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RGD DISEASE ONTOLOGY - ANNOTATIONS

RGD uses the Human Disease Ontology (DO, https://disease-ontology.org/) for disease curation across species. RGD automatically downloads each new release of the ontology on a monthly basis. Some additional terms which are required for RGD's curation purposes but are not currently covered in the official version of DO have been added. As corresponding terms are added to DO, these custom terms are retired and the DO terms substituted in existing annotations and subsequently used for curation.
Term:Bacterial Lung Diseases
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Accession:DOID:9008559 term browser browse the term
Definition:Pulmonary diseases caused by bacterial infections.
Synonyms:primary_id: RDO:9002453

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Bacterial Lung Diseases term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G CXCL8 C-X-C motif chemokine ligand 8 severity ISO protein:increased expression:nasal mucus (human) RGD PMID:24211414 RGD:40925940 NCBI chr 7:22,202,497...22,205,730
Ensembl chr 7:22,202,527...22,204,068 		JBrowse link
G MARCO macrophage receptor with collagenous structure disease_progression ISO association with Cryptococcal neoformans infection. RGD PMID:28298522 RGD:41412191 NCBI chr10:11,329,036...11,389,428
Ensembl chr10:11,329,026...11,388,999 		JBrowse link
aspiration pneumonia term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G CXCL1 C-X-C motif chemokine ligand 1 ISO RGD PMID:19515386 RGD:4891456 NCBI chr 7:22,327,041...22,329,405
Ensembl chr 7:22,569,355...22,569,900
Ensembl chr 7:22,569,355...22,569,900 		JBrowse link
G EDN1 endothelin 1 ISO protein:increased secretion:plasma (rat) RGD PMID:19262391 RGD:4145069 NCBI chr17:59,854,186...59,861,319
Ensembl chr17:59,853,699...59,861,198 		JBrowse link
G IL1A interleukin 1 alpha ISO protein:increased expression:Bronchoalveolar Lavage Fluid RGD PMID:18042282 RGD:4142854 NCBI chr14:15,789,710...15,801,938
Ensembl chr14:15,789,013...15,796,611 		JBrowse link
G NOS2 nitric oxide synthase 2 ISO CTD Direct Evidence: marker/mechanism CTD PMID:15607125 NCBI chr16:21,533,011...21,576,645
Ensembl chr16:21,533,484...21,574,257 		JBrowse link
G TNF tumor necrosis factor ISO protein:increased expression:Bronchoalveolar Lavage Fluid RGD PMID:18042282 RGD:4142854
bacterial pneumonia term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ABCC1 ATP binding cassette subfamily C member 1 (ABCC1 blood group) ISO RGD PMID:11238654 RGD:5128828 NCBI chr 5:14,972,589...15,164,594
Ensembl chr 5:14,972,646...15,164,567 		JBrowse link
G ACE2 angiotensin converting enzyme 2 ISO associated with Pseudomonas Infections;mRNA, protein:altered expression, altered activity:lung (mouse) RGD PMID:31645418 RGD:40818279 NCBI chr  X:14,032,231...14,094,163
Ensembl chr  X:14,030,233...14,077,785 		JBrowse link
G AGER advanced glycosylation end-product specific receptor severity ISO RGD PMID:21629785 RGD:6767559 NCBI chr17:39,847,343...39,851,288
Ensembl chr17:39,847,759...39,851,127 		JBrowse link
G C3 complement C3 ISO RGD PMID:16014897 RGD:5129508 NCBI chr 6:6,250,422...6,289,264 JBrowse link
G C3AR1 complement C3a receptor 1 ISO RGD PMID:16461429 RGD:5129690 NCBI chr11:8,128,192...8,135,517
Ensembl chr11:8,128,620...8,130,062 		JBrowse link
G C5 complement C5 ISO RGD PMID:17975174 RGD:5129707 NCBI chr12:18,525,855...18,624,048
Ensembl chr12:18,525,880...18,623,636 		JBrowse link
G CAT catalase ISO protein:decreased expression:lung, plasma RGD PMID:19842849 RGD:5130748 NCBI chr 1:30,792,533...30,828,920
Ensembl chr 1:30,792,399...30,829,592 		JBrowse link
G CCL19 C-C motif chemokine ligand 19 ISO mRNA, protein:increased expression:lung RGD PMID:20176793 RGD:5130918 NCBI chr12:45,928,212...45,930,897
Ensembl chr12:45,929,071...45,930,904 		JBrowse link
G CCL2 C-C motif chemokine ligand 2 ISO RGD PMID:20042590 RGD:4891443 NCBI chr16:27,763,354...27,765,437
Ensembl chr16:27,763,555...27,765,416 		JBrowse link
G CCR2 C-C motif chemokine receptor 2 ISO RGD PMID:20042590 RGD:4891443 NCBI chr22:7,795,192...7,801,242
Ensembl chr22:7,798,646...7,799,728 		JBrowse link
G CCR7 C-C motif chemokine receptor 7 ISO RGD PMID:20176793 RGD:5130918 NCBI chr16:65,620,632...65,632,394
Ensembl chr16:65,620,665...65,632,984 		JBrowse link
G CD14 CD14 molecule ISO RGD PMID:16210672 RGD:4144197 NCBI chr23:43,264,917...43,266,825
Ensembl chr23:43,264,336...43,266,993 		JBrowse link
G CD40 CD40 molecule ISO RGD PMID:20102413 RGD:5132268 NCBI chr 2:17,753,713...17,765,134
Ensembl chr 2:17,753,394...17,764,566 		JBrowse link
