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RGD DISEASE ONTOLOGY - ANNOTATIONS

RGD uses the Human Disease Ontology (DO, https://disease-ontology.org/) for disease curation across species. RGD automatically downloads each new release of the ontology on a monthly basis. Some additional terms which are required for RGD's curation purposes but are not currently covered in the official version of DO have been added. As corresponding terms are added to DO, these custom terms are retired and the DO terms substituted in existing annotations and subsequently used for curation.

Term:Drug-Induced Dyskinesia
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Accession:DOID:9008394 term browser browse the term
Definition:Abnormal movements, including HYPERKINESIS; HYPOKINESIA; TREMOR; and DYSTONIA, associated with the use of certain medications or drugs. Muscles of the face, trunk, neck, and extremities are most commonly affected. Tardive dyskinesia refers to abnormal hyperkinetic movements of the muscles of the face, tongue, and neck associated with the use of neuroleptic agents (see ANTIPSYCHOTIC AGENTS). (Adams et al., Principles of Neurology, 6th ed, p1199)
Synonyms:exact_synonym: Drug-Induced Dyskinesias;   Medication Induced Dyskinesia;   Medication-Induced Dyskinesias
 primary_id: MESH:D004409
 xref: EFO:1000904



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Drug-Induced Dyskinesia term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ABAT 4-aminobutyrate aminotransferase ISO RGD PMID:6445277 PMID:7740056 RGD:10047091 RGD:1598524 NCBI chr 3:33,913,068...33,960,804
Ensembl chr 3:33,908,970...34,015,474
JBrowse link
G CACNA1D calcium voltage-gated channel subunit alpha1 D ISO RGD PMID:18947822 RGD:6906919 NCBI chr13:35,568,534...35,911,483
Ensembl chr13:35,436,519...35,909,662
JBrowse link
G CAT catalase ISO CTD Direct Evidence: marker/mechanism CTD PMID:19109989 NCBI chr 2:26,493,664...26,533,881
Ensembl chr 2:26,487,653...26,581,452
JBrowse link
G CCK cholecystokinin ISO CTD Direct Evidence: therapeutic CTD PMID:2320253 NCBI chr13:25,940,674...25,945,879
Ensembl chr13:25,937,645...25,945,793
JBrowse link
G COMT catechol-O-methyltransferase ISO RGD PMID:16437585 RGD:2289781 NCBI chr14:51,384,729...51,403,997
Ensembl chr14:51,385,738...51,403,998
JBrowse link
G CYP2D6 cytochrome P450 family 2 subfamily D member 6 ISO RGD PMID:12629505 RGD:1358549 NCBI chr 5:6,539,021...6,543,643
Ensembl chr 5:6,538,907...6,543,642
JBrowse link
G DBN1 drebrin 1 ISO levodopainduced; protein:increased expression:striatum: RGD PMID:23241013 RGD:10398811 NCBI chr 2:80,480,603...80,495,797
Ensembl chr 2:80,479,460...80,495,796
JBrowse link
G DDC dopa decarboxylase ISO associated with Parkinson Disease; protein:decreased expression:striatum (rat) RGD PMID:20232137 RGD:5128860 NCBI chr 9:136,496,364...136,571,220
Ensembl chr 9:136,496,365...136,571,212
JBrowse link
G DRD1 dopamine receptor D1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:7845605 PMID:10858612 PMID:16982285 PMID:19520364 NCBI chr16:49,189,555...49,193,722
Ensembl chr16:49,189,602...49,191,976
JBrowse link
G DRD2 dopamine receptor D2 ISO CTD Direct Evidence: marker/mechanism RGD
CTD
PMID:7845605 PMID:10534246 PMID:14629710 PMID:18707801 RGD:2311579 NCBI chr 9:41,068,618...41,135,262
Ensembl chr 9:41,068,779...41,133,599
JBrowse link
G DRD3 dopamine receptor D3 ISO CTD Direct Evidence: marker/mechanism CTD PMID:20945430 NCBI chr13:145,769,294...145,817,997
Ensembl chr13:145,771,774...145,819,168
JBrowse link
G EGR1 early growth response 1 ISO RGD PMID:22153973 RGD:10395307 NCBI chr 2:140,440,829...140,445,302
Ensembl chr 2:140,441,421...140,445,296
JBrowse link
G FOSB FosB proto-oncogene, AP-1 transcription factor subunit ISO CTD Direct Evidence: marker/mechanism CTD PMID:17219962 NCBI chr 6:51,836,780...51,844,531
Ensembl chr 6:51,837,719...51,844,529
JBrowse link
G GAD1 glutamate decarboxylase 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:9767399 NCBI chr15:76,991,863...77,034,819
Ensembl chr15:76,991,928...77,034,812
JBrowse link
G GCH1 GTP cyclohydrolase 1 ISO CTD Direct Evidence: therapeutic CTD PMID:15659429 NCBI chr 1:184,201,232...184,264,060
Ensembl chr 1:184,199,679...184,257,315
JBrowse link
G GDNF glial cell derived neurotrophic factor ISO CTD Direct Evidence: therapeutic CTD PMID:11168568 NCBI chr16:22,936,602...22,965,929
Ensembl chr16:22,936,604...22,966,536
JBrowse link
