
ISO |
|
RGD |
PMID:20696083 |
RGD:4140458 |
NCBI chr13:42,472,625...42,477,308
Ensembl chr13:42,472,839...42,477,313
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G |
Il1a |
interleukin 1 alpha |
|
ISO |
protein:increased expression:nasal mucus |
RGD |
PMID:10358201 |
RGD:4143183 |
NCBI chr 3:116,526,601...116,537,055
Ensembl chr 3:116,526,604...116,536,822
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G |
Il1b |
interleukin 1 beta |
|
ISO |
protein:increased expression:nasal mucus |
RGD |
PMID:7734976 |
RGD:7401200 |
NCBI chr 3:116,577,005...116,583,386
Ensembl chr 3:116,577,010...116,583,415
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G |
Il1rn |
interleukin 1 receptor antagonist |
|
ISO |
protein:increased expression:nasal mucus |
RGD |
PMID:18279051 PMID:10358201 |
RGD:4143207, RGD:4143183 |
NCBI chr 3:7,111,567...7,127,451
Ensembl chr 3:7,111,550...7,127,445
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G |
Il33 |
interleukin 33 |
|
ISO |
protein:increased expression:nasal mucus |
RGD |
PMID:28471975 |
RGD:38596342 |
NCBI chr 1:227,701,964...227,736,374
Ensembl chr 1:227,721,435...227,736,373
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G |
Il4 |
interleukin 4 |
|
ISO |
associated with Asthma;mRNA, protein:increased expression:alveolar macrophage, respiratory system fluid/secretion |
RGD |
PMID:20644177 |
RGD:4140459 |
NCBI chr10:37,771,203...37,776,750
Ensembl chr10:37,771,203...37,776,750
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G |
Prdx5 |
peroxiredoxin 5 |
|
ISO |
associated with asthma;protein:increased expression:sputum (human) |
RGD |
PMID:18219526 |
RGD:41404684 |
NCBI chr 1:204,099,826...204,103,589
Ensembl chr 1:204,099,826...204,114,268
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G |
Tslp |
thymic stromal lymphopoietin |
|
ISO |
protein:increased expression:nasal mucus (human) |
RGD |
PMID:28471975 |
RGD:38596342 |
NCBI chr18:24,447,409...24,454,244
Ensembl chr18:24,449,844...24,453,548
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G |
Tnfrsf1a |
TNF receptor superfamily member 1A |
|
ISO |
protein:increased expression:lung, macrophage (human) |
RGD |
PMID:21144722 |
RGD:5131112 |
NCBI chr 4:158,150,815...158,163,592
Ensembl chr 4:158,150,820...158,163,591
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G |
Tnfrsf1b |
TNF receptor superfamily member 1B |
|
ISO |
protein:increased expression:lung, lymphocyte (human) |
RGD |
PMID:21144722 |
RGD:5131112 |
NCBI chr 5:157,070,642...157,104,216
Ensembl chr 5:157,070,642...157,104,206
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G |
Sftpc |
surfactant protein C |
|
ISS |
OMIM:263000 |
MouseDO |
|
|
NCBI chr15:45,596,565...45,599,615
Ensembl chr15:45,596,574...45,610,777
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|
|
G |
Mbl2 |
mannose binding lectin 2 |
susceptibility |
ISO |
DNA:SNP:exon:p.G54D(rs1800450)(human) |
RGD |
PMID:15249448 |
RGD:8693755 |
NCBI chr 1:228,016,439...228,024,736
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G |
Muc5ac |
mucin 5AC, oligomeric mucus/gel-forming |
|
ISO |
protein:decreased expression:bronchiole epithelium |
RGD |
PMID:15364771 |
RGD:7364741 |
NCBI chr 1:196,864,336...196,896,475
Ensembl chr 1:196,864,336...196,896,475
|
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G |
Muc5b |
mucin 5B, oligomeric mucus/gel-forming |
|
ISO |
DNA:insertion/deletion |
RGD |
PMID:15709052 |
RGD:7349353 |
NCBI chr 1:196,916,861...196,948,830
Ensembl chr 1:196,916,825...196,949,250
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G |
Mucl3 |
mucin like 3 |
|
ISO |
CTD Direct Evidence: marker/mechanism |
CTD |
PMID:22152429 |
|
NCBI chr20:3,100,652...3,108,569
Ensembl chr20:3,100,679...3,108,569
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G |
Tap2 |
transporter 2, ATP binding cassette subfamily B member |
susceptibility |
ISO |
DNA:polymorphisms:exon: |
RGD |
PMID:10323341 |
RGD:5147847 |
NCBI chr20:4,636,347...4,650,387
Ensembl chr20:4,636,357...4,650,407
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|
G |
Ccl7 |
C-C motif chemokine ligand 7 |
|
ISO |
protein:increased expression:ethmoid sinus |
RGD |
PMID:9800627 |
RGD:6483785 |
NCBI chr10:67,016,446...67,018,296
Ensembl chr10:67,016,446...67,018,303
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G |
C5 |
complement C5 |
|
ISO |
|
RGD |
PMID:2612053 |
RGD:5130160 |
NCBI chr 3:18,270,696...18,361,994
Ensembl chr 3:18,270,696...18,361,994
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G |
Ccl7 |
C-C motif chemokine ligand 7 |
|
ISO |
|
RGD |
PMID:20045013 |
RGD:5129686 |
NCBI chr10:67,016,446...67,018,296
Ensembl chr10:67,016,446...67,018,303
|
|
G |
Gata2 |
GATA binding protein 2 |
|
IEP |
associated with Pneumocystis Infections |
RGD |
PMID:16774119 |
RGD:9587813 |
NCBI chr 4:120,654,205...120,667,763
Ensembl chr 4:120,658,986...120,667,761
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|
G |
Il13 |
interleukin 13 |
|
IEP ISO |
protein:increased expression:lung |
RGD |
PMID:16544260 PMID:19752036 |
RGD:4145506, RGD:4145474 |
NCBI chr10:37,790,130...37,792,687
Ensembl chr10:37,790,130...37,792,737
|
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G |
Il33 |
interleukin 33 |
|
ISO |
protein:increased expression:lung |
RGD |
PMID:25746970 |
RGD:39938968 |
NCBI chr 1:227,701,964...227,736,374
Ensembl chr 1:227,721,435...227,736,373
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G |
Nos2 |
nitric oxide synthase 2 |
|
IEP |
protein:decreased expression:lung |
RGD |
PMID:10639453 |
RGD:4891455 |
NCBI chr10:63,815,308...63,851,208
Ensembl chr10:63,815,308...63,851,210
|
|
G |
Sftpa1 |
surfactant protein A1 |
susceptibility |
ISO |
|
RGD |
PMID:20413160 |
RGD:4143489 |
NCBI chr16:17,008,180...17,011,686
Ensembl chr16:17,008,180...17,011,685
|
|
G |
Sftpd |
surfactant protein D |
susceptibility |
ISO |
|
RGD |
PMID:20413160 PMID:20413160 |
RGD:4143489, RGD:4143489 |
NCBI chr16:17,046,491...17,058,968
Ensembl chr16:17,046,483...17,059,927
|
|
G |
Tnf |
tumor necrosis factor |
|
IEP |
protein:increased expression:lung |
RGD |
PMID:16544260 |
RGD:4145506 |
NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629
|
|
|
G |
Abo |
ABO, alpha 1-3-N-acetylgalactosaminyltransferase and alpha 1-3-galactosyltransferase |
susceptibility |
ISO |
DNA:polymorphism:cds:allele AB (human) |
RGD |
PMID:6189297 PMID:4375858 |
RGD:5128836, RGD:39938844 |
NCBI chr 3:10,162,087...10,182,835
Ensembl chr 3:10,162,096...10,191,423
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G |
Atf3 |
activating transcription factor 3 |
|
ISO |
CTD Direct Evidence: marker/mechanism |
CTD |
PMID:23326326 |
|
NCBI chr13:102,751,278...102,800,520
Ensembl chr13:102,751,321...102,764,631
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G |
C3 |
complement C3 |
|
ISO |
|
RGD |
PMID:21408070 |
RGD:5129492 |
NCBI chr 9:2,087,437...2,114,366
Ensembl chr 9:2,087,437...2,114,429
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G |
Casp1 |
caspase 1 |
|
ISO |
|
RGD |
PMID:19362023 |
RGD:5130181 |
NCBI chr 8:2,587,812...2,597,403
Ensembl chr 8:2,587,831...2,597,383
|
|
G |
Cat |
catalase |
|
ISO |
|
RGD |
PMID:16804020 PMID:20653246 PMID:19959187 |
RGD:5130864, RGD:5130201, RGD:5130744 |
NCBI chr 3:89,842,393...89,874,577
Ensembl chr 3:89,842,399...89,874,478
|
|
G |
Ccl11 |
C-C motif chemokine ligand 11 |
|
ISO |
associated with Asthma;protein:increased expression:respiratory system fluid/secretion |
RGD |
PMID:20656925 PMID:12707338 |
RGD:4145452, RGD:4145439 |
NCBI chr10:67,028,328...67,032,929
Ensembl chr10:67,028,328...67,032,926
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|
G |
Ccl2 |
C-C motif chemokine ligand 2 |
|
ISO |
mRNA:increased expression:lung CTD Direct Evidence: marker/mechanism |
CTD RGD |
PMID:23326326 PMID:20967263 |
RGD:4891425 |
NCBI chr10:67,005,424...67,007,222
Ensembl chr10:67,005,424...67,007,226
|
|
G |
Ccl28 |
C-C motif chemokine ligand 28 |
resistance |
ISO |
|
RGD |
PMID:19847203 |
RGD:4892196 |
NCBI chr 2:51,601,354...51,625,999
Ensembl chr 2:51,601,331...51,625,997
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G |
Ccl5 |
C-C motif chemokine ligand 5 |
susceptibility |
ISO |
protein:increased expression:lung (mouse) |
RGD |
PMID:20656925 PMID:16208318 |
RGD:4145452, RGD:4892131 |
NCBI chr10:68,322,826...68,327,380
Ensembl chr10:68,322,829...68,327,377
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G |
Ccr5 |
C-C motif chemokine receptor 5 |
severity |
ISO |
DNA:frameshift mutation:cds:p.S185_T195del rs333 (human) |
RGD |
PMID:19039768 PMID:18617426 PMID:20875295 |
RGD:4892119, RGD:4892122, RGD:4892063 |
NCBI chr 8:123,752,423...123,757,538
Ensembl chr 8:123,752,325...123,759,260
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G |
Cd14 |
CD14 molecule |
|
ISO |
|
RGD |
PMID:17825924 |
RGD:4144809 |
NCBI chr18:28,335,522...28,337,383
Ensembl chr18:28,335,340...28,337,261
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G |
Cd209c |
CD209c molecule |
susceptibility |
ISO |
|
RGD |
PMID:21191006 |
RGD:5131189 |
NCBI chr12:1,936,233...1,943,841
Ensembl chr12:1,936,396...1,942,040
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G |
Cd209d |
CD209d molecule |
susceptibility |
ISO |
|
RGD |
PMID:21191006 |
RGD:5131189 |
NCBI chr12:1,891,109...1,897,559
Ensembl chr12:1,891,113...1,901,171
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G |
Cd28 |
Cd28 molecule |
|
ISO |
|
RGD |
PMID:21389258 |
RGD:5131611 |
NCBI chr 9:62,166,324...62,194,674
Ensembl chr 9:62,166,192...62,194,685
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G |
Cd40 |
CD40 molecule |
|
ISO |
|
RGD |
PMID:19922665 |
RGD:5132270 |
NCBI chr 3:153,790,372...153,805,279
Ensembl chr 3:153,790,449...153,805,534
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G |
Cd80 |
Cd80 molecule |
|
ISO |
|
RGD |
PMID:19922665 PMID:10604996 |
RGD:5132270, RGD:5132623 |
NCBI chr11:62,254,543...62,293,414
Ensembl chr11:62,254,624...62,292,030
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G |
Cd86 |
CD86 molecule |
|
ISO |
protein:increased expression:mediastinal lymph node, B cell (mouse) |
RGD |
PMID:19933871 |
RGD:4892570 |
NCBI chr11:64,142,193...64,200,816
Ensembl chr11:64,163,828...64,200,818
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G |
Crp |
C-reactive protein |
|
ISO |
protein:increased expression:serum |
RGD |
PMID:21509252 |
RGD:5131277 |
NCBI chr13:85,135,384...85,175,178
Ensembl chr13:85,124,977...85,175,178
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G |
Csf2 |
colony stimulating factor 2 |
|
ISO |
|
RGD |
PMID:20427198 PMID:21474645 |
RGD:5131472, RGD:5131470 |
NCBI chr10:38,386,945...38,388,926
Ensembl chr10:38,386,945...38,389,199
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|
G |
Cxcl1 |
C-X-C motif chemokine ligand 1 |
|
ISO |
protein:increased expression:respiratory system fluid/secretion protein:increased expression:lung, serum |
RGD |
PMID:20656925 PMID:17348295 |
RGD:4145452, RGD:4145366 |
NCBI chr14:17,193,364...17,195,143
Ensembl chr14:17,193,365...17,195,215
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G |
Cxcl10 |
C-X-C motif chemokine ligand 10 |
|
ISO |
CTD Direct Evidence: marker/mechanism |
CTD |
PMID:23326326 |
|
NCBI chr14:15,704,772...15,706,969
Ensembl chr14:15,704,758...15,706,975
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|
G |
Cxcl2 |
C-X-C motif chemokine ligand 2 |
|
ISO |
mRNA:increased expression:lung |
RGD |
PMID:21251691 PMID:20967263 |
RGD:5135026, RGD:4891425 |
NCBI chr14:17,181,030...17,183,075
Ensembl chr14:17,181,062...17,183,075
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G |
Ddx60 |
DEXD/H-box helicase 60 |
|
ISO |
CTD Direct Evidence: marker/mechanism |
CTD |
PMID:23326326 |
|
NCBI chr16:28,077,000...28,197,903
Ensembl chr16:28,076,999...28,179,526
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G |
Egr1 |
early growth response 1 |
|
ISO |
mRNA:increased expression:frontal cortex (mouse) |
RGD |
PMID:21289196 |
RGD:5131660 |
NCBI chr18:26,462,967...26,466,766
Ensembl chr18:26,462,981...26,466,766
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G |
Eif2ak2 |
eukaryotic translation initiation factor 2-alpha kinase 2 |
|
ISO |
CTD Direct Evidence: marker/mechanism |
CTD |
PMID:23326326 |
|
NCBI chr 6:16,189,000...16,224,972
Ensembl chr 6:16,188,979...16,224,971
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G |
Foxp2 |
forkhead box P2 |
|
ISO |
|
RGD |
PMID:18248790 |
RGD:11536002 |
NCBI chr 4:43,133,827...43,712,442
Ensembl chr 4:43,133,912...43,711,683
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|
G |
Gbp1 |
guanylate binding protein 1 |
|
ISO |
CTD Direct Evidence: marker/mechanism |
CTD |
PMID:23326326 |
|
NCBI chr 2:231,398,136...231,432,773
Ensembl chr 2:231,398,163...231,432,131 Ensembl chr 2:231,398,163...231,432,131
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|
G |
Herc6 |
HECT and RLD domain containing E3 ubiquitin protein ligase family member 6 |
|
ISO |
CTD Direct Evidence: marker/mechanism |
CTD |
PMID:23326326 |
|
NCBI chr 4:87,524,470...87,566,895
Ensembl chr 4:87,524,493...87,581,744
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|
G |
Ifi27 |
interferon, alpha-inducible protein 27 |
|
ISO |
CTD Direct Evidence: marker/mechanism |
CTD |
PMID:23326326 |
|
NCBI chr 6:122,590,461...122,596,996
Ensembl chr 6:122,590,472...122,779,294
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G |
Ifi35 |
interferon-induced protein 35 |
|
ISO |
CTD Direct Evidence: marker/mechanism |
CTD |
PMID:23326326 |
|
NCBI chr10:86,381,023...86,389,279
Ensembl chr10:86,381,010...86,389,952
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|
G |
Ifi44 |
interferon-induced protein 44 |
|
ISO |
CTD Direct Evidence: marker/mechanism |
CTD |
PMID:23326326 |
|
NCBI chr 2:240,626,058...240,643,879
Ensembl chr 2:240,626,066...240,643,844
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G |
Ifi44l |
interferon-induced protein 44-like |
|
ISO |
CTD Direct Evidence: marker/mechanism |
CTD |
PMID:23326326 |
|
NCBI chr 2:240,668,742...240,706,425
Ensembl chr 2:240,668,713...240,706,359
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G |
Ifih1 |
interferon induced with helicase C domain 1 |
|
ISO |
CTD Direct Evidence: marker/mechanism |
CTD |
PMID:23326326 |
|
NCBI chr 3:47,228,980...47,275,403