G CD80 CD80 molecule ISO RGD PMID:20949109 RGD:4892562 NCBI chr22:61,258,281...61,294,772 JBrowse link
G CHUK component of inhibitor of nuclear factor kappa B kinase complex ISO RGD PMID:18643924 RGD:5133701 NCBI chr 9:93,219,374...93,263,077
Ensembl chr 9:93,219,383...93,262,700 		JBrowse link
G CSF3 colony stimulating factor 3 disease_progression
treatment		 ISO associated with Peritonitis; RGD PMID:12352049 PMID:21373266 RGD:11039437 RGD:5133733 NCBI chr16:66,162,814...66,166,192
Ensembl chr16:66,163,681...66,165,172 		JBrowse link
G CSF3R colony stimulating factor 3 receptor disease_progression ISO RGD PMID:17185469 RGD:5133739 NCBI chr20:96,380,798...96,397,745
Ensembl chr20:96,384,222...96,398,618 		JBrowse link
G CXCL1 C-X-C motif chemokine ligand 1 ISO RGD PMID:11052817 PMID:21723409 RGD:5135062 RGD:5135234 NCBI chr 7:22,327,041...22,329,405
Ensembl chr 7:22,569,355...22,569,900
Ensembl chr 7:22,569,355...22,569,900 		JBrowse link
G CXCL10 C-X-C motif chemokine ligand 10 severity ISO RGD PMID:15618188 PMID:16299319 RGD:5135458 RGD:5135459 NCBI chr 7:24,526,657...24,529,193
Ensembl chr 7:24,526,680...24,529,130 		JBrowse link
G CXCL11 C-X-C motif chemokine ligand 11 ISO RGD PMID:15618188 RGD:5135459 NCBI chr 7:24,540,401...24,543,456
Ensembl chr 7:24,541,767...24,542,832 		JBrowse link
G CXCL6 C-X-C motif chemokine ligand 6 ISO RGD PMID:19846873 RGD:4145490 NCBI chr 7:22,291,949...22,294,191
Ensembl chr 7:22,292,045...22,294,207 		JBrowse link
G CXCL9 C-X-C motif chemokine ligand 9 ISO RGD PMID:15618188 RGD:5135459 NCBI chr 7:24,507,121...24,513,830
Ensembl chr 7:24,507,130...24,513,121 		JBrowse link
G CXCR3 C-X-C motif chemokine receptor 3 ISO RGD PMID:15618188 RGD:5135459 NCBI chr  X:61,430,723...61,433,777
Ensembl chr  X:61,430,725...61,433,386 		JBrowse link
G CYP2J2 cytochrome P450 family 2 subfamily J member 2 ISO protein:decreased expression:lung RGD PMID:14766666 RGD:1625385 NCBI chr20:73,083,312...73,115,174
Ensembl chr20:73,083,389...73,115,077 		JBrowse link
G FOXP3 forkhead box P3 severity ISO RGD PMID:25398094 RGD:38501102 NCBI chr  X:46,349,890...46,365,133 JBrowse link
G GP1BA glycoprotein Ib platelet subunit alpha exacerbates ISO associated with Escherichia Coli Infections RGD PMID:27845343 RGD:42722624 NCBI chr16:4,412,693...4,415,841 JBrowse link
G GRK2 G protein-coupled receptor kinase 2 ISO mRNA:decreased expression:polymorphonuclear leukocyte RGD PMID:24465168 RGD:126848796 NCBI chr 1:6,975,202...6,995,369
Ensembl chr 1:6,975,002...6,995,259 		JBrowse link
G ICAM1 intercellular adhesion molecule 1 ISO protein:increased expression:lung (mouse) RGD PMID:19846873 RGD:4145490 NCBI chr 6:9,320,991...9,338,125
Ensembl chr 6:9,322,550...9,338,263 		JBrowse link
G IFNAR1 interferon alpha and beta receptor subunit 1 severity ISO RGD PMID:19487810 RGD:5490274 NCBI chr 2:58,824,600...58,854,519
Ensembl chr 2:58,825,916...58,854,568 		JBrowse link
G IFNG interferon gamma severity ISO RGD PMID:25398094 RGD:38501102 NCBI chr11:63,785,493...63,791,071
Ensembl chr11:63,786,041...63,790,473 		JBrowse link
G IL10 interleukin 10 severity ISO RGD PMID:25398094 RGD:38501102 NCBI chr25:22,590,389...22,595,877
Ensembl chr25:22,590,962...22,594,836 		JBrowse link
G IL15 interleukin 15 ISO RGD PMID:17911627 RGD:5000754 NCBI chr 7:88,548,773...88,644,977
Ensembl chr 7:88,548,671...88,645,488 		JBrowse link
G IL17A interleukin 17A severity ISO RGD PMID:18802100 PMID:25398094 RGD:38501102 RGD:4889153 NCBI chr17:20,314,082...20,319,917
Ensembl chr17:20,315,773...20,318,785 		JBrowse link
G IL18 interleukin 18 ISO RGD PMID:17664259 RGD:4889913 NCBI chr 1:103,485,868...103,511,632
Ensembl chr 1:103,482,083...103,510,150 		JBrowse link
G IL1B interleukin 1 beta treatment
severity		 ISO associated with Agranulocytosis RGD PMID:7546648 PMID:18596024 PMID:25398094 RGD:10755357 RGD:38501102 RGD:4143205 NCBI chr14:15,844,628...15,852,652
Ensembl chr14:15,844,672...15,850,729 		JBrowse link
G IL1RL1 interleukin 1 receptor like 1 treatment ISO associated with Acinetobacter infectious disease
associated with Sepsis		 RGD PMID:20959556 PMID:29508184 RGD:40818077 RGD:5144223 NCBI chr14:5,966,551...6,020,391
Ensembl chr14:6,005,061...6,020,265 		JBrowse link
G IL1RN interleukin 1 receptor antagonist ISO RGD PMID:18322242 PMID:18596024 RGD:4143205 RGD:4143206 NCBI chr14:16,136,667...16,152,451
Ensembl chr14:16,146,333...16,151,326 		JBrowse link
G IL6 interleukin 6 severity ISO RGD PMID:25398094 RGD:38501102 NCBI chr21:35,577,513...35,582,385
Ensembl chr21:35,577,939...35,582,237 		JBrowse link
G IRAK3 interleukin 1 receptor associated kinase 3 ISO RGD PMID:20439918 PMID:28120642 RGD:34888234 RGD:36049799 NCBI chr11:61,868,817...61,920,896