G GLUL glutamate-ammonia ligase ISO RGD PMID:6445277 RGD:10047091 NCBI chr 9:123,751,551...123,762,575
Ensembl chr 9:123,748,380...123,762,545
JBrowse link
G GRK6 G protein-coupled receptor kinase 6 ISO associated with Parkinson Disease RGD PMID:20410529 RGD:5684919 NCBI chr 2:80,496,105...80,527,208
Ensembl chr 2:80,508,979...80,527,210
JBrowse link
G GSK3B glycogen synthase kinase 3 beta treatment ISO associated with Parkinsonian Disorders RGD PMID:26997328 RGD:13792768 NCBI chr13:140,136,109...140,370,197
Ensembl chr13:140,136,158...140,369,569
JBrowse link
G HOMER1 homer scaffold protein 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:24126708 NCBI chr 2:88,116,664...88,253,843
Ensembl chr 2:88,122,882...88,255,281
JBrowse link
G HTR1A 5-hydroxytryptamine receptor 1A ISO RGD PMID:21352823 RGD:5683628 NCBI chr16:42,479,812...42,484,365
Ensembl chr16:42,478,923...42,484,304
JBrowse link
G MAPT microtubule associated protein tau treatment ISO associated with Parkinsonian Disorders RGD PMID:25511986 RGD:13800920 NCBI chr12:17,098,259...17,211,483
Ensembl chr12:17,095,587...17,211,373
JBrowse link
G MTOR mechanistic target of rapamycin kinase treatment ISO associated with Parkinsonian Disorders RGD PMID:23938307 RGD:10040953 NCBI chr 6:71,286,989...71,412,913
Ensembl chr 6:71,286,989...71,412,888
JBrowse link
G PDYN prodynorphin severity
treatment
ISO CTD Direct Evidence: marker/mechanism
associated with Parkinsonism;protein:increased expression:striatum
CTD
RGD
PMID:9767399 PMID:10869049 PMID:17884291 PMID:21737418 RGD:401850563 RGD:401851046 RGD:401900134 NCBI chr17:33,505,075...33,521,534
Ensembl chr17:33,505,079...33,521,532
JBrowse link
G PENK proenkephalin disease_progression
treatment
ISO mRNA:increased expression:brain:striatum:
CTD Direct Evidence: marker/mechanism
associated with Parkinsonism;mRNA:increased expression:striatum
RGD
CTD
PMID:9767399 PMID:10869049 PMID:20456008 PMID:26113400 RGD:10003039 RGD:401851054 RGD:401900134 NCBI chr 4:75,525,497...75,530,403
Ensembl chr 4:75,525,555...75,530,876
JBrowse link
G PPP1R1B protein phosphatase 1 regulatory inhibitor subunit 1B treatment ISO associated with Parkinsonian Disorders RGD PMID:27771532 RGD:13514053 NCBI chr12:22,681,244...22,690,978
Ensembl chr12:22,680,980...22,690,952
JBrowse link
G RASGRF1 Ras protein specific guanine nucleotide releasing factor 1 ISO CTD Direct Evidence: therapeutic CTD PMID:21115823 NCBI chr 7:48,121,415...48,246,749
Ensembl chr 7:48,121,419...48,246,749
JBrowse link
G RELA RELA proto-oncogene, NF-kB subunit ISO protein:increased expression:nucleus, brain RGD PMID:18590723 RGD:2298778 NCBI chr 2:6,594,869...6,602,684
Ensembl chr 2:6,593,969...6,603,469
JBrowse link
G RGS4 regulator of G protein signaling 4 treatment ISO associated with Parkinsonian Disorders RGD PMID:24969021 RGD:13524515 NCBI chr 4:87,383,336...87,390,478
Ensembl chr 4:87,383,345...87,390,893
JBrowse link
G RGS9 regulator of G protein signaling 9 ISO CTD Direct Evidence: marker/mechanism|therapeutic CTD PMID:18160641 PMID:24663062 NCBI chr12:12,015,321...12,087,982
Ensembl chr12:12,015,321...12,087,976
JBrowse link
G TH tyrosine hydroxylase ISO CTD Direct Evidence: therapeutic CTD PMID:15659429 NCBI chr 2:1,499,628...1,506,180
Ensembl chr 2:1,499,620...1,506,170
JBrowse link
Tardive Dyskinesia term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G CYP1A2 cytochrome P450 family 1 subfamily A member 2 treatment ISO associated with schizophrenia RGD PMID:10889552 RGD:1358545 NCBI chr 7:58,779,529...58,786,155
Ensembl chr 7:58,779,475...58,786,100
JBrowse link
G DRD3 dopamine receptor D3 ISO associated with schizophrenia RGD PMID:12960753 RGD:1581250 NCBI chr13:145,769,294...145,817,997
Ensembl chr13:145,771,774...145,819,168
JBrowse link
G SOD2 superoxide dismutase 2 ISO associated with schizophrenia RGD PMID:12960753 RGD:1581250 NCBI chr 1:7,679,352...7,689,564
Ensembl chr 1:7,679,352...7,689,560
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  disease 15430
    syndrome 10412
      toxic encephalopathy 204
        Drug-Induced Dyskinesia 33
          Tardive Dyskinesia 3
Path 2
Term Annotations click to browse term
  disease 15430
    disease of anatomical entity 15099
      nervous system disease 13251
        central nervous system disease 11841
          brain disease 11114
            movement disease 2509
              Dyskinesias 2137
                Drug-Induced Dyskinesia 33
                  Tardive Dyskinesia 3
paths to the root