Ensembl chr 3:47,227,364...47,275,456
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G |
Ifit2 |
interferon-induced protein with tetratricopeptide repeats 2 |
|
ISO |
CTD Direct Evidence: marker/mechanism |
CTD |
PMID:23326326 |
|
NCBI chr 1:232,102,570...232,108,638
Ensembl chr 1:232,102,570...232,108,635
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G |
Ifit3 |
interferon-induced protein with tetratricopeptide repeats 3 |
|
ISO |
CTD Direct Evidence: marker/mechanism |
CTD |
PMID:23326326 |
|
NCBI chr 1:232,114,166...232,119,311
Ensembl chr 1:232,114,166...232,119,307
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|
G |
Ifitm3 |
interferon induced transmembrane protein 3 |
susceptibility |
ISO |
CTD Direct Evidence: marker/mechanism ClinVar Annotator: match by term: Influenza, severe, susceptibility to |
CTD ClinVar OMIM |
PMID:20943977 PMID:22446628 PMID:23326326 |
|
NCBI chr 1:196,111,026...196,112,135
Ensembl chr 1:196,111,043...196,112,203
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G |
Il10 |
interleukin 10 |
susceptibility |
ISO |
|
RGD |
PMID:20200252 |
RGD:4140426 |
NCBI chr13:42,472,625...42,477,308
Ensembl chr13:42,472,839...42,477,313
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G |
Il12b |
interleukin 12B |
|
ISO |
|
RGD |
PMID:16389596 |
RGD:4145426 |
NCBI chr10:28,888,832...28,903,802
Ensembl chr10:28,893,008...28,902,903
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G |
Il13 |
interleukin 13 |
|
ISO |
protein:increased expression:serum |
RGD |
PMID:20003352 |
RGD:4888530 |
NCBI chr10:37,790,130...37,792,687
Ensembl chr10:37,790,130...37,792,737
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G |
Il15 |
interleukin 15 |
|
ISO |
mRNA, protein:increased expression:lung |
RGD |
PMID:20212069 PMID:19234203 PMID:21098221 |
RGD:4996471, RGD:4996472, RGD:4994196 |
NCBI chr19:25,640,025...25,706,818
Ensembl chr19:25,640,251...25,706,820
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G |
Il15ra |
interleukin 15 receptor subunit alpha |
|
ISO |
|
RGD |
PMID:21098221 |
RGD:4994196 |
NCBI chr17:66,802,300...66,831,973
Ensembl chr17:66,802,334...66,832,278
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G |
Il17a |
interleukin 17A |
|
ISO |
mRNA, protein:increased expression:lung |
RGD |
PMID:19783685 PMID:19265125 |
RGD:4889102, RGD:4889150 |
NCBI chr 9:23,144,402...23,147,889
Ensembl chr 9:23,144,402...23,147,889
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G |
Il17ra |
interleukin 17 receptor A |
|
ISO |
|
RGD |
PMID:19783685 |
RGD:4889102 |
NCBI chr 4:153,667,534...153,690,174
Ensembl chr 4:153,667,534...153,690,174
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G |
Il18 |
interleukin 18 |
|
ISO |
|
RGD |
PMID:15606801 |
RGD:4889964 |
NCBI chr 8:50,904,630...50,932,887
Ensembl chr 8:50,906,960...50,932,887
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|
G |
Il1a |
interleukin 1 alpha |
|
ISO |
protein:increased expression:lung |
RGD |
PMID:11535264 |
RGD:4142860 |
NCBI chr 3:116,526,601...116,537,055
Ensembl chr 3:116,526,604...116,536,822
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G |
Il1b |
interleukin 1 beta |
|
ISO |
|
RGD |
PMID:20438620 |
RGD:4142822 |
NCBI chr 3:116,577,005...116,583,386
Ensembl chr 3:116,577,010...116,583,415
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|
G |
Il1rn |
interleukin 1 receptor antagonist |
disease_progression |
ISO |
protein:increased expression:serum |
RGD |
PMID:9439800 PMID:20840779 |
RGD:4143228, RGD:4143203 |
NCBI chr 3:7,111,567...7,127,451
Ensembl chr 3:7,111,550...7,127,445
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G |
Il2 |
interleukin 2 |
|
ISO |
protein:increased expression:serum |
RGD |
PMID:21603856 |
RGD:5147905 |
NCBI chr 2:120,004,862...120,009,566
Ensembl chr 2:120,004,862...120,009,566
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G |
Il22 |
interleukin 22 |
|
ISO |
|
RGD |
PMID:21178015 PMID:20504940 |
RGD:5147404, RGD:5147405 |
NCBI chr 7:53,801,206...53,805,673
Ensembl chr 7:53,801,206...53,806,186
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G |
Il4 |
interleukin 4 |
|
ISO |
|
RGD |
PMID:21092162 |
RGD:5128546 |
NCBI chr10:37,771,203...37,776,750
Ensembl chr10:37,771,203...37,776,750
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G |
Il6 |
interleukin 6 |
|
ISO |
|
RGD |
PMID:20731583 |
RGD:4143268 |
NCBI chr 4:5,214,602...5,219,178
Ensembl chr 4:5,213,394...5,219,178
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G |
Irf7 |
interferon regulatory factor 7 |
|
ISO |
CTD Direct Evidence: marker/mechanism |
CTD |
PMID:23326326 |
|
NCBI chr 1:196,367,380...196,370,943
Ensembl chr 1:196,367,361...196,370,832
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G |
Isg15 |
ISG15 ubiquitin-like modifier |
|
ISO |
CTD Direct Evidence: marker/mechanism |
CTD |
PMID:23326326 |
|
NCBI chr 5:166,784,148...166,785,435
Ensembl chr 5:166,784,148...166,785,435
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|
G |
Lamp3 |
lysosomal-associated membrane protein 3 |
|
ISO |
CTD Direct Evidence: marker/mechanism |
CTD |
PMID:23326326 |
|
NCBI chr11:81,153,491...81,224,643
Ensembl chr11:81,193,649...81,221,784
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G |
Ly6e |
lymphocyte antigen 6 family member E |
|
ISO |
CTD Direct Evidence: marker/mechanism |
CTD |
PMID:23326326 |
|
NCBI chr 7:106,935,530...106,939,689
Ensembl chr 7:106,935,761...106,939,689
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G |
Lyst |
lysosomal trafficking regulator |
|
ISO |
CTD Direct Evidence: marker/mechanism |
CTD |
PMID:26597256 |
|
NCBI chr17:86,241,384...86,443,501
Ensembl chr17:86,241,384...86,443,480
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G |
Mmp9 |
matrix metallopeptidase 9 |
|
ISO |
protein:increased activity:lung, heart, brain |
RGD |
PMID:20299740 |
RGD:5130855 |
NCBI chr 3:153,684,158...153,692,118
Ensembl chr 3:153,683,858...153,692,120
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G |
Mx1 |
MX dynamin like GTPase 1 |
|
ISO |
CTD Direct Evidence: marker/mechanism |
CTD |
PMID:23326326 |
|
NCBI chr11:36,799,659...36,825,209
Ensembl chr11:36,799,660...36,823,507
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G |
Mx2 |
MX dynamin like GTPase 2 |
|
ISO |
CTD Direct Evidence: marker/mechanism |
CTD |
PMID:23326326 |
|
NCBI chr11:36,905,698...36,936,308
Ensembl chr11:36,906,111...36,930,342
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G |
Nos1 |
nitric oxide synthase 1 |
|
ISO |
protein:increased expression:hippocampus |
RGD |
PMID:9552178 |
RGD:5132870 |
NCBI chr12:38,615,111...38,795,492
Ensembl chr12:38,626,714...38,710,945
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G |
Nos2 |
nitric oxide synthase 2 |
|
ISO |
mRNA:increased expression:olfactory epithelium mRNA,protein:increased expression:brain |
RGD |
PMID:17674769 PMID:18080188 PMID:17030871 |
RGD:4891919, RGD:4891937, RGD:4891952 |
NCBI chr10:63,815,308...63,851,208
Ensembl chr10:63,815,308...63,851,210
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G |
Oas1a |
2'-5' oligoadenylate synthetase 1A |
|
ISO |
CTD Direct Evidence: marker/mechanism |
CTD |
PMID:23326326 |
|
NCBI chr12:35,669,798...35,680,505
Ensembl chr12:35,669,801...35,680,517
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G |
Oas2 |
2'-5' oligoadenylate synthetase 2 |
|
ISO |
CTD Direct Evidence: marker/mechanism |
CTD |
PMID:23326326 |
|
NCBI chr12:35,802,824...35,830,778
Ensembl chr12:35,806,759...35,829,371
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G |
Oas3 |
2'-5'-oligoadenylate synthetase 3 |
|
ISO |
CTD Direct Evidence: marker/mechanism |
CTD |
PMID:23326326 |
|
NCBI chr12:35,779,028...35,802,781
Ensembl chr12:35,779,022...35,802,781
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G |
Oasl |
2'-5'-oligoadenylate synthetase-like |
|
ISO |
CTD Direct Evidence: marker/mechanism |
CTD |
PMID:23326326 |
|
NCBI chr12:41,682,900...41,695,641
Ensembl chr12:41,682,900...41,695,641
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G |
Parp12 |
poly (ADP-ribose) polymerase family, member 12 |
|
ISO |
CTD Direct Evidence: marker/mechanism |
CTD |
PMID:23326326 |
|
NCBI chr 4:67,826,548...67,885,356
Ensembl chr 4:67,839,237...67,883,685
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G |
Plscr1 |
phospholipid scramblase 1 |
|
ISO |
CTD Direct Evidence: marker/mechanism |
CTD |
PMID:23326326 |
|
NCBI chr 8:92,784,279...92,804,698
Ensembl chr 8:92,784,356...92,804,692
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G |
Prf1 |
perforin 1 |
|
ISO |
CTD Direct Evidence: marker/mechanism |
CTD |
PMID:26597256 |
|
NCBI chr20:29,246,202...29,251,712
Ensembl chr20:29,246,202...29,251,701
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G |
Ptgs2 |
prostaglandin-endoperoxide synthase 2 |
|
ISO |
|
RGD |
PMID:16272346 |
RGD:5143925 |
NCBI chr13:62,163,936...62,172,193
Ensembl chr13:62,163,932...62,172,188
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G |
Rig1 |
RNA sensor RIG-1 |
|
ISO |
CTD Direct Evidence: marker/mechanism |
CTD |
PMID:23326326 |
|
NCBI chr 5:55,321,351...55,369,947
Ensembl chr 5:55,321,235...55,370,819
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G |
Rsad2 |
radical S-adenosyl methionine domain containing 2 |
|
ISO |
CTD Direct Evidence: marker/mechanism |
CTD |
PMID:23326326 |
|
NCBI chr 6:43,046,514...43,059,737
Ensembl chr 6:43,047,658...43,059,699
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G |
RT1-Db1 |
RT1 class II, locus Db1 |
|
ISO |
|
RGD |
PMID:19386707 |
RGD:4144816 |
NCBI chr20:4,548,664...4,558,237
Ensembl chr20:4,548,666...4,558,258
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G |
RT1-M3-1 |
RT1 class Ib, locus M3, gene 1 |
|
ISO |
|
RGD |
PMID:21087648 |
RGD:5144131 |
NCBI chr20:1,323,976...1,328,126
Ensembl chr20:1,287,521...1,328,117
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G |
Rtp4 |
receptor (chemosensory) transporter protein 4 |
|
ISO |
CTD Direct Evidence: marker/mechanism |
CTD |
PMID:23326326 |
|
NCBI chr11:77,237,341...77,249,194
Ensembl chr11:77,238,216...77,335,437
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G |
Samd9 |
sterile alpha motif domain containing 9 |
|
ISO |
CTD Direct Evidence: marker/mechanism |
CTD |
PMID:23326326 |
|
NCBI chr 4:31,164,639...31,184,278
Ensembl chr 4:31,164,510...31,184,322
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|
G |
Serping1 |
serpin family G member 1 |
|
ISO |
CTD Direct Evidence: marker/mechanism |
CTD |
PMID:23326326 |
|
NCBI chr 3:69,842,726...69,852,583
Ensembl chr 3:69,842,739...69,852,034
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|
G |
Sftpd |
surfactant protein D |
|
IMP |
|
RGD |
PMID:16787926 |
RGD:4143518 |
NCBI chr16:17,046,491...17,058,968
Ensembl chr16:17,046,483...17,059,927
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G |
Siglec1 |
sialic acid binding Ig like lectin 1 |
|
ISO |
CTD Direct Evidence: marker/mechanism |
CTD |
PMID:23326326 |
|
NCBI chr 3:118,287,988...118,307,125
Ensembl chr 3:118,287,988...118,306,850
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|
G |
Slc22a8 |
solute carrier family 22 member 8 |
|
ISO |
CTD Direct Evidence: marker/mechanism |
CTD |
PMID:23129053 |
|
NCBI chr 1:205,496,331...205,516,378
Ensembl chr 1:205,498,084...205,517,450
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|
G |
Stat1 |
signal transducer and activator of transcription 1 |
|
ISO |
CTD Direct Evidence: marker/mechanism |
CTD |
PMID:23326326 |
|
NCBI chr 9:49,419,561...49,459,969
Ensembl chr 9:49,419,340...49,588,540
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|
G |
Tdrd7 |
tudor domain containing 7 |
|
ISO |
CTD Direct Evidence: marker/mechanism |
CTD |
PMID:23326326 |
|
NCBI chr 5:60,238,742...60,312,548
Ensembl chr 5:60,238,678...60,312,544
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G |
Tlr2 |
toll-like receptor 2 |
|
ISO |
protein:increased expression:monocyte |
RGD |
PMID:18657324 |
RGD:4145339 |
NCBI chr 2:169,200,620...169,206,819
Ensembl chr 2:169,197,419...169,206,630
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|
G |
Tlr3 |
toll-like receptor 3 |
|
ISO |
mRNA:increased expression:lung (mouse) |
RGD |
PMID:16789835 PMID:18654661 |
RGD:5129219, RGD:5129136 |
NCBI chr16:46,821,980...46,837,900
Ensembl chr16:46,822,039...46,836,545
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|
G |
Tmprss11d |
transmembrane serine protease 11D |
|
ISO |
CTD Direct Evidence: marker/mechanism |
CTD |
PMID:20237084 PMID:23072892 |
|
NCBI chr14:21,707,336...21,769,398
Ensembl chr14:21,707,336...21,769,396
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|
G |
Tmprss4 |
transmembrane serine protease 4 |
|
ISO |
CTD Direct Evidence: marker/mechanism |
CTD |
PMID:26889029 |
|
NCBI chr 8:45,475,819...45,508,409
Ensembl chr 8:45,476,053...45,508,409
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G |
Tnf |
tumor necrosis factor |
|
ISO |
protein:increased expression:serum |
RGD |
PMID:21062445 |
RGD:5128683 |
NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629
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G |
Tnfaip6 |
TNF alpha induced protein 6 |
|
ISO |
CTD Direct Evidence: marker/mechanism |
CTD |
PMID:23326326 |
|
NCBI chr 3:36,502,250...36,521,652
Ensembl chr 3:36,502,188...36,521,649
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G |
Tnfrsf1a |
TNF receptor superfamily member 1A |
|
ISO |
protein:increased expression:serum (human) |
RGD |
PMID:17182684 PMID:19497758 |
RGD:5131157, RGD:5131432 |
NCBI chr 4:158,150,815...158,163,592
Ensembl chr 4:158,150,820...158,163,591
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G |
Tnfsf10 |
TNF superfamily member 10 |
|
ISO |
CTD Direct Evidence: marker/mechanism |
CTD |
PMID:23326326 |
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NCBI chr 2:110,199,835...110,227,239
Ensembl chr 2:110,207,916...110,225,135
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G |
Tor1b |
torsin family 1, member B |
|
ISO |
CTD Direct Evidence: marker/mechanism |
CTD |
PMID:23326326 |
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NCBI chr 3:14,243,181...14,249,279
Ensembl chr 3:14,243,243...14,249,272
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G |
Trex1 |
three prime repair exonuclease 1 |
|
ISO |
CTD Direct Evidence: marker/mechanism |