Ensembl chr11:61,869,173...61,920,406 		JBrowse link
G IRF1 interferon regulatory factor 1 ISO RGD PMID:11854220 RGD:5128725 NCBI chr23:35,309,058...35,317,765
Ensembl chr23:35,307,772...35,316,763 		JBrowse link
G IRF3 interferon regulatory factor 3 ISO RGD PMID:20720199 RGD:4891951 NCBI chr 6:42,835,285...42,841,487
Ensembl chr 6:42,831,203...42,840,796 		JBrowse link
G ITGB3 integrin subunit beta 3 ISO protein:increased expression:lung, neutrophil RGD PMID:15114484 RGD:4993468 NCBI chr16:59,372,171...59,431,434
Ensembl chr16:59,374,889...59,410,857 		JBrowse link
G LEP leptin ISO RGD PMID:11937559 RGD:5128871 NCBI chr21:97,056,913...97,071,161
Ensembl chr21:97,057,529...97,071,220 		JBrowse link
G MAPK8 mitogen-activated protein kinase 8 severity ISO associated with Escherichia Coli Infections RGD PMID:22514650 RGD:150340681 NCBI chr 9:43,356,603...43,489,066
Ensembl chr 9:43,356,308...43,393,425 		JBrowse link
G MBL2 mannose binding lectin 2 ISO Legionella Pneumonia; DNA:mutations:5' utr, exon:multiple (human) RGD PMID:18641104 RGD:4889477 NCBI chr 9:78,389,534...78,394,753
Ensembl chr 9:78,389,947...78,396,079 		JBrowse link
G MMP9 matrix metallopeptidase 9 ISO protein:increased expression:bronchoalveolar lavage fluid RGD PMID:17202364 PMID:19535150 RGD:5129533 RGD:5130727 NCBI chr 2:17,867,267...17,874,757
Ensembl chr 2:17,867,177...17,874,712 		JBrowse link
G MPO myeloperoxidase ISO protein:increased activity:bronchoalveolar lavage Fluid: RGD PMID:11269653 RGD:5130992 NCBI chr16:35,120,194...35,130,851
Ensembl chr16:35,120,581...35,130,671 		JBrowse link
G NOD1 nucleotide binding oligomerization domain containing 1 ISO RGD PMID:19360122 RGD:5131449 NCBI chr21:27,907,628...27,957,621
Ensembl chr21:27,926,710...27,957,619 		JBrowse link
G NOD2 nucleotide binding oligomerization domain containing 2 ISO RGD PMID:19360122 RGD:5131449 NCBI chr 5:36,492,158...36,531,766
Ensembl chr 5:36,496,414...36,530,499 		JBrowse link
G PDPN podoplanin ISO protein:increased expression:lung RGD PMID:7864138 RGD:2292375 NCBI chr20:118,644,060...118,679,508
Ensembl chr20:118,644,051...118,679,311 		JBrowse link
G PECAM1 platelet and endothelial cell adhesion molecule 1 ISO protein:decreased expression:lung RGD PMID:12524254 RGD:724645 NCBI chr16:56,863,763...56,947,479
Ensembl chr16:56,880,934...56,950,999 		JBrowse link
G PGF placental growth factor ISO protein:increased expression:plasma RGD PMID:16702604 RGD:6483601 NCBI chr24:52,160,904...52,174,493
Ensembl chr24:52,161,787...52,173,989 		JBrowse link
G PTEN phosphatase and tensin homolog ameliorates ISO myeloid knockout RGD PMID:21527775 RGD:127285594 NCBI chr 9:81,308,058...81,412,386
Ensembl chr 9:81,309,099...81,409,146 		JBrowse link
G RIPK3 receptor interacting serine/threonine kinase 3 ameliorates ISO RGD PMID:28387756 RGD:127229944 NCBI chr24:1,318,265...1,322,610
Ensembl chr24:1,318,216...1,322,462 		JBrowse link
G RORC RAR related orphan receptor C severity ISO RGD PMID:25398094 RGD:38501102 NCBI chr20:11,854,911...11,880,221
Ensembl chr20:11,855,005...11,879,717 		JBrowse link
G SERPINE1 serpin family E member 1 severity ISO RGD PMID:17032919 RGD:4144840 NCBI chr28:12,047,520...12,060,662
Ensembl chr28:12,047,529...12,060,202 		JBrowse link
G SFTPB surfactant protein B ISO associated with Cystic Fibrosis;protein:increased expression:lung RGD PMID:12169586 PMID:15271694 RGD:4143403 RGD:4143464 NCBI chr14:21,487,424...21,497,491
Ensembl chr14:21,488,387...21,499,850 		JBrowse link
G SFTPC surfactant protein C ISO RGD PMID:12169586 PMID:18566429 RGD:4143464 RGD:4144114 NCBI chr 8:20,229,756...20,233,568
Ensembl chr 8:20,230,870...20,234,020 		JBrowse link
G SFTPD surfactant protein D ISO associated with Cystic Fibrosis;protein:decreased expression:lung
protein:increased expression:lung		 RGD PMID:12169586 PMID:15271694 RGD:4143403 RGD:4143464 NCBI chr 9:51,809,241...51,820,974
Ensembl chr 9:51,811,052...51,820,650 		JBrowse link
G STAT3 signal transducer and activator of transcription 3 ISO RGD PMID:18192501 RGD:6892945 NCBI chr16:63,877,884...63,957,894
Ensembl chr16:63,922,862...63,957,984 		JBrowse link
G TGFB1 transforming growth factor beta 1 severity ISO RGD PMID:25398094 RGD:38501102 NCBI chr 6:35,651,583...35,674,387
Ensembl chr 6:35,648,677...35,674,365 		JBrowse link
G TLR2 toll like receptor 2 ISO RGD PMID:18768871 PMID:19844782 RGD:4145337 RGD:4889533 NCBI chr 7:100,239,533...100,565,955
Ensembl chr 7:100,258,441...100,260,795 		JBrowse link
G TLR4 toll like receptor 4 ISO RGD PMID:16210672 PMID:20650991 RGD:4144172 RGD:4144197 NCBI chr12:21,873,762...21,885,562
