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RGD DISEASE ONTOLOGY - ANNOTATIONS

RGD uses the Human Disease Ontology (DO, https://disease-ontology.org/) for disease curation across species. RGD automatically downloads each new release of the ontology on a monthly basis. Some additional terms which are required for RGD's curation purposes but are not currently covered in the official version of DO have been added. As corresponding terms are added to DO, these custom terms are retired and the DO terms substituted in existing annotations and subsequently used for curation.
Term:Bacterial Lung Diseases
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Accession:DOID:9008559 term browser browse the term
Definition:Pulmonary diseases caused by bacterial infections.
Synonyms:primary_id: RDO:9002453

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Bacterial Lung Diseases term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cxcl8 C-X-C motif chemokine ligand 8 severity ISO protein:increased expression:nasal mucus (human) RGD PMID:24211414 RGD:40925940 NCBI chrNW_004624730:1,744,097...1,747,206
Ensembl chrNW_004624730:1,743,916...1,747,293 		JBrowse link
G Marco macrophage receptor with collagenous structure disease_progression ISO association with Cryptococcal neoformans infection. RGD PMID:28298522 RGD:41412191 NCBI chrNW_004624732:26,203,345...26,236,001
Ensembl chrNW_004624732:26,203,219...26,236,057 		JBrowse link
aspiration pneumonia term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ace angiotensin I converting enzyme ISO associated with Cerebrovascular Accident RGD PMID:14990394 RGD:4140926 NCBI chrNW_004624849:998,262...1,019,305
Ensembl chrNW_004624849:998,277...1,019,521 		JBrowse link
G Edn1 endothelin 1 ISO protein:increased secretion:plasma (rat) RGD PMID:19262391 RGD:4145069 NCBI chrNW_004624756:13,842,482...13,849,003
Ensembl chrNW_004624756:13,842,164...13,849,029 		JBrowse link
G Il1a interleukin 1 alpha ISO protein:increased expression:Bronchoalveolar Lavage Fluid RGD PMID:18042282 RGD:4142854 NCBI chrNW_004624749:12,795,967...12,805,658
Ensembl chrNW_004624749:12,795,946...12,805,154 		JBrowse link
G Nos2 nitric oxide synthase 2 ISO CTD Direct Evidence: marker/mechanism CTD PMID:15607125 NCBI chrNW_004624786:491,944...530,427
Ensembl chrNW_004624786:489,311...528,271 		JBrowse link
G Tnf tumor necrosis factor ISO protein:increased expression:Bronchoalveolar Lavage Fluid RGD PMID:18042282 RGD:4142854 NCBI chrNW_004624754:24,623,059...24,625,647
Ensembl chrNW_004624754:24,623,425...24,625,531 		JBrowse link
bacterial pneumonia term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcc1 ATP binding cassette subfamily C member 1 (ABCC1 blood group) ISO RGD PMID:11238654 RGD:5128828 NCBI chrNW_004624782:449,217...590,306
Ensembl chrNW_004624782:449,288...591,310 		JBrowse link
G Ace2 angiotensin converting enzyme 2 ISO associated with Pseudomonas Infections;mRNA, protein:altered expression, altered activity:lung (mouse) RGD PMID:31645418 RGD:40818279 NCBI chrNW_004624829:344,823...391,451
Ensembl chrNW_004624829:344,933...391,527 		JBrowse link
G Ager advanced glycosylation end-product specific receptor severity ISO RGD PMID:21629785 RGD:6767559 NCBI chrNW_004624754:24,138,086...24,140,900 JBrowse link
G C3 complement C3 ISO RGD PMID:16014897 RGD:5129508 NCBI chrNW_004624828:3,773,816...3,798,077
Ensembl chrNW_004624828:3,770,221...3,797,946 		JBrowse link
G C3ar1 complement C3a receptor 1 ISO RGD PMID:16461429 RGD:5129690 NCBI chrNW_004624860:5,196,621...5,204,686
Ensembl chrNW_004624860:5,197,619...5,199,043 		JBrowse link
G Cat catalase ISO protein:decreased expression:lung, plasma RGD PMID:19842849 RGD:5130748 NCBI chrNW_004624767:12,680,940...12,715,468
Ensembl chrNW_004624767:12,680,953...12,715,739 		JBrowse link
G Ccl19 C-C motif chemokine ligand 19 ISO mRNA, protein:increased expression:lung RGD PMID:20176793 RGD:5130918 NCBI chrNW_004624736:39,088,741...39,090,745
Ensembl chrNW_004624736:39,088,921...39,090,394 		JBrowse link
G Ccr7 C-C motif chemokine receptor 7 ISO RGD PMID:20176793 RGD:5130918 NCBI chrNW_004624795:2,777,766...2,787,664
Ensembl chrNW_004624795:2,779,627...2,788,897 		JBrowse link
G Cd14 CD14 molecule ISO RGD PMID:16210672 RGD:4144197 NCBI chrNW_004624743:33,372,023...33,374,438
Ensembl chrNW_004624743:33,367,898...33,373,922 		JBrowse link
G Cd40 CD40 molecule ISO RGD PMID:20102413 RGD:5132268 NCBI chrNW_004624790:8,475,640...8,485,927
Ensembl chrNW_004624790:8,476,158...8,485,856 		JBrowse link
G Cd80 CD80 molecule ISO RGD PMID:20949109 RGD:4892562 NCBI chrNW_004624731:28,630,540...28,655,297
