RGD DISEASE ONTOLOGY - ANNOTATIONS
RGD uses the Human Disease Ontology (DO, https://disease-ontology.org/) for disease curation across species. RGD automatically downloads each new release of the ontology on a monthly basis. Some additional terms which are required for RGD's curation purposes but are not currently covered in the official version of DO have been added. As corresponding terms are added to DO, these custom terms are retired and the DO terms substituted in existing annotations and subsequently used for curation.
Term: Drug-Induced Dyskinesia
Accession: DOID:9008394
browse the term
Definition: Abnormal movements, including HYPERKINESIS; HYPOKINESIA; TREMOR; and DYSTONIA, associated with the use of certain medications or drugs. Muscles of the face, trunk, neck, and extremities are most commonly affected. Tardive dyskinesia refers to abnormal hyperkinetic movements of the muscles of the face, tongue, and neck associated with the use of neuroleptic agents (see ANTIPSYCHOTIC AGENTS). (Adams et al., Principles of Neurology, 6th ed, p1199)
Synonyms: exact_synonym: Drug-Induced Dyskinesias; Medication Induced Dyskinesia; Medication-Induced Dyskinesias
primary_id: MESH:D004409
xref: EFO:1000904
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Abat
4-aminobutyrate aminotransferase
ISO
RGD
PMID:6445277 PMID:7740056
RGD:10047091 RGD:1598524
NCBI chrNW_004936530:7,543,743...7,621,392
Ensembl chrNW_004936530:7,543,682...7,622,667
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Cacna1d
calcium voltage-gated channel subunit alpha1 D
ISO
RGD
PMID:18947822
RGD:6906919
NCBI chrNW_004936473:4,164,633...4,479,866
Ensembl chrNW_004936473:4,037,533...4,478,073
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Cat
catalase
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:19109989
NCBI chrNW_004936533:3,601,270...3,637,128
Ensembl chrNW_004936533:3,600,955...3,637,422
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Cck
cholecystokinin
ISO
CTD Direct Evidence: therapeutic
CTD
PMID:2320253
NCBI chrNW_004936695:2,776,705...2,782,280
Ensembl chrNW_004936695:2,776,831...2,782,061
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Comt
catechol-O-methyltransferase
ISO
RGD
PMID:16437585
RGD:2289781
NCBI chrNW_004936619:3,847,059...3,883,866
Ensembl chrNW_004936619:3,876,299...3,882,747
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Dbn1
drebrin 1
ISO
levodopainduced; protein:increased expression:striatum:
RGD
PMID:23241013
RGD:10398811
NCBI chrNW_004936597:1,735,589...1,751,628
Ensembl chrNW_004936597:1,735,380...1,747,569
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Ddc
dopa decarboxylase
ISO
associated with Parkinson Disease; protein:decreased expression:striatum (rat)
RGD
PMID:20232137
RGD:5128860
NCBI chrNW_004936686:1,322,153...1,405,434
Ensembl chrNW_004936686:1,301,207...1,405,384
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Drd1
dopamine receptor D1
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:7845605 PMID:10858612 PMID:16982285 PMID:19520364
NCBI chrNW_004936609:790,647...795,187
Ensembl chrNW_004936609:792,276...793,613
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Drd2
dopamine receptor D2
ISO
CTD Direct Evidence: marker/mechanism
CTD RGD
PMID:7845605 PMID:10534246 PMID:14629710 PMID:18707801
RGD:2311579
NCBI chrNW_004936612:1,094,686...1,154,149
Ensembl chrNW_004936612:1,094,680...1,154,798
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Drd3
dopamine receptor D3
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:20945430
NCBI chrNW_004936536:1,580,732...1,616,726
Ensembl chrNW_004936536:1,580,732...1,616,725
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Egr1
early growth response 1
ISO
RGD
PMID:22153973
RGD:10395307
NCBI chrNW_004936531:7,625,956...7,629,041
Ensembl chrNW_004936531:7,625,892...7,629,749
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Fosb
FosB proto-oncogene, AP-1 transcription factor subunit
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:17219962
NCBI chrNW_004936706:1,900,954...1,907,567
Ensembl chrNW_004936706:1,900,931...1,906,772
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Gad1
glutamate decarboxylase 1
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:9767399
NCBI chrNW_004936509:1,160,559...1,201,037
Ensembl chrNW_004936509:1,161,094...1,201,576
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Gch1
GTP cyclohydrolase 1
ISO
CTD Direct Evidence: therapeutic
CTD
PMID:15659429
NCBI chrNW_004936697:232,048...275,420
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Gdnf
glial cell derived neurotrophic factor
ISO
CTD Direct Evidence: therapeutic
CTD
PMID:11168568
NCBI chrNW_004936518:4,291,391...4,310,752
Ensembl chrNW_004936518:4,288,154...4,310,753
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Glul
glutamate-ammonia ligase
ISO
RGD
PMID:6445277
RGD:10047091
NCBI chrNW_004936481:7,293,301...7,301,416