Ensembl chr12:21,871,773...21,885,515 		JBrowse link
G TLR5 toll like receptor 5 ISO RGD PMID:19801452 RGD:5129503 NCBI chr25:6,418,895...6,440,433
Ensembl chr25:6,437,638...6,440,211 		JBrowse link
G TLR6 toll like receptor 6 ISO RGD PMID:19844782 RGD:4889533 NCBI chr27:11,439,288...11,461,580
Ensembl chr27:11,459,181...11,461,571 		JBrowse link
G TNF tumor necrosis factor severity
treatment
disease_progression		 ISO associated with Agranulocytosis RGD PMID:7546648 PMID:9310939 PMID:10650487 PMID:12958055 RGD:10449451 RGD:10450564 RGD:10755357 RGD:4143476
G TNFRSF1A TNF receptor superfamily member 1A ISO protein:increased expression:serum (mouse) RGD PMID:19842848 RGD:5131429 NCBI chr11:6,364,544...6,378,880
Ensembl chr11:6,364,330...6,378,902 		JBrowse link
G TNFRSF1B TNF receptor superfamily member 1B ISO protein:increased expression:serum (mouse) RGD PMID:19842848 RGD:5131429 NCBI chr20:119,590,621...119,633,562
Ensembl chr20:119,590,325...119,633,497 		JBrowse link
G TREM1 triggering receptor expressed on myeloid cells 1 severity
ameliorates		 ISO RGD PMID:16960786 PMID:22996209 PMID:24465168 RGD:126848796 RGD:126925987 RGD:127229902 NCBI chr17:30,873,647...30,885,292
Ensembl chr17:30,873,666...30,886,967 		JBrowse link
G ZC3H12A zinc finger CCCH-type containing 12A ISO associated with Pseudomonas Infections RGD PMID:29695841 RGD:39938967 NCBI chr20:95,388,469...95,398,305
Ensembl chr20:95,388,477...95,397,960 		JBrowse link
Chlamydia pneumonia term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G CD274 CD274 molecule ISO mRNA:increased expression:lung RGD PMID:26378990 RGD:41412180 NCBI chr12:74,038,844...74,060,662
Ensembl chr12:74,041,767...74,056,806 		JBrowse link
G PDCD1 programmed cell death 1 ISO mRNA:increased expression:lung RGD PMID:26378990 RGD:41412180 NCBI chr10:127,877,383...127,886,234
Ensembl chr10:127,878,554...127,886,088 		JBrowse link
G PIK3CD phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit delta severity ISO RGD PMID:29893841 RGD:40890270 NCBI chr20:122,040,131...122,111,397
Ensembl chr20:122,041,963...122,078,504 		JBrowse link
Klebsiella pneumonia term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G CXCL8 C-X-C motif chemokine ligand 8 ISO RGD PMID:11207292 RGD:38549344 NCBI chr 7:22,202,497...22,205,730
Ensembl chr 7:22,202,527...22,204,068 		JBrowse link
G IL23A interleukin 23 subunit alpha severity ISO RGD PMID:16157683 RGD:39457940 NCBI chr11:52,289,486...52,296,735
Ensembl chr11:52,295,106...52,297,244 		JBrowse link
G IRAK3 interleukin 1 receptor associated kinase 3 severity ISO mRNA:increased expression:lung (mouse) RGD PMID:20864681 PMID:22729155 RGD:35316077 RGD:36049798 NCBI chr11:61,868,817...61,920,896
Ensembl chr11:61,869,173...61,920,406 		JBrowse link
G LCN2 lipocalin 2 ameliorates
exacerbates		 ISO protein:increased expression:serum
protein:increased expression:lung		 RGD PMID:19342674 PMID:25234944 PMID:29633303 RGD:126725082 RGD:126725084 RGD:126725085 NCBI chr12:9,976,278...9,981,087
Ensembl chr12:9,976,614...9,980,870 		JBrowse link
G PLAC8 placenta associated 8 severity ISO RGD PMID:17404296 RGD:40924563 NCBI chr 7:31,471,166...31,496,053
Ensembl chr 7:31,470,774...31,489,432 		JBrowse link
G TREM1 triggering receptor expressed on myeloid cells 1 disease_progression ISO RGD PMID:24396044 RGD:126925976 NCBI chr17:30,873,647...30,885,292
Ensembl chr17:30,873,666...30,886,967 		JBrowse link
Legionnaires' disease term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ADA adenosine deaminase ISO protein:increased expression:serum RGD PMID:9255891 RGD:5128857 NCBI chr 2:19,167,209...19,200,233 JBrowse link
G CXCL1 C-X-C motif chemokine ligand 1 ISO mRNA, protein:increased expression:lung RGD PMID:11254553 RGD:5135252 NCBI chr 7:22,327,041...22,329,405
Ensembl chr 7:22,569,355...22,569,900
Ensembl chr 7:22,569,355...22,569,900 		JBrowse link
G CXCL6 C-X-C motif chemokine ligand 6 ISO mRNA, protein:increased expression:lung RGD PMID:11254553 RGD:5135252 NCBI chr 7:22,291,949...22,294,191
Ensembl chr 7:22,292,045...22,294,207 		JBrowse link
G IFNG interferon gamma ISO CTD Direct Evidence: therapeutic CTD PMID:11349020 NCBI chr11:63,785,493...63,791,071
Ensembl chr11:63,786,041...63,790,473 		JBrowse link
G IL18 interleukin 18 ISO RGD PMID:11083766 RGD:4889865 NCBI chr 1:103,485,868...103,511,632
Ensembl chr 1:103,482,083...103,510,150 		JBrowse link
G LOC103217855 C-X-C chemokine receptor type 2 ISO RGD PMID:11254553 RGD:5135252 NCBI chr10:104,012,906...104,025,599
Ensembl chr10:104,022,811...104,023,893 		JBrowse link
G LOC103233058 fractalkine ISO RGD PMID:16113250 RGD:4891897 NCBI chr 5:43,310,711...43,323,533
