RGD DISEASE ONTOLOGY - ANNOTATIONS
RGD uses the Human Disease Ontology (DO, https://disease-ontology.org/) for disease curation across species. RGD automatically downloads each new release of the ontology on a monthly basis. Some additional terms which are required for RGD's curation purposes but are not currently covered in the official version of DO have been added. As corresponding terms are added to DO, these custom terms are retired and the DO terms substituted in existing annotations and subsequently used for curation.
Term: Bacterial Lung Diseases
Accession: DOID:9008559
browse the term
Definition: Pulmonary diseases caused by bacterial infections.
Synonyms: primary_id: RDO:9002453
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CXCL8
C-X-C motif chemokine ligand 8
severity
ISO
protein:increased expression:nasal mucus (human)
RGD
PMID:24211414
RGD:40925940
NCBI chr 4:50,452,857...50,456,015
Ensembl chr 4:56,286,708...56,288,083
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MARCO
macrophage receptor with collagenous structure
disease_progression
ISO
association with Cryptococcal neoformans infection.
RGD
PMID:28298522
RGD:41412191
NCBI chr2B:5,896,433...5,940,284
Ensembl chr2B:119,475,677...119,520,385
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ACE
angiotensin I converting enzyme
ISO
associated with Cerebrovascular Accident
RGD
PMID:14990394
RGD:4140926
NCBI chr17:57,556,294...57,577,294
Ensembl chr17:62,702,341...62,733,853
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EDN1
endothelin 1
ISO
protein:increased secretion:plasma (rat)
RGD
PMID:19262391
RGD:4145069
NCBI chr 6:12,076,312...12,142,861
Ensembl chr 6:12,462,718...12,503,545
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IL1A
interleukin 1 alpha
ISO
protein:increased expression:Bronchoalveolar Lavage Fluid
RGD
PMID:18042282
RGD:4142854
NCBI chr2A:89,273,482...89,284,421
Ensembl chr2A:113,784,854...113,795,801
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LOC100974886
uncharacterized LOC100974886
ISO
RGD
PMID:19515386
RGD:4891456
NCBI chr 4:50,092,989...50,095,541
Ensembl chr 4:55,925,562...55,986,555
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LOC100976904
growth-regulated alpha protein
ISO
RGD
PMID:19515386
RGD:4891456
NCBI chr 4:50,325,248...50,327,165
Ensembl chr 4:56,153,899...56,159,474
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NOS2
nitric oxide synthase 2
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:15607125
NCBI chr17:28,984,295...29,021,516
Ensembl chr17:29,471,510...29,617,093
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TNF
tumor necrosis factor
ISO
protein:increased expression:Bronchoalveolar Lavage Fluid
RGD
PMID:18042282
RGD:4142854
NCBI chr 6:31,236,650...31,239,423
Ensembl chr 6:32,126,618...32,129,381
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ABCC1
ATP binding cassette subfamily C member 1 (ABCC1 blood group)
ISO
RGD
PMID:11238654
RGD:5128828
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ACE2
angiotensin converting enzyme 2
ISO
associated with Pseudomonas Infections;mRNA, protein:altered expression, altered activity:lung (mouse)
RGD
PMID:31645418
RGD:40818279
NCBI chr X:8,189,267...8,229,415
Ensembl chr X:15,470,896...15,510,891
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AGER
advanced glycosylation end-product specific receptor
severity
ISO
RGD
PMID:21629785
RGD:6767559
NCBI chr 6:31,828,363...31,831,981
Ensembl chr 6:32,708,251...32,711,641
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C3
complement C3
ISO
RGD
PMID:16014897
RGD:5129508
NCBI chr19:5,708,211...5,753,178
Ensembl chr19:6,629,287...6,674,699
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C3AR1
complement C3a receptor 1
ISO
RGD
PMID:16461429
RGD:5129690
NCBI chr12:8,178,064...8,186,206
Ensembl chr12:8,220,933...8,222,381
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C5
complement C5
ISO
RGD
PMID:17975174
RGD:5129707
NCBI chr 9:92,069,574...92,202,513
Ensembl chr 9:120,426,354...120,523,856
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CAT
catalase
ISO
protein:decreased expression:lung, plasma
RGD
PMID:19842849
RGD:5130748
NCBI chr11:34,413,253...34,446,831
Ensembl chr11:34,289,603...34,323,160
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CCL19
C-C motif chemokine ligand 19
ISO
mRNA, protein:increased expression:lung
RGD
PMID:20176793
RGD:5130918
NCBI chr 9:34,525,820...34,527,628
Ensembl chr 9:35,334,353...35,336,108
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CCL2
C-C motif chemokine ligand 2
ISO
RGD
PMID:20042590
RGD:4891443
NCBI chr17:22,528,154...22,530,091
Ensembl chr17:22,820,890...22,823,384
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CCR2
C-C motif chemokine receptor 2
ISO
RGD
PMID:20042590
RGD:4891443
NCBI chr 3:46,255,725...46,263,285
Ensembl chr 3:47,361,124...47,368,312
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CCR7