Ensembl chrNW_004624731:28,630,446...28,651,994 		JBrowse link
G Chuk component of inhibitor of nuclear factor kappa B kinase complex ISO RGD PMID:18643924 RGD:5133701 NCBI chrNW_004624737:12,022,081...12,052,128
Ensembl chrNW_004624737:12,022,419...12,052,131 		JBrowse link
G Csf3 colony stimulating factor 3 disease_progression
treatment		 ISO associated with Peritonitis; RGD PMID:12352049 PMID:21373266 RGD:11039437 RGD:5133733 NCBI chrNW_004624795:3,162,999...3,167,248
Ensembl chrNW_004624795:3,163,009...3,166,594 		JBrowse link
G Csf3r colony stimulating factor 3 receptor disease_progression ISO RGD PMID:17185469 RGD:5133739 NCBI chrNW_004624764:19,356,848...19,396,209
Ensembl chrNW_004624764:19,356,361...19,367,860 		JBrowse link
G Cxcl10 C-X-C motif chemokine ligand 10 severity ISO RGD PMID:15618188 PMID:16299319 RGD:5135458 RGD:5135459 NCBI chrNW_004624757:14,989,241...14,991,650
Ensembl chrNW_004624757:14,989,084...14,991,910 		JBrowse link
G Cxcl11 C-X-C motif chemokine ligand 11 ISO RGD PMID:15618188 RGD:5135459 NCBI chrNW_004624757:14,952,966...14,954,343
Ensembl chrNW_004624757:14,952,851...14,954,905 		JBrowse link
G Cxcl9 C-X-C motif chemokine ligand 9 ISO RGD PMID:15618188 RGD:5135459 NCBI chrNW_004624757:14,995,649...15,009,771
Ensembl chrNW_004624757:14,995,716...15,011,893 		JBrowse link
G Cxcr3 C-X-C motif chemokine receptor 3 ISO RGD PMID:15618188 RGD:5135459 NCBI chrNW_004624903:1,958,323...1,961,789
Ensembl chrNW_004624903:1,958,698...1,961,763 		JBrowse link
G F2 coagulation factor II, thrombin ISO protein:increased expression:lung RGD PMID:21897338 RGD:6893486 NCBI chrNW_004624767:1,876,974...1,887,720
Ensembl chrNW_004624767:1,877,024...1,887,958 		JBrowse link
G Foxp3 forkhead box P3 severity ISO RGD PMID:25398094 RGD:38501102 NCBI chrNW_004624893:995,145...1,008,492
Ensembl chrNW_004624893:995,182...1,008,679 		JBrowse link
G Gp1ba glycoprotein Ib platelet subunit alpha exacerbates ISO associated with Escherichia Coli Infections RGD PMID:27845343 RGD:42722624 NCBI chrNW_004624786:8,789,496...8,794,897 JBrowse link
G Grk2 G protein-coupled receptor kinase 2 ISO mRNA:decreased expression:polymorphonuclear leukocyte RGD PMID:24465168 RGD:126848796 NCBI chrNW_004624767:19,212,218...19,231,218
Ensembl chrNW_004624767:19,210,965...19,231,082 		JBrowse link
G Icam1 intercellular adhesion molecule 1 ISO protein:increased expression:lung (mouse) RGD PMID:19846873 RGD:4145490 NCBI chrNW_004624828:2,432,584...2,451,997
Ensembl chrNW_004624828:2,432,550...2,453,071 		JBrowse link
G Ifnar1 interferon alpha and beta receptor subunit 1 severity ISO RGD PMID:19487810 RGD:5490274 NCBI chrNW_004624745:21,545,846...21,569,719
Ensembl chrNW_004624745:21,546,007...21,572,776 		JBrowse link
G Ifng interferon gamma severity ISO RGD PMID:25398094 RGD:38501102 NCBI chrNW_004624802:163,261...166,534
Ensembl chrNW_004624802:163,261...166,534 		JBrowse link
G Il10 interleukin 10 severity ISO RGD PMID:25398094 RGD:38501102 NCBI chrNW_004624807:4,687,249...4,691,658
Ensembl chrNW_004624807:4,687,176...4,691,732 		JBrowse link
G Il15 interleukin 15 ISO RGD PMID:17911627 RGD:5000754 NCBI chrNW_004624853:1,059,625...1,144,799
Ensembl chrNW_004624853:1,128,519...1,144,941 		JBrowse link
G Il17a interleukin 17A severity ISO RGD PMID:18802100 PMID:25398094 RGD:38501102 RGD:4889153 NCBI chrNW_004624855:3,911,349...3,914,214
Ensembl chrNW_004624855:3,911,349...3,913,136 		JBrowse link
G Il18 interleukin 18 ISO RGD PMID:17664259 RGD:4889913 NCBI chrNW_004624784:7,294,286...7,312,959
Ensembl chrNW_004624784:7,294,183...7,304,687 		JBrowse link
G Il1b interleukin 1 beta severity
treatment		 ISO associated with Agranulocytosis RGD PMID:7546648 PMID:18596024 PMID:25398094 RGD:10755357 RGD:38501102 RGD:4143205 NCBI chrNW_004624749:12,852,128...12,858,478
Ensembl chrNW_004624749:12,852,021...12,858,760 		JBrowse link
G Il1rl1 interleukin 1 receptor like 1 treatment ISO associated with Sepsis
associated with Acinetobacter infectious disease		 RGD PMID:20959556 PMID:29508184 RGD:40818077 RGD:5144223 NCBI chrNW_004624749:6,795,822...6,873,068
Ensembl chrNW_004624749:6,795,748...6,873,701 		JBrowse link
G Il1rn interleukin 1 receptor antagonist ISO RGD PMID:18322242 PMID:18596024 RGD:4143205 RGD:4143206 NCBI chrNW_004624749:13,210,365...13,224,471
Ensembl chrNW_004624749:13,210,476...13,225,890 		JBrowse link
G Il6 interleukin 6 severity ISO RGD PMID:25398094 RGD:38501102 NCBI chrNW_004624739:7,957,709...7,963,414
Ensembl chrNW_004624739:7,957,674...7,962,318 		JBrowse link
G Irak3 interleukin 1 receptor associated kinase 3 ISO RGD PMID:20439918 PMID:28120642 RGD:34888234 RGD:36049799 NCBI chrNW_004624802:2,042,486...2,098,921