Ensembl chr 5:43,310,753...43,323,529 		JBrowse link
G MBL2 mannose binding lectin 2 susceptibility ISO RGD PMID:19073229 RGD:12910934 NCBI chr 9:78,389,534...78,394,753
Ensembl chr 9:78,389,947...78,396,079 		JBrowse link
G NOD1 nucleotide binding oligomerization domain containing 1 ISO RGD PMID:20685341 RGD:5131443 NCBI chr21:27,907,628...27,957,621
Ensembl chr21:27,926,710...27,957,619 		JBrowse link
G NOD2 nucleotide binding oligomerization domain containing 2 ISO RGD PMID:20685341 RGD:5131443 NCBI chr 5:36,492,158...36,531,766
Ensembl chr 5:36,496,414...36,530,499 		JBrowse link
G TLR5 toll like receptor 5 susceptibility ISO ClinVar Annotator: match by term: Legionnaire disease, susceptibility to ClinVar
OMIM		 PMID:14623910 PMID:16027372 PMID:23447684 NCBI chr25:6,418,895...6,440,433
Ensembl chr25:6,437,638...6,440,211 		JBrowse link
G TNFRSF1A TNF receptor superfamily member 1A ISO RGD PMID:18838275 RGD:5131445 NCBI chr11:6,364,544...6,378,880
Ensembl chr11:6,364,330...6,378,902 		JBrowse link
G TNFRSF1B TNF receptor superfamily member 1B ISO RGD PMID:18838275 RGD:5131445 NCBI chr20:119,590,621...119,633,562
Ensembl chr20:119,590,325...119,633,497 		JBrowse link
Mycoplasma pneumoniae pneumonia term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ADA adenosine deaminase ISO protein:increased expression:serum RGD PMID:9255891 RGD:5128857 NCBI chr 2:19,167,209...19,200,233 JBrowse link
G ATP1B2 ATPase Na+/K+ transporting subunit beta 2 severity ISO RGD PMID:28302172 RGD:32716376 NCBI chr16:7,030,016...7,035,620
Ensembl chr16:7,030,055...7,037,754 		JBrowse link
G CCL5 C-C motif chemokine ligand 5 ISO protein:increased secretion:lung, secretion (mouse) RGD PMID:18717637 RGD:4891914 NCBI chr16:29,351,214...29,361,317 JBrowse link
G CCL8 C-C motif chemokine ligand 8 ISO RGD PMID:16988274 RGD:4892091 NCBI chr16:27,821,149...27,823,919
Ensembl chr16:27,821,970...27,823,528 		JBrowse link
G CCR5 C-C motif chemokine receptor 5 ISO protein:increased expression:lung, T-helper cell (mouse) RGD PMID:16988274 RGD:4892091 NCBI chr22:7,803,794...7,818,112 JBrowse link
G CLEC5A C-type lectin domain containing 5A severity ISO RGD PMID:28302172 RGD:32716376 NCBI chr21:110,629,443...110,650,350
Ensembl chr21:110,632,181...110,649,204 		JBrowse link
G COL3A1 collagen type III alpha 1 chain severity ISO RGD PMID:28302172 RGD:32716376 NCBI chr10:74,455,133...74,493,392 JBrowse link
G COL6A1 collagen type VI alpha 1 chain severity ISO RGD PMID:28302172 RGD:32716376 NCBI chr 2:89,608,525...89,649,823 JBrowse link
G COL6A2 collagen type VI alpha 2 chain severity ISO RGD PMID:28302172 RGD:32716376 NCBI chr 2:89,724,355...89,758,389
Ensembl chr 2:89,737,003...89,758,425 		JBrowse link
G CRP C-reactive protein ISO RGD PMID:21426633 RGD:5131292 NCBI chr20:4,232,262...4,235,826
Ensembl chr20:4,232,913...4,235,377 		JBrowse link
G DNASE1L3 deoxyribonuclease 1L3 severity ISO RGD PMID:28302172 RGD:32716376 NCBI chr22:19,487,767...19,496,019
Ensembl chr22:19,487,596...19,496,129 		JBrowse link
G FCER2 Fc fragment of IgE receptor II severity ISO RGD PMID:28302172 RGD:32716376 NCBI chr 6:7,175,032...7,189,002
Ensembl chr 6:7,175,032...7,189,057 		JBrowse link
G FLT1 fms related receptor tyrosine kinase 1 severity ISO RGD PMID:28302172 RGD:32716376 NCBI chr 3:7,412,506...7,608,122
Ensembl chr 3:7,412,172...7,607,967 		JBrowse link
G GALC galactosylceramidase ISO protein:increased expression:serum (mouse)
associated with Guillain-Barre syndrome; protein:increased expression:Cerebrospinal fluid, serum (human)
associated with Guillain-Barre syndrome; protein:increased expression:serum (human)		 RGD PMID:12225900 PMID:27490360 PMID:29301655 PMID:30396892 RGD:38599168 RGD:38599169 RGD:38599171 RGD:38599172 NCBI chr24:65,556,763...65,621,693
Ensembl chr24:65,558,074...65,621,258 		JBrowse link
G HDC histidine decarboxylase ISO RGD PMID:17158962 RGD:5143920 NCBI chr26:33,051,048...33,074,872
Ensembl chr26:33,051,966...33,074,563 		JBrowse link
G HTRA3 HtrA serine peptidase 3 severity ISO RGD PMID:28302172 RGD:32716376 NCBI chr27:44,214,635...44,252,673
Ensembl chr27:44,214,874...44,252,732 		JBrowse link
G IFNG interferon gamma ISO mRNA:increased expression:lung: RGD PMID:7935058 RGD:10755754 NCBI chr11:63,785,493...63,791,071
Ensembl chr11:63,786,041...63,790,473 		JBrowse link
G IL13 interleukin 13 ISO protein:increased expression:serum RGD PMID:20416219 RGD:4145765 NCBI chr23:35,475,762...35,479,419
Ensembl chr23:35,476,490...35,478,869 		JBrowse link
G IL22RA2 interleukin 22 receptor subunit alpha 2 severity ISO RGD PMID:28302172 RGD:32716376 NCBI chr13:36,254,113...36,273,279