CTD |
PMID:23326326 |
|
NCBI chr 8:109,706,613...109,707,913
Ensembl chr 8:109,706,613...109,708,796
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G |
Ube2l6 |
ubiquitin-conjugating enzyme E2L 6 |
|
ISO |
CTD Direct Evidence: marker/mechanism |
CTD |
PMID:23326326 |
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NCBI chr 3:69,873,025...69,888,042
Ensembl chr 3:69,873,424...69,888,048
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G |
Ugcg |
UDP-glucose ceramide glucosyltransferase |
|
ISO |
CTD Direct Evidence: marker/mechanism |
CTD |
PMID:33639165 |
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NCBI chr 5:74,032,978...74,065,701
Ensembl chr 5:74,032,978...74,065,393
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G |
Xaf1 |
XIAP associated factor 1 |
|
ISO |
CTD Direct Evidence: marker/mechanism |
CTD |
PMID:23326326 |
|
NCBI chr10:56,917,378...56,929,791
Ensembl chr10:56,917,121...56,929,770
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G |
Xist |
X inactive specific transcript |
|
ISO |
CTD Direct Evidence: marker/mechanism |
CTD |
PMID:23326326 |
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NCBI chr X:68,474,987...68,492,500
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Zcchc2 |
zinc finger CCHC-type containing 2 |
|
ISO |
CTD Direct Evidence: marker/mechanism |
CTD |
PMID:23326326 |
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NCBI chr13:22,118,677...22,193,626
Ensembl chr13:22,119,568...22,166,373
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Cxcl6 |
C-X-C motif chemokine ligand 6 |
|
ISO |
associated with Scleroderma, Diffuse protein:increased expression:serum |
RGD |
PMID:18432520 PMID:16085216 |
RGD:5135258, RGD:5135260 |
NCBI chr14:17,310,790...17,312,250
Ensembl chr14:17,310,426...17,313,093
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Icam1 |
intercellular adhesion molecule 1 |
|
ISO |
protein:increased expression:lung, alveolar macrophage (human) |
RGD |
PMID:19218648 |
RGD:4145518 |
NCBI chr 8:19,553,063...19,565,438
Ensembl chr 8:19,553,645...19,565,438
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G |
Il6 |
interleukin 6 |
|
IEP |
protein:increased expression:bronchoalveolar lavage (rat) |
RGD |
PMID:10988147 |
RGD:11062092 |
NCBI chr 4:5,214,602...5,219,178
Ensembl chr 4:5,213,394...5,219,178
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G |
Keap1 |
Kelch-like ECH-associated protein 1 |
|
ISO |
protein:increased expression:hyperplastic lung epithelium, alveolus (human) |
RGD |
PMID:20718723 |
RGD:6893300 |
NCBI chr 8:19,768,375...19,777,862
Ensembl chr 8:19,768,375...19,777,862
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G |
Mtor |
mechanistic target of rapamycin kinase |
|
ISO |
|
RGD |
PMID:21444868 |
RGD:7245946 |
NCBI chr 5:158,884,856...158,994,311
Ensembl chr 5:158,884,804...158,994,311
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G |
Scgb1a1 |
secretoglobin family 1A member 1 |
|
ISO |
protein:increased expression:serum |
RGD |
PMID:15467329 |
RGD:5144148 |
NCBI chr 1:205,977,060...205,980,610
Ensembl chr 1:205,977,060...205,980,610
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Atm |
ATM serine/threonine kinase |
exacerbates |
ISO |
|
RGD |
PMID:31509427 |
RGD:126779564 |
NCBI chr 8:53,828,741...53,932,773
Ensembl chr 8:53,831,093...53,932,437
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Btk |
Bruton tyrosine kinase |
ameliorates |
ISO |
Associated with Acute Lung Injury |
RGD |
PMID:29516781 |
RGD:124713566 |
NCBI chr X:97,722,796...97,762,315
Ensembl chr X:97,722,802...97,761,853
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Duox1 |
dual oxidase 1 |
|
ISO |
protein:decreased expression:blood plasma (human) |
RGD |
PMID:24888898 |
RGD:40903071 |
NCBI chr 3:109,260,526...109,295,588
Ensembl chr 3:109,262,397...109,295,563
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G |
Duox2 |
dual oxidase 2 |
severity |
ISO |
|
RGD |
PMID:28936773 PMID:25751630 PMID:29556357 |
RGD:40924644, RGD:40925925, RGD:40925921 |
NCBI chr 3:109,223,809...109,247,023
Ensembl chr 3:109,226,924...109,245,902
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Ifih1 |
interferon induced with helicase C domain 1 |
|
ISO |
mRNA:increased expression:nasal cavity mucosa (mouse) |
RGD |
PMID:25751630 |
RGD:40925925 |
NCBI chr 3:47,228,980...47,275,403
Ensembl chr 3:47,227,364...47,275,456
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Il21 |
interleukin 21 |
|
ISO |
|
RGD |
PMID:25251568 |
RGD:127285548 |
NCBI chr 2:120,117,105...120,127,012
Ensembl chr 2:120,119,444...120,126,996
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G |
Il27 |
interleukin 27 |
|
ISO |
protein:increased expression:blood serum (human) |
RGD |
PMID:22343630 |
RGD:126790513 |
NCBI chr 1:181,173,108...181,178,720
Ensembl chr 1:181,173,372...181,178,582
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G |
Map3k8 |
mitogen-activated protein kinase kinase kinase 8 |
exacerbates |
ISO |
|
RGD |
PMID:26241898 |
RGD:11055126 |
NCBI chr17:53,382,908...53,403,216
Ensembl chr17:53,383,131...53,403,216
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G |
Mapk8 |
mitogen-activated protein kinase 8 |
ameliorates |
ISO |
|
RGD |
PMID:22514650 |
RGD:150340681 |
NCBI chr16:8,638,897...8,721,960
Ensembl chr16:8,638,924...8,721,981
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G |
Marco |
macrophage receptor with collagenous structure |
ameliorates |
ISO |
|
RGD |
PMID:21562316 |
RGD:41412197 |
NCBI chr13:31,616,278...31,648,521
Ensembl chr13:31,616,278...31,648,521
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G |
Mavs |
mitochondrial antiviral signaling protein |
disease_progression |
ISO |
|
RGD |
PMID:27438481 |
RGD:40903047 |
NCBI chr 3:118,451,650...118,466,094
Ensembl chr 3:118,451,743...118,466,094
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G |
Mir146a |
microRNA 146a |
exacerbates ameliorates |
ISO |
|
RGD |
PMID:31638222 PMID:30611999 |
RGD:126925152, RGD:126925153 |
NCBI chr10:27,848,516...27,848,610
Ensembl chr10:27,848,516...27,848,610
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G |
Mx1 |
MX dynamin like GTPase 1 |
ameliorates |
ISO |
fused with PTD 9-arginine sequence human gene in a mouse model |
RGD |
PMID:30696001 PMID:31653718 PMID:1371172 PMID:30945621 |
RGD:126777671, RGD:126777680, RGD:126777676, RGD:126777673 |
NCBI chr11:36,799,659...36,825,209
Ensembl chr11:36,799,660...36,823,507
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Plac8 |
placenta associated 8 |
|
ISO |
|
RGD |
PMID:32639988 |
RGD:40925929 |
NCBI chr14:9,052,601...9,074,264
Ensembl chr14:9,063,048...9,074,264
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G |
Ppia |
peptidylprolyl isomerase A |
ameliorates |
ISO |
human gene in a mouse model |
RGD |
PMID:27354005 |
RGD:150429624 |
NCBI chr14:81,279,292...81,282,960
Ensembl chr14:81,275,091...81,299,601
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G |
Rig1 |
RNA sensor RIG-1 |
|
ISO |
mRNA:increased expression:nasal cavity mucosa (mouse) |
RGD |
PMID:25751630 |
RGD:40925925 |
NCBI chr 5:55,321,351...55,369,947
Ensembl chr 5:55,321,235...55,370,819
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G |
Ripk3 |
receptor-interacting serine-threonine kinase 3 |
exacerbates susceptibility |
ISO |
|
RGD |
PMID:27321907 PMID:32200799 PMID:28410401 |
RGD:127229911, RGD:127229922, RGD:127229918 |
NCBI chr15:29,283,153...29,292,107
Ensembl chr15:29,283,145...29,292,121
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Stat2 |
signal transducer and activator of transcription 2 |
exacerbates |
ISO |
|
RGD |
PMID:30337919 |
RGD:41789626 |
NCBI chr 7:702,565...718,349
Ensembl chr 7:702,495...718,967
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G |
Ager |
advanced glycosylation end product-specific receptor |
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ISO |
|
RGD |
PMID:21423669 |
RGD:5508765 |
NCBI chr20:4,148,150...4,151,361
Ensembl chr20:4,147,890...4,151,078
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G |
Ccl2 |
C-C motif chemokine ligand 2 |
severity |
ISO |
|
RGD |
PMID:11160230 |
RGD:11528533 |
NCBI chr10:67,005,424...67,007,222
Ensembl chr10:67,005,424...67,007,226
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G |
Ccl20 |
C-C motif chemokine ligand 20 |
|
ISO |
protein:increased expression:lung |
RGD |
PMID:20926800 |
RGD:7483599 |
NCBI chr 9:84,389,031...84,391,629
Ensembl chr 9:84,388,904...84,391,629
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G |
Ccr6 |
C-C motif chemokine receptor 6 |
disease_progression |
ISO |
|
RGD |
PMID:17379855 |
RGD:7483617 |
NCBI chr 1:52,474,477...52,508,301
Ensembl chr 1:52,474,168...52,498,603
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G |
Cxcr3 |
C-X-C motif chemokine receptor 3 |
|
ISO |
|
RGD |
PMID:17298426 |
RGD:5135501 |
NCBI chr X:66,844,318...66,846,969
Ensembl chr X:66,844,318...66,846,969
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G |
Cybb |
cytochrome b-245 beta chain |
|
ISO |
|
RGD |
PMID:24054721 |
RGD:10450528 |
NCBI chr X:13,358,101...13,392,570
Ensembl chr X:13,359,430...13,392,586
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G |
Cyp2c6 |
cytochrome P450, family 2, subfamily C, polypeptide 6 |
treatment |
ISO |
DNA:polymorphisms:cds: |
RGD |
PMID:26861072 |
RGD:124713410 |
NCBI chr 1:237,938,521...237,976,238
Ensembl chr 1:237,693,094...238,057,596
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G |
Elane |
elastase, neutrophil expressed |
|
ISO |
|
RGD |
PMID:24054721 |
RGD:10450528 |
NCBI chr 7:9,817,251...9,819,174
Ensembl chr 7:9,817,252...9,819,100
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G |
Il17a |
interleukin 17A |
severity |
ISO |
|
RGD |
PMID:21807912 |
RGD:8698654 |
NCBI chr 9:23,144,402...23,147,889
Ensembl chr 9:23,144,402...23,147,889
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G |
Mbl2 |
mannose binding lectin 2 |
|
ISO |
DNA:SNP:exon:rs5030737(human) |
RGD |
PMID:17311505 |
RGD:8693758 |
NCBI chr 1:228,016,439...228,024,736
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G |
Ptx3 |
pentraxin 3 |
severity |
ISO |
DNA:SNPs, missense mutation:intron, cds:rs2305619, rs1840680, rs3816527 protein:increased expression:bronchoalveolar lavage fluid (human) |
RGD |
PMID:30275011 PMID:28487045 |
RGD:38501097, RGD:38508892 |
NCBI chr 2:150,487,513...150,493,323
Ensembl chr 2:150,487,513...150,493,323
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S100b |
S100 calcium binding protein B |
|
ISO |
|
RGD |
PMID:21423669 |
RGD:5508765 |
NCBI chr20:12,372,866...12,381,619
Ensembl chr20:12,372,881...12,394,743
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G |
Tlr2 |
toll-like receptor 2 |
|
ISO |
|
RGD |
PMID:16113258 |
RGD:8553022 |
NCBI chr 2:169,200,620...169,206,819
Ensembl chr 2:169,197,419...169,206,630
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G |
Tlr4 |
toll-like receptor 4 |
susceptibility |
ISO |
DNA:polymorphism:exon:p.D299G(human) |
RGD |
PMID:18275280 |
RGD:5130863 |
NCBI chr 5:80,145,867...80,159,501
Ensembl chr 5:80,145,826...80,159,628
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G |
Ccl2 |
C-C motif chemokine ligand 2 |
treatment |
IDA |
|
RGD |
PMID:12917249 |
RGD:11528529 |
NCBI chr10:67,005,424...67,007,222
Ensembl chr10:67,005,424...67,007,226
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G |
Cd209d |
CD209d molecule |
susceptibility |
ISO |
DNA:SNPs:3'utr,intron:multiple |
RGD |
PMID:22384201 |
RGD:39938996 |
NCBI chr12:1,891,109...1,897,559
Ensembl chr12:1,891,113...1,901,171
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G |
Fgf2 |
fibroblast growth factor 2 |
treatment |
ISO |
|
RGD |
PMID:23303813 |
RGD:8655596 |
NCBI chr 2:120,236,328...120,290,673
Ensembl chr 2:120,236,328...120,291,221
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G |
Il1a |
interleukin 1 alpha |
|
ISO |
DNA:polymorphism, haplotype:promoter:-889C>T (human) |
RGD |
PMID:18484169 |
RGD:4142867 |
NCBI chr 3:116,526,601...116,537,055
Ensembl chr 3:116,526,604...116,536,822
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G |
Il1b |
interleukin 1 beta |
|
ISO |
DNA:polymorphism, haplotype: :-511C>T (human) |
RGD |
PMID:18484169 |
RGD:4142867 |
NCBI chr 3:116,577,005...116,583,386
Ensembl chr 3:116,577,010...116,583,415
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G |
Itih4 |
inter-alpha-trypsin inhibitor heavy chain 4 |
|
IEP |
protein:increased expression:respiratory system fluid/secretion, serum |
RGD |
PMID:24360996 |
RGD:40903005 |
NCBI chr16:6,080,539...6,095,710
Ensembl chr16:6,080,539...6,095,708
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G |
Mbl2 |
mannose binding lectin 2 |
treatment |
ISO |
|
RGD |
PMID:17335555 |
RGD:8693746 |
NCBI chr 1:228,016,439...228,024,736
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G |
Ptx3 |
pentraxin 3 |
susceptibility no_association |
ISO |
DNA:SNP:intron:rs1840680 (human) protein:increased expression:bronchoalveolar lavage fluid, plasma (human) protein:increased expression:plasma DNA:SNP, missense mutation:intron, cds:rs2305619, rs3816527 |
RGD |
PMID:29020397 PMID:29964232 PMID:29020397 PMID:29020397 |
RGD:38501098, RGD:38508894, RGD:38501098, RGD:38501098 |
NCBI chr 2:150,487,513...150,493,323
Ensembl chr 2:150,487,513...150,493,323
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Vegfa |
vascular endothelial growth factor A |
treatment |
ISO |
|
RGD |
PMID:23303813 |
RGD:8655596 |
NCBI chr 9:14,955,300...14,970,641
Ensembl chr 9:14,955,300...14,970,641
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G |
Il23a |
interleukin 23 subunit alpha |
severity |
ISO |
|
RGD |
PMID:16157683 |
RGD:39457940 |
NCBI chr 7:721,809...723,923
Ensembl chr 7:721,809...723,923
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G |
Irak3 |
interleukin-1 receptor-associated kinase 3 |
severity |
ISO |
mRNA:increased expression:lung (mouse) |
RGD |
PMID:22729155 PMID:20864681 |
RGD:35316077, RGD:36049798 |
NCBI chr 7:55,653,949...55,714,371
Ensembl chr 7:55,653,962...55,713,121
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G |
Lcn2 |
lipocalin 2 |
exacerbates ameliorates |
ISO |
protein:increased expression:lung protein:increased expression:serum |
RGD |
PMID:29633303 PMID:19342674 PMID:19342674 PMID:19342674 PMID:25234944 PMID:25234944 More...