Ensembl chrNW_004624802:2,047,409...2,098,545 		JBrowse link
G Irf1 interferon regulatory factor 1 ISO RGD PMID:11854220 RGD:5128725 NCBI chrNW_004624733:39,596,565...39,603,428
Ensembl chrNW_004624733:39,596,501...39,603,526 		JBrowse link
G Irf3 interferon regulatory factor 3 ISO RGD PMID:20720199 RGD:4891951 NCBI chrNW_004624832:4,611,445...4,616,319
Ensembl chrNW_004624832:4,612,374...4,616,276 		JBrowse link
G Itgb3 integrin subunit beta 3 ISO protein:increased expression:lung, neutrophil RGD PMID:15114484 RGD:4993468 NCBI chrNW_004624849:1,895,378...1,952,755
Ensembl chrNW_004624849:1,895,914...1,952,665 		JBrowse link
G Lep leptin ISO RGD PMID:11937559 RGD:5128871 NCBI chrNW_004624783:7,708,820...7,721,610
Ensembl chrNW_004624783:7,708,588...7,721,727 		JBrowse link
G Mapk8 mitogen-activated protein kinase 8 severity ISO associated with Escherichia Coli Infections RGD PMID:22514650 RGD:150340681 NCBI chrNW_004624928:1,442,216...1,494,275
Ensembl chrNW_004624928:1,439,146...1,494,266 		JBrowse link
G Mbl2 mannose binding lectin 2 ISO Legionella Pneumonia; DNA:mutations:5' utr, exon:multiple (human) RGD PMID:18641104 RGD:4889477 NCBI chrNW_004624791:10,881,319...10,886,294
Ensembl chrNW_004624791:10,881,268...10,886,297 		JBrowse link
G Mc1r melanocortin 1 receptor ISO RGD PMID:18304533 RGD:5687324 NCBI chrNW_004624746:131,356...137,745
Ensembl chrNW_004624746:132,904...133,860 		JBrowse link
G Mmp9 matrix metallopeptidase 9 ISO protein:increased expression:bronchoalveolar lavage fluid RGD PMID:17202364 PMID:19535150 RGD:5129533 RGD:5130727 NCBI chrNW_004624790:8,584,399...8,591,763
Ensembl chrNW_004624790:8,583,457...8,591,713 		JBrowse link
G Mpo myeloperoxidase ISO protein:increased activity:bronchoalveolar lavage Fluid: RGD PMID:11269653 RGD:5130992 NCBI chrNW_004624871:121,026...131,433
Ensembl chrNW_004624871:121,026...131,323 		JBrowse link
G Nod1 nucleotide binding oligomerization domain containing 1 ISO RGD PMID:19360122 RGD:5131449 NCBI chrNW_004624739:285,791...339,752
Ensembl chrNW_004624739:285,689...341,956 		JBrowse link
G Nod2 nucleotide binding oligomerization domain containing 2 ISO RGD PMID:19360122 RGD:5131449 NCBI chrNW_004624757:5,956,873...6,000,052
Ensembl chrNW_004624757:5,958,486...6,000,103 		JBrowse link
G Pdpn podoplanin ISO protein:increased expression:lung RGD PMID:7864138 RGD:2292375 NCBI chrNW_004624764:163,370...192,770 JBrowse link
G Pecam1 platelet and endothelial cell adhesion molecule 1 ISO protein:decreased expression:lung RGD PMID:12524254 RGD:724645 NCBI chrNW_004624870:33,293...122,536 JBrowse link
G Pgf placental growth factor ISO protein:increased expression:plasma RGD PMID:16702604 RGD:6483601 NCBI chrNW_004624734:26,751,986...26,764,154
Ensembl chrNW_004624734:26,751,530...26,764,242 		JBrowse link
G Pten phosphatase and tensin homolog ameliorates ISO myeloid knockout RGD PMID:21527775 RGD:127285594 NCBI chrNW_004624791:13,975,235...14,056,900 JBrowse link
G Ripk3 receptor interacting serine/threonine kinase 3 ameliorates ISO RGD PMID:28387756 RGD:127229944 NCBI chrNW_004624820:8,165,546...8,169,172 JBrowse link
G Rorc RAR related orphan receptor C severity ISO RGD PMID:25398094 RGD:38501102 NCBI chrNW_004624772:19,478,403...19,501,184
Ensembl chrNW_004624772:19,477,093...19,501,169 		JBrowse link
G Serpine1 serpin family E member 1 severity ISO RGD PMID:17032919 RGD:4144840 NCBI chrNW_004624740:16,128,145...16,136,696
Ensembl chrNW_004624740:16,128,059...16,137,337 		JBrowse link
G Sftpb surfactant protein B ISO protein:increased expression:lung
associated with Cystic Fibrosis;protein:increased expression:lung		 RGD PMID:12169586 PMID:15271694 RGD:4143403 RGD:4143464 NCBI chrNW_004624749:17,486,483...17,495,822
Ensembl chrNW_004624749:17,486,518...17,493,846 		JBrowse link
G Sftpc surfactant protein C ISO RGD PMID:12169586 PMID:18566429 RGD:4143464 RGD:4144114 NCBI chrNW_004624758:17,742,439...17,744,664
Ensembl chrNW_004624758:17,742,415...17,744,655 		JBrowse link
G Sftpd surfactant protein D ISO protein:increased expression:lung
associated with Cystic Fibrosis;protein:decreased expression:lung		 RGD PMID:12169586 PMID:15271694 RGD:4143403 RGD:4143464 NCBI chrNW_004624841:6,917,067...6,938,594
Ensembl chrNW_004624841:6,916,849...6,936,077 		JBrowse link
G Stat3 signal transducer and activator of transcription 3 ISO RGD PMID:18192501 RGD:6892945 NCBI chrNW_004624795:1,648,235...1,680,788
Ensembl chrNW_004624795:1,648,080...1,681,200 		JBrowse link
G Tgfb1 transforming growth factor beta 1 severity ISO RGD PMID:25398094 RGD:38501102 NCBI chrNW_004624907:162,567...175,696
