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RGD DISEASE ONTOLOGY - ANNOTATIONS

RGD uses the Human Disease Ontology (DO, https://disease-ontology.org/) for disease curation across species. RGD automatically downloads each new release of the ontology on a monthly basis. Some additional terms which are required for RGD's curation purposes but are not currently covered in the official version of DO have been added. As corresponding terms are added to DO, these custom terms are retired and the DO terms substituted in existing annotations and subsequently used for curation.

Term:Drug-Induced Dyskinesia
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Accession:DOID:9008394 term browser browse the term
Definition:Abnormal movements, including HYPERKINESIS; HYPOKINESIA; TREMOR; and DYSTONIA, associated with the use of certain medications or drugs. Muscles of the face, trunk, neck, and extremities are most commonly affected. Tardive dyskinesia refers to abnormal hyperkinetic movements of the muscles of the face, tongue, and neck associated with the use of neuroleptic agents (see ANTIPSYCHOTIC AGENTS). (Adams et al., Principles of Neurology, 6th ed, p1199)
Synonyms:exact_synonym: Drug-Induced Dyskinesias;   Medication Induced Dyskinesia;   Medication-Induced Dyskinesias
 primary_id: MESH:D004409
 xref: EFO:1000904


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Drug-Induced Dyskinesia term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abat 4-aminobutyrate aminotransferase ISO RGD PMID:6445277 PMID:7740056 RGD:10047091 RGD:1598524 NCBI chrNW_004936530:7,543,743...7,621,392
Ensembl chrNW_004936530:7,543,682...7,622,667
JBrowse link
G Cacna1d calcium voltage-gated channel subunit alpha1 D ISO RGD PMID:18947822 RGD:6906919 NCBI chrNW_004936473:4,164,633...4,479,866
Ensembl chrNW_004936473:4,037,533...4,478,073
JBrowse link
G Cat catalase ISO CTD Direct Evidence: marker/mechanism CTD PMID:19109989 NCBI chrNW_004936533:3,601,270...3,637,128
Ensembl chrNW_004936533:3,600,955...3,637,422
JBrowse link
G Cck cholecystokinin ISO CTD Direct Evidence: therapeutic CTD PMID:2320253 NCBI chrNW_004936695:2,776,705...2,782,280
Ensembl chrNW_004936695:2,776,831...2,782,061
JBrowse link
G Comt catechol-O-methyltransferase ISO RGD PMID:16437585 RGD:2289781 NCBI chrNW_004936619:3,847,059...3,883,866
Ensembl chrNW_004936619:3,876,299...3,882,747
JBrowse link
G Dbn1 drebrin 1 ISO levodopainduced; protein:increased expression:striatum: RGD PMID:23241013 RGD:10398811 NCBI chrNW_004936597:1,735,589...1,751,628
Ensembl chrNW_004936597:1,735,380...1,747,569
JBrowse link
G Ddc dopa decarboxylase ISO associated with Parkinson Disease; protein:decreased expression:striatum (rat) RGD PMID:20232137 RGD:5128860 NCBI chrNW_004936686:1,322,153...1,405,434
Ensembl chrNW_004936686:1,301,207...1,405,384
JBrowse link
G Drd1 dopamine receptor D1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:7845605 PMID:10858612 PMID:16982285 PMID:19520364 NCBI chrNW_004936609:790,647...795,187
Ensembl chrNW_004936609:792,276...793,613
JBrowse link
G Drd2 dopamine receptor D2 ISO CTD Direct Evidence: marker/mechanism CTD
RGD
PMID:7845605 PMID:10534246 PMID:14629710 PMID:18707801 RGD:2311579 NCBI chrNW_004936612:1,094,686...1,154,149
Ensembl chrNW_004936612:1,094,680...1,154,798
JBrowse link
G Drd3 dopamine receptor D3 ISO CTD Direct Evidence: marker/mechanism CTD PMID:20945430 NCBI chrNW_004936536:1,580,732...1,616,726
Ensembl chrNW_004936536:1,580,732...1,616,725
JBrowse link
G Egr1 early growth response 1 ISO RGD PMID:22153973 RGD:10395307 NCBI chrNW_004936531:7,625,956...7,629,041
Ensembl chrNW_004936531:7,625,892...7,629,749
JBrowse link
G Fosb FosB proto-oncogene, AP-1 transcription factor subunit ISO CTD Direct Evidence: marker/mechanism CTD PMID:17219962 NCBI chrNW_004936706:1,900,954...1,907,567
Ensembl chrNW_004936706:1,900,931...1,906,772
JBrowse link
G Gad1 glutamate decarboxylase 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:9767399 NCBI chrNW_004936509:1,160,559...1,201,037
Ensembl chrNW_004936509:1,161,094...1,201,576
JBrowse link
G Gch1 GTP cyclohydrolase 1 ISO CTD Direct Evidence: therapeutic CTD PMID:15659429 NCBI chrNW_004936697:232,048...275,420 JBrowse link
G Gdnf glial cell derived neurotrophic factor ISO CTD Direct Evidence: therapeutic CTD PMID:11168568 NCBI chrNW_004936518:4,291,391...4,310,752
Ensembl chrNW_004936518:4,288,154...4,310,753
JBrowse link
G Glul glutamate-ammonia ligase ISO RGD PMID:6445277 RGD:10047091 NCBI chrNW_004936481:7,293,301...7,301,416
Ensembl chrNW_004936481:7,293,091...7,306,202
JBrowse link
