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RGD DISEASE ONTOLOGY - ANNOTATIONS

RGD uses the Human Disease Ontology (DO, https://disease-ontology.org/) for disease curation across species. RGD automatically downloads each new release of the ontology on a monthly basis. Some additional terms which are required for RGD's curation purposes but are not currently covered in the official version of DO have been added. As corresponding terms are added to DO, these custom terms are retired and the DO terms substituted in existing annotations and subsequently used for curation.

Term:Drug-Induced Dyskinesia
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Accession:DOID:9008394 term browser browse the term
Definition:Abnormal movements, including HYPERKINESIS; HYPOKINESIA; TREMOR; and DYSTONIA, associated with the use of certain medications or drugs. Muscles of the face, trunk, neck, and extremities are most commonly affected. Tardive dyskinesia refers to abnormal hyperkinetic movements of the muscles of the face, tongue, and neck associated with the use of neuroleptic agents (see ANTIPSYCHOTIC AGENTS). (Adams et al., Principles of Neurology, 6th ed, p1199)
Synonyms:exact_synonym: Drug-Induced Dyskinesias;   Medication Induced Dyskinesia;   Medication-Induced Dyskinesias
 primary_id: MESH:D004409
 xref: EFO:1000904


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Drug-Induced Dyskinesia term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abat 4-aminobutyrate aminotransferase ISO RGD PMID:6445277 PMID:7740056 RGD:10047091 RGD:1598524 NCBI chrNW_004624824:6,112,644...6,202,936
Ensembl chrNW_004624824:6,141,213...6,202,936
JBrowse link
G Cacna1d calcium voltage-gated channel subunit alpha1 D ISO RGD PMID:18947822 RGD:6906919 NCBI chrNW_004624822:3,391,045...3,734,258
Ensembl chrNW_004624822:3,392,044...3,919,415
JBrowse link
G Cat catalase ISO CTD Direct Evidence: marker/mechanism CTD PMID:19109989 NCBI chrNW_004624767:12,680,940...12,715,468
Ensembl chrNW_004624767:12,680,953...12,715,739
JBrowse link
G Cck cholecystokinin ISO CTD Direct Evidence: therapeutic CTD PMID:2320253 NCBI chrNW_004624730:77,310,080...77,314,258
Ensembl chrNW_004624730:77,309,633...77,314,384
JBrowse link
G Comt catechol-O-methyltransferase ISO RGD PMID:16437585 RGD:2289781 NCBI chrNW_004624747:569,127...588,479
Ensembl chrNW_004624747:581,832...588,333
JBrowse link
G Dbn1 drebrin 1 ISO levodopainduced; protein:increased expression:striatum: RGD PMID:23241013 RGD:10398811 NCBI chrNW_004624733:12,616,537...12,631,967
Ensembl chrNW_004624733:12,616,423...12,632,133
JBrowse link
G Ddc dopa decarboxylase ISO associated with Parkinson Disease; protein:decreased expression:striatum (rat) RGD PMID:20232137 RGD:5128860 NCBI chrNW_004624740:3,674,727...3,732,058
Ensembl chrNW_004624740:3,674,609...3,732,676
JBrowse link
G Drd1 dopamine receptor D1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:7845605 PMID:10858612 PMID:16982285 PMID:19520364 NCBI chrNW_004624733:14,517,540...14,522,173
Ensembl chrNW_004624733:14,518,146...14,520,905
JBrowse link
G Drd2 dopamine receptor D2 ISO CTD Direct Evidence: marker/mechanism CTD
RGD
PMID:7845605 PMID:10534246 PMID:14629710 PMID:18707801 RGD:2311579 NCBI chrNW_004624784:8,828,589...8,906,617
Ensembl chrNW_004624784:8,827,006...8,865,529
JBrowse link
G Drd3 dopamine receptor D3 ISO CTD Direct Evidence: marker/mechanism CTD PMID:20945430 NCBI chrNW_004624731:34,318,733...34,369,111
Ensembl chrNW_004624731:34,319,130...34,363,184
JBrowse link
G Egr1 early growth response 1 ISO RGD PMID:22153973 RGD:10395307 NCBI chrNW_004624743:31,247,855...31,251,675
Ensembl chrNW_004624743:31,247,516...31,252,205
JBrowse link
G Fosb FosB proto-oncogene, AP-1 transcription factor subunit ISO CTD Direct Evidence: marker/mechanism CTD PMID:17219962 NCBI chrNW_004624907:2,332,746...2,338,825
Ensembl chrNW_004624907:2,328,691...2,339,099
JBrowse link
G Gad1 glutamate decarboxylase 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:9767399 NCBI chrNW_004624787:8,308,759...8,345,929
Ensembl chrNW_004624787:8,308,759...8,347,686
JBrowse link
G Gch1 GTP cyclohydrolase 1 ISO CTD Direct Evidence: therapeutic CTD PMID:15659429 NCBI chrNW_004624731:14,459,164...14,502,485
Ensembl chrNW_004624731:14,459,303...14,500,429
JBrowse link
G Gdnf glial cell derived neurotrophic factor ISO CTD Direct Evidence: therapeutic CTD PMID:11168568 NCBI chrNW_004624759:17,263,570...17,290,046
Ensembl chrNW_004624759:17,263,969...17,287,723