C-C motif chemokine receptor 7
ISO
RGD
PMID:20176793
RGD:5130918
NCBI chr17:16,720,236...16,731,955
Ensembl chr17:16,949,119...16,956,370
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CD14
CD14 molecule
ISO
RGD
PMID:16210672
RGD:4144197
NCBI chr 5:135,996,265...135,997,909
Ensembl chr 5:142,113,082...142,118,966
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CD40
CD40 molecule
ISO
RGD
PMID:20102413
RGD:5132268
NCBI chr20:42,455,711...42,467,139
Ensembl chr20:43,541,619...43,552,994
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CD80
CD80 molecule
ISO
RGD
PMID:20949109
RGD:4892562
NCBI chr 3:116,646,590...116,683,725
Ensembl chr 3:123,559,559...123,594,870
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CHUK
component of inhibitor of nuclear factor kappa B kinase complex
ISO
RGD
PMID:18643924
RGD:5133701
NCBI chr10:96,794,228...96,835,449
Ensembl chr10:100,280,490...100,316,918
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CSF3
colony stimulating factor 3
disease_progression treatment
ISO
associated with Peritonitis;
RGD
PMID:12352049 PMID:21373266
RGD:11039437 RGD:5133733
NCBI chr17:17,271,074...17,273,493
Ensembl chr17:17,491,276...17,493,729
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CSF3R
colony stimulating factor 3 receptor
disease_progression
ISO
RGD
PMID:17185469
RGD:5133739
NCBI chr 1:35,730,678...35,747,939
Ensembl chr 1:36,897,153...36,910,612
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CXCL10
C-X-C motif chemokine ligand 10
severity
ISO
RGD
PMID:15618188 PMID:16299319
RGD:5135458 RGD:5135459
NCBI chr 4:48,182,355...48,184,733
Ensembl chr 4:54,020,204...54,022,606
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CXCL11
C-X-C motif chemokine ligand 11
ISO
RGD
PMID:15618188
RGD:5135459
NCBI chr 4:48,169,954...48,172,455
Ensembl chr 4:54,007,818...54,010,336
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CXCL6
C-X-C motif chemokine ligand 6
ISO
RGD
PMID:19846873
RGD:4145490
NCBI chr 4:50,357,643...50,359,822
Ensembl chr 4:56,189,961...56,192,402
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CXCL9
C-X-C motif chemokine ligand 9
ISO
RGD
PMID:15618188
RGD:5135459
NCBI chr 4:48,198,478...48,204,658
Ensembl chr 4:54,036,342...54,042,502
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CXCR3
C-X-C motif chemokine receptor 3
ISO
RGD
PMID:15618188
RGD:5135459
NCBI chr X:60,880,759...60,883,355
Ensembl chr X:70,933,160...70,935,756
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CYP2J2
cytochrome P450 family 2 subfamily J member 2
ISO
protein:decreased expression:lung
RGD
PMID:14766666
RGD:1625385
NCBI chr 1:59,151,079...59,184,625
Ensembl chr 1:60,856,269...60,889,810
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F2
coagulation factor II, thrombin
ISO
protein:increased expression:lung
RGD
PMID:21897338
RGD:6893486
NCBI chr11:46,669,925...46,690,391
Ensembl chr11:47,227,891...47,249,157
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FOXP3
forkhead box P3
severity
ISO
RGD
PMID:25398094
RGD:38501102
NCBI chr X:41,550,462...41,567,492
Ensembl chr X:49,402,652...49,417,029
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GP1BA
glycoprotein Ib platelet subunit alpha
exacerbates
ISO
associated with Escherichia Coli Infections
RGD
PMID:27845343
RGD:42722624
NCBI chr17:4,980,083...4,983,219
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GRK2
G protein-coupled receptor kinase 2
ISO
mRNA:decreased expression:polymorphonuclear leukocyte
RGD
PMID:24465168
RGD:126848796
NCBI chr11:62,624,647...62,644,846
Ensembl chr11:65,939,164...65,959,066
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ICAM1
intercellular adhesion molecule 1
ISO
protein:increased expression:lung (mouse)
RGD
PMID:19846873
RGD:4145490
NCBI chr19:9,821,402...9,837,021
Ensembl chr19:10,484,414...10,500,605
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IFNAR1
interferon alpha and beta receptor subunit 1
severity
ISO
RGD
PMID:19487810
RGD:5490274
NCBI chr21:19,683,496...19,719,034
Ensembl chr21:33,058,396...33,093,824
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IFNG
interferon gamma
severity
ISO
RGD
PMID:25398094
RGD:38501102
NCBI chr12:65,663,764...65,668,732
Ensembl chr12:68,448,861...68,453,829
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IL10
interleukin 10
severity
ISO
RGD
PMID:25398094
RGD:38501102
NCBI chr 1:182,369,234...182,374,207
Ensembl chr 1:186,648,289...186,653,371
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IL15
interleukin 15
ISO
RGD
PMID:17911627
RGD:5000754
NCBI chr 4:133,693,995...134,115,470
Ensembl chr 4:145,402,111...145,416,622
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IL17A
interleukin 17A
severity
ISO
RGD
PMID:18802100 PMID:25398094
RGD:38501102 RGD:4889153
NCBI chr 6:51,736,269...51,740,538
Ensembl chr 6:53,004,820...53,009,074
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IL18
interleukin 18
ISO
RGD
PMID:17664259
RGD:4889913