Ensembl chr13:36,255,116...36,271,258 		JBrowse link
G INHBA inhibin subunit beta A severity ISO RGD PMID:28302172 RGD:32716376 NCBI chr21:16,936,054...16,951,430
Ensembl chr21:16,936,175...16,946,880 		JBrowse link
G KLRF1 killer cell lectin like receptor F1 severity ISO RGD PMID:28302172 RGD:32716376 NCBI chr11:9,715,900...9,731,454
Ensembl chr11:9,716,010...9,731,387 		JBrowse link
G MS4A1 membrane spanning 4-domains A1 severity ISO RGD PMID:28302172 RGD:32716376 NCBI chr 1:13,343,647...13,358,639
Ensembl chr 1:13,345,253...13,358,547 		JBrowse link
G PLD4 phospholipase D family member 4 severity ISO RGD PMID:28302172 RGD:32716376 NCBI chr24:82,848,775...82,857,359
Ensembl chr24:82,851,238...82,857,579 		JBrowse link
G TCF7 transcription factor 7 severity ISO RGD PMID:28302172 RGD:32716376 NCBI chr23:36,919,648...36,953,088
Ensembl chr23:36,919,745...36,951,192 		JBrowse link
G TCL1A TCL1 family AKT coactivator A severity ISO RGD PMID:28302172 RGD:32716376 NCBI chr24:73,556,188...73,570,376
Ensembl chr24:73,566,270...73,570,348 		JBrowse link
G TNF tumor necrosis factor ISO protein:increased expression:serum RGD PMID:20416219 RGD:4145765
G TNFRSF13C TNF receptor superfamily member 13C severity ISO RGD PMID:28302172 RGD:32716376 NCBI chr19:24,457,381...24,459,438 JBrowse link
Pneumococcal Pneumonia term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G AICDA activation induced cytidine deaminase ISO RGD PMID:26456931 RGD:11098923 NCBI chr11:8,426,920...8,438,331
Ensembl chr11:8,428,922...8,431,641 		JBrowse link
G ALOX5 arachidonate 5-lipoxygenase ISO RGD PMID:20231413 RGD:4890435 NCBI chr 9:41,085,257...41,145,760
Ensembl chr 9:41,085,361...41,145,331 		JBrowse link
G BTK Bruton tyrosine kinase ameliorates ISO RGD PMID:30646846 RGD:124715470 NCBI chr  X:89,690,569...89,727,420 JBrowse link
G C3 complement C3 disease_progression ISO protein:decreased expression:serum
associated with Liver Cirrhosis, Experimental;protein:decreased expression:respiratory system fluid/secretion		 RGD PMID:20405 PMID:15972516 PMID:17956621 RGD:5129509 RGD:5129523 RGD:5130163 NCBI chr 6:6,250,422...6,289,264 JBrowse link
G C5 complement C5 severity ISO RGD PMID:7814608 RGD:5130159 NCBI chr12:18,525,855...18,624,048
Ensembl chr12:18,525,880...18,623,636 		JBrowse link
G CCL5 C-C motif chemokine ligand 5 susceptibility ISO RGD PMID:16455992 RGD:4892130 NCBI chr16:29,351,214...29,361,317 JBrowse link
G CD14 CD14 molecule ISO RGD PMID:17185649 RGD:4144788 NCBI chr23:43,264,917...43,266,825
Ensembl chr23:43,264,336...43,266,993 		JBrowse link
G CHI3L1 chitinase 3 like 1 ISO protein:increased secretion:serum (human) RGD PMID:10515841 RGD:4892626 NCBI chr25:26,160,993...26,169,005
Ensembl chr25:26,160,961...26,169,566 		JBrowse link
G CRHR2 corticotropin releasing hormone receptor 2 ISO RGD PMID:21774994 RGD:5147472 NCBI chr21:27,703,637...27,738,873
Ensembl chr21:27,708,113...27,739,116 		JBrowse link
G CRP C-reactive protein disease_progression ISO RGD PMID:21281676 RGD:5131293 NCBI chr20:4,232,262...4,235,826
Ensembl chr20:4,232,913...4,235,377 		JBrowse link
G CXCL1 C-X-C motif chemokine ligand 1 ISO protein:increased expression:respiratory system fluid/secretion RGD PMID:20958976 RGD:5134957 NCBI chr 7:22,327,041...22,329,405
Ensembl chr 7:22,569,355...22,569,900
Ensembl chr 7:22,569,355...22,569,900 		JBrowse link
G CXCL8 C-X-C motif chemokine ligand 8 ISO CTD Direct Evidence: marker/mechanism CTD PMID:24894820 NCBI chr 7:22,202,497...22,205,730
Ensembl chr 7:22,202,527...22,204,068 		JBrowse link
G CXCL9 C-X-C motif chemokine ligand 9 ISO protein:increased expression:lung RGD PMID:20381636 RGD:5135285 NCBI chr 7:24,507,121...24,513,830
Ensembl chr 7:24,507,130...24,513,121 		JBrowse link
G HMOX1 heme oxygenase 1 ISO associated with influenza;protein:increased expression:lung RGD PMID:17348295 RGD:4145366 NCBI chr19:18,144,466...18,157,944
Ensembl chr19:18,144,545...18,157,971 		JBrowse link
G IL15 interleukin 15 ISO protein:increased expression:alveolar macrophage, bronchial epithelial cell RGD PMID:17611121 RGD:5000755 NCBI chr 7:88,548,773...88,644,977
Ensembl chr 7:88,548,671...88,645,488 		JBrowse link
G IL15RA interleukin 15 receptor subunit alpha ISO RGD PMID:17611121 RGD:5000755 NCBI chr 9:6,061,475...6,096,370
Ensembl chr 9:6,061,197...6,096,250 		JBrowse link
G IL17A interleukin 17A ISO RGD PMID:19995896 RGD:4888531 NCBI chr17:20,314,082...20,319,917
Ensembl chr17:20,315,773...20,318,785 		JBrowse link
G IL18 interleukin 18 ISO RGD PMID:15770015 RGD:4889960 NCBI chr 1:103,485,868...103,511,632
Ensembl chr 1:103,482,083...103,510,150 		JBrowse link