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RGD:126725082, RGD:126725085, RGD:126725085, RGD:126725085, RGD:126725084, RGD:126725084 |
NCBI chr 3:15,680,688...15,684,033
Ensembl chr 3:15,680,687...15,684,095
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G |
Plac8 |
placenta associated 8 |
severity |
ISO |
|
RGD |
PMID:17404296 |
RGD:40924563 |
NCBI chr14:9,052,601...9,074,264
Ensembl chr14:9,063,048...9,074,264
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G |
Trem1 |
triggering receptor expressed on myeloid cells 1 |
disease_progression |
ISO |
|
RGD |
PMID:24396044 |
RGD:126925976 |
NCBI chr 9:12,763,819...12,779,285
Ensembl chr 9:12,763,819...12,779,203
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Ada |
adenosine deaminase |
|
ISO |
protein:increased expression:serum |
RGD |
PMID:9255891 |
RGD:5128857 |
NCBI chr 3:152,398,745...152,422,854
Ensembl chr 3:152,398,747...152,447,088
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G |
Cx3cl1 |
C-X3-C motif chemokine ligand 1 |
|
ISO |
|
RGD |
PMID:16113250 |
RGD:4891897 |
NCBI chr19:10,227,337...10,237,826
Ensembl chr19:10,227,340...10,236,833
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G |
Cxcl1 |
C-X-C motif chemokine ligand 1 |
|
ISO |
mRNA, protein:increased expression:lung |
RGD |
PMID:11254553 |
RGD:5135252 |
NCBI chr14:17,193,364...17,195,143
Ensembl chr14:17,193,365...17,195,215
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G |
Cxcl2 |
C-X-C motif chemokine ligand 2 |
|
ISO |
mRNA, protein:increased expression:lung |
RGD |
PMID:11254553 |
RGD:5135252 |
NCBI chr14:17,181,030...17,183,075
Ensembl chr14:17,181,062...17,183,075
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G |
Cxcl6 |
C-X-C motif chemokine ligand 6 |
|
ISO |
mRNA, protein:increased expression:lung |
RGD |
PMID:11254553 |
RGD:5135252 |
NCBI chr14:17,310,790...17,312,250
Ensembl chr14:17,310,426...17,313,093
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G |
Cxcr2 |
C-X-C motif chemokine receptor 2 |
|
ISO |
|
RGD |
PMID:11254553 |
RGD:5135252 |
NCBI chr 9:75,729,493...75,735,868
Ensembl chr 9:75,729,115...75,739,425
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G |
Ifng |
interferon gamma |
|
ISO |
CTD Direct Evidence: therapeutic |
CTD |
PMID:11349020 |
|
NCBI chr 7:53,903,339...53,907,375
Ensembl chr 7:53,903,337...53,907,375
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G |
Il18 |
interleukin 18 |
|
ISO |
|
RGD |
PMID:11083766 |
RGD:4889865 |
NCBI chr 8:50,904,630...50,932,887
Ensembl chr 8:50,906,960...50,932,887
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G |
Mbl2 |
mannose binding lectin 2 |
susceptibility |
ISO |
|
RGD |
PMID:19073229 |
RGD:12910934 |
NCBI chr 1:228,016,439...228,024,736
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G |
Nod1 |
nucleotide-binding oligomerization domain containing 1 |
|
ISO |
|
RGD |
PMID:20685341 |
RGD:5131443 |
NCBI chr 4:84,060,871...84,111,668
Ensembl chr 4:84,060,880...84,111,404
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G |
Nod2 |
nucleotide-binding oligomerization domain containing 2 |
|
ISO |
|
RGD |
PMID:20685341 |
RGD:5131443 |
NCBI chr19:18,382,369...18,422,817
Ensembl chr19:18,382,439...18,417,177
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|
G |
Tlr5 |
toll-like receptor 5 |
|
ISO |
DNA:nonsense mutation:cds:p.R392X (human) ClinVar Annotator: match by term: Legionnaire disease, susceptibility to CTD Direct Evidence: marker/mechanism |
OMIM ClinVar CTD RGD |
PMID:14623910 PMID:16027372 PMID:23447684 PMID:14623910 PMID:17982089 |
RGD:5129477, RGD:5129510 |
NCBI chr13:94,634,778...94,658,992
Ensembl chr13:94,634,801...94,657,738
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G |
Tlr9 |
toll-like receptor 9 |
|
ISO |
|
RGD |
PMID:18426877 |
RGD:5130707 |
NCBI chr 8:106,864,680...106,868,796
Ensembl chr 8:106,864,680...106,868,796
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G |
Tnfrsf1a |
TNF receptor superfamily member 1A |
|
ISO |
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RGD |
PMID:18838275 |
RGD:5131445 |
NCBI chr 4:158,150,815...158,163,592
Ensembl chr 4:158,150,820...158,163,591
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G |
Tnfrsf1b |
TNF receptor superfamily member 1B |
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ISO |
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RGD |
PMID:18838275 |
RGD:5131445 |
NCBI chr 5:157,070,642...157,104,216
Ensembl chr 5:157,070,642...157,104,206
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Ada |
adenosine deaminase |
|
ISO |
protein:increased expression:serum |
RGD |
PMID:9255891 |
RGD:5128857 |
NCBI chr 3:152,398,745...152,422,854
Ensembl chr 3:152,398,747...152,447,088
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G |
Atp1b2 |
ATPase Na+/K+ transporting subunit beta 2 |
severity |
ISO |
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RGD |
PMID:28302172 |
RGD:32716376 |
NCBI chr10:54,318,698...54,324,933
Ensembl chr10:54,318,701...54,324,933
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G |
Ccl4 |
C-C motif chemokine ligand 4 |
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ISO |
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RGD |
PMID:16988274 |
RGD:4892091 |
NCBI chr10:68,466,394...68,468,229
Ensembl chr10:68,452,052...68,468,231
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G |
Ccl5 |
C-C motif chemokine ligand 5 |
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ISO |
protein:increased secretion:lung, secretion (mouse) |
RGD |
PMID:18717637 |
RGD:4891914 |
NCBI chr10:68,322,826...68,327,380
Ensembl chr10:68,322,829...68,327,377
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G |
Ccr5 |
C-C motif chemokine receptor 5 |
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ISO |
protein:increased expression:lung, T-helper cell (mouse) |
RGD |
PMID:16988274 |
RGD:4892091 |
NCBI chr 8:123,752,423...123,757,538
Ensembl chr 8:123,752,325...123,759,260
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G |
Clec5a |
C-type lectin domain containing 5A |
severity |
ISO |
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RGD |
PMID:28302172 |
RGD:32716376 |
NCBI chr 4:69,407,125...69,416,872
Ensembl chr 4:69,407,835...69,416,859
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G |
Col3a1 |
collagen type III alpha 1 chain |
severity |
ISO |
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RGD |
PMID:28302172 |
RGD:32716376 |
NCBI chr 9:47,374,611...47,410,547
Ensembl chr 9:47,374,593...47,410,547
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G |
Col6a1 |
collagen type VI alpha 1 chain |
severity |
ISO |
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RGD |
PMID:28302172 |
RGD:32716376 |
NCBI chr20:11,906,105...11,924,599
Ensembl chr20:11,905,957...11,924,597
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G |
Col6a2 |
collagen type VI alpha 2 chain |
severity |
ISO |
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RGD |
PMID:28302172 |
RGD:32716376 |
NCBI chr20:12,021,676...12,049,425
Ensembl chr20:12,021,767...12,057,564
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G |
Crp |
C-reactive protein |
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ISO |
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RGD |
PMID:21426633 |
RGD:5131292 |
NCBI chr13:85,135,384...85,175,178
Ensembl chr13:85,124,977...85,175,178
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G |
Dnase1l3 |
deoxyribonuclease 1L3 |
severity |
ISO |
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RGD |
PMID:28302172 |
RGD:32716376 |
NCBI chr15:16,922,335...16,948,322
Ensembl chr15:16,922,335...16,948,317
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G |
Fcer2 |
Fc epsilon receptor II |
severity |
ISO |
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RGD |
PMID:28302172 |
RGD:32716376 |
NCBI chr12:1,742,809...1,754,476
Ensembl chr12:1,742,815...1,754,476
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G |
Flt1 |
Fms related receptor tyrosine kinase 1 |
severity |
ISO |
|
RGD |
PMID:28302172 |
RGD:32716376 |
NCBI chr12:7,296,899...7,468,626
Ensembl chr12:7,297,292...7,468,626
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G |
Galc |
galactosylceramidase |
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ISO |
associated with Guillain-Barre syndrome; protein:increased expression:serum (human) associated with Guillain-Barre syndrome; protein:increased expression:Cerebrospinal fluid, serum (human) protein:increased expression:serum (mouse) |
RGD |
PMID:27490360 PMID:29301655 PMID:30396892 PMID:30396892 PMID:12225900 |
RGD:38599168, RGD:38599172, RGD:38599171, RGD:38599171, RGD:38599169 |
NCBI chr 6:117,452,888...117,522,281
Ensembl chr 6:117,452,895...117,515,830
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G |
Hdc |
histidine decarboxylase |
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ISO |
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RGD |
PMID:17158962 |
RGD:5143920 |
NCBI chr 3:113,847,256...113,865,334
Ensembl chr 3:113,847,260...113,865,341
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G |
Htra3 |
HtrA serine peptidase 3 |
severity |
ISO |
|
RGD |
PMID:28302172 |
RGD:32716376 |
NCBI chr14:75,068,917...75,097,315
Ensembl chr14:75,068,917...75,097,315
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G |
Ifng |
interferon gamma |
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ISO |
mRNA:increased expression:lung: |
RGD |
PMID:7935058 |
RGD:10755754 |
NCBI chr 7:53,903,339...53,907,375
Ensembl chr 7:53,903,337...53,907,375
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G |
Il13 |
interleukin 13 |
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ISO |
protein:increased expression:serum |
RGD |
PMID:20416219 |
RGD:4145765 |
NCBI chr10:37,790,130...37,792,687
Ensembl chr10:37,790,130...37,792,737
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G |
Il22ra2 |
interleukin 22 receptor subunit alpha 2 |
severity |
ISO |
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RGD |
PMID:28302172 |
RGD:32716376 |
NCBI chr 1:14,353,736...14,377,844
Ensembl chr 1:14,364,489...14,377,844
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G |
Inhba |
inhibin subunit beta A |
severity |
ISO |
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RGD |
PMID:28302172 |
RGD:32716376 |
NCBI chr17:49,091,635...49,111,573
Ensembl chr17:49,095,920...49,108,982
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G |
Klrb1 |
killer cell lectin like receptor B1 |
severity |
ISO |
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RGD |
PMID:28302172 |
RGD:32716376 |
NCBI chr 4:162,456,294...162,474,989
Ensembl chr 4:162,456,294...162,474,989
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G |
Ms4a1 |
membrane spanning 4-domains A1 |
severity |
ISO |
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RGD |
PMID:28302172 |
RGD:32716376 |
NCBI chr 1:207,906,370...207,927,028
Ensembl chr 1:207,906,374...207,918,512
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G |
Pld4 |
phospholipase D family, member 4 |
severity |
ISO |
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RGD |
PMID:28302172 |
RGD:32716376 |
NCBI chr 6:131,818,860...131,827,457
Ensembl chr 6:131,818,860...131,826,376
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G |
Spib |
Spi-B transcription factor |
severity |
ISO |
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RGD |
PMID:28302172 |
RGD:32716376 |
NCBI chr 1:95,018,939...95,024,804
Ensembl chr 1:95,018,947...95,024,780
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G |
Tcf7 |
transcription factor 7 |
severity |
ISO |
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RGD |
PMID:28302172 |
RGD:32716376 |
NCBI chr10:36,423,443...36,454,350
Ensembl chr10:36,423,445...36,453,535
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G |
Tcl1a |
Tcl1 family Akt coactivator A |
severity |
ISO |
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RGD |
PMID:28302172 |
RGD:32716376 |
NCBI chr 6:124,125,032...124,131,025
Ensembl chr 6:124,125,032...124,131,025
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G |
Tnf |
tumor necrosis factor |
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ISO |
protein:increased expression:serum |
RGD |
PMID:20416219 |
RGD:4145765 |
NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629
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G |
Tnfrsf13c |
TNF receptor superfamily member 13C |
severity |
ISO |
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RGD |
PMID:28302172 |
RGD:32716376 |
NCBI chr 7:113,736,046...113,738,523
Ensembl chr 7:113,736,055...113,738,517
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G |
Ptch1 |
patched 1 |
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ISO |
mRNA:decreased expression:epithelium of nasopharynx |
RGD |
PMID:23001130 |
RGD:150523839 |
NCBI chr17:1,542,705...1,607,730
Ensembl chr17:1,542,877...1,607,333
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G |
Adipoq |
adiponectin, C1Q and collagen domain containing |
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ISO |