NCBI chr11:107,024,376...107,045,194
Ensembl chr11:110,867,586...110,888,371
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IL1B
interleukin 1 beta
treatment severity
ISO
associated with Agranulocytosis
RGD
PMID:7546648 PMID:18596024 PMID:25398094
RGD:10755357 RGD:38501102 RGD:4143205
NCBI chr2A:89,216,313...89,223,358
Ensembl chr2A:113,846,306...113,853,424
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IL1RL1
interleukin 1 receptor like 1
treatment
ISO
associated with Sepsis associated with Acinetobacter infectious disease
RGD
PMID:20959556 PMID:29508184
RGD:40818077 RGD:5144223
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IL1RN
interleukin 1 receptor antagonist
ISO
RGD
PMID:18322242 PMID:18596024
RGD:4143205 RGD:4143206
NCBI chr2A:88,991,646...89,008,013
Ensembl chr2A:114,061,182...114,078,839
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IL6
interleukin 6
severity
ISO
RGD
PMID:25398094
RGD:38501102
NCBI chr 7:23,415,922...23,420,767
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IRAK3
interleukin 1 receptor associated kinase 3
ISO
RGD
PMID:20439918 PMID:28120642
RGD:34888234 RGD:36049799
NCBI chr12:22,661,613...22,721,203
Ensembl chr12:23,168,346...23,227,148
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IRF1
interferon regulatory factor 1
ISO
RGD
PMID:11854220
RGD:5128725
NCBI chr 5:127,903,887...127,913,843
Ensembl chr 5:134,067,441...134,075,035
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IRF3
interferon regulatory factor 3
ISO
RGD
PMID:20720199
RGD:4891951
NCBI chr19:46,674,193...46,680,464
Ensembl chr19:55,593,627...55,599,903
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ITGB3
integrin subunit beta 3
ISO
protein:increased expression:lung, neutrophil
RGD
PMID:15114484
RGD:4993468
NCBI chr17:10,134,450...10,194,596
Ensembl chr17:10,353,111...10,392,382
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LEP
leptin
ISO
RGD
PMID:11937559
RGD:5128871
NCBI chr 7:120,230,896...120,248,602
Ensembl chr 7:132,885,011...132,901,519
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LOC100974886
uncharacterized LOC100974886
severity
ISO
RGD
PMID:11052817 PMID:19239431 PMID:21723409
RGD:5135062 RGD:5135065 RGD:5135234
NCBI chr 4:50,092,989...50,095,541
Ensembl chr 4:55,925,562...55,986,555
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LOC100976904
growth-regulated alpha protein
ISO
RGD
PMID:11052817 PMID:21723409
RGD:5135062 RGD:5135234
NCBI chr 4:50,325,248...50,327,165
Ensembl chr 4:56,153,899...56,159,474
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LOC103783265
pulmonary surfactant-associated protein A1
ISO
protein:increased expression:lung
RGD
PMID:12169586
RGD:4143464
NCBI chr10:76,571,312...76,575,820
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MAPK8
mitogen-activated protein kinase 8
severity
ISO
associated with Escherichia Coli Infections
RGD
PMID:22514650
RGD:150340681
NCBI chr10:45,806,748...45,936,362
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MBL2
mannose binding lectin 2
ISO
Legionella Pneumonia; DNA:mutations:5' utr, exon:multiple (human)
RGD
PMID:18641104
RGD:4889477
NCBI chr10:49,401,364...49,409,328
Ensembl chr10:51,527,758...51,543,432
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MC1R
melanocortin 1 receptor
ISO
RGD
PMID:18304533
RGD:5687324
NCBI chr16:70,676,447...70,697,636
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MMP9
matrix metallopeptidase 9
ISO
protein:increased expression:bronchoalveolar lavage fluid
RGD
PMID:17202364 PMID:19535150
RGD:5129533 RGD:5130727
NCBI chr20:42,346,305...42,354,018
Ensembl chr20:43,432,389...43,440,129
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MPO
myeloperoxidase
ISO
protein:increased activity:bronchoalveolar lavage Fluid:
RGD
PMID:11269653
RGD:5130992
NCBI chr17:52,333,882...52,357,838
Ensembl chr17:57,201,073...57,212,111
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NOD1
nucleotide binding oligomerization domain containing 1
ISO
RGD
PMID:19360122
RGD:5131449
NCBI chr 7:31,060,245...31,109,012
Ensembl chr 7:31,182,275...31,208,742
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NOD2
nucleotide binding oligomerization domain containing 2
ISO
RGD
PMID:19360122
RGD:5131449
NCBI chr16:30,955,976...30,995,451
Ensembl chr16:49,837,891...49,873,773
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PDPN
podoplanin
ISO
protein:increased expression:lung
RGD
PMID:7864138
RGD:2292375
NCBI chr 1:12,728,569...12,759,781
Ensembl chr 1:13,728,233...13,759,584
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PECAM1
platelet and endothelial cell adhesion molecule 1
ISO
protein:decreased expression:lung
RGD
PMID:12524254
RGD:724645
NCBI chr17:58,417,134...58,526,409
Ensembl chr17:63,511,784...63,579,067
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PGF
placental growth factor
ISO
protein:increased expression:plasma
RGD
PMID:16702604
RGD:6483601
NCBI chr14:55,494,152...55,508,066