G IL6 interleukin 6 ISO RGD PMID:20643849 RGD:4143255 NCBI chr21:35,577,513...35,582,385
Ensembl chr21:35,577,939...35,582,237 		JBrowse link
G LEP leptin ISO RGD PMID:17822444 RGD:5128869 NCBI chr21:97,056,913...97,071,161
Ensembl chr21:97,057,529...97,071,220 		JBrowse link
G LEPR leptin receptor ISO RGD PMID:21148797 RGD:5128846 NCBI chr20:67,454,205...67,567,524
Ensembl chr20:67,454,334...67,524,229 		JBrowse link
G LOC103243260 corticotropin-releasing factor receptor 1 ISO RGD PMID:21774994 RGD:5147472 NCBI chr16:60,070,156...60,120,857
Ensembl chr16:60,070,066...60,120,712 		JBrowse link
G MAPK1 mitogen-activated protein kinase 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:24894820 NCBI chr19:4,246,144...4,352,648
Ensembl chr19:4,246,122...4,353,325 		JBrowse link
G MAPK3 mitogen-activated protein kinase 3 ISO CTD Direct Evidence: marker/mechanism CTD PMID:24894820 NCBI chr 5:26,536,471...26,545,666
Ensembl chr 5:26,536,532...26,546,461 		JBrowse link
G MASP2 MBL associated serine protease 2 ISO CTD Direct Evidence: marker/mechanism CTD PMID:12904520 NCBI chr20:120,731,591...120,753,104 JBrowse link
G MBL2 mannose binding lectin 2 no_association ISO DNA:mutations:5' utr, exon:multiple (human)
DNA:polymorphisms:5' utr, exon:multiple (human)		 RGD PMID:12047967 PMID:18641104 RGD:4889477 RGD:4889478 NCBI chr 9:78,389,534...78,394,753
Ensembl chr 9:78,389,947...78,396,079 		JBrowse link
G NOS2 nitric oxide synthase 2 ISO RGD PMID:17056580 RGD:4891950 NCBI chr16:21,533,011...21,576,645
Ensembl chr16:21,533,484...21,574,257 		JBrowse link
G PTEN phosphatase and tensin homolog ameliorates ISO myeloid knockout RGD PMID:20505137 RGD:127285597 NCBI chr 9:81,308,058...81,412,386
Ensembl chr 9:81,309,099...81,409,146 		JBrowse link
G SFTPD surfactant protein D severity ISO RGD PMID:16255775 RGD:4143519 NCBI chr 9:51,809,241...51,820,974
Ensembl chr 9:51,811,052...51,820,650 		JBrowse link
G SIRT1 sirtuin 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:24894820 NCBI chr 9:63,463,059...63,497,893
Ensembl chr 9:63,462,389...63,497,867 		JBrowse link
G STING1 stimulator of interferon response cGAMP interactor 1 ISO RGD PMID:29263110 RGD:39128230 NCBI chr23:42,153,576...42,160,903
Ensembl chr23:42,153,026...42,160,907 		JBrowse link
G TLR2 toll like receptor 2 ISO RGD PMID:19956717 RGD:4145321 NCBI chr 7:100,239,533...100,565,955
Ensembl chr 7:100,258,441...100,260,795 		JBrowse link
G TNF tumor necrosis factor ISO associated with influenza;protein:increased expression:lung RGD PMID:9032201 PMID:17348295 RGD:4143479 RGD:4145366
G TREM1 triggering receptor expressed on myeloid cells 1 ameliorates ISO RGD PMID:19596984 PMID:24752755 RGD:126928121 RGD:127229903 NCBI chr17:30,873,647...30,885,292
Ensembl chr17:30,873,666...30,886,967 		JBrowse link
pneumonic tularemia term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G IDO1 indoleamine 2,3-dioxygenase 1 ISO RGD PMID:20385761 RGD:39938865 NCBI chr 8:37,930,910...37,950,790
Ensembl chr 8:37,930,562...37,946,505 		JBrowse link
Staphylococcal Pneumonia term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G AKT1 AKT serine/threonine kinase 1 treatment ISO RGD PMID:23613163 RGD:38676477 NCBI chr24:82,704,087...82,730,711
Ensembl chr24:82,704,068...82,727,698 		JBrowse link
G CD86 CD86 molecule ISO protein:decreased expression:spleen, plasmacytoid dendritic cell (mouse) RGD PMID:20949109 RGD:4892562 NCBI chr22:58,741,534...58,805,417
Ensembl chr22:58,741,525...58,805,366 		JBrowse link
G CFTR CF transmembrane conductance regulator ISO RGD PMID:28289144 RGD:36049750 NCBI chr21:86,154,313...86,332,436 JBrowse link
G CSF3 colony stimulating factor 3 treatment ISO RGD PMID:10228098 RGD:11039478 NCBI chr16:66,162,814...66,166,192
Ensembl chr16:66,163,681...66,165,172 		JBrowse link
G FN1 fibronectin 1 ISO RGD PMID:12065530 RGD:7205474 NCBI chr10:101,177,867...101,254,613
Ensembl chr10:101,176,789...101,254,633 		JBrowse link
G IFNAR1 interferon alpha and beta receptor subunit 1 susceptibility ISO RGD PMID:19603548 RGD:5490273 NCBI chr 2:58,824,600...58,854,519
Ensembl chr 2:58,825,916...58,854,568 		JBrowse link
G IL10 interleukin 10 ISO mRNA, protein:increased expression:lung RGD PMID:22940620 RGD:7364825 NCBI chr25:22,590,389...22,595,877
Ensembl chr25:22,590,962...22,594,836 		JBrowse link
G IL15 interleukin 15 ISO RGD PMID:18390740 RGD:4996474 NCBI chr 7:88,548,773...88,644,977
Ensembl chr 7:88,548,671...88,645,488 		JBrowse link
G IL1B interleukin 1 beta ISO RGD PMID:20065029 RGD:4142828 NCBI chr14:15,844,628...15,852,652
Ensembl chr14:15,844,672...15,850,729 		JBrowse link