protein:decreased expression:serum |
RGD |
PMID:19725899 |
RGD:5686851 |
NCBI chr11:77,721,912...77,735,644
Ensembl chr11:77,721,912...77,735,564
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G |
Alb |
albumin |
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ISO |
CTD Direct Evidence: marker/mechanism |
CTD |
PMID:19389874 |
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NCBI chr14:17,607,397...17,622,814
Ensembl chr14:17,607,381...17,622,836
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G |
Alox5ap |
arachidonate 5-lipoxygenase activating protein |
|
ISO |
protein:increased expression:nasal turbinate |
RGD |
PMID:19364335 |
RGD:5147461 |
NCBI chr12:5,748,941...5,772,986
Ensembl chr12:5,748,944...5,772,986
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G |
Cat |
catalase |
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ISO |
protein:decreased expression:plasma |
RGD |
PMID:20493834 |
RGD:5130771 |
NCBI chr 3:89,842,393...89,874,577
Ensembl chr 3:89,842,399...89,874,478
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G |
Ccl2 |
C-C motif chemokine ligand 2 |
|
ISO |
protein:increased expression:nasal turbinate, mucosa (human) |
RGD |
PMID:9865755 |
RGD:8548839 |
NCBI chr10:67,005,424...67,007,222
Ensembl chr10:67,005,424...67,007,226
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G |
Ccr2 |
C-C motif chemokine receptor 2 |
|
ISO |
mRNA:increased expression:Nasal Mucosa |
RGD |
PMID:17982926 |
RGD:4145109 |
NCBI chr 8:123,734,465...123,742,483
Ensembl chr 8:123,734,430...123,742,100
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G |
Ccr5 |
C-C motif chemokine receptor 5 |
|
ISO |
mRNA:increased expression:nasal mucosa (human) |
RGD |
PMID:17982926 |
RGD:4145109 |
NCBI chr 8:123,752,423...123,757,538
Ensembl chr 8:123,752,325...123,759,260
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G |
Cd40 |
CD40 molecule |
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ISO |
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RGD |
PMID:20226305 |
RGD:5132269 |
NCBI chr 3:153,790,372...153,805,279
Ensembl chr 3:153,790,449...153,805,534
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G |
Cd86 |
CD86 molecule |
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ISO |
protein:increased expression:nasal mucosa, dendritic cell (human) |
RGD |
PMID:17088138 |
RGD:4892343 |
NCBI chr11:64,142,193...64,200,816
Ensembl chr11:64,163,828...64,200,818
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G |
Chia |
chitinase, acidic |
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ISO |
mRNA, protein:increased expression:turbinate, mucosa (human) |
RGD |
PMID:20422678 |
RGD:5037226 |
NCBI chr 2:193,614,374...193,656,532
Ensembl chr 2:193,614,114...193,656,533
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G |
Egr1 |
early growth response 1 |
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ISO |
DNA:snp:5' utr:g.-4071A>G rs7729723 (human) |
RGD |
PMID:19833116 |
RGD:5131984 |
NCBI chr18:26,462,967...26,466,766
Ensembl chr18:26,462,981...26,466,766
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G |
F2rl1 |
F2R like trypsin receptor 1 |
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ISO |
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RGD |
PMID:17727088 |
RGD:4892590 |
NCBI chr 2:26,772,274...26,785,226
Ensembl chr 2:26,772,278...26,785,226
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G |
Gstp1 |
glutathione S-transferase pi 1 |
susceptibility |
ISO |
DNA:polymorphism:exon:p.I105V (rs1695) (human) |
RGD |
PMID:17181111 |
RGD:4142523 |
NCBI chr 1:201,337,762...201,340,230
Ensembl chr 1:201,321,672...201,340,226
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G |
Hmox1 |
heme oxygenase 1 |
|
ISO |
mRNA, protein:increased expression: nasal mucosa |
RGD |
PMID:16540907 |
RGD:4145406 |
NCBI chr19:13,466,287...13,474,082
Ensembl chr19:13,467,244...13,474,079
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G |
Icam1 |
intercellular adhesion molecule 1 |
|
ISO |
protein:increased expression:lung, endothelium (mouse) protein:increased secretion:nasopharynx (human) |
RGD |
PMID:19968652 PMID:19047814 |
RGD:4145464, RGD:4145520 |
NCBI chr 8:19,553,063...19,565,438
Ensembl chr 8:19,553,645...19,565,438
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G |
Ifngr1 |
interferon gamma receptor 1 |
|
ISO |
DNA: SNP: Leu467Pro |
RGD |
PMID:12851715 |
RGD:6480431 |
NCBI chr 1:14,333,167...14,351,799
Ensembl chr 1:14,333,187...14,351,785
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G |
Il13 |
interleukin 13 |
|
ISO |
mRNA, protein:increased expression:nasal mucosa |
RGD |
PMID:8520776 |
RGD:4782826 |
NCBI chr10:37,790,130...37,792,687
Ensembl chr10:37,790,130...37,792,737
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G |
Il17a |
interleukin 17A |
severity |
ISO |
protein:increased expression:serum |
RGD |
PMID:19226302 |
RGD:4889151 |
NCBI chr 9:23,144,402...23,147,889
Ensembl chr 9:23,144,402...23,147,889
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G |
Il18 |
interleukin 18 |
susceptibility |
ISO |
DNA:SNP:promoter:c. -607A>C (rs1946518) (human) |
RGD |
PMID:16406079 |
RGD:4889924 |
NCBI chr 8:50,904,630...50,932,887
Ensembl chr 8:50,906,960...50,932,887
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G |
Il1a |
interleukin 1 alpha |
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ISO |
DNA:polymorphism:exon:c.4845G>T (human) |
RGD |
PMID:14533660 |
RGD:4142859 |
NCBI chr 3:116,526,601...116,537,055
Ensembl chr 3:116,526,604...116,536,822
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G |
Il1r1 |
interleukin 1 receptor type 1 |
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ISO |
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RGD |
PMID:18637763 |
RGD:5037238 |
NCBI chr 9:42,504,917...42,580,958
Ensembl chr 9:42,504,735...42,579,937
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G |
Il2 |
interleukin 2 |
|
ISO |
protein:decreased expression:serum: |
RGD |
PMID:17608155 |
RGD:8662959 |
NCBI chr 2:120,004,862...120,009,566
Ensembl chr 2:120,004,862...120,009,566
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G |
Il4 |
interleukin 4 |
treatment |
ISO |
protein:increased expression:serum |
RGD |
PMID:21171297 PMID:9237816 PMID:15329007 |
RGD:5128559, RGD:7829817, RGD:7829804 |
NCBI chr10:37,771,203...37,776,750
Ensembl chr10:37,771,203...37,776,750
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G |
Il5 |
interleukin 5 |
|
ISO |
protein: increased levels: sputum |
RGD |
PMID:22186238 |
RGD:5687140 |
NCBI chr10:37,874,342...37,877,213
Ensembl chr10:37,874,342...37,877,213
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G |
Mmp2 |
matrix metallopeptidase 2 |
|
ISO |
protein:increased expression:nasal mucosa: |
RGD |
PMID:19786210 |
RGD:5130872 |
NCBI chr19:14,154,657...14,182,870
Ensembl chr19:14,154,657...14,182,870
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G |
Mmp9 |
matrix metallopeptidase 9 |
|
ISO |
protein:increased expression:nasal mucosa: |
RGD |
PMID:19786210 |
RGD:5130872 |
NCBI chr 3:153,684,158...153,692,118
Ensembl chr 3:153,683,858...153,692,120
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G |
Nos2 |
nitric oxide synthase 2 |
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ISO |
protein:increased expression:nasal mucosa |
RGD |
PMID:14587983 |
RGD:4892078 |
NCBI chr10:63,815,308...63,851,208
Ensembl chr10:63,815,308...63,851,210
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G |
Nos3 |
nitric oxide synthase 3 |
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ISO |
DNA:snp:promoter:g.-786T>C (human) |
RGD |
PMID:18086269 |
RGD:4892054 |
NCBI chr 4:10,793,834...10,814,170
Ensembl chr 4:10,793,834...10,814,166
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G |
Nr3c1 |
nuclear receptor subfamily 3, group C, member 1 |
|
ISO |
protein:altered expression:nasal mucosa |
RGD |
PMID:20185258 |
RGD:4892593 |
NCBI chr18:31,271,681...31,393,320
Ensembl chr18:31,271,681...31,393,375
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G |
Pparg |
peroxisome proliferator-activated receptor gamma |
|
ISO |
mRNA, protein:increased expression:nasal mucosa (human) |
RGD |
PMID:17116814 |
RGD:8552811 |
NCBI chr 4:148,423,102...148,548,471
Ensembl chr 4:148,423,194...148,548,468
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G |
Ptgs1 |
prostaglandin-endoperoxide synthase 1 |
|
ISO |
protein:increased expression:respiratory system epithelium |
RGD |
PMID:19364335 |
RGD:5147461 |
NCBI chr 3:19,584,015...19,605,589
Ensembl chr 3:19,584,015...19,605,586
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G |
Tbxa2r |
thromboxane A2 receptor |
treatment |
ISO |
|
RGD |
PMID:15247523 |
RGD:11059532 |
NCBI chr 7:8,383,347...8,390,753
Ensembl chr 7:8,383,378...8,388,176
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G |
Plau |
plasminogen activator, urokinase |
|
ISO |
Gene product used in treatment of disease |
RGD |
PMID:20304453 |
RGD:4891955 |
NCBI chr15:3,456,230...3,462,732
Ensembl chr15:3,456,232...3,462,775
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G |
Tnc |
tenascin C |
|
ISO |
protein:increased expression:pleura |
RGD |
PMID:10950882 |
RGD:4889594 |
NCBI chr 5:77,375,851...77,460,712
Ensembl chr 5:77,375,851...77,460,624
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G |
Trem1 |
triggering receptor expressed on myeloid cells 1 |
treatment |
IDA |
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RGD |
PMID:20819512 |
RGD:127284851 |
NCBI chr 9:12,763,819...12,779,285
Ensembl chr 9:12,763,819...12,779,203
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G |
Ada |
adenosine deaminase |
|
ISO |
protein:increased activity:pleural fluid: protein:increased activity:serum: protein:increased expression:serum: |
RGD |
PMID:21860532 PMID:1818842 PMID:1689629 PMID:18357489 |
RGD:152995280, RGD:152998934, RGD:152995292, RGD:152995288 |
NCBI chr 3:152,398,745...152,422,854
Ensembl chr 3:152,398,747...152,447,088
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G |
Ccl22 |
C-C motif chemokine ligand 22 |
|
ISO |
|
RGD |
PMID:20337996 |
RGD:4891473 |
NCBI chr19:10,257,602...10,264,373
Ensembl chr19:10,257,601...10,264,400
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G |
Ccr2 |
C-C motif chemokine receptor 2 |
|
ISO |
|
RGD |
PMID:19159432 |
RGD:4145106 |
NCBI chr 8:123,734,465...123,742,483
Ensembl chr 8:123,734,430...123,742,100
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G |
Ccr5 |
C-C motif chemokine receptor 5 |
|
ISO |
protein:increased expression:pleural fluid, natural killer cell (human) |
RGD |
PMID:19159432 |
RGD:4145106 |
NCBI chr 8:123,752,423...123,757,538
Ensembl chr 8:123,752,325...123,759,260
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G |
Foxp3 |
forkhead box P3 |
disease_progression |
ISO |
associated with human immunodeficiency virus infectious disease; |
RGD |
PMID:21303360 |
RGD:36947878 |
NCBI chr X:14,908,494...14,924,994
Ensembl chr X:14,908,494...14,923,838
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G |
Il1b |
interleukin 1 beta |
|
ISO |
DNA:polymorphism: :3953T>C (human) |
RGD |
PMID:10377182 |
RGD:4143226 |
NCBI chr 3:116,577,005...116,583,386
Ensembl chr 3:116,577,010...116,583,415
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G |
Il1rn |
interleukin 1 receptor antagonist |
|
ISO |
DNA:repeat (human) |
RGD |
PMID:10377182 |
RGD:4143226 |
NCBI chr 3:7,111,567...7,127,451
Ensembl chr 3:7,111,550...7,127,445
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G |
Il27 |
interleukin 27 |
exacerbates |
ISO |
associated with Pleural Effusion;protein:increased expression:pleural fluid (human) protein:increased expression:alveolar system (human) |
RGD |
PMID:25753767 PMID:31819557 PMID:23962500 PMID:28844060 |
RGD:126790505, RGD:126790549, RGD:126790523, RGD:126790517 |
NCBI chr 1:181,173,108...181,178,720
Ensembl chr 1:181,173,372...181,178,582
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G |
Il33 |
interleukin 33 |
|
ISO |
protein:increased expression:pleural fluid: |
RGD |
PMID:23301222 |
RGD:39939042 |
NCBI chr 1:227,701,964...227,736,374
Ensembl chr 1:227,721,435...227,736,373
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G |
Mmp9 |
matrix metallopeptidase 9 |
|
ISO |
protein:increased expression:pleura: |
RGD |
PMID:18715875 |
RGD:5129700 |
NCBI chr 3:153,684,158...153,692,118
Ensembl chr 3:153,683,858...153,692,120
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G |
Tlr4 |
toll-like receptor 4 |
|
ISO |
|
RGD |
PMID:18295348 |
RGD:4144193 |
NCBI chr 5:80,145,867...80,159,501
Ensembl chr 5:80,145,826...80,159,628
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G |
Tnc |
tenascin C |
|
ISO |
protein:increased expression:pleura |
RGD |
PMID:10950882 |
RGD:4889594 |
NCBI chr 5:77,375,851...77,460,712
Ensembl chr 5:77,375,851...77,460,624
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G |
Ada |
adenosine deaminase |
|
ISO |
|
RGD |
PMID:16860713 |
RGD:5128847 |
NCBI chr 3:152,398,745...152,422,854
Ensembl chr 3:152,398,747...152,447,088
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G |