Ensembl chrNW_004624907:161,569...176,605 		JBrowse link
G Tlr2 toll like receptor 2 ISO RGD PMID:18768871 PMID:19844782 RGD:4145337 RGD:4889533 NCBI chrNW_004624858:4,931,820...4,984,175
Ensembl chrNW_004624858:4,979,485...4,981,833 		JBrowse link
G Tlr4 toll like receptor 4 ISO RGD PMID:16210672 PMID:20650991 RGD:4144172 RGD:4144197 NCBI chrNW_004624760:17,596,516...17,608,955
Ensembl chrNW_004624760:17,598,630...17,609,120 		JBrowse link
G Tlr5 toll like receptor 5 ISO RGD PMID:19801452 RGD:5129503 NCBI chrNW_004624835:5,495,723...5,503,462
Ensembl chrNW_004624835:5,500,461...5,503,034 		JBrowse link
G Tlr6 toll like receptor 6 ISO RGD PMID:19844782 RGD:4889533 NCBI chrNW_004624840:7,323,022...7,349,334 JBrowse link
G Tnf tumor necrosis factor severity
treatment
disease_progression		 ISO associated with Agranulocytosis RGD PMID:7546648 PMID:9310939 PMID:10650487 PMID:12958055 RGD:10449451 RGD:10450564 RGD:10755357 RGD:4143476 NCBI chrNW_004624754:24,623,059...24,625,647
Ensembl chrNW_004624754:24,623,425...24,625,531 		JBrowse link
G Tnfrsf1a TNF receptor superfamily member 1A ISO protein:increased expression:serum (mouse) RGD PMID:19842848 RGD:5131429 NCBI chrNW_004624860:3,111,244...3,123,041
Ensembl chrNW_004624860:3,111,630...3,122,711 		JBrowse link
G Tnfrsf1b TNF receptor superfamily member 1B ISO protein:increased expression:serum (mouse) RGD PMID:19842848 RGD:5131429 NCBI chrNW_004624818:894,470...922,806
Ensembl chrNW_004624818:896,150...922,710 		JBrowse link
G Zc3h12a zinc finger CCCH-type containing 12A ISO associated with Pseudomonas Infections RGD PMID:29695841 RGD:39938967 NCBI chrNW_004624764:20,224,919...20,234,108
Ensembl chrNW_004624764:20,224,906...20,234,629 		JBrowse link
Chlamydia pneumonia term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cd274 CD274 molecule ISO mRNA:increased expression:lung RGD PMID:26378990 RGD:41412180 NCBI chrNW_004624736:9,991,851...10,017,047
Ensembl chrNW_004624736:9,996,156...10,013,814 		JBrowse link
G Pdcd1 programmed cell death 1 ISO mRNA:increased expression:lung RGD PMID:26378990 RGD:41412180 NCBI chrNW_004624847:5,732,922...5,741,908
Ensembl chrNW_004624847:5,732,767...5,742,269 		JBrowse link
G Pik3cd phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit delta severity ISO RGD PMID:29893841 RGD:40890270 NCBI chrNW_004624818:2,751,724...2,789,145
Ensembl chrNW_004624818:2,751,724...2,779,999 		JBrowse link
Klebsiella pneumonia term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cxcl8 C-X-C motif chemokine ligand 8 ISO RGD PMID:11207292 RGD:38549344 NCBI chrNW_004624730:1,744,097...1,747,206
Ensembl chrNW_004624730:1,743,916...1,747,293 		JBrowse link
G Il23a interleukin 23 subunit alpha severity ISO RGD PMID:16157683 RGD:39457940 NCBI chrNW_004624802:11,662,851...11,664,444
Ensembl chrNW_004624802:11,662,753...11,665,418 		JBrowse link
G Irak3 interleukin 1 receptor associated kinase 3 severity ISO mRNA:increased expression:lung (mouse) RGD PMID:20864681 PMID:22729155 RGD:35316077 RGD:36049798 NCBI chrNW_004624802:2,042,486...2,098,921
Ensembl chrNW_004624802:2,047,409...2,098,545 		JBrowse link
G Plac8 placenta associated 8 severity ISO RGD PMID:17404296 RGD:40924563 NCBI chrNW_004624900:134,075...157,982
Ensembl chrNW_004624900:133,889...158,050 		JBrowse link
Legionnaires' disease term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ada adenosine deaminase ISO protein:increased expression:serum RGD PMID:9255891 RGD:5128857 NCBI chrNW_004624790:9,809,550...9,829,199
Ensembl chrNW_004624790:9,809,492...9,829,883 		JBrowse link
G Cx3cl1 C-X3-C motif chemokine ligand 1 ISO RGD PMID:16113250 RGD:4891897 NCBI chrNW_004624746:28,677,956...28,688,638
Ensembl chrNW_004624746:28,677,709...28,689,122 		JBrowse link
G Ifng interferon gamma ISO CTD Direct Evidence: therapeutic CTD PMID:11349020 NCBI chrNW_004624802:163,261...166,534
Ensembl chrNW_004624802:163,261...166,534 		JBrowse link
G Il18 interleukin 18 ISO RGD PMID:11083766 RGD:4889865 NCBI chrNW_004624784:7,294,286...7,312,959
Ensembl chrNW_004624784:7,294,183...7,304,687 		JBrowse link
G Mbl2 mannose binding lectin 2 susceptibility ISO RGD PMID:19073229 RGD:12910934 NCBI chrNW_004624791:10,881,319...10,886,294
Ensembl chrNW_004624791:10,881,268...10,886,297 		JBrowse link
G Nod1 nucleotide binding oligomerization domain containing 1 ISO RGD PMID:20685341 RGD:5131443 NCBI chrNW_004624739:285,791...339,752
Ensembl chrNW_004624739:285,689...341,956 		JBrowse link
G Nod2 nucleotide binding oligomerization domain containing 2 ISO RGD PMID:20685341 RGD:5131443 NCBI chrNW_004624757:5,956,873...6,000,052