JBrowse link
G Glul glutamate-ammonia ligase ISO RGD PMID:6445277 RGD:10047091 NCBI chrNW_004624771:2,608,779...2,618,130 JBrowse link
G Grk6 G protein-coupled receptor kinase 6 ISO associated with Parkinson Disease RGD PMID:20410529 RGD:5684919 NCBI chrNW_004624733:12,633,565...12,661,284 JBrowse link
G Gsk3b glycogen synthase kinase 3 beta treatment ISO associated with Parkinsonian Disorders RGD PMID:26997328 RGD:13792768 NCBI chrNW_004624731:28,178,647...28,368,784
Ensembl chrNW_004624731:28,178,628...28,366,420
JBrowse link
G Homer1 homer scaffold protein 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:24126708 NCBI chrNW_004624869:3,878,646...4,012,211
Ensembl chrNW_004624869:3,880,001...4,012,240
JBrowse link
G Htr1a 5-hydroxytryptamine receptor 1A ISO RGD PMID:21352823 RGD:5683628 NCBI chrNW_004624815:5,817,196...5,821,197
Ensembl chrNW_004624815:5,816,601...5,820,864
JBrowse link
G Mapt microtubule associated protein tau treatment ISO associated with Parkinsonian Disorders RGD PMID:25511986 RGD:13800920 NCBI chrNW_004624849:2,320,887...2,421,099 JBrowse link
G Mtor mechanistic target of rapamycin kinase treatment ISO associated with Parkinsonian Disorders RGD PMID:23938307 RGD:10040953 NCBI chrNW_004624818:1,570,155...1,698,264
Ensembl chrNW_004624818:1,570,276...1,698,259
JBrowse link
G Pdyn prodynorphin treatment
severity
ISO CTD Direct Evidence: marker/mechanism
associated with Parkinsonism
associated with Parkinsonism;protein:increased expression:striatum
CTD
RGD
PMID:9767399 PMID:10869049 PMID:17884291 PMID:21737418 RGD:401850563 RGD:401851046 RGD:401900134 NCBI chrNW_004624741:3,239,101...3,253,507
Ensembl chrNW_004624741:3,237,942...3,253,503
JBrowse link
G Penk proenkephalin disease_progression
treatment
ISO mRNA:increased expression:brain:striatum:
CTD Direct Evidence: marker/mechanism
associated with Parkinsonism;mRNA:increased expression:striatum
RGD
CTD
PMID:9767399 PMID:10869049 PMID:20456008 PMID:26113400 RGD:10003039 RGD:401851054 RGD:401900134 NCBI chrNW_004624886:3,595,485...3,613,117
Ensembl chrNW_004624886:3,595,450...3,613,593
JBrowse link
G Ppp1r1b protein phosphatase 1 regulatory inhibitor subunit 1B treatment ISO associated with Parkinsonian Disorders RGD PMID:27771532 RGD:13514053 NCBI chrNW_004624795:3,432,179...3,439,490
Ensembl chrNW_004624795:3,431,689...3,439,545
JBrowse link
G Rasgrf1 Ras protein specific guanine nucleotide releasing factor 1 ISO CTD Direct Evidence: therapeutic CTD PMID:21115823 NCBI chrNW_004624941:110,752...222,143
Ensembl chrNW_004624941:110,676...222,092
JBrowse link
G Rela RELA proto-oncogene, NF-kB subunit ISO protein:increased expression:nucleus, brain RGD PMID:18590723 RGD:2298778 NCBI chrNW_004624767:20,732,813...20,742,016
Ensembl chrNW_004624767:20,732,938...20,741,272
JBrowse link
G Rgs4 regulator of G protein signaling 4 treatment ISO associated with Parkinsonian Disorders RGD PMID:24969021 RGD:13524515 NCBI chrNW_004624826:1,570,143...1,577,300
Ensembl chrNW_004624826:1,569,854...1,579,627
JBrowse link
G Rgs9 regulator of G protein signaling 9 ISO CTD Direct Evidence: marker/mechanism|therapeutic CTD PMID:18160641 PMID:24663062 NCBI chrNW_004624870:3,138,311...3,249,297
Ensembl chrNW_004624870:3,143,950...3,218,117
JBrowse link
G Th tyrosine hydroxylase ISO CTD Direct Evidence: therapeutic CTD PMID:15659429 NCBI chrNW_004624767:15,003,073...15,010,207
Ensembl chrNW_004624767:15,003,092...15,010,154
JBrowse link
Tardive Dyskinesia term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Drd3 dopamine receptor D3 ISO associated with schizophrenia RGD PMID:12960753 RGD:1581250 NCBI chrNW_004624731:34,318,733...34,369,111
Ensembl chrNW_004624731:34,319,130...34,363,184
JBrowse link
G Sod2 superoxide dismutase 2 ISO associated with schizophrenia RGD PMID:12960753 RGD:1581250 NCBI chrNW_004624855:3,260,800...3,271,864
Ensembl chrNW_004624855:3,260,809...3,271,367
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  disease 14230
    syndrome 9722
      toxic encephalopathy 185
        Drug-Induced Dyskinesia 31
          Tardive Dyskinesia 2
Path 2
Term Annotations click to browse term
  disease 14230
    disease of anatomical entity 13932
      nervous system disease 12270
        central nervous system disease 10995
          brain disease 10311
            movement disease 2382
              Dyskinesias 2035
                Drug-Induced Dyskinesia 31
                  Tardive Dyskinesia 2
paths to the root