RGD DISEASE ONTOLOGY - ANNOTATIONS
RGD uses the Human Disease Ontology (DO, https://disease-ontology.org/) for disease curation across species. RGD automatically downloads each new release of the ontology on a monthly basis. Some additional terms which are required for RGD's curation purposes but are not currently covered in the official version of DO have been added. As corresponding terms are added to DO, these custom terms are retired and the DO terms substituted in existing annotations and subsequently used for curation.
Term: Radiation Pneumonitis
Accession: DOID:9008604
browse the term
Definition: Inflammation of the lung due to harmful effects of ionizing or non-ionizing radiation.
Synonyms: exact_synonym: Radiation Fibrosis; Radiation Pneumonia; Radiation Pneumonias; Radiation Pneumonitides
primary_id: MESH:D017564
xref: EFO:1001411
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ALOX5
arachidonate 5-lipoxygenase
ISO
RGD
PMID:1886988
RGD:4890434
NCBI chr10:45,374,216...45,446,117
Ensembl chr10:45,374,176...45,446,119
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ATM
ATM serine/threonine kinase
susceptibility
IAGP
associated with lung cancer;DNA:SNPs:promoter:���111G>A,126713G>A (rs189037, s373759) (human)
RGD
PMID:20171797
RGD:150340755
NCBI chr11:108,223,067...108,369,102
Ensembl chr11:108,222,804...108,369,102
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C3
complement C3
IEP
Protein: increased expression: plasma
RGD
PMID:20510197
RGD:5129484
NCBI chr19:6,677,704...6,720,650
Ensembl chr19:6,677,704...6,730,562
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C4BPA
complement component 4 binding protein alpha
IEP
Protein: increased expression: plasma
RGD
PMID:20510197
RGD:5129484
NCBI chr 1:207,104,233...207,144,972
Ensembl chr 1:207,104,233...207,144,972
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CBLB
Cbl proto-oncogene B
susceptibility
IAGP
associated with lung non-small cell carcinoma; DNA:SNP,haplotype: :rs2305035(human)
RGD
PMID:26732495
RGD:150540334
NCBI chr 3:105,655,461...105,869,449
Ensembl chr 3:105,655,461...105,869,552
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CCL17
C-C motif chemokine ligand 17
ISO
mRNA, protein:increased expression:lung, alveolar macrophage
RGD
PMID:15293604
RGD:4145517
NCBI chr16:57,396,093...57,416,063
Ensembl chr16:57,404,767...57,416,063
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CCL22
C-C motif chemokine ligand 22
ISO
mRNA, protein:increased expression:lung, alveolar macrophage
RGD
PMID:15293604
RGD:4145517
NCBI chr16:57,357,909...57,366,189
Ensembl chr16:57,358,783...57,366,189
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IL13
interleukin 13
susceptibility
IAGP
associated with carcinoma, non-small-cell lung; DNA:SNPs: :rs20541, rs180925 (human)
RGD
PMID:20811626
RGD:5131286
NCBI chr 5:132,656,522...132,661,110
Ensembl chr 5:132,656,263...132,661,110
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IL1A
interleukin 1 alpha
susceptibility
IAGP
associated with carcinoma, non-small-cell lung: DNA:SNPs: :rs1800587,rs17561(human)
RGD
PMID:20811626
RGD:5131286
NCBI chr 2:112,773,925...112,784,493
Ensembl chr 2:112,773,925...112,784,493
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MIF
macrophage migration inhibitory factor
susceptibility
IAGP
associated with carcinoma, non-small-cell lung; DNA:SNP: :rs755622(human)
RGD
PMID:20811626
RGD:5131286
NCBI chr22:23,894,383...23,895,223
Ensembl chr22:23,894,383...23,895,227
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NOS3
nitric oxide synthase 3
susceptibility
IAGP
associated with carcinoma, non-small-cell lung;DNA:SNP:cds:c.894G>T rs1799983 (human)
RGD
PMID:20811626
RGD:5131286
NCBI chr 7:150,991,017...151,014,588
Ensembl chr 7:150,991,017...151,014,588
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SFTPD
surfactant protein D
susceptibility
IEP
RGD
PMID:20459699
RGD:4143486
NCBI chr10:79,937,740...79,982,383
Ensembl chr10:79,937,467...79,982,614
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TGFB1
transforming growth factor beta 1
susceptibility
IEP ISO IAGP
protein:increased expression:blood DNA:SNP:exon:869T>C (rs1982073) (human)
RGD
PMID:19943923 PMID:18411002 PMID:19380441
RGD:4145121 , RGD:4145278 , RGD:4145136
NCBI chr19:41,330,323...41,353,922
Ensembl chr19:41,301,587...41,353,922
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TNF
tumor necrosis factor
susceptibility
IAGP
associated with carcinoma, non-small-cell lung: DNA:SNPs: :rs1799724(human)
RGD
PMID:20811626
RGD:5131286
NCBI chr 6:31,575,565...31,578,336
Ensembl chr 6:31,575,565...31,578,336
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TNFRSF1A
TNF receptor superfamily member 1A
ISO
RGD
PMID:18347190
RGD:5131153
NCBI chr12:6,328,771...6,342,076
Ensembl chr12:6,328,757...6,342,114
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VTN
vitronectin
IEP
Protein: increased expression: plasma
RGD
PMID:20510197
RGD:5129484
NCBI chr17:28,367,284...28,370,307
Ensembl chr17:28,367,284...28,373,091
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