Ensembl chrNW_004624757:5,958,486...6,000,103 		JBrowse link
G Tlr5 toll like receptor 5 susceptibility ISO ClinVar Annotator: match by term: Legionnaire disease, susceptibility to ClinVar
OMIM		 PMID:14623910 PMID:16027372 PMID:23447684 NCBI chrNW_004624835:5,495,723...5,503,462
Ensembl chrNW_004624835:5,500,461...5,503,034 		JBrowse link
G Tnfrsf1a TNF receptor superfamily member 1A ISO RGD PMID:18838275 RGD:5131445 NCBI chrNW_004624860:3,111,244...3,123,041
Ensembl chrNW_004624860:3,111,630...3,122,711 		JBrowse link
G Tnfrsf1b TNF receptor superfamily member 1B ISO RGD PMID:18838275 RGD:5131445 NCBI chrNW_004624818:894,470...922,806
Ensembl chrNW_004624818:896,150...922,710 		JBrowse link
Mycoplasma pneumoniae pneumonia term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ada adenosine deaminase ISO protein:increased expression:serum RGD PMID:9255891 RGD:5128857 NCBI chrNW_004624790:9,809,550...9,829,199
Ensembl chrNW_004624790:9,809,492...9,829,883 		JBrowse link
G Atp1b2 ATPase Na+/K+ transporting subunit beta 2 severity ISO RGD PMID:28302172 RGD:32716376 NCBI chrNW_004624786:10,254,979...10,261,508
Ensembl chrNW_004624786:10,234,492...10,262,367 		JBrowse link
G Ccl5 C-C motif chemokine ligand 5 ISO protein:increased secretion:lung, secretion (mouse) RGD PMID:18717637 RGD:4891914 NCBI chrNW_004624875:3,334,136...3,342,085
Ensembl chrNW_004624875:3,334,078...3,341,614 		JBrowse link
G Clec5a C-type lectin domain containing 5A severity ISO RGD PMID:28302172 RGD:32716376 NCBI chrNW_004624765:21,865,583...21,874,985
Ensembl chrNW_004624765:21,864,722...21,875,013 		JBrowse link
G Col3a1 collagen type III alpha 1 chain severity ISO RGD PMID:28302172 RGD:32716376 NCBI chrNW_004624899:1,192,078...1,230,528
Ensembl chrNW_004624899:1,192,360...1,230,404 		JBrowse link
G Col6a1 collagen type VI alpha 1 chain severity ISO RGD PMID:28302172 RGD:32716376 NCBI chrNW_004624745:31,125,136...31,140,126
Ensembl chrNW_004624745:31,125,265...31,139,318 		JBrowse link
G Col6a2 collagen type VI alpha 2 chain severity ISO RGD PMID:28302172 RGD:32716376 NCBI chrNW_004624745:31,246,458...31,272,403
Ensembl chrNW_004624745:31,258,825...31,272,524 		JBrowse link
G Crp C-reactive protein ISO RGD PMID:21426633 RGD:5131292 NCBI chrNW_004624794:1,531,555...1,533,804
Ensembl chrNW_004624794:1,531,571...1,533,804 		JBrowse link
G Dnase1l3 deoxyribonuclease 1L3 severity ISO RGD PMID:28302172 RGD:32716376 NCBI chrNW_004624821:845,631...871,156
Ensembl chrNW_004624821:849,434...871,609 		JBrowse link
G Fcer2 Fc fragment of IgE receptor II severity ISO RGD PMID:28302172 RGD:32716376 NCBI chrNW_004624828:747,800...754,185
Ensembl chrNW_004624828:748,671...754,185 		JBrowse link
G Flt1 fms related receptor tyrosine kinase 1 severity ISO RGD PMID:28302172 RGD:32716376 NCBI chrNW_004624776:10,043,113...10,218,598
Ensembl chrNW_004624776:10,043,258...10,219,104 		JBrowse link
G Galc galactosylceramidase ISO associated with Guillain-Barre syndrome; protein:increased expression:serum (human)
protein:increased expression:serum (mouse)
associated with Guillain-Barre syndrome; protein:increased expression:Cerebrospinal fluid, serum (human)		 RGD PMID:12225900 PMID:27490360 PMID:29301655 PMID:30396892 RGD:38599168 RGD:38599169 RGD:38599171 RGD:38599172 NCBI chrNW_004624734:14,355,349...14,462,869
Ensembl chrNW_004624734:14,355,435...14,407,087 		JBrowse link
G Hdc histidine decarboxylase ISO RGD PMID:17158962 RGD:5143920 NCBI chrNW_004624731:9,835,585...9,856,743
Ensembl chrNW_004624731:9,835,596...9,856,743 		JBrowse link
G Htra3 HtrA serine peptidase 3 severity ISO RGD PMID:28302172 RGD:32716376 NCBI chrNW_004624755:23,950,972...23,969,700
Ensembl chrNW_004624755:23,951,134...23,969,774 		JBrowse link
G Ifng interferon gamma ISO mRNA:increased expression:lung: RGD PMID:7935058 RGD:10755754 NCBI chrNW_004624802:163,261...166,534
Ensembl chrNW_004624802:163,261...166,534 		JBrowse link
G Il13 interleukin 13 ISO protein:increased expression:serum RGD PMID:20416219 RGD:4145765 NCBI chrNW_004624733:39,427,189...39,430,019
Ensembl chrNW_004624733:39,428,095...39,429,843 		JBrowse link
G Il22ra2 interleukin 22 receptor subunit alpha 2 severity ISO RGD PMID:28302172 RGD:32716376 NCBI chrNW_004624886:650,376...659,502
Ensembl chrNW_004624886:650,373...659,502 		JBrowse link
G Inhba inhibin subunit beta A severity ISO RGD PMID:28302172 RGD:32716376 NCBI chrNW_004624740:19,458,835...19,482,570
Ensembl chrNW_004624740:19,464,289...19,482,888 		JBrowse link
G Pld4 phospholipase D family member 4 severity ISO RGD PMID:28302172 RGD:32716376 NCBI chrNW_004624734:432,069...439,078