Ensembl chr14:74,338,976...74,352,964
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PTEN
phosphatase and tensin homolog
ameliorates
ISO
myeloid knockout
RGD
PMID:21527775
RGD:127285594
NCBI chr10:84,587,841...84,689,043
Ensembl chr10:88,093,539...88,194,605
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RIPK3
receptor interacting serine/threonine kinase 3
ameliorates
ISO
RGD
PMID:28387756
RGD:127229944
NCBI chr14:5,112,512...5,116,486
Ensembl chr14:23,235,796...23,239,821
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RORC
RAR related orphan receptor C
severity
ISO
RGD
PMID:25398094
RGD:38501102
NCBI chr 1:127,164,725...127,190,479
Ensembl chr 1:130,808,705...130,834,490
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SERPINE1
serpin family E member 1
severity
ISO
RGD
PMID:17032919
RGD:4144840
NCBI chr 7:93,267,517...93,279,728
Ensembl chr 7:106,510,130...106,518,450
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SFTPB
surfactant protein B
ISO
associated with Cystic Fibrosis;protein:increased expression:lung
RGD
PMID:12169586 PMID:15271694
RGD:4143403 RGD:4143464
NCBI chr2A:85,708,485...85,718,120
Ensembl chr2A:87,257,244...87,268,332
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SFTPC
surfactant protein C
ISO
RGD
PMID:12169586 PMID:18566429
RGD:4143464 RGD:4144114
NCBI chr 8:21,402,060...21,409,438
Ensembl chr 8:18,345,940...18,348,764
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SFTPD
surfactant protein D
ISO
protein:increased expression:lung associated with Cystic Fibrosis;protein:decreased expression:lung
RGD
PMID:12169586 PMID:15271694
RGD:4143403 RGD:4143464
NCBI chr10:76,275,147...76,318,952
Ensembl chr10:78,965,252...78,974,181
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STAT3
signal transducer and activator of transcription 3
ISO
RGD
PMID:18192501
RGD:6892945
NCBI chr17:14,928,689...15,003,644
Ensembl chr17:15,152,358...15,227,067
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TGFB1
transforming growth factor beta 1
severity
ISO
RGD
PMID:25398094
RGD:38501102
NCBI chr19:38,324,009...38,347,003
Ensembl chr19:46,831,659...46,852,973
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TLR2
toll like receptor 2
ISO
RGD
PMID:18768871 PMID:19844782
RGD:4145337 RGD:4889533
NCBI chr 4:146,024,653...146,091,388
Ensembl chr 4:157,866,977...157,869,331
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TLR4
toll like receptor 4
ISO
RGD
PMID:16210672 PMID:20650991
RGD:4144172 RGD:4144197
NCBI chr 9:88,827,495...88,840,458
Ensembl chr 9:117,180,550...117,190,711
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TLR5
toll like receptor 5
ISO
RGD
PMID:19801452
RGD:5129503
NCBI chr 1:198,787,046...198,819,537
Ensembl chr 1:203,798,767...203,801,343
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TLR6
toll like receptor 6
ISO
RGD
PMID:19844782
RGD:4889533
NCBI chr 4:33,153,151...33,174,053
Ensembl chr 4:39,009,103...39,011,490
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TNF
tumor necrosis factor
severity treatment disease_progression
ISO
associated with Agranulocytosis
RGD
PMID:7546648 PMID:9310939 PMID:10650487 PMID:12958055
RGD:10449451 RGD:10450564 RGD:10755357 RGD:4143476
NCBI chr 6:31,236,650...31,239,423
Ensembl chr 6:32,126,618...32,129,381
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TNFRSF1A
TNF receptor superfamily member 1A
ISO
protein:increased expression:serum (mouse)
RGD
PMID:19842848
RGD:5131429
NCBI chr12:6,457,617...6,470,969
Ensembl chr12:6,374,257...6,387,613
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TNFRSF1B
TNF receptor superfamily member 1B
ISO
protein:increased expression:serum (mouse)
RGD
PMID:19842848
RGD:5131429
NCBI chr 1:10,915,743...10,957,765
Ensembl chr 1:12,130,663...12,172,646
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TREM1
triggering receptor expressed on myeloid cells 1
severity ameliorates
ISO
RGD
PMID:16960786 PMID:22996209 PMID:24465168
RGD:126848796 RGD:126925987 RGD:127229902
NCBI chr 6:40,861,283...40,874,446
Ensembl chr 6:42,163,337...42,183,091
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ZC3H12A
zinc finger CCCH-type containing 12A
ISO
associated with Pseudomonas Infections
RGD
PMID:29695841
RGD:39938967
NCBI chr 1:36,743,341...36,753,261
Ensembl chr 1:38,093,917...38,103,556
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CD274
CD274 molecule
ISO
mRNA:increased expression:lung
RGD
PMID:26378990
RGD:41412180
NCBI chr 9:5,269,270...5,289,629
Ensembl chr 9:5,454,391...5,474,402
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PDCD1
programmed cell death 1
ISO
mRNA:increased expression:lung
RGD
PMID:26378990
RGD:41412180
NCBI chr12:130,849,353...130,858,776
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PIK3CD
phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit delta
severity
ISO
RGD
PMID:29893841
RGD:40890270
NCBI chr 1:8,418,570...8,495,435
Ensembl chr 1:9,686,208...9,724,633