G IL33 interleukin 33 ISO mRNA:increased expression:lung: RGD PMID:28401938 RGD:40400699 NCBI chr12:73,235,585...73,283,665
Ensembl chr12:73,237,406...73,252,436 		JBrowse link
G NOD2 nucleotide binding oligomerization domain containing 2 ISO RGD PMID:20493961 RGD:5131444 NCBI chr 5:36,492,158...36,531,766
Ensembl chr 5:36,496,414...36,530,499 		JBrowse link
G PRKN parkin RBR E3 ubiquitin protein ligase ISO protein:increased expression:lung (mouse) RGD PMID:28663335 RGD:13432209 NCBI chr13:88,856,056...90,329,379 JBrowse link
G PTPN11 protein tyrosine phosphatase non-receptor type 11 severity ISO mRNA:increased expression:lung
associated with influenza		 RGD PMID:31782850 RGD:39131288 NCBI chr11:107,658,495...107,754,457
Ensembl chr11:107,658,453...107,752,637 		JBrowse link
G RIPK3 receptor interacting serine/threonine kinase 3 treatment ISO RGD PMID:25445964 RGD:127229910 NCBI chr24:1,318,265...1,322,610
Ensembl chr24:1,318,216...1,322,462 		JBrowse link
G SFTPB surfactant protein B ameliorates ISO RGD PMID:20007532 RGD:151667448 NCBI chr14:21,487,424...21,497,491
Ensembl chr14:21,488,387...21,499,850 		JBrowse link
Streptococcus pneumonia term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ATM ATM serine/threonine kinase exacerbates ISO RGD PMID:27421701 RGD:126779562 NCBI chr 1:99,653,208...99,786,889
Ensembl chr 1:99,653,139...99,791,520 		JBrowse link
G BTK Bruton tyrosine kinase ISO RGD PMID:30873567 RGD:124715473 NCBI chr  X:89,690,569...89,727,420 JBrowse link
G IDO1 indoleamine 2,3-dioxygenase 1 ISO mRNA:increased expression:lung (mouse) RGD PMID:20385761 RGD:39938865 NCBI chr 8:37,930,910...37,950,790
Ensembl chr 8:37,930,562...37,946,505 		JBrowse link
G IFNG interferon gamma ISO protein:increased expression:lung,natural killer cell (mouse) RGD PMID:21887255 RGD:40818252 NCBI chr11:63,785,493...63,791,071
Ensembl chr11:63,786,041...63,790,473 		JBrowse link
G IL6 interleukin 6 ISO protein:increased expression:lung,natural killer cell (mouse) RGD PMID:21887255 RGD:40818252 NCBI chr21:35,577,513...35,582,385
Ensembl chr21:35,577,939...35,582,237 		JBrowse link
G IRAK3 interleukin 1 receptor associated kinase 3 severity ISO RGD PMID:22492852 RGD:35316076 NCBI chr11:61,868,817...61,920,896
Ensembl chr11:61,869,173...61,920,406 		JBrowse link
G ITGB2 integrin subunit beta 2 susceptibility ISO RGD PMID:11390487 RGD:127345090 NCBI chr 2:88,597,554...88,644,890
Ensembl chr 2:88,597,556...88,624,025 		JBrowse link
G LAMP1 lysosomal associated membrane protein 1 ISO protein:increased expression:lung, natural killer cell (mouse) RGD PMID:21887255 RGD:40818252 NCBI chr 3:91,295,758...91,319,881
Ensembl chr 3:91,295,681...91,321,333 		JBrowse link
G MARCO macrophage receptor with collagenous structure exacerbates ISO RGD PMID:15263032 RGD:41412189 NCBI chr10:11,329,036...11,389,428
Ensembl chr10:11,329,026...11,388,999 		JBrowse link
G NCR1 natural cytotoxicity triggering receptor 1 severity ISO RGD PMID:21887255 RGD:40818252 NCBI chr 6:47,521,488...47,527,713
Ensembl chr 6:47,521,956...47,530,961 		JBrowse link
G PDCD1 programmed cell death 1 treatment ISO RGD PMID:25624454 RGD:40818422 NCBI chr10:127,877,383...127,886,234
Ensembl chr10:127,878,554...127,886,088 		JBrowse link
G PIK3CD phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit delta treatment ISO associated with immunodeficiency 14 RGD PMID:30093657 RGD:40890269 NCBI chr20:122,040,131...122,111,397
Ensembl chr20:122,041,963...122,078,504 		JBrowse link
G PIK3CG phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma severity ISO RGD PMID:17322108 RGD:38599154 NCBI chr21:75,781,812...75,823,404
Ensembl chr21:75,784,648...75,825,496 		JBrowse link
G RIPK3 receptor interacting serine/threonine kinase 3 exacerbates ISO RGD PMID:33625952 RGD:127229925 NCBI chr24:1,318,265...1,322,610
Ensembl chr24:1,318,216...1,322,462 		JBrowse link
G TNF tumor necrosis factor ISO protein:increased expression:lung,natural killer cell (mouse) RGD PMID:21887255 RGD:40818252
Term paths to the root
Path 1
Term Annotations click to browse term
  disease 15416
    disease by infectious agent 2092
      Bacterial Infections and Mycoses 1023
        bacterial infectious disease 785
          Bacterial Lung Diseases 135
            bacterial pneumonia + 135
            pneumonic tularemia 1
Path 2
Term Annotations click to browse term
  disease 15416
    disease of anatomical entity 15079
      respiratory system disease 4788
        lower respiratory tract disease 2147
          lung disease 2107
            Bacterial Lung Diseases 135
              bacterial pneumonia + 135
              pneumonic tularemia 1
paths to the root