Alox5 |
arachidonate 5-lipoxygenase |
|
IMP |
|
RGD |
PMID:9109363 |
RGD:4890429 |
NCBI chr 4:149,531,329...149,578,696
Ensembl chr 4:149,531,515...149,578,743
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G |
Anxa1 |
annexin A1 |
|
IDA |
|
RGD |
PMID:15784654 |
RGD:2306907 |
NCBI chr 1:217,861,175...217,877,205
Ensembl chr 1:217,861,175...217,877,343
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G |
Bdkrb1 |
bradykinin receptor B1 |
|
IMP |
|
RGD |
PMID:11853231 |
RGD:5129218 |
NCBI chr 6:124,510,827...124,514,475
Ensembl chr 6:124,510,870...124,513,747
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G |
Bdkrb2 |
bradykinin receptor B2 |
|
ISO IMP |
|
RGD |
PMID:15316088 PMID:9208140 |
RGD:4891029, RGD:4891041 |
NCBI chr 6:124,472,317...124,502,497
Ensembl chr 6:124,472,566...124,502,497
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G |
C3 |
complement C3 |
|
ISO |
protein:increased activity:pleural cavity |
RGD |
PMID:18256172 |
RGD:5129520 |
NCBI chr 9:2,087,437...2,114,366
Ensembl chr 9:2,087,437...2,114,429
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G |
Cat |
catalase |
|
ISO |
|
RGD |
PMID:19778612 |
RGD:5130749 |
NCBI chr 3:89,842,393...89,874,577
Ensembl chr 3:89,842,399...89,874,478
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G |
Ccl11 |
C-C motif chemokine ligand 11 |
|
ISO IMP |
protein:increased expression:pleural fluid |
RGD |
PMID:11877329 PMID:11564646 |
RGD:4145443, RGD:4145479 |
NCBI chr10:67,028,328...67,032,929
Ensembl chr10:67,028,328...67,032,926
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G |
Ccl25 |
C-C motif chemokine ligand 25 |
|
ISO |
protein:increased expression:pleural fluid |
RGD |
PMID:18056919 |
RGD:5130924 |
NCBI chr12:2,707,398...2,716,571
Ensembl chr12:2,707,398...2,716,554
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G |
Ccl5 |
C-C motif chemokine ligand 5 |
|
ISO |
protein:increased secretion:lung (mouse) |
RGD |
PMID:18672096 |
RGD:4890016 |
NCBI chr10:68,322,826...68,327,380
Ensembl chr10:68,322,829...68,327,377
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G |
Ccr3 |
C-C motif chemokine receptor 3 |
|
ISO |
associated with Mycobacterium Infections |
RGD |
PMID:17158890 |
RGD:4145643 |
NCBI chr 8:123,586,100...123,634,178
Ensembl chr 8:123,616,236...123,634,990
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G |
Csf3 |
colony stimulating factor 3 |
|
ISO |
|
RGD |
PMID:8841835 |
RGD:11039424 |
NCBI chr10:83,660,787...83,664,569
Ensembl chr10:83,661,207...83,663,603
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G |
Cxcl1 |
C-X-C motif chemokine ligand 1 |
|
ISO |
|
RGD |
PMID:14527170 |
RGD:5135449 |
NCBI chr14:17,193,364...17,195,143
Ensembl chr14:17,193,365...17,195,215
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G |
Cxcl10 |
C-X-C motif chemokine ligand 10 |
|
ISO |
|
RGD |
PMID:14527170 |
RGD:5135449 |
NCBI chr14:15,704,772...15,706,969
Ensembl chr14:15,704,758...15,706,975
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G |
Cxcl2 |
C-X-C motif chemokine ligand 2 |
|
IEP ISO |
|
RGD |
PMID:21549112 PMID:14527170 |
RGD:5135064, RGD:5135449 |
NCBI chr14:17,181,030...17,183,075
Ensembl chr14:17,181,062...17,183,075
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G |
Cxcl9 |
C-X-C motif chemokine ligand 9 |
|
ISO |
|
RGD |
PMID:14527170 |
RGD:5135449 |
NCBI chr14:15,722,868...15,727,779
Ensembl chr14:15,722,908...15,728,435
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G |
Ednra |
endothelin receptor type A |
|
ISO |
|
RGD |
PMID:15107459 |
RGD:4892325 |
NCBI chr19:30,233,540...30,303,727
Ensembl chr19:30,233,571...30,297,049
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G |
Elane |
elastase, neutrophil expressed |
|
IMP |
|
RGD |
PMID:20860667 |
RGD:10450565 |
NCBI chr 7:9,817,251...9,819,174
Ensembl chr 7:9,817,252...9,819,100
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G |
Esr1 |
estrogen receptor 1 |
|
IMP |
|
RGD |
PMID:17035596 |
RGD:4892303 |
NCBI chr 1:41,106,335...41,499,104
Ensembl chr 1:41,210,475...41,495,002
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G |
Icam1 |
intercellular adhesion molecule 1 |
|
ISO |
associated with Tuberculosis; protein:increased expression:pleural fluid, natural killer cell (human) CTD Direct Evidence: marker/mechanism protein:increased expression:bronchial epithelium (mouse) |
CTD RGD |
PMID:11181422 PMID:19714575 PMID:19056932 |
RGD:4145510, RGD:4145519 |
NCBI chr 8:19,553,063...19,565,438
Ensembl chr 8:19,553,645...19,565,438
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G |
Il10 |
interleukin 10 |
|
ISO |
CTD Direct Evidence: marker/mechanism |
CTD |
PMID:11181422 |
|
NCBI chr13:42,472,625...42,477,308
Ensembl chr13:42,472,839...42,477,313
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G |
Il15 |
interleukin 15 |
|
ISO |
|
RGD |
PMID:10823416 |
RGD:4990464 |
NCBI chr19:25,640,025...25,706,818
Ensembl chr19:25,640,251...25,706,820
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G |
Il17a |
interleukin 17A |
treatment |
IDA |
|
RGD |
PMID:21898269 |
RGD:7175307 |
NCBI chr 9:23,144,402...23,147,889
Ensembl chr 9:23,144,402...23,147,889
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G |
Il1b |
interleukin 1 beta |
|
IDA ISO IEP |
CTD Direct Evidence: marker/mechanism protein:increased expression:pleural cavity, exudate (rat) protein:increased expression:lung |
CTD RGD |
PMID:11181422 PMID:20141620 PMID:21898269 PMID:20175894 |
RGD:4142808, RGD:7175307, RGD:4142826 |
NCBI chr 3:116,577,005...116,583,386
Ensembl chr 3:116,577,010...116,583,415
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G |
Il1rn |
interleukin 1 receptor antagonist |
|
ISO |
|
RGD |
PMID:8491511 |
RGD:4143233 |
NCBI chr 3:7,111,567...7,127,451
Ensembl chr 3:7,111,550...7,127,445
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G |
Il6 |
interleukin 6 |
|
ISO |
CTD Direct Evidence: marker/mechanism |
CTD |
PMID:11181422 |
|
NCBI chr 4:5,214,602...5,219,178
Ensembl chr 4:5,213,394...5,219,178
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G |
Mpo |
myeloperoxidase |
|
ISO |
protein:increased activity:lung |
RGD |
PMID:11577999 |
RGD:5130991 |
NCBI chr10:72,594,883...72,608,862
Ensembl chr10:72,594,661...72,604,819
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G |
Nfe2l2 |
NFE2 like bZIP transcription factor 2 |
|
ISO |
|
RGD |
PMID:14673141 |
RGD:6893408 |
NCBI chr 3:60,594,239...60,621,712
Ensembl chr 3:60,594,242...60,621,737
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G |
Nos2 |
nitric oxide synthase 2 |
|
IEP IDA |
protein:increased expression:pleural cavity (rat) |
RGD |
PMID:21898269 PMID:20141620 |
RGD:7175307, RGD:4142808 |
NCBI chr10:63,815,308...63,851,208
Ensembl chr10:63,815,308...63,851,210
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G |
Pla2g6 |
phospholipase A2 group VI |
|
IEP |
|
RGD |
PMID:15003994 |
RGD:6482741 |
NCBI chr 7:110,851,378...110,891,557
Ensembl chr 7:110,851,378...110,891,114
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|
G |
Ptafr |
platelet-activating factor receptor |
treatment |
IMP |
|
RGD |
PMID:8395390 |
RGD:10043147 |
NCBI chr 5:144,765,770...144,795,057
Ensembl chr 5:144,765,976...144,795,251
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G |
Ptgs2 |
prostaglandin-endoperoxide synthase 2 |
|
IDA IEP |
|
RGD |
PMID:20141620 PMID:15740981 |
RGD:4142808, RGD:5143929 |
NCBI chr13:62,163,936...62,172,193
Ensembl chr13:62,163,932...62,172,188
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G |
Selp |
selectin P |
|
ISO |
protein:increased expression:lung CTD Direct Evidence: marker/mechanism |
CTD RGD |
PMID:11181422 PMID:21147071 |
RGD:6219005 |
NCBI chr13:76,476,229...76,511,846
Ensembl chr13:76,476,295...76,511,845
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G |
Serpine1 |
serpin family E member 1 |
susceptibility |
ISO |
associated with Familial Mediterranean Fever;DNA: DNA:polymorphism:promoter:rs1799768 (human): |
RGD |
PMID:23052617 |
RGD:13207414 |
NCBI chr12:19,601,272...19,611,657
Ensembl chr12:19,601,272...19,611,657
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G |
Tnf |
tumor necrosis factor |
|
ISO IDA |
CTD Direct Evidence: marker/mechanism |
CTD RGD |
PMID:11181422 PMID:11161459 PMID:20141620 |
RGD:4143474, RGD:4142808 |
NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629
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G |
Alox5 |
arachidonate 5-lipoxygenase |
|
ISO |
|
RGD |
PMID:12773506 |
RGD:4890419 |
NCBI chr 4:149,531,329...149,578,696
Ensembl chr 4:149,531,515...149,578,743
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G |
Aicda |
activation-induced cytidine deaminase |
|
ISO |
|
RGD |
PMID:26456931 |
RGD:11098923 |
NCBI chr 4:155,774,132...155,783,972
Ensembl chr 4:155,774,132...155,783,972
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|
G |
Alox5 |
arachidonate 5-lipoxygenase |
|
ISO |
|
RGD |
PMID:20231413 |
RGD:4890435 |
NCBI chr 4:149,531,329...149,578,696
Ensembl chr 4:149,531,515...149,578,743
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|
G |
Btk |
Bruton tyrosine kinase |
ameliorates |
ISO |
|
RGD |
PMID:30646846 |
RGD:124715470 |
NCBI chr X:97,722,796...97,762,315
Ensembl chr X:97,722,802...97,761,853
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|
G |
C3 |
complement C3 |
disease_progression |
ISO IEP |
protein:decreased expression:serum associated with Liver Cirrhosis, Experimental;protein:decreased expression:respiratory system fluid/secretion |
RGD |
PMID:20405 PMID:17956621 PMID:15972516 |
RGD:5130163, RGD:5129523, RGD:5129509 |
NCBI chr 9:2,087,437...2,114,366
Ensembl chr 9:2,087,437...2,114,429
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G |
C5 |
complement C5 |
severity |
ISO |
|
RGD |
PMID:7814608 |
RGD:5130159 |
NCBI chr 3:18,270,696...18,361,994
Ensembl chr 3:18,270,696...18,361,994
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|
G |
Ccl5 |
C-C motif chemokine ligand 5 |
susceptibility |
ISO |
|
RGD |
PMID:16455992 |
RGD:4892130 |
NCBI chr10:68,322,826...68,327,380
Ensembl chr10:68,322,829...68,327,377
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|
G |
Cd14 |
CD14 molecule |
|
ISO |
|
RGD |
PMID:17185649 |
RGD:4144788 |
NCBI chr18:28,335,522...28,337,383
Ensembl chr18:28,335,340...28,337,261
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|
G |
Chi3l1 |
chitinase 3 like 1 |
|
ISO |
protein:increased secretion:serum (human) |
RGD |
PMID:10515841 |
RGD:4892626 |
NCBI chr13:45,641,802...45,649,787
Ensembl chr13:45,641,802...45,649,787
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|
G |
Crhr1 |
corticotropin releasing hormone receptor 1 |
|
ISO |
|
RGD |
PMID:21774994 |
RGD:5147472 |
NCBI chr10:89,040,186...89,083,481
Ensembl chr10:89,040,203...89,083,481
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|
G |
Crhr2 |
corticotropin releasing hormone receptor 2 |
|
ISO |
|
RGD |
PMID:21774994 |
RGD:5147472 |
NCBI chr 4:84,222,897...84,265,924
Ensembl chr 4:84,224,002...84,265,904
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|
G |
Crp |
C-reactive protein |
disease_progression |
ISO |
|
RGD |
PMID:21281676 |
RGD:5131293 |
NCBI chr13:85,135,384...85,175,178
Ensembl chr13:85,124,977...85,175,178
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|
G |
Cxcl1 |
C-X-C motif chemokine ligand 1 |
|
ISO |
protein:increased expression:respiratory system fluid/secretion |
RGD |
PMID:20958976 |
RGD:5134957 |
NCBI chr14:17,193,364...17,195,143
Ensembl chr14:17,193,365...17,195,215
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G |
Cxcl9 |
C-X-C motif chemokine ligand 9 |
|
ISO |
protein:increased expression:lung |
RGD |
PMID:20381636 |
RGD:5135285 |
NCBI chr14:15,722,868...15,727,779
Ensembl chr14:15,722,908...15,728,435
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G |
Defb5 |
defensin beta 5 |
|
ISO |
CTD Direct Evidence: marker/mechanism |
CTD |
PMID:24894820 |
|
NCBI chr16:70,612,985...70,615,389
Ensembl chr16:70,613,146...70,615,467
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G |
Hmox1 |
heme oxygenase 1 |
|
ISO |
associated with influenza;protein:increased expression:lung |
RGD |
PMID:17348295 |
RGD:4145366 |
NCBI chr19:13,466,287...13,474,082
Ensembl chr19:13,467,244...13,474,079
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G |
Hp |
haptoglobin |
|
ISO |
|
RGD |
PMID:19396720 |
RGD:5147385 |
NCBI chr19:37,539,626...37,544,178
Ensembl chr19:37,539,627...37,544,523
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G |
Il15 |
interleukin 15 |
|
ISO |
protein:increased expression:alveolar macrophage, bronchial epithelial cell |
RGD |
PMID:17611121 |
RGD:5000755 |
NCBI chr19:25,640,025...25,706,818
Ensembl chr19:25,640,251...25,706,820
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G |
Il15ra |
interleukin 15 receptor subunit alpha |
|
ISO |
|
RGD |
PMID:17611121 |
RGD:5000755 |
NCBI chr17:66,802,300...66,831,973
Ensembl chr17:66,802,334...66,832,278
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G |
Il17a |
interleukin 17A |
|
ISO |
|
RGD |
PMID:19995896 |
RGD:4888531 |
NCBI chr 9:23,144,402...23,147,889