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CXCL8
C-X-C motif chemokine ligand 8
ISO
RGD
PMID:11207292
RGD:38549344
NCBI chr 4:50,452,857...50,456,015
Ensembl chr 4:56,286,708...56,288,083
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IL23A
interleukin 23 subunit alpha
severity
ISO
RGD
PMID:16157683
RGD:39457940
NCBI chr12:32,575,321...32,576,856
Ensembl chr12:32,828,902...32,830,617
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IRAK3
interleukin 1 receptor associated kinase 3
severity
ISO
mRNA:increased expression:lung (mouse)
RGD
PMID:20864681 PMID:22729155
RGD:35316077 RGD:36049798
NCBI chr12:22,661,613...22,721,203
Ensembl chr12:23,168,346...23,227,148
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LCN2
lipocalin 2
ameliorates exacerbates
ISO
protein:increased expression:serum protein:increased expression:lung
RGD
PMID:19342674 PMID:25234944 PMID:29633303
RGD:126725082 RGD:126725084 RGD:126725085
NCBI chr 9:99,259,278...99,274,494
Ensembl chr 9:127,940,799...127,944,798
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PLAC8
placenta associated 8
severity
ISO
RGD
PMID:17404296
RGD:40924563
NCBI chr 4:41,089,847...41,115,061
Ensembl chr 4:46,943,940...46,964,131
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TREM1
triggering receptor expressed on myeloid cells 1
disease_progression
ISO
RGD
PMID:24396044
RGD:126925976
NCBI chr 6:40,861,283...40,874,446
Ensembl chr 6:42,163,337...42,183,091
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ADA
adenosine deaminase
ISO
protein:increased expression:serum
RGD
PMID:9255891
RGD:5128857
NCBI chr20:40,950,238...40,982,481
Ensembl chr20:42,044,613...42,076,868
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CX3CL1
C-X3-C motif chemokine ligand 1
ISO
RGD
PMID:16113250
RGD:4891897
NCBI chr16:37,646,447...37,659,078
Ensembl chr16:56,779,065...56,791,760
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CXCL6
C-X-C motif chemokine ligand 6
ISO
mRNA, protein:increased expression:lung
RGD
PMID:11254553
RGD:5135252
NCBI chr 4:50,357,643...50,359,822
Ensembl chr 4:56,189,961...56,192,402
G
CXCR2
C-X-C motif chemokine receptor 2
ISO
RGD
PMID:11254553
RGD:5135252
NCBI chr2B:105,387,198...105,400,533
Ensembl chr2B:223,997,066...223,998,148
G
IFNG
interferon gamma
ISO
CTD Direct Evidence: therapeutic
CTD
PMID:11349020
NCBI chr12:65,663,764...65,668,732
Ensembl chr12:68,448,861...68,453,829
G
IL18
interleukin 18
ISO
RGD
PMID:11083766
RGD:4889865
NCBI chr11:107,024,376...107,045,194
Ensembl chr11:110,867,586...110,888,371
G
LOC100974886
uncharacterized LOC100974886
ISO
mRNA, protein:increased expression:lung
RGD
PMID:11254553
RGD:5135252
NCBI chr 4:50,092,989...50,095,541
Ensembl chr 4:55,925,562...55,986,555
G
LOC100976904
growth-regulated alpha protein
ISO
mRNA, protein:increased expression:lung
RGD
PMID:11254553
RGD:5135252
NCBI chr 4:50,325,248...50,327,165
Ensembl chr 4:56,153,899...56,159,474
G
MBL2
mannose binding lectin 2
susceptibility
ISO
RGD
PMID:19073229
RGD:12910934
NCBI chr10:49,401,364...49,409,328
Ensembl chr10:51,527,758...51,543,432
G
NOD1
nucleotide binding oligomerization domain containing 1
ISO
RGD
PMID:20685341
RGD:5131443
NCBI chr 7:31,060,245...31,109,012
Ensembl chr 7:31,182,275...31,208,742
G
NOD2
nucleotide binding oligomerization domain containing 2
ISO
RGD
PMID:20685341
RGD:5131443
NCBI chr16:30,955,976...30,995,451
Ensembl chr16:49,837,891...49,873,773
G
TLR5
toll like receptor 5
susceptibility
ISO
ClinVar Annotator: match by term: Legionnaire disease, susceptibility to
ClinVar OMIM
PMID:14623910 PMID:16027372 PMID:23447684
NCBI chr 1:198,787,046...198,819,537
Ensembl chr 1:203,798,767...203,801,343
G
TNFRSF1A
TNF receptor superfamily member 1A
ISO
RGD
PMID:18838275
RGD:5131445
NCBI chr12:6,457,617...6,470,969
Ensembl chr12:6,374,257...6,387,613
G
TNFRSF1B
TNF receptor superfamily member 1B
ISO
RGD
PMID:18838275
RGD:5131445
NCBI chr 1:10,915,743...10,957,765
Ensembl chr 1:12,130,663...12,172,646
G
ADA
adenosine deaminase
ISO
protein:increased expression:serum
RGD
PMID:9255891
RGD:5128857
NCBI chr20:40,950,238...40,982,481
Ensembl chr20:42,044,613...42,076,868
G
ATP1B2
ATPase Na+/K+ transporting subunit beta 2
severity
ISO
RGD
PMID:28302172
RGD:32716376
NCBI chr17:7,681,831...7,688,710
Ensembl chr17:7,669,626...7,673,834
G
CCL5
C-C motif chemokine ligand 5
ISO
protein:increased secretion:lung, secretion (mouse)
RGD
PMID:18717637
RGD:4891914
NCBI chr17:20,915,198...20,923,530
Ensembl chr17:21,210,798...21,219,172
G
CCL8
C-C motif chemokine ligand 8
ISO
RGD
PMID:16988274
RGD:4892091
NCBI chr17:22,468,080...22,470,443
Ensembl chr17:22,761,064...22,763,933
G
CCR5
C-C motif chemokine receptor 5
ISO
protein:increased expression:lung, T-helper cell (mouse)
RGD
PMID:16988274
RGD:4892091
NCBI chr 3:46,273,096...46,278,471
Ensembl chr 3:47,380,321...47,381,379
G
CLEC5A
C-type lectin domain containing 5A
severity
ISO
RGD
PMID:28302172
RGD:32716376