Ensembl chrNW_004624734:431,956...438,170 		JBrowse link
G Spib Spi-B transcription factor severity ISO RGD PMID:28302172 RGD:32716376 NCBI chrNW_004624832:4,110,462...4,116,657
Ensembl chrNW_004624832:4,111,939...4,116,657 		JBrowse link
G Tcf7 transcription factor 7 severity ISO RGD PMID:28302172 RGD:32716376 NCBI chrNW_004624733:38,076,800...38,104,265
Ensembl chrNW_004624733:38,076,410...38,104,173 		JBrowse link
G Tcl1a TCL1 family AKT coactivator A severity ISO RGD PMID:28302172 RGD:32716376 NCBI chrNW_004624734:8,111,655...8,116,084 JBrowse link
G Tnf tumor necrosis factor ISO protein:increased expression:serum RGD PMID:20416219 RGD:4145765 NCBI chrNW_004624754:24,623,059...24,625,647
Ensembl chrNW_004624754:24,623,425...24,625,531 		JBrowse link
G Tnfrsf13c TNF receptor superfamily member 13C severity ISO RGD PMID:28302172 RGD:32716376 NCBI chrNW_004624752:6,797,453...6,799,437
Ensembl chrNW_004624752:6,797,983...6,799,097 		JBrowse link
Pneumococcal Pneumonia term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Aicda activation induced cytidine deaminase ISO RGD PMID:26456931 RGD:11098923 NCBI chrNW_004624860:4,912,938...4,927,846
Ensembl chrNW_004624860:4,912,656...4,926,634 		JBrowse link
G Alox5 arachidonate 5-lipoxygenase ISO RGD PMID:20231413 RGD:4890435 NCBI chrNW_004624966:168,244...220,430
Ensembl chrNW_004624966:168,250...220,522 		JBrowse link
G Btk Bruton tyrosine kinase ameliorates ISO RGD PMID:30646846 RGD:124715470 NCBI chrNW_004624902:1,173,101...1,216,662
Ensembl chrNW_004624902:1,182,682...1,216,171 		JBrowse link
G C3 complement C3 disease_progression ISO protein:decreased expression:serum
associated with Liver Cirrhosis, Experimental;protein:decreased expression:respiratory system fluid/secretion		 RGD PMID:20405 PMID:15972516 PMID:17956621 RGD:5129509 RGD:5129523 RGD:5130163 NCBI chrNW_004624828:3,773,816...3,798,077
Ensembl chrNW_004624828:3,770,221...3,797,946 		JBrowse link
G Ccl5 C-C motif chemokine ligand 5 susceptibility ISO RGD PMID:16455992 RGD:4892130 NCBI chrNW_004624875:3,334,136...3,342,085
Ensembl chrNW_004624875:3,334,078...3,341,614 		JBrowse link
G Cd14 CD14 molecule ISO RGD PMID:17185649 RGD:4144788 NCBI chrNW_004624743:33,372,023...33,374,438
Ensembl chrNW_004624743:33,367,898...33,373,922 		JBrowse link
G Chi3l1 chitinase 3 like 1 ISO protein:increased secretion:serum (human) RGD PMID:10515841 RGD:4892626 NCBI chrNW_004624807:7,655,777...7,664,484
Ensembl chrNW_004624807:7,655,620...7,662,362 		JBrowse link
G Crhr1 corticotropin releasing hormone receptor 1 ISO RGD PMID:21774994 RGD:5147472 NCBI chrNW_004624849:2,484,144...2,528,130
Ensembl chrNW_004624849:2,484,109...2,528,223 		JBrowse link
G Crhr2 corticotropin releasing hormone receptor 2 ISO RGD PMID:21774994 RGD:5147472 NCBI chrNW_004624739:114,383...161,010
Ensembl chrNW_004624739:114,342...161,044 		JBrowse link
G Crp C-reactive protein disease_progression ISO RGD PMID:21281676 RGD:5131293 NCBI chrNW_004624794:1,531,555...1,533,804
Ensembl chrNW_004624794:1,531,571...1,533,804 		JBrowse link
G Cxcl8 C-X-C motif chemokine ligand 8 ISO CTD Direct Evidence: marker/mechanism CTD PMID:24894820 NCBI chrNW_004624730:1,744,097...1,747,206
Ensembl chrNW_004624730:1,743,916...1,747,293 		JBrowse link
G Cxcl9 C-X-C motif chemokine ligand 9 ISO protein:increased expression:lung RGD PMID:20381636 RGD:5135285 NCBI chrNW_004624757:14,995,649...15,009,771
Ensembl chrNW_004624757:14,995,716...15,011,893 		JBrowse link
G Hmox1 heme oxygenase 1 ISO associated with influenza;protein:increased expression:lung RGD PMID:17348295 RGD:4145366 NCBI chrNW_004624750:341,699...346,005
Ensembl chrNW_004624750:342,146...345,887 		JBrowse link
G Il15 interleukin 15 ISO protein:increased expression:alveolar macrophage, bronchial epithelial cell RGD PMID:17611121 RGD:5000755 NCBI chrNW_004624853:1,059,625...1,144,799
Ensembl chrNW_004624853:1,128,519...1,144,941 		JBrowse link
G Il15ra interleukin 15 receptor subunit alpha ISO RGD PMID:17611121 RGD:5000755 NCBI chrNW_004624775:846,063...877,894
Ensembl chrNW_004624775:847,677...877,604 		JBrowse link
G Il17a interleukin 17A ISO RGD PMID:19995896 RGD:4888531 NCBI chrNW_004624855:3,911,349...3,914,214
Ensembl chrNW_004624855:3,911,349...3,913,136 		JBrowse link
G Il18 interleukin 18 ISO RGD PMID:15770015 RGD:4889960 NCBI chrNW_004624784:7,294,286...7,312,959
Ensembl chrNW_004624784:7,294,183...7,304,687 		JBrowse link
G Il6 interleukin 6 ISO RGD PMID:20643849 RGD:4143255 NCBI chrNW_004624739:7,957,709...7,963,414
Ensembl chrNW_004624739:7,957,674...7,962,318 		JBrowse link