Ensembl chr 9:23,144,402...23,147,889
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G |
Il18 |
interleukin 18 |
|
ISO |
|
RGD |
PMID:15770015 |
RGD:4889960 |
NCBI chr 8:50,904,630...50,932,887
Ensembl chr 8:50,906,960...50,932,887
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G |
Il6 |
interleukin 6 |
|
ISO |
|
RGD |
PMID:20643849 |
RGD:4143255 |
NCBI chr 4:5,214,602...5,219,178
Ensembl chr 4:5,213,394...5,219,178
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G |
Lep |
leptin |
|
ISO |
|
RGD |
PMID:17822444 |
RGD:5128869 |
NCBI chr 4:57,661,127...57,675,262
Ensembl chr 4:57,661,131...57,675,262
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G |
Lepr |
leptin receptor |
|
ISO |
|
RGD |
PMID:21148797 |
RGD:5128846 |
NCBI chr 5:116,294,409...116,477,904
Ensembl chr 5:116,289,823...116,475,908
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G |
Mapk1 |
mitogen activated protein kinase 1 |
|
ISO |
CTD Direct Evidence: marker/mechanism |
CTD |
PMID:24894820 |
|
NCBI chr11:83,957,813...84,023,629
Ensembl chr11:83,957,813...84,023,616
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G |
Mapk3 |
mitogen activated protein kinase 3 |
|
ISO |
CTD Direct Evidence: marker/mechanism |
CTD |
PMID:24894820 |
|
NCBI chr 1:181,366,646...181,372,863
Ensembl chr 1:181,366,637...181,372,863
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G |
Masp2 |
MBL associated serine protease 2 |
|
ISO |
CTD Direct Evidence: marker/mechanism |
CTD |
PMID:12904520 |
|
NCBI chr 5:159,035,892...159,049,561
Ensembl chr 5:159,035,911...159,049,580
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G |
Mbl2 |
mannose binding lectin 2 |
no_association |
ISO |
DNA:mutations:5' utr, exon:multiple (human) DNA:polymorphisms:5' utr, exon:multiple (human) |
RGD |
PMID:18641104 PMID:12047967 |
RGD:4889477, RGD:4889478 |
NCBI chr 1:228,016,439...228,024,736
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G |
Nos2 |
nitric oxide synthase 2 |
|
ISO |
|
RGD |
PMID:17056580 |
RGD:4891950 |
NCBI chr10:63,815,308...63,851,208
Ensembl chr10:63,815,308...63,851,210
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|
G |
Pten |
phosphatase and tensin homolog |
ameliorates |
ISO |
myeloid knockout |
RGD |
PMID:20505137 |
RGD:127285597 |
NCBI chr 1:230,630,443...230,697,070
Ensembl chr 1:230,630,338...230,696,838
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|
G |
Sftpd |
surfactant protein D |
severity |
ISO |
|
RGD |
PMID:16255775 |
RGD:4143519 |
NCBI chr16:17,046,491...17,058,968
Ensembl chr16:17,046,483...17,059,927
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|
G |
Sirt1 |
sirtuin 1 |
|
ISO |
CTD Direct Evidence: marker/mechanism |
CTD |
PMID:24894820 |
|
NCBI chr20:25,307,225...25,329,273
Ensembl chr20:25,306,917...25,329,260
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|
G |
Sting1 |
stimulator of interferon response cGAMP interactor 1 |
|
ISO |
|
RGD |
PMID:29263110 |
RGD:39128230 |
NCBI chr18:27,332,119...27,338,371
Ensembl chr18:27,332,119...27,338,335
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|
G |
Tlr2 |
toll-like receptor 2 |
|
ISO |
|
RGD |
PMID:19956717 |
RGD:4145321 |
NCBI chr 2:169,200,620...169,206,819
Ensembl chr 2:169,197,419...169,206,630
|
|
G |
Tnf |
tumor necrosis factor |
|
ISO |
associated with influenza;protein:increased expression:lung |
RGD |
PMID:9032201 PMID:17348295 |
RGD:4143479, RGD:4145366 |
NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629
|
|
G |
Trem1 |
triggering receptor expressed on myeloid cells 1 |
ameliorates |
ISO |
|
RGD |
PMID:24752755 PMID:19596984 |
RGD:126928121, RGD:127229903 |
NCBI chr 9:12,763,819...12,779,285
Ensembl chr 9:12,763,819...12,779,203
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|
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G |
Azin1 |
antizyme inhibitor 1 |
|
IEP |
mRNA:increased expression:alveolar macrophage |
RGD |
PMID:19158080 |
RGD:14700806 |
NCBI chr 7:69,654,773...69,681,578
Ensembl chr 7:69,654,663...69,681,578
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G |
C3 |
complement C3 |
|
IEP |
|
RGD |
PMID:17169032 |
RGD:5129525 |
NCBI chr 9:2,087,437...2,114,366
Ensembl chr 9:2,087,437...2,114,429
|
|
G |
Ccl2 |
C-C motif chemokine ligand 2 |
|
ISO |
protein:increased expression:respiratory system fluid/secretion |
RGD |
PMID:20618689 |
RGD:4891428 |
NCBI chr10:67,005,424...67,007,222
Ensembl chr10:67,005,424...67,007,226
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|
G |
Cd40 |
CD40 molecule |
treatment |
ISO |
|
RGD |
PMID:10968950 |
RGD:8547797 |
NCBI chr 3:153,790,372...153,805,279
Ensembl chr 3:153,790,449...153,805,534
|
|
G |
Csf2 |
colony stimulating factor 2 |
|
IEP |
protein:increased expression:respiratory system fluid/secretion |
RGD |
PMID:19487471 |
RGD:5131475 |
NCBI chr10:38,386,945...38,388,926
Ensembl chr10:38,386,945...38,389,199
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|
G |
Il23a |
interleukin 23 subunit alpha |
|
ISO |
|
RGD |
PMID:17403873 |
RGD:39458043 |
NCBI chr 7:721,809...723,923
Ensembl chr 7:721,809...723,923
|
|
G |
Il33 |
interleukin 33 |
treatment |
ISO |
|
RGD |
PMID:21220696 |
RGD:40400892 |
NCBI chr 1:227,701,964...227,736,374
Ensembl chr 1:227,721,435...227,736,373
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G |
Muc1 |
mucin 1, cell surface associated |
|
ISO |
protein:increased expression:serum |
RGD |
PMID:9617869 |
RGD:5131424 |
NCBI chr 2:174,635,989...174,640,738
Ensembl chr 2:174,635,995...174,640,733
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G |
Nos2 |
nitric oxide synthase 2 |
|
IEP |
mRNA:increased expression:alveolar macrophage protein:decreased dimerization:alveolar macrophage |
RGD |
PMID:20377877 PMID:20558778 |
RGD:4144112, RGD:4891486 |
NCBI chr10:63,815,308...63,851,208
Ensembl chr10:63,815,308...63,851,210
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G |
RT1-Bb |
RT1 class II, locus Bb |
|
IEP |
|
RGD |
PMID:20377877 |
RGD:4144112 |
NCBI chr20:4,596,558...4,602,201
Ensembl chr20:4,596,559...4,607,597
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G |
Sftpa1 |
surfactant protein A1 |
|
ISO |
protein:increased expression:lung |
RGD |
PMID:11385364 |
RGD:4143431 |
NCBI chr16:17,008,180...17,011,686
Ensembl chr16:17,008,180...17,011,685
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G |
Sftpb |
surfactant protein B |
|
ISO |
protein:decreased expression:lung |
RGD |
PMID:11385364 |
RGD:4143431 |
NCBI chr 4:104,359,303...104,368,439
Ensembl chr 4:104,359,396...104,368,436
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G |
Sftpc |
surfactant protein C |
|
ISO |
protein:decreased expression:lung |
RGD |
PMID:11385364 |
RGD:4143431 |
NCBI chr15:45,596,565...45,599,615
Ensembl chr15:45,596,574...45,610,777
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G |
Sftpd |
surfactant protein D |
|
ISO |
protein:increased expression:lung |
RGD |
PMID:11385364 |
RGD:4143431 |
NCBI chr16:17,046,491...17,058,968
Ensembl chr16:17,046,483...17,059,927
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G |
Tlr2 |
toll-like receptor 2 |
|
ISO |
|
RGD |
PMID:18400546 |
RGD:4145341 |
NCBI chr 2:169,200,620...169,206,819
Ensembl chr 2:169,197,419...169,206,630
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G |
Abcf1 |
ATP binding cassette subfamily F member 1 |
|
ISO |
CTD Direct Evidence: marker/mechanism |
CTD |
PMID:21625544 |
|
NCBI chr20:2,802,519...2,815,433
Ensembl chr20:2,802,488...2,815,433
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G |
Abo |
ABO, alpha 1-3-N-acetylgalactosaminyltransferase and alpha 1-3-galactosyltransferase |
severity |
ISO |
DNA:polymorphism:cds:allele A (human) |
RGD |
PMID:4375858 |
RGD:39938844 |
NCBI chr 3:10,162,087...10,182,835
Ensembl chr 3:10,162,096...10,191,423
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G |
Ace |
angiotensin I converting enzyme |
disease_progression |
ISO |
associated with Hypertension |
RGD |
PMID:17727310 PMID:19455553 PMID:20051911 |
RGD:4140922, RGD:4140918, RGD:4140916 |
NCBI chr10:90,910,316...90,930,437
Ensembl chr10:90,910,316...90,931,131
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G |
Adora1 |
adenosine A1 receptor |
|
ISO |
|
RGD |
PMID:15630442 |
RGD:5129098 |
NCBI chr13:45,658,872...45,695,821
Ensembl chr13:45,658,872...45,695,801
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G |
Adora2a |
adenosine A2a receptor |
|
ISO |
associated with Lung Injury associated with Anemia, Sickle Cell |
RGD |
PMID:18703794 PMID:20798237 PMID:17601796 |
RGD:4890364, RGD:4890358, RGD:4890376 |
NCBI chr20:13,315,848...13,333,386
Ensembl chr20:13,315,853...13,333,386
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G |
Adrb2 |
adrenoceptor beta 2 |
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IDA |
|
RGD |
PMID:19925785 |
RGD:4145041 |
NCBI chr18:55,642,459...55,644,501
Ensembl chr18:55,502,903...55,644,512
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G |
Agt |
angiotensinogen |
|
ISO |
CTD Direct Evidence: therapeutic |
CTD |
PMID:28960804 |
|
NCBI chr19:52,529,139...52,549,618
Ensembl chr19:52,529,185...52,540,977
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G |
Ahr |
aryl hydrocarbon receptor |
|
ISO |
CTD Direct Evidence: marker/mechanism |
CTD |
PMID:23337360 |
|
NCBI chr 6:52,234,089...52,271,568
Ensembl chr 6:52,234,089...52,271,568
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G |
Alb |
albumin |
disease_progression |
ISO |
|
RGD |
PMID:23286966 |
RGD:11035283 |
NCBI chr14:17,607,397...17,622,814
Ensembl chr14:17,607,381...17,622,836
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G |
Bdkrb2 |
bradykinin receptor B2 |
|
ISO |
|
RGD |
PMID:15021973 |
RGD:4891030 |
NCBI chr 6:124,472,317...124,502,497
Ensembl chr 6:124,472,566...124,502,497
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G |
C3 |
complement C3 |
|
IDA |
|
RGD |
PMID:10886251 |
RGD:5129562 |
NCBI chr 9:2,087,437...2,114,366
Ensembl chr 9:2,087,437...2,114,429
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G |
C3ar1 |
complement C3a receptor 1 |
|
ISO |
associated with Respiratory Syncytial Virus Infections |
RGD |
PMID:17079327 |
RGD:5129688 |
NCBI chr 4:156,074,747...156,084,680
Ensembl chr 4:156,075,389...156,084,701
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G |
C5 |
complement C5 |
|
ISO |
associated with Respiratory Syncytial Virus Infections |
RGD |
PMID:17079327 PMID:3631740 |
RGD:5129688, RGD:5130161 |
NCBI chr 3:18,270,696...18,361,994
Ensembl chr 3:18,270,696...18,361,994
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G |
Casp1 |
caspase 1 |
|
ISO |
CTD Direct Evidence: marker/mechanism |
CTD |
PMID:21625544 |
|
NCBI chr 8:2,587,812...2,597,403
Ensembl chr 8:2,587,831...2,597,383
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G |
Ccl11 |
C-C motif chemokine ligand 11 |
|
IMP ISO IEP |
CTD Direct Evidence: marker/mechanism mRNA, protein:increased expression:lung, respiratory system fluid/secretion |
CTD RGD |
PMID:21625544 PMID:10595930 PMID:11290805 |
RGD:4145450, RGD:4145445 |
NCBI chr10:67,028,328...67,032,929
Ensembl chr10:67,028,328...67,032,926
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G |
Ccl12 |
C-C motif chemokine ligand 12 |
|
ISO |
CTD Direct Evidence: marker/mechanism |
CTD |
PMID:21625544 |
|
NCBI chr10:67,070,230...67,071,780
Ensembl chr10:67,070,230...67,071,780
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G |
Ccl17 |
C-C motif chemokine ligand 17 |
|
IEP ISO |
mRNA:increased expression:lung CTD Direct Evidence: marker/mechanism |
CTD RGD |
PMID:21625544 PMID:15993846 |
RGD:2306304 |
NCBI chr19:10,202,128...10,203,903
Ensembl chr19:10,202,128...10,203,819
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G |
Ccl19 |
C-C motif chemokine ligand 19 |
|
ISO |
CTD Direct Evidence: marker/mechanism |
CTD |
PMID:21625544 |
|
NCBI chr 5:56,963,364...56,965,308
Ensembl chr 5:56,963,364...56,965,308
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G |
Ccl2 |
C-C motif chemokine ligand 2 |
|
ISO |
protein:increased expression:respiratory system fluid/secretion CTD Direct Evidence: marker/mechanism |
CTD RGD |
PMID:21625544 PMID:19648283 |
RGD:4891461 |
NCBI chr10:67,005,424...67,007,222
Ensembl chr10:67,005,424...67,007,226
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G |
Ccl20 |
C-C motif chemokine ligand 20 |
|
ISO |
CTD Direct Evidence: marker/mechanism |
CTD |
PMID:21625544 |
|
NCBI chr 9:84,389,031...84,391,629
Ensembl chr 9:84,388,904...84,391,629
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G |
Ccl22 |
C-C motif chemokine ligand 22 |
|
IEP |
mRNA:increased expression:lung |
RGD |
PMID:15993846 |
RGD:2306304 |
NCBI chr19:10,257,602...10,264,373
Ensembl chr19:10,257,601...10,264,400
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G |
Ccl24 |
C-C motif chemokine ligand 24 |
|
ISO |
CTD Direct Evidence: marker/mechanism |
CTD |
PMID:21625544 |
|
NCBI chr12:21,100,835...21,104,832
Ensembl chr12:21,100,835...21,104,893
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G |
Ccl3 |
C-C motif chemokine ligand 3 |
|
ISO |
mRNA:increased expression:bronchoalveolar lavage (human) |