NCBI chr 7:133,851,242...133,870,793
Ensembl chr 7:146,320,331...146,339,905
G
COL3A1
collagen type III alpha 1 chain
severity
ISO
RGD
PMID:28302172
RGD:32716376
NCBI chr2B:76,285,115...76,322,703
Ensembl chr2B:194,204,613...194,242,956
G
COL6A1
collagen type VI alpha 1 chain
severity
ISO
RGD
PMID:28302172
RGD:32716376
NCBI chr21:32,322,185...32,346,850
Ensembl chr21:45,584,096...45,607,240
G
COL6A2
collagen type VI alpha 2 chain
severity
ISO
RGD
PMID:28302172
RGD:32716376
NCBI chr21:32,442,859...32,478,076
Ensembl chr21:45,710,491...45,730,895
G
CRP
C-reactive protein
ISO
RGD
PMID:21426633
RGD:5131292
NCBI chr 1:135,062,102...135,064,402
G
DNASE1L3
deoxyribonuclease 1L3
severity
ISO
RGD
PMID:28302172
RGD:32716376
NCBI chr 3:58,127,491...58,146,177
Ensembl chr 3:59,542,243...59,560,363
G
FCER2
Fc epsilon receptor II
severity
ISO
RGD
PMID:28302172
RGD:32716376
NCBI chr19:6,978,116...6,989,986
Ensembl chr19:7,834,106...7,844,924
G
FLT1
fms related receptor tyrosine kinase 1
severity
ISO
RGD
PMID:28302172
RGD:32716376
NCBI chr13:9,584,850...9,779,542
G
GALC
galactosylceramidase
ISO
protein:increased expression:serum (mouse) associated with Guillain-Barre syndrome; protein:increased expression:Cerebrospinal fluid, serum (human) protein:increased expression:serum (human) associated with Guillain-Barre syndrome; protein:increased expression:serum (human)
RGD
PMID:12225900 PMID:27490360 PMID:29301655 PMID:30396892
RGD:38599168 RGD:38599169 RGD:38599171 RGD:38599172
NCBI chr14:68,545,070...68,605,730
Ensembl chr14:87,905,098...87,965,770
G
HDC
histidine decarboxylase
ISO
RGD
PMID:17158962
RGD:5143920
NCBI chr15:29,188,296...29,212,327
Ensembl chr15:47,510,629...47,534,577
G
HTRA3
HtrA serine peptidase 3
severity
ISO
RGD
PMID:28302172
RGD:32716376
Ensembl chr 4:8,335,529...8,374,510
G
IFNG
interferon gamma
ISO
mRNA:increased expression:lung:
RGD
PMID:7935058
RGD:10755754
NCBI chr12:65,663,764...65,668,732
Ensembl chr12:68,448,861...68,453,829
G
IL13
interleukin 13
ISO
protein:increased expression:serum
RGD
PMID:20416219
RGD:4145765
NCBI chr 5:128,073,863...128,078,453
Ensembl chr 5:134,235,788...134,240,548
G
IL22RA2
interleukin 22 receptor subunit alpha 2
severity
ISO
RGD
PMID:28302172
RGD:32716376
NCBI chr 6:134,904,634...134,934,328
Ensembl chr 6:138,992,202...139,021,843
G
INHBA
inhibin subunit beta A
severity
ISO
RGD
PMID:28302172
RGD:32716376
NCBI chr 7:42,538,591...42,556,578
Ensembl chr 7:42,580,730...42,595,097
G
KLRF1
killer cell lectin like receptor F1
severity
ISO
RGD
PMID:28302172
RGD:32716376
NCBI chr12:9,875,505...9,893,012
Ensembl chr12:10,124,779...10,142,237
G
MS4A1
membrane spanning 4-domains A1
severity
ISO
RGD
PMID:28302172
RGD:32716376
NCBI chr11:55,691,750...55,706,697
Ensembl chr11:59,134,617...59,149,521
G
PLD4
phospholipase D family member 4
severity
ISO
RGD
PMID:28302172
RGD:32716376
NCBI chr14:85,574,724...85,587,176
Ensembl chr14:105,360,584...105,369,247
G
SPIB
Spi-B transcription factor
severity
ISO
RGD
PMID:28302172
RGD:32716376
NCBI chr19:47,382,653...47,395,178
Ensembl chr19:56,251,356...56,297,611
G
TCF7
transcription factor 7
severity
ISO
RGD
PMID:28302172
RGD:32716376
NCBI chr 5:129,518,134...129,549,972
Ensembl chr 5:135,671,095...135,702,734
G
TCL1A
TCL1 family AKT coactivator A
severity
ISO
RGD
PMID:28302172
RGD:32716376
NCBI chr14:76,339,614...76,343,546
Ensembl chr14:95,664,120...95,667,375
G
TNF
tumor necrosis factor
ISO
protein:increased expression:serum
RGD
PMID:20416219
RGD:4145765
NCBI chr 6:31,236,650...31,239,423
Ensembl chr 6:32,126,618...32,129,381
G
TNFRSF13C
TNF receptor superfamily member 13C
severity
ISO
RGD
PMID:28302172
RGD:32716376
NCBI chr22:22,816,504...22,819,584
G
AICDA
activation induced cytidine deaminase
ISO
RGD
PMID:26456931
RGD:11098923
NCBI chr12:8,688,392...8,699,008
Ensembl chr12:8,904,273...8,913,917
G
ALOX5
arachidonate 5-lipoxygenase
ISO
RGD
PMID:20231413
RGD:4890435
NCBI chr10:42,461,398...42,531,576
Ensembl chr10:45,639,946...45,710,016
G
BTK
Bruton tyrosine kinase
ameliorates
ISO
RGD
PMID:30646846
RGD:124715470
NCBI chr X:90,551,874...90,588,786
Ensembl chr X:100,684,017...100,725,187
G
C3
complement C3
disease_progression
ISO
associated with Liver Cirrhosis, Experimental;protein:decreased expression:respiratory system fluid/secretion protein:decreased expression:serum
RGD
PMID:20405 PMID:15972516 PMID:17956621
RGD:5129509 RGD:5129523 RGD:5130163
NCBI chr19:5,708,211...5,753,178
Ensembl chr19:6,629,287...6,674,699
G
C5
complement C5
severity
ISO
RGD
PMID:7814608
RGD:5130159
NCBI chr 9:92,069,574...92,202,513
Ensembl chr 9:120,426,354...120,523,856
G
CCL5
C-C motif chemokine ligand 5
susceptibility
ISO
RGD
PMID:16455992
RGD:4892130
NCBI chr17:20,915,198...20,923,530
Ensembl chr17:21,210,798...21,219,172
G
CD14
CD14 molecule
ISO
RGD
PMID:17185649
RGD:4144788
NCBI chr 5:135,996,265...135,997,909
Ensembl chr 5:142,113,082...142,118,966
G
CHI3L1
chitinase 3 like 1
ISO