G Grk6 G protein-coupled receptor kinase 6 ISO associated with Parkinson Disease RGD PMID:20410529 RGD:5684919 NCBI chrNW_004936597:1,706,671...1,722,370
Ensembl chrNW_004936597:1,706,665...1,722,370
JBrowse link
G Gsk3b glycogen synthase kinase 3 beta treatment ISO associated with Parkinsonian Disorders RGD PMID:26997328 RGD:13792768 NCBI chrNW_004936536:6,730,070...6,893,818
Ensembl chrNW_004936536:6,730,062...6,894,303
JBrowse link
G Homer1 homer scaffold protein 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:24126708 NCBI chrNW_004936549:7,189,588...7,320,117
Ensembl chrNW_004936549:7,188,850...7,320,312
JBrowse link
G Htr1a 5-hydroxytryptamine receptor 1A ISO RGD PMID:21352823 RGD:5683628 NCBI chrNW_004936480:5,042,531...5,047,157
Ensembl chrNW_004936480:5,043,204...5,044,472
JBrowse link
G LOC101961588 cytochrome P450 2D17 ISO RGD PMID:12629505 RGD:1358549 NCBI chrNW_004936718:153,340...157,966 JBrowse link
G Mapt microtubule associated protein tau treatment ISO associated with Parkinsonian Disorders RGD PMID:25511986 RGD:13800920 NCBI chrNW_004936541:2,381,411...2,479,984 JBrowse link
G Mtor mechanistic target of rapamycin kinase treatment ISO associated with Parkinsonian Disorders RGD PMID:23938307 RGD:10040953 NCBI chrNW_004936474:158,376...282,310
Ensembl chrNW_004936474:157,590...282,342
JBrowse link
G Pdyn prodynorphin treatment
severity
ISO CTD Direct Evidence: marker/mechanism
associated with Parkinsonism
associated with Parkinsonism;protein:increased expression:striatum
CTD
RGD
PMID:9767399 PMID:10869049 PMID:17884291 PMID:21737418 RGD:401850563 RGD:401851046 RGD:401900134 NCBI chrNW_004936485:16,559,371...16,571,461
Ensembl chrNW_004936485:16,559,217...16,571,678
JBrowse link
G Penk proenkephalin treatment
disease_progression
ISO mRNA:increased expression:brain:striatum:
CTD Direct Evidence: marker/mechanism
associated with Parkinsonism
associated with Parkinsonism;mRNA:increased expression:striatum
RGD
CTD
PMID:9767399 PMID:10869049 PMID:20456008 PMID:26113400 RGD:10003039 RGD:401851054 RGD:401900134 NCBI chrNW_004936496:3,016,247...3,021,726
Ensembl chrNW_004936496:3,016,218...3,021,738
JBrowse link
G Ppp1r1b protein phosphatase 1 regulatory inhibitor subunit 1B treatment ISO associated with Parkinsonian Disorders RGD PMID:27771532 RGD:13514053 NCBI chrNW_004936490:14,822,246...14,831,337
Ensembl chrNW_004936490:14,822,213...14,831,349
JBrowse link
G Rasgrf1 Ras protein specific guanine nucleotide releasing factor 1 ISO CTD Direct Evidence: therapeutic CTD PMID:21115823 NCBI chrNW_004936471:37,173,595...37,278,356
Ensembl chrNW_004936471:37,171,297...37,278,529
JBrowse link
G Rela RELA proto-oncogene, NF-kB subunit ISO protein:increased expression:nucleus, brain RGD PMID:18590723 RGD:2298778 NCBI chrNW_004936599:3,800,142...3,810,583
Ensembl chrNW_004936599:3,801,636...3,809,813
JBrowse link
G Rgs4 regulator of G protein signaling 4 treatment ISO associated with Parkinsonian Disorders RGD PMID:24969021 RGD:13524515 NCBI chrNW_004937238:101,948...109,513
Ensembl chrNW_004937238:102,061...109,474
JBrowse link
G Rgs9 regulator of G protein signaling 9 ISO CTD Direct Evidence: marker/mechanism|therapeutic CTD PMID:18160641 PMID:24663062 NCBI chrNW_004936541:7,472,195...7,525,220
Ensembl chrNW_004936541:7,458,539...7,525,220
JBrowse link
G Th tyrosine hydroxylase ISO CTD Direct Evidence: therapeutic CTD PMID:15659429 NCBI chrNW_004936794:478,651...486,887
Ensembl chrNW_004936794:478,614...487,061
JBrowse link
Tardive Dyskinesia term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Drd3 dopamine receptor D3 ISO associated with schizophrenia RGD PMID:12960753 RGD:1581250 NCBI chrNW_004936536:1,580,732...1,616,726
Ensembl chrNW_004936536:1,580,732...1,616,725
JBrowse link
G LOC101969421 cytochrome P450 1A2 treatment ISO associated with schizophrenia RGD PMID:10889552 RGD:1358545 NCBI chrNW_004936471:33,704,616...33,709,455
Ensembl chrNW_004936471:33,703,792...33,709,484
JBrowse link
G Sod2 superoxide dismutase 2 ISO associated with schizophrenia RGD PMID:12960753 RGD:1581250 NCBI chrNW_004936489:11,178,338...11,191,601
Ensembl chrNW_004936489:11,178,015...11,191,781
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  disease 14638
    syndrome 9984
      toxic encephalopathy 192
        Drug-Induced Dyskinesia 33
          Tardive Dyskinesia 3
Path 2
Term Annotations click to browse term
  disease 14638
    disease of anatomical entity 14327
      nervous system disease 12611
        central nervous system disease 11273
          brain disease 10581
            movement disease 2426
              Dyskinesias 2070
                Drug-Induced Dyskinesia 33
                  Tardive Dyskinesia 3
paths to the root