Ensembl chrNW_004936481:7,293,091...7,306,202
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Grk6
G protein-coupled receptor kinase 6
ISO
associated with Parkinson Disease
RGD
PMID:20410529
RGD:5684919
NCBI chrNW_004936597:1,706,671...1,722,370
Ensembl chrNW_004936597:1,706,665...1,722,370
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Gsk3b
glycogen synthase kinase 3 beta
treatment
ISO
associated with Parkinsonian Disorders
RGD
PMID:26997328
RGD:13792768
NCBI chrNW_004936536:6,730,070...6,893,818
Ensembl chrNW_004936536:6,730,062...6,894,303
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Homer1
homer scaffold protein 1
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:24126708
NCBI chrNW_004936549:7,189,588...7,320,117
Ensembl chrNW_004936549:7,188,850...7,320,312
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Htr1a
5-hydroxytryptamine receptor 1A
ISO
RGD
PMID:21352823
RGD:5683628
NCBI chrNW_004936480:5,042,531...5,047,157
Ensembl chrNW_004936480:5,043,204...5,044,472
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LOC101961588
cytochrome P450 2D17
ISO
RGD
PMID:12629505
RGD:1358549
NCBI chrNW_004936718:153,340...157,966
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Mapt
microtubule associated protein tau
treatment
ISO
associated with Parkinsonian Disorders
RGD
PMID:25511986
RGD:13800920
NCBI chrNW_004936541:2,381,411...2,479,984
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Mtor
mechanistic target of rapamycin kinase
treatment
ISO
associated with Parkinsonian Disorders
RGD
PMID:23938307
RGD:10040953
NCBI chrNW_004936474:158,376...282,310
Ensembl chrNW_004936474:157,590...282,342
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Pdyn
prodynorphin
treatment severity
ISO
CTD Direct Evidence: marker/mechanism associated with Parkinsonism associated with Parkinsonism;protein:increased expression:striatum
CTD RGD
PMID:9767399 PMID:10869049 PMID:17884291 PMID:21737418
RGD:401850563 RGD:401851046 RGD:401900134
NCBI chrNW_004936485:16,559,371...16,571,461
Ensembl chrNW_004936485:16,559,217...16,571,678
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Penk
proenkephalin
treatment disease_progression
ISO
mRNA:increased expression:brain:striatum: CTD Direct Evidence: marker/mechanism associated with Parkinsonism associated with Parkinsonism;mRNA:increased expression:striatum
RGD CTD
PMID:9767399 PMID:10869049 PMID:20456008 PMID:26113400
RGD:10003039 RGD:401851054 RGD:401900134
NCBI chrNW_004936496:3,016,247...3,021,726
Ensembl chrNW_004936496:3,016,218...3,021,738
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Ppp1r1b
protein phosphatase 1 regulatory inhibitor subunit 1B
treatment
ISO
associated with Parkinsonian Disorders
RGD
PMID:27771532
RGD:13514053
NCBI chrNW_004936490:14,822,246...14,831,337
Ensembl chrNW_004936490:14,822,213...14,831,349
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Rasgrf1
Ras protein specific guanine nucleotide releasing factor 1
ISO
CTD Direct Evidence: therapeutic
CTD
PMID:21115823
NCBI chrNW_004936471:37,173,595...37,278,356
Ensembl chrNW_004936471:37,171,297...37,278,529
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Rela
RELA proto-oncogene, NF-kB subunit
ISO
protein:increased expression:nucleus, brain
RGD
PMID:18590723
RGD:2298778
NCBI chrNW_004936599:3,800,142...3,810,583
Ensembl chrNW_004936599:3,801,636...3,809,813
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Rgs4
regulator of G protein signaling 4
treatment
ISO
associated with Parkinsonian Disorders
RGD
PMID:24969021
RGD:13524515
NCBI chrNW_004937238:101,948...109,513
Ensembl chrNW_004937238:102,061...109,474
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Rgs9
regulator of G protein signaling 9
ISO
CTD Direct Evidence: marker/mechanism|therapeutic
CTD
PMID:18160641 PMID:24663062
NCBI chrNW_004936541:7,472,195...7,525,220
Ensembl chrNW_004936541:7,458,539...7,525,220
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Th
tyrosine hydroxylase
ISO
CTD Direct Evidence: therapeutic
CTD
PMID:15659429
NCBI chrNW_004936794:478,651...486,887
Ensembl chrNW_004936794:478,614...487,061
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Drd3
dopamine receptor D3
ISO
associated with schizophrenia
RGD
PMID:12960753
RGD:1581250
NCBI chrNW_004936536:1,580,732...1,616,726
Ensembl chrNW_004936536:1,580,732...1,616,725
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LOC101969421
cytochrome P450 1A2
treatment
ISO
associated with schizophrenia
RGD
PMID:10889552
RGD:1358545
NCBI chrNW_004936471:33,704,616...33,709,455
Ensembl chrNW_004936471:33,703,792...33,709,484
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Sod2
superoxide dismutase 2
ISO
associated with schizophrenia
RGD
PMID:12960753
RGD:1581250
NCBI chrNW_004936489:11,178,338...11,191,601
Ensembl chrNW_004936489:11,178,015...11,191,781
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