protein:increased secretion:serum (human)
RGD
PMID:10515841
RGD:4892626
NCBI chr 1:178,778,081...178,789,704
Ensembl chr 1:183,075,312...183,083,229
G
CRHR1
corticotropin releasing hormone receptor 1
ISO
RGD
PMID:21774994
RGD:5147472
NCBI chr17:11,261,435...11,313,630
Ensembl chr17:11,650,057...11,701,208
G
CRHR2
corticotropin releasing hormone receptor 2
ISO
RGD
PMID:21774994
RGD:5147472
NCBI chr 7:31,265,619...31,313,902
Ensembl chr 7:31,386,026...31,434,220
G
CRP
C-reactive protein
disease_progression
ISO
RGD
PMID:21281676
RGD:5131293
NCBI chr 1:135,062,102...135,064,402
G
CXCL8
C-X-C motif chemokine ligand 8
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:24894820
NCBI chr 4:50,452,857...50,456,015
Ensembl chr 4:56,286,708...56,288,083
G
CXCL9
C-X-C motif chemokine ligand 9
ISO
protein:increased expression:lung
RGD
PMID:20381636
RGD:5135285
NCBI chr 4:48,198,478...48,204,658
Ensembl chr 4:54,036,342...54,042,502
G
HMOX1
heme oxygenase 1
ISO
associated with influenza;protein:increased expression:lung
RGD
PMID:17348295
RGD:4145366
NCBI chr22:16,388,368...16,401,289
Ensembl chr22:34,230,825...34,244,063
G
IL15
interleukin 15
ISO
protein:increased expression:alveolar macrophage, bronchial epithelial cell
RGD
PMID:17611121
RGD:5000755
NCBI chr 4:133,693,995...134,115,470
Ensembl chr 4:145,402,111...145,416,622
G
IL15RA
interleukin 15 receptor subunit alpha
ISO
RGD
PMID:17611121
RGD:5000755
NCBI chr10:5,993,583...6,019,967
G
IL17A
interleukin 17A
ISO
RGD
PMID:19995896
RGD:4888531
NCBI chr 6:51,736,269...51,740,538
Ensembl chr 6:53,004,820...53,009,074
G
IL18
interleukin 18
ISO
RGD
PMID:15770015
RGD:4889960
NCBI chr11:107,024,376...107,045,194
Ensembl chr11:110,867,586...110,888,371
G
IL6
interleukin 6
ISO
RGD
PMID:20643849
RGD:4143255
NCBI chr 7:23,415,922...23,420,767
G
LEP
leptin
ISO
RGD
PMID:17822444
RGD:5128869
NCBI chr 7:120,230,896...120,248,602
Ensembl chr 7:132,885,011...132,901,519
G
LEPR
leptin receptor
ISO
RGD
PMID:21148797
RGD:5128846
NCBI chr 1:64,772,612...64,881,886
Ensembl chr 1:66,693,926...66,764,768
G
LOC100976904
growth-regulated alpha protein
ISO
protein:increased expression:respiratory system fluid/secretion
RGD
PMID:20958976
RGD:5134957
NCBI chr 4:50,325,248...50,327,165
Ensembl chr 4:56,153,899...56,159,474
G
MAPK1
mitogen-activated protein kinase 1
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:24894820
NCBI chr22:3,883,119...3,990,368
Ensembl chr22:20,365,487...20,450,335
G
MAPK3
mitogen-activated protein kinase 3
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:24894820
Ensembl chr16:30,489,362...30,498,017
G
MASP2
MBL associated serine protease 2
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:12904520
NCBI chr 1:9,787,565...9,810,276
Ensembl chr 1:11,009,760...11,030,734
G
MBL2
mannose binding lectin 2
no_association
ISO
DNA:polymorphisms:5' utr, exon:multiple (human) DNA:mutations:5' utr, exon:multiple (human)
RGD
PMID:12047967 PMID:18641104
RGD:4889477 RGD:4889478
NCBI chr10:49,401,364...49,409,328
Ensembl chr10:51,527,758...51,543,432
G
NOS2
nitric oxide synthase 2
ISO
RGD
PMID:17056580
RGD:4891950
NCBI chr17:28,984,295...29,021,516
Ensembl chr17:29,471,510...29,617,093
G
PTEN
phosphatase and tensin homolog
ameliorates
ISO
myeloid knockout
RGD
PMID:20505137
RGD:127285597
NCBI chr10:84,587,841...84,689,043
Ensembl chr10:88,093,539...88,194,605
G
SFTPD
surfactant protein D
severity
ISO
RGD
PMID:16255775
RGD:4143519
NCBI chr10:76,275,147...76,318,952
Ensembl chr10:78,965,252...78,974,181
G
SIRT1
sirtuin 1
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:24894820
NCBI chr10:64,368,878...64,401,684
Ensembl chr10:66,681,598...66,715,069
G
STING1
stimulator of interferon response cGAMP interactor 1
ISO
RGD
PMID:29263110
RGD:39128230
NCBI chr 5:134,845,689...134,852,938
Ensembl chr 5:140,967,399...140,973,846
G
TLR2
toll like receptor 2
ISO
RGD
PMID:19956717
RGD:4145321
NCBI chr 4:146,024,653...146,091,388
Ensembl chr 4:157,866,977...157,869,331
G
TNF
tumor necrosis factor
ISO
associated with influenza;protein:increased expression:lung
RGD
PMID:9032201 PMID:17348295
RGD:4143479 RGD:4145366
NCBI chr 6:31,236,650...31,239,423
Ensembl chr 6:32,126,618...32,129,381
G
TREM1
triggering receptor expressed on myeloid cells 1
ameliorates
ISO
RGD
PMID:19596984 PMID:24752755
RGD:126928121 RGD:127229903
NCBI chr 6:40,861,283...40,874,446
Ensembl chr 6:42,163,337...42,183,091
G
IDO1
indoleamine 2,3-dioxygenase 1
ISO
RGD
PMID:20385761
RGD:39938865
NCBI chr 8:39,108,310...39,123,611
Ensembl chr 8:36,617,312...36,632,352
G
AKT1
AKT serine/threonine kinase 1
treatment
ISO
RGD
PMID:23613163
RGD:38676477
NCBI chr14:85,417,229...85,444,722
Ensembl chr14:105,208,128...105,236,756
G
CD86
CD86 molecule
ISO
protein:decreased expression:spleen, plasmacytoid dendritic cell (mouse)
RGD
PMID:20949109
RGD:4892562
NCBI chr 3:119,151,884...119,217,641
Ensembl chr 3:126,059,008...126,124,339
G
CFTR
CF transmembrane conductance regulator
ISO