RGD |
PMID:32407669 |
RGD:30296672 |
NCBI chr10:68,451,388...68,452,938
Ensembl chr10:68,451,388...68,452,938
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G |
Ccl4 |
C-C motif chemokine ligand 4 |
|
ISO |
CTD Direct Evidence: marker/mechanism |
CTD |
PMID:21625544 |
|
NCBI chr10:68,466,394...68,468,229
Ensembl chr10:68,452,052...68,468,231
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G |
Ccl7 |
C-C motif chemokine ligand 7 |
|
ISO |
CTD Direct Evidence: marker/mechanism |
CTD RGD |
PMID:21625544 PMID:15191918 |
RGD:5130985 |
NCBI chr10:67,016,446...67,018,296
Ensembl chr10:67,016,446...67,018,303
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G |
Ccr1 |
C-C motif chemokine receptor 1 |
|
ISO |
CTD Direct Evidence: marker/mechanism |
CTD RGD |
PMID:21625544 PMID:20870892 |
RGD:5688175 |
NCBI chr 8:123,556,286...123,561,841
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G |
Ccr2 |
C-C motif chemokine receptor 2 |
|
ISO |
CTD Direct Evidence: marker/mechanism |
CTD RGD |
PMID:21625544 PMID:14615370 PMID:17284325 |
RGD:4145068, RGD:8661704 |
NCBI chr 8:123,734,465...123,742,483
Ensembl chr 8:123,734,430...123,742,100
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G |
Ccr3 |
C-C motif chemokine receptor 3 |
|
ISO |
mRNA:increased expression:lung |
RGD |
PMID:19762220 |
RGD:4145622 |
NCBI chr 8:123,586,100...123,634,178
Ensembl chr 8:123,616,236...123,634,990
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G |
Ccr5 |
C-C motif chemokine receptor 5 |
|
ISO |
Idiopathic Pneumonia Syndrome; mRNA:increased expression:lung (mouse) |
RGD |
PMID:15546955 |
RGD:4892103 |
NCBI chr 8:123,752,423...123,757,538
Ensembl chr 8:123,752,325...123,759,260
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G |
Ccr6 |
C-C motif chemokine receptor 6 |
|
ISO |
CTD Direct Evidence: marker/mechanism |
CTD |
PMID:21625544 |
|
NCBI chr 1:52,474,477...52,508,301
Ensembl chr 1:52,474,168...52,498,603
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G |
Ccr7 |
C-C motif chemokine receptor 7 |
|
ISO |
mRNA, protein:increased expression:lung |
RGD |
PMID:16394278 |
RGD:5130919 |
NCBI chr10:84,098,193...84,108,309
Ensembl chr10:84,097,381...84,108,309
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G |
Ccr9 |
C-C motif chemokine receptor 9 |
|
ISO |
CTD Direct Evidence: marker/mechanism |
CTD |
PMID:21625544 |
|
NCBI chr 8:123,396,157...123,410,199
Ensembl chr 8:123,395,813...123,413,969
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G |
Cd14 |
CD14 molecule |
|
ISO |
protein:increased expression:multiple |
RGD |
PMID:20302606 |
RGD:4144794 |
NCBI chr18:28,335,522...28,337,383
Ensembl chr18:28,335,340...28,337,261
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G |
Cd163 |
CD163 molecule |
|
ISO |
associated with liver disease;protein:increased expression:blood serum (human) |
RGD |
PMID:26339412 |
RGD:11251207 |
NCBI chr 4:157,085,080...157,118,470
Ensembl chr 4:157,085,093...157,117,878
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G |
Cd40lg |
CD40 ligand |
|
ISO |
CTD Direct Evidence: marker/mechanism |
CTD |
PMID:21625544 |
|
NCBI chr X:135,127,052...135,138,768
Ensembl chr X:135,126,969...135,138,306
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G |
Coq6 |
coenzyme Q6 monooxygenase |
|
ISO |
ClinVar Annotator: match by term: increased susceptibility to pneumonia |
ClinVar |
|
|
NCBI chr 6:104,007,814...104,019,888
Ensembl chr 6:104,007,872...104,024,657
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G |
Crhr2 |
corticotropin releasing hormone receptor 2 |
|
ISO |
|
RGD |
PMID:16855006 |
RGD:5130933 |
NCBI chr 4:84,222,897...84,265,924
Ensembl chr 4:84,224,002...84,265,904
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G |
Crp |
C-reactive protein |
severity disease_progression |
ISO |
|
RGD |
PMID:21258955 PMID:21439658 |
RGD:5131283, RGD:5131291 |
NCBI chr13:85,135,384...85,175,178
Ensembl chr13:85,124,977...85,175,178
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G |
Csf2 |
colony stimulating factor 2 |
|
ISO |
CTD Direct Evidence: marker/mechanism |
CTD RGD |
PMID:11732872 PMID:19633061 |
RGD:4142837 |
NCBI chr10:38,386,945...38,388,926
Ensembl chr10:38,386,945...38,389,199
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G |
Csf3r |
colony stimulating factor 3 receptor |
|
ISO |
mRNA:increased expression:bronchoalveolar lavage (human) |
RGD |
PMID:32407669 |
RGD:30296672 |
NCBI chr 5:138,298,605...138,318,224
Ensembl chr 5:138,301,506...138,317,881
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G |
Csk |
C-terminal Src kinase |
|
ISO |
|
RGD |
PMID:14975240 |
RGD:5134363 |
NCBI chr 8:58,029,748...58,048,742
Ensembl chr 8:58,029,749...58,048,292
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G |
Cx3cl1 |
C-X3-C motif chemokine ligand 1 |
|
ISO |
CTD Direct Evidence: marker/mechanism |
CTD |
PMID:21625544 |
|
NCBI chr19:10,227,337...10,237,826
Ensembl chr19:10,227,340...10,236,833
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G |
Cxcl1 |
C-X-C motif chemokine ligand 1 |
|
IEP ISO |
mRNA, protein:increased expression:lung CTD Direct Evidence: marker/mechanism |
CTD RGD |
PMID:21625544 PMID:20728373 |
RGD:5134959 |
NCBI chr14:17,193,364...17,195,143
Ensembl chr14:17,193,365...17,195,215
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G |
Cxcl10 |
C-X-C motif chemokine ligand 10 |
|
ISO |
associated with Lupus Erythematosus, Systemic;mRNA:increased expression:lung |
RGD |
PMID:15265940 PMID:14979941 |
RGD:5135445, RGD:5135491 |
NCBI chr14:15,704,772...15,706,969
Ensembl chr14:15,704,758...15,706,975
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G |
Cxcl2 |
C-X-C motif chemokine ligand 2 |
|
IEP ISO |
mRNA, protein:increased expression:lung mRNA:increased expression:lung |
RGD |
PMID:20728373 PMID:18367723 |
RGD:5134959, RGD:5135235 |
NCBI chr14:17,181,030...17,183,075
Ensembl chr14:17,181,062...17,183,075
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G |
Cxcl3 |
C-X-C motif chemokine ligand 3 |
|
ISO |
CTD Direct Evidence: marker/mechanism |
CTD |
PMID:21625544 |
|
NCBI chr14:17,287,727...17,289,451
Ensembl chr14:17,270,146...17,289,511
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G |
Cxcl6 |
C-X-C motif chemokine ligand 6 |
|
ISO |
protein:increased expression:sputum |
RGD |
PMID:18410262 |
RGD:5135259 |
NCBI chr14:17,310,790...17,312,250
Ensembl chr14:17,310,426...17,313,093
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G |
Cxcl9 |
C-X-C motif chemokine ligand 9 |
|
ISO |
protein:increased expression:serum CTD Direct Evidence: marker/mechanism |
CTD RGD |
PMID:21625544 PMID:17052299 PMID:15265940 |
RGD:5135440, RGD:5135445 |
NCBI chr14:15,722,868...15,727,779
Ensembl chr14:15,722,908...15,728,435
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G |
Cxcr2 |
C-X-C motif chemokine receptor 2 |
|
ISO |
CTD Direct Evidence: marker/mechanism |
CTD |
PMID:21625544 |
|
NCBI chr 9:75,729,493...75,735,868
Ensembl chr 9:75,729,115...75,739,425
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G |
Cxcr3 |
C-X-C motif chemokine receptor 3 |
|
ISO |
CTD Direct Evidence: marker/mechanism associated with Lupus Erythematosus, Systemic;mRNA:increased expression:lung |
CTD RGD |
PMID:21625544 PMID:15265940 PMID:14979941 |
RGD:5135445, RGD:5135491 |
NCBI chr X:66,844,318...66,846,969
Ensembl chr X:66,844,318...66,846,969
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G |
Cyp1a1 |
cytochrome P450, family 1, subfamily a, polypeptide 1 |
susceptibility |
ISO |
DNA:polymorphism (human) |
RGD |
PMID:15928955 |
RGD:4142512 |
NCBI chr 8:58,096,021...58,102,130
Ensembl chr 8:58,096,077...58,102,125
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|
G |
Cyp2e1 |
cytochrome P450, family 2, subfamily e, polypeptide 1 |
|
ISO |
protein:increased expression:alveolus, epithelial cell DNA:polymorphism (human) |
RGD |
PMID:14698565 PMID:15928955 |
RGD:4892223, RGD:4142512 |
NCBI chr 1:195,840,330...195,850,728
Ensembl chr 1:195,840,058...195,864,023
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G |
Defb1 |
defensin beta 1 |
|
ISO |
protein:increased expression:serum |
RGD |
PMID:17000097 |
RGD:4892262 |
NCBI chr16:70,298,862...70,313,604
Ensembl chr16:70,298,863...70,313,604
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G |
Edn1 |
endothelin 1 |
severity |
ISO |
protein:increased secretion:plasma (human) |
RGD |
PMID:20529344 |
RGD:4144879 |
NCBI chr17:22,454,924...22,460,812
Ensembl chr17:22,454,420...22,460,885
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|
G |
Egf |
epidermal growth factor |
resistance |
ISO |
|
RGD |
PMID:21701422 |
RGD:6906904 |
NCBI chr 2:218,219,408...218,302,359
Ensembl chr 2:218,219,415...218,302,064
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G |
Egr1 |
early growth response 1 |
|
ISO |
CTD Direct Evidence: therapeutic |
CTD |
PMID:29787794 |
|
NCBI chr18:26,462,967...26,466,766
Ensembl chr18:26,462,981...26,466,766
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G |
Entpd5 |
ectonucleoside triphosphate diphosphohydrolase 5 |
|
ISO |
ClinVar Annotator: match by term: increased susceptibility to pneumonia |
ClinVar |
|
|
NCBI chr 6:104,019,095...104,055,311
Ensembl chr 6:104,019,185...104,055,530
|
|
G |
Fcgr3a |
Fc gamma receptor 3A |
treatment |
ISO |
associated with Hodgkin Disease;DNA:SNP:exon:p.F158V (rs396991) (human) |
RGD |
PMID:20423913 |
RGD:11352258 |
NCBI chr13:83,249,905...83,259,921
Ensembl chr13:83,249,872...83,259,921
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G |
Grp |
gastrin releasing peptide |
|
ISO |
protein:increased expression:serum (human) |
RGD |
PMID:30146822 |
RGD:401700396 |
NCBI chr18:59,388,679...59,402,061
Ensembl chr18:59,388,274...59,402,061
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G |
Hdc |
histidine decarboxylase |
|
ISO |
|
RGD |
PMID:14556983 |
RGD:5143922 |
NCBI chr 3:113,847,256...113,865,334
Ensembl chr 3:113,847,260...113,865,341
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G |
Hmox1 |
heme oxygenase 1 |
susceptibility |
ISO |
CTD Direct Evidence: marker/mechanism |
CTD RGD |
PMID:16582079 PMID:16582079 |
RGD:1601608 |
NCBI chr19:13,466,287...13,474,082
Ensembl chr19:13,467,244...13,474,079
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|
G |
Icam1 |
intercellular adhesion molecule 1 |
treatment |
IEP |
associated with Reperfusion Injury |
RGD |
PMID:22882462 |
RGD:8547727 |
NCBI chr 8:19,553,063...19,565,438
Ensembl chr 8:19,553,645...19,565,438
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G |
Ifnar1 |
interferon alpha and beta receptor subunit 1 |
resistance |
ISO |
Cryptococcus (yeast) pneumonia |
RGD |
PMID:18566423 PMID:18566423 |
RGD:5490275, RGD:5490275 |
NCBI chr11:30,725,774...30,752,227
Ensembl chr11:30,725,790...30,749,979
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G |
Ifng |
interferon gamma |
|
ISO |
CTD Direct Evidence: marker/mechanism |
CTD |
PMID:21625544 |
|
NCBI chr 7:53,903,339...53,907,375
Ensembl chr 7:53,903,337...53,907,375
|
|
G |
Ikbkb |
inhibitor of nuclear factor kappa B kinase subunit beta |
treatment |
IMP ISO |
CTD Direct Evidence: marker/mechanism |
CTD RGD |
PMID:31095431 PMID:20080200 |
RGD:7495767 |
NCBI chr16:69,319,487...69,373,251
Ensembl chr16:69,319,554...69,373,250
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G |
Il10 |
interleukin 10 |
disease_progression |
ISO |
protein:increased expression:blood |
RGD |
PMID:20595152 |
RGD:4140400 |
NCBI chr13:42,472,625...42,477,308
Ensembl chr13:42,472,839...42,477,313
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|
G |
Il13 |
interleukin 13 |
|
ISO |
associated with Respiratory Distress Syndrome, Newborn; protein:increased expression:bronchoalveolar lavage fluid CTD Direct Evidence: marker/mechanism |
CTD RGD |
PMID:21625544 PMID:19695190 |
RGD:4145774 |
NCBI chr10:37,790,130...37,792,687
Ensembl chr10:37,790,130...37,792,737
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G |
Il13ra2 |
interleukin 13 receptor subunit alpha 2 |
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ISO |
mRNA:increased expression:lung, fibroblast |
RGD |
PMID:15161635 |
RGD:4890021 |
NCBI chr X:111,002,590...111,074,053
Ensembl chr X:111,002,592...111,072,381
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G |
Il17a |
interleukin 17A |
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ISO |
CTD Direct Evidence: marker/mechanism |
CTD RGD |
PMID:21625544 PMID:20498020 PMID:22848348 |
RGD:4888524, RGD:9068417 |
NCBI chr 9:23,144,402...23,147,889
Ensembl chr 9:23,144,402...23,147,889
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G |
Il18 |
interleukin 18 |
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ISO IEP |
protein:increased expression:serum CTD Direct Evidence: marker/mechanism associated with reperfusion injury mRNA, protein:increased expression:lung,bronchoalveolar fluid |
CTD RGD |
PMID:21625544 PMID:15955140 PMID:16052682 PMID:11739527 PMID:17400729 |
RGD:4889836, RGD:4889825, RGD:729357, RGD:4889590 |
NCBI chr 8:50,904,630...50,932,887
Ensembl chr 8:50,906,960...50,932,887
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