RGD DISEASE ONTOLOGY - ANNOTATIONS
RGD uses the Human Disease Ontology (DO, https://disease-ontology.org/) for disease curation across species. RGD automatically downloads each new release of the ontology on a monthly basis. Some additional terms which are required for RGD's curation purposes but are not currently covered in the official version of DO have been added. As corresponding terms are added to DO, these custom terms are retired and the DO terms substituted in existing annotations and subsequently used for curation.
Term: Radiation Pneumonitis
Accession: DOID:9008604
browse the term
Definition: Inflammation of the lung due to harmful effects of ionizing or non-ionizing radiation.
Synonyms: exact_synonym: Radiation Fibrosis; Radiation Pneumonia; Radiation Pneumonias; Radiation Pneumonitides
primary_id: MESH:D017564
xref: EFO:1001411
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ALOX5
arachidonate 5-lipoxygenase
ISO
RGD
PMID:1886988
RGD:4890434
NCBI chr28:2,170,920...2,218,765
Ensembl chr28:2,170,920...2,219,609
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ATM
ATM serine/threonine kinase
susceptibility
ISO
associated with lung cancer;DNA:SNPs:promoter:���111G>A,126713G>A (rs189037, s373759) (human)
RGD
PMID:20171797
RGD:150340755
NCBI chr 5:24,180,129...24,297,207
Ensembl chr 5:24,182,135...24,297,207
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B9D2
B9 domain containing 2
susceptibility
ISO
DNA:SNP:exon:869T>C (rs1982073) (human) protein:increased expression:blood
RGD
PMID:18411002 PMID:19380441 PMID:19943923
RGD:4145121 RGD:4145136 RGD:4145278
NCBI chr 1:112,621,832...112,627,726
Ensembl chr 1:112,621,633...112,643,885
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C3
complement C3
ISO
Protein: increased expression: plasma
RGD
PMID:20510197
RGD:5129484
NCBI chr20:53,566,226...53,598,365
Ensembl chr20:53,566,261...53,598,761
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C4BPA
complement component 4 binding protein alpha
ISO
Protein: increased expression: plasma
RGD
PMID:20510197
RGD:5129484
NCBI chr 7:6,239,036...6,268,934
Ensembl chr 7:6,241,102...6,268,910
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CBLB
Cbl proto-oncogene B
susceptibility
ISO
associated with lung non-small cell carcinoma; DNA:SNP,haplotype: :rs2305035(human)
RGD
PMID:26732495
RGD:150540334
NCBI chr33:11,255,453...11,665,755
Ensembl chr33:11,199,863...11,530,810
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CCL17
C-C motif chemokine ligand 17
ISO
mRNA, protein:increased expression:lung, alveolar macrophage
RGD
PMID:15293604
RGD:4145517
NCBI chr 2:59,001,463...59,014,347
Ensembl chr 2:59,001,464...59,005,230
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CCL22
C-C motif chemokine ligand 22
ISO
mRNA, protein:increased expression:lung, alveolar macrophage
RGD
PMID:15293604
RGD:4145517
NCBI chr 2:59,039,650...59,045,519
Ensembl chr 2:59,040,539...59,045,625
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IL13
interleukin 13
susceptibility
ISO
associated with carcinoma, non-small-cell lung; DNA:SNPs: :rs20541, rs180925 (human)
RGD
PMID:20811626
RGD:5131286
NCBI chr11:20,957,870...20,961,391
Ensembl chr11:20,958,464...20,961,388
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IL1A
interleukin 1 alpha
susceptibility
ISO
associated with carcinoma, non-small-cell lung: DNA:SNPs: :rs1800587,rs17561(human)
RGD
PMID:20811626
RGD:5131286
NCBI chr17:36,969,581...36,979,445
Ensembl chr17:36,970,573...36,979,435
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MIF
macrophage migration inhibitory factor
susceptibility
ISO
associated with carcinoma, non-small-cell lung; DNA:SNP: :rs755622(human)
RGD
PMID:20811626
RGD:5131286
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NOS3
nitric oxide synthase 3
susceptibility
ISO
associated with carcinoma, non-small-cell lung;DNA:SNP:cds:c.894G>T rs1799983 (human)
RGD
PMID:20811626
RGD:5131286
NCBI chr16:15,054,196...15,072,454
Ensembl chr16:15,011,344...15,072,277
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SFTPD
surfactant protein D
susceptibility
ISO
RGD
PMID:20459699
RGD:4143486
NCBI chr 4:29,394,755...29,407,499
Ensembl chr 4:29,394,678...29,407,293
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TNF
tumor necrosis factor
susceptibility
ISO
associated with carcinoma, non-small-cell lung: DNA:SNPs: :rs1799724(human)
RGD
PMID:20811626
RGD:5131286
NCBI chr12:1,074,561...1,076,425
Ensembl chr12:1,074,552...1,076,425
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TNFRSF1A
TNF receptor superfamily member 1A
ISO
RGD
PMID:18347190
RGD:5131153
NCBI chr27:38,641,837...38,654,693
Ensembl chr27:38,638,753...38,700,282
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VTN
vitronectin
ISO
Protein: increased expression: plasma
RGD
PMID:20510197
RGD:5129484
NCBI chr 9:42,617,860...42,620,825
Ensembl chr 9:42,614,941...42,630,864
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