RGD
PMID:28289144
RGD:36049750
NCBI chr 7:109,449,847...109,633,023
Ensembl chr 7:122,129,798...122,327,864
G
CSF3
colony stimulating factor 3
treatment
ISO
RGD
PMID:10228098
RGD:11039478
NCBI chr17:17,271,074...17,273,493
Ensembl chr17:17,491,276...17,493,729
G
FN1
fibronectin 1
ISO
RGD
PMID:12065530
RGD:7205474
NCBI chr2B:102,623,568...102,698,747
Ensembl chr2B:221,208,431...221,284,003
G
IFNAR1
interferon alpha and beta receptor subunit 1
susceptibility
ISO
RGD
PMID:19603548
RGD:5490273
NCBI chr21:19,683,496...19,719,034
Ensembl chr21:33,058,396...33,093,824
G
IL10
interleukin 10
ISO
mRNA, protein:increased expression:lung
RGD
PMID:22940620
RGD:7364825
NCBI chr 1:182,369,234...182,374,207
Ensembl chr 1:186,648,289...186,653,371
G
IL15
interleukin 15
ISO
RGD
PMID:18390740
RGD:4996474
NCBI chr 4:133,693,995...134,115,470
Ensembl chr 4:145,402,111...145,416,622
G
IL1B
interleukin 1 beta
ISO
RGD
PMID:20065029
RGD:4142828
NCBI chr2A:89,216,313...89,223,358
Ensembl chr2A:113,846,306...113,853,424
G
IL33
interleukin 33
ISO
mRNA:increased expression:lung:
RGD
PMID:28401938
RGD:40400699
NCBI chr 9:6,027,014...6,069,540
Ensembl chr 9:6,234,178...6,248,624
G
NOD2
nucleotide binding oligomerization domain containing 2
ISO
RGD
PMID:20493961
RGD:5131444
NCBI chr16:30,955,976...30,995,451
Ensembl chr16:49,837,891...49,873,773
G
PRKN
parkin RBR E3 ubiquitin protein ligase
ISO
protein:increased expression:lung (mouse)
RGD
PMID:28663335
RGD:13432209
NCBI chr 6:159,293,016...160,679,106
Ensembl chr 6:164,314,990...165,678,770
G
PTPN11
protein tyrosine phosphatase non-receptor type 11
severity
ISO
associated with influenza mRNA:increased expression:lung
RGD
PMID:31782850
RGD:39131288
NCBI chr12:110,016,364...110,107,462
Ensembl chr12:113,435,669...113,503,762
G
RIPK3
receptor interacting serine/threonine kinase 3
treatment
ISO
RGD
PMID:25445964
RGD:127229910
NCBI chr14:5,112,512...5,116,486
Ensembl chr14:23,235,796...23,239,821
G
SFTPB
surfactant protein B
ameliorates
ISO
RGD
PMID:20007532
RGD:151667448
NCBI chr2A:85,708,485...85,718,120
Ensembl chr2A:87,257,244...87,268,332
G
ATM
ATM serine/threonine kinase
exacerbates
ISO
RGD
PMID:27421701
RGD:126779562
NCBI chr11:103,109,979...103,256,405
Ensembl chr11:106,584,228...106,727,041
G
BTK
Bruton tyrosine kinase
ISO
RGD
PMID:30873567
RGD:124715473
NCBI chr X:90,551,874...90,588,786
Ensembl chr X:100,684,017...100,725,187
G
IDO1
indoleamine 2,3-dioxygenase 1
ISO
mRNA:increased expression:lung (mouse)
RGD
PMID:20385761
RGD:39938865
NCBI chr 8:39,108,310...39,123,611
Ensembl chr 8:36,617,312...36,632,352
G
IFNG
interferon gamma
ISO
protein:increased expression:lung,natural killer cell (mouse)
RGD
PMID:21887255
RGD:40818252
NCBI chr12:65,663,764...65,668,732
Ensembl chr12:68,448,861...68,453,829
G
IL6
interleukin 6
ISO
protein:increased expression:lung,natural killer cell (mouse)
RGD
PMID:21887255
RGD:40818252
NCBI chr 7:23,415,922...23,420,767
G
IRAK3
interleukin 1 receptor associated kinase 3
severity
ISO
RGD
PMID:22492852
RGD:35316076
NCBI chr12:22,661,613...22,721,203
Ensembl chr12:23,168,346...23,227,148
G
ITGB2
integrin subunit beta 2
susceptibility
ISO
RGD
PMID:11390487
RGD:127345090
NCBI chr21:31,181,228...31,216,033
Ensembl chr21:44,470,999...44,505,963
G
LAMP1
lysosomal associated membrane protein 1
ISO
protein:increased expression:lung, natural killer cell (mouse)
RGD
PMID:21887255
RGD:40818252
NCBI chr13:94,442,507...94,464,061
Ensembl chr13:113,507,401...113,530,457
G
LOC100978434
C-type lectin domain family 4 member M
severity
ISO
RGD
PMID:16134084
RGD:39938986
NCBI chr19:7,062,961...7,069,381
G
MARCO
macrophage receptor with collagenous structure
exacerbates
ISO
RGD
PMID:15263032
RGD:41412189
NCBI chr2B:5,896,433...5,940,284
Ensembl chr2B:119,475,677...119,520,385
G
NCR1
natural cytotoxicity triggering receptor 1
severity
ISO
RGD
PMID:21887255
RGD:40818252
NCBI chr19:51,951,496...51,957,433
Ensembl chr19:60,645,677...60,652,274
G
PDCD1
programmed cell death 1
treatment
ISO
RGD
PMID:25624454
RGD:40818422
NCBI chr12:130,849,353...130,858,776
G
PIK3CD
phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit delta
treatment
ISO
associated with immunodeficiency 14
RGD
PMID:30093657
RGD:40890269
NCBI chr 1:8,418,570...8,495,435
Ensembl chr 1:9,686,208...9,724,633
G
PIK3CG
phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma
severity
ISO
RGD
PMID:17322108
RGD:38599154
NCBI chr 7:98,841,974...98,885,446
Ensembl chr 7:111,570,148...111,611,614
G
RIPK3
receptor interacting serine/threonine kinase 3
exacerbates
ISO
RGD
PMID:33625952
RGD:127229925
NCBI chr14:5,112,512...5,116,486
Ensembl chr14:23,235,796...23,239,821
G
TNF
tumor necrosis factor
ISO
protein:increased expression:lung,natural killer cell (mouse)
RGD
PMID:21887255
RGD:40818252
NCBI chr 6:31,236,650...31,239,423
Ensembl chr 6:32,126,618...32,129,381
Term paths to the root one shortest all shortest one longest all longest one shortest and longest all