G Lep leptin ISO RGD PMID:17822444 RGD:5128869 NCBI chrNW_004624783:7,708,820...7,721,610
Ensembl chrNW_004624783:7,708,588...7,721,727 		JBrowse link
G Lepr leptin receptor ISO RGD PMID:21148797 RGD:5128846 NCBI chrNW_004624742:29,221,742...29,313,273
Ensembl chrNW_004624742:29,223,392...29,337,049 		JBrowse link
G Mapk1 mitogen-activated protein kinase 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:24894820 NCBI chrNW_004624747:1,296,062...1,389,674
Ensembl chrNW_004624747:1,296,221...1,389,757 		JBrowse link
G Mapk3 mitogen-activated protein kinase 3 ISO CTD Direct Evidence: marker/mechanism CTD PMID:24894820 NCBI chrNW_004624782:13,150,824...13,158,327
Ensembl chrNW_004624782:13,152,039...13,159,113 		JBrowse link
G Masp2 MBL associated serine protease 2 ISO CTD Direct Evidence: marker/mechanism CTD PMID:12904520 NCBI chrNW_004624818:1,745,401...1,759,051 JBrowse link
G Mbl2 mannose binding lectin 2 no_association ISO DNA:polymorphisms:5' utr, exon:multiple (human)
DNA:mutations:5' utr, exon:multiple (human)		 RGD PMID:12047967 PMID:18641104 RGD:4889477 RGD:4889478 NCBI chrNW_004624791:10,881,319...10,886,294
Ensembl chrNW_004624791:10,881,268...10,886,297 		JBrowse link
G Nos2 nitric oxide synthase 2 ISO RGD PMID:17056580 RGD:4891950 NCBI chrNW_004624786:491,944...530,427
Ensembl chrNW_004624786:489,311...528,271 		JBrowse link
G Pten phosphatase and tensin homolog ameliorates ISO myeloid knockout RGD PMID:20505137 RGD:127285597 NCBI chrNW_004624791:13,975,235...14,056,900 JBrowse link
G Sftpd surfactant protein D severity ISO RGD PMID:16255775 RGD:4143519 NCBI chrNW_004624841:6,917,067...6,938,594
Ensembl chrNW_004624841:6,916,849...6,936,077 		JBrowse link
G Sirt1 sirtuin 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:24894820 NCBI chrNW_004624754:2,304,476...2,332,705
Ensembl chrNW_004624754:2,304,634...2,330,946 		JBrowse link
G Sting1 stimulator of interferon response cGAMP interactor 1 ISO RGD PMID:29263110 RGD:39128230 NCBI chrNW_004624743:32,277,197...32,283,346
Ensembl chrNW_004624743:32,273,385...32,283,235 		JBrowse link
G Tlr2 toll like receptor 2 ISO RGD PMID:19956717 RGD:4145321 NCBI chrNW_004624858:4,931,820...4,984,175
Ensembl chrNW_004624858:4,979,485...4,981,833 		JBrowse link
G Tnf tumor necrosis factor ISO associated with influenza;protein:increased expression:lung RGD PMID:9032201 PMID:17348295 RGD:4143479 RGD:4145366 NCBI chrNW_004624754:24,623,059...24,625,647
Ensembl chrNW_004624754:24,623,425...24,625,531 		JBrowse link
pneumonic tularemia term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ido1 indoleamine 2,3-dioxygenase 1 ISO RGD PMID:20385761 RGD:39938865 NCBI chrNW_004624780:3,684,941...3,697,506
Ensembl chrNW_004624780:3,685,069...3,697,474 		JBrowse link
Staphylococcal Pneumonia term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Akt1 AKT serine/threonine kinase 1 treatment ISO RGD PMID:23613163 RGD:38676477 NCBI chrNW_004624734:507,880...525,295
Ensembl chrNW_004624734:509,368...525,295 		JBrowse link
G Cd86 CD86 molecule ISO protein:decreased expression:spleen, plasmacytoid dendritic cell (mouse) RGD PMID:20949109 RGD:4892562 NCBI chrNW_004624912:350,201...432,410
Ensembl chrNW_004624912:350,157...426,712 		JBrowse link
G Cftr CF transmembrane conductance regulator ISO RGD PMID:28289144 RGD:36049750 NCBI chrNW_004624827:1,704,733...1,893,579 JBrowse link
G Csf3 colony stimulating factor 3 treatment ISO RGD PMID:10228098 RGD:11039478 NCBI chrNW_004624795:3,162,999...3,167,248
Ensembl chrNW_004624795:3,163,009...3,166,594 		JBrowse link
G Fn1 fibronectin 1 ISO RGD PMID:12065530 RGD:7205474 NCBI chrNW_004624765:707,872...775,056
Ensembl chrNW_004624765:707,755...775,056 		JBrowse link
G Ifnar1 interferon alpha and beta receptor subunit 1 susceptibility ISO RGD PMID:19603548 RGD:5490273 NCBI chrNW_004624745:21,545,846...21,569,719
Ensembl chrNW_004624745:21,546,007...21,572,776 		JBrowse link
G Il10 interleukin 10 ISO mRNA, protein:increased expression:lung RGD PMID:22940620 RGD:7364825 NCBI chrNW_004624807:4,687,249...4,691,658
Ensembl chrNW_004624807:4,687,176...4,691,732 		JBrowse link
G Il15 interleukin 15 ISO RGD PMID:18390740 RGD:4996474 NCBI chrNW_004624853:1,059,625...1,144,799
Ensembl chrNW_004624853:1,128,519...1,144,941 		JBrowse link
G Il1b interleukin 1 beta ISO RGD PMID:20065029 RGD:4142828 NCBI chrNW_004624749:12,852,128...12,858,478
Ensembl chrNW_004624749:12,852,021...12,858,760 		JBrowse link
G Il33 interleukin 33 ISO mRNA:increased expression:lung: RGD PMID:28401938 RGD:40400699 NCBI chrNW_004624736:10,733,944...10,786,188
Ensembl chrNW_004624736:10,764,486...10,784,864 		JBrowse link
G Nod2 nucleotide binding oligomerization domain containing 2 ISO RGD PMID:20493961 RGD:5131444 NCBI chrNW_004624757:5,956,873...6,000,052
Ensembl chrNW_004624757:5,958,486...6,000,103 		JBrowse link
G Prkn parkin RBR E3 ubiquitin protein ligase ISO protein:increased expression:lung (mouse) RGD PMID:28663335 RGD:13432209 NCBI chrNW_004624855:430,148...1,992,121
Ensembl chrNW_004624855:430,260...1,989,747 		JBrowse link
G Ptpn11 protein tyrosine phosphatase non-receptor type 11 severity ISO mRNA:increased expression:lung
associated with influenza		 RGD PMID:31782850 RGD:39131288 NCBI chrNW_004624747:19,721,581...19,813,639
Ensembl chrNW_004624747:19,721,468...19,813,670 		JBrowse link
G Ripk3 receptor interacting serine/threonine kinase 3 treatment ISO RGD PMID:25445964 RGD:127229910 NCBI chrNW_004624820:8,165,546...8,169,172 JBrowse link
G Sftpb surfactant protein B ameliorates ISO RGD PMID:20007532 RGD:151667448 NCBI chrNW_004624749:17,486,483...17,495,822
Ensembl chrNW_004624749:17,486,518...17,493,846 		JBrowse link
Streptococcus pneumonia term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Atm ATM serine/threonine kinase exacerbates ISO RGD PMID:27421701 RGD:126779562 NCBI chrNW_004624784:2,933,172...3,080,131
Ensembl chrNW_004624784:2,937,499...3,078,216 		JBrowse link
G Btk Bruton tyrosine kinase ISO RGD PMID:30873567 RGD:124715473 NCBI chrNW_004624902:1,173,101...1,216,662
Ensembl chrNW_004624902:1,182,682...1,216,171 		JBrowse link
G Ido1 indoleamine 2,3-dioxygenase 1 ISO mRNA:increased expression:lung (mouse) RGD PMID:20385761 RGD:39938865 NCBI chrNW_004624780:3,684,941...3,697,506
Ensembl chrNW_004624780:3,685,069...3,697,474 		JBrowse link
G Ifng interferon gamma ISO protein:increased expression:lung,natural killer cell (mouse) RGD PMID:21887255 RGD:40818252 NCBI chrNW_004624802:163,261...166,534
Ensembl chrNW_004624802:163,261...166,534 		JBrowse link
G Il6 interleukin 6 ISO protein:increased expression:lung,natural killer cell (mouse) RGD PMID:21887255 RGD:40818252 NCBI chrNW_004624739:7,957,709...7,963,414
Ensembl chrNW_004624739:7,957,674...7,962,318 		JBrowse link
G Irak3 interleukin 1 receptor associated kinase 3 severity ISO RGD PMID:22492852 RGD:35316076 NCBI chrNW_004624802:2,042,486...2,098,921
Ensembl chrNW_004624802:2,047,409...2,098,545 		JBrowse link
G Itgb2 integrin subunit beta 2 susceptibility ISO RGD PMID:11390487 RGD:127345090 NCBI chrNW_004624745:30,452,576...30,479,036
Ensembl chrNW_004624745:30,452,576...30,470,611 		JBrowse link
G Lamp1 lysosomal associated membrane protein 1 ISO protein:increased expression:lung, natural killer cell (mouse) RGD PMID:21887255 RGD:40818252 NCBI chrNW_004624793:661,322...675,603
Ensembl chrNW_004624793:661,342...675,675 		JBrowse link
G Marco macrophage receptor with collagenous structure exacerbates ISO RGD PMID:15263032 RGD:41412189 NCBI chrNW_004624732:26,203,345...26,236,001
Ensembl chrNW_004624732:26,203,219...26,236,057 		JBrowse link
G Pdcd1 programmed cell death 1 treatment ISO RGD PMID:25624454 RGD:40818422 NCBI chrNW_004624847:5,732,922...5,741,908
Ensembl chrNW_004624847:5,732,767...5,742,269 		JBrowse link
G Pik3cd phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit delta treatment ISO associated with immunodeficiency 14 RGD PMID:30093657 RGD:40890269 NCBI chrNW_004624818:2,751,724...2,789,145
Ensembl chrNW_004624818:2,751,724...2,779,999 		JBrowse link
G Pik3cg phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma severity ISO RGD PMID:17322108 RGD:38599154 NCBI chrNW_004624739:22,737,376...22,772,696
Ensembl chrNW_004624739:22,737,270...22,772,589 		JBrowse link
G Ripk3 receptor interacting serine/threonine kinase 3 exacerbates ISO RGD PMID:33625952 RGD:127229925 NCBI chrNW_004624820:8,165,546...8,169,172 JBrowse link
G Tnf tumor necrosis factor ISO protein:increased expression:lung,natural killer cell (mouse) RGD PMID:21887255 RGD:40818252 NCBI chrNW_004624754:24,623,059...24,625,647
Ensembl chrNW_004624754:24,623,425...24,625,531 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  disease 14229
    disease by infectious agent 1935
      Bacterial Infections and Mycoses 960
        bacterial infectious disease 722
          Bacterial Lung Diseases 125
            bacterial pneumonia + 125
            pneumonic tularemia 1
Path 2
Term Annotations click to browse term
  disease 14229
    disease of anatomical entity 13931
      respiratory system disease 4529
        lower respiratory tract disease 2024
          lung disease 1985
            Bacterial Lung Diseases 125
              bacterial pneumonia + 125
              pneumonic tularemia 